Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	ABCA1 NPR3 GPR37 MC1R OR1C1 OR2S2 GRIK2 OR14C36 OR2F1 OR2T11 OR8U9 CHRNE IFNGR2 QRFPR OR4C3 NPY4R2 IGF1R OR13D1 NPY4R PTPRK TLR1 GPR156 ADGRD2 GABBR1 EPHA1	3.84e-07	1353	120	25	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	NPR3 GPR37 MC1R OR1C1 OR2S2 OR14C36 OR2F1 OR2T11 OR8U9 QRFPR OR4C3 NPY4R2 OR13D1 NPY4R GPR156 ADGRD2 GABBR1	2.16e-05	884	120	17	GO:0004930
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	QRFPR NPY4R2 NPY4R	3.37e-05	11	120	3	GO:0004983
GeneOntologyMolecularFunction	G protein-coupled GABA receptor activity	GPR156 GABBR1	1.07e-04	3	120	2	GO:0004965
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NPR3 GPR37 MC1R QRFPR NPY4R2 NPY4R	1.53e-04	133	120	6	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	NPR3 GPR37 MC1R QRFPR NPY4R2 NPY4R	2.02e-04	140	120	6	GO:0001653
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	2.13e-04	4	120	2	GO:0001602
GeneOntologyMolecularFunction	sphingolipid transporter activity	ABCA1 ATP10B ABCG2	2.24e-04	20	120	3	GO:0046624
GeneOntologyMolecularFunction	neuropeptide receptor activity	GPR37 QRFPR NPY4R2 NPY4R	2.89e-04	53	120	4	GO:0008188
GeneOntologyCellularComponent	G protein-coupled receptor heterodimeric complex	GPR156 GABBR1	9.60e-05	3	119	2	GO:0038039
Domain	ARM-type_fold	WAPL MROH5 CUL9 TMCO6 NBEA FOCAD DOCK5 AP4E1 IPO9 PSME4 PIK3C2A TTC12 MMS19	2.32e-07	339	118	13	IPR016024
Domain	ARM-like	MROH5 CUL9 TMCO6 NBEA AP4E1 IPO9 PSME4 TTC12 CEP70 MMS19	8.35e-06	270	118	10	IPR011989
Domain	NPY_rcpt	QRFPR NPY4R2 NPY4R	2.01e-05	9	118	3	IPR000611
Domain	NPY4_rcpt	NPY4R2 NPY4R	3.96e-05	2	118	2	IPR001933
Domain	fn3	NCAM1 IGDCC4 IFNGR2 IGF1R PTPRK ANKFN1 EPHA1	7.64e-05	162	118	7	PF00041
Domain	-	MROH5 CUL9 TMCO6 AP4E1 IPO9 PSME4 TTC12 MMS19	8.38e-05	222	118	8	1.25.10.10
Domain	GPCR3_GABA-B	GPR156 GABBR1	1.18e-04	3	118	2	IPR002455
Domain	FN3	NCAM1 IGDCC4 IFNGR2 IGF1R PTPRK ANKFN1 EPHA1	1.75e-04	185	118	7	SM00060
Domain	Neural_cell_adh	NCAM1 HMCN1	2.36e-04	4	118	2	IPR009138
Domain	FN3	NCAM1 IGDCC4 IFNGR2 IGF1R PTPRK ANKFN1 EPHA1	2.73e-04	199	118	7	PS50853
Domain	GPCR_Rhodpsn_7TM	GPR37 MC1R OR1C1 OR2S2 OR14C36 OR2F1 OR2T11 OR8U9 QRFPR OR4C3 NPY4R2 OR13D1 NPY4R	3.18e-04	670	118	13	IPR017452
Domain	7tm_1	GPR37 MC1R OR1C1 OR2S2 OR14C36 OR2F1 OR2T11 OR8U9 QRFPR OR4C3 NPY4R2 OR13D1 NPY4R	3.51e-04	677	118	13	PF00001
Domain	FN3_dom	NCAM1 IGDCC4 IFNGR2 IGF1R PTPRK ANKFN1 EPHA1	3.67e-04	209	118	7	IPR003961
Domain	G_PROTEIN_RECEP_F1_1	GPR37 MC1R OR1C1 OR2S2 OR14C36 OR2F1 OR2T11 OR8U9 QRFPR OR4C3 NPY4R2 OR13D1 NPY4R	3.92e-04	685	118	13	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR37 MC1R OR1C1 OR2S2 OR14C36 OR2F1 OR2T11 OR8U9 QRFPR OR4C3 NPY4R2 OR13D1 NPY4R	4.26e-04	691	118	13	PS50262
Domain	GPCR_Rhodpsn	GPR37 MC1R OR1C1 OR2S2 OR14C36 OR2F1 OR2T11 OR8U9 QRFPR OR4C3 NPY4R2 OR13D1 NPY4R	4.32e-04	692	118	13	IPR000276
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	WAPL MYO9A AP4E1 CMIP IPO9 PPP3CA PSME4 TLN1 MARF1 MMS19 DDHD2	1.87e-08	322	121	11	26514267
Pubmed	A probabilistic classifier for olfactory receptor pseudogenes.	OR1C1 OR2S2 OR2F1 OR2T11	6.71e-06	35	121	4	16939646
Pubmed	Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein.	ZNF423 ZNF521	1.20e-05	2	121	2	12393497
Pubmed	GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability.	PSAP GPR37	1.20e-05	2	121	2	24371137
Pubmed	Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation.	EXOSC10 MTREX	1.20e-05	2	121	2	32350160
Pubmed	Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes.	AKAP6 PPP3CA	1.20e-05	2	121	2	23261540
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DHX16 EXOSC10 WAPL POLR1A MYO9A KIF4A IPO9 NOP14 PSME4 PIK3C2A TLN1 EIF2B3 PLEKHA5 MMS19 EXOC2 MTREX	1.93e-05	1353	121	16	29467282
Pubmed	Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.	ZNF423 ZNF521 NCAM1	2.23e-05	16	121	3	17521568
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	DENND5B HIVEP1 STXBP5L MSH4 UBR7 AP4E1 PIK3C2A PAK2 ABCG2 DDHD2 ALPK2	2.91e-05	686	121	11	29987050
Pubmed	MAP3K4 promotes fetal and placental growth by controlling the receptor tyrosine kinases IGF1R/IR and Akt signaling pathway.	MAP3K4 IGF1R	3.59e-05	3	121	2	35921893
Pubmed	The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.	PPP3CA CABIN1	3.59e-05	3	121	2	15671033
Pubmed	GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.	PSAP GPR37	3.59e-05	3	121	2	23690594
Pubmed	ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure.	NCAM1 TTC12	3.59e-05	3	121	2	23303482
Pubmed	Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies.	ZNF423 ANKFN1	3.59e-05	3	121	2	26131556
Pubmed	Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts.	PSAP PAK2	3.59e-05	3	121	2	15047825
Pubmed	An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20.	NCAM1 TTC12	3.59e-05	3	121	2	34285142
Pubmed	Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.	PPP3CA CABIN1	3.59e-05	3	121	2	9655484
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	3.59e-05	3	121	2	8643460
Pubmed	Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switch.	ZNF423 ZNF521	3.59e-05	3	121	2	24891617
Pubmed	ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies.	ZNF423 ZNF521	3.59e-05	3	121	2	26788497
Pubmed	Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.	MC1R EXOC2	3.59e-05	3	121	2	21700618
Pubmed	Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ.	PSAP GPR37	3.59e-05	3	121	2	37075680
Pubmed	Molecular prognostic profile of Egyptian HCC cases infected with hepatitis C virus.	PPP3CA ABCG2	3.59e-05	3	121	2	23317196
Pubmed	Correlation of IGF1R expression with ABCG2 and CD44 expressions in human osteosarcoma.	IGF1R ABCG2	3.59e-05	3	121	2	29892839
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	EXOSC10 WAPL KIF4A DOCK5 PARP4 IPO9 TLN1 EXOC2 MTREX CNOT1	3.83e-05	582	121	10	20467437
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DENND4A HIVEP1 MYO9A CARMIL1 RFX7 FSIP2 IGF1R IPO9 PIK3C2A PLEKHA5 MTREX CDC25C	4.88e-05	861	121	12	36931259
Pubmed	Defining the membrane proteome of NK cells.	EXOSC10 ATP7B KIF4A OAS2 NCAM1 PARP4 IPO9 NOP14 PIK3C2A MARF1 PLEKHA5 MMS19 EXOC2 CNOT1	5.76e-05	1168	121	14	19946888
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	WAPL POLR1A GPR37 CARMIL1 NBEA MAP3K4 IGF1R PLEKHA5 CNOT1	6.35e-05	497	121	9	36774506
Pubmed	Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.	PAK2 EXOC2	7.17e-05	4	121	2	26350970
Pubmed	An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.	IGF1R PLEKHA5	7.17e-05	4	121	2	23518924
Pubmed	Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.	NCAM1 TTC12	7.17e-05	4	121	2	18828801
Pubmed	Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cells.	IGF1R PLEKHA5	7.17e-05	4	121	2	29401624
Pubmed	Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.	PPP3CA CABIN1	7.17e-05	4	121	2	11714752
Pubmed	Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.	NCAM1 TTC12	7.17e-05	4	121	2	17085484
Pubmed	Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.	NCAM1 TTC12	7.17e-05	4	121	2	17761687
Pubmed	Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry.	EXOSC10 MTREX	7.17e-05	4	121	2	28431250
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	7.17e-05	4	121	2	7592911
Pubmed	Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling.	PSAP GPR37	7.17e-05	4	121	2	37436891
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX16 DENND4A WAPL DOCK5 PARP4 PSME4 MARF1 PLEKHA5 MTREX HPS5	9.57e-05	650	121	10	38777146
Pubmed	Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.	MC1R IFNGR2 GABBR1	1.01e-04	26	121	3	20378664
Pubmed	Tumor Suppressor PTEN Regulates Negatively Sertoli Cell Proliferation, Testis Size, and Sperm Production In Vivo.	IGF1R PLEKHA5	1.19e-04	5	121	2	30576429
Pubmed	Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.	NPY4R2 NPY4R	1.19e-04	5	121	2	7493937
Pubmed	Model-based prediction of human hair color using DNA variants.	MC1R EXOC2	1.19e-04	5	121	2	21197618
Pubmed	Cross-reactivity of anti-programmed death ligand 2 polyclonal antibody in mouse tissues.	NCAM1 HMCN1	1.19e-04	5	121	2	23090063
Pubmed	NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing.	EXOSC10 MTREX	1.19e-04	5	121	2	26166824
Pubmed	Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.	ZNF423 ZNF521	1.19e-04	5	121	2	14630787
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AKAP6 WAPL PSAP ZNF423 HECTD4 ZNF521 CUL9 NBEA FOCAD PPP3CA PTPRK CEP70 PAK2 CABIN1	1.57e-04	1285	121	14	35914814
Pubmed	Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets.	IGF1R PPP3CA	1.78e-04	6	121	2	20153290
Pubmed	C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase.	DAPK1 CMIP	1.78e-04	6	121	2	20018188
Pubmed	Genetic differences between five European populations.	TLR1 EXOC2	1.78e-04	6	121	2	20616560
Pubmed	C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing.	EXOSC10 MTREX	1.78e-04	6	121	2	17412707
Pubmed	How HIV takes advantage of the cytoskeleton in entry and replication.	KIF4A PAK2	1.78e-04	6	121	2	21994733
Pubmed	The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.	KRT36 RNF182 CARD14 EPHA1	1.98e-04	82	121	4	25260751
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	POLR1A MYO9A STXBP5L CARMIL1 HECTD4 FBXL17 GRIK2 DOCK5 KLK4 CMIP IGF1R PPP3CA TTC12 HPS5 CNOT1	2.12e-04	1489	121	15	28611215
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	DHX16 IFNGR2 IGF1R PIK3C2A TLR1 ABCG2 CDC25C	2.37e-04	351	121	7	20453000
Pubmed	Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.	GRIK2 PPP3CA	2.49e-04	7	121	2	17428973
Pubmed	Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.	EXOSC10 MTREX	2.49e-04	7	121	2	30538148
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	DHX16 WAPL HIVEP1 ARID4A KIF4A UBR7 FSIP2 NOP14 CABIN1	2.86e-04	608	121	9	36089195
Pubmed	Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.	HECTD4 GRIK2 ABCG2	2.93e-04	37	121	3	22797727
Pubmed	Personal receptor repertoires: olfaction as a model.	OR2S2 OR2F1 OR2T11	3.17e-04	38	121	3	22908908
Pubmed	A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.	MC1R EXOC2	3.32e-04	8	121	2	18483556
Pubmed	GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice.	PSAP GPR37	3.32e-04	8	121	2	31143101
Pubmed	Predictive value of 8 genetic loci for serum uric acid concentration.	CARMIL1 ABCG2	3.32e-04	8	121	2	20162742
Pubmed	Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series.	CARMIL1 ABCG2	3.32e-04	8	121	2	20162743
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	AKAP6 EXOSC10 DENND4A HIVEP1 PSAP PARP4 PIK3C2A TLN1	3.61e-04	497	121	8	23414517
Pubmed	GWAS of dental caries patterns in the permanent dentition.	ELF4 ABCG2 EXOC2	3.98e-04	41	121	3	23064961
Pubmed	Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.	PAK2 EXOC2	4.25e-04	9	121	2	22534017
Pubmed	Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.	ABCA1 NCAM1 PAK2	4.58e-04	43	121	3	21116278
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX16 EXOSC10 POLR1A KIF4A CUL9 NOP14 TLN1 MTREX CNOT1	4.80e-04	653	121	9	22586326
Pubmed	Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.	CARMIL1 ABCG2	5.30e-04	10	121	2	19503597
Pubmed	Genetic determinants of hair, eye and skin pigmentation in Europeans.	MC1R EXOC2	5.30e-04	10	121	2	17952075
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AKAP6 WAPL HECTD4 PSME4 PLEKHA5 MTREX HPS5 CNOT1	5.45e-04	529	121	8	14621295
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	HECTD4 KIF4A DAPK1 NCAM1 NBEA GRIK2 PPP3CA PAK2 PLEKHA5 CABIN1 CNOT1	5.56e-04	963	121	11	28671696
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DHX16 ZNF423 CUL9 MAP3K4 IGDCC4 FOCAD TLN1	5.75e-04	407	121	7	12693553
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	AKAP6 TRA DAPK1 OR2S2 GPR156	5.90e-04	193	121	5	20677014
Pubmed	Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease.	CARMIL1 ABCG2	6.47e-04	11	121	2	19890391
Pubmed	Genome-wide association study of tanning phenotype in a population of European ancestry.	MC1R EXOC2	6.47e-04	11	121	2	19340012
Pubmed	MARF1 regulates essential oogenic processes in mice.	MARF1 CDC25C	6.47e-04	11	121	2	22442484
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	NPR3 NCAM1 NBEA GRIK2 CHRNE GABBR1	6.57e-04	300	121	6	19086053
Pubmed	High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H.	FAAP24 CLDND2 EIF2B3	6.73e-04	49	121	3	24378760
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	DHX16 ABCA1 MYO9A IGF1R PPP3CA CDC25C EPHA1	6.91e-04	420	121	7	28065597
Pubmed	Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells.	CSF1 PIK3C2A	7.74e-04	12	121	2	16514418
Pubmed	Genome-wide association study and meta-analysis of intraocular pressure.	TRA SLC30A8	7.74e-04	12	121	2	24002674
Pubmed	Single nuclei RNA-seq of mouse placental labyrinth development.	NCAM1 IGF1R	7.74e-04	12	121	2	33141023
Pubmed	Three novel components of the human exosome.	EXOSC10 MTREX	7.74e-04	12	121	2	11110791
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	EXOSC10 WAPL IPO9 EIF2B3 MMS19 EXOC2 MTREX CNOT1	7.89e-04	560	121	8	35241646
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	DENND4A MYO9A PPP3CA PLEKHA5 DDHD2	8.44e-04	209	121	5	36779422
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	WAPL PSAP KIF4A CUL9 PSME4	9.00e-04	212	121	5	33853758
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	EXOSC10 WAPL POLR1A HECTD4 MAP3K4 MMS19 MTREX	9.06e-04	440	121	7	34244565
Pubmed	Protein-protein interactions of hCsl4p with other human exosome subunits.	EXOSC10 MTREX	9.13e-04	13	121	2	11812149
Pubmed	Alternative splice variants encoding unstable protein domains exist in the human brain.	FAT2 ABCB9	9.13e-04	13	121	2	15491607
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	FSIP2 ELF4 HPS5 CNOT1	9.20e-04	123	121	4	26912792
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	AKAP6 CUL9 NBEA ZP2 PPP3CA GABBR1	1.06e-03	329	121	6	17474147
Pubmed	Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.	HIVEP1 KCTD17 HMCN1 CNOT1	1.07e-03	128	121	4	25332235
Pubmed	Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor.	PSAP GPR37	1.22e-03	15	121	2	25609427
Pubmed	Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.	MC1R EXOC2	1.22e-03	15	121	2	23548203
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	DHX16 HIVEP1 PSAP ZNF423 ZNF804A UBR7 CEP70 PLEKHA5	1.33e-03	608	121	8	16713569
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	STXBP5L NCAM1 NBEA PPP3CA PIK3C2A GABBR1	1.39e-03	347	121	6	17114649
Pubmed	Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.	ABCA1 ABCG2	1.40e-03	16	121	2	19679677
Pubmed	Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.	NPR3 HECTD4	1.40e-03	16	121	2	21572416
Interaction	MTNR1A interactions	WAPL MYO9A CMIP IPO9 PSME4 TLN1 MMS19 DDHD2	4.70e-06	166	114	8	int:MTNR1A
GeneFamily	Fibronectin type III domain containing	NCAM1 IGDCC4 IFNGR2 IGF1R PTPRK ANKFN1 EPHA1	2.00e-05	160	94	7	555
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND5B NPR3 DENND4A	2.88e-04	25	94	3	504
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	NCAM1 IGDCC4 HMCN1 CD101 ALPK2	1.53e-03	161	94	5	593
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	DENND5B ABCA1 HECTD4 DAPK1 CMIP PTPRK PLEKHA5	7.13e-07	185	120	7	1d874608aa2062024323512f68889219471b2f00
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	NPR3 WAPL ARID4A PARP4 HMCN1 PIK3C2A MARF1	7.39e-07	186	120	7	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	NPR3 ZNF423 ZNF521 DAPK1 CMIP HMCN1 PIK3C2A	9.15e-07	192	120	7	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPR3 ZNF423 ZNF521 OAS2 FOCAD ABCG2	8.58e-06	177	120	6	1921226196b2ab7919d9f843e60d9f4bd9ec9c57
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|lymph-node_spleen / Manually curated celltypes from each tissue	NPR3 POLR1A KIF4A UBR7 DOCK5 CDC25C	1.14e-05	186	120	6	17eec1efad1f5e9ced1eb6bc9eb5dd7ded789c61
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ZNF521 IGF1R PIK3C2A ABCG2 TAF4B CABIN1	1.17e-05	187	120	6	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	DENND5B FBXL17 CMIP IGF1R PTPRK PLEKHA5	1.36e-05	192	120	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NPR3 ZNF423 ZNF521 IGF1R HMCN1 PTPRK	1.44e-05	194	120	6	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYO9A DAPK1 DOCK5 PTPRK CEP70 KIAA1958	1.67e-05	199	120	6	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYO9A DAPK1 DOCK5 PTPRK CEP70 KIAA1958	1.67e-05	199	120	6	5cea0d9e261903e0eaad60c28a07dff72ce65027
Disease	adiponectin measurement	FBXL17 CMIP CSF1 ABCB9 PTPRK HPS5	2.28e-05	146	114	6	EFO_0004502
Disease	vesicoureteral reflux (is_marker_for)	IGF1R CSF1	1.47e-04	5	114	2	DOID:9620 (is_marker_for)
Disease	immunoglobulin superfamily DCC subclass member 4 measurement	DENND4A IGDCC4	1.47e-04	5	114	2	EFO_0801690
Disease	adenosine measurement	AKAP6 ZNF804A	2.20e-04	6	114	2	EFO_0010453
Disease	toxic encephalopathy (is_implicated_in)	IGF1R ABCG2	2.20e-04	6	114	2	DOID:3602 (is_implicated_in)
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	AKAP6 HIVEP1 ARID4A ZNF423 FBXL17 NCAM1 NBEA IGF1R PTPRK PLEKHA5 HPS5	2.80e-04	801	114	11	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	thalamus volume	OAS2 NCAM1 RFX7 PLEKHA5	3.36e-04	85	114	4	EFO_0006935
Disease	mean corpuscular hemoglobin concentration	DENND4A ATP7B POLR1A ARID4A CARMIL1 HECTD4 FBXL17 KCTD17 IGDCC4 FOCAD PAK2 EXOC2 RNF182	3.48e-04	1105	114	13	EFO_0004528
Disease	schizophrenia, intelligence, self reported educational attainment	AKAP6 DENND5B DENND4A CARMIL1 FBXL17 NCAM1 ZNF804A	4.04e-04	346	114	7	EFO_0004337, EFO_0004784, MONDO_0005090
Disease	lymphocyte count	HIVEP1 MANBA PCDHGA11 HECTD4 SLC30A8 UROC1 RFX7 FOCAD CMIP CSF1 PSME4 TLN1 PAK2 ADGRD2 DDHD2	5.20e-04	1464	114	15	EFO_0004587
Disease	Headache, glucose measurement	MANBA IGF1R	5.23e-04	9	114	2	EFO_0004468, HP_0002315
Disease	Congenital myasthenic syndrome	MYO9A CHRNE	6.52e-04	10	114	2	cv:C0751882
Disease	coronary artery disease	ABCA1 NPR3 PSAP ARID4A CARMIL1 HECTD4 FBXL17 DOCK5 AP4E1 CMIP ABCG2 CABIN1 GABBR1	7.19e-04	1194	114	13	EFO_0001645
Disease	age at first sexual intercourse measurement	AKAP6 ARID4A ZNF423 ZNF521 NCAM1 ZNF804A PLEKHA5	7.36e-04	383	114	7	EFO_0009749
Disease	imidazole lactate measurement	HPS5 CNOT1	1.12e-03	13	114	2	EFO_0800004
Disease	glucose-dependent insulinotropic peptide measurement	NBEA ABCB9 EXOC2	1.14e-03	53	114	3	EFO_0008464
Disease	plasminogen activator inhibitor 1 measurement	RFX7 MAP3K4 MUC17	1.21e-03	54	114	3	EFO_0004792
Disease	Peripheral Nervous System Diseases	ABCA1 DAPK1 IGF1R	1.21e-03	54	114	3	C4721453
Disease	diffuse idiopathic skeletal hyperostosis	SLC30A8 ANKFN1	1.50e-03	15	114	2	EFO_0007236
Disease	Intellectual Disability	AKAP6 KIF4A NBEA UROC1 UBR7 AP4E1 ZNF526	1.79e-03	447	114	7	C3714756
Disease	Profound Mental Retardation	UROC1 UBR7 AP4E1 ZNF526	2.11e-03	139	114	4	C0020796
Disease	Mental Retardation, Psychosocial	UROC1 UBR7 AP4E1 ZNF526	2.11e-03	139	114	4	C0025363
Disease	Mental deficiency	UROC1 UBR7 AP4E1 ZNF526	2.11e-03	139	114	4	C0917816
Disease	autoimmune thyroid disease, type 1 diabetes mellitus	BCL2L15 QRFPR	2.17e-03	18	114	2	EFO_0006812, MONDO_0005147
Disease	Lewy body dementia (is_marker_for)	GPR37 IGF1R	2.42e-03	19	114	2	DOID:12217 (is_marker_for)
Disease	skin sensitivity to sun	MC1R ADAMTS12	2.42e-03	19	114	2	EFO_0004795
Disease	Phenyllactate (PLA) measurement	DAPK1 CNOT1	2.42e-03	19	114	2	EFO_0021662
Disease	limited scleroderma	TLR1 EXOC2	2.42e-03	19	114	2	EFO_1001017
Disease	urate measurement	ABCA1 MYO9A FAAP24 CARMIL1 HECTD4 AP4E1 CMIP IGF1R ABCG2 DDHD2	2.50e-03	895	114	10	EFO_0004531
Disease	freckles	MC1R EXOC2	2.69e-03	20	114	2	EFO_0003963
Disease	waist-hip ratio	ABCA1 NPR3 ARID4A ZNF423 HECTD4 CUL9 NCAM1 RFX7 CMIP IGF1R ABCB9 TTC12	2.81e-03	1226	114	12	EFO_0004343
Disease	alcohol consumption measurement	AKAP6 WAPL ARID4A ZNF521 FAM114A2 NCAM1 NBEA ZNF804A IPO9 PTPRK TTC12 KLF18	3.12e-03	1242	114	12	EFO_0007878
Disease	atrial fibrillation	AKAP6 LRRC63 MANBA IGF1R PAK2 ADGRD2	3.24e-03	371	114	6	EFO_0000275
Disease	mean arterial pressure	NPR3 ZNF423 HECTD4 DAPK1 NCAM1 CMIP PPP3CA	3.30e-03	499	114	7	EFO_0006340
Disease	body weight	AKAP6 NPR3 HIVEP1 POLR1A ZNF423 HECTD4 ZNF521 FBXL17 GRIK2 QRFPR IGF1R IPO9	3.52e-03	1261	114	12	EFO_0004338
Disease	insulin sensitivity measurement	IFNGR2 CSF1	3.55e-03	23	114	2	EFO_0004471
Disease	intraocular pressure measurement	EXOSC10 ABCA1 SLC30A8 FBXL17 CHRNE EXOC2 CDC25C	3.68e-03	509	114	7	EFO_0004695
Disease	Hepatolenticular Degeneration	ATP7B PPP3CA	3.86e-03	24	114	2	C0019202
Disease	Hepatic Form of Wilson Disease	ATP7B PPP3CA	3.86e-03	24	114	2	C1527352

Protein segments in the cluster

Peptide	Gene	Start	Entry
TMECVLELTAEDLTQ	EPHA1	941	P21709
LLDSVCSTIENVMAT	DAPK1	1211	P53355
EMTNTVSQERTSDCI	ARID4A	876	P29374
QVQETVRETISCSQM	ALPK2	656	Q86TB3
QVATSTVRILGMTCQ	ATP7B	56	P35670
QQLSEVALMTTSVDV	ABCA1	1641	O95477
VALMTTSVDVLVSIC	ABCA1	1646	O95477
QSVVSVATLLMTICF	ABCG2	531	Q9UNQ0
TMLQVLNLCETPVTD	CMIP	711	Q8IY22
CSEEILTVAAMLSVN	DHX16	836	O60231
ALTICNSVMVSTTTE	ATP10B	586	O94823
RTVLCIQTMVSDEQA	ADAMTS12	906	P58397
TLIVMNCVIVLNVSQ	CHRNE	316	Q04844
IQASERVVIMCASSD	NPR3	251	P17342
DLQSTNLVEVCMALT	AP4E1	141	Q9UPM8
NLVEVCMALTVVSQI	AP4E1	146	Q9UPM8
ENTTVVSGQSVVMEC	IGDCC4	251	Q8TDY8
MTQNTLAVTDICIII	DENND4A	151	Q7Z401
STAVVTEILTMTCIA	QRFPR	126	Q96P65
TTTMLITVVDVNDNA	PCDHGA11	331	Q9Y5H2
LDNVIDVITCSSMLS	MC1R	116	Q01726
MPTVLQCVNVSVVSE	KLK4	161	Q9Y5K2
QCMSVTVSILSLVLV	NPY4R	121	P50391
IITDGTLCMTQDQIL	ELF4	61	Q99607
QSSDVIAVCQSLRQM	MMS19	591	Q96T76
CLITAPVTMILSSQQ	GABBR1	816	Q9UBS5
MFPVQTITTVDSCVV	HPS5	166	Q9UPZ3
IVASEIIGTLMDQCT	FSIP2	3116	Q5CZC0
IDSVTSAQMLQGCTI	IGF1R	341	P08069
TQEEVCQLSINIMQV	EXOC2	651	Q96KP1
LSDVTTVMVNITDVN	FAT2	3301	Q9NYQ8
TLMGNILIVTVTTCD	OR14C36	36	Q8NHC7
CDVSSTVEIIIMQAL	PIK3C2A	441	O00443
CQTIVDTVASEMNRI	DDHD2	316	O94830
CENMTLVEAIQTVQA	DUSP13	156	Q9UII6
ETITAMTNLAIVNCQ	LRRC63	306	Q05C16
RLACVDTSSNEVTIM	OR2F1	186	Q13607
ADISINVISMEVTNV	OR2S2	191	Q9NQN1
QLIRDMVNVCETNLS	PARP4	351	Q9UKK3
CDEVLEMLQQVTTAL	HECTD4	501	Q9Y4D8
ELQELCQSTLTEMES	NOP14	731	P78316
QTLIDEMVNTICDVL	OAS2	31	P29728
VLQCQEEELTQMVST	KCTD17	146	Q8N5Z5
MTQINCTQVTEFILV	OR8U9	1	P0C7N5
TVSLCDITITQMLEE	CDC25C	261	P30307
TNMTVIVNVQTTLAC	HMCN1	3811	Q96RW7
LTDVVTETCMDEAQI	PAK2	331	Q13177
TITNCLLMNSVTVEE	EIF2B3	386	Q9NR50
TCLMQISTRTEDFII	EXOSC10	326	Q01780
QVMLTNTFDLSCVVR	CD101	551	Q93033
LESQMNCTVVALTIL	GPR37	486	O15354
CTEMLQSSTAIQVEA	CABIN1	641	Q9Y6J0
IALIQDMTQQCTVTR	CARD14	746	Q9BXL6
TMELTNERISNCVQQ	DOCK5	1521	Q9H7D0
LQRLIDSQMETSCQI	CSF1	51	P09603
ETSCQQNMIQELIET	CEP70	76	Q8NHQ1
TEQEETIASLQMEVC	CEP70	166	Q8NHQ1
QNIIEINISDCRSMS	FBXL17	386	Q9UF56
SQMEASCLVIQLVQE	FAAP24	121	Q9BTP7
EEVTSKQICTAMQTL	DENND5B	121	Q6ZUT9
IERSQTLSQMTIVLC	FAM114A2	411	Q9NRY5
LTQVMQAQCVKTETE	MANBA	621	O00462
DTTICLSQQDNEMVI	MARF1	1231	Q9Y4F3
TADIMSIGVNCTQIT	IFNGR2	76	P38484
SSEVLNLVMETLCIV	IPO9	576	Q96P70
TDPIQCLQILSVSMT	GPR156	186	Q8NFN8
QLITQLSDETVACMA	KIF4A	471	O95239
TSTSNQTLCEEQVMT	KLF18	646	A0A0U1RQI7
STSCIGTELNTVNVM	CUL9	1241	Q8IWT3
GIVTSTTQQMIDRIC	CARMIL1	681	Q5VZK9
LMESTTIEFVTQRNC	GRIK2	736	Q13002
MSTTTCQVVAFLLSI	CLDN18	1	P56856
VTEMLVNVLNICSDD	PPP3CA	361	Q08209
TQMSLQLLCVSEVSL	FOCAD	266	Q5VW36
QLCLEIMVTQAQSSQ	FOCAD	1426	Q5VW36
MQCLISNVEAQLSEI	KRT36	351	O76013
EQSACIVMVTNLVEV	PTPRK	976	Q15262
ICFTSTTVPQMVVNI	OR1C1	71	Q15619
SQLSIMDTLFICTTV	OR2T11	61	Q8NH01
CSDITINVLIMTVTN	OR13D1	221	Q8NGV5
TVCGNMLIVVTITSS	OR4C3	36	Q8NH37
ITKVTTQQIMINDIC	MUC17	4276	Q685J3
QSSDQVIVCIMGTVS	MROH5	1091	Q6ZUA9
IEGLMTLCQEQTSSQ	MAP3K4	966	Q9Y6R4
IQQCVQQTSSDMVIA	TAF4B	341	Q92750
TVNTMQISCLLGQIE	POLR1A	906	O95602
IIQDAESITCMTELL	NBEA	111	Q8NFP9
QLCIAEFSTVLMEVQ	MSH4	256	O15457
SNCLVITIMEVQRES	RNF182	126	Q8N6D2
TMADQIVTVCATLDE	STXBP3	176	O00186
ETSFILQANVVVMCS	STXBP5L	976	Q9Y2K9
SCNITLLIVTIVATM	TLR1	576	Q15399
SMDQFSTAVVIVCLL	ABCB9	221	Q9NP78
TFEEQTECIVNTLLM	BCL2L15	6	Q5TBC7
DVNVSMIVNVSCTSA	AKAP6	1731	Q13023
NTCILARVVMITVSS	ADGRD2	816	Q7Z7M1
EIIMDNLQTLRCTIT	ANKFN1	321	Q8N957
QTTLAVTVACMVLAV	CLDND2	56	Q8NHS1
LSETILTMVANCSNV	CNOT1	666	A5YKK6
QTAMELEEQVTLTCE	NCAM1	316	P13591
TVMIIVSSCAVAANI	SLC30A8	176	Q8IWU4
MLSLVLTVCVSQTQA	TMC8	606	Q8IU68
ICIMDAENITTVSVI	WDR88	211	Q6ZMY6
VTINPTASCLVMTTE	MTREX	216	P42285
VISTCLEFSMAQTVT	TRA	11	P0DTU3
ICQTMQENSTLVVTL	UROC1	646	Q96N76
AVTDSINQLITMCTQ	TLN1	1341	Q9Y490
RCVVCMQTVTSTLEL	ZNF521	1021	Q96K83
SLVEDLTQMCQQEVL	ZSCAN1	111	Q8NBB4
LTQMCQQEVLVSLDS	ZSCAN1	116	Q8NBB4
LSVCNVTIQDTMERS	WAPL	366	Q7Z5K2
QCMSVTVSILSLVLV	NPY4R2	121	P0DQD5
VVSVMVLTVLCNVAE	TMCO6	396	Q96DC7
SASCEQQQDISVMTI	RFX7	696	Q2KHR2
CIQMVTDIQTAVRTN	PSAP	201	P07602
CSVITQLTMNDDVLN	PSME4	651	Q14997
LSSMNRVQQVELICE	UBR7	361	Q8N806
VISTCLEFSMAQTVT	TRAV38-2DV8	11	A0JD32
IEILTEMINECTEQT	TTC12	266	Q9H892
QTIMCTELGETIAII	ZNF526	621	Q8TF50
RCVVCMQTVTSTLEL	ZNF423	1021	Q2M1K9
NCIFVVNEQTVATMT	PLEKHA5	96	Q9HAU0
MQVEETQGLSASTIC	ZP2	141	Q05996
TASEQINCTQTSMEV	HIVEP1	1366	P15822
TVLDMSNDCISVQAT	ZNF804A	361	Q7Z570
SQTQMVDECSNDVII	KIAA1958	186	Q8N8K9
TTTCVELIVVEQMNK	MYO9A	2236	B2RTY4