Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	EGF_LAM_2	USH2A AGRN	1.69e-03	30	38	2	PS50027
Domain	EGF_LAM_1	USH2A AGRN	1.69e-03	30	38	2	PS01248
Domain	Laminin_EGF	USH2A AGRN	2.30e-03	35	38	2	PF00053
Domain	EGF_Lam	USH2A AGRN	2.30e-03	35	38	2	SM00180
Domain	LAM_G_DOMAIN	USH2A AGRN	2.71e-03	38	38	2	PS50025
Domain	Laminin_EGF	USH2A AGRN	2.71e-03	38	38	2	IPR002049
Domain	LamG	USH2A AGRN	3.61e-03	44	38	2	SM00282
Domain	fn3	CHL1 IGF1R USH2A	4.33e-03	162	38	3	PF00041
Domain	Laminin_G	USH2A AGRN	6.20e-03	58	38	2	IPR001791
Domain	FN3	CHL1 IGF1R USH2A	6.25e-03	185	38	3	SM00060
Domain	Ig_I-set	CHL1 KDR ADAMTSL1	6.73e-03	190	38	3	IPR013098
Domain	I-set	CHL1 KDR ADAMTSL1	6.73e-03	190	38	3	PF07679
Domain	FN3	CHL1 IGF1R USH2A	7.64e-03	199	38	3	PS50853
Pathway	REACTOME_SHC_RELATED_EVENTS_TRIGGERED_BY_IGF1R	GRB2 IGF1R	6.98e-05	6	31	2	MM14887
Pathway	WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING	GRB2 PARP1 KDR IGF1R	8.74e-05	108	31	4	M48078
Pubmed	A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis.	KDR AGRN	1.36e-06	2	41	2	31340156
Pubmed	Insulin-like growth factor receptor I (IGF-IR) and vascular endothelial growth factor receptor 2 (VEGFR-2) are expressed on the circulating epithelial tumor cells of breast cancer patients.	KDR IGF1R	1.36e-06	2	41	2	23418605
Pubmed	PARP1 modulates METTL3 promoter chromatin accessibility and associated LPAR5 RNA m6A methylation to control cancer cell radiosensitivity.	PARP1 METTL3	1.36e-06	2	41	2	37482682
Pubmed	Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.	PARP1 WWP2	1.36e-06	2	41	2	32139900
Pubmed	The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia.	PARP1 WWP2	1.36e-06	2	41	2	36257929
Pubmed	Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between αVβ3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesis.	KDR IGF1R	4.06e-06	3	41	2	23331867
Pubmed	Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.	PARP1 WWP2	4.06e-06	3	41	2	31924572
Pubmed	Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells.	GRB2 IGF1R	4.06e-06	3	41	2	9553137
Pubmed	FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.	METTL3 FBXO31	4.06e-06	3	41	2	38216561
Pubmed	IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.	GRB2 IGF1R	8.12e-06	4	41	2	12483226
Pubmed	Poly(ADP-ribose) polymerase as a novel regulator of 17β-estradiol-induced cell growth through a control of the estrogen receptor/IGF-1 receptor/PDZK1 axis.	PARP1 IGF1R	8.12e-06	4	41	2	26183824
Pubmed	c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1.	GRB2 KDR	8.12e-06	4	41	2	22327338
Pubmed	Acute stretch promotes endothelial cell proliferation in wounded healing mouse skin.	KDR IGF1R	8.12e-06	4	41	2	18330587
Pubmed	Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.	GRB2 IGF1R	8.12e-06	4	41	2	9852124
Pubmed	BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.	PARP1 IGF1R	8.12e-06	4	41	2	19996272
Pubmed	16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells.	GRB2 KDR	1.35e-05	5	41	2	10319320
Pubmed	Vascular endothelial growth factor is important for brown adipose tissue development and maintenance.	KDR COX4I1	1.35e-05	5	41	2	23682123
Pubmed	A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.	PARP1 COX4I1	2.03e-05	6	41	2	15565177
Pubmed	Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.	GRB2 KDR	2.84e-05	7	41	2	16966330
Pubmed	Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.	GRB2 KDR	4.86e-05	9	41	2	25187647
Pubmed	Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.	GRB2 IGF1R	4.86e-05	9	41	2	11094073
Pubmed	Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.	GRB2 GSTK1 C21orf58 PIK3R5	5.92e-05	179	41	4	18624398
Pubmed	Macrophage-derived IGF-1 protects the neonatal intestine against necrotizing enterocolitis by promoting microvascular development.	KDR IGF1R	6.07e-05	10	41	2	35388142
Pubmed	Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes.	GRB2 IGF1R	6.07e-05	10	41	2	33567274
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	GRB2 PARP1 IGF1R GSTK1 WFS1 SF3B2 WWP2 DHX8	8.89e-05	1247	41	8	27684187
Pubmed	HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes.	KDR COX4I1	1.05e-04	13	41	2	26028220
Pubmed	Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development.	PARP1 KDR	1.22e-04	14	41	2	22275127
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	PARP1 AGRN TNPO2 WWP2	1.29e-04	219	41	4	31353912
Pubmed	Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse.	KDR IGF1R	1.41e-04	15	41	2	14502571
Pubmed	Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.	KDR IGF1R	1.61e-04	16	41	2	11897712
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	LIAS DNAH3 SLFN5 TNPO2 NDUFS2 VPS13A	2.11e-04	736	41	6	29676528
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	HOXA5 GPD2 GRB2 PARP1 DENND1A COX4I1 TNPO2 NDUFS2	2.39e-04	1440	41	8	30833792
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	GPD2 PARP1 AGRN PIK3R5 NDUFS2 SF3B2 DHX8	2.47e-04	1082	41	7	38697112
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	GRB2 PARP1 WFS1 COX4I1 NDUFS2 SF3B2 WWP2 VPS13A	2.97e-04	1487	41	8	33957083
Pubmed	The imprinted Phlda2 gene regulates extraembryonic energy stores.	KDR IGF1R	3.09e-04	22	41	2	19884348
Pubmed	HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy.	PARP1 IGF1R	3.09e-04	22	41	2	15103018
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	HOXA5 GRB2 COX4I1 TNPO2 WWP2	3.94e-04	533	41	5	25544563
Pubmed	Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.	KDR IGF1R	4.00e-04	25	41	2	15254900
Pubmed	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	GPD2 LIAS GSTK1 COX4I1 NDUFS2	4.26e-04	542	41	5	14651853
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	PARP1 SLFN5 DHX8	4.79e-04	129	41	3	23022380
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	KDR IGF1R	5.03e-04	28	41	2	18593464
Pubmed	WFS1 Spectrum Disorder	GPD2 WFS1	5.03e-04	28	41	2	20301750
Pubmed	Integrating genetic and network analysis to characterize genes related to mouse weight.	GPD2 TDO2	5.39e-04	29	41	2	16934000
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	PARP1 SF3B2	5.78e-04	30	41	2	17403666
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	GRB2 SF3B2	6.17e-04	31	41	2	22323290
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	GSTK1 WFS1 COX4I1 NDUFS2	6.18e-04	331	41	4	29199018
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	GPD2 GSTK1 COX4I1 NDUFS2	7.06e-04	343	41	4	28130547
Pubmed	Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets.	CHL1 HOXA5	7.43e-04	34	41	2	32553152
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	GPD2 METTL3 IGF1R WFS1 NDUFS2	7.87e-04	621	41	5	22794259
Pubmed	Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.	KDR COX4I1	9.28e-04	38	41	2	22783020
Pubmed	DNA sequence and analysis of human chromosome 9.	TRPM6 ADAMTSL1 DENND1A VPS13A	9.35e-04	370	41	4	15164053
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	GRB2 IGF1R	1.03e-03	40	41	2	30898150
Pubmed	High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.	HOXA5 KDR IGF1R PIK3R5	1.06e-03	383	41	4	19453261
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	CHL1 PARP1 IGF1R	1.07e-03	170	41	3	19064572
Pubmed	Proteomic analysis of the mouse liver mitochondrial inner membrane.	GPD2 GSTK1 COX4I1	1.16e-03	175	41	3	12865426
Interaction	ATP5F1A interactions	GRB2 PARP1 KDR METTL3 IGF1R GSTK1 COX4I1 NDUFS2 WWP2	3.52e-06	640	40	9	int:ATP5F1A
Interaction	TTYH2 interactions	GRB2 IGF1R AGRN	1.25e-05	23	40	3	int:TTYH2
Interaction	GRB2 interactions	EFHC2 GRB2 PARP1 KDR IGF1R GSTK1 C21orf58 SF3B2 WWP2	2.24e-05	806	40	9	int:GRB2
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	KDR IGF1R	1.74e-03	40	28	2	321
GeneFamily	Fibronectin type III domain containing	CHL1 IGF1R USH2A	1.89e-03	160	28	3	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	CHL1 KDR ADAMTSL1	1.93e-03	161	28	3	593
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	GPD2 GRB2 FIG4 DENND1A PIK3R5	9.59e-07	195	41	5	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C2orf80 ADAMTSL1 GSTK1 FBXO31	1.91e-05	173	41	4	a5b6c3d58f7a8e533330798b81496009a31548af
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C2orf80 ADAMTSL1 GSTK1 FBXO31	1.91e-05	173	41	4	cc094992b8027f4cef38f0fb0b76f0d07210d1e2
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	KDR CTIF SLFN5 AGRN	1.96e-05	174	41	4	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	GPD2 GRB2 FIG4 PIK3R5	2.94e-05	193	41	4	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKR1E2 FIG4 DENND1A PIK3R5	3.24e-05	198	41	4	e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKR1E2 FIG4 DENND1A PIK3R5	3.24e-05	198	41	4	0baeb8e2c199ff10bb5c829c523546af3c9227c1
Disease	prostate adenocarcinoma (is_implicated_in)	GRB2 IGF1R	3.52e-04	20	41	2	DOID:2526 (is_implicated_in)
Disease	Colorectal Carcinoma	CHL1 PARP1 DNAH3 KDR PIK3R5 VPS13A	3.93e-04	702	41	6	C0009402
Disease	diabetes mellitus (implicated_via_orthology)	IGF1R WFS1	5.99e-04	26	41	2	DOID:9351 (implicated_via_orthology)
Disease	TYPE 2 DIABETES MELLITUS	GPD2 WFS1	6.96e-04	28	41	2	125853
Disease	Type 2 diabetes mellitus	GPD2 WFS1	6.96e-04	28	41	2	cv:C0011860
Disease	lysophosphatidylethanolamine 20:4 measurement	AKR1E2 PIK3R5	7.47e-04	29	41	2	EFO_0010370

Protein segments in the cluster

Peptide	Gene	Start	Entry
IEKVLPAWQGYHPMP	CTIF	161	O43310
WEELKIPLHGRPIYP	C2orf80	66	Q0P641
PPYLWPAHKNELMLN	AGRN	121	O00468
PEKPQLGMIDRWYHP	PARP1	146	P09874
APLPIMLPVYKWWQL	GPD2	156	P43304
PKGLPPLHIYWMNIE	CHL1	156	O00533
KQIMPYDLYHPLPRW	ADAMTSL1	366	Q8N6G6
KWPEPENPNGLILMY	IGF1R	851	P08069
VWLGMPSPIPAKYID	EFHC2	721	Q5JST6
GLFIIGWMYLPPHDP	FBXO31	166	Q5XUX0
PILLGDHMQKWIPPY	LPO	431	P22079
PAQPQIYPWMRKLHI	HOXA5	171	P20719
LPPWLKTEIPMGKNY	LIAS	76	O43766
GFIPKNYIEMKPHPW	GRB2	46	P62993
PPWDIHMELPYGTLT	METTL3	396	Q86U44
VMYPSKETAHWKPPP	NDUFS2	51	O75306
IYMEPHQLGWKPLKD	DNAH3	1851	Q8TD57
WMLKALPPALQDPPH	C21orf58	261	P58505
PPEHTIVYIPWDMAK	FIG4	406	Q92562
EKLWRPMHLGAVPVY	FUT11	291	Q495W5
LAHLLGEKWMGPIPP	GSTK1	206	Q9Y2Q3
MYWQHVYIPVLPPHL	DENND1A	221	Q8TEH3
PPHLEWNPRIKEVYM	CCDC168	3861	Q8NDH2
LVIMWQKHYVYGPLP	COX4I1	116	P13073
HPLIPTDYIKNLPMW	RNF103	501	O00237
IPMGLNKHWVDPLPD	DHX8	501	Q14562
KWMPPEKPNGIIINY	USH2A	3886	O75445
YLIPRHWIPKMNPTI	TDO2	371	P48775
LDLYLIHWPMGFKPP	AKR1E2	96	Q96JD6
HLKLTMYPWGLPPSH	NDUFV1-DT	121	Q8NBR9
HKVPPPWLIAMQRYG	SF3B2	626	Q13435
IQEPALPPGWEMKYT	WWP2	441	O00308
LPYIMHLWPPILLRN	VPS13A	2101	Q96RL7
YIMTYHEKPWLPPPL	TRPM6	1091	Q9BX84
PWYERNVLGLMHLPP	PIK3R5	616	Q8WYR1
PEYIQKLMPPLIQKW	TNPO2	556	O14787
LTWYKLGPQPLPIHV	KDR	581	P35968
PHNLPIVAGWKKYPL	SLC36A4	261	Q6YBV0
NLPPGSLVMLYEPKW	SLFN5	736	Q08AF3
PPAVQMLFHYWPNLK	UNC79	271	Q9P2D8
MLFHYWPNLKPPGAI	UNC79	276	Q9P2D8
LPSMPLNWPYLKVLG	WFS1	471	O76024