Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessbranching involved in lymph vessel morphogenesis

NFATC1 PKD1

8.88e-063362GO:0060854
GeneOntologyBiologicalProcessanimal organ morphogenesis

LAMC2 PRKCI ACP4 PAX1 LTBP3 CSMD1 NFATC1 FOXN4 PITX3 PKD1

4.37e-0512693610GO:0009887
GeneOntologyBiologicalProcessregulation of Toll signaling pathway

PELI1 PELI3

4.42e-056362GO:0008592
GeneOntologyCellularComponentGolgi membrane

CFP PRKCI B3GNT9 ZDHHC8 SLC30A10 NOTCH4 PKD1

1.63e-04721357GO:0000139
DomainGrowth_fac_rcpt_

LAMC2 ERBB2 LTBP3 MEGF6 NOTCH4

1.01e-05156355IPR009030
DomainPellino

PELI1 PELI3

1.02e-053352PF04710
DomainPellino_fam

PELI1 PELI3

1.02e-053352IPR006800
DomainhEGF

LTBP3 MEGF6 NOTCH4

1.91e-0528353PF12661
DomainZF_DAG_PE_1

RASGRP4 AKAP13 PRKCI

2.32e-0464353PS00479
DomainZF_DAG_PE_2

RASGRP4 AKAP13 PRKCI

2.32e-0464353PS50081
DomainC1

RASGRP4 AKAP13 PRKCI

2.43e-0465353SM00109
DomainPE/DAG-bd

RASGRP4 AKAP13 PRKCI

2.54e-0466353IPR002219
DomainEGF_CA

LTBP3 MEGF6 NOTCH4

5.55e-0486353PF07645
DomainDAG/PE-bd

RASGRP4 PRKCI

7.01e-0421352IPR020454
DomainEGF_Ca-bd_CS

LTBP3 MEGF6 NOTCH4

7.88e-0497353IPR018097
DomainEGF_CA

LTBP3 MEGF6 NOTCH4

8.36e-0499353PS01187
DomainASX_HYDROXYL

LTBP3 MEGF6 NOTCH4

8.61e-04100353PS00010
DomainEGF

LAMC2 LTBP3 MEGF6 NOTCH4

9.42e-04235354SM00181
DomainEGF-type_Asp/Asn_hydroxyl_site

LTBP3 MEGF6 NOTCH4

1.02e-03106353IPR000152
DomainEGF-like_dom

LAMC2 LTBP3 MEGF6 NOTCH4

1.17e-03249354IPR000742
DomainEGF_1

LAMC2 LTBP3 MEGF6 NOTCH4

1.27e-03255354PS00022
DomainEGF-like_CS

LAMC2 LTBP3 MEGF6 NOTCH4

1.39e-03261354IPR013032
DomainEGF_2

LAMC2 LTBP3 MEGF6 NOTCH4

1.47e-03265354PS01186
DomainEGF_CA

LTBP3 MEGF6 NOTCH4

1.53e-03122353SM00179
DomainEGF-like_Ca-bd_dom

LTBP3 MEGF6 NOTCH4

1.60e-03124353IPR001881
DomainLaminin_EGF

LAMC2 MEGF6

1.95e-0335352PF00053
DomainEGF_Lam

LAMC2 MEGF6

1.95e-0335352SM00180
DomainLaminin_EGF

LAMC2 MEGF6

2.30e-0338352IPR002049
DomainC1_1

RASGRP4 PRKCI

5.10e-0357352PF00130
DomainEGF_3

LTBP3 MEGF6 NOTCH4

9.57e-03235353PS50026
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

PRKCI NOTCH4

7.94e-057282MM14734
Pubmed

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.

AKAP13 CSMD1 NOTCH4

4.59e-071536323583980
Pubmed

Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment.

NFATC1 TNFRSF4

1.04e-06236216501042
Pubmed

Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis.

ERBB2 NFATC1 NOTCH4

1.34e-062136322932696
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PER1 AKAP13 ERBB2 LTBP3 ZNF324B MEGF6 NFATC1 ZDHHC8 PKD1

1.39e-06110536935748872
Pubmed

[Replicative association analysis of genetic markers of cognitive traits with Alzheimer's disease in a Russian population].

CSMD1 NOTCH4

3.12e-06336225845235
Pubmed

Effects of OX40-OX40L interaction on the nuclear factor of activated T cells c1 in ApoE-deficient mice.

NFATC1 TNFRSF4

3.12e-06336224045961
Pubmed

Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice.

ERBB2 TNFRSF4

3.12e-06336215856473
Pubmed

Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway.

NFATC1 PKD1

3.12e-06336215466861
Pubmed

[Effect of the costimulatory molecules OX40-OX40 ligand interaction on the expression of NFATc1 in leukocytes of apolipoprotein E-deficient mice].

NFATC1 TNFRSF4

3.12e-06336221924079
Pubmed

Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins.

PELI1 PELI3

3.12e-06336227302665
Pubmed

OX40-OX40L interaction promotes proliferation and activation of lymphocytes via NFATc1 in ApoE-deficient mice.

NFATC1 TNFRSF4

6.24e-06436223593329
Pubmed

Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases.

PELI1 PELI3

6.24e-06436216884718
Pubmed

Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1.

PELI1 PELI3

6.24e-06436219081057
Pubmed

NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo.

PRKCI TNFRSF4

6.24e-06436220808283
Pubmed

Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.

PELI1 PELI3

1.56e-05636217675297
Pubmed

The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.

PELI1 PELI3

1.56e-05636225027698
Pubmed

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis.

PRKCI PKD1

2.18e-05736224153433
Pubmed

Suppression of bone formation by osteoclastic expression of semaphorin 4D.

ERBB2 NFATC1

2.18e-05736222019888
Pubmed

Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner.

PELI1 PELI3

2.91e-05836215917247
Pubmed

Evolutionary and molecular facts link the WWC protein family to Hippo signaling.

PRKCI WWC3

2.91e-05836224682284
Pubmed

Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification.

ERBB2 NFATC1

3.73e-05936229422515
Pubmed

Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression.

NFATC1 PKD1

5.70e-051136220375015
Pubmed

Endocardial Hippo signaling regulates myocardial growth and cardiogenesis.

ERBB2 NFATC1

5.70e-051136229727635
Pubmed

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.

LAMC2 PRKCI LTBP3 PKD1

6.54e-0521036416537572
Pubmed

Assignment of two alpha 2 adrenoceptor subtype genes to murine chromosomes.

PAX1 ADRA2C

6.83e-05123628177505
Pubmed

Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.

ERBB2 PKD1

9.41e-051436216400024
Pubmed

Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression.

ERBB2 NOTCH4

9.41e-051436221402699
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

PELI1 PRKCI ERBB2 B3GNT9 KMT2E PELI3

9.54e-0573036634857952
Pubmed

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.

DACT2 SLC30A10

1.40e-041736223754948
Pubmed

Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation.

PRKCI NFATC1

1.96e-042036226876178
Pubmed

Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.

LAMC2 NOTCH4

2.16e-042136221408207
Pubmed

Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.

ERBB2 ADRA2C

2.16e-04213621676978
Pubmed

Loss of Gata5 in mice leads to bicuspid aortic valve.

ERBB2 NOTCH4

2.83e-042436221633169
Pubmed

Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.

NOTCH4 TNFRSF4

2.83e-042436211739537
Pubmed

A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.

LAMC2 PRKCI

3.87e-042836225912685
Pubmed

Cdc42-mediated tubulogenesis controls cell specification.

PRKCI NOTCH4

3.87e-042836219914171
Pubmed

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.

PAX1 NOTCH4

4.16e-042936225535917
Pubmed

Specification of dopaminergic subsets involves interplay of En1 and Pitx3.

LTBP3 PITX3

4.75e-043136223863478
Pubmed

Discovery and validation of genes driving drug-intake and related behavioral traits in mice.

HDAC10 PITX3

5.39e-043336238164795
Pubmed

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.

ERBB2 NFATC1

7.15e-043836229743679
Pubmed

Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.

PRKCI NFATC1

7.15e-043836212482669
Pubmed

Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.

ERBB2 NFATC1

7.15e-043836218267097
Pubmed

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

LAMC2 CSMD1

7.54e-043936221347282
Pubmed

Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.

PRKCI ZDHHC8

8.33e-044136225452572
GeneFamilyPellino E3 ubiquitin protein ligases

PELI1 PELI3

7.45e-063292676
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

AKAP13 ERBB2

3.02e-0351292870
ToppCelldroplet-Fat-Bat-18m|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA2C CSMD1 MEGF6 ZDHHC8

1.05e-05170364c720d81bc29a8fd1f1249c6af408471d561f1d5d
ToppCelldroplet-Fat-Bat|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA2C CSMD1 MEGF6 ZDHHC8

1.05e-05170364c4ecdfc2b4710da0a5fbb20e9df02536023badb1
ToppCellMild-CD4+_T_Exhausted|Mild / Disease group and Cell class

PELI1 RASGRP4 CFP TNFRSF4

1.18e-051753646df099f37875f2cd63502b732a2e07ebfec50e47
ToppCell(2)_NK/T-(230)_CD4+/CD25+_Reg_T_cell|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)

PELI1 RASGRP4 MEGF6 TNFRSF4

1.35e-05181364ad14c7111d4fb924afd233cb114447f195373a7c
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

RASGRP4 LTBP3 MEGF6 NOTCH4

1.57e-05188364c90669b51e1902fe7726555290c91c92a911df83
ToppCellwk_08-11-Hematologic_Lymphocytic-T_&_ILC-ILC2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RASGRP4 CFP CRIP1 TNFRSF4

1.60e-051893649c963f525ae765499b3e3229fead3aef018345ef
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

DACT2 LAMC2 ADRA2C

1.27e-0412136305c40fd39e6b6275f35aaad835f95a81fcbb0990
ToppCellGlobus_pallidus|World / BrainAtlas - Mouse McCarroll V32

LTBP3 MEGF6 PKD1

1.43e-0412636344b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell21-Trachea-Immune-Immune|Trachea / Age, Tissue, Lineage and Cell class

PAX1 ZNF324B PELI3

1.72e-041343634f0465324cc5b443ebadb68aef63be79b74f6ff9
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PELI1 AKAP13 KMT2E

1.75e-04135363b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

DACT2 ACP4 CSMD1

2.35e-041493636e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCellLPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMC2 RASGRP4 CFP

2.63e-041553634559e3011514041b65c17ae4ede29da202bce14c
ToppCellPND10-Immune-Immune_Myeloid-DC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASGRP4 CFP CRIP1

2.73e-04157363ed387cf06d19e201a2a0dc4f3c796fcf8fa6637a
ToppCellwk_20-22-Epithelial-Proximal_epithelial-SMG_basal_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DACT2 PAX1 PELI3

2.79e-04158363adad97e6cf479d42791c5ba9cbc5f15f469322bf
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB2 CSMD1 SLC30A10

2.84e-04159363e967b557fe6ae4879d36f62c0297cbf6a2ad1ce9
ToppCellPosterior_cortex|World / BrainAtlas - Mouse McCarroll V32

PER1 LAMC2 KMT2E

2.84e-0415936318e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCellBronchial_Brush-Epithelial-Goblet_1|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

FEZF1 ZDHHC8 TNFRSF4

2.84e-04159363a8fa49dc2e6ad726d1f4f2b30693fecd1151a485
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB2 CSMD1 SLC30A10

2.84e-041593639db971130509c62d439e0cab16588a4d994d7aa0
ToppCellBronchial_Brush-Epithelial-Goblet_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

FEZF1 ZDHHC8 TNFRSF4

2.84e-0415936395834b767cfb4fb8c5aeea89c10f3e14a1fd15c1
ToppCellVE-CD8-naive_CD4|VE / Condition, Cell_class and T cell subcluster

PRKCI MEGF6 PELI3

2.89e-04160363255d2a150bfe19ee3d4d34533feb9c37ce73d225
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Spindle_Cell-1|TCGA-Uvea / Sample_Type by Project: Shred V9

LTBP3 ZDHHC8 PELI3

3.34e-04168363b427746929bb40e3d1b5f1c40d302b792d6b32a5
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

ADRA2C CSMD1 NOTCH4

3.34e-041683638c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASGRP4 NOTCH4 PELI3

3.45e-0417036355fe16d98ea284d05fb899888e4569c685644c7b
ToppCellPND14-Immune-Immune_Myeloid-DC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFP CRIP1 TNFRSF4

3.51e-041713638772d6349db24de47f089df2032a80345db7177f
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DACT2 CFP B3GNT9

3.63e-04173363c63a615998d13b1725b5767f4ad2ec7e2b61db68
ToppCellControl-CD4+_T_activated|Control / Disease group and Cell class

CFP NFATC1 PELI3

3.70e-041743632b683e81b315ad22555314433aed5681feb48da8
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Neutrophil|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RASGRP4 CFP ZXDB

3.82e-04176363676839d07450b313222622e0ffd305c732cbad6d
ToppCellPND07-Immune|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AKAP13 CFP CRIP1

3.82e-041763632f87f49b64c6f89823d540172a8e923ebaa6d6cd
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PER1 AKAP13 CFP

3.82e-04176363a31d7532f8c055d4e62bbaa78d819f2495bfee00
ToppCelldroplet-Lung-1m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RASGRP4 CFP CRIP1

3.82e-041763638f9d2a763b79cafe26dcbf3dba980d473a0b9873
ToppCelldroplet-Lung-1m-Hematologic-myeloid-classical_monocyte|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RASGRP4 CFP CRIP1

3.82e-041763633b5d12d5c22e32fbe80c3716ff14a7ae5769c165
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Activated_DCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

CFP CRIP1 PITX3

3.88e-04177363370aee11a6dc2c6f4366a13c3171f37bc5b32d65
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

MEGF6 NOTCH4 ZXDB

3.88e-04177363eb0cfe8e9a91910f9979608ed47add48d98ce4dd
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MEGF6 NOTCH4 ZXDB

3.95e-041783639d575902d3dbe33437c9d4200df093a741269803
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

B3GNT9 MEGF6 CRIP1

3.95e-04178363a107dd98a07086ed0429116095ecda60c9dbef1e
ToppCellfacs-Tongue-nan-24m-Epithelial-basal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC2 CRIP1 TNFRSF4

3.95e-04178363c92d7493853a717e2e7a76526e4e803564d182b7
ToppCelldroplet-Kidney-nan-21m-Lymphocytic|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFP CRIP1 TNFRSF4

4.01e-0417936321736ae288ea6113e2a5604fbda338fc6b2b94a8
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

LAMC2 ERBB2 FEZF1

4.01e-04179363d5763912a4ce7188535675e338799b856edb9dda
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA2C SLC30A10 CRIP1

4.08e-04180363f118c580134bdf3027e2218690cfc8a93468c1ae
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal-Mes|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA2C SLC30A10 CRIP1

4.08e-041803631ade66352570a3f869e21e1055d0a65fbf56c61d
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RASGRP4 CFP TNFRSF4

4.15e-0418136371e55acd1d8e4307e56534c74a50e7be4d1dda0d
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal-Mes-Pericyte|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA2C SLC30A10 CRIP1

4.15e-04181363634a4f4e5942473e60d08d0b0936407b04bc6b7c
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal-Mes-Pericyte-Peri_L1-6_MUSTN1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA2C SLC30A10 CRIP1

4.15e-04181363c2938cf1f5d4875be07a56a1f36c94f8eab37d99
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

B3GNT9 MEGF6 CRIP1

4.21e-041823639966f42c338cbd471efa8ffc765a6ce93693aa75
ToppCellfacs-Heart-RA|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP13 CFP CRIP1

4.21e-041823638292e8e8474c930ffb88cbab4f6ebdb6f58db645
ToppCellBasal|World / shred by cell class for mouse tongue

LAMC2 MEGF6 CRIP1

4.28e-04183363c6729a207526ff4aa48176207b9353176f631fea
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-MPO+_mono-neutrophil|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RASGRP4 CFP PITX3

4.28e-0418336301c7f01498a9894920edf8243e41187cbdf90688
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Mesenchymal-Mes-Pericyte-Peri_L1-6_MUSTN1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

B3GNT9 SLC30A10 CRIP1

4.28e-04183363944f7458b9127356815f75c88bbf7015ebdc8ec1
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

B3GNT9 MEGF6 CRIP1

4.28e-04183363274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Mesenchymal-Mes-Pericyte|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

B3GNT9 SLC30A10 CRIP1

4.28e-04183363cee6b821adff538078232689965d3e6c131e7d14
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

B3GNT9 MEGF6 CRIP1

4.35e-04184363607b55022de21ddb6a2d75e085df76df7abf6624
ToppCellCOPD-Myeloid-cMonocyte|World / Disease state, Lineage and Cell class

PELI1 CFP CSMD1

4.35e-04184363ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCellnormal_Lung-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

PELI1 RASGRP4 TNFRSF4

4.42e-04185363ea416362d3f06b4a0a7f08c2e5dbbc864f121555
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA2C MEGF6 NOTCH4

4.42e-04185363f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMC2 ERBB2 CRIP1

4.42e-04185363c82eab551f65ecebe6db908eda9f9eb3414693c7
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADRA2C CSMD1 NOTCH4

4.42e-04185363a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCellAdult-Endothelial-endothelial_cell_of_artery|Adult / Lineage, Cell type, age group and donor

ADRA2C CSMD1 NOTCH4

4.49e-041863632d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCellILEUM-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PER1 AKAP13 KMT2E

4.56e-041873630099def970fbc828756fbf853eca2ce77b8cd342
ToppCelldroplet-Tongue-nan-24m-Epithelial-basal_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC2 CRIP1 TNFRSF4

4.56e-0418736313056622d9921ee0b03325701d94df82ffbaa5d4
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA2C MEGF6 NOTCH4

4.56e-04187363e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PER1 CRIP1 TNFRSF4

4.63e-041883633e3055dacc05a932f2beb114babf1dc76994e1af
ToppCell3'_v3-GI_small-bowel|World / Manually curated celltypes from each tissue

AKAP13 KMT2E CRIP1

4.63e-04188363822c6abaf7bcd6721269bdbd1f2b286ccf0aec1a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NFATC1 CRIP1 TNFRSF4

4.70e-04189363284f39dfacec76004daae9dd5317fb7b1f04fa99
ToppCellEndothelial-endothelial_cell_of_artery|World / Lineage, Cell type, age group and donor

ADRA2C CSMD1 NOTCH4

4.70e-04189363fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MEGF6 CRIP1 NOTCH4

4.70e-041893631e1afa66b32ae752c0a42b02b80f10205464569c
ToppCellhuman_hepatoblastoma-Endothelial_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

NFATC1 NOTCH4 TNFRSF4

4.78e-041903638d6ef93d69e96cd6921816d152bea3b0710cf147
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADRA2C CSMD1 NOTCH4

4.78e-04190363f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCellLAM-Epithelial-AT1|Epithelial / Condition, Lineage and Cell class

LAMC2 ERBB2 CRIP1

4.85e-041913633457e15d1e9b36a78363d46b320c4ec46b40290a
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA2C MEGF6 NOTCH4

4.85e-04191363b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

LAMC2 AKAP13 NFATC1

4.92e-041923638b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCellControl-Treg|Control / Disease group and Cell class

PELI1 RASGRP4 TNFRSF4

4.92e-041923633a9a8ac2aa278adde848608f9bb92a002dbb9bcc
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DACT2 LAMC2 FOXN4

4.92e-041923638898332387e5d746feb346ce1dabd6b2218fc6e5
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CSMD1 MEGF6 CRIP1

5.00e-04193363360079cbaa18b74e4a48c5de40844faca076e1a6
ToppCellfacs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP3 NFATC1 CRIP1

5.00e-04193363eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DACT2 CRIP1 TNFRSF4

5.00e-041933637deb439943d35a4e825674b2b7dcddb45d366ad1
ToppCellP28-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LTBP3 CSMD1 CRIP1

5.08e-041943633c661c6768c3f05d2aba03d329adb257ca201b2d
ToppCell390C-Lymphocytic-CD4_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NFATC1 CRIP1 TNFRSF4

5.08e-0419436376c4c3ba5f1bcc39d397c90db3513f5bea632b1b
ToppCellfacs-Skin-Anagen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP3 NFATC1 CRIP1

5.08e-041943635d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCellCOPD-Myeloid-Macrophage|World / Disease state, Lineage and Cell class

PELI1 AKAP13 CSMD1

5.08e-041943637d682408e9a6239a4e47befc9376e760cc3d133a
ToppCell(1)_Osterolineage_cells-(11)_OLC-2|World / Cell class and subclass of bone marrow stroma cells in homeostatis

B3GNT9 MEGF6 CRIP1

5.15e-0419536378978d85273e5463a7f43e4c121e647fa6aba42b
ToppCellPCW_05-06-Endothelial-Endothelial_mature|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CFP NOTCH4 TNFRSF4

5.15e-0419536354fde2cfa51ab3a2d48d2426494ca6f0ce77f725
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Trm_Th1/Th17|Liver / Manually curated celltypes from each tissue

PER1 CRIP1 TNFRSF4

5.15e-04195363480cc62ee1e5b1aaf6b62be6e5afd7a81236a1b0
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-Trm_Th1/Th17|lymph-node_spleen / Manually curated celltypes from each tissue

PER1 CRIP1 TNFRSF4

5.15e-04195363c60982804a74dbe6607c021799ca74af2204aba8
ToppCelllymphoid-T_cell-unlabelled(multiplets)|World / Lineage, cell class and subclass

PER1 AKAP13 TNFRSF4

5.23e-0419636378b006922307c154622d71fcbc79ae5eed3f4b23
ToppCellCV-Moderate-6|CV / Virus stimulation, Condition and Cluster

AKAP13 CRIP1 TNFRSF4

5.23e-041963637bced0cc2112697593c478fa291b8ed3941fb811
ToppCell11.5-Airway-Endothelial-Endothelial|Airway / Age, Tissue, Lineage and Cell class

CFP NOTCH4 TNFRSF4

5.23e-04196363509ddea8d6e1d0b832f69490ab8a736af4ca19a8
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NFATC1 NOTCH4 TNFRSF4

5.23e-04196363629236f95c838a473b5964a49b7c1b7ad863ea12
ToppCell11.5-Airway-Endothelial|Airway / Age, Tissue, Lineage and Cell class

CFP NOTCH4 TNFRSF4

5.23e-04196363e7d55933e23599122e20498548abf5b30fc25c8f
ToppCell(4)_Endothelial_cells-(41)_EC-arteriolar|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

AKAP13 CRIP1 NOTCH4

5.31e-04197363482e3f8926880afed88ed37553ed2b5ed58b8c99
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PELI1 AKAP13 NFATC1

5.31e-04197363b597c292fc1cb381a4325fed15a32966c38def28
ToppCellwk_08-11-Hematologic-Myeloid-APOE+_Mac1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CFP NFATC1 TNFRSF4

5.31e-04197363121ec3f6d978de2f6c2cc397f7327d2e5587ab8b
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_2|COVID-19_Mild / Disease condition and Cell class

PER1 PELI1 CFP

5.31e-04197363e844f660010d114d65bd814f3d3fccd8e4a6b8da
ToppCell10x5'-Liver-Lymphocytic_T_CD4|Liver / Manually curated celltypes from each tissue

PER1 PELI1 TNFRSF4

5.31e-041973634891111894b741555f549deec6af8006376d9358
ToppCellBronchial_Brush-Epithelial-Basal_1|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

DACT2 MEGF6 EVPLL

5.31e-04197363f5d87824c0020c95d89e069fd9f70b49e5d5fcea
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_naive-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RASGRP4 CFP CRIP1

5.31e-04197363ad4147435ac0fdf6274fea6d535f4e00d990e535
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

LAMC2 ERBB2 LTBP3

5.39e-04198363b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellremission-NK|World / disease stage, cell group and cell class

AKAP13 ERBB2 CRIP1

5.39e-04198363383ed78164ad37826100d3de6c3cc14f62e01813
ToppCellBronchial_Brush-Epithelial-Basal_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DACT2 MEGF6 EVPLL

5.39e-0419836310a17d7c116dcd6cf847fe6f5d7196d887cad1f9
ToppCellcontrol-Myeloid|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PELI1 RASGRP4 CFP

5.39e-04198363abf08cde20c1843d54ba008c1db5a6ab376c761e
ToppCell18-Distal-Endothelial|Distal / Age, Tissue, Lineage and Cell class

CFP NOTCH4 TNFRSF4

5.39e-04198363ee657a84928d54eb7a9a66c7acb19a7c119d6423
ComputationalGenes in the cancer module 97.

PELI1 PRKCI NFATC1 PKD1

4.19e-0598224MODULE_97
ComputationalGenes in the cancer module 262.

PELI1 PRKCI NFATC1 PKD1

4.54e-05100224MODULE_261
ComputationalGenes in the cancer module 182.

PELI1 PRKCI NFATC1 PKD1

4.54e-05100224MODULE_182
Diseaseinterstitial lung disease

AKAP13 CSMD1 NOTCH4

7.57e-0567363EFO_0004244
DiseaseAmelogenesis Imperfecta

LAMC2 LTBP3

9.48e-0512362C0002452
Diseasetriacylglycerol 52:1 measurement

CSMD1 NFATC1

1.30e-0414362EFO_0010413
Diseasetriacylglycerol 46:1 measurement

CSMD1 NFATC1

2.71e-0420362EFO_0010401
Diseasearginine measurement

LAMC2 CSMD1

3.60e-0423362EFO_0020990
DiseaseFEV/FEC ratio

LAMC2 LTBP3 CSMD1 MEGF6 WWC3 NFATC1 SLC30A10

6.15e-041228367EFO_0004713
Diseaseaspartate aminotransferase measurement

AKAP13 PRKCI CSMD1 WWC3 SLC30A10 NOTCH4

7.22e-04904366EFO_0004736
DiseaseNeoplasm Recurrence, Local

ERBB2 PITX3

1.04e-0339362C0027643
Diseasecannabis dependence measurement

PAX1 CSMD1

1.58e-0348362EFO_0008457
Diseaseeosinophil count

RASGRP4 AKAP13 PRKCI LTBP3 ZDHHC8 NOTCH4 TNFRSF4

1.88e-031488367EFO_0004842
Diseaseserum selenium measurement

MED25 CSMD1

1.92e-0353362EFO_0005266
Diseaseresponse to lithium ion

MEGF6 NOTCH4

2.14e-0356362GO_0010226

Protein segments in the cluster

PeptideGeneStartEntry
FCPDPAPGAGGMVHH

ERBB2

1031

P04626
PAHNTCPDPGTPHFG

CSMD1

3211

Q96PZ7
AAAGAGENGHCAPPP

ADRA2C

266

P18825
SHHEHPFPGDGCTGP

AKAP13

261

Q12802
GGHAEHEGKPYCNHP

CRIP1

41

P50238
PPGFLHCASFGDPHV

HJV

161

Q6ZVN8
GCHPQTGFADIQGHP

PRKCI

506

P41743
ALGERGCHHGPAPPS

PER1

816

O15534
AAEPGGAGCRHHPEP

EVPLL

151

A8MZ36
GNFPFACHGLHPPPR

RASGRP4

496

Q8TDF6
ASPGHCHLGLPQPAG

NFATC1

781

O95644
FCPHPGSVALPHGVQ

KMT2E

1811

Q8IZD2
GNGFAGCVHFPHTAP

MED25

491

Q71SY5
HPVPQHGGPFCAGDA

CFP

286

P27918
PPAHGVSCHGPYEAA

ACP4

371

Q9BZG2
GAQALPDCAGPSPGH

PAX1

66

P15863
GLQLDPGPHGDCTPH

CEFIP

1381

Q711Q0
PGPHGDCTPHSAGQR

CEFIP

1386

Q711Q0
PPGHHGQRAAANGFC

HDAC10

131

Q969S8
AAPCGPHGLHGPEQQ

DACT2

56

Q5SW24
GHGECVPGPPDYSCH

LTBP3

586

Q9NS15
FGDPFGEHGPVRPCQ

LAMC2

501

Q13753
PPPGFGLAHVACSGH

FAM215A

11

Q9Y5M1
AGTPHPQLPEHGCKG

PITX3

21

O75364
AGPGALLHCSPAPGH

PKD1

721

P98161
DAGPPTHAFSPCGHV

PELI1

356

Q96FA3
GQACEHPCPPGFHGA

MEGF6

1371

O75095
HPCPPGFHGAGCQGL

MEGF6

1376

O75095
CVPHPHPGALAGVAD

FOXN4

71

Q96NZ1
LDPGPPSHAFAPCGH

PELI3

406

Q8N2H9
GDGPCHPAAGVNIHP

FEZF1

166

A0PJY2
PCHNHGTCTPKPGGF

NOTCH4

976

Q99466
GPHGPACAHPQPVAA

B3GNT9

381

Q6UX72
PLAHVNGCAEHNGGP

SLC30A10

421

Q6XR72
PQAGFPHAAHPGDCP

ZXDB

211

P98169
APCPPGHFSPGDNQA

TNFRSF4

126

P43489
PGPHAPEAGAEGQHQ

nan

181

Q3C1V9
GSPGGHACPAHPAVG

ZDHHC8

486

Q9ULC8
FPHHVGVPGDAGVPQ

WWC3

191

Q9ULE0
AAPDCTPGPGFLQGH

ZNF324B

511

Q6AW86