Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionIMP dehydrogenase activity

IMPDH1 IMPDH2

8.01e-062572GO:0003938
GeneOntologyMolecularFunctionprotein serine/threonine kinase inhibitor activity

DEPTOR PRKAR1A PRKAR1B

2.18e-0441573GO:0030291
GeneOntologyMolecularFunctioncAMP-dependent protein kinase inhibitor activity

PRKAR1A PRKAR1B

3.55e-0410572GO:0004862
GeneOntologyMolecularFunctioncAMP-dependent protein kinase regulator activity

PRKAR1A PRKAR1B

6.12e-0413572GO:0008603
GeneOntologyBiologicalProcesspurine ribonucleotide salvage

IMPDH1 IMPDH2 GMPR

9.27e-0616543GO:0106380
GeneOntologyBiologicalProcesspurine nucleotide salvage

IMPDH1 IMPDH2 GMPR

1.60e-0519543GO:0032261
GeneOntologyBiologicalProcesspurine-containing compound salvage

IMPDH1 IMPDH2 GMPR

2.52e-0522543GO:0043101
GeneOntologyBiologicalProcesspurine ribonucleoside monophosphate biosynthetic process

IMPDH1 IMPDH2 GMPR

2.89e-0523543GO:0009168
GeneOntologyBiologicalProcesspurine nucleoside monophosphate biosynthetic process

IMPDH1 IMPDH2 GMPR

3.75e-0525543GO:0009127
GeneOntologyBiologicalProcessnucleotide salvage

IMPDH1 IMPDH2 GMPR

4.23e-0526543GO:0043173
GeneOntologyBiologicalProcessnegative regulation of cAMP/PKA signal transduction

PRKAR1A PRKAR1B

6.69e-055542GO:0141162
GeneOntologyBiologicalProcessribonucleoside monophosphate biosynthetic process

IMPDH1 IMPDH2 GMPR

1.34e-0438543GO:0009156
GeneOntologyBiologicalProcesscellular metabolic compound salvage

IMPDH1 IMPDH2 GMPR

1.56e-0440543GO:0043094
GeneOntologyBiologicalProcessnegative regulation of cAMP-dependent protein kinase activity

PRKAR1A PRKAR1B

1.86e-048542GO:2000480
GeneOntologyBiologicalProcessregulation of cAMP/PKA signal transduction

PRKAR1A PRKAR1B

1.86e-048542GO:0141161
GeneOntologyBiologicalProcessXMP metabolic process

IMPDH1 IMPDH2

1.86e-048542GO:0097292
GeneOntologyBiologicalProcess'de novo' XMP biosynthetic process

IMPDH1 IMPDH2

1.86e-048542GO:0097294
GeneOntologyBiologicalProcessXMP biosynthetic process

IMPDH1 IMPDH2

1.86e-048542GO:0097293
GeneOntologyBiologicalProcesspurine ribonucleoside monophosphate metabolic process

IMPDH1 IMPDH2 GMPR

2.70e-0448543GO:0009167
GeneOntologyBiologicalProcessnucleoside monophosphate biosynthetic process

IMPDH1 IMPDH2 GMPR

2.87e-0449543GO:0009124
GeneOntologyBiologicalProcesscAMP/PKA signal transduction

PRKAR1A PRKAR1B

2.99e-0410542GO:0141156
GeneOntologyBiologicalProcessGMP salvage

IMPDH1 IMPDH2

2.99e-0410542GO:0032263
GeneOntologyBiologicalProcesspurine nucleoside monophosphate metabolic process

IMPDH1 IMPDH2 GMPR

3.23e-0451543GO:0009126
GeneOntologyBiologicalProcesspurine ribonucleotide biosynthetic process

ATP6V1A IMPDH1 IMPDH2 GMPR ADCY7

3.48e-04232545GO:0009152
GeneOntologyBiologicalProcessskeletal myofibril assembly

MYH11 PROX1

3.64e-0411542GO:0014866
GeneOntologyBiologicalProcessresponse to retinoic acid

ABCA1 TRIML2 BRINP1 TEK

3.84e-04131544GO:0032526
GeneOntologyBiologicalProcessribonucleotide biosynthetic process

ATP6V1A IMPDH1 IMPDH2 GMPR ADCY7

4.64e-04247545GO:0009260
GeneOntologyBiologicalProcessGTP biosynthetic process

IMPDH1 IMPDH2

5.15e-0413542GO:0006183
GeneOntologyBiologicalProcessribose phosphate biosynthetic process

ATP6V1A IMPDH1 IMPDH2 GMPR ADCY7

5.17e-04253545GO:0046390
GeneOntologyBiologicalProcessribonucleoside monophosphate metabolic process

IMPDH1 IMPDH2 GMPR

7.22e-0467543GO:0009161
GeneOntologyBiologicalProcessGMP biosynthetic process

IMPDH1 IMPDH2

7.89e-0416542GO:0006177
GeneOntologyBiologicalProcessregulation of cAMP-dependent protein kinase activity

PRKAR1A PRKAR1B

7.89e-0416542GO:2000479
GeneOntologyBiologicalProcesspurine nucleotide biosynthetic process

ATP6V1A IMPDH1 IMPDH2 GMPR ADCY7

8.17e-04280545GO:0006164
GeneOntologyBiologicalProcesspurine-containing compound biosynthetic process

ATP6V1A IMPDH1 IMPDH2 GMPR ADCY7

9.27e-04288545GO:0072522
HumanPhenoCarotid artery stenosis

ABCA1 MYH11 HTRA1

2.42e-067223HP:0100546
DomainIMPDH

IMPDH1 IMPDH2 GMPR

1.08e-074573PF00478
DomainIMP_DH_GMPRt

IMPDH1 IMPDH2 GMPR

1.08e-074573IPR001093
DomainIMP_DH_GMP_RED

IMPDH1 IMPDH2 GMPR

1.08e-074573PS00487
DomainIMP_DH/GMP_Rdtase_CS

IMPDH1 IMPDH2 GMPR

1.08e-074573IPR015875
DomainIMP_DH

IMPDH1 IMPDH2

9.15e-062572IPR005990
DomaincAMP_dep_PK_reg_su

PRKAR1A PRKAR1B

5.47e-054572IPR012198
DomainRIIa

PRKAR1A PRKAR1B

1.36e-046572SM00394
DomainRIIa

PRKAR1A PRKAR1B

1.90e-047572PF02197
Domain-

IMPDH1 IMPDH2 GMPR

2.84e-04425733.20.20.70
DomainAldolase_TIM

IMPDH1 IMPDH2 GMPR

3.27e-0444573IPR013785
DomaincAMP_dep_PK_reg_su_I/II_a/b

PRKAR1A PRKAR1B

9.37e-0415572IPR003117
DomainCBS

IMPDH1 IMPDH2

1.07e-0316572SM00116
DomaincNMP-bd_CS

PRKAR1A PRKAR1B

1.07e-0316572IPR018488
DomainCBS_dom

IMPDH1 IMPDH2

1.68e-0320572IPR000644
DomainCBS

IMPDH1 IMPDH2

1.68e-0320572PF00571
DomainCBS

IMPDH1 IMPDH2

1.68e-0320572PS51371
DomainDAPIN

NLRP7 NLRP4

2.03e-0322572PS50824
DomainPYRIN

NLRP7 NLRP4

2.03e-0322572PF02758
DomainDAPIN

NLRP7 NLRP4

2.03e-0322572IPR004020
DomainPYRIN

NLRP7 NLRP4

2.03e-0322572SM01289
DomainNACHT

NLRP7 NLRP4

2.22e-0323572PS50837
DomainNACHT_NTPase

NLRP7 NLRP4

2.22e-0323572IPR007111
DomainP-loop_NTPase

DHX15 ARHGAP5 ATP6V1A ABCA1 MYH11 ERCC6 NLRP7 NLRP4

4.02e-03848578IPR027417
DomainCNMP_BINDING_1

PRKAR1A PRKAR1B

4.28e-0332572PS00888
DomainCNMP_BINDING_2

PRKAR1A PRKAR1B

4.28e-0332572PS00889
DomaincNMP

PRKAR1A PRKAR1B

4.82e-0334572SM00100
DomaincNMP_binding

PRKAR1A PRKAR1B

4.82e-0334572PF00027
DomaincNMP-bd_dom

PRKAR1A PRKAR1B

5.10e-0335572IPR000595
DomainCNMP_BINDING_3

PRKAR1A PRKAR1B

5.10e-0335572PS50042
DomainBROMODOMAIN_1

BRD3 BRWD3

5.69e-0337572PS00633
DomaincNMP-bd-like

PRKAR1A PRKAR1B

6.00e-0338572IPR018490
DomainBromodomain

BRD3 BRWD3

6.00e-0338572PF00439
PathwayREACTOME_DAG_AND_IP3_SIGNALING

PRKAR1A PRKAR1B ADCY7 ITPR2

7.68e-0641444M512
PathwayREACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB

PRKAR1A PRKAR1B ADCY7

1.54e-0516443MM14492
PathwayREACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING

PRKAR1A PRKAR1B ADCY7

1.87e-0517443M26995
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

PRKAR1A PRKAR1B ADCY7 ITPR2

2.33e-0554444M26911
PathwayREACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB

PRKAR1A PRKAR1B ADCY7

3.12e-0520443M759
PathwayREACTOME_CA_DEPENDENT_EVENTS

PRKAR1A PRKAR1B ADCY7

7.02e-0526443MM14495
PathwayWP_CANNABINOID_RECEPTOR_SIGNALING

PRKAR1A PRKAR1B ADCY7

9.80e-0529443M39676
PathwayREACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION

PRKAR1A PRKAR1B

1.42e-046442MM14628
PathwayREACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION

PRKAR1A PRKAR1B ADCY7

1.45e-0433443M11575
PathwayREACTOME_OPIOID_SIGNALLING

PRKAR1A PRKAR1B ADCY7 ITPR2

1.73e-0490444M6467
PathwayKEGG_MEDICUS_REFERENCE_PKA_HOLOENZYME

PRKAR1A PRKAR1B

1.98e-047442M47896
PathwayREACTOME_CA_DEPENDENT_EVENTS

PRKAR1A PRKAR1B ADCY7

2.05e-0437443M749
PathwayREACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS

PRKAR1A PRKAR1B ADCY7 ITPR2

2.14e-0495444M29842
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

PRKAR1A PRKAR1B ADCY7

2.40e-0439443MM14496
PathwayWP_EPAC1_AND_PKA_REDUCTION_OF_RETINAL_INFLAMMATION

PRKAR1A PRKAR1B

2.63e-048442M48325
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

PRKAR1A PRKAR1B ITPR2

2.99e-0442443M791
PathwayREACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION

PRKAR1A PRKAR1B ADCY7

3.21e-0443443M29837
PathwayREACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS

PRKAR1A PRKAR1B ADCY7

3.21e-0443443M933
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

PRKAR1A PRKAR1B ADCY7 ITPR2

3.49e-04108444M17034
PathwayREACTOME_GPER1_SIGNALING

PRKAR1A PRKAR1B ADCY7

3.67e-0445443M45008
PathwayBIOCARTA_AGPCR_PATHWAY

PRKAR1A PRKAR1B

4.22e-0410442MM1352
PathwayBIOCARTA_CHREBP_PATHWAY

PRKAR1A PRKAR1B

4.22e-0410442MM1530
PathwayBIOCARTA_CFTR_PATHWAY

PRKAR1A PRKAR1B

4.22e-0410442MM1377
PathwayBIOCARTA_PLCE_PATHWAY

PRKAR1A PRKAR1B

5.14e-0411442MM1455
PathwayBIOCARTA_CARM1_PATHWAY

PRKAR1A PRKAR1B

5.14e-0411442MM1521
PathwayBIOCARTA_CFTR_PATHWAY

PRKAR1A PRKAR1B

5.14e-0411442M12399
PathwayBIOCARTA_PLCE_PATHWAY

PRKAR1A PRKAR1B

5.14e-0411442M5576
PathwayBIOCARTA_AGPCR_PATHWAY

PRKAR1A PRKAR1B

5.14e-0411442M19829
PathwayREACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS

IMPDH1 IMPDH2

5.14e-0411442M2071
PathwayREACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS

IMPDH1 IMPDH2

5.14e-0411442MM15425
PathwayWP_HIPPOMERLIN_SIGNALING_DYSREGULATION

PRKAR1A PRKAR1B ITGAD TEK

5.38e-04121444M39823
PathwayREACTOME_AQUAPORIN_MEDIATED_TRANSPORT

PRKAR1A PRKAR1B ADCY7

5.64e-0452443M920
PathwayREACTOME_LEISHMANIA_INFECTION

PRKAR1A PRKAR1B ADCY7 ELMO1 ITPR2

5.73e-04219445M29836
PathwayBIOCARTA_DREAM_PATHWAY

PRKAR1A PRKAR1B

6.16e-0412442MM1475
PathwayBIOCARTA_CARM1_PATHWAY

PRKAR1A PRKAR1B

6.16e-0412442M7968
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_ADENYLATE_CYCLASE

PRKAR1A PRKAR1B

6.16e-0412442M27363
PathwayBIOCARTA_DREAM_PATHWAY

PRKAR1A PRKAR1B

7.27e-0413442M18899
PathwayREACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION

PRKAR1A PRKAR1B ADCY7 ITPR2

7.89e-04134444M29840
PathwayREACTOME_NUCLEOTIDE_BIOSYNTHESIS

IMPDH1 IMPDH2

8.46e-0414442M27830
PathwayBIOCARTA_GATA3_PATHWAY

PRKAR1A PRKAR1B

8.46e-0414442MM1402
PathwayBIOCARTA_GATA3_PATHWAY

PRKAR1A PRKAR1B

8.46e-0414442M1394
PathwayREACTOME_NUCLEOTIDE_BIOSYNTHESIS

IMPDH1 IMPDH2

8.46e-0414442MM15551
PathwayBIOCARTA_CK1_PATHWAY

PRKAR1A PRKAR1B

9.74e-0415442MM1468
PathwayREACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS

PRKAR1A PRKAR1B

9.74e-0415442MM15103
PathwayBIOCARTA_SHH_PATHWAY

PRKAR1A PRKAR1B

9.74e-0415442MM1498
PathwayBIOCARTA_CSK_PATHWAY

PRKAR1A PRKAR1B

1.11e-0316442MM1340
PathwayBIOCARTA_CK1_PATHWAY

PRKAR1A PRKAR1B

1.11e-0316442M16626
PathwayREACTOME_DARPP_32_EVENTS

PRKAR1A PRKAR1B

1.11e-0316442MM14699
PathwayBIOCARTA_SHH_PATHWAY

PRKAR1A PRKAR1B

1.11e-0316442M11792
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

PRKAR1A PRKAR1B ADCY7 ITPR2

1.11e-03147444MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

PRKAR1A PRKAR1B ADCY7 ITPR2

1.23e-03151444M39329
PathwayWP_METABOLIC_PATHWAY_OF_LDL_HDL_AND_TG_INCLUDING_DISEASES

ABCA1 APOB

1.26e-0317442M39747
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY

ABCA1 APOB

1.26e-0317442MM15561
PathwayREACTOME_RHOB_GTPASE_CYCLE

STK10 ARHGAP5 ABR

1.29e-0369443MM15596
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

PRKAR1A PRKAR1B ADCY7 ITPR2

1.32e-03154444MM15974
PathwayREACTOME_RHOB_GTPASE_CYCLE

STK10 ARHGAP5 ABR

1.34e-0370443M41806
PathwayREACTOME_RHOC_GTPASE_CYCLE

STK10 ARHGAP5 ABR

1.34e-0370443MM15597
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

PRKAR1A PRKAR1B ADCY7 ITPR2

1.39e-03156444M39475
PathwayREACTOME_OPIOID_SIGNALLING

PRKAR1A PRKAR1B ADCY7

1.40e-0371443MM14491
PathwayBIOCARTA_MPR_PATHWAY

PRKAR1A PRKAR1B

1.41e-0318442MM1407
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

PRKAR1A PRKAR1B ITPR2

1.46e-0372443MM14631
PathwayKEGG_PURINE_METABOLISM

IMPDH1 IMPDH2 GMPR ADCY7

1.49e-03159444M14314
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY

ABCA1 APOB

1.57e-0319442M27841
PathwayBIOCARTA_MCALPAIN_PATHWAY

PRKAR1A PRKAR1B

1.57e-0319442MM1434
PathwayBIOCARTA_STATHMIN_PATHWAY

PRKAR1A PRKAR1B

1.57e-0319442MM1502
PathwayBIOCARTA_MCALPAIN_PATHWAY

PRKAR1A PRKAR1B

1.57e-0319442M8719
PathwayBIOCARTA_CHREBP_PATHWAY

PRKAR1A PRKAR1B

1.57e-0319442M22004
PathwayREACTOME_RHOC_GTPASE_CYCLE

STK10 ARHGAP5 ABR

1.58e-0374443M41807
PathwayBIOCARTA_NOS1_PATHWAY

PRKAR1A PRKAR1B

1.75e-0320442MM1445
PathwayBIOCARTA_STATHMIN_PATHWAY

PRKAR1A PRKAR1B

1.75e-0320442M16966
PathwayBIOCARTA_CREB_PATHWAY

PRKAR1A PRKAR1B

1.75e-0320442MM1520
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

PRKAR1A PRKAR1B ITPR2

1.83e-0378443M1921
PathwayBIOCARTA_NOS1_PATHWAY

PRKAR1A PRKAR1B

1.93e-0321442M11650
PathwayBIOCARTA_MPR_PATHWAY

PRKAR1A PRKAR1B

1.93e-0321442M13883
PathwayWP_PURINE_METABOLISM

IMPDH1 IMPDH2 GMPR ADCY7

1.94e-03171444MM15909
PathwayBIOCARTA_IGF1R_PATHWAY

PRKAR1A PRKAR1B

2.11e-0322442MM1438
PathwayBIOCARTA_CSK_PATHWAY

PRKAR1A PRKAR1B

2.11e-0322442M6327
PathwayBIOCARTA_CREB_PATHWAY

PRKAR1A PRKAR1B

2.11e-0322442M9070
PathwayREACTOME_AZATHIOPRINE_ADME

IMPDH1 IMPDH2

2.31e-0323442M45013
PathwayBIOCARTA_IGF1R_PATHWAY

PRKAR1A PRKAR1B

2.31e-0323442M19613
PathwayBIOCARTA_BAD_PATHWAY

PRKAR1A PRKAR1B

2.52e-0324442MM1467
PathwayREACTOME_DARPP_32_EVENTS

PRKAR1A PRKAR1B

2.52e-0324442M751
PathwayBIOCARTA_VIP_PATHWAY

PRKAR1A PRKAR1B

2.73e-0325442MM1441
PathwayBIOCARTA_BAD_PATHWAY

PRKAR1A PRKAR1B

2.73e-0325442M85
PathwayWP_G_PROTEIN_SIGNALING_PATHWAYS

PRKAR1A PRKAR1B ADCY7

2.76e-0390443MM15882
PathwayWP_G_PROTEIN_SIGNALING

PRKAR1A PRKAR1B ADCY7

2.85e-0391443M39426
PathwayBIOCARTA_VIP_PATHWAY

PRKAR1A PRKAR1B

2.95e-0326442M17941
PathwayREACTOME_GPER1_SIGNALING

PRKAR1A PRKAR1B

3.18e-0327442MM15664
PathwayREACTOME_AZATHIOPRINE_ADME

IMPDH1 IMPDH2

3.18e-0327442MM15693
PathwayREACTOME_METABOLISM_OF_NUCLEOTIDES

IMPDH1 IMPDH2 GMPR

3.41e-0397443MM14607
PathwayREACTOME_METABOLISM_OF_NUCLEOTIDES

IMPDH1 IMPDH2 GMPR

3.41e-0397443M777
PathwayBIOCARTA_NO1_PATHWAY

PRKAR1A PRKAR1B

3.42e-0328442M4383
PathwayWP_HIPPO_SIGNALING_REGULATION

PRKAR1A PRKAR1B TEK

3.51e-0398443M39830
PathwayWP_LIPID_METABOLISM_PATHWAY

PRKAR1A PRKAR1B

3.66e-0329442M39762
PathwayBIOCARTA_GPCR_PATHWAY

PRKAR1A PRKAR1B

3.66e-0329442MM1495
PathwayBIOCARTA_GPCR_PATHWAY

PRKAR1A PRKAR1B

3.92e-0330442M9664
PathwayREACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS

PRKAR1A PRKAR1B

4.18e-0331442MM15094
PathwayWP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION

ABCA1 APOB

4.18e-0331442M39514
PathwayREACTOME_HEDGEHOG_OFF_STATE

PRKAR1A PRKAR1B ADCY7

4.26e-03105443MM15206
PathwayPID_INTEGRIN_A4B1_PATHWAY

PRKAR1A PRKAR1B

4.73e-0333442M277
Pubmed

cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.

PRKAR1A PRKAR1B ADCY7

1.87e-06155732165385
Pubmed

Expression of IMPDH mRNA after mycophenolate administration in male volunteers.

IMPDH1 IMPDH2

2.64e-06257225105143
Pubmed

Promoter for the regulatory type I beta subunit of the 3',5'-cyclic adenosine monophosphate-dependent protein kinase directs transgene expression in the central nervous system.

PRKAR1A PRKAR1B

2.64e-0625721448119
Pubmed

Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics.

IMPDH1 IMPDH2

2.64e-06257220718729
Pubmed

Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo.

IMPDH1 IMPDH2

2.64e-06257214766016
Pubmed

The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary study.

ABCA1 SNTB1

2.64e-06257216192292
Pubmed

A novel Arabidopsis gene causes Bax-like lethality in Saccharomyces cerevisiae.

ABCA1 SNTB1

2.64e-06257216192270
Pubmed

Two distinct cDNAs for human IMP dehydrogenase.

IMPDH1 IMPDH2

2.64e-0625721969416
Pubmed

Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene.

IMPDH1 IMPDH2

2.64e-0625727896827
Pubmed

Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium.

ABCA1 APOB

2.64e-06257230076206
Pubmed

Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil.

IMPDH1 IMPDH2

2.64e-06257220679962
Pubmed

Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.

ABCA1 APOB

2.64e-06257228694219
Pubmed

Expression of inosine monophosphate dehydrogenase type I and type II after mycophenolate mofetil treatment: a 2-year follow-up in kidney transplantation.

IMPDH1 IMPDH2

2.64e-06257217713475
Pubmed

Mutants of purine metabolism in cultured mouse and hamster cells.

IMPDH1 IMPDH2

2.64e-062572988789
Pubmed

Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.

IMPDH1 IMPDH2

2.64e-06257212944494
Pubmed

Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes.

PRKAR1A PRKAR1B

2.64e-0625728407966
Pubmed

Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs.

IMPDH1 IMPDH2

2.64e-0625722902093
Pubmed

Characterization of human type I and type II IMP dehydrogenases.

IMPDH1 IMPDH2

2.64e-0625727903306
Pubmed

Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding.

IMPDH1 IMPDH2

2.64e-0625727763314
Pubmed

c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.

IMPDH1 IMPDH2

7.91e-06357236629054
Pubmed

Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles.

MYH11 TEK

7.91e-06357218612081
Pubmed

Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients.

IMPDH1 IMPDH2

7.91e-06357220061166
Pubmed

T cell activation triggers reversible inosine-5'-monophosphate dehydrogenase assembly.

IMPDH1 IMPDH2

7.91e-06357230154209
Pubmed

A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system.

PRKAR1A PRKAR1B

7.91e-06357212634056
Pubmed

DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.

ABCA1 TOP2A

7.91e-06357223466610
Pubmed

Recently reported familial hypercholesterolemia-related mutations from cases in the Middle East and North Africa region.

ABCA1 APOB

7.91e-06357230694837
Pubmed

Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration.

HTRA1 ERCC6

7.91e-06357231583032
Pubmed

Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis.

PRKAR1A PRKAR1B

7.91e-0635723479018
Pubmed

Alpha/beta-tubulin are A kinase anchor proteins for type I PKA in neurons.

PRKAR1A PRKAR1B

1.58e-05457219056362
Pubmed

A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression.

ABCA1 APOB

1.58e-05457221779326
Pubmed

Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

PRKAR1A PRKAR1B

1.58e-05457224605759
Pubmed

Localization and quaternary structure of the PKA RIβ holoenzyme.

PRKAR1A PRKAR1B

1.58e-05457222797896
Pubmed

ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion.

OSBPL9 APOB

1.58e-05457222906437
Pubmed

The impact of APOA5, APOB, APOC3 and ABCA1 gene polymorphisms on ischemic stroke: Evidence from a meta-analysis.

ABCA1 APOB

1.58e-05457228865324
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

STK10 ABR AGPAT5 GTF3C1 PRKAR1A PRKAR1B POF1B SNTB1 ITPR2

1.61e-0591057936736316
Pubmed

Glucagon and regulation of glucose metabolism.

PRKAR1A PRKAR1B ADCY7

1.82e-053157312626323
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

STK10 ATP6V1A ABR DEPTOR KCNQ5 GTF3C1 VPS45 OSBPL9 PRKAR1B FNIP1 BRWD3

2.56e-051489571128611215
Pubmed

Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes.

PRKAR1A PRKAR1B

2.63e-05557210228048
Pubmed

Immunohistochemical demonstration of Angiopoietin-2 in lymphatic vascular development.

TEK PROX1

2.63e-05557218836739
Pubmed

Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.

DEPTOR SNTB1

2.63e-05557211285235
Pubmed

Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals.

IMPDH1 IMPDH2

2.63e-05557220045992
Pubmed

Patterns of cyclic AMP-dependent protein kinase gene expression during ontogeny of the murine palate.

PRKAR1A PRKAR1B

2.63e-0555727775586
Pubmed

ANKRD9 is associated with tumor suppression as a substrate receptor subunit of ubiquitin ligase.

IMPDH1 IMPDH2

3.94e-05657230293565
Pubmed

Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma.

TEK PROX1

3.94e-05657228920924
Pubmed

Subcellular dynamics of type II PKA in neurons.

PRKAR1A PRKAR1B

3.94e-05657219447092
Pubmed

A lymphatic defect causes ocular hypertension and glaucoma in mice.

TEK PROX1

3.94e-05657225202984
Pubmed

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

NLRP7 NLRP4

3.94e-05657212387869
Pubmed

The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA.

PRKAR1A PRKAR1B

3.94e-05657221812984
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

DHX15 ATP6V1A IMPDH2 GTF3C1 PRKAR1A SCIN SF1 TOP2A ITPR2

4.06e-05102457924711643
Pubmed

Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain.

PRKAR1A PRKAR1B

5.51e-0575722619996
Pubmed

Genome-wide scan of copy number variation in late-onset Alzheimer's disease.

SASH1 TTLL7

5.51e-05757220061627
Pubmed

Dynamic binding of PKA regulatory subunit RI alpha.

PRKAR1A PRKAR1B

5.51e-05757216407073
Pubmed

Phosphorylation of HIV Nef by cAMP-dependent protein kinase.

PRKAR1A PRKAR1B

5.51e-05757215629779
Pubmed

Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes.

ABCA1 APOB

5.51e-05757216204232
Pubmed

Genetic variants influencing circulating lipid levels and risk of coronary artery disease.

ABCA1 GMPR APOB

7.29e-054957320864672
Pubmed

HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism.

PRKAR1A PRKAR1B

7.34e-0585721978848
Pubmed

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.

NLRP7 NLRP4

7.34e-05857212019269
Pubmed

Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemia.

ABCA1 APOB

7.34e-05857215135251
Pubmed

Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha.

PRKAR1A PRKAR1B

7.34e-0585728794865
Pubmed

The identification of different endothelial cell populations within the mouse proepicardium.

MYH11 PROX1

7.34e-05857221932312
Pubmed

HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro.

PRKAR1A PRKAR1B

7.34e-0585727946090
Pubmed

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.

TEK PROX1

7.34e-05857229358379
Pubmed

Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema.

TEK PROX1

7.34e-05857232673288
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

DHX15 GTF3C1 PRKAR1A POF1B SF1

8.47e-0527257531010829
Pubmed

Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.

ABCA1 SNTB1

9.43e-05957216192269
Pubmed

Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.

PRKAR1A PRKAR1B

9.43e-0595727688126
Pubmed

Polymorphisms associated with cholesterol and risk of cardiovascular events.

ABCA1 APOB

9.43e-05957218354102
Pubmed

Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.

ARHGAP5 PRKAR1B

9.43e-05957216777052
Pubmed

A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women.

ABCA1 APOB

9.43e-05957219773416
Pubmed

Genetic dissection of tie pathway in mouse lymphatic maturation and valve development.

TEK PROX1

9.43e-05957224764452
Pubmed

CTPS and IMPDH form cytoophidia in developmental thymocytes.

IMPDH1 IMPDH2

1.18e-041057234022203
Pubmed

Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice.

TEK PROX1

1.18e-041057235021856
Pubmed

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.

ABCA1 ELMO1

1.18e-041057226075824
Pubmed

Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.

PRKAR1A PRKAR1B

1.44e-041157210521398
Pubmed

De novo purine nucleotide biosynthesis.

IMPDH1 IMPDH2

1.44e-04115721574589
Pubmed

Cardiac mouse lymphatics: developmental and anatomical update.

TEK PROX1

1.72e-041257224700724
Pubmed

Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.

PRKAR1A ADCY7

1.72e-04125729611134
Pubmed

Isoform-specific targeting of PKA to multivesicular bodies.

PRKAR1A PRKAR1B

1.72e-041257221502359
Pubmed

A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.

PTGES2 IMPDH1 IMPDH2 VPS45 PRKAR1A ITPR2

1.73e-0450357636217030
Pubmed

Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif.

PRKAR1A PRKAR1B

2.03e-041357218836454
Pubmed

Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children.

PRKAR1A PRKAR1B

2.03e-041357219895210
Pubmed

Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2.

TEK PROX1

2.03e-041357237317851
Pubmed

The HIV-1 matrix protein p17 activates the transcription factors c-Myc and CREB in human B cells.

PRKAR1A PRKAR1B

2.03e-041357220402410
Pubmed

Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection.

PRKAR1A PRKAR1B

2.03e-041357220392842
Pubmed

Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature.

TEK PROX1

2.03e-041357220584329
Pubmed

Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.

PTGES2 DEPTOR AGPAT5 PRKAR1A C3orf20 ELMO1

2.13e-0452357611256614
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

DHX15 ATP6V1A IMPDH2 GTF3C1 BRD3 METTL16 SF1 TOP2A

2.37e-04101457832416067
Pubmed

The genetics of NOD-like receptors in Crohn's disease.

NLRP7 NLRP4

2.37e-041457220403135
Pubmed

NALPs: a novel protein family involved in inflammation.

NLRP7 NLRP4

2.37e-041457212563287
Pubmed

Tie1 is required for lymphatic valve and collecting vessel development.

TEK PROX1

2.37e-041457225576926
Pubmed

Angiopoietin-1 is required for Schlemm's canal development in mice and humans.

TEK PROX1

2.37e-041457229106382
Pubmed

Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis.

DHX15 ARHGAP5 IMPDH2 PRKAR1A

2.41e-0418457423402259
Pubmed

Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.

ABCA1 APOB

2.73e-041557220160193
Pubmed

Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

ABCA1 HTRA1

2.73e-041557220385826
Pubmed

Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery.

ABCA1 APOB

3.12e-041657217855807
Pubmed

Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.

ABCA1 APOB

3.12e-041657220691829
Pubmed

Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

TEK PROX1

3.12e-041657228179430
Pubmed

Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.

MYH11 PROX1

3.12e-041657226542011
Pubmed

Analysis of Placental Arteriovenous Formation Reveals New Insights Into Embryos With Congenital Heart Defects.

MYH11 PROX1

3.53e-041757235126469
Pubmed

Lp(a) and risk of recurrent cardiac events in obese postinfarction patients.

ABCA1 APOB

3.53e-041757218927546
InteractionKCNQ2 interactions

KCNQ5 VPS45 OTUD7A PRKAR1A PRKAR1B

3.94e-0684575int:KCNQ2
InteractionIMPDH1 interactions

DHX15 HTRA1 AGPAT5 IMPDH1 IMPDH2 PRKAR1B

7.83e-06168576int:IMPDH1
InteractionCSNK2A2 interactions

BHLHE41 ABCA1 ERCC6 ABR GTF3C1 BRD3 SF1 TOP2A BRWD3 TTLL7

2.94e-057185710int:CSNK2A2
InteractionLLGL2 interactions

BHLHE41 IMPDH2 PRKAR1A SF1 BRWD3

3.69e-05133575int:LLGL2
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP7 NLRP4

1.32e-0325392994
GeneFamilyNLR family

NLRP7 NLRP4

1.32e-0325392666
GeneFamilyPDZ domain containing

HTRA1 DEPTOR SNTB1

4.27e-031523931220
CoexpressionGRYDER_PAX3FOXO1_TOP_ENHANCERS

AGPAT5 SASH1 VASH2 GMPR SNTB1 TOP2A ELMO1 PROX1

4.84e-06441578M172
CoexpressionGRYDER_PAX3FOXO1_ENHANCERS_IN_TADS

AGPAT5 SASH1 VASH2 PRKAR1A GMPR CNTLN SNTB1 TOP2A ELMO1 TTLL7 PROX1

9.47e-0610095711M157
CoexpressionYAGI_AML_WITH_T_8_21_TRANSLOCATION

STK10 ABR APOB BRINP1 TEK ADCY7 ELMO1

1.57e-05372577M19261
CoexpressionROSS_ACUTE_MYELOID_LEUKEMIA_CBF

MYH11 ABR DEPTOR ADCY7

3.10e-0582574M7804
CoexpressionZHENG_CORD_BLOOD_C4_PUTATIVE_EARLY_ERYTHROID_COMMITMENT

ABCA1 DEPTOR CPA3 ELMO1

5.99e-0597574M39213
CoexpressionGSE15767_MED_VS_SCS_MAC_LN_UP

ABCA1 SASH1 PRKAR1B FNIP1 CPA3

7.46e-05200575M3584
CoexpressionYAGI_AML_WITH_11Q23_REARRANGED

ABR SASH1 GMPR SF1 ADCY7 ITPR2

1.04e-04346576M17123
CoexpressionGOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION

ABCA1 BRWD3 ELMO1

1.13e-0443573MM926
CoexpressionGOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION

ABCA1 BRWD3 ELMO1

1.13e-0443573M2370
CoexpressionSCHMIDT_POR_TARGETS_IN_LIMB_BUD_DN

ABCA1 CPA3

1.29e-048572MM933
CoexpressionSCHMIDT_POR_TARGETS_IN_LIMB_BUD_DN

ABCA1 CPA3

1.29e-048572M2384
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYH11 KCNQ5 OTUD7A ANO3 TTLL7

1.50e-06152575bd1f36b436d8ab7dd8420f595b97d851eab31a38
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYH11 KCNQ5 OTUD7A ANO3 TTLL7

1.50e-06152575ee329249a034a969a16b26a224aa04249d67382d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1 ITPR2

1.93e-06160575174a4ab27114efcc63be36929b80680be3c35c9b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1 ITPR2

2.52e-061695754b3a7b4a497178799b6b2f0b744f5fb752cee31a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1 ITPR2

2.91e-061745755f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1 ITPR2

2.99e-0617557577c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1 ITPR2

3.34e-06179575e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 KCNQ5 VASH2 PRKAR1B TTLL7

3.34e-06179575bfc226bcf0b93525992344f968268a261d86fcbf
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH11 KCNQ5 VASH2 PRKAR1B TTLL7

3.34e-0617957536ad18f52e175ab636ceaa3be81212fa362c96c1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1 ITPR2

3.52e-0618157530729f0364f719c044712a51453e22dc2c1a232b
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP|bone_marrow / Manually curated celltypes from each tissue

DEPTOR IMPDH2 GMPR CPA3 TEK

3.82e-06184575b81a2a95944cee8fec13d63dc0d95496e67aa937
ToppCellnormal_Lung-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

ARHGAP5 MYH11 KCNQ5 OSBPL9 BRWD3

4.13e-06187575a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP5 APOB POF1B BRWD3 ITPR2

4.58e-0619157560c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP5 APOB POF1B BRWD3 ITPR2

4.58e-06191575973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1 ITPR2

5.07e-06195575f7d9adadd37209ce1a38e5d621607b9c9270fed8
ToppCell(2)_Fibroblasts-(23)_Fibro-4|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

HTRA1 KCNQ5 OSBPL9 CCDC25 SCIN

5.46e-06198575e0ef49ec0f87cc87b45efa297b9ff6c35b7a2ba9
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

BHLHE41 HTRA1 ABR ELMO1 ITPR2

5.73e-06200575a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

BHLHE41 HTRA1 ABR ELMO1 ITPR2

5.73e-06200575dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

BHLHE41 HTRA1 ABR ELMO1 ITPR2

5.73e-062005753bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

BHLHE41 HTRA1 ABR ELMO1 ITPR2

5.73e-0620057521bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

BHLHE41 HTRA1 ABR ELMO1 ITPR2

5.73e-06200575a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

BHLHE41 HTRA1 ABR ELMO1 ITPR2

5.73e-0620057533036d21c1c82109284473a515c4f890b33fdd5c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

4.09e-0515057487968ce885a4959616f0321f58517fe8029ba1b1
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYH11 KCNQ5 OSBPL9 ANO3

4.41e-051535741524557514668f515ac1bbe847611f564b265b42
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK10 ABR ITGAD ADCY7

4.88e-05157574ec433d2fe827abdb647be4176c231b7052482b6f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast-Mast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DEPTOR GMPR CPA3 BRINP1

5.51e-0516257430508c4007faa38b76246e3c6d7b3fde4492cc85
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DEPTOR GMPR CPA3 BRINP1

5.51e-0516257433b73c6727b5c5ada2dddf304f56d84397725ca8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast-Mast-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DEPTOR GMPR CPA3 BRINP1

5.51e-0516257444ef0932ee38964ff11edc2aa14698d9db3b2b6b
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK10 ABR ITGAD ADCY7

5.65e-051635748dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK10 ABR ITGAD ADCY7

5.65e-05163574fd243ca223079033be480a24817a399f281fa4d4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

5.78e-05164574d847d509bb1791638032ade6755d8164586b5bd5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

5.92e-051655749bd332e5ede759a00a47728ea5558c215efdd77a
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

5.92e-05165574a6c6de17fec678ad0cac3138dde3a14cc39ffd26
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

6.06e-051665746fe8db8d45177a78605681f22e04fa8d0594f2df
ToppCell(3)_DC_plasmacytoid|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

DHX15 AGPAT5 NLRP7 VASH2

6.35e-051685748a913db9b2a1a4ff96fb139734a3834e6aa263f1
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A SCIN SNTB1 ITPR2

6.50e-051695742a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A SCIN SNTB1 ITPR2

6.50e-05169574a4fd646b9bf87225131fca530bd6b52df9eaf489
ToppCell3'_v3-blood-Mast|blood / Manually curated celltypes from each tissue

GMPR CPA3 SCIN TTLL7

6.96e-05172574e7a46bbeff749ca59b9f1357409ce1ad59dd22dd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A SCIN SNTB1 ITPR2

7.11e-051735740bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCellBAL-Control-Myeloid-pDC-pDC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NLRP7 VASH2 NLRP4 REEP2

7.27e-05174574ab654e87c7eab7f33adc61be7a86da5c4d88008d
ToppCellBAL-Control-Myeloid-pDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

NLRP7 VASH2 NLRP4 REEP2

7.27e-05174574d9bccff5258c4277bdd1edbd87e17c327ec125e8
ToppCellBAL-Control-Myeloid-pDC-pDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

NLRP7 VASH2 NLRP4 REEP2

7.27e-051745742453419842fd22d066631615403393bfe4449bb8
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

BHLHE41 NLRP7 TOP2A TTLL7

7.44e-0517557489bf89466191da14896ed8928027f5b911436c22
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GMPR SCIN SNTB1 ITPR2

7.44e-051755741d8da48236549c01381f777ce5b2937f9f86acc2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

7.44e-0517557498947a226b5a2ac7091ff9d34243ea7736add973
ToppCellBAL-Control-Myeloid-pDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NLRP7 VASH2 NLRP4 REEP2

7.44e-051755746d5bdfbe53608e01c3845ecd908ca6d0fecc58f8
ToppCellBAL-Control-Myeloid-pDC-pDC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NLRP7 VASH2 NLRP4 REEP2

7.44e-051755746839ee3bb4457d13cb08ca8eb79ae33ddd256783
ToppCellBAL-Control-Myeloid-pDC-pDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NLRP7 VASH2 NLRP4 REEP2

7.44e-051755749d6135e183179968555670abec39dff9da2c3219
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

7.60e-0517657425ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

7.60e-05176574cb21342dd135cc80a50aafe7bf8bf31265db68dd
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Endothelial-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GMPR TEK C3orf20 BRWD3

7.60e-05176574a3f27b5d7edf2d396c085efbe35305cfa0afa565
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SNTB1 ITPR2

7.60e-05176574c2c4306476989bc2fb30dab00250ef7915842f13
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STK10 KCNQ5 CPA3 TOP2A

7.60e-051765741f8d5a48fedbb4c86272c9b5a0f1ef573350357b
ToppCell3'_v3-blood-Mast-Mast_cell_granulo-myelo|blood / Manually curated celltypes from each tissue

GMPR CPA3 SCIN TTLL7

7.60e-05176574d421b6b8e13894dbcf29548c0a6516c3dee8f9b1
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V1A SCIN PROX1 ITPR2

7.77e-051775746d89042bda8e244babb68929e84b25edcb545a77
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V1A SCIN PROX1 ITPR2

7.77e-05177574daaccf1249dcf816df4caca695a944f53078291a
ToppCellControl-Myeloid-MoAM2,_CCL18|Myeloid / Condition, Lineage and Cell class

ABCA1 DEPTOR ITGAD TOP2A

7.77e-05177574470f54fe2b21c7350ea471e02039461a3808f700
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYH11 KCNQ5 OSBPL9 ANO3

7.77e-05177574b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

7.77e-051775748e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V1A SCIN PROX1 ITPR2

7.77e-05177574338bdda26796bf4e16072878c070212d1006cf57
ToppCellNS-moderate-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ATP6V1A SCIN PROX1 ITPR2

7.77e-0517757499500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V1A SCIN PROX1 ITPR2

7.77e-05177574c5a16f984c836dbf7d0faf061677844167ab612a
ToppCell10x5'-GI_large-bowel-Mast|GI_large-bowel / Manually curated celltypes from each tissue

ABCA1 GMPR CPA3 SCIN

7.94e-05178574d10ed2543c96e1a2373f847e0b82144771e26d07
ToppCell10x5'-GI_large-bowel-Mast-Mast_cells|GI_large-bowel / Manually curated celltypes from each tissue

ABCA1 GMPR CPA3 SCIN

7.94e-051785748fc5f735afa25ae43c2acb1c710ade6e9e093e3c
ToppCell3'_v3-bone_marrow-Myeloid_Mac-Macrophage|bone_marrow / Manually curated celltypes from each tissue

BHLHE41 ABCA1 HTRA1 SASH1

7.94e-0517857411a338032b59b936c5e65517c4160f7dd47a2cda
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SASH1 TEK SCIN ELMO1

8.12e-051795741ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

ABCA1 SASH1 CNTLN TEK

8.29e-051805747be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell368C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MYH11 ABR TIGD1 SNTB1

8.29e-05180574eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell368C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MYH11 ABR TIGD1 SNTB1

8.29e-05180574ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BHLHE41 HTRA1 TEK TTLL7

8.29e-05180574dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BHLHE41 HTRA1 TEK TTLL7

8.29e-05180574423454e3390080ae03bb3cbb267255ebfe4df080
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DEPTOR SASH1 BRINP1 SNTB1

8.47e-051815749d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellcritical-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DEPTOR GMPR CPA3 TTLL7

8.47e-05181574f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCell3'_v3-bone_marrow-Myeloid_Mac|bone_marrow / Manually curated celltypes from each tissue

BHLHE41 ABCA1 HTRA1 SASH1

8.66e-05182574e1d6b5de5bd1d11e968da3a55e5326ef252f55ba
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ATP6V1A SCIN PROX1 ITPR2

8.66e-051825746e7dac78dc030f74e546b9f6db07556e9bb13ac2
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DEPTOR SASH1 BRINP1 SNTB1

8.66e-05182574eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ATP6V1A SCIN PROX1 ITPR2

8.66e-05182574cd972d30519db706477c6b0c901165b81b74abed
ToppCellCOVID-19-kidney-CD-IC-A|kidney / Disease (COVID-19 only), tissue and cell type

GMPR SCIN SNTB1 ITPR2

8.84e-051835745c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V1A SCIN PROX1 ITPR2

9.03e-05184574a60802e11dcc5f932811260b08a95a32f60f6b19
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V1A SCIN PROX1 ITPR2

9.03e-0518457439c230d32e4259bc784e0edfd9e2884c96898564
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V1A SCIN PROX1 ITPR2

9.03e-051845742a2fb691cc9414ef5b06c26239d2da03d6d7e5c2
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

ABCA1 SASH1 TEK ITPR2

9.03e-0518457467164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PRKAR1B TEK POF1B PROX1

9.22e-05185574f9f48251bc33eb6bf2cff580d1a3207d21450aa0
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ABCA1 SNTB1 ELMO1 ITPR2

9.22e-051855741d874608aa2062024323512f68889219471b2f00
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

9.22e-051855749438097e94219c1db922b8507e3a29106d32a923
ToppCellwk_20-22-Hematologic-Myeloid-MEP|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DEPTOR IMPDH2 CPA3 TOP2A

9.41e-05186574e6e9135a65da568b3a7d0e378f8ce9ae34483968
ToppCellLV-10._Endothelium_II|World / Chamber and Cluster_Paper

SASH1 TRIML2 TEK ELMO1

9.61e-051875747876dcb4800c2e54874df3d933efb79307a64a97
ToppCell10x5'-Lung-Mast|Lung / Manually curated celltypes from each tissue

GMPR CPA3 SCIN TTLL7

9.61e-05187574f8ac5ca5cbe9c6f3d8c0fffc20fe08ca1aea43c0
ToppCell10x5'-Lung-Mast-Mast_cells|Lung / Manually curated celltypes from each tissue

GMPR CPA3 SCIN TTLL7

9.61e-05187574da275d2c774b3e6a8ed77f777dd0676ecf2ddd2c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

9.61e-051875747b0168bdaa7c6c6b39878aff6a17f0943189a380
ToppCellnormal_Lung-Myeloid_cells-pDCs|normal_Lung / Location, Cell class and cell subclass

ARHGAP5 KCNQ5 OSBPL9 BRWD3

9.61e-05187574d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GMPR SCIN SNTB1 ITPR2

9.81e-05188574e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

TEK POF1B ELMO1 ITPR2

1.00e-041895747346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

AGPAT5 IMPDH2 GMPR CPA3

1.00e-0418957456156325cc36b1329bf483f81bb74f371ef15e20
ToppCellRA-10._Endothelium_II|World / Chamber and Cluster_Paper

SASH1 TEK ELMO1 ITPR2

1.00e-0418957475c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

SASH1 TEK ELMO1 ITPR2

1.00e-04189574c81787a8c662db5d7814c583dd64562857629e81
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYH11 KCNQ5 ANO3 TTLL7

1.02e-041905742e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1A GMPR SCIN SNTB1

1.02e-04190574bb3b396d78887d5d6f93a05c8ed4d703591bf33f
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABCA1 DEPTOR ELMO1 ITPR2

1.02e-04190574f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STK10 KCNQ5 ADCY7 ELMO1

1.02e-04190574ba61f04fd38efae01f721ba616252d1372ff1002
Drugallopurinol riboside

IMPDH1 IMPDH2 GMPR

1.24e-069573CID000085337
Drug3-deazaguanosine

IMPDH1 IMPDH2 GMPR

3.22e-0612573CID000124316
DrugBrd-MP

IMPDH1 IMPDH2 GMPR

5.31e-0614573CID000124908
Drug6-thioguanine nucleotide

ABCA1 IMPDH1 IMPDH2

5.31e-0614573CID003034646
Drugthiopurinol

IMPDH1 IMPDH2 GMPR

5.31e-0614573CID000667510
Drughydroxymethylphosphonate

IMPDH1 IMPDH2

6.16e-062572CID000075795
Drug6-Chloropurine Riboside, 5'-Monophosphate

IMPDH1 IMPDH2

6.16e-062572DB03948
Drugpurinogen

IMPDH1 IMPDH2

6.16e-062572CID003081226
DrugAC1L9X6T

IMPDH1 IMPDH2

6.16e-062572CID000477594
DrugMycophenolic acid

IMPDH1 IMPDH2

6.16e-062572DB01024
DrugMycophenolate mofetil

IMPDH1 IMPDH2

6.16e-062572DB00688
DrugAir Pollutants

ABCA1 DEPTOR SASH1 TRIML2 OSBPL9 FNIP1 HNF4G POF1B ELMO1 CCDC144A ITPR2

1.44e-059175711ctd:D000393
DrugAC1L59F0

IMPDH1 IMPDH2

1.84e-053572CID000220847
DrugAC1L9X6Q

IMPDH1 IMPDH2

1.84e-053572CID000477593
Drugoxanosine-5'-monophosphate

IMPDH1 IMPDH2

1.84e-053572CID000477551
Drugallopurinol

IMPDH1 IMPDH2 GMPR

1.92e-0521573CID000002094
DrugAC1L1KXQ

IMPDH1 IMPDH2 GMPR

1.92e-0521573CID000005698
Drugthiazole-4-carboxamide adenine dinucleotide

IMPDH1 IMPDH2 GMPR

3.29e-0525573CID000073680
DrugSJ-3366

IMPDH1 IMPDH2

3.68e-054572CID000474597
DrugAC1O57LV

IMPDH1 IMPDH2

3.68e-054572CID006479288
Drug6'-C-methylneplanocin A

IMPDH1 IMPDH2

3.68e-054572CID000073215
DrugAC1L8X8C

IMPDH1 IMPDH2

3.68e-054572CID000409590
DrugSl-1250

IMPDH1 IMPDH2

3.68e-054572CID000125244
DrugAC1MQVYC

IMPDH1 IMPDH2

3.68e-054572CID003483303
DrugNSC 125640

IMPDH1 IMPDH2

3.68e-054572CID000097467
Drug7B-forskolin

PTGES2 PRKAR1A ADCY7

3.71e-0526573CID000130638
Drugparacrystals

STK10 ABR IMPDH2 METTL16 ADCY7

5.17e-05161575CID000004685
Drug2',3'-dideoxyadenosine

IMPDH1 IMPDH2 PRKAR1A ADCY7

5.34e-0582574CID000020039
Drugdiphenimide

IMPDH1 IMPDH2

6.13e-055572CID000286514
DrugAC1L8NVV

IMPDH1 IMPDH2

6.13e-055572CID000429656
DrugSM-108

IMPDH1 IMPDH2

6.13e-055572CID000124343
Druggenkwadaphnin

IMPDH1 IMPDH2

6.13e-055572CID000124210
Drug2'-dC

IMPDH1 IMPDH2 GMPR APOB NLRP4

6.88e-05171575CID000000637
Drugxanthosine 5'-phosphate

IMPDH1 IMPDH2 GMPR

7.01e-0532573CID000001190
DrugAC1Q6RZK

IMPDH1 IMPDH2 GMPR

7.01e-0532573CID000000153
DrugAC1LCV0V

IMPDH1 IMPDH2 GMPR

7.01e-0532573CID000656468
Drug2-deoxyguanosine

IMPDH1 IMPDH2 GMPR APOB ANO3

8.32e-05178575CID000000638
Druggeldanamycin; Up 200; 1uM; PC3; HT_HG-U133A

ABCA1 REEP2 SF1 ADCY7 TTLL7

8.54e-051795754452_UP
Drug2,3-dihydrohelenalin

IMPDH1 IMPDH2

9.18e-056572CID000037128
Drugmicrolenin

IMPDH1 IMPDH2

9.18e-056572CID000442281
DrugVP32947

IMPDH1 IMPDH2

9.18e-056572CID005482375
DrugVF 122

IMPDH1 IMPDH2

9.18e-056572CID000100590
DrugAC1NV8XC

IMPDH1 IMPDH2

9.18e-056572CID005473891
Drug6-thioguanosine

ABCA1 IMPDH1 IMPDH2

1.00e-0436573CID002724387
DrugZardaverine [101975-10-4]; Down 200; 15uM; HL60; HT_HG-U133A

PTGES2 DEPTOR IMPDH1 METTL16 SNTB1

1.02e-041865752926_DN
Drug17-AAG; Up 200; 1uM; PC3; HT_HG-U133A

ABCA1 PRKAR1B GMPR METTL16 ADCY7

1.10e-041895754430_UP
DrugIsoetharine mesylate salt [7279-75-6]; Down 200; 12uM; HL60; HT_HG-U133A

IMPDH1 EIF2B3 VASH2 METTL16 ITPR2

1.25e-041945752711_DN
DrugBeclomethasone dipropionate [5534-09-8]; Down 200; 7.6uM; HL60; HT_HG-U133A

ABCA1 PRKAR1A BRINP1 METTL16 SNTB1

1.28e-041955753001_DN
Drugfavipiravir

IMPDH1 IMPDH2

1.28e-047572CID000492405
Drug3'-fluoro-3'-deoxyadenosine

IMPDH1 IMPDH2

1.28e-047572CID000122619
Drug0317956-0000 [391210-11-0]; Up 200; 10uM; PC3; HT_HG-U133A

GMPR BRINP1 SF1 PROX1 ITPR2

1.31e-041965754331_UP
DrugColistin sulfate [1264-72-8]; Down 200; 3uM; MCF7; HT_HG-U133A

STK10 ERCC6 VASH2 METTL16 ITPR2

1.31e-041965752851_DN
DrugScopolamine hydrochloride [55-16-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

ATP6V1A DEPTOR SASH1 PRKAR1B ITPR2

1.40e-041995753357_DN
Drug4-methylpiperidine

IMPDH1 IMPDH2

1.71e-048572CID000069381
Drugtrimethylamine-cyanoborane

IMPDH1 IMPDH2

1.71e-048572CID006328234
Drug1,4-Aptd

IMPDH1 IMPDH2

1.71e-048572CID000152126
DrugB Hm

IMPDH1 IMPDH2

1.71e-048572CID000100038
DrugMIV-210

IMPDH1 IMPDH2

1.71e-048572CID000072183
Drug27764P

IMPDH1 IMPDH2

1.71e-048572CID005357051
Drug2'-deoxy-2'-fluoroadenosine

IMPDH1 IMPDH2

1.71e-048572CID000100253
DrugCosopt

MYH11 ABR IMPDH1 IMPDH2 TEK SF1

2.06e-04341576CID000003154
Drugtemacrazine

IMPDH1 IMPDH2

2.19e-049572CID000472178
Drug6-ethylmercaptopurine

IMPDH1 IMPDH2

2.19e-049572CID000094971
DrugTCN-P

IMPDH1 IMPDH2

2.19e-049572CID000043860
Drug2,3,2-tet

APOB HNF4G

2.19e-049572CID000078479
DrugAC1Q6O14

IMPDH1 IMPDH2

2.19e-049572CID000073319
Drugxanthine

IMPDH1 IMPDH2 GMPR ADCY7

2.26e-04119574CID000001188
DrugNSC289637

IMPDH1 IMPDH2 GMPR

2.38e-0448573CID000004213
Drug1 mN-9

IMPDH1 IMPDH2

2.74e-0410572CID000122108
Drugphthaloylhydrazine

IMPDH1 IMPDH2

2.74e-0410572CID000219401
DrugPGE1 alcohol

PTGES2 ABCA1

2.74e-0410572CID005283054
DrugAC1O592B

IMPDH1 IMPDH2

2.74e-0410572CID006480203
DrugDPC 083

IMPDH1 IMPDH2

2.74e-0410572CID005327770
Drug2,4-hexanedione

IMPDH1 IMPDH2

2.74e-0410572CID000076355
Drug5'-noraristeromycin

IMPDH1 IMPDH2

2.74e-0410572CID000126704
DrugN-ethylmaleimide

ATP6V1A MYH11 KCNQ5 GTF3C1 VPS45 CPA3 ADCY7

2.76e-04511577CID000004362
DrugFPMPA

IMPDH1 IMPDH2

3.34e-0411572CID000122652
Druggermacranolide

IMPDH1 IMPDH2

3.34e-0411572CID000299917
Drug2-deoxyadenosine

IMPDH1 IMPDH2 NLRP4 ADCY7

3.46e-04133574CID000000636
DrugAcetazolamide

ABCA1 HTRA1 ITPR2

3.56e-0455573ctd:D000086
Drug6-thioxanthine

IMPDH1 IMPDH2

4.00e-0412572CID001268107
Drug5-Erfic

IMPDH1 IMPDH2

4.00e-0412572CID000122653
Drugthiazole-4-carboxamide

IMPDH1 IMPDH2

4.00e-0412572CID000445276
DrugF-ddA

IMPDH1 IMPDH2

4.00e-0412572CID000072180
Diseasefree cholesterol to total lipids in small HDL percentage

RNF214 ABCA1 PRKAR1A APOB

2.72e-0651564EFO_0022285
Diseasetotal lipids in very large HDL measurement

ABCA1 PRKAR1A APOB

2.72e-0466563EFO_0022312
DiseaseHyperlipoproteinemia Type IIb

ABCA1 APOB

2.72e-0413562C1704417
Diseasecholesterol in very large HDL measurement

ABCA1 PRKAR1A APOB

3.10e-0469563EFO_0022229
Diseasepimelic acid measurement, 3-methyladipic acid measurement

ABCA1 SNTB1

3.17e-0414562EFO_0010449, EFO_0010524
DiseaseOpioid use measurement

NLRP7 SNTB1

3.66e-0415562EFO_0009937
DiseaseHyperlipoproteinemia Type IIa

ABCA1 APOB

4.17e-0416562C0745103
DiseaseAge-related macular degeneration

HTRA1 ERCC6

5.31e-0418562cv:C0242383
DiseaseHypercholesterolemia, Familial

ABCA1 APOB

5.31e-0418562C0020445
DiseaseAlopecia

HTRA1 PRKAR1A

5.93e-0419562C0002170
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

ABCA1 AGPAT5 APOB

8.93e-0499563EFO_0004611, EFO_0007878
Diseaselow density lipoprotein cholesterol measurement, alcohol drinking

ABCA1 AGPAT5 APOB

9.73e-04102563EFO_0004329, EFO_0004611
DiseaseAlzheimer disease, high density lipoprotein cholesterol measurement

ABCA1 APOB

1.12e-0326562EFO_0004612, MONDO_0004975
Diseasepathological myopia

DHX15 ABCA1 SNTB1

1.24e-03111563EFO_0004207
DiseaseAge related macular degeneration

HTRA1 ERCC6

1.49e-0330562C0242383
Diseasecholesteryl esters to total lipids in large LDL percentage

ABCA1 APOB

1.59e-0331562EFO_0022249
DiseaseAcute Myeloid Leukemia, M1

DHX15 MYH11 ADCY7

1.75e-03125563C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

DHX15 MYH11 ADCY7

1.75e-03125563C1879321
Diseaseangina pectoris

APOB BRINP1 BRWD3

1.75e-03125563EFO_0003913
Diseaseautoimmune thyroid disease

SASH1 ADCY7 ELMO1

1.79e-03126563EFO_0006812
Diseasefatty liver disease (biomarker_via_orthology)

ABCA1 APOB

1.80e-0333562DOID:9452 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
EFSMKFTSRDMSLKR

ABR

621

Q12979
MDLSTVKRKMDGREY

BRD3

356

Q15059
SSGSMEKRKSMYTRD

ELMO1

341

Q92556
KSEMATMKVRSGRYD

CNTLN

806

Q9NXG0
LTMYMDKSRLDRKSG

BRINP1

141

O60477
SLYMCKPKRSMKRDD

BHLHE41

26

Q9C0J9
RLLLYSQKDTSMKDM

ABCA1

111

O95477
SNKKSRIYSMMLRLS

BRWD3

1406

Q6RI45
LKMRASVRMTRYLES

ADCY7

476

P51828
TILKYMTDGMLLREA

DHX15

231

O43143
YLLRRMKSDVKMSLS

ERCC6

741

Q03468
SKSMGRMQTYFRRIK

ANO3

241

Q9BYT9
DSSRNDMKRKFALTM

ITPR2

821

Q14571
YTSKDKMMRGSRRGC

OSBPL9

36

Q96SU4
SKRYLSDLARDMLMQ

LEXM

381

Q3ZCV2
IRLKKYRGMGSLDAM

IMPDH2

406

P12268
AMMYSGELKFEKRTS

IMPDH2

481

P12268
SLKAEYKMGRMRSHG

KIAA1109

2996

Q2LD37
SNLTKDRSMRKSFDM

KCNQ5

796

Q9NR82
MALSKSMHARNRYKD

METTL16

1

Q86W50
RKDLCMKVMRERTGY

NLRP4

81

Q96MN2
DLVLRKALYTMMRTG

OTUD7A

226

Q8TE49
YILQMRGMSDKSLRL

POF1B

316

Q8WVV4
KKREMDELRSYSSLM

CCDC25

176

Q86WR0
LLGATKRSMMYKDIL

HNF4G

181

Q14541
VRLKKYRGMGSLDAM

IMPDH1

406

P20839
VSYKATLGDRMLMRA

ITGAD

881

Q13349
FRAYDASLAMLMRKG

EIF2B3

121

Q9NR50
DKRLAAYLMLMRSPS

APOB

556

P04114
KYIGIRMMSLTSSKA

HTRA1

381

Q92743
TYGRNKIMTKLLDRM

CPA3

196

P15088
FKSKMLSEYLRGQMR

FNIP1

1116

Q8TF40
RISNMDDKVYKMSRA

C3orf20

526

Q8ND61
KAFMRGQRLYEKLMS

DEPTOR

131

Q8TB45
MGSTLRKRKMYEEFL

PRKAR1A

236

P10644
MGSTLRKRKMYEEFL

PRKAR1B

236

P31321
RKLKLFYGMSSDTAM

GMPR

261

P36959
LKSYMERNMLERGKA

CCDC144A

1181

A2RUR9
LKMSSDDGIRMLYLD

SNTB1

486

Q13884
RKMAKLYMVSDASGS

SCIN

246

Q9Y6U3
RKLLKRANSYEDAMM

PROX1

71

Q92786
LLDEGAMLLYKTMTR

NLRP7

801

Q8WX94
MGAAAMYLISKRLKS

PTGES2

281

Q9H7Z7
SAKRKASMGMLRAFL

ARHGAP5

856

Q13017
YMIAGAKEKMRSDLL

MYH11

286

P35749
LDKMMTERTLLKERY

RNF214

226

Q8ND24
FKKMIESEYSMRLRL

TRIML2

101

Q8N7C3
RDKSYETMMRVGKRG

REEP2

111

Q9BRK0
ERKSQLMRKASPMSY

TIGD1

536

Q96MW7
RSEGKTRMAMYKKSL

STK10

811

O94804
MRKRMSKKYSSSVSE

SASH1

461

O94885
REHMGDILYKLSSMK

ATP6V1A

571

P38606
YARDMRMKILKPASA

VASH2

286

Q86V25
LMMDLRNKGVSEKYR

VPS45

406

Q9NRW7
DGLRMDAAIKRMKEY

TEK

846

Q02763
DSLKTLRYGKIMIMT

TOP2A

526

P11388
LTAGMLMTDAGRKLY

AGPAT5

331

Q9NUQ2
RRSKYDILMEKLSVM

GTF3C1

251

Q12789
KARMDKEYLSLMAEL

SF1

306

Q15637
ARNMTKMIKSRPLDY

TTLL7

111

Q6ZT98