Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncadherin binding

MICALL1 IST1 ITGA6 EXOC3 ERC1 GOLGA2 CDH17

9.96e-06339457GO:0045296
GeneOntologyMolecularFunctiontranscription corepressor activity

SSX9P SSX6P SSX7 SSX1 SSX3 SSX5

1.19e-05229456GO:0003714
GeneOntologyMolecularFunctioncell adhesion molecule binding

MICALL1 IST1 ITGA6 EXOC3 DSP ERC1 GOLGA2 CDH17

5.06e-05599458GO:0050839
GeneOntologyMolecularFunctiontranscription coregulator activity

NUP98 SSX9P SSX6P SSX7 SSX1 SSX3 SSX5

2.42e-04562457GO:0003712
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

NUP98 FBXO38 SSX9P SSX6P SSX7 SSX1 SSX3 SSX5 IQCB1

9.71e-041160459GO:0030674
GeneOntologyCellularComponentsperm flagellum

DNAH2 SSX9P SSX6P SSX7 SSX1 SSX3 SSX5

3.48e-07214457GO:0036126
GeneOntologyCellularComponent9+2 motile cilium

DNAH2 SSX9P SSX6P SSX7 SSX1 SSX3 SSX5

7.13e-07238457GO:0097729
GeneOntologyCellularComponentmotile cilium

DNAH2 SSX9P SSX6P SSX7 SSX1 SSX3 SSX5

1.00e-05355457GO:0031514
GeneOntologyCellularComponentcilium

DNAH2 PCDH15 SSX9P SSX6P SSX7 SSX1 SSX3 SSX5 ERC1 IQCB1

1.65e-058984510GO:0005929
GeneOntologyCellularComponentmitotic spindle

HAUS4 WAPL GOLGA2 IQCB1

9.08e-04201454GO:0072686
DomainKRAB_RELATED

SSX9P SSX6P SSX7 SSX1 SSX2 SSX3 SSX5

7.99e-1711447PS50806
DomainKrueppel-associated_box-rel

SSX9P SSX6P SSX7 SSX1 SSX2 SSX3 SSX5

4.14e-1613447IPR003655
DomainSSX

SSX7 SSX1 SSX2 SSX3 SSX5

3.44e-136445IPR028804
DomainSSXRD

SSX7 SSX1 SSX2 SSX3 SSX5

3.20e-128445PF09514
DomainSSXRD_motif

SSX7 SSX1 SSX2 SSX3 SSX5

3.20e-128445IPR019041
DomainKRAB

SSX9P SSX6P SSX7 SSX1 SSX2 SSX3 SSX5

2.27e-05369447SM00349
DomainKRAB

SSX9P SSX6P SSX7 SSX1 SSX2 SSX3 SSX5

2.31e-05370447IPR001909
Pubmed

The SSX gene family: characterization of 9 complete genes.

SSX9P SSX6P SSX7 SSX1 SSX2 SSX3 SSX5 SSX4

8.17e-192145812216073
Pubmed

Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression.

SSX9P SSX6P SSX7 SSX1 SSX3 SSX5

2.78e-16945614611804
Pubmed

The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.

SSX1 SSX2 SSX3 SSX5 SSX4

1.61e-13845512007189
Pubmed

SSX2-4 expression in early-stage non-small cell lung cancer.

SSX2 SSX3 SSX4

2.02e-09345324645645
Pubmed

The DNA sequence of the human X chromosome.

SSX9P GRIPAP1 SSX6P SSX7 SSX1 SSX2 SSX3 SSX5 SSX4

2.30e-0940745915772651
Pubmed

Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas.

SSX1 SSX2 SSX4

8.09e-09445312037676
Pubmed

Expressions of cancer-testis antigens in human hepatocellular carcinomas.

SSX7 SSX5 SSX4

8.09e-09445311179834
Pubmed

Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.

SSX2 SSX3 SSX5

8.09e-09445310749136
Pubmed

Molecular mechanisms underlying human synovial sarcoma development.

SSX6P SSX5 SSX4

8.09e-09445311107170
Pubmed

SSX: a multigene family with several members transcribed in normal testis and human cancer.

SSX3 SSX5 SSX4

2.02e-0854539378559
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NUP98 MICALL1 FBXO38 DIP2B WAPL DSP POLR2A CDH17 BAP1

5.53e-0777445915302935
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

DOCK4 EXOC3 HAUS4 GRIPAP1 DSP ERC1 GOLGA2 IQCB1

7.91e-0758845838580884
Pubmed

Molecular diagnosis of synovial sarcoma: RT-PCR detection of SYT-SSX1/2 fusion transcripts in paraffin-embedded tissue.

SSX1 SSX2

1.64e-06245215735574
Pubmed

Expression of cancer-testis antigen in multiple myeloma.

SSX1 SSX4

1.64e-06245224710929
Pubmed

Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma.

SSX2 SSX5

1.64e-06245216546222
Pubmed

[Analysis of SYT/SSX1 and SYT/SSX2 fusion genes from synovial sarcoma].

SSX1 SSX2

1.64e-06245222393780
Pubmed

A novel fluorescence in situ hybridization assay for synovial sarcoma.

SSX1 SSX2

1.64e-06245223623359
Pubmed

Steroid hormones and human choriogonadotropin influence the distribution of alpha6-integrin and desmoplakin 1 in gland-like endometrial epithelial spheroids.

ITGA6 DSP

1.64e-06245233502623
Pubmed

Truncated SSX protein suppresses synovial sarcoma cell proliferation by inhibiting the localization of SS18-SSX fusion protein.

SSX1 SSX2

4.91e-06345224130893
Pubmed

Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.

SSX1 SSX2

4.91e-0634527539744
Pubmed

Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas.

SSX1 SSX2

4.91e-0634527655467
Pubmed

Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma.

SSX1 SSX2

4.91e-06345216152617
Pubmed

Recurrent and novel SS18-SSX fusion transcripts in synovial sarcoma: description of three new cases.

SSX1 SSX2

4.91e-06345222976541
Pubmed

SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma.

SSX1 SSX2

4.91e-06345224166495
Pubmed

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.

SSX7 SSX1 SSX3 SSX5 KIF16B

6.83e-0620545512040188
Pubmed

Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression.

SSX2 SSX4

9.81e-06445211368913
Pubmed

Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma.

SSX1 SSX2

9.81e-0644527951320
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MICALL1 DOCK4 DIP2B CASC3 DSP ERC1 IQCB1 SPATA13

1.31e-0586145836931259
Pubmed

MICAL-1 isoforms, novel rab1 interacting proteins.

MICALL1 GOLGA2

1.63e-05545212788069
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

NUP98 ROBO1 DSP GOLGA2 POLR2A

2.00e-0525645533397691
Pubmed

The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis.

SSX1 SSX2

2.45e-05645226947017
Pubmed

Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.

ERC1 SPATA13

3.42e-05745223525008
Pubmed

Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells.

ITGA6 DSP

3.42e-05745218292208
Pubmed

The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain.

ITGA6 CDH17

4.56e-05845210906147
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

NUP98 ITGA6 FBXO38 EXOC3 ROBO1 DSP ERC1 POLR2A

5.34e-05104945827880917
Pubmed

Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.

PCDH15 ROBO1

5.86e-05945223144817
Pubmed

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

ITGA6 DSP

5.86e-05945212482924
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

MICALL1 IST1 ITGA6 EXOC3 ERC1 GOLGA2

8.51e-0556545625468996
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

ITGA6 DSP

8.94e-051145212802069
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

NUP98 FBXO38 EXOC3 HAUS4 WAPL GOLGA2 POLR2A BAP1

1.04e-04115545820360068
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

MICALL1 DOCK4 IST1 HAUS4 GRIPAP1 DSP ERC1

1.05e-0485345728718761
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

NUP98 SMG5 WAPL STK40 DSP POLR2A BAP1

1.08e-0485745725609649
Pubmed

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.

HAUS4 GOLGA2 SPATA13 BAP1 KIF16B

2.04e-0441945527107012
Pubmed

A physical interaction network of dengue virus and human proteins.

ERC1 GOLGA2

2.47e-041845221911577
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

MICALL1 XYLT2 EXOC3 HAUS4 GRIPAP1 NDUFA9 ERC1 IQCB1

2.61e-04132145827173435
Pubmed

Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.

ITGA6 DSP

2.76e-041945218166659
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

XYLT2 CASC3 SMG5 NDUFA9 ERC1

3.19e-0446245531138677
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

CASC3 ROBO1 GRIPAP1 WAPL POLR2A IQCB1

3.47e-0473345634672954
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

DNAH2 WAPL DSP ERC1 GOLGA2 POLR2A

4.04e-0475445635906200
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

ERC1 GOLGA2 KIF16B

4.07e-0411145322558309
Pubmed

CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes.

GOLGA2 POLR2A

4.82e-042545228768200
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MICALL1 HAUS4 SMG5 STK40 POLR2A SPATA13 BAP1

5.07e-04110545735748872
Pubmed

ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.

ERC1 POLR2A

5.22e-042645234162889
Pubmed

Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis.

ROBO1 GOLGA2

5.22e-042645231138815
Pubmed

Beclin 1 regulates recycling endosome and is required for skin development in mice.

ITGA6 GOLGA2

5.63e-042745230701202
Pubmed

Robo1 modulates proliferation and neurogenesis in the developing neocortex.

ITGA6 ROBO1

5.63e-042745224741061
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MICALL1 SMG5 WAPL BAP1 KIF16B

5.91e-0452945514621295
Pubmed

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

NUP98 GRIPAP1 ERC1 GOLGA2

5.97e-0429845432353859
Pubmed

Genome-wide association study of periodontal pathogen colonization.

FBXO38 WAPL

7.43e-043145222699663
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

NUP98 ROBO1 DSP ERC1 GOLGA2

8.14e-0456845537774976
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

MICALL1 ITGA6 EXOC3 DIP2B KIF16B

8.20e-0456945530639242
Pubmed

Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells.

NDUFA9 BAP1

8.43e-043345239181129
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

FBXO38 DIP2B WAPL POLR2A

8.92e-0433245432786267
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

ITGA6 ROBO1 ERC1 POLR2A

1.18e-0335845432460013
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

NUP98 GRIPAP1 ERC1 GOLGA2

1.20e-0336045433111431
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

NUP98 MICALL1 DOCK4 NDUFA9 DSP ERC1 POLR2A

1.22e-03128445717353931
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

NUP98 IST1 WAPL DSP ERC1 POLR2A

1.23e-0393445633916271
InteractionSSX2 interactions

SSX6P SSX7 SSX2 SSX3 SSX5

5.05e-0845455int:SSX2
InteractionSSX7 interactions

SSX7 SSX2 SSX3

1.70e-0611453int:SSX7
InteractionKRT8 interactions

DOCK4 HAUS4 GRIPAP1 DSP ERC1 IQCB1 BAP1 KIF16B

5.23e-06441458int:KRT8
InteractionCALB1 interactions

GRIPAP1 POLR2A IQCB1

8.29e-0618453int:CALB1
InteractionFBXO42 interactions

DOCK4 GRIPAP1 DSP ERC1 GOLGA2 IQCB1

2.28e-05259456int:FBXO42
InteractionPCM1 interactions

HAUS4 SMG5 NDUFA9 DSP ERC1 GOLGA2 IQCB1

4.58e-05434457int:PCM1
InteractionNEFM interactions

DSP ERC1 GOLGA2 IQCB1 BAP1

6.36e-05190455int:NEFM
InteractionSSX3 interactions

SSX7 SSX2 SSX3

7.05e-0536453int:SSX3
CytobandEnsembl 112 genes in cytogenetic band chrXp11

SSX9P GRIPAP1 SSX6P SSX7 SSX1 SSX2 SSX3 SSX5 SSX4

1.05e-10377459chrXp11
CytobandXp11.23

SSX9P SSX7 SSX1 SSX3 SSX5 SSX4

5.10e-1095456Xp11.23
Cytoband12p13.3

NDUFA9 ERC1

4.02e-043045212p13.3
CoexpressionMYLLYKANGAS_AMPLIFICATION_HOT_SPOT_1

SSX1 SSX2 SSX4

8.80e-086443M5931
CoexpressionNAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP

SSX1 SSX2 SSX3 SSX4

1.52e-0589444M2761
CoexpressionGSE17721_CTRL_VS_PAM3CSK4_1H_BMDC_DN

DIP2B ROBO1 GRIPAP1 STK40 SPATA13

2.05e-05199445M3731
CoexpressionMUELLER_METHYLATED_IN_GLIOBLASTOMA

SSX1 SSX2 SSX3

5.20e-0543443M912
CoexpressionKIM_RESPONSE_TO_TSA_AND_DECITABINE_UP

SSX1 SSX2 SSX3 SSX4

8.01e-05136444M126
DrugDB01888

SSX9P SSX7 SSX2 SSX4

5.05e-0819454CID005287990
Drug2d41

SSX1 SSX3 SSX5 SSX4

2.26e-0727454CID009543496
DrugA25618

SSX9P SSX6P SSX7 L3MBTL1 SSX1 SSX2 SSX3 SSX4 POLR2A LMLN

2.18e-067774510CID000005562
DrugPridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A

MICALL1 XYLT2 SMG5 GOLGA2 POLR2A

3.95e-051944557214_DN
DrugMorantel tartrate [26155-31-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A

MICALL1 ITGA6 SMG5 L3MBTL1 ERC1

4.15e-051964557010_UP
DrugDiazoxide [364-98-7]; Down 200; 17.4uM; PC3; HT_HG-U133A

NUP98 MICALL1 XYLT2 SMG5 SSX1

4.25e-051974555810_DN
Diseasesynovial sarcoma

SSX1 SSX2

2.68e-056402C0039101
Diseasetestosterone measurement

DNAH2 DOCK4 FBXO38 DIP2B CASC3 ZNF800 SUGCT POLR2A

2.66e-041275408EFO_0004908
DiseaseNecrotizing encephalopathy, infantile subacute, of Leigh

NDUFA9 GFM2

1.10e-0336402C2931891
DiseaseLeigh Syndrome due to Mitochondrial Complex V Deficiency

NDUFA9 GFM2

1.10e-0336402C1850600
DiseaseLeigh Syndrome due to Mitochondrial Complex III Deficiency

NDUFA9 GFM2

1.10e-0336402C1850598
DiseaseLeigh Syndrome Due To Mitochondrial Complex II Deficiency

NDUFA9 GFM2

1.10e-0336402C1850597
DiseaseLeigh Syndrome due to Mitochondrial Complex IV Deficiency

NDUFA9 GFM2

1.10e-0336402C1850599
DiseaseLEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY

NDUFA9 GFM2

1.16e-0337402C1838951
Diseaselysine measurement

ROBO1 NADK2

1.16e-0337402EFO_0005002

Protein segments in the cluster

PeptideGeneStartEntry
THILKEVLRYDDRAI

SUGCT

416

Q9HAC7
DRRIKYEARLHVLKV

BAP1

236

Q92560
VIAERRSHLEKYLRD

KIF16B

1256

Q96L93
RIQHLEREITRYKDE

ERC1

736

Q8IUD2
IVHIRRKEVVVYLDD

NUP98

791

P52948
VRLVKRREYDEETVR

NADK2

136

Q4G0N4
VKRDVDEHLRIKTVY

LMLN

86

Q96KR4
RLFKDEARIVRVTHV

L3MBTL1

771

Q9Y468
TVYVDLKSLRHDRVR

DIP2B

1336

Q9P265
EKHLLVRRESELIYV

MICALL1

731

Q8N3F8
PRYHAVRIRKEEREI

ITGA6

1091

P23229
VLKERHREKEEYISR

GOLGA2

856

Q08379
ELKAIEVLRRHRTYR

NDUFA9

346

Q16795
KEAVTLYLRVVRVVD

FBXO38

61

Q6PIJ6
GTIIYHEVRIVVRDR

PCDH15

126

Q96QU1
ETVKHEISYRSRRLE

CASC3

341

O15234
SELRKDIYITVHIIR

DOCK4

266

Q8N1I0
ITRLTYEIEDEKRRR

DSP

1111

P15924
RARIRVEHIIREDYL

IST1

51

P53990
VELKKRVDDYVRRHL

IQCB1

456

Q15051
YTVEKVEVHRLIRDR

HAUS4

291

Q9H6D7
AEAHRRVVVEYLRAV

EXOC3

596

O60645
LRHEKEVLGVRARYE

GRIPAP1

456

Q4V328
RHTEFEEREYVVLIR

CDH17

731

Q12864
LFREAIEHITRIVRV

DNAH2

2736

Q9P225
LRELSEVLREYRKEH

TMEM41A

51

Q96HV5
EIIHDRIKREYGLET

GFM2

541

Q969S9
HYVIKEKRLSERETV

STK40

161

Q8N2I9
KRLYRAVVEAVHRLD

SMG5

21

Q9UPR3
RAIYRIITHREEIIE

PLCZ1

61

Q86YW0
HRLRERKQLVIYEEI

SSX3

166

Q99909
HRLRERKQLVIYEEI

SSX1

166

Q16384
REIMDTERVYIKHLR

SPATA13

246

Q96N96
HRLRERKQLVIYEEI

SSX2

166

Q16385
HRLRERKQLVVYEEI

SSX4

166

O60224
HRVRERKQLVIYEEI

SSX5

166

O60225
HRLRERKQLVIYEEI

SSX6P

166

Q7RTT6
HRLRERKQLVIYEEI

SSX7

166

Q7RTT5
HRLRERKQLVIYEEI

SSX9P

166

Q7RTT3
IEAVRKALERELYHV

POLR2A

1371

P24928
RREDKELYTVVQHVK

WAPL

626

Q7Z5K2
RYEIRDDHTLKIRKV

ROBO1

306

Q9Y6N7
YETRRKRDVIRHITV

ZNF800

526

Q2TB10
VDKRSDYLHREVVEL

XYLT2

266

Q9H1B5
REMEVYIRHLEKVLR

VWA3A

921

A6NCI4