Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	polysaccharide binding	CLEC18A CLEC18B CLEC18C	6.32e-05	31	50	3	GO:0030247
GeneOntologyMolecularFunction	DNA endonuclease activity	ERCC4 MUS81 POLQ	1.82e-04	44	50	3	GO:0004520
GeneOntologyMolecularFunction	single-stranded DNA endodeoxyribonuclease activity	ERCC4 POLQ	4.71e-04	13	50	2	GO:0000014
GeneOntologyMolecularFunction	DNA nuclease activity	ERCC4 MUS81 POLQ	6.32e-04	67	50	3	GO:0004536
GeneOntologyBiologicalProcess	dolichol-linked oligosaccharide biosynthetic process	DPAGT1 DOLK ALG3	2.00e-05	22	50	3	GO:0006488
GeneOntologyBiologicalProcess	dolichol metabolic process	DPAGT1 DOLK ALG3	2.62e-05	24	50	3	GO:0019348
GeneOntologyBiologicalProcess	polyprenol metabolic process	DPAGT1 DOLK ALG3	4.68e-05	29	50	3	GO:0016093
GeneOntologyBiologicalProcess	cytochrome metabolic process	CYP2U1 CYP2W1	8.59e-05	6	50	2	GO:1903604
HumanPheno	Type I transferrin isoform profile	DPAGT1 DOLK ALG3	3.08e-05	22	15	3	HP:0003642
HumanPheno	Abnormal enzyme concentration or activity	PHEX DPAGT1 ERCC4 B3GALNT2 GLYCTK DOLK ALG3 MCCC1 CNOT1	5.35e-05	729	15	9	HP:0034684
Domain	-	CLEC18A CLEC18B CLEC18C	8.03e-06	15	50	3	3.40.33.10
Domain	CAP	CLEC18A CLEC18B CLEC18C	8.03e-06	15	50	3	PF00188
Domain	CAP_domain	CLEC18A CLEC18B CLEC18C	8.03e-06	15	50	3	IPR014044
Domain	SCP	CLEC18A CLEC18B CLEC18C	8.03e-06	15	50	3	SM00198
Domain	Allrgn_V5/Tpx1	CLEC18A CLEC18B CLEC18C	8.03e-06	15	50	3	IPR001283
Domain	-	ERCC4 MUS81	2.10e-05	3	50	2	3.40.50.10130
Domain	DNA_repair_nuc_XPF/helicase	ERCC4 MUS81	2.10e-05	3	50	2	IPR020819
Domain	Restrct_endonuc-II-like	ERCC4 MUS81	6.99e-05	5	50	2	IPR011335
Domain	ERCC4	ERCC4 MUS81	6.99e-05	5	50	2	SM00891
Domain	ERCC4_domain	ERCC4 MUS81	6.99e-05	5	50	2	IPR006166
Domain	ERCC4	ERCC4 MUS81	6.99e-05	5	50	2	PF02732
Domain	Cyclin_L/T	CCNL2 CCNL1	1.95e-04	8	50	2	IPR015429
Domain	C-type_lectin_CS	CLEC18A CLEC18B CLEC18C	2.07e-04	43	50	3	IPR018378
Domain	Cyclin_C-dom	CCNL2 CCNL1	9.31e-04	17	50	2	IPR004367
Domain	Cyclin_C	CCNL2 CCNL1	9.31e-04	17	50	2	PF02984
Domain	Cyclin_C	CCNL2 CCNL1	9.31e-04	17	50	2	SM01332
Domain	C_TYPE_LECTIN_1	CLEC18A CLEC18B CLEC18C	1.28e-03	80	50	3	PS00615
Domain	Lectin_C	CLEC18A CLEC18B CLEC18C	1.48e-03	84	50	3	PF00059
Domain	CLECT	CLEC18A CLEC18B CLEC18C	1.48e-03	84	50	3	SM00034
Domain	C_TYPE_LECTIN_2	CLEC18A CLEC18B CLEC18C	1.53e-03	85	50	3	PS50041
Domain	AA-permease/SLC12A_dom	SLC12A9 SLC7A10	1.57e-03	22	50	2	IPR004841
Domain	AA_permease	SLC12A9 SLC7A10	1.57e-03	22	50	2	PF00324
Domain	C-type_lectin-like	CLEC18A CLEC18B CLEC18C	1.58e-03	86	50	3	IPR001304
Domain	-	CLEC18A CLEC18B CLEC18C	2.23e-03	97	50	3	3.10.100.10
Domain	C-type_lectin-like/link	CLEC18A CLEC18B CLEC18C	2.36e-03	99	50	3	IPR016186
Domain	CYCLINS	CCNL2 CCNL1	2.54e-03	28	50	2	PS00292
Domain	CTDL_fold	CLEC18A CLEC18B CLEC18C	2.95e-03	107	50	3	IPR016187
Domain	Cyclin_N	CCNL2 CCNL1	3.52e-03	33	50	2	IPR006671
Domain	Cyclin_N	CCNL2 CCNL1	3.52e-03	33	50	2	PF00134
Domain	GPS	ADGRF1 PKDREJ	3.73e-03	34	50	2	SM00303
Domain	GPS	ADGRF1 PKDREJ	4.41e-03	37	50	2	IPR000203
Domain	CYCLIN	CCNL2 CCNL1	4.64e-03	38	50	2	SM00385
Domain	EGF_1	CLEC18A CLEC18B NTN5 CLEC18C	4.78e-03	255	50	4	PS00022
Domain	-	CCNL2 CCNL1	5.13e-03	40	50	2	1.10.472.10
Domain	EGF_2	CLEC18A CLEC18B NTN5 CLEC18C	5.47e-03	265	50	4	PS01186
Domain	ABC_transporter_CS	ABCB8 ABCA7	5.65e-03	42	50	2	IPR017871
Domain	Cyclin-like	CCNL2 CCNL1	5.91e-03	43	50	2	IPR013763
Domain	Cyt_P450_E_grp-I	CYP2U1 CYP2W1	6.46e-03	45	50	2	IPR002401
Domain	ABC_TRANSPORTER_2	ABCB8 ABCA7	7.32e-03	48	50	2	PS50893
Domain	ABC_tran	ABCB8 ABCA7	7.32e-03	48	50	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCB8 ABCA7	7.62e-03	49	50	2	PS00211
Domain	ABC_transporter-like	ABCB8 ABCA7	7.93e-03	50	50	2	IPR003439
Domain	Cyt_P450_CS	CYP2U1 CYP2W1	8.87e-03	53	50	2	IPR017972
Domain	CYTOCHROME_P450	CYP2U1 CYP2W1	1.02e-02	57	50	2	PS00086
Domain	-	CYP2U1 CYP2W1	1.06e-02	58	50	2	1.10.630.10
Domain	p450	CYP2U1 CYP2W1	1.06e-02	58	50	2	PF00067
Pathway	WP_GLYCOSYLATION_AND_RELATED_CONGENITAL_DEFECTS	DPAGT1 DOLK ALG3	3.38e-05	25	36	3	M39813
Pathway	REACTOME_DISEASES_OF_METABOLISM	DPAGT1 DOLK CYP2U1 ALG3 MCCC1	4.05e-04	250	36	5	M27554
Pathway	WP_NGLYCAN_BIOSYNTHESIS	DPAGT1 DOLK ALG3	4.07e-04	57	36	3	M48051
Pathway	KEGG_MEDICUS_REFERENCE_COPII_VESICLE_FORMATION	PREB SEC24B	4.12e-04	12	36	2	M47770
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP2U1 CYP2W1	4.12e-04	12	36	2	M27128
Pathway	KEGG_MEDICUS_REFERENCE_LESION_BYPASS_BY_TLS_AND_DSB_FORMATION	ERCC4 MUS81	6.52e-04	15	36	2	M47854
Pathway	REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION	PREB DPAGT1 SEC24B DOLK ALG3	8.33e-04	293	36	5	MM15120
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP2U1 CYP2W1	9.46e-04	18	36	2	MM14843
Pathway	REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN	DPAGT1 DOLK ALG3	9.83e-04	77	36	3	MM15118
Pathway	REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION	PREB DPAGT1 SEC24B DOLK ALG3	1.03e-03	307	36	5	M894
Pathway	REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN	DPAGT1 DOLK ALG3	1.06e-03	79	36	3	M897
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_N_GLYCOSYLATION_OF_PROTEINS	DPAGT1 ALG3	1.17e-03	20	36	2	M27274
Pubmed	The C-type lectin-like domain superfamily.	CLEC18A CLEC18B CLEC18C	3.15e-09	3	52	3	16336259
Pubmed	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.	CLEC18A CLEC18B CLEC18C	3.15e-09	3	52	3	33603190
Pubmed	Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.	CLEC18A CLEC18B CLEC18C	3.15e-09	3	52	3	26170455
Pubmed	The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.	CLEC18A CLEC18B CLEC18C	1.26e-08	4	52	3	16709836
Pubmed	The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage.	ERCC4 MUS81	2.19e-06	2	52	2	25879486
Pubmed	Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.	ERCC4 MUS81	2.19e-06	2	52	2	29739952
Pubmed	Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.	CCNL2 CCNL1	6.57e-06	3	52	2	18216018
Pubmed	CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing.	CCNL2 CCNL1	6.57e-06	3	52	2	17261272
Pubmed	Characterization of cyclin L1 as an immobile component of the splicing factor compartment.	CCNL2 CCNL1	6.57e-06	3	52	2	17494991
Pubmed	Localization-dependent and -independent roles of SLX4 in regulating telomeres.	ERCC4 MUS81	1.31e-05	4	52	2	23994477
Pubmed	Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing.	NPTN MYO15A	1.31e-05	4	52	2	35100259
Pubmed	Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.	CCNL2 CCNL1	1.31e-05	4	52	2	2217177
Pubmed	Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia.	ERCC4 MUS81	1.31e-05	4	52	2	23623386
Pubmed	Mutations of the SLX4 gene in Fanconi anemia.	ERCC4 MUS81	1.31e-05	4	52	2	21240275
Pubmed	CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.	CCNL2 CCNL1	1.31e-05	4	52	2	24436071
Pubmed	Whole exome sequencing reveals uncommon mutations in the recently identified Fanconi anemia gene SLX4/FANCP.	ERCC4 MUS81	1.31e-05	4	52	2	23033263
Pubmed	Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.	CCNL2 CCNL1	2.19e-05	5	52	2	11683997
Pubmed	CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway.	CCNL2 CCNL1	2.19e-05	5	52	2	17516030
Pubmed	SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.	ERCC4 MUS81	2.19e-05	5	52	2	25722289
Pubmed	Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4.	ERCC4 MUS81	2.19e-05	5	52	2	23093618
Pubmed	UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold.	ERCC4 MUS81	2.19e-05	5	52	2	25818288
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	CLEC18A CLEC18B CLEC18C	2.36e-05	37	52	3	22432025
Pubmed	SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.	ERCC4 MUS81	3.28e-05	6	52	2	24012755
Pubmed	Congenital Disorders of N-Linked Glycosylation and Multiple Pathway Overview	DPAGT1 DOLK ALG3	4.00e-05	44	52	3	20301507
Pubmed	Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.	ALG3 CNOT1	4.58e-05	7	52	2	29547901
Pubmed	Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.	ERCC4 MUS81	4.58e-05	7	52	2	19595721
Pubmed	From arrest to escape: HIV-1 Vpr cuts a deal.	ERCC4 MUS81	4.58e-05	7	52	2	24528857
Pubmed	Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.	ERCC4 MUS81	6.10e-05	8	52	2	19596236
Pubmed	DNA damage repair machinery and HIV escape from innate immune sensing.	ERCC4 MUS81	6.10e-05	8	52	2	24795708
Pubmed	Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.	CCNL2 CCNL1	7.84e-05	9	52	2	14623875
Pubmed	USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.	ERCC4 MUS81	9.79e-05	10	52	2	25538220
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	CLEC18A CLEC18B C6orf15 CCNL1 DOLK DHRS13 ZNF767P IL27RA	1.00e-04	985	52	8	12975309
Pubmed	Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.	ERCC4 MUS81	1.20e-04	11	52	2	24412650
Pubmed	A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.	SEC24B NDST4 CYP2U1	1.23e-04	64	52	3	20332099
Pubmed	Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.	ERCC4 MUS81	1.69e-04	13	52	2	25533185
Pubmed	Variation within DNA repair pathway genes and risk of multiple sclerosis.	ERCC4 MUS81 XAB2	1.75e-04	72	52	3	20522537
Pubmed	Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.	ERCC4 MUS81	2.27e-04	15	52	2	17289582
Pubmed	SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations.	ERCC4 MUS81	2.27e-04	15	52	2	32398829
Pubmed	Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.	ERCC4 XAB2	2.60e-04	16	52	2	11313499
Pubmed	Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.	ERCC4 MUS81 NUP188	2.86e-04	85	52	3	19596235
Pubmed	A mega-analysis of genome-wide association studies for major depressive disorder.	HTR3D ALG3	3.69e-04	19	52	2	22472876
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	PREB NPTN SLC12A9 SEC24B RHBDD3 NUP188 ESPL1	4.84e-04	942	52	7	31073040
Pubmed	Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.	ERCC4 MUS81	4.97e-04	22	52	2	22902628
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCB8 ABCA7	5.44e-04	23	52	2	10708515
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	CLEC18A CLEC18B C6orf15 DOLK CLEC18C	6.17e-04	460	52	5	20562862
Pubmed	In vivo validation of late-onset Alzheimer's disease genetic risk factors.	ABCA7 CEACAM1	6.43e-04	25	52	2	38687251
Pubmed	Keratin 13 deficiency causes white sponge nevus in mice.	CCNL2 CCNL1	1.12e-03	33	52	2	32758484
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ARHGAP4 DOLK NUP188 ESPL1 CNOT1	1.15e-03	529	52	5	14621295
Pubmed	A genome-wide association study (GWAS) for bronchopulmonary dysplasia.	NDST4 CYP2W1	1.19e-03	34	52	2	23897914
Pubmed	SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.	ERCC4 MUS81	1.19e-03	34	52	2	31495888
Cytoband	Ensembl 112 genes in cytogenetic band chr3q27	HTR3D ALG3 MCCC1	4.23e-04	128	52	3	chr3q27
Cytoband	3q27.1	HTR3D ALG3	4.34e-04	27	52	2	3q27.1
Cytoband	9q34.11	DOLK NUP188	1.67e-03	53	52	2	9q34.11
Cytoband	4q25	SEC24B CYP2U1	2.65e-03	67	52	2	4q25
Cytoband	2p23.3	PREB KRTCAP3	2.73e-03	68	52	2	2p23.3
GeneFamily	C-type lectin domain family	CLEC18A CLEC18B CLEC18C	1.11e-04	47	36	3	494
GeneFamily	Cyclins	CCNL2 CCNL1	1.41e-03	28	36	2	473
GeneFamily	Cytochrome P450 family 2	CYP2U1 CYP2W1	2.20e-03	35	36	2	1001
Drug	Felbinac [5728-52-9]; Down 200; 18.8uM; HL60; HT_HG-U133A	ZSWIM8 DOLK NT5M CYP2W1 IL27RA CEACAM1	5.37e-06	199	51	6	3061_DN
Disease	2'-O-methylcytidine measurement	DOLK NUP188	2.80e-05	5	50	2	EFO_0800635
Disease	Congenital disorder of glycosylation	DPAGT1 DOLK ALG3	3.70e-05	38	50	3	cv:C0282577
Disease	amino acid measurement	ABCB8 CLEC18C HTR3D MCCC1 IL27RA	5.70e-03	678	50	5	EFO_0005134
Disease	leucine measurement	CLEC18C IL27RA	6.85e-03	73	50	2	EFO_0009770
Disease	intellectual disability (implicated_via_orthology)	PREB NDST4	7.22e-03	75	50	2	DOID:1059 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRLIGWASRSLHPLP	CCSMST1	16	Q4G0I0
LLLLRWRRPALHRPI	SLC7A10	406	Q9NS82
WRRPALHRPIKVNLL	SLC7A10	411	Q9NS82
LLKPPLLWSHGLIRI	ADGRF1	71	Q5T601
PARWLTHLLRLLVLG	ALG3	376	Q92685
PWLGALLQLHRPVLR	CYP2W1	221	Q8TAV3
ALQIPLPTRPHWFLL	CCNL1	256	Q9UK58
SHPLSRLLWRRLKPL	ABCA7	276	Q8IZY2
LSLGVVLPWLHRLIR	DOLK	266	Q9UPQ8
VLPWLHRLIRRNPLL	DOLK	271	Q9UPQ8
SLNLPSRLPHTWRRL	MYO15A	861	Q9UKN7
RWRHKLLLPTAASLP	DPAGT1	121	Q9H3H5
GPILRLHLPDNTLRW	IL27RA	501	Q6UWB1
PVLRHPLAWILLLSL	NIPA2	211	Q8N8Q9
DLLPQEHILLRTRPW	TEPSIN	311	Q96N21
KLLHRLGQPLPSWLR	NDST4	851	Q9H3R1
LSQRPPWSLIHRVLP	C6orf15	191	Q6UXA7
WPARLLRAPLGLLRL	CYP2U1	16	Q7Z449
ARIPHLEPWRASLLL	ESPL1	1256	Q14674
LARAPLHPLLWRGSV	GLYCTK	11	Q8IVS8
APLHRVRVPWQGLLL	CEACAM1	6	P13688
TLEIPLPNRPHWFLL	CCNL2	251	Q96S94
ALHLWLRLRSPPPAC	B3GALNT2	16	Q8NCR0
HPLPGLILEWRRITN	POLQ	2191	O75417
RNRWHRLPSLLLPPR	MCCC1	16	Q96RQ3
WLRDSRPLSPILHIV	SEC24B	1216	O95487
LLRPLAWLVLRAPRG	DHRS13	246	Q6UX07
LASRNLLRPPLHWVL	KRTCAP3	81	Q53RY4
LLRPPLHWVLLALAL	KRTCAP3	86	Q53RY4
LHLGLPWRMLRPQLV	PPEF2	601	O14830
LRSQLWAHLPRAPLA	ABCB8	66	Q9NUT2
HLQLQPPRRRLHSWA	NT5M	201	Q9NPB1
ALRALPITQHSRIWP	XAB2	136	Q9HCS7
PTRLILDRHGLALPW	NTN5	441	Q8WTR8
LDLRVLLSAQRLPWP	PKDREJ	91	Q9NTG1
LSLLNHKLPARVWLP	PI4KB	356	Q9UBF8
HVSRLLWRLPAPVLV	ARHGAP4	616	P98171
HLNLPPLLVLPTRWS	SNAI3	111	Q3KNW1
LHVATTQPLPLPRWL	HTR3D	331	Q70Z44
TQPLPLPRWLHSLLL	HTR3D	336	Q70Z44
LLSLHNRLRSWVQPP	CLEC18A	51	A5D8T8
LLSLHNRLRSWVQPP	CLEC18B	51	Q6UXF7
LLSLHNRLRSWVQPP	CLEC18C	51	Q8NCF0
RLIVNRPHPWGLLIT	CNOT1	2311	A5YKK6
PELLLDPWQVHRLLT	RHBDD3	41	Q9Y3P4
NLLHNRNFWILRLPP	ZNF767P	86	Q75MW2
HLLPSRRSVPVWLLL	PREB	381	Q9HCU5
WLRLLERALPGRAPH	MPV17L	66	Q2QL34
SPAALQRRLPILAWL	SLC26A11	26	Q86WA9
LHHVDVWPLNLLRPR	SLC12A9	721	Q9BXP2
LRVRSHLAPLWPFLG	NPTN	331	Q9Y639
PVLLAWALLRHTLNP	NUP188	321	Q5SRE5
LLHILRHSPFRWPVL	PHEX	156	P78562
LWRLAVLDPALSPQR	ZSWIM8	426	A7E2V4
LTLHFPRLRILWCPS	ERCC4	791	Q92889
AVWRHLLPALLLLVL	TMEM239	141	Q8WW34
PWPALRSLLHRNLVL	MUS81	181	Q96NY9