Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine binding	CHRFAM7A CHRNA7	3.81e-04	13	45	2	GO:0042166
GeneOntologyMolecularFunction	chloride channel regulator activity	CHRFAM7A CHRNA7	5.12e-04	15	45	2	GO:0017081
GeneOntologyMolecularFunction	adenylate cyclase binding	CHRFAM7A CHRNA7	5.84e-04	16	45	2	GO:0008179
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	CAPN1 CAPN3	6.61e-04	17	45	2	GO:0004198
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRFAM7A CHRNA7	6.61e-04	17	45	2	GO:0022848
GeneOntologyMolecularFunction	toxic substance binding	CHRFAM7A CHRNA7	7.43e-04	18	45	2	GO:0015643
GeneOntologyMolecularFunction	narrow pore channel activity	KCNK17 NALCN	8.29e-04	19	45	2	GO:0022842
GeneOntologyMolecularFunction	leak channel activity	KCNK17 NALCN	8.29e-04	19	45	2	GO:0022840
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRFAM7A CHRNA7	1.22e-03	23	45	2	GO:0015464
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	4.65e-06	2	45	2	GO:0001988
GeneOntologyBiologicalProcess	baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	1.39e-05	3	45	2	GO:0001982
GeneOntologyBiologicalProcess	generation of ovulation cycle rhythm	CHRFAM7A CHRNA7	2.78e-05	4	45	2	GO:0060112
GeneOntologyBiologicalProcess	sensory processing	CHRFAM7A CHRNA7	4.63e-05	5	45	2	GO:0050893
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback	CHRFAM7A CHRNA7	6.94e-05	6	45	2	GO:0001978
GeneOntologyBiologicalProcess	synaptic transmission, cholinergic	NALCN CHRFAM7A CHRNA7	1.21e-04	44	45	3	GO:0007271
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by baroreceptor feedback	CHRFAM7A CHRNA7	1.29e-04	8	45	2	GO:0003025
GeneOntologyBiologicalProcess	positive regulation of CoA-transferase activity	CHRFAM7A CHRNA7	1.66e-04	9	45	2	GO:1905920
GeneOntologyBiologicalProcess	regulation of CoA-transferase activity	CHRFAM7A CHRNA7	2.53e-04	11	45	2	GO:1905918
GeneOntologyBiologicalProcess	behavioral response to nicotine	CHRFAM7A CHRNA7	2.53e-04	11	45	2	GO:0035095
GeneOntologyBiologicalProcess	positive regulation of blood pressure	TBXA2R CHRFAM7A CHRNA7	2.90e-04	59	45	3	GO:0045777
GeneOntologyBiologicalProcess	regulation of synapse structural plasticity	CHRFAM7A CHRNA7	3.03e-04	12	45	2	GO:0051823
GeneOntologyBiologicalProcess	regulation of synaptic transmission, dopaminergic	CHRFAM7A CHRNA7	3.58e-04	13	45	2	GO:0032225
GeneOntologyBiologicalProcess	response to ethanol	TBXA2R CHRFAM7A ADCY7 CHRNA7	4.15e-04	161	45	4	GO:0045471
GeneOntologyBiologicalProcess	presynaptic modulation of chemical synaptic transmission	GRM8 CHRFAM7A CHRNA7	4.22e-04	67	45	3	GO:0099171
GeneOntologyBiologicalProcess	dendrite arborization	CHRFAM7A CHRNA7	4.80e-04	15	45	2	GO:0140059
GeneOntologyBiologicalProcess	self proteolysis	CAPN1 CAPN3	4.80e-04	15	45	2	GO:0097264
GeneOntologyBiologicalProcess	response to alcohol	TBXA2R CHRFAM7A ADCY7 CHRNA7 CDK4	5.71e-04	312	45	5	GO:0097305
GeneOntologyBiologicalProcess	behavioral response to ethanol	CHRFAM7A CHRNA7	6.20e-04	17	45	2	GO:0048149
GeneOntologyBiologicalProcess	regulation of amyloid fibril formation	CHRFAM7A CHRNA7	7.77e-04	19	45	2	GO:1905906
GeneOntologyCellularComponent	spine apparatus membrane	CHRFAM7A CHRNA7	1.42e-05	3	46	2	GO:0098897
GeneOntologyCellularComponent	spine apparatus	CHRFAM7A CHRNA7	1.69e-04	9	46	2	GO:0097444
GeneOntologyCellularComponent	acetylcholine-gated channel complex	CHRFAM7A CHRNA7	7.09e-04	18	46	2	GO:0005892
GeneOntologyCellularComponent	glycinergic synapse	CHRFAM7A CHRNA7	8.78e-04	20	46	2	GO:0098690
GeneOntologyCellularComponent	axolemma	CHRFAM7A CHRNA7	9.69e-04	21	46	2	GO:0030673
GeneOntologyCellularComponent	cholinergic synapse	CHRFAM7A CHRNA7	1.06e-03	22	46	2	GO:0098981
MousePheno	airway basal cell hyperplasia	CHRFAM7A CHRNA7	6.09e-06	2	35	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRFAM7A CHRNA7	6.09e-06	2	35	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRFAM7A CHRNA7	6.09e-06	2	35	2	MP:0011113
MousePheno	abnormal nicotine-mediated receptor currents	CHRFAM7A CHRNA7	3.64e-05	4	35	2	MP:0009475
MousePheno	failure of neuromuscular synapse presynaptic differentiation	CHRFAM7A CHRNA7	9.08e-05	6	35	2	MP:0001054
MousePheno	abnormal GABAergic neuron physiology	CHRFAM7A CHRNA7	1.69e-04	8	35	2	MP:0011987
MousePheno	impaired spatial working memory	CHRFAM7A CHRNA7	3.96e-04	12	35	2	MP:0014370
MousePheno	decreased erythroblast number	CHRFAM7A CHRNA7	3.96e-04	12	35	2	MP:0011179
Domain	NUT	NUTM2B NUTM2A	5.40e-05	5	44	2	IPR024310
Domain	NUT_N	NUTM2B NUTM2A	5.40e-05	5	44	2	IPR024309
Domain	NUT	NUTM2B NUTM2A	5.40e-05	5	44	2	PF12881
Domain	LRR_6	FBXL17 NLRP9 NOD1	2.94e-04	55	44	3	PF13516
Domain	Rap_GAP_dom	GARNL3 RALGAPB	2.94e-04	11	44	2	IPR000331
Domain	RAPGAP	GARNL3 RALGAPB	2.94e-04	11	44	2	PS50085
Domain	Calpain_III	CAPN1 CAPN3	3.53e-04	12	44	2	IPR022683
Domain	calpain_III	CAPN1 CAPN3	3.53e-04	12	44	2	SM00720
Domain	C2_III	CAPN1 CAPN3	3.53e-04	12	44	2	IPR033883
Domain	Calpain_domain_III	CAPN1 CAPN3	4.16e-04	13	44	2	IPR022682
Domain	Calpain_III	CAPN1 CAPN3	4.16e-04	13	44	2	PF01067
Domain	Calpain_cysteine_protease	CAPN1 CAPN3	4.85e-04	14	44	2	IPR022684
Domain	CysPc	CAPN1 CAPN3	5.59e-04	15	44	2	SM00230
Domain	CALPAIN_CAT	CAPN1 CAPN3	5.59e-04	15	44	2	PS50203
Domain	Peptidase_C2_calpain_cat	CAPN1 CAPN3	5.59e-04	15	44	2	IPR001300
Domain	Peptidase_C2	CAPN1 CAPN3	5.59e-04	15	44	2	PF00648
Domain	NACHT	NLRP9 NOD1	1.33e-03	23	44	2	PS50837
Domain	Acetylcholine_rcpt_TM	CHRFAM7A CHRNA7	1.33e-03	23	44	2	IPR027361
Domain	-	CHRFAM7A CHRNA7	1.33e-03	23	44	2	1.20.120.370
Domain	NACHT_NTPase	NLRP9 NOD1	1.33e-03	23	44	2	IPR007111
Domain	THIOL_PROTEASE_CYS	CAPN1 CAPN3	1.70e-03	26	44	2	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN1 CAPN3	1.83e-03	27	44	2	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN1 CAPN3	1.83e-03	27	44	2	PS00639
Domain	Pept_cys_AS	CAPN1 CAPN3	1.97e-03	28	44	2	IPR000169
Domain	EF-hand_8	CAPN1 CAPN3	2.90e-03	34	44	2	PF13833
Domain	Neurotransmitter_ion_chnl_CS	CHRFAM7A CHRNA7	5.04e-03	45	44	2	IPR018000
Domain	Neur_chan_memb	CHRFAM7A CHRNA7	5.26e-03	46	44	2	PF02932
Domain	Neur_chan_LBD	CHRFAM7A CHRNA7	5.48e-03	47	44	2	PF02931
Domain	Neur_channel	CHRFAM7A CHRNA7	5.48e-03	47	44	2	IPR006201
Domain	Neur_chan_lig-bd	CHRFAM7A CHRNA7	5.48e-03	47	44	2	IPR006202
Domain	NEUROTR_ION_CHANNEL	CHRFAM7A CHRNA7	5.48e-03	47	44	2	PS00236
Domain	Neurotrans-gated_channel_TM	CHRFAM7A CHRNA7	5.48e-03	47	44	2	IPR006029
Domain	-	CHRFAM7A CHRNA7	5.48e-03	47	44	2	2.70.170.10
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	38070724
Pubmed	Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19626424
Pubmed	Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17012698
Pubmed	Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	26451017
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	34453977
Pubmed	Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24757672
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	27129924
Pubmed	Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17291692
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19344760
Pubmed	Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	35926661
Pubmed	The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17640819
Pubmed	Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23431157
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	32552811
Pubmed	Involvement of calpains in Ca2+-induced disruption of excitation-contraction coupling in mammalian skeletal muscle fibers.	CAPN1 CAPN3	1.79e-06	2	47	2	19295178
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24836856
Pubmed	Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	31904546
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	35678315
Pubmed	Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33117372
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	12628457
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	25157794
Pubmed	Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19615981
Pubmed	Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	38944290
Pubmed	Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	28243714
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22246862
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24298024
Pubmed	Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	29975102
Pubmed	α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	29580318
Pubmed	Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	35479080
Pubmed	[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].	CHRFAM7A CHRNA7	1.79e-06	2	47	2	38597441
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22688057
Pubmed	α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22820264
Pubmed	Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33953172
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	32028688
Pubmed	Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	30089821
Pubmed	Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	20615555
Pubmed	Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15896732
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	21501254
Pubmed	mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans.	CAPN1 CAPN3	1.79e-06	2	47	2	16107503
Pubmed	α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	21339364
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	21368056
Pubmed	Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24289814
Pubmed	Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19949071
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	1400473
Pubmed	Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17204496
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	26937017
Pubmed	α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	37017608
Pubmed	Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23795917
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	36603528
Pubmed	Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	20592195
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	26650489
Pubmed	Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	11854451
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22848433
Pubmed	Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23842742
Pubmed	Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17292512
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	35413868
Pubmed	Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23637989
Pubmed	Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).	CHRFAM7A CHRNA7	1.79e-06	2	47	2	9782083
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22490926
Pubmed	Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	36997969
Pubmed	A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15364017
Pubmed	Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23769729
Pubmed	Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15944242
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	18077004
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19462340
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	11790782
Pubmed	A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33422641
Pubmed	Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	30270436
Pubmed	Activation of α-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	34988776
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	37746145
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19631623
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15770102
Pubmed	Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24326163
Pubmed	Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33398432
Pubmed	Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23811428
Pubmed	beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	20374280
Pubmed	Proteome profile of the cerebellum from α7 nicotinic acetylcholine receptor deficient mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	38185761
Pubmed	Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	20720594
Pubmed	α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22624500
Pubmed	Involvement of acetylcholine-α7nAChR in the protective effects of arterial baroreflex against ischemic stroke.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23106973
Pubmed	Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33902624
Pubmed	Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17019565
Pubmed	Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19100751
Pubmed	Identification of an alternatively processed nicotinic receptor alpha7 subunit RNA in mouse brain.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	14499477
Pubmed	Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15969741
Pubmed	Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	35883638
Cytoband	12q13.1	INHBC HDAC7	6.73e-05	12	47	2	12q13.1
Cytoband	10q22.3	NUTM2E NUTM2B	9.02e-04	43	47	2	10q22.3
GeneFamily	C2 domain containing\|Calpains	CAPN1 CAPN3	3.14e-04	15	32	2	975
GeneFamily	NLR family	NLRP9 NOD1	8.88e-04	25	32	2	666
CoexpressionAtlas	alpha beta T cells, T.8Mem.Sp, 4- 8+ 25- 44hi 122hi, Spleen, avg-3	TBXA2R PRKCH NOD1 UST HDAC7 INPP4B	3.14e-05	303	43	6	GSM538398_500
CoexpressionAtlas	gudmap_RNAseq_e11.5_Ureteric_bud_2500_K1	DOCK4 ABCA4 NOD1 HDAC7 INPP4B	6.11e-05	208	43	5	gudmap_RNAseq_e11.5_Ureteric_bud_2500_K1
CoexpressionAtlas	gamma delta T cells, Tgd.vg1+vd6-.Th.TCRbko, TCRd+ Vg1.1+, Thymus, avg-3	PRKCH HDAC7 FKBP5 DISP1 CAPN1 CDK4	8.43e-05	362	43	6	GSM605784_500
CoexpressionAtlas	gamma delta T cells, Tgd.vg2-.Sp, TCRd+ Vg2- CD44-, Spleen, avg-3	PRKCH HDAC7 FKBP5 DISP1 INPP4B CAPN1	1.13e-04	382	43	6	GSM476684_500
CoexpressionAtlas	gamma delta T cells, Tgd.vg2+.Sp.TCRbko, TCRd+ Vg2+ CD44-, Spleen, avg-3	PRKCH NOD1 HDAC7 DISP1 INPP4B CAPN1	1.23e-04	388	43	6	GSM605790_500
CoexpressionAtlas	gamma delta T cells, Tgd.vg2-.Sp.TCRbko, TCRd+ Vg2- CD44-, Spleen, avg-3	PRKCH NOD1 FKBP5 DISP1 INPP4B CAPN1	1.56e-04	405	43	6	GSM605796_500
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXA2R GRM8 CHRFAM7A CHRNA7 INPP4B	9.57e-07	173	46	5	af85fb9f6e26a044ca4d23e5872039b1a7b73b1b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXA2R SLCO5A1 CHRFAM7A CHRNA7 INPP4B	1.33e-06	185	46	5	027020754dbf71b0034791f9a34ae795e3b85f81
ToppCell	droplet-Thymus\|droplet / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXA2R PRKCH HDAC7 FKBP5 CAPN3	1.33e-06	185	46	5	83a78d17ad59503a694c1250082c4d8ae74d63e1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLCO5A1 SLFN11 CHRFAM7A CHRNA7 INPP4B	1.40e-06	187	46	5	02105c82a9ba79d2f19e002188377fc3440770c2
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Pax6\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ISOC1 NOD1 UST CHRNA7	9.88e-06	130	46	4	60e28d452d0e2af768459ba8dbe998117c94a251
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLCO5A1 VOPP1 CHRFAM7A FKBP5	2.52e-05	165	46	4	d8b0a9b6f704b98e8f0412c11739879a26c036e2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM8 CHRFAM7A CHRNA7 INPP4B	3.04e-05	173	46	4	0ba64e5385fe714f876002520f8b5202809bf11e
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLCO5A1 VOPP1 CHRFAM7A CHRNA7	3.32e-05	177	46	4	aa56129d2d5a73a10e33b7162233a4d9337ee535
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLCO5A1 VOPP1 CHRFAM7A CHRNA7	3.32e-05	177	46	4	d78a6003ce2d15d7771ae385de252eec7e3c3eea
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLCO5A1 VOPP1 CHRFAM7A CHRNA7	3.32e-05	177	46	4	70ca5b6fde2e38af1eb88a7d6e8746edba298191
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLCO5A1 CHRFAM7A CHRNA7 INPP4B	3.62e-05	181	46	4	2f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLCO5A1 CHRFAM7A CHRNA7 INPP4B	3.70e-05	182	46	4	7dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLCO5A1 CHRFAM7A CHRNA7 INPP4B	3.78e-05	183	46	4	e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLCO5A1 CHRFAM7A CHRNA7 INPP4B	3.78e-05	183	46	4	5e361be3ae3fe05098968e58427630127bd12675
ToppCell	facs-Thymus\|facs / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXA2R HDAC7 INPP4B CAPN3	3.86e-05	184	46	4	58beef66bbbde2479ec69dfef392d5941cedf230
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN MTHFR FKBP5 INPP4B	3.86e-05	184	46	4	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLCO5A1 CHRFAM7A CHRNA7 INPP4B	3.95e-05	185	46	4	16e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLCO5A1 CHRFAM7A CHRNA7 INPP4B	3.95e-05	185	46	4	487fa382232564f075960899d50afa0edae5d258
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLCO5A1 CHRFAM7A CHRNA7 INPP4B	3.95e-05	185	46	4	08fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLCO5A1 CHRFAM7A CHRNA7 INPP4B	4.03e-05	186	46	4	fef543f188edb0d1704d9c6ace366a0f8017bf53
ToppCell	HSPCs-Mk_prog.\|HSPCs / Lineage and Cell class	TBXA2R ABCA4 INPP4B CAPN3	4.75e-05	194	46	4	5c05d508f5c29e6efe87506bf59e3b0fe5922f65
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_TRM/EMRA\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRKCH TRBV28 FKBP5 INPP4B	5.14e-05	198	46	4	cf2057fc7c41d509ff76c0f1916e801a2a8406b2
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLCO5A1 CHRFAM7A CHRNA7 INPP4B	5.34e-05	200	46	4	53d5e427f0cbf5cf0b63efe4ec01da302f555704
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLCO5A1 SLFN11 CHRFAM7A CHRNA7	5.34e-05	200	46	4	c1797542541747b524c9c22c723d24c8d027d486
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLCO5A1 CHRFAM7A CHRNA7 INPP4B	5.34e-05	200	46	4	d0167f96314be78b6d867bbcc6e4396071d931b8
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLCO5A1 SLFN11 CHRFAM7A CHRNA7	5.34e-05	200	46	4	a0cc84add181109bb66ba9d49c732e1790222c96
Drug	AC1L1ET5	PRKCH INPP4B CAPN1 CAPN3	7.54e-06	65	44	4	CID000002936
Drug	m(7)GpppG	ESCO2 PRKCH CHRFAM7A ITIH2 CHRNA7	8.12e-06	143	44	5	CID000121958
Drug	tetracaine	PRKCH CHRFAM7A ADCY7 CHRNA7	2.51e-05	88	44	4	CID000005411
Drug	Hydrastinine hydrochloride [4884-68-8]; Up 200; 16.4uM; MCF7; HT_HG-U133A	TBXA2R HIC2 GRM8 UST HDAC7	3.45e-05	193	44	5	2283_UP
Drug	Adamantamine fumarate [80789-67-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	NOD1 HDAC7 MTHFR FKBP5 ITIH2	3.71e-05	196	44	5	4806_UP
Drug	troglitazone; Up 200; 10uM; SKMEL5; HG-U133A	DCAF1 TBXA2R NOD1 ITIH2 RALGAPB	3.81e-05	197	44	5	504_UP
Drug	Serotonin hydrochloride [153-98-0]; Up 200; 18.8uM; MCF7; HT_HG-U133A	TBXA2R GRM8 INHBC HDAC7 MTHFR	3.81e-05	197	44	5	3311_UP
Drug	Canrenoic acid potassium salt [2181-04-6]; Up 200; 10uM; MCF7; HT_HG-U133A	TBXA2R DOCK4 HIC2 MTHFR ITIH2	3.90e-05	198	44	5	2228_UP
Drug	rose bengal	ESCO2 TBXA2R KCNK17	4.60e-05	36	44	3	CID000025473
Drug	GF109203X	TBXA2R PRKCH ARR3 GRM8 ADCY7 CDK4	4.72e-05	341	44	6	CID000002396
Drug	norethisterone oenanthate	CHRFAM7A MTHFR ITIH2 CHRNA7	5.82e-05	109	44	4	CID000019688
Drug	methacholine	TBXA2R PRKCH NOD1 CHRFAM7A CHRNA7	6.03e-05	217	44	5	CID000001993
Drug	serotonin	TBXA2R PRKCH CHRFAM7A ADCY7 FKBP5 CHRNA7 CAPN3	8.53e-05	554	44	7	CID000005202
Drug	glibenclamide	TBXA2R PRKCH ABCA4 MTHFR ADCY7 CAPN3	8.83e-05	382	44	6	CID000003488
Drug	AC1L1KAK	ABCA4 INHBC CAPN3	9.65e-05	46	44	3	CID000005409
Drug	indeloxazine	KCNK17 CAPN3	1.01e-04	8	44	2	CID000003704
Drug	Moldin	CHRFAM7A MTHFR CHRNA7	1.24e-04	50	44	3	CID000026331
Drug	G-G-G	CHRFAM7A MTHFR CHRNA7	1.24e-04	50	44	3	CID000448212
Drug	SQ22536	TBXA2R PRKCH ADCY7 CDK4	1.34e-04	135	44	4	CID000005270
Drug	myo-inositol	TBXA2R PRKCH ARR3 GRM8 CHRFAM7A ADCY7 CHRNA7 INPP4B	1.42e-04	811	44	8	CID000000892
Drug	muscarine	PRKCH CHRFAM7A ADCY7 CHRNA7	1.71e-04	144	44	4	CID000009308
Drug	isoflurane	PRKCH KCNK17 GRM8 CHRFAM7A CHRNA7	1.96e-04	279	44	5	CID000003763
Drug	Dns-C6-Cho	CHRFAM7A CHRNA7	1.99e-04	11	44	2	CID000124728
Drug	AC1L9NC9	CHRFAM7A CHRNA7	1.99e-04	11	44	2	CID000449642
Drug	dihydronereistoxin	CHRFAM7A CHRNA7	1.99e-04	11	44	2	CID000121232
Drug	Dihydro-beta-Erythroidine	CHRNA7 CDK4	1.99e-04	11	44	2	ctd:D004079
Drug	bipinnatin-B	CHRFAM7A CHRNA7	1.99e-04	11	44	2	CID000127363
Drug	LJP 1082	CHRFAM7A CHRNA7	1.99e-04	11	44	2	CID003037609
Drug	H-8105	TBXA2R PRKCH CHRFAM7A ADCY7 CHRNA7	2.06e-04	282	44	5	CID000164531
Drug	oriens	GRM8 CHRFAM7A CHRNA7 CAPN1	2.21e-04	154	44	4	CID000161645
Drug	otenzepad	CHRFAM7A ADCY7 CHRNA7	2.24e-04	61	44	3	CID000107867
Drug	AC1L9P8C	CHRFAM7A CHRNA7	2.38e-04	12	44	2	CID000450864
Drug	SureCN373116	CHRFAM7A CHRNA7	2.38e-04	12	44	2	CID010085732
Drug	nereistoxin	CHRFAM7A CHRNA7	2.81e-04	13	44	2	CID000015401
Drug	1-acetyl-4-methylpiperazine methiodide	CHRFAM7A CHRNA7	2.81e-04	13	44	2	CID004392675
Drug	C-toxiferine-I	CHRFAM7A CHRNA7	2.81e-04	13	44	2	CID005089093
Drug	bipinnatin-C	CHRFAM7A CHRNA7	2.81e-04	13	44	2	CID000129977
Drug	bipinnatin-A	CHRFAM7A CHRNA7	2.81e-04	13	44	2	CID000196603
Drug	benzilate	CHRFAM7A ADCY7 CHRNA7	2.83e-04	66	44	3	CID000201538
Drug	AC1NSKJI	CHRFAM7A ADCY7 CHRNA7	3.09e-04	68	44	3	CID005311391
Drug	paramethoxyphenyl-acetyl dehydroalanine	CHRFAM7A MTHFR CHRNA7	3.23e-04	69	44	3	CID000130300
Drug	carbachol	TBXA2R PRKCH NOD1 GRM8 CHRFAM7A ADCY7 CHRNA7	3.23e-04	688	44	7	CID000002551
Drug	2,3-dichlorooctafluorobutane	CHRFAM7A CHRNA7	3.27e-04	14	44	2	CID000078982
Drug	LNF 209	CHRFAM7A CHRNA7	3.27e-04	14	44	2	CID000132666
Drug	halothane	PRKCH KCNK17 CHRFAM7A ADCY7 CHRNA7	3.38e-04	314	44	5	CID000003562
Drug	verapamil	PRKCH ABCA4 KCNK17 CHRFAM7A ADCY7 CHRNA7	3.40e-04	490	44	6	CID000002520
Drug	methoxamine	TBXA2R PRKCH ADCY7	3.51e-04	71	44	3	CID000006081
Drug	Cortisporin	PRKCH CHRFAM7A CHRNA7 CAPN3	3.76e-04	177	44	4	CID000004454
Drug	aa373	CHRFAM7A CHRNA7	3.77e-04	15	44	2	CID000191672
Drug	BMY 42393	TBXA2R ADCY7	3.77e-04	15	44	2	CID000131961
Drug	anatoxin-a hydrochloride	CHRFAM7A CHRNA7	3.77e-04	15	44	2	CID000135265
Drug	(-)-pictamine	CHRFAM7A CHRNA7	3.77e-04	15	44	2	CID006918623
Drug	(-)-lepadin B	CHRFAM7A CHRNA7	3.77e-04	15	44	2	CID006918624
Drug	SAD-128	CHRFAM7A CHRNA7	3.77e-04	15	44	2	CID000162008
Drug	UB-165	CHRFAM7A CHRNA7	3.77e-04	15	44	2	CID004694339
Drug	N-methylcytisine	CHRFAM7A CHRNA7	3.77e-04	15	44	2	CID000234566
Drug	3-(trifluoromethyl)-3-(m-iodophenyl)diazirine	CHRFAM7A CHRNA7	4.31e-04	16	44	2	CID000123866
Drug	AC1L2SVN	CHRFAM7A CHRNA7	4.31e-04	16	44	2	CID000127922
Drug	benzoquinonium	CHRFAM7A CHRNA7	4.31e-04	16	44	2	CID000009393
Drug	PNU-282,987	CHRFAM7A CHRNA7	4.31e-04	16	44	2	CID004655349
Drug	Halcinonide [3093-35-4]; Up 200; 8.8uM; HL60; HT_HG-U133A	TBXA2R HIC2 ARR3 FKBP5	4.35e-04	184	44	4	2185_UP
Drug	oxymetazoline	CHRFAM7A ADCY7 CHRNA7	4.81e-04	79	44	3	CID000004636
Drug	Nsc36388	CHRFAM7A CHRNA7	4.87e-04	17	44	2	CID000014954
Drug	Danazol [17230-88-5]; Down 200; 11.8uM; HL60; HG-U133A	TBXA2R HIC2 ERO1A CAPN1	5.01e-04	191	44	4	2038_DN
Drug	ICI 182,780; Up 200; 1uM; PC3; HT_HG-U133A	OR2B2 GRM8 UST ITIH2	5.11e-04	192	44	4	4429_UP
Drug	N6-methyladenosine [1867-73-8]; Up 200; 14.2uM; PC3; HT_HG-U133A	TBXA2R ARR3 NOD1 MTHFR	5.21e-04	193	44	4	6732_UP
Drug	Pyridoxine hydrochloride [58-56-0]; Up 200; 19.4uM; HL60; HG-U133A	TBXA2R DOCK4 INHBC ERO1A	5.31e-04	194	44	4	1759_UP
Drug	Cyclizine hydrochloride [303-25-3]; Up 200; 13.2uM; MCF7; HT_HG-U133A	DCAF1 ARR3 MTHFR ITIH2	5.31e-04	194	44	4	5525_UP
Drug	Flucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A	TBXA2R NOD1 GRM8 INHBC	5.31e-04	194	44	4	6507_UP
Drug	Enilconazole [35554-44-0]; Up 200; 13.4uM; PC3; HT_HG-U133A	TBXA2R HIC2 MTHFR ITIH2	5.42e-04	195	44	4	5113_UP
Drug	Molindone hydrochloride [15622-65-8]; Down 200; 12.8uM; PC3; HT_HG-U133A	TBXA2R GRM8 MTHFR FKBP5	5.42e-04	195	44	4	4199_DN
Drug	Pilocarpine nitrate [148-72-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A	DOCK4 GRM8 HDAC7 ERO1A	5.42e-04	195	44	4	3300_UP
Drug	AC1O8PVM	CHRFAM7A CHRNA7	5.48e-04	18	44	2	CID000004989
Drug	benzetimide	CHRFAM7A CHRNA7	5.48e-04	18	44	2	CID000021846
Drug	ABT-594	CHRFAM7A CHRNA7	5.48e-04	18	44	2	CID003075702
Drug	AC1LCVGE	CHRFAM7A CHRNA7	5.48e-04	18	44	2	CID000656712
Drug	Mianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; MCF7; HT_HG-U133A	DCAF1 HIC2 NOD1 MTHFR	5.52e-04	196	44	4	6260_UP
Drug	2-propylpentanoic acid; Up 200; 200uM; HL60; HT_HG-U133A	DOCK4 UST MTHFR INPP4B	5.52e-04	196	44	4	1155_UP
Drug	Benzocaine [94-09-7]; Up 200; 24.2uM; MCF7; HT_HG-U133A	TBXA2R PRKCH NOD1 HDAC7	5.52e-04	196	44	4	4808_UP
Drug	Betulinic acid [472-15-1]; Down 200; 8.8uM; PC3; HT_HG-U133A	HIC2 ARR3 NOD1 FKBP5	5.52e-04	196	44	4	4101_DN
Drug	Hymecromone [90-33-5]; Up 200; 22.8uM; PC3; HT_HG-U133A	TBXA2R HIC2 ARR3 GRM8	5.52e-04	196	44	4	4623_UP
Drug	Cefamandole sodium salt [30034-03-8]; Up 200; 8.2uM; MCF7; HT_HG-U133A	TBXA2R OR2B2 MTHFR ITIH2	5.52e-04	196	44	4	4718_UP
Drug	estradiol, USP; Down 200; 0.01uM; PC3; HT_HG-U133A	TBXA2R HDAC7 FKBP5 ITIH2	5.52e-04	196	44	4	4465_DN
Drug	Azathymine, 6 [932-53-6]; Up 200; 31.4uM; MCF7; HT_HG-U133A	TBXA2R GRM8 INHBC MTHFR	5.52e-04	196	44	4	4106_UP
Drug	Lumicolchicine gamma [6901-14-0]; Down 200; 10uM; PC3; HT_HG-U133A	TBXA2R GRM8 MTHFR FKBP5	5.52e-04	196	44	4	4195_DN
Drug	Melitten	TBXA2R CHRNA7 CDK4	5.55e-04	83	44	3	ctd:D008555
Drug	Ino-Hcy	GRM8 CHRFAM7A CHRNA7	5.55e-04	83	44	3	CID000193585
Drug	Josamycin [16846-24-5]; Up 200; 4.8uM; PC3; HT_HG-U133A	ARR3 UST MTHFR ITIH2	5.63e-04	197	44	4	4631_UP
Drug	Methylhydantoin-5-(L) [40856-73-3]; Up 200; 35uM; PC3; HT_HG-U133A	TBXA2R GRM8 MTHFR FKBP5	5.63e-04	197	44	4	4618_UP
Drug	Ioversol [87771-40-2]; Up 200; 5uM; PC3; HT_HG-U133A	TBXA2R HIC2 INHBC MTHFR	5.63e-04	197	44	4	6726_UP
Drug	Cefotiam hydrochloride; Up 200; 7.2uM; MCF7; HT_HG-U133A	DCAF1 ARR3 GRM8 INHBC	5.63e-04	197	44	4	3319_UP
Drug	Bupivacaine hydrochloride [18010-40-7]; Up 200; 12.4uM; MCF7; HT_HG-U133A	TBXA2R PRKCH FKBP5 ITIH2	5.63e-04	197	44	4	5537_UP
Drug	Seneciphylline [480-81-9]; Up 200; 12uM; PC3; HT_HG-U133A	DCAF1 TBXA2R INHBC CAPN3	5.63e-04	197	44	4	4238_UP
Drug	Bethanechol chloride [590-63-6]; Up 200; 20.4uM; PC3; HT_HG-U133A	HIC2 UST HDAC7 MTHFR	5.74e-04	198	44	4	5114_UP
Drug	Beta-sistosterol [83-46-5]; Up 200; 9.6uM; MCF7; HT_HG-U133A	DCAF1 PRKCH NOD1 GRM8	5.74e-04	198	44	4	7332_UP
Drug	Telenzepine dihydrochloride [147416-96-4]; Up 200; 9uM; PC3; HT_HG-U133A	HIC2 GRM8 HDAC7 CAPN3	5.74e-04	198	44	4	5096_UP
Drug	Alverine citrate salt [5560-59-8]; Up 200; 8.4uM; MCF7; HT_HG-U133A	TBXA2R GRM8 HDAC7 MTHFR	5.74e-04	198	44	4	2273_UP
Drug	Tyloxapol [25301-02-4]; Up 200; 4uM; MCF7; HT_HG-U133A	TBXA2R OR2B2 GRM8 ITIH2	5.74e-04	198	44	4	5672_UP
Drug	H-7 dihydrochloride; Up 200; 100uM; PC3; HT_HG-U133A	DCAF1 TBXA2R GRM8 ITIH2	5.85e-04	199	44	4	5968_UP
Drug	Cyproheptadine hydrochloride [969-33-5]; Up 200; 12.4uM; MCF7; HT_HG-U133A	DOCK4 HIC2 NOD1 ADCY7	5.85e-04	199	44	4	1521_UP
Disease	hereditary spastic paraplegia 76 (implicated_via_orthology)	CAPN1 CAPN3	2.17e-05	5	44	2	DOID:0110821 (implicated_via_orthology)
Disease	Endometrial Stromal Sarcoma	NUTM2B NUTM2A	2.17e-05	5	44	2	C0206630
Disease	cognitive disorder (implicated_via_orthology)	CHRFAM7A CHRNA7	3.25e-05	6	44	2	DOID:1561 (implicated_via_orthology)
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	3.25e-05	6	44	2	C0334488
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRFAM7A CHRNA7	3.25e-05	6	44	2	DOID:7148 (biomarker_via_orthology)
Disease	Stargardt's disease	ABCA4 ITIH2	3.25e-05	6	44	2	C0271093
Disease	Pulmonary Thromboembolisms	TBXA2R MTHFR	1.42e-04	12	44	2	C0524702
Disease	Pulmonary Embolism	TBXA2R MTHFR	1.42e-04	12	44	2	C0034065
Disease	nicotine dependence (implicated_via_orthology)	CHRFAM7A CHRNA7	1.42e-04	12	44	2	DOID:0050742 (implicated_via_orthology)
Disease	Neurobehavioral Manifestations	FKBP5 CHRNA7	1.42e-04	12	44	2	C0525041
Disease	schizophrenia (is_implicated_in)	GRM8 MTHFR CHRNA7	2.18e-04	78	44	3	DOID:5419 (is_implicated_in)
Disease	post-traumatic stress disorder	DOCK4 FBXL17 OR2B2 UST	2.34e-04	202	44	4	EFO_0001358
Disease	response to methotrexate	UST INPP4B	2.57e-04	16	44	2	GO_0031427
Disease	attention deficit hyperactivity disorder (is_implicated_in)	GRM8 MTHFR	4.06e-04	20	44	2	DOID:1094 (is_implicated_in)
Disease	Autistic Disorder	DOCK4 GRM8 MTHFR CHRNA7	6.15e-04	261	44	4	C0004352
Disease	Alcoholic Intoxication, Chronic	GRM8 MTHFR ADCY7 FKBP5	6.79e-04	268	44	4	C0001973
Disease	cerebral infarction (is_implicated_in)	PRKCH MTHFR	8.60e-04	29	44	2	DOID:3526 (is_implicated_in)
Disease	Acute Myeloid Leukemia, M1	VOPP1 ADCY7 INPP4B	8.66e-04	125	44	3	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	VOPP1 ADCY7 INPP4B	8.66e-04	125	44	3	C1879321
Disease	mood instability measurement	FBXL17 SLC15A5 GRM8	9.27e-04	128	44	3	EFO_0008475
Disease	uridine measurement	ABCA4 NALCN	1.05e-03	32	44	2	EFO_0010546
Disease	diabetic retinopathy	GRM8 UST INPP4B	1.10e-03	136	44	3	EFO_0003770
Disease	glycine measurement	GRM8 MTHFR CAPN3	1.13e-03	137	44	3	EFO_0009767
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN1 CAPN3	1.33e-03	36	44	2	DOID:11723 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MGIRLLCRVAFCFLA	TRBV28	1	A0A5B6
CFVDDSFMIILNRCF	ABCA4	641	P78363
CVLGFIACSVFLRMS	ADCY7	726	P51828
VCCLVRLETMFRFFK	CAPN1	676	P07384
AFATFFFQCMCRCLG	DISP1	1121	Q96F81
CRKLFVMLTCAFRYG	ARR3	46	P36575
KFAACVVDRLCLMAF	CHRNA7	461	P36544
HRCVLAACSDFFRAM	KBTBD3	66	Q8NAB2
CGGRMFDCRDVAFTV	FKBP5	176	Q13451
FTCCAFSARERFLML	DCAF1	1096	Q9Y4B6
FFRFVKACTDMGITC	MTHFR	236	P42898
MACDRFVAICFPLRY	OR10D4P	116	Q8NGN7
VFFCCDMQERFRPAI	ISOC1	116	Q96CN7
MKRLTCFFICFFLSE	ITIH2	1	P19823
MCCRQEFFVDFREIG	INHBC	246	P55103
FFIRALDCMRREGCR	INPP4B	871	O15327
TMAARLFCIFFALVG	KCNK17	126	Q96T54
FFHFRCRMFSCFKES	NOD1	231	Q9Y239
IICSFRRVFLGLGMC	GRM8	646	O00222
KFAACVVDRLCLMAF	CHRFAM7A	371	Q494W8
KVTRMCFAVFLCFAL	GPR84	316	Q9NQS5
FRCCIQELLMSVRFF	DOCK4	731	Q8N1I0
GCIFAEMFRRKPLFC	CDK4	201	P11802
RDCFFRGPCMLCFIV	FBXL17	51	Q9UF56
HFRNISRIMDCVGCF	ERO1A	381	Q96HE7
RRLVDTLRNCFMFGC	ESCO2	551	Q56NI9
AMGFCFFNSVAIACR	HDAC7	676	Q8WUI4
SFICCFVRLEGMFRA	CAPN3	781	P20807
LCERFTFFEVVCNMI	SLC15A5	51	A6NIM6
MVVDFCRRFVARSLC	GARNL3	1	Q5VVW2
AVMCFDRFVAICRPL	OR2B2	116	Q9GZK3
CRMSGVLCSRNLFTF	NUTM2A	66	Q8IVF1
CRMSGVLCSRNLFTF	NUTM2B	66	A6NNL0
CRMSGVLCSRNLFTF	NUTM2E	66	B1AL46
FACDECGMRFTRQYR	HIC2	561	Q96JB3
LEMNGRHRFCFLRCC	RTF2	126	Q9BY42
DSRCFLVCMCFLTFI	SLCO5A1	126	Q9H2Y9
EQIMTCVADTCRRFF	SLFN11	786	Q7Z7L1
GIMFSTFEFCKRICL	SLC25A43	281	Q8WUT9
RRGDCFAFMHLCIQE	NLRP9	436	Q7RTR0
RDYGFCMATLLVFCL	UST	46	Q9Y2C2
VLFCCGAGFFIRRRM	VOPP1	71	Q96AW1
FRAMRGISCLVDAFL	RALGAPB	336	Q86X10
FRCEERCAAFPMASS	ZNF544	326	Q6NX49
GCRLCRFMGVVMIFF	TBXA2R	101	P21731
CCFQTPDRLFFVMEF	PRKCH	421	P24723
MMGACVIVFRFFSIC	NALCN	1301	Q8IZF0