Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of vasoconstriction	FGA AHR ACE2 FGG CHRM3	2.83e-07	98	30	5	GO:0019229
GeneOntologyBiologicalProcess	vasoconstriction	FGA AHR ACE2 FGG CHRM3	8.10e-07	121	30	5	GO:0042310
GeneOntologyBiologicalProcess	blood vessel diameter maintenance	FGA AHR ACE2 FGG CHRM3	1.00e-05	202	30	5	GO:0097746
GeneOntologyBiologicalProcess	regulation of tube diameter	FGA AHR ACE2 FGG CHRM3	1.00e-05	202	30	5	GO:0035296
GeneOntologyBiologicalProcess	regulation of tube size	FGA AHR ACE2 FGG CHRM3	1.03e-05	203	30	5	GO:0035150
GeneOntologyBiologicalProcess	positive regulation of vasoconstriction	FGA FGG CHRM3	6.55e-05	54	30	3	GO:0045907
GeneOntologyBiologicalProcess	regulation of blood circulation	FGA AHR ACE2 FGG CHRM3	9.85e-05	326	30	5	GO:1903522
GeneOntologyBiologicalProcess	vascular process in circulatory system	FGA AHR ACE2 FGG CHRM3	1.27e-04	344	30	5	GO:0003018
GeneOntologyBiologicalProcess	skin development	FLNB LIPK SCD5 LGR5 TP63	1.85e-04	373	30	5	GO:0043588
GeneOntologyBiologicalProcess	positive regulation of heterotypic cell-cell adhesion	FGA FGG	2.12e-04	15	30	2	GO:0034116
GeneOntologyBiologicalProcess	blood coagulation, fibrin clot formation	FGA FGG	2.74e-04	17	30	2	GO:0072378
GeneOntologyCellularComponent	fibrinogen complex	FGA FGG	5.55e-05	8	30	2	GO:0005577
GeneOntologyCellularComponent	platelet alpha granule	FGA THBS2 FGG	3.17e-04	93	30	3	GO:0031091
GeneOntologyCellularComponent	brush border	ACE2 FLNB PLD2	1.32e-03	152	30	3	GO:0005903
GeneOntologyCellularComponent	Cul4-RING E3 ubiquitin ligase complex	ERCC8 DCAF11	1.36e-03	38	30	2	GO:0080008
HumanPheno	Subdural hemorrhage	FGA ERCC8 FGG	5.91e-06	14	14	3	HP:0100309
HumanPheno	Afibrinogenemia	FGA FGG	2.10e-05	3	14	2	HP:0034287
HumanPheno	Splenic rupture	FGA FGG	6.98e-05	5	14	2	HP:0012223
HumanPheno	Menometrorrhagia	FGA FGG	6.98e-05	5	14	2	HP:0400008
HumanPheno	Epidural hemorrhage	FGA FGG	1.05e-04	6	14	2	HP:0100310
HumanPheno	Abnormal umbilical stump bleeding	FGA FGG	1.95e-04	8	14	2	HP:0011884
HumanPheno	Congenital bleeding diathesis	FGA FGG	1.95e-04	8	14	2	HP:0004834
MousePheno	vaginal hemorrhage	FGA FGG	9.97e-06	3	26	2	MP:0031137
MousePheno	abnormal skin physiology	FGA AHR ERCC8 THBS2 SCD5 TP63	1.18e-05	288	26	6	MP:0005501
MousePheno	decreased circulating fibrinogen level	FGA FGG	1.99e-05	4	26	2	MP:0012330
MousePheno	spontaneous skin ulceration	AHR SCD5 TP63	2.02e-05	29	26	3	MP:0001209
MousePheno	abnormal uterus physiology	FGA FGG TP63	2.24e-05	30	26	3	MP:0009671
MousePheno	abnormal vagina physiology	FGA FGG	3.32e-05	5	26	2	MP:0031162
MousePheno	photophobia	ERCC8 SCD5	3.32e-05	5	26	2	MP:0013787
MousePheno	uterine hemorrhage	FGA FGG	4.97e-05	6	26	2	MP:0004898
MousePheno	abnormal skin condition	AHR ERCC8 SCD5 TP63 HTT	5.38e-05	227	26	5	MP:0001191
MousePheno	acanthosis	AHR SCD5 TP63	6.71e-05	43	26	3	MP:0001874
MousePheno	epidermis stratum spinosum hyperplasia	AHR SCD5 TP63	7.70e-05	45	26	3	MP:0009611
MousePheno	abnormal circulating fibrinogen level	FGA FGG	9.25e-05	8	26	2	MP:0010213
MousePheno	abnormal behavioral response to light	ERCC8 SCD5	9.25e-05	8	26	2	MP:0011275
MousePheno	photosensitivity	ERCC8 SCD5	1.48e-04	10	26	2	MP:0001999
MousePheno	abnormal respiratory system physiology	AHR ACE2 FLNB FLNC HIGD1C LGR5 CHRM3 MARCHF6	1.54e-04	897	26	8	MP:0002133
MousePheno	decreased acute phase protein level	FGA FGG	1.81e-04	11	26	2	MP:0014500
MousePheno	abnormal urinary bladder urothelium morphology	AHR TP63	1.81e-04	11	26	2	MP:0000540
MousePheno	abnormal piliary canal morphology	AHR SCD5	2.17e-04	12	26	2	MP:0030570
MousePheno	hemoperitoneum	FGA FGG	2.17e-04	12	26	2	MP:0005435
MousePheno	abnormal epidermis stratum spinosum morphology	AHR SCD5 TP63	2.31e-04	65	26	3	MP:0001236
MousePheno	abnormal prostate gland morphology	AHR THBS2 TP63	3.26e-04	73	26	3	MP:0001158
MousePheno	abnormal hair shaft morphology	AHR SCD5 TP63	3.53e-04	75	26	3	MP:0003809
MousePheno	abnormal wound healing	FGA ACE2 THBS2 TP63	4.15e-04	193	26	4	MP:0005023
MousePheno	genital hemorrhage	FGA FGG	4.45e-04	17	26	2	MP:0004245
MousePheno	abnormal urothelium morphology	AHR TP63	6.19e-04	20	26	2	MP:0003630
MousePheno	skin lesions	AHR SCD5 TP63	6.23e-04	91	26	3	MP:0001212
MousePheno	abnormal respiration	ACE2 FLNB FLNC HIGD1C LGR5 MARCHF6	6.61e-04	598	26	6	MP:0001943
MousePheno	thick dermal layer	SCD5 TP63	7.51e-04	22	26	2	MP:0001245
MousePheno	distended urinary bladder	CHRM3 TP63	8.22e-04	23	26	2	MP:0000539
MousePheno	abnormal female reproductive system physiology	CPEB3 FGA AHR FGG SCD5 THOC3 TP63	8.50e-04	876	26	7	MP:0003699
MousePheno	abnormal blood coagulation	FGA AHR THBS2 FGG	9.41e-04	240	26	4	MP:0002551
MousePheno	abnormal hemostasis	FGA AHR THBS2 FGG	9.71e-04	242	26	4	MP:0009676
MousePheno	abnormal acute phase protein level	FGA FGG	9.72e-04	25	26	2	MP:0010211
MousePheno	decreased skin tensile strength	THBS2 SCD5	1.05e-03	26	26	2	MP:0003089
MousePheno	abnormal cutaneous collagen fibril morphology	THBS2 SCD5	1.13e-03	27	26	2	MP:0008438
MousePheno	decreased secondary ovarian follicle number	CPEB3 AHR	1.13e-03	27	26	2	MP:0031381
MousePheno	alopecia	AHR SCD5 TP63	1.26e-03	116	26	3	MP:0000414
MousePheno	rectal prolapse	AHR TP63	1.31e-03	29	26	2	MP:0000493
MousePheno	wrinkled skin	SCD5 TP63	1.50e-03	31	26	2	MP:0001211
MousePheno	abnormal cauda epididymis morphology	AHR CFAP44	1.50e-03	31	26	2	MP:0002662
MousePheno	abnormal skin tensile strength	THBS2 SCD5	1.59e-03	32	26	2	MP:0005275
MousePheno	decreased corpora lutea number	CPEB3 AHR	1.70e-03	33	26	2	MP:0002680
MousePheno	abnormal food intake	FLNC SCD5 LGR5 CHRM3 TP63	1.71e-03	481	26	5	MP:0005449
MousePheno	increased susceptibility to bacterial infection	AHR ACE2 FGG SCD5	1.73e-03	283	26	4	MP:0002412
MousePheno	abnormal lung elastance	ACE2 MARCHF6	1.80e-03	34	26	2	MP:0011043
MousePheno	abnormal secondary ovarian follicle number	CPEB3 AHR	1.91e-03	35	26	2	MP:0031380
MousePheno	abnormal carpal bone morphology	FLNB TP63	2.02e-03	36	26	2	MP:0000554
MousePheno	increased susceptibility to infection	AHR ACE2 FGG SCD5 TP63	2.10e-03	504	26	5	MP:0002406
MousePheno	pulmonary edema	AHR ACE2	2.13e-03	37	26	2	MP:0003828
MousePheno	abnormal urinary bladder physiology	AHR CHRM3	2.13e-03	37	26	2	MP:0010386
MousePheno	abnormal secondary ovarian follicle morphology	CPEB3 AHR	2.13e-03	37	26	2	MP:0021106
MousePheno	abnormal physical strength	FLNC NSL1 THOC3 LGR5 TP63 HTT MARCHF6	2.15e-03	1027	26	7	MP:0004262
Domain	Fibrinogen_a/b/g_coil_dom	FGA FGG	7.48e-06	3	30	2	IPR012290
Domain	Fib_alpha	FGA FGG	7.48e-06	3	30	2	SM01212
Domain	Fib_alpha	FGA FGG	7.48e-06	3	30	2	PF08702
Domain	IG_FLMN	FLNB FLNC	1.11e-04	10	30	2	SM00557
Domain	Filamin	FLNB FLNC	1.36e-04	11	30	2	PF00630
Domain	Filamin/ABP280_rpt	FLNB FLNC	1.36e-04	11	30	2	IPR001298
Domain	Filamin/ABP280_repeat-like	FLNB FLNC	1.36e-04	11	30	2	IPR017868
Domain	FILAMIN_REPEAT	FLNB FLNC	1.36e-04	11	30	2	PS50194
Domain	G-protein_beta_WD-40_rep	ERCC8 DCAF11 THOC3	3.38e-04	85	30	3	IPR020472
Domain	Fibrinogen_CS	FGA FGG	4.19e-04	19	30	2	IPR020837
Domain	Actinin_actin-bd_CS	FLNB FLNC	6.18e-04	23	30	2	IPR001589
Domain	ACTININ_2	FLNB FLNC	6.18e-04	23	30	2	PS00020
Domain	ACTININ_1	FLNB FLNC	6.18e-04	23	30	2	PS00019
Domain	-	FGA FGG	6.73e-04	24	30	2	4.10.530.10
Domain	Fibrinogen_a/b/g_C_2	FGA FGG	6.73e-04	24	30	2	IPR014715
Domain	WD40	ERCC8 DCAF11 THOC3 CFAP44	7.46e-04	259	30	4	PF00400
Domain	WD40	ERCC8 DCAF11 THOC3 CFAP44	8.47e-04	268	30	4	SM00320
Domain	Fibrinogen_C	FGA FGG	8.54e-04	27	30	2	PF00147
Domain	WD40_repeat	ERCC8 DCAF11 THOC3 CFAP44	8.95e-04	272	30	4	IPR001680
Domain	WD_REPEATS_1	ERCC8 DCAF11 THOC3 CFAP44	9.70e-04	278	30	4	PS00678
Domain	WD_REPEATS_2	ERCC8 DCAF11 THOC3 CFAP44	9.83e-04	279	30	4	PS50082
Domain	WD_REPEATS_REGION	ERCC8 DCAF11 THOC3 CFAP44	9.83e-04	279	30	4	PS50294
Domain	FBG	FGA FGG	9.86e-04	29	30	2	SM00186
Domain	-	FGA FGG	1.06e-03	30	30	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	FGA FGG	1.06e-03	30	30	2	IPR014716
Domain	Fibrinogen_a/b/g_C_dom	FGA FGG	1.20e-03	32	30	2	IPR002181
Domain	FIBRINOGEN_C_2	FGA FGG	1.20e-03	32	30	2	PS51406
Domain	FIBRINOGEN_C_1	FGA FGG	1.20e-03	32	30	2	PS00514
Domain	WD40_repeat_dom	ERCC8 DCAF11 THOC3 CFAP44	1.24e-03	297	30	4	IPR017986
Domain	-	ERCC8 DCAF11 THOC3 CFAP44	1.89e-03	333	30	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	ERCC8 DCAF11 THOC3 CFAP44	1.93e-03	335	30	4	IPR015943
Domain	CH	FLNB FLNC	4.87e-03	65	30	2	SM00033
Domain	CH	FLNB FLNC	5.63e-03	70	30	2	PF00307
Domain	-	FLNB FLNC	5.79e-03	71	30	2	1.10.418.10
Domain	CH	FLNB FLNC	6.11e-03	73	30	2	PS50021
Domain	CH-domain	FLNB FLNC	6.44e-03	75	30	2	IPR001715
Pathway	WP_COVID19_THROMBOSIS_AND_ANTICOAGULATION	FGA FGG	7.38e-05	7	27	2	M39868
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COAGULATION_CASCADE_FIBRINOGEN_TO_FIBRIN	FGA FGG	1.57e-04	10	27	2	M47879
Pathway	WP_NPHP1_DELETION_SYNDROME	FLNB FLNC	1.92e-04	11	27	2	M48099
Pathway	BIOCARTA_FIBRINOLYSIS_PATHWAY	FGA FGG	2.30e-04	12	27	2	M2842
Pathway	BIOCARTA_FIBRINOLYSIS_PATHWAY	FGA FGG	2.30e-04	12	27	2	MM1398
Pathway	PID_INTEGRIN1_PATHWAY	FGA THBS2 FGG	2.65e-04	66	27	3	M18
Pathway	BIOCARTA_EXTRINSIC_PATHWAY	FGA FGG	2.72e-04	13	27	2	M4470
Pathway	BIOCARTA_EXTRINSIC_PATHWAY	FGA FGG	2.72e-04	13	27	2	MM1395
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	FGA FGG	3.65e-04	15	27	2	M12101
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	FGA FGG	3.65e-04	15	27	2	M1262
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	FGA FGG	3.65e-04	15	27	2	MM14959
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	FGA FGG	3.65e-04	15	27	2	MM14961
Pathway	REACTOME_IRAK4_DEFICIENCY_TLR2_4	FGA FGG	5.30e-04	18	27	2	M27464
Pathway	BIOCARTA_AMI_PATHWAY	FGA FGG	6.57e-04	20	27	2	M15394
Pathway	WP_NETWORK_MAP_OF_SARSCOV2_SIGNALING	FGA AHR ACE2 FGG	7.38e-04	218	27	4	M42569
Pathway	WP_BLOOD_CLOTTING_CASCADE	FGA FGG	7.97e-04	22	27	2	M39480
Pathway	REACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION	FGA FGG	7.97e-04	22	27	2	M17879
Pathway	REACTOME_REGULATION_OF_TLR_BY_ENDOGENOUS_LIGAND	FGA FGG	7.97e-04	22	27	2	M27571
Pathway	REACTOME_REGULATION_OF_TLR_BY_ENDOGENOUS_LIGAND	FGA FGG	7.97e-04	22	27	2	MM15284
Pathway	REACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION	FGA FGG	7.97e-04	22	27	2	MM14558
Pathway	BIOCARTA_INTRINSIC_PATHWAY	FGA FGG	8.72e-04	23	27	2	M15997
Pathway	BIOCARTA_INTRINSIC_PATHWAY	FGA FGG	8.72e-04	23	27	2	MM1427
Pathway	WP_BLOOD_CLOTTING_CASCADE	FGA FGG	8.72e-04	23	27	2	MM15936
Pathway	REACTOME_INTEGRIN_SIGNALING	FGA FGG	1.20e-03	27	27	2	M760
Pathway	REACTOME_INTEGRIN_SIGNALING	FGA FGG	1.29e-03	28	27	2	MM14958
Pathway	PID_INTEGRIN2_PATHWAY	FGA FGG	1.39e-03	29	27	2	M169
Pathway	PID_EPHRINB_REV_PATHWAY	FGA FGG	1.49e-03	30	27	2	M257
Pathway	REACTOME_DISEASES_OF_IMMUNE_SYSTEM	FGA FGG	1.69e-03	32	27	2	M27428
Pathway	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	FGA FGG	2.38e-03	38	27	2	MM15456
Pathway	REACTOME_MAP2K_AND_MAPK_ACTIVATION	FGA FGG	2.51e-03	39	27	2	MM15272
Pathway	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	FGA FGG	2.51e-03	39	27	2	M10735
Pathway	REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE	FGA FGG	2.51e-03	39	27	2	M2844
Pathway	REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE	FGA FGG	2.51e-03	39	27	2	MM14559
Pathway	REACTOME_MAP2K_AND_MAPK_ACTIVATION	FGA FGG	2.63e-03	40	27	2	M27557
Pathway	PID_UPA_UPAR_PATHWAY	FGA FGG	2.90e-03	42	27	2	M174
Pathway	WP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING	FGA FGG	3.04e-03	43	27	2	M39744
Pathway	PID_INTEGRIN3_PATHWAY	FGA FGG	3.04e-03	43	27	2	M53
Pathway	REACTOME_SIGNALING_BY_MODERATE_KINASE_ACTIVITY_BRAF_MUTANTS	FGA FGG	3.32e-03	45	27	2	M27623
Pathway	WP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING_PATHWAY	FGA FGG	3.77e-03	48	27	2	MM15897
Pubmed	Inherited dysfibrinogenemia: clinical phenotypes associated with five different fibrinogen structure defects.	FGA FGG	7.19e-07	2	30	2	19923982
Pubmed	Antibody blockade or mutation of the fibrinogen gamma-chain C-terminus is more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen.	FGA FGG	7.19e-07	2	30	2	14644995
Pubmed	Fibrinogen Milano XII: a dysfunctional variant containing 2 amino acid substitutions, Aalpha R16C and gamma G165R.	FGA FGG	7.19e-07	2	30	2	11435303
Pubmed	Possible Involvement of the Upregulation of ΔNp63 Expression Mediated by HER2-Activated Aryl Hydrocarbon Receptor in Mammosphere Maintenance.	AHR TP63	7.19e-07	2	30	2	36292946
Pubmed	Identification of four novel polymorphisms in the Aalpha and gamma fibrinogen genes and analysis of association with plasma levels of the protein.	FGA FGG	7.19e-07	2	30	2	11562340
Pubmed	Isolation and characterisation of cDNA clones for the A alpha- and gamma-chains of human fibrinogen.	FGA FGG	7.19e-07	2	30	2	6689067
Pubmed	The limits of promiscuity: isoform-specific dimerization of filamins.	FLNB FLNC	7.19e-07	2	30	2	12525170
Pubmed	A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha.	FLNB FLNC	7.19e-07	2	30	2	9694715
Pubmed	Two Novel Heterozygous Mutations (p.γPhe230Val and p.AαAsn839Thr) Cause Hereditary Hypodysfibrinogenemia in Two Chinese Independent Families.	FGA FGG	7.19e-07	2	30	2	36599322
Pubmed	Genetic variation in the fibrinogen-alpha and fibrinogen-gamma genes in relation to arterial stiffness: the Rotterdam Study.	FGA FGG	7.19e-07	2	30	2	19412134
Pubmed	Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: the Rotterdam Study.	FGA FGG	7.19e-07	2	30	2	17264959
Pubmed	Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study.	FGA FGG	7.19e-07	2	30	2	18690352
Pubmed	Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3.	AHR LGR5	7.19e-07	2	30	2	34755534
Pubmed	Quantitative Serum Proteomic Study Reveals that Fibrinogen-Related Proteins May Participate in the Pathophysiological Process of Simple Febrile Convulsion.	FGA FGG	2.16e-06	3	30	2	32126779
Pubmed	Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease.	FGA FGG	2.16e-06	3	30	2	15217804
Pubmed	Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aalpha 9, Leu-->Pro).	FGA FGG	2.16e-06	3	30	2	12706644
Pubmed	Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis.	AHR SCD5	2.16e-06	3	30	2	21890736
Pubmed	Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen gamma' levels.	FGA FGG	2.16e-06	3	30	2	16144795
Pubmed	[Genetic analysis of a Chinese pedigree affected with Congenital dysfibrinogenemia due to variant of FGG gene].	FGA FGG	2.16e-06	3	30	2	37906135
Pubmed	Clinical phenotype, laboratory features and genotype of 35 patients with heritable dysfibrinogenaemia.	FGA FGG	2.16e-06	3	30	2	23061815
Pubmed	Filamins as integrators of cell mechanics and signalling.	FLNB FLNC	2.16e-06	3	30	2	11252955
Pubmed	Covalent structure of single-stranded fibrin oligomers cross-linked by FXIIIa.	FGA FGG	2.16e-06	3	30	2	25896761
Pubmed	Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.	FGA FGG	2.16e-06	3	30	2	10074346
Pubmed	Association study between variants in the fibrinogen gene cluster, fibrinogen levels and hypertension: results from the MONICA/KORA study.	FGA FGG	2.16e-06	3	30	2	19190816
Pubmed	Crystal structure of fragment double-D from human fibrin with two different bound ligands.	FGA FGG	2.16e-06	3	30	2	9628725
Pubmed	Identification and characterization of novel mutations in Chinese patients with congenital fibrinogen disorders.	FGA FGG	2.16e-06	3	30	2	32877852
Pubmed	Local chromatin interactions contribute to expression of the fibrinogen gene cluster.	FGA FGG	2.16e-06	3	30	2	30039577
Pubmed	Two-peaked synchronization in day/night expression rhythms of the fibrinogen gene cluster in the mouse liver.	FGA FGG	2.16e-06	3	30	2	12750384
Pubmed	The role of betagamma and alphagamma complexes in the assembly of human fibrinogen.	FGA FGG	2.16e-06	3	30	2	8910396
Pubmed	Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini.	FGA FGG	2.16e-06	3	30	2	17688324
Pubmed	Correlation of D dimer and factor VIII levels with histopathology in patients with breast carcinoma.	FGA FGG	2.16e-06	3	30	2	21694469
Pubmed	Clinical and biological features of 3 cases of hypofibrinogenemia associated with three different mutations (gamma Ala341Thr, Bbeta Tyr326Cys and Aalpha Asp496Asn).	FGA FGG	2.16e-06	3	30	2	17849064
Pubmed	The association between fibrinogen haplotypes and myocardial infarction in men is partly mediated through pleiotropic effects on the serum IL-6 concentration.	FGA FGG	2.16e-06	3	30	2	17241179
Pubmed	Congenital hypodysfibrinogenemia associated with a novel deletion of three residues (γAla289_Asp291del) in fibrinogen.	FGA FGG	2.16e-06	3	30	2	29748775
Pubmed	Fibrinogen gene variation and ischemic stroke.	FGA FGG	2.16e-06	3	30	2	18331453
Pubmed	Fibrinogen, COPD and mortality in a nationally representative U.S. cohort.	FGA FGG	2.16e-06	3	30	2	22489912
Pubmed	Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer.	FGA FGG	2.16e-06	3	30	2	27738342
Pubmed	The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity.	AHR LGR5	2.16e-06	3	30	2	30119997
Pubmed	Fibrinogen and fibrin.	FGA FGG	2.16e-06	3	30	2	6383194
Pubmed	The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance.	FGA FGG	2.16e-06	3	30	2	16846481
Pubmed	Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction.	FGA FGG	2.16e-06	3	30	2	15735812
Pubmed	gammaAla82Gly represents a common fibrinogen gamma-chain variant in Caucasians.	FGA FGG	2.16e-06	3	30	2	15795540
Pubmed	Association of fibrinogen with severity of stable coronary artery disease in patients with type 2 diabetic mellitus.	FGA FGG	2.16e-06	3	30	2	24803720
Pubmed	Congenital hypofibrinogenemia associated with novel homozygous fibrinogen Aα and heterozygous Bβ chain mutations.	FGA FGG	2.16e-06	3	30	2	25981141
Pubmed	New insights into fibrin (ogen) structure and function.	FGA FGG	2.16e-06	3	30	2	12617173
Pubmed	gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors.	FGA FGG	2.16e-06	3	30	2	6281794
Pubmed	Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study.	FGA FGG	2.16e-06	3	30	2	18772067
Pubmed	Elevated plasma fibrinogen gamma' concentration is associated with myocardial infarction: effects of variation in fibrinogen genes and environmental factors.	FGA FGG	2.16e-06	3	30	2	17263791
Pubmed	Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study.	FGA FGG	2.16e-06	3	30	2	20167083
Pubmed	Quantitative studies on the release of platelet fibrinogen by thrombin.	FGA FGG	2.16e-06	3	30	2	5084810
Pubmed	Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies.	FGA FGG	2.16e-06	3	30	2	19515723
Pubmed	Fibrinogen genes and myocardial infarction: a haplotype analysis.	FGA FGG	2.16e-06	3	30	2	18202324
Pubmed	A central role for intermolecular dityrosine cross-linking of fibrinogen in high molecular weight advanced oxidation protein product (AOPP) formation.	FGA FGG	2.16e-06	3	30	2	25280629
Pubmed	Fibrinogen and fragment D-induced vascular constriction.	FGA FGG	2.16e-06	3	30	2	15739255
Pubmed	Congenital hypofibrinogenemia: characterization of two missense mutations affecting fibrinogen assembly and secretion.	FGA FGG	2.16e-06	3	30	2	18676163
Pubmed	Fibrinogen as a Pleiotropic Protein Causing Human Diseases: The Mutational Burden of Aα, Bβ, and γ Chains.	FGA FGG	2.16e-06	3	30	2	29240685
Pubmed	Fibrinogen gene regulation.	FGA FGG	2.16e-06	3	30	2	22836683
Pubmed	Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications.	FGA FGG	2.16e-06	3	30	2	6575389
Pubmed	Fibrinogen-induced endothelin-1 production from endothelial cells.	FGA FGG	2.16e-06	3	30	2	19193866
Pubmed	Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.	FLNB FLNC	2.16e-06	3	30	2	12393796
Pubmed	Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences.	FGA FGG	2.16e-06	3	30	2	7356959
Pubmed	Reduced thrombin generation increases host susceptibility to group A streptococcal infection.	FGA FGG	2.16e-06	3	30	2	19056689
Pubmed	The chymotrypsin-like protease complex of Treponema denticola ATCC 35405 mediates fibrinogen adherence and degradation.	FGA FGG	2.16e-06	3	30	2	17591786
Pubmed	Polymerization of fibrin: Direct observation and quantification of individual B:b knob-hole interactions.	FGA FGG	2.16e-06	3	30	2	16940416
Pubmed	Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study.	FGA FGG	2.16e-06	3	30	2	16706972
Pubmed	Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.	FGA FGG	2.16e-06	3	30	2	9333233
Pubmed	Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.	FGA FGG	2.16e-06	3	30	2	23187627
Pubmed	The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease.	FGA FGG	2.16e-06	3	30	2	20709368
Pubmed	Fibrinogen.	FGA FGG	2.16e-06	3	30	2	10467729
Pubmed	Clinical and molecular characterization by next generation sequencing of Spanish patients affected by congenital deficiencies of fibrinogen.	FGA FGG	2.16e-06	3	30	2	31295712
Pubmed	Fibrin drives thromboinflammation and neuropathology in COVID-19.	FGA FGG	2.16e-06	3	30	2	39198643
Pubmed	Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.	FLNB FLNC	2.16e-06	3	30	2	11153914
Pubmed	The role of fibrin matrices and tissue factor in early-term trophoblast proliferation and spreading.	FGA FGG	2.16e-06	3	30	2	24041635
Pubmed	Preoperative Serum Fibrinogen is Associated With Acute Kidney Injury after Cardiac Valve Replacement Surgery.	FGA FGG	2.16e-06	3	30	2	32286477
Pubmed	Congenital fibrinogen disorders: an update.	FGA FGG	2.16e-06	3	30	2	23852822
Pubmed	Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway.	FGA FGG	2.16e-06	3	30	2	8100742
Pubmed	Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study.	FGA FGG	2.16e-06	3	30	2	18278190
Pubmed	Haplotypes of the fibrinogen gene and cerebral small vessel disease: the Rotterdam scan study.	FGA FGG	2.16e-06	3	30	2	17951283
Pubmed	Disulfide bridges in nh2 -terminal part of human fibrinogen.	FGA FGG	2.16e-06	3	30	2	936108
Pubmed	2.8 A crystal structures of recombinant fibrinogen fragment D with and without two peptide ligands: GHRP binding to the "b" site disrupts its nearby calcium-binding site.	FGA FGG	2.16e-06	3	30	2	12356313
Pubmed	Diagnostic accuracy of fibrinogen to differentiate appendicitis from nonspecific abdominal pain in children.	FGA FGG	4.31e-06	4	30	2	27760719
Pubmed	Complete antithrombin deficiency in mice results in embryonic lethality.	FGA FGG	4.31e-06	4	30	2	11018075
Pubmed	Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.	FGA FGG	4.31e-06	4	30	2	12218060
Pubmed	Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.	PCM1 HTT	4.31e-06	4	30	2	21985783
Pubmed	Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif.	FGA FGG	4.31e-06	4	30	2	17932565
Pubmed	Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence.	LGR5 TP63	4.31e-06	4	30	2	33159086
Pubmed	Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.	FGA FGG	4.31e-06	4	30	2	37291385
Pubmed	Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival.	FGA FGG	4.31e-06	4	30	2	10903502
Pubmed	PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow.	FGA FGG	4.31e-06	4	30	2	23056168
Pubmed	Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway.	FGA FGG	4.31e-06	4	30	2	18593877
Pubmed	The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.	FLNB FLNC	4.31e-06	4	30	2	11739414
Pubmed	Dermatopontin regulates fibrin formation and its biological activity.	FGA FGG	4.31e-06	4	30	2	23877568
Pubmed	Structural interaction and functional regulation of polycystin-2 by filamin.	FLNB FLNC	4.31e-06	4	30	2	22802962
Pubmed	Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells.	AHR LGR5	4.31e-06	4	30	2	32915464
Pubmed	Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory?	FGA FGG	4.31e-06	4	30	2	27044366
Pubmed	Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor.	FGA FGG	4.31e-06	4	30	2	22381526
Pubmed	Common genetic variants associated with plasma fibrin D-dimer concentration in older European- and African-American adults.	FGA FGG	4.31e-06	4	30	2	18208536
Pubmed	Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection.	FGA FGG	4.31e-06	4	30	2	35041705
Pubmed	Novel prognostic biomarkers of gastric cancer based on gene expression microarray: COL12A1, GSTA3, FGA and FGG.	FGA FGG	4.31e-06	4	30	2	30106150
Pubmed	Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study.	FGA FGG	4.31e-06	4	30	2	20059469
Interaction	ITGB3 interactions	FGA FLNB FLNC FGG HTT	4.84e-06	170	30	5	int:ITGB3
Cytoband	4q28	FGA FGG	1.48e-05	9	30	2	4q28
Cytoband	Ensembl 112 genes in cytogenetic band chr10q23	CPEB3 LIPK	7.22e-03	195	30	2	chr10q23
GeneFamily	WD repeat domain containing	ERCC8 DCAF11 THOC3 CFAP44	1.74e-04	262	20	4	362
GeneFamily	Fibrinogen C domain containing	FGA FGG	3.43e-04	25	20	2	554
GeneFamily	Endogenous ligands	FGA FGG HTT	2.15e-03	237	20	3	542
Coexpression	NABA_MATRISOME_ANGIOGENIC_PANCREATIC_ISLETS	FGA FGG	1.89e-05	6	30	2	MM17052
Coexpression	DAUER_STAT3_TARGETS_UP	FGA FLNB FGG	2.26e-05	48	30	3	M12391
Coexpression	NABA_MATRISOME_INSULINOMA	FGA FGG	2.65e-05	7	30	2	MM17050
Coexpression	ZENG_GU_POST_ICB_METAGENE_39	ACE2 LIPK SCD5 LGR5	8.33e-05	204	30	4	MM17090
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|IPF / Disease state, Lineage and Cell class	ROS1 SCD5 FGD6 TP63	7.28e-06	187	30	4	19d6a404fc3651d98a93e3848e372df51a239c57
ToppCell	LPS-IL1RA-Endothelial-Mes-Like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EXOG THOC3 CFAP44	1.25e-04	145	30	3	90ca38c02325c5c637c32efdef634b54cc3cd105
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGA ERCC8 FGG	1.27e-04	146	30	3	74009a2921359a8352afbaea8c325a3743622543
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGA ERCC8 FGG	1.27e-04	146	30	3	cb19f2bb6832d11fe69b670df49eac096a378a9d
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGA FGG CHRM3	1.44e-04	152	30	3	c21e2152b0130485659051d8fb7fb4589d1ec997
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSL1 THBS2 TP63	1.73e-04	162	30	3	71d7849108a1b59beff40e46000172c45a2f5439
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	AHR FLNB CHRM3	1.76e-04	163	30	3	d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCell	10x5'-blood-Lymphocytic_Invariant-Inducer-like-ILC3\|blood / Manually curated celltypes from each tissue	CPEB3 FGA CHRM3	1.83e-04	165	30	3	f012a27ece54c0f7b73a2f4f89c6ee8b865f8782
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACE2 NSL1 THBS2	1.86e-04	166	30	3	49103b75c3e08656c5774f56fd00d7bd53eefcfb
ToppCell	Basal_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	SCD5 LGR5 TP63	1.86e-04	166	30	3	23c04d1fba0c1733ccd0e4378fae2edde4fd0a7b
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ROS1 CHRM3 HYAL1	1.86e-04	166	30	3	89e2b8453180983533faccb4275867861876d7ee
ToppCell	Basal_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	THBS2 SCD5 TP63	1.93e-04	168	30	3	48089fa2d4a0f31a72405717119b767a92571f01
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB3 SCD5 LGR5	2.07e-04	172	30	3	1565f38266891c3acf49778838de134c5dee5460
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGA FGG LGR5	2.14e-04	174	30	3	e7cca4b6a3935fad61cf2a3d9984ab1ffa1a9447
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGA FGG LGR5	2.14e-04	174	30	3	ad5b56f0ace6455c033834b931ec870cc0dc9290
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 FGD6 CHRM3	2.17e-04	175	30	3	9d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGA FGG LGR5	2.17e-04	175	30	3	6759d200a133034756de9cdf2d5daceca927aac9
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 FGD6 CHRM3	2.17e-04	175	30	3	f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCell	COPD-Epithelial-Aberrant_Basaloid\|World / Disease state, Lineage and Cell class	ROS1 SCD5 TP63	2.25e-04	177	30	3	22b7cda748cf5e665be54ca5bae89f0c130d5e7f
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGA FGG LGR5	2.25e-04	177	30	3	2af09028014f4ec3b7d2a4c286f1ae5e84a9f590
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB3 SCD5 LGR5	2.29e-04	178	30	3	dfed0fbf7a73b8a9e00178ec58dc4592b271c344
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB3 SCD5 LGR5	2.29e-04	178	30	3	4df6218b20c2f076c22346d23260964cc0d73e65
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB THBS2 PLD2	2.32e-04	179	30	3	ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AHR THOC3 TP63	2.44e-04	182	30	3	678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AHR THOC3 TP63	2.44e-04	182	30	3	8d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	AHR ROS1 FGG	2.48e-04	183	30	3	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNC THBS2 LGR5	2.52e-04	184	30	3	7b5678718719020b52e7c2a7bd9797987defd7ff
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNC THBS2 LGR5	2.52e-04	184	30	3	54e5b63f55b8d6eccad53d389ea9c78f991e1414
ToppCell	IPF-Epithelial-ATII\|IPF / Disease state, Lineage and Cell class	AHR ROS1 FGG	2.56e-04	185	30	3	563b4e6d92bb5d77a3829556116a8e99aebac615
ToppCell	IPF-Epithelial-ATII\|World / Disease state, Lineage and Cell class	AHR ROS1 FGG	2.60e-04	186	30	3	6a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	AHR ROS1 SCD5	2.60e-04	186	30	3	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	COPD-Epithelial-Club\|World / Disease state, Lineage and Cell class	AHR ROS1 SCD5	2.60e-04	186	30	3	3006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCell	COPD-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	AHR ROS1 FGG	2.64e-04	187	30	3	030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCell	IPF-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	AHR ROS1 FGG	2.68e-04	188	30	3	5f5fad2773e421760e67dbace23fd1f847a2e1e0
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-naive_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCD5 PCM1 REV1	2.68e-04	188	30	3	e079a3873cf442e98ff41a240c80b80995aace11
ToppCell	COPD-Epithelial-ATII\|COPD / Disease state, Lineage and Cell class	AHR ROS1 FGG	2.68e-04	188	30	3	eb6d79d733b53f64ca615bb777c64ed456866549
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|Epithelial / Disease state, Lineage and Cell class	ROS1 FGD6 TP63	2.72e-04	189	30	3	4178be3292ff4a8a1d8098f638d4b8d15164d2c6
ToppCell	IPF-Epithelial-Club\|IPF / Disease state, Lineage and Cell class	AHR ROS1 SCD5	2.72e-04	189	30	3	f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|World / Disease state, Lineage and Cell class	ROS1 SCD5 TP63	2.72e-04	189	30	3	8030a353473da34ae92429f2d822171a2e94248f
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LGR5 CHRM3 HYAL1	2.77e-04	190	30	3	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	COPD-Epithelial-Club\|COPD / Disease state, Lineage and Cell class	AHR ROS1 SCD5	2.81e-04	191	30	3	c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCell	IPF-Epithelial-Club\|World / Disease state, Lineage and Cell class	AHR ROS1 SCD5	2.81e-04	191	30	3	3c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC THBS2 TP63	2.85e-04	192	30	3	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGA ACE2 FGG	2.94e-04	194	30	3	fcbf9c4f3801ab1a34fcd62c752fabc97fc7bde1
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC THBS2 TP63	3.03e-04	196	30	3	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGA FGG LGR5	3.03e-04	196	30	3	4deaadb9796b907b7480fb7af5ed76ebad240850
ToppCell	AT2_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	FGA FGG TP63	3.08e-04	197	30	3	fd7bdfa6bf5966ebc11fdd13915769429540ddbf
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGA FGG LGR5	3.08e-04	197	30	3	f097e729f515e7945b9482e9f9dbc9536b90f0bb
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FGA ROS1 FGG	3.08e-04	197	30	3	d2a4d7e92e91bcc47a7657da2e5c8a3ad7eb08ad
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Mucous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CPEB3 PLD2 CHRM3	3.12e-04	198	30	3	2ae9564da9913510141994262f3739eb095e0a68
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGA ACE2 FGG	3.12e-04	198	30	3	686d973483d027a3ffa2ad4430ba6e50f3d1378e
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGA ACE2 FGG	3.12e-04	198	30	3	a76366611f3561fc8aca7d62d1f0a0ea2bef7792
ToppCell	background-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	FGA THBS2 FGG	3.12e-04	198	30	3	79f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FLNB FLNC HYAL1	3.17e-04	199	30	3	6a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCell	3'-GW_trimst-1-SmallIntestine\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGA ACE2 FGG	3.17e-04	199	30	3	c4a1e0cf3be867e7cebbd8bd3668bc2df391671b
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar-AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FGA ROS1 FGG	3.22e-04	200	30	3	b535323e18d9fb0dde1e0026df142c831e48c29f
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AHR FLNB FGD6	3.22e-04	200	30	3	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	AHR FLNB HYAL1	3.22e-04	200	30	3	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCell	Biopsy_IPF-Epithelial-KRT5-/KRT17+\|Biopsy_IPF / Sample group, Lineage and Cell type	ROS1 FGD6 TP63	3.22e-04	200	30	3	2fc7a3b3aea711ad3d96fd9513f4b40533056d86
ToppCell	LPS_anti-TNF-Endothelial-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	AHR FLNB HYAL1	3.22e-04	200	30	3	60d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
Drug	AC1L1EW8	FGA ACE2 FGG	3.69e-06	24	29	3	CID000002976
Drug	TA-993	FGA FGG	9.38e-06	4	29	2	CID000129579
Drug	Dabigatran	FGA FGG	9.38e-06	4	29	2	ctd:D000069604
Drug	SC-47643	FGA FGG	9.38e-06	4	29	2	CID000124392
Drug	Sucralfate	FGA FGG	1.56e-05	5	29	2	DB00364
Drug	Smoke	CPEB3 FGA AHR FLNC THBS2 LGR5 FGD6 TP63	1.58e-05	937	29	8	ctd:D012906
Drug	mergetpa	FGA ACE2 FGG	1.92e-05	41	29	3	CID000123726
Drug	lefradafiban	FGA FGG	2.34e-05	6	29	2	CID009576916
Drug	Rgdy	FGA FGG	2.34e-05	6	29	2	CID000129979
Drug	elarofiban	FGA FGG	2.34e-05	6	29	2	CID000216230
Drug	Isopaque Coronar	FGA FGG	2.34e-05	6	29	2	CID000023664
Drug	GR144053	FGA FGG	3.28e-05	7	29	2	CID000173613
Drug	Tolterodine Tartrate	AHR CHRM3	3.28e-05	7	29	2	ctd:D000068737
Drug	Gly-Pro-Arg-Pro-amide	FGA FGG	3.28e-05	7	29	2	CID003884696
Drug	Gly-his-arg	FGA FGG	3.28e-05	7	29	2	CID000133872
Drug	Adenosine Diphosphate	FGA AHR FGG	3.71e-05	51	29	3	ctd:D000244
Drug	AC1L9GAJ	FGA FGG PLD2	3.71e-05	51	29	3	CID000444421
Drug	D00992	FGA FGG HYAL1	3.94e-05	52	29	3	CID011954225
Drug	AC1LCVKH	FGA FGG PLD2	4.17e-05	53	29	3	CID000656813
Drug	Ac-rgds-nh2	FGA FGG	4.37e-05	8	29	2	CID003081210
Drug	Desaa-fibrin	FGA FGG	4.37e-05	8	29	2	CID000127263
Drug	AT-Cdop	FGA FGG	4.37e-05	8	29	2	CID000133604
Drug	xemilofiban	FGA FGG	5.61e-05	9	29	2	CID000060957
Drug	Fibrin	FGA FGG	5.61e-05	9	29	2	CID000439199
Drug	Natamycin	FGA FGG	5.61e-05	9	29	2	ctd:D010866
Drug	AC-474	FGA FLNB FGG	5.76e-05	59	29	3	CID000002999
Drug	Coversyl	FGA ACE2 FGG	6.05e-05	60	29	3	CID000060184
Drug	fenpropathrin	FGA ROS1 FGG	6.68e-05	62	29	3	CID000047326
Drug	HFPA	FGA FGG	7.00e-05	10	29	2	CID003035614
Drug	AC1L1CXL	FGA FGG	7.00e-05	10	29	2	CID000002106
Drug	poly(GEMA	FGA FGG	7.00e-05	10	29	2	CID003083177
Drug	tetraglyme	FGA FGG	7.00e-05	10	29	2	CID000008925
Drug	fradafiban	FGA FGG	7.00e-05	10	29	2	CID000066000
Drug	estradiol valerate-dienogest	FGA FGG	7.00e-05	10	29	2	ctd:C454300
Drug	tranexamic acid	FGA AHR FGG	7.35e-05	64	29	3	CID000005526
Drug	ICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A_EA	FLNB PCM1 HTT REV1	8.02e-05	182	29	4	1043_DN
Drug	Benzophenanthridines	FGA AHR FGG	8.43e-05	67	29	3	ctd:D053119
Drug	dicentrine	FGA FGG	8.55e-05	11	29	2	CID000101300
Drug	indolo(3,2-b)carbazole	FGA AHR FGG	9.20e-05	69	29	3	ctd:C075954
Drug	Fluvastatin sodium salt [93957-55-2]; Down 200; 9.2uM; PC3; HT_HG-U133A	DCAF11 SCD5 LGR5 HTT	1.01e-04	193	29	4	6691_DN
Drug	Rgh 2958	FGA FGG	1.03e-04	12	29	2	CID000124710
Drug	etofibrate	FGA FGG	1.03e-04	12	29	2	CID000065777
Drug	Arg-tyr-asp	FGA FGG	1.03e-04	12	29	2	CID000131136
Drug	Leucokinin I	ACE2 TP63	1.03e-04	12	29	2	CID005491285
Drug	CP-645525-01 [287190-82-3]; Up 200; 10uM; MCF7; HT_HG-U133A	ERCC8 PLD2 FGD6 PCM1	1.03e-04	194	29	4	7522_UP
Drug	Cefamandole sodium salt [30034-03-8]; Up 200; 8.2uM; MCF7; HT_HG-U133A	EXOG PLD2 CHRM3 PCM1	1.07e-04	196	29	4	4718_UP
Drug	Ifenprodil tartrate [23210-58-4]; Down 200; 8.4uM; PC3; HT_HG-U133A	EXOG DCAF11 LGR5 PCM1	1.09e-04	197	29	4	5044_DN
Drug	Lansoprazole [103577-45-3]; Down 200; 10.8uM; MCF7; HT_HG-U133A	FLNC SCD5 CFAP44 CHRM3	1.09e-04	197	29	4	3529_DN
Drug	Naringenine [480-41-1]; Down 200; 14.6uM; HL60; HT_HG-U133A	ERCC8 FLNB PCM1 HTT	1.09e-04	197	29	4	1342_DN
Drug	Methylhydantoin-5-(D) [55147-68-7]; Down 200; 35uM; PC3; HT_HG-U133A	ERCC8 DCAF11 LGR5 PCM1	1.13e-04	199	29	4	3994_DN
Drug	estradiol, USP; Down 200; 0.01uM; PC3; HG-U133A	FGA FGD6 TP63 HTT	1.16e-04	200	29	4	665_DN
Drug	AC1LCWCV	FGA FGG	1.21e-04	13	29	2	CID000657319
Drug	Ro 48-3657	FGA FGG	1.21e-04	13	29	2	CID005491394
Drug	N-benzylformamide	AHR ACE2 THBS2	1.23e-04	76	29	3	CID000080654
Drug	Benazepril-d5	FGA ACE2 FGG	1.28e-04	77	29	3	CID000002311
Drug	C4 m	FGA FGG TP63	1.38e-04	79	29	3	CID009543487
Drug	Rgdf peptide	FGA FGG	1.41e-04	14	29	2	CID003080994
Drug	lotrafiban	FGA FGG	1.41e-04	14	29	2	CID000080274
Drug	acetal	FLNB HTT	1.41e-04	14	29	2	CID000007765
Drug	Ro 435054	FGA FGG	1.41e-04	14	29	2	CID000132121
Drug	FK-633	FGA FGG	1.41e-04	14	29	2	CID000132814
Drug	Levonorgestrel	CPEB3 FGA ACE2 FGG	1.53e-04	215	29	4	ctd:D016912
Drug	NSC-270916	FGA AHR FGG	1.54e-04	82	29	3	CID000002949
Drug	S 2441	FGA FGG	1.63e-04	15	29	2	CID000133194
Drug	Dmp 728	FGA FGG	1.63e-04	15	29	2	CID000121844
Drug	Mk 0852	FGA FGG	1.86e-04	16	29	2	CID000164406
Drug	Chromozym Th	FGA FGG	1.86e-04	16	29	2	CID000123649
Drug	Gly-his-arg-pro	FGA FGG	1.86e-04	16	29	2	CID000128928
Drug	AC1OCA8A	FGA FGG LGR5	1.96e-04	89	29	3	CID006914573
Drug	olmesartan	FGA ACE2 FGG	2.09e-04	91	29	3	CID000158781
Drug	hexonate	AHR HTT	2.11e-04	17	29	2	CID000199748
Drug	fluorenone	FLNB TP63	2.11e-04	17	29	2	CID000010241
Drug	diflubenzuron	AHR THOC3	2.37e-04	18	29	2	CID000037123
Drug	AC1L3X9U	FGA FGG	2.37e-04	18	29	2	CID000096811
Drug	Biomer	FGA FGG	2.37e-04	18	29	2	CID003085227
Drug	manidipine	FGA ACE2 FGG	2.38e-04	95	29	3	CID000004008
Drug	telmisartan	FGA ACE2 FGG	2.45e-04	96	29	3	CID000065999
Drug	AC1L4UXD	FGA FGG	2.64e-04	19	29	2	CID000164519
Drug	Chir 99021	AHR LGR5	2.64e-04	19	29	2	ctd:C473711
Drug	3-bp	FGA HTT	2.64e-04	19	29	2	CID005326878
Drug	2-methacryloyloxyethyl phosphorylcholine	FGA FGG	2.64e-04	19	29	2	CID000128934
Drug	norgestimate	FGA FGG	2.64e-04	19	29	2	ctd:C017576
Drug	Zithromac	FGA FGG TP63	2.68e-04	99	29	3	CID000002269
Drug	S 2160	FGA FGG	2.93e-04	20	29	2	CID000189147
Drug	roxifiban	FGA FGG	2.93e-04	20	29	2	CID000164518
Drug	K-76COOH	FGA FGG	3.24e-04	21	29	2	CID000119528
Drug	iodine monochloride	FGA FGG	3.24e-04	21	29	2	CID000024640
Drug	tetraphenylporphyrin	LGR5 TP63	3.24e-04	21	29	2	CID000070186
Drug	Rgds Peptide	FGA THBS2 FGG	3.28e-04	106	29	3	CID000107775
Drug	R-TB	EXOG REV1	3.56e-04	22	29	2	CID000446589
Drug	zirconium	AHR LGR5 HYAL1	3.76e-04	111	29	3	CID000023995
Drug	Ex-PRESS	AHR EXOG	3.90e-04	23	29	2	CID000153909
Drug	Rges Peptide	FGA FGG	3.90e-04	23	29	2	CID000121927
Drug	AC1Q6CTU	FGA ACE2 FGG	4.49e-04	118	29	3	CID000021362
Drug	Paraoxon	AHR SCD5 CHRM3	4.61e-04	119	29	3	ctd:D010261
Drug	APPT	FGA FGG	4.61e-04	25	29	2	CID000124311
Drug	hydrochlorothiazide	FGA ACE2 FGG	4.72e-04	120	29	3	CID000003639
Drug	Dactinomycin	AHR FLNC ROS1 PLD2	4.76e-04	290	29	4	ctd:D003609
Drug	atenolol	FGA ACE2 FGG	4.95e-04	122	29	3	CID000002249
Drug	Gestodene	FGA FGG	5.00e-04	26	29	2	ctd:C033273
Disease	congenital afibrinogenemia (implicated_via_orthology)	FGA FGG	9.99e-07	2	30	2	DOID:2236 (implicated_via_orthology)
Disease	brain small vessel disease (is_implicated_in)	FGA FGG	3.00e-06	3	30	2	DOID:0112313 (is_implicated_in)
Disease	Hereditary factor I deficiency disease	FGA FGG	3.00e-06	3	30	2	cv:C0019250
Disease	DYSFIBRINOGENEMIA, CONGENITAL	FGA FGG	3.00e-06	3	30	2	616004
Disease	Familial dysfibrinogenemia	FGA FGG	3.00e-06	3	30	2	cv:C0272350
Disease	congenital afibrinogenemia (is_implicated_in)	FGA FGG	3.00e-06	3	30	2	DOID:2236 (is_implicated_in)
Disease	distal muscular dystrophy 4 (implicated_via_orthology)	FLNB FLNC	3.00e-06	3	30	2	DOID:0111190 (implicated_via_orthology)
Disease	myofibrillar myopathy 5 (implicated_via_orthology)	FLNB FLNC	3.00e-06	3	30	2	DOID:0080096 (implicated_via_orthology)
Disease	Dysfibrinogenemia, Congenital	FGA FGG	3.00e-06	3	30	2	C0272350
Disease	Congenital afibrinogenemia	FGA FGG	3.00e-06	3	30	2	cv:C2584774
Disease	AFIBRINOGENEMIA, CONGENITAL	FGA FGG	3.00e-06	3	30	2	202400
Disease	Afibrinogenemia	FGA FGG	5.99e-06	4	30	2	C0001733
Disease	Congenital hypofibrinogenemia	FGA FGG	5.99e-06	4	30	2	C2584774
Disease	Fibrinogen Deficiency	FGA FGG	9.97e-06	5	30	2	C4316812
Disease	pulmonary embolism (biomarker_via_orthology)	FGA FGG	6.55e-05	12	30	2	DOID:9477 (biomarker_via_orthology)
Disease	pulmonary embolism	FGA FGG	2.95e-04	25	30	2	EFO_0003827
Disease	longevity, healthspan, parental longevity	FGD6 HTT	3.99e-04	29	30	2	EFO_0004300, EFO_0007796, EFO_0009762
Disease	D dimer measurement	FGA FGG	4.27e-04	30	30	2	EFO_0004507
Disease	cutaneous squamous cell carcinoma	AHR TP63	5.17e-04	33	30	2	EFO_1001927
Disease	pancreatitis (biomarker_via_orthology)	FGA FGG	7.23e-04	39	30	2	DOID:4989 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FNESMNECRNWQDNT	AHR	486	P35869
QMDQDHSSSDSWNNN	CHRM3	326	P20309
MNETGNNFWLAQDAN	CFAP44	431	Q96MT7
NGQAWQEASDNCFMD	NSL1	91	Q96IY1
MSSDNQWSADEDEGQ	HIGD1C	1	A8MV81
DNAREAMQQADDWLG	FLNB	196	O75369
SNENVDDRLNNMDWG	PCM1	21	Q15154
EGMEASRQAATQQNW	DCAF11	391	Q8TEB1
ENAREAMQQADDWLG	FLNC	216	Q14315
DAADANNGAQDDMNW	MARCHF6	246	O60337
QDFDNNSGYWNRIEM	EXOG	166	Q9Y2C4
DNRMRLWNSSNGENT	ERCC8	266	Q13216
DEWNDFNFDMDARRN	TP63	656	Q9H3D4
TSHNGMQFSTWDNDN	FGG	331	P02679
RNMVQAEQENDTSGW	HTT	1376	P42858
SWMEDNAFRTDNGNN	CPEB3	316	Q8NE35
EENVQNMNNAGDKWS	ACE2	56	Q9BYF1
NNMQFSTFDRDADQW	FGA	781	P02671
AQDQFQGAARAWMAG	HYAL1	171	Q12794
ISNQWNKGDNSSMDD	LGR5	491	O75473
NNMGAWRDHDDSAFT	POTEA	41	Q6S8J7
DNEWNYTRAGQAFTM	NXF2	596	Q9GZY0
NSMAFQNDIFEWSRD	SCD5	116	Q86SK9
MNSWNEEDENNDFSF	REV1	186	Q9UBZ9
EWQNSSSMEDADANV	FGD6	776	Q6ZV73
NEISWNNDNNMFFLT	THOC3	186	Q96J01
SSDIGNVSDMDWYNN	ROS1	701	P08922
NMSACWQDGRFFAEN	THBS2	316	P35442
DFFQLWQDMAESNAN	PLD2	841	O14939
GQLQAFDWGNSDQNM	LIPK	301	Q5VXJ0