Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF823 HIVEP3 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF451 ZBTB43 ZNF816 ZNF70 ZNF888 ZNF624 ZNF75A ZNF616 ZNF510 ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZNF563 ZNF445	9.48e-19	1412	80	34	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF823 HIVEP3 BMI1 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZBTB43 ZNF816 ZNF70 ZNF888 ZNF624 ZNF75A ZNF616 ZNF510 ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZNF563 ZNF445	2.61e-18	1459	80	34	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HIVEP3 BMI1 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZBTB43 ZNF816 ZNF888 ZNF624 ZNF616 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZNF445	1.34e-13	1244	80	27	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	HIVEP3 BMI1 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZBTB43 ZNF816 ZNF888 ZNF624 ZNF616 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZNF445	2.24e-13	1271	80	27	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	BNC1 ZNF836 CTCFL ZNF600 ZFAT ZNF33B ZNF175 ZNF624 PRDM16 PRDM15 ZNF726 ZNF445	2.49e-06	566	80	12	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF836 CTCFL ZNF600 ZFAT ZNF33B ZNF175 ZNF624 PRDM16 PRDM15 ZNF726 ZNF445	1.39e-05	560	80	11	GO:0001228
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	MFAP5 EMILIN3	1.02e-03	12	80	2	GO:0030023
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	MFAP5 EMILIN3	1.40e-03	14	80	2	GO:0097493
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF28 ZNF175 PRDM5 ZNF844 PRDM16 ZNF726	1.80e-03	320	80	6	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF28 ZNF175 PRDM5 ZNF844 PRDM16 ZNF726	1.97e-03	326	80	6	GO:0001217
GeneOntologyMolecularFunction	SUMO binding	RNF4 HERC2	2.59e-03	19	80	2	GO:0032183
GeneOntologyMolecularFunction	zinc ion binding	TRIM46 ZCCHC24 BMI1 CDIP1 TRAF3 RNF4 UBR3 HERC2 ENPEP ZFPM2	2.89e-03	891	80	10	GO:0008270
Domain	zf-C2H2	ZNF823 HIVEP3 BNC1 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF451 ZBTB43 ZNF816 ZNF70 ZNF624 ZNF75A ZNF616 ZNF510 POGZ ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZFPM2 ZNF563 ZNF445	2.91e-29	693	85	36	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF823 HIVEP3 BNC1 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF451 ZBTB43 ZNF816 ZNF70 ZNF624 ZNF75A ZNF616 ZNF510 POGZ ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZFPM2 ZNF563 ZNF445	1.45e-27	775	85	36	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF823 HIVEP3 BNC1 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF451 ZBTB43 ZNF816 ZNF70 ZNF624 ZNF75A ZNF616 ZNF510 POGZ ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZFPM2 ZNF563 ZNF445	1.59e-27	777	85	36	PS00028
Domain	Znf_C2H2-like	ZNF823 HIVEP3 BNC1 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF451 ZBTB43 ZNF816 ZNF70 ZNF624 ZNF75A ZNF616 ZNF510 POGZ ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZFPM2 ZNF563 ZNF445	3.67e-27	796	85	36	IPR015880
Domain	Znf_C2H2	ZNF823 HIVEP3 BNC1 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF451 ZBTB43 ZNF816 ZNF70 ZNF624 ZNF75A ZNF616 ZNF510 POGZ ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZFPM2 ZNF563 ZNF445	5.42e-27	805	85	36	IPR007087
Domain	ZnF_C2H2	ZNF823 HIVEP3 BNC1 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF451 ZBTB43 ZNF816 ZNF70 ZNF624 ZNF75A ZNF616 ZNF510 POGZ ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZFPM2 ZNF563 ZNF445	6.17e-27	808	85	36	SM00355
Domain	-	ZNF823 HIVEP3 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZBTB43 ZNF816 ZNF70 ZNF624 ZNF75A ZNF616 ZNF510 ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZFPM2 ZNF563 ZNF445	9.98e-26	679	85	33	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF823 HIVEP3 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZBTB43 ZNF816 ZNF70 ZNF624 ZNF75A ZNF616 ZNF510 ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZFPM2 ZNF563 ZNF445	2.00e-25	694	85	33	IPR013087
Domain	KRAB	ZNF823 ZNF133 ZNF135 ZNF836 ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF816 ZNF624 ZNF75A ZNF616 ZNF510 ZFP69 ZNF626 ZNF844 ZIM3 ZNF726 ZNF563 ZNF445	3.65e-19	358	85	22	PS50805
Domain	KRAB	ZNF823 ZNF133 ZNF135 ZNF836 ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF816 ZNF624 ZNF75A ZNF616 ZNF510 ZFP69 ZNF626 ZNF844 ZIM3 ZNF726 ZNF563 ZNF445	3.65e-19	358	85	22	PF01352
Domain	KRAB	ZNF823 ZNF133 ZNF135 ZNF836 ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF816 ZNF624 ZNF75A ZNF616 ZNF510 ZFP69 ZNF626 ZNF844 ZIM3 ZNF726 ZNF563 ZNF445	6.99e-19	369	85	22	SM00349
Domain	KRAB	ZNF823 ZNF133 ZNF135 ZNF836 ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF816 ZNF624 ZNF75A ZNF616 ZNF510 ZFP69 ZNF626 ZNF844 ZIM3 ZNF726 ZNF563 ZNF445	7.40e-19	370	85	22	IPR001909
Domain	zf-C2H2_6	ZNF823 ZNF133 ZNF135 ZNF836 ZNF600 ZNF354A ZNF728 ZNF816 ZNF624 ZNF75A ZNF616 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 ZIM3 ZNF726 ZNF445	1.76e-16	314	85	19	PF13912
Domain	NPIP	NPIPB8 NPIPB13 NPIPB6 NPIPB3 NPIPB5 NPIPA2	2.17e-11	14	85	6	IPR009443
Domain	Sugar_P_trans_dom	SLC35E2A SLC35E2B	9.00e-04	10	85	2	IPR004853
Domain	TPT	SLC35E2A SLC35E2B	9.00e-04	10	85	2	PF03151
Domain	SET	PRDM5 PRDM16 PRDM15	1.20e-03	46	85	3	SM00317
Domain	SET_dom	PRDM5 PRDM16 PRDM15	1.53e-03	50	85	3	IPR001214
Domain	SET	PRDM5 PRDM16 PRDM15	1.53e-03	50	85	3	PS50280
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	HIVEP3 BMI1 ZNF133 ZNF135 ZNF600 ZNF28 ZNF354A ZNF33B ZNF41 ZNF175 ZNF70 ZNF624 ZNF75A ZNF616 ZNF510 MAPK3 ZFP69 ZNF626 ZIM3 ZNF726 ZNF563 ZNF445	7.02e-09	1387	57	22	M734
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	ZNF836 ZNF28 ZNF354A ZNF616 ZNF726	2.95e-06	56	57	5	MM17236
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF823 BMI1 ZNF836 ZNF28 ZNF354A ZNF624 ZNF616 MAPK3 ZFP69 ZNF844 ZNF726 ZNF563 ZNF445	8.86e-06	768	57	13	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF823 BMI1 ZNF836 ZNF28 ZNF354A ZNF624 ZNF616 MAPK3 ZFP69 ZNF844 ZNF726 ZNF563 ZNF445	1.73e-04	1022	57	13	MM15436
Pathway	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION	ZNF836 ZNF28 ZNF354A ZNF616 ZNF726	2.17e-04	136	57	5	MM14848
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF836 ZNF175 ZNF624 ZNF616 ZNF844 ZNF726 ZNF445	4.82e-11	49	90	7	9630514
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF354A ZNF33B ZNF41 ZNF728 ZNF624 ZNF626 ZNF726 ZNF563 ZNF445	1.13e-09	181	90	9	37372979
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	HIVEP3 ZNF836 LIMD1 ZNF175 ZNF451 ZBTB43 ZNF616 POGZ ZNF626 PRDM5 ZNF844 PRDM16 ZNF726 ZNF445	2.11e-08	808	90	14	20412781
Pubmed	Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.	BMI1 ZNF836 ZNF624 ZNF616 ZFPM2	5.06e-07	60	90	5	18023262
Pubmed	SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma.	SLC35E2A SLC35E2B	6.62e-06	2	90	2	35247439
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF624 ZFP69 ZNF726	1.85e-05	20	90	3	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF624 ZFP69 ZNF726	1.85e-05	20	90	3	2542606
Pubmed	An NF-κB-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium.	MAPK3 CXCL8	1.98e-05	3	90	2	22094458
Pubmed	Protease-activated receptor (PAR)-induced interleukin-8 production in airway epithelial cells requires activation of MAP kinases p44/42 and JNK.	MAPK3 CXCL8	1.98e-05	3	90	2	18086557
Pubmed	Oxidative stress induces extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase in cystic fibrosis lung epithelial cells: Potential mechanism for excessive IL-8 expression.	MAPK3 CXCL8	1.98e-05	3	90	2	17936667
Pubmed	LTD₄ induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells.	HBEGF CXCL8	1.98e-05	3	90	2	20889674
Pubmed	Methylation of PRDM2, PRDM5 and PRDM16 genes in lung cancer cells.	PRDM5 PRDM16	1.98e-05	3	90	2	24966940
Pubmed	Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.	PRKD1 MAPK3	1.98e-05	3	90	2	19804826
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	1.98e-05	3	90	2	11948212
Pubmed	CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells.	MAPK3 CXCL8	1.98e-05	3	90	2	12637525
Pubmed	Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells.	MAPK3 CXCL8	1.98e-05	3	90	2	15321994
Pubmed	Shared and distinct genetic variants in type 1 diabetes and celiac disease.	IL21 UBASH3A IL18RAP	2.15e-05	21	90	3	19073967
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	COMMD4 ZNF175 SLC35E2A POGZ SLC35E2B ZFP69	2.22e-05	217	90	6	34048709
Pubmed	Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.	PRDM5 PRDM16 PRDM15	2.49e-05	22	90	3	19050759
Pubmed	Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis.	MAPK3 CXCL8	3.96e-05	4	90	2	18830271
Pubmed	The IL sequence in the LLKIL motif in CXCR2 is required for full ligand-induced activation of Erk, Akt, and chemotaxis in HL60 cells.	MAPK3 CXCL8	3.96e-05	4	90	2	16990258
Pubmed	Interleukin(IL)-4 promotion of CXCL-8 gene transcription is mediated by ERK1/2 pathway in human pulmonary artery endothelial cells.	MAPK3 CXCL8	3.96e-05	4	90	2	21645924
Pubmed	Protein Tyrosine Phosphatase SHP-2 Is Involved in the Interleukin-21-Induced Activation of Extracellular Signal-Regulated Kinase 1/2.	IL21 MAPK3	3.96e-05	4	90	2	29503347
Pubmed	HB-EGF synthesis and release induced by cholesterol depletion of human epidermal keratinocytes is controlled by extracellular ATP and involves both p38 and ERK1/2 signaling pathways.	HBEGF MAPK3	3.96e-05	4	90	2	21413023
Pubmed	Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity.	MAPK3 CXCL8	3.96e-05	4	90	2	28247965
Pubmed	Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2.	TRAF3 MAPK3	3.96e-05	4	90	2	8626767
Pubmed	Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.	MAPK3 CXCL8	6.59e-05	5	90	2	18703508
Pubmed	Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells.	PRKD1 CXCL8	6.59e-05	5	90	2	19176759
Pubmed	Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.	TRAF3 CXCL8	6.59e-05	5	90	2	12169272
Pubmed	Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL-8 secretion.	MAPK3 CXCL8	6.59e-05	5	90	2	11884401
Pubmed	Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases.	HBEGF CXCL8	6.59e-05	5	90	2	16687414
Pubmed	Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways.	MAPK3 CXCL8	6.59e-05	5	90	2	25816245
Pubmed	Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways.	MAPK3 CXCL8	9.87e-05	6	90	2	19608729
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	TRIM46 BMI1 UBR3 HERC2	1.12e-04	95	90	4	29643511
Pubmed	Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytes.	MAPK3 CXCL8	1.38e-04	7	90	2	10982368
Pubmed	Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome drug candidate, blocks neuroinflammatory signalling by targeting the transactivator of transcription (Tat) protein.	PRKD1 MAPK3	1.38e-04	7	90	2	16539678
Pubmed	IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells.	MAPK3 CXCL8	1.38e-04	7	90	2	18065201
Pubmed	Detecting rare variants for complex traits using family and unrelated data.	ZFAT ZBTB43	1.38e-04	7	90	2	19847924
Pubmed	Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells.	BMI1 ENPEP	1.38e-04	7	90	2	21400497
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	TRIM46 BMI1 RNF4 UBR3	1.64e-04	105	90	4	22493164
Pubmed	Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease.	IL21 IL18RAP	1.84e-04	8	90	2	18805825
Pubmed	HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2.	MAPK3 CXCL8	1.84e-04	8	90	2	22904195
Pubmed	The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.	IL21 MAPK3	2.36e-04	9	90	2	17938255
Pubmed	A human MAP kinase interactome.	ZNF823 ZNF600 RNF4 ZNF175 ZNF451 POGZ HERC2	2.74e-04	486	90	7	20936779
Pubmed	Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.	HERC2 IL18RAP	2.94e-04	10	90	2	20176734
Pubmed	A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.	BMI1 PRKD1	3.59e-04	11	90	2	24623306
Pubmed	Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort.	IL21 IL18RAP	3.59e-04	11	90	2	19693089
Pubmed	Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.	SLC35E2A POGZ SLC35E2B	4.21e-04	56	90	3	9455484
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	BMI1 ZNF354A RNF4 ZNF41 ZNF175 ZNF451 ZBTB43 ZNF70 PRDM5	4.52e-04	877	90	9	20211142
Pubmed	TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src.	TRAF3 MAPK3	5.07e-04	13	90	2	10635328
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	ZNF624 ZFP69 ZNF726	5.41e-04	61	90	3	8662221
Pubmed	Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.	UBASH3A IL18RAP	5.91e-04	14	90	2	20647273
Pubmed	Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.	TRIM46 BMI1 RNF4 UBR3	6.21e-04	149	90	4	19549727
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LRCH2 ZNF451 ZBTB43 POGZ VPS13B PDZD2	6.74e-04	407	90	6	12693553
Pubmed	Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes.	MAPK3 CXCL8	6.80e-04	15	90	2	25064159
Pubmed	HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes.	MAPK3 CXCL8	6.80e-04	15	90	2	26031809
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF133 ZNF135	8.78e-04	17	90	2	7557990
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF14 PRAMEF13	9.86e-04	18	90	2	23894331
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF14 PRAMEF13	9.86e-04	18	90	2	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF14 PRAMEF13	9.86e-04	18	90	2	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF14 PRAMEF13	9.86e-04	18	90	2	14675769
Pubmed	Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation.	BMI1 MAPK3	9.86e-04	18	90	2	21675959
Pubmed	Newly identified genetic risk variants for celiac disease related to the immune response.	IL21 IL18RAP	1.10e-03	19	90	2	18311140
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF14 PRAMEF13	1.10e-03	19	90	2	28604677
Pubmed	Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.	TERB1 EMILIN3	1.10e-03	19	90	2	17660561
Pubmed	Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis.	PRKD1 PRDM16	1.10e-03	19	90	2	20660060
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	TRIM46 BNC1 ZNF135 ZNF28 NPIPB12 ZNF451 PRKD1 HERC2 PRDM15 ZNF726	1.19e-03	1215	90	10	15146197
Pubmed	Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway.	PRKD1 MAPK3	1.22e-03	20	90	2	11044099
Pubmed	Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation.	LIMD1 ZNF844	1.22e-03	20	90	2	12447396
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF14 PRAMEF13	1.22e-03	20	90	2	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF14 PRAMEF13	1.22e-03	20	90	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF14 PRAMEF13	1.22e-03	20	90	2	21425410
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF14 PRAMEF13	1.48e-03	22	90	2	31729367
Pubmed	Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.	BMI1 MAPK3	1.48e-03	22	90	2	28094771
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HIVEP3 ZNF133 EOGT ZNF33B RNF4 LIMD1 PRKD1 PRDM15 VPS13B DNAH1 PDZD2	1.60e-03	1489	90	11	28611215
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF14 PRAMEF13	1.62e-03	23	90	2	19480014
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	NPIPB8 NPIPB11 NPIPB3	1.67e-03	90	90	3	15616553
Pubmed	Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues.	MAPK3 PRDM16	1.76e-03	24	90	2	28324027
Pubmed	Tagging genes with cassette-exchange sites.	ZFAT MAPK3 MCM10 PRDM5 ZNF726	1.81e-03	335	90	5	15741177
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF14 PRAMEF13	1.91e-03	25	90	2	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF14 PRAMEF13	1.91e-03	25	90	2	12620990
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF14 PRAMEF13	2.07e-03	26	90	2	18500982
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	LRCH2 NBEAL1 NPIPB11 ZNF451 ZBTB43 MCM10 PRDM15	2.10e-03	689	90	7	36543142
Pubmed	Identification of differentially expressed genes in mouse spermatogenesis.	ZNF836 ZNF616	2.23e-03	27	90	2	14581517
Pubmed	Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.	PRKD1 MAPK3	2.23e-03	27	90	2	20336759
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF14 PRAMEF13	2.40e-03	28	90	2	25089626
Pubmed	A census of human transcription factors: function, expression and evolution.	HIVEP3 BNC1 CTCFL ZNF28 ZNF175 ZNF451 PRDM5 ZFPM2	2.46e-03	908	90	8	19274049
Pubmed	EBF2 determines and maintains brown adipocyte identity.	PRDM16 ENPEP	2.57e-03	29	90	2	23499423
Pubmed	Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.	ZNF135 LIMD1	2.57e-03	29	90	2	21834987
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF626 ZNF726	2.57e-03	29	90	2	14563677
Cytoband	19q13.41	ZNF836 ZNF600 ZNF28 ZNF816 ZNF888 ZNF616	1.10e-08	78	90	6	19q13.41
Cytoband	16p11.2	NPIPB8 NPIPB13 NPIPB12 NPIPB6 NPIPB11 MAPK3	2.23e-06	191	90	6	16p11.2
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	5.39e-05	37	90	3	16p12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p11	NPIPB8 NPIPB13 NPIPB12 NPIPB11 MAPK3	2.27e-04	278	90	5	chr16p11
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB4 NPIPB6 NPIPB3 NPIPB5	3.78e-04	172	90	4	chr16p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF135 ZNF836 ZNF600 ZNF28 ZNF175 ZNF816 ZNF888 ZNF616 ZIM3	5.60e-04	1192	90	9	chr19q13
Cytoband	19p12	ZNF728 ZNF626 ZNF726	7.57e-04	90	90	3	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr4q27	IL21 PRDM5	1.81e-03	32	90	2	chr4q27
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF728 ZNF626 ZNF726	1.82e-03	122	90	3	chr19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	ARHGEF19 SLC35E2A PRAMEF14 SLC35E2B PRAMEF13 PRDM16	2.26e-03	681	90	6	chr1p36
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF823 HIVEP3 BNC1 ZNF133 ZNF135 ZNF836 CTCFL ZNF600 ZFAT ZNF28 ZNF354A ZNF33B ZNF41 ZNF728 ZNF175 ZNF451 ZBTB43 ZNF816 ZNF70 ZNF888 ZNF624 ZNF75A ZNF616 ZNF510 ZFP69 ZNF626 PRDM5 ZNF844 ZNF883 PRDM16 PRDM15 ZIM3 ZNF726 ZFPM2 ZNF563 ZNF445	5.76e-33	718	67	36	28
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM5 PRDM16 PRDM15	3.19e-05	17	67	3	1197
GeneFamily	PRAME family	PRAMEF14 PRAMEF13	3.54e-03	24	67	2	686
Disease	Streptococcal pneumonia	MAPK3 CXCL8	1.14e-04	6	82	2	C0155862
Disease	tropical spastic paraparesis (is_marker_for)	IL21 CXCL8	2.71e-04	9	82	2	DOID:321 (is_marker_for)
Disease	Asthma, Occupational	PRKD1 HERC2	3.38e-04	10	82	2	C0264423
Disease	CXCL5 measurement	NALF1 ZFPM2	3.38e-04	10	82	2	EFO_0009422
Disease	advanced glycosylation end product-specific receptor, soluble measurement	PRDM16 ZFPM2	5.83e-04	13	82	2	EFO_0020131
Disease	Cardiotoxicity	HBEGF CXCL8	5.83e-04	13	82	2	C0876994
Disease	Ulcerative Colitis	HERC2 IL18RAP CXCL8	7.28e-04	63	82	3	C0009324
Disease	C-X-C motif chemokine 6 measurement	ZFPM2 CXCL8	8.93e-04	16	82	2	EFO_0008059
Disease	Mechanical Allodynia	SCN11A MAPK3 CXCL8	1.68e-03	84	82	3	C2936719
Disease	Allodynia	SCN11A MAPK3 CXCL8	1.68e-03	84	82	3	C0458247
Disease	Hyperalgesia, Secondary	SCN11A MAPK3 CXCL8	1.68e-03	84	82	3	C0751212
Disease	Hyperalgesia, Primary	SCN11A MAPK3 CXCL8	1.68e-03	84	82	3	C0751211
Disease	Hyperalgesia, Thermal	SCN11A MAPK3 CXCL8	1.68e-03	84	82	3	C0751214
Disease	Tactile Allodynia	SCN11A MAPK3 CXCL8	1.68e-03	84	82	3	C0751213
Disease	Hyperalgesia	SCN11A MAPK3 CXCL8	1.68e-03	84	82	3	C0020429
Disease	Hepatic Form of Wilson Disease	ASMT CXCL8	2.02e-03	24	82	2	C1527352
Disease	Hepatolenticular Degeneration	ASMT CXCL8	2.02e-03	24	82	2	C0019202
Disease	eye color	HIVEP3 HERC2 ENPEP	2.04e-03	90	82	3	EFO_0003949

Protein segments in the cluster

Peptide	Gene	Start	Entry
HIATVCRKDSLCPYK	EOGT	56	Q5NDL2
VCPHCQQAITTKISY	CDIP1	141	Q9H305
PKYQCPHCATIIARK	CTCFL	426	Q8NI51
VETPKCLCKVHLYEQ	CPED1	611	A4D0V7
LPITCHLCQKTYSNK	BNC1	926	Q01954
KCSHLLERIYHTCKP	ASMT	261	P46597
MRLPIHCVCVTKEYS	NBEAL1	2626	Q6ZS30
QHVKSVTCPCEYLRK	NPIPB3	26	Q92617
THSEKRPYNCEICNK	PRDM5	341	Q9NQX1
IRTHTREKPYKCSEC	PRDM5	536	Q9NQX1
QHVKSVTCPCEYLRK	NPIPB12	26	F8W0I5
DCPQVQCVRTYKALH	ARHGEF19	716	Q8IW93
DIRKSYPHIIQDKCT	IL18RAP	96	O95256
HSYTRPTVCQYCKKL	PRKD1	276	Q15139
VRDYHKVLAPKCAAC	LIMD1	586	Q9UGP4
ATCKYNACHVVPIKN	GTSF1L	41	Q9H1H1
CRVVYQAKCSLIKTH	HERC2	1481	O95714
SPKRLLDYHECTVCK	ZFPM2	846	Q8WW38
KYCPICDVQVHKTRP	BMI1	51	P35226
CLVTDKIKVTRRHYC	PDZD2	2306	O15018
QHVKSVTCPCEYLRK	NPIPB8	26	E9PQR5
QHVKSVTCPCEYLRK	NPIPB5	26	A8MRT5
KKISPFEHQTYCQRT	MAPK3	71	P27361
VKCRVVTCKTCAYTH	MCM10	776	Q7L590
RYCIQTKHVAILCAV	ENPEP	11	Q07075
QHVKSVTCPCEYLRK	NPIPA2	26	E9PIF3
QHVKSVTCPCEYLRK	NPIPB4	26	C9JG80
CTRLYSVHRPVKQCI	MFAP5	91	Q13361
QHVKSVTCPCEYLRK	NPIPB11	26	E5RHQ5
QVCVYIHQSVSKKCI	DNAH1	2776	Q9P2D7
HANCTLIISYQKPKE	DPCD	161	Q9BVM2
QKHRLTCPSCDSYEK	IL21	116	Q9HBE4
LCRCYEEKQSPLQKH	COMMD4	106	Q9H0A8
LCDACQKVYLRVPSH	DSC1	26	Q08554
KALCAYVVHRNVTCI	EMILIN3	56	Q9NT22
CKYVKELRAPSCICH	HBEGF	121	Q99075
PETLCFCTHRYKQHK	FAM221A	71	A4D161
QHVKSVTCPCEYLRK	NPIPB6	26	E9PJ23
CNKVTEIPVCYRKLH	LRCH2	256	Q5VUJ6
CCSKLVNYLTPIKHL	PRAMEF13	181	Q5VWM6
QHVKSVTCPCEYLRK	NPIPB13	26	A6NJU9
KEEVTHYCKTCQRLV	TRIM46	231	Q7Z4K8
CCSKLVNYLTPIKHL	PRAMEF14	181	Q5SWL7
DSEPHKYSCKRCQLT	PRDM15	986	P57071
NVHSPYESTTKCKIC	POGZ	551	Q7Z3K3
TRHLLCPYCLKVFKN	POGZ	616	Q7Z3K3
VKPFICEVCHKSYTQ	PRDM16	391	Q9HAZ2
VKTLVPCCLYQHKAR	SLC35E2A	121	P0CK97
CKECRIAHPVVKCTY	FAM76A	26	Q8TAV0
IHTGIKPYECNICAK	ZBTB43	421	O43298
RTHTVEKPYECKTCR	ZNF823	491	P16415
VPFQVKCVACHKTLR	ZNF451	311	Q9Y4E5
QRIHTKEKPYQCNVC	ZNF624	351	Q9P2J8
QRIHTGEKPYKCSIC	ZIM3	326	Q96PE6
YKCEKCHLVLCSPKQ	TRAF3	51	Q13114
KYREATCSHCKSQVP	TRAF3	171	Q13114
RIHTNEKPYKCPQCS	ZFAT	291	Q9P243
VSPHIREKTYVCNEC	ZNF616	176	Q08AN1
QRIHTGEKPYKCTQC	ZNF135	261	P52742
QRTHTQEKPYKCNEC	ZNF33B	656	Q06732
NTCPTCRKKINHKRY	RNF4	171	P78317
ALIHKIPYGQCTIAC	SPPL2A	266	Q8TCT8
KVNVVTCTKHTYRCL	ST14	561	Q9Y5Y6
LTYKRIHTGEKPCKC	ZNF728	216	P0DKX0
YCSRPCAKPSVLQKH	HIVEP3	196	Q5T1R4
VKTLVPCCLYQHKAR	SLC35E2B	121	P0CK96
KAFKCPSYLCRHEVT	ZNF844	316	Q08AG5
PRKICQCDKYVKVLH	ZNF626	141	Q68DY1
QRTHSKEKPYVCGVC	ZNF133	401	P52736
IHTREKPYKCEECSK	ZNF726	446	A6NNF4
IVIHTREKPYKCNEC	ZNF888	401	P0CJ79
KAFVYPSVCQRHEKT	ZNF563	456	Q8TA94
KTHTREKPYVCNLCG	ZNF70	411	Q9UC06
IIHTGKKPYACTECQ	ZNF41	781	P51814
QRIHTQEKPYKCTKC	ZNF445	616	P59923
YHRKTCSVCTKVPKD	UBR3	1761	Q6ZT12
CKKIPSECSIHHELY	VPS13B	3281	Q7Z7G8
TIIHTGEKPYKCNEC	ZNF28	346	P17035
QRIHTAEKPYKCNEC	ZNF510	451	Q9Y2H8
ACSIQYECKHTKINP	SCN11A	321	Q9UI33
TEHLKIHSCVKPYQC	ZNF883	281	P0CG24
QITHTGEKPYICKEC	ZNF354A	261	O60765
RIHTEEKPYKCQQCD	ZNF75A	181	Q96N20
TRIHTAEKPYKCNEC	ZNF600	601	Q6ZNG1
LHSCPYQCDRHKVIV	TERB1	611	Q8NA31
LRIHTGQKPYKCNVC	ZNF836	601	Q6ZNA1
TRVHTGEKPYKCNKC	ZNF816	556	Q0VGE8
QITHTRERPFVCYKC	ZNF175	606	Q9Y473
QKYCSVKPCTKQLHL	UBASH3A	221	P57075
YECNICEKIFKQPIH	ZFP69	271	Q49AA0
ECIKCHINVYPHKQR	ZCCHC24	191	Q8N2G6
ELRCQCIKTYSKPFH	CXCL8	31	P10145
KTIPCKQYCLEVQTR	NALF1	326	B1AL88