Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 RORC ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	2.48e-05	1412	49	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 RORC ZNF101 ZNF565 ZNF664 ZNF99	3.47e-05	1244	49	12	GO:0000978
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 RORC ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	3.50e-05	1459	49	13	GO:0000977
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 RORC ZNF101 ZNF565 ZNF664 ZNF99	4.28e-05	1271	49	12	GO:0000987
GeneOntologyMolecularFunction	kinase activity	PIK3R4 CAD LATS1 PIM2 TRIO KALRN DGKK PPIP5K1 NUAK2	8.71e-05	764	49	9	GO:0016301
GeneOntologyMolecularFunction	protein serine kinase activity	PIK3R4 LATS1 PIM2 TRIO KALRN NUAK2	2.50e-04	363	49	6	GO:0106310
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	PIK3R4 CAD LATS1 PIM2 TRIO KALRN DGKK NUAK2	3.02e-04	709	49	8	GO:0016773
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PIK3R4 CAD LATS1 PIM2 TRIO KALRN DGKK PPIP5K1 NUAK2	4.04e-04	938	49	9	GO:0016772
GeneOntologyMolecularFunction	protein kinase activity	PIK3R4 CAD LATS1 PIM2 TRIO KALRN NUAK2	6.13e-04	600	49	7	GO:0004672
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	PIK3R4 LATS1 PIM2 TRIO KALRN NUAK2	7.45e-04	446	49	6	GO:0004674
GeneOntologyMolecularFunction	retinoic acid binding	UGT1A8 UGT1A9	2.14e-03	28	49	2	GO:0001972
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT1A8 UGT1A9	3.33e-03	35	49	2	GO:0015020
GeneOntologyMolecularFunction	steroid binding	UGT1A8 UGT1A9 RORC	4.26e-03	133	49	3	GO:0005496
GeneOntologyMolecularFunction	FAD binding	AOX1 D2HGDH	5.23e-03	44	49	2	GO:0071949
GeneOntologyMolecularFunction	retinoid binding	UGT1A8 UGT1A9	6.19e-03	48	49	2	GO:0005501
GeneOntologyMolecularFunction	isoprenoid binding	UGT1A8 UGT1A9	6.45e-03	49	49	2	GO:0019840
GeneOntologyBiologicalProcess	xenobiotic metabolic process	CAD UGT1A8 AOX1 UGT1A9 RORC	2.08e-05	141	49	5	GO:0006805
GeneOntologyBiologicalProcess	estrogen catabolic process	UGT1A8 UGT1A9	5.50e-05	5	49	2	GO:0006711
GeneOntologyBiologicalProcess	flavonoid glucuronidation	UGT1A8 UGT1A9	5.50e-05	5	49	2	GO:0052696
GeneOntologyBiologicalProcess	phenylpropanoid catabolic process	UGT1A8 UGT1A9	8.24e-05	6	49	2	GO:0046271
GeneOntologyBiologicalProcess	coumarin catabolic process	UGT1A8 UGT1A9	8.24e-05	6	49	2	GO:0046226
GeneOntologyBiologicalProcess	flavone metabolic process	UGT1A8 UGT1A9	8.24e-05	6	49	2	GO:0051552
GeneOntologyBiologicalProcess	retinoic acid metabolic process	UGT1A8 UGT1A9 SCPEP1	1.17e-04	40	49	3	GO:0042573
GeneOntologyBiologicalProcess	cellular response to xenobiotic stimulus	CAD UGT1A8 AOX1 UGT1A9 RORC	1.79e-04	222	49	5	GO:0071466
GeneOntologyBiologicalProcess	phenylpropanoid metabolic process	UGT1A8 UGT1A9	2.46e-04	10	49	2	GO:0009698
GeneOntologyBiologicalProcess	coumarin metabolic process	UGT1A8 UGT1A9	2.46e-04	10	49	2	GO:0009804
GeneOntologyBiologicalProcess	xenobiotic glucuronidation	UGT1A8 UGT1A9	3.59e-04	12	49	2	GO:0052697
GeneOntologyBiologicalProcess	isoprenoid metabolic process	UGT1A8 UGT1A9 SCPEP1 ALG1	3.78e-04	144	49	4	GO:0006720
GeneOntologyBiologicalProcess	flavonoid metabolic process	UGT1A8 UGT1A9	4.24e-04	13	49	2	GO:0009812
Domain	-	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	1.01e-07	679	48	12	3.30.160.60
Domain	zf-C2H2	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	1.26e-07	693	48	12	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	1.28e-07	694	48	12	IPR013087
Domain	KRAB	ZNF17 ZNF547 ZNF789 ZNF257 ZFP14 ZNF57 ZNF101 ZNF565 ZNF99	2.74e-07	358	48	9	PS50805
Domain	KRAB	ZNF17 ZNF547 ZNF789 ZNF257 ZFP14 ZNF57 ZNF101 ZNF565 ZNF99	2.74e-07	358	48	9	PF01352
Domain	KRAB	ZNF17 ZNF547 ZNF789 ZNF257 ZFP14 ZNF57 ZNF101 ZNF565 ZNF99	3.54e-07	369	48	9	SM00349
Domain	KRAB	ZNF17 ZNF547 ZNF789 ZNF257 ZFP14 ZNF57 ZNF101 ZNF565 ZNF99	3.62e-07	370	48	9	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	4.21e-07	775	48	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	4.33e-07	777	48	12	PS00028
Domain	Znf_C2H2-like	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	5.59e-07	796	48	12	IPR015880
Domain	Znf_C2H2	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	6.30e-07	805	48	12	IPR007087
Domain	ZnF_C2H2	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	6.56e-07	808	48	12	SM00355
Domain	Spectrin	SPTBN5 TRIO KALRN	2.72e-05	23	48	3	PF00435
Domain	Spectrin_repeat	SPTBN5 TRIO KALRN	5.55e-05	29	48	3	IPR002017
Domain	-	AOX1 D2HGDH	6.44e-05	5	48	2	3.30.43.10
Domain	FAD-bd_2_sub1	AOX1 D2HGDH	6.44e-05	5	48	2	IPR016167
Domain	Spectrin/alpha-actinin	SPTBN5 TRIO KALRN	7.50e-05	32	48	3	IPR018159
Domain	SPEC	SPTBN5 TRIO KALRN	7.50e-05	32	48	3	SM00150
Domain	FAD_PCMH	AOX1 D2HGDH	9.64e-05	6	48	2	PS51387
Domain	CO_DH_flavot_FAD-bd_sub2	AOX1 D2HGDH	9.64e-05	6	48	2	IPR016169
Domain	FAD-bd_2	AOX1 D2HGDH	9.64e-05	6	48	2	IPR016166
Domain	-	AOX1 D2HGDH	9.64e-05	6	48	2	3.30.465.10
Domain	Ser/Thr_kinase_AS	PIK3R4 LATS1 PIM2 TRIO KALRN NUAK2	2.92e-04	357	48	6	IPR008271
Domain	S_TKc	PIK3R4 LATS1 PIM2 TRIO KALRN NUAK2	3.00e-04	359	48	6	SM00220
Domain	PROTEIN_KINASE_ST	PIK3R4 LATS1 PIM2 TRIO KALRN NUAK2	3.14e-04	362	48	6	PS00108
Domain	Pkinase	PIK3R4 LATS1 PIM2 TRIO KALRN NUAK2	4.12e-04	381	48	6	PF00069
Domain	PROTEIN_KINASE_ATP	PIK3R4 LATS1 PIM2 TRIO KALRN NUAK2	1.09e-03	459	48	6	PS00107
Domain	zf-C2H2_6	ZNF17 ZNF789 ZSCAN9 ZFP14 ZNF99	1.23e-03	314	48	5	PF13912
Domain	UDPGT	UGT1A8 UGT1A9	1.32e-03	21	48	2	PS00375
Domain	UDPGT	UGT1A8 UGT1A9	1.32e-03	21	48	2	PF00201
Domain	CRAL_TRIO	TRIO KALRN	1.32e-03	21	48	2	PF00650
Domain	UDP_glucos_trans	UGT1A8 UGT1A9	1.32e-03	21	48	2	IPR002213
Domain	Prot_kinase_dom	PIK3R4 LATS1 PIM2 TRIO KALRN NUAK2	1.51e-03	489	48	6	IPR000719
Domain	PROTEIN_KINASE_DOM	PIK3R4 LATS1 PIM2 TRIO KALRN NUAK2	1.57e-03	493	48	6	PS50011
Domain	-	TRIO KALRN	1.58e-03	23	48	2	3.40.525.10
Domain	SEC14	TRIO KALRN	1.87e-03	25	48	2	SM00516
Domain	CRAL_TRIO	TRIO KALRN	2.18e-03	27	48	2	PS50191
Domain	SH3	TRIO KALRN SH3GLB2 HCLS1	2.27e-03	216	48	4	PS50002
Domain	SH3	TRIO KALRN SH3GLB2 HCLS1	2.27e-03	216	48	4	SM00326
Domain	CRAL-TRIO_dom	TRIO KALRN	2.34e-03	28	48	2	IPR001251
Domain	SH3_domain	TRIO KALRN SH3GLB2 HCLS1	2.43e-03	220	48	4	IPR001452
Domain	Kinase-like_dom	PIK3R4 LATS1 PIM2 TRIO KALRN NUAK2	2.53e-03	542	48	6	IPR011009
Domain	PH	SPTBN5 TRIO KALRN DGKK	2.81e-03	229	48	4	PF00169
Pathway	WP_NICOTINE_METABOLISM_IN_LIVER_CELLS	AOX1 UGT1A9	8.93e-05	6	35	2	M39600
Pubmed	Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors.	UGT1A8 UGT1A9	1.94e-06	2	49	2	18568343
Pubmed	Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.	TRIO KALRN	1.94e-06	2	49	2	26858404
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF17 ZNF789 ZNF257 ZNF57 ZNF101	5.72e-06	181	49	5	37372979
Pubmed	UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients.	UGT1A8 UGT1A9	5.83e-06	3	49	2	19225446
Pubmed	Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.	TRIO KALRN	5.83e-06	3	49	2	31801062
Pubmed	Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.	UGT1A8 UGT1A9	5.83e-06	3	49	2	29519853
Pubmed	Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1α and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid.	UGT1A8 UGT1A9	5.83e-06	3	49	2	23721685
Pubmed	p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4.	CKAP4 DKK3	5.83e-06	3	49	2	30181180
Pubmed	Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9.	UGT1A8 UGT1A9	5.83e-06	3	49	2	26247833
Pubmed	Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.	UGT1A8 UGT1A9	5.83e-06	3	49	2	16397224
Pubmed	Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region.	UGT1A8 UGT1A9	5.83e-06	3	49	2	12847094
Pubmed	Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.	LATS1 NUAK2	5.83e-06	3	49	2	19927127
Pubmed	The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers.	UGT1A8 UGT1A9	5.83e-06	3	49	2	17339869
Pubmed	Influence of uridine diphosphate (UDP)-glucuronosyltransferases and ABCC2 genetic polymorphisms on the pharmacokinetics of mycophenolic acid and its metabolites in Chinese renal transplant recipients.	UGT1A8 UGT1A9	1.16e-05	4	49	2	18946804
Pubmed	Population pharmacokinetics and pharmacogenetics of mycophenolic acid following administration of mycophenolate mofetil in de novo pediatric renal-transplant patients.	UGT1A8 UGT1A9	1.16e-05	4	49	2	20147615
Pubmed	Genetic polymorphisms of UGT1A8, UGT1A9, UGT2B7 and ABCC2 in Chinese renal transplant recipients and a comparison with other ethnic populations.	UGT1A8 UGT1A9	1.16e-05	4	49	2	23700788
Pubmed	Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets.	RORC DKK3	1.16e-05	4	49	2	23995235
Pubmed	Centrosome-related genes, genetic variation, and risk of breast cancer.	LATS1 CDC25C CNTROB NIN	1.33e-05	102	49	4	20508983
Pubmed	Assembly of high order G alpha q-effector complexes with RGS proteins.	TRIO KALRN	1.94e-05	5	49	2	18936096
Pubmed	Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele.	UGT1A8 UGT1A9	1.94e-05	5	49	2	20565459
Pubmed	Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.	UGT1A8 UGT1A9	1.94e-05	5	49	2	15057901
Pubmed	Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes.	UGT1A8 UGT1A9	2.91e-05	6	49	2	20297805
Pubmed	Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.	UGT1A8 UGT1A9	2.91e-05	6	49	2	32527940
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	LATS1 SH3GLB2 CDC25C CNTROB XPR1 NIN	3.77e-05	446	49	6	24255178
Pubmed	Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.	UGT1A8 UGT1A9	4.07e-05	7	49	2	8467709
Pubmed	Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).	UGT1A8 UGT1A9	4.07e-05	7	49	2	8464825
Pubmed	Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.	UGT1A8 UGT1A9	4.07e-05	7	49	2	27514509
Pubmed	Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.	UGT1A8 UGT1A9	5.42e-05	8	49	2	17179145
Pubmed	Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.	UGT1A8 UGT1A9	5.42e-05	8	49	2	20610558
Pubmed	Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.	UGT1A8 UGT1A9	5.42e-05	8	49	2	12695355
Pubmed	Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.	UGT1A8 UGT1A9	5.42e-05	8	49	2	18052087
Pubmed	A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.	UGT1A8 UGT1A9	6.96e-05	9	49	2	22511988
Pubmed	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.	UGT1A8 UGT1A9	6.96e-05	9	49	2	1339448
Pubmed	Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.	UGT1A8 UGT1A9	6.96e-05	9	49	2	20732626
Pubmed	Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.	UGT1A8 UGT1A9	8.69e-05	10	49	2	23642732
Pubmed	UDP-glucuronosyltransferases.	UGT1A8 UGT1A9	8.69e-05	10	49	2	11465080
Pubmed	A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.	UGT1A8 UGT1A9	8.69e-05	10	49	2	23371916
Pubmed	A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.	UGT1A8 UGT1A9	8.69e-05	10	49	2	22558097
Pubmed	Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients.	UGT1A8 UGT1A9	1.06e-04	11	49	2	18695635
Pubmed	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	UGT1A8 AOX1 UGT1A9	1.13e-04	66	49	3	19898482
Pubmed	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	UGT1A8 UGT1A9	1.27e-04	12	49	2	19419973
Pubmed	Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.	UGT1A8 UGT1A9	1.27e-04	12	49	2	20308471
Pubmed	Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.	LATS1 OGDH	1.27e-04	12	49	2	25438054
Pubmed	Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.	UGT1A8 UGT1A9	1.27e-04	12	49	2	11434514
Pubmed	TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids.	TRIM66 ZNF101	1.50e-04	13	49	2	15322135
Pubmed	UGT1A1 is a major locus influencing bilirubin levels in African Americans.	UGT1A8 UGT1A9	1.50e-04	13	49	2	22085899
Pubmed	Genome-wide analysis of hepatic lipid content in extreme obesity.	UGT1A8 UGT1A9	1.50e-04	13	49	2	25246029
Pubmed	Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.	UGT1A8 UGT1A9	1.75e-04	14	49	2	21646302
Pubmed	Human UDP-glucuronosyltransferases: metabolism, expression, and disease.	UGT1A8 UGT1A9	1.75e-04	14	49	2	10836148
Pubmed	Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.	UGT1A8 UGT1A9	1.75e-04	14	49	2	14672974
Pubmed	The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.	UGT1A8 UGT1A9	1.75e-04	14	49	2	9295054
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF101 ZNF99	2.30e-04	16	49	2	8467795
Pubmed	Genome-wide association meta-analysis for total serum bilirubin levels.	UGT1A8 UGT1A9	2.30e-04	16	49	2	19414484
Pubmed	Genome-wide association of serum bilirubin levels in Korean population.	UGT1A8 UGT1A9	2.61e-04	17	49	2	20639394
Pubmed	Wnt signaling in the murine diastema.	WNT10B DKK3	2.61e-04	17	49	2	21531785
Pubmed	Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.	UGT1A8 UGT1A9	2.93e-04	18	49	2	20056724
Pubmed	A genome-wide assessment of variability in human serum metabolism.	UGT1A8 UGT1A9	3.27e-04	19	49	2	23281178
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	CAD PPIP5K1 TEX15 OGDH	3.34e-04	234	49	4	36243803
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	CNTROB CEP55 NIN	3.97e-04	101	49	3	24613305
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PIK3R4 TRIM66 ZBTB38 TRIO KALRN SH3GLB2 ZNF565 DKK3	3.98e-04	1285	49	8	35914814
Pubmed	Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells.	WNT10B DKK3	4.01e-04	21	49	2	19806668
Pubmed	Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.	ATL1 NIN	4.83e-04	23	49	2	24925725
Pubmed	Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.	ATL1 NIN	5.26e-04	24	49	2	24347629
Pubmed	Genetic determinants influencing human serum metabolome among African Americans.	UGT1A8 UGT1A9	5.26e-04	24	49	2	24625756
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CAD TRIO CKAP4 CDC25C CNTROB CEP55 NIN	6.33e-04	1049	49	7	27880917
Pubmed	Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.	CAD CNTROB	6.67e-04	27	49	2	35709258
Pubmed	Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development.	WNT10B DKK3	8.25e-04	30	49	2	15880404
Pubmed	rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.	SH3GLB2 CEP55 NIN	1.07e-03	142	49	3	30217970
Pubmed	Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.	WNT10B DKK3	1.12e-03	35	49	2	19185060
Pubmed	A Novel Interacting Protein SERP1 Regulates the N-Linked Glycosylation and Function of GLP-1 Receptor in the Liver.	UGT1A9 ZNF99	1.12e-03	35	49	2	28597972
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	CNTROB CEP55 NIN	1.16e-03	146	49	3	21399614
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	ZNF17 TRIO KALRN	1.28e-03	151	49	3	17043677
Cytoband	2p22-p21	CAD NLRC4	3.11e-05	8	49	2	2p22-p21
Cytoband	14q22.1	ATL1 NIN	4.76e-04	30	49	2	14q22.1
Cytoband	2q37	UGT1A8 UGT1A9	5.09e-04	31	49	2	2q37
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	UGT1A8 UGT1A9 D2HGDH	1.84e-03	226	49	3	chr2q37
Cytoband	19q13.12	ZFP14 ZNF565	2.72e-03	72	49	2	19q13.12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF17 ZBTB38 ZNF547 ZNF789 ZNF257 ZSCAN9 ZFP14 ZNF57 ZNF101 ZNF565 ZNF664 ZNF99	6.29e-10	718	30	12	28
GeneFamily	UDP glucuronosyltransferases	UGT1A8 UGT1A9	1.28e-03	32	30	2	363
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO KALRN	5.34e-03	66	30	2	722
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CPPED1 KALRN WNT10B TEX15 CEP55	3.21e-07	130	49	5	92913960e4367261ba08a405b61a421bc5e18169
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|390C / Donor, Lineage, Cell class and subclass (all cells)	TRIM66 WNT10B RORC ATL1 AFG1L	7.67e-07	155	49	5	98d8432739965dd1ab77c899cb6321f7f05eaa46
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TRIM66 WNT10B RORC ATL1 AFG1L	1.11e-06	167	49	5	6c2dade24a88af04b2c90a7e4f8dd7ccea9e94d1
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	TRIM66 WNT10B RORC ATL1 AFG1L	1.14e-06	168	49	5	d8f485f8459532a2cb0bef899e6569142cf75685
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF17 KALRN ZNF565 CNTROB	2.61e-05	156	49	4	84f01419d8c116714e8c8c857c4d153a755b7867
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF17 KALRN ZNF565 CNTROB	2.61e-05	156	49	4	2285be9746d0d0f62a488b9c64fa67a834758dd7
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_activate-7\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPIP5K1 CNTROB NUAK2 AFG1L	4.18e-05	176	49	4	dde46f06f6fc3f7ba83be91a0ee6231790955e3e
ToppCell	facs-Heart-LV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIM2 WNT10B NUAK2 AFG1L	4.66e-05	181	49	4	8855812c85ef45c1be6bd511619b2dfe5e441264
ToppCell	facs-Heart-LV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIM2 WNT10B NUAK2 AFG1L	4.66e-05	181	49	4	57f82f54e20e19aa17a2ea22af22e3bc8965d622
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DGKK CDC25C CNTROB CEP55	4.76e-05	182	49	4	bc6a120dedc813c58baac1428c39851a07b71ba7
ToppCell	facs-Heart-LV-18m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIM2 WNT10B NUAK2 AFG1L	4.76e-05	182	49	4	d0d18dd5d8b2d21e42c3c4259f824c91f24a54bc
Drug	Z 338	UGT1A8 UGT1A9	4.54e-06	2	49	2	ctd:C410959
Drug	Benzamidoxime hydrochloride	UGT1A8 AOX1 UGT1A9	1.21e-05	21	49	3	CID000069186
Drug	phenanthridine	UGT1A8 AOX1 UGT1A9	1.61e-05	23	49	3	CID000009189
Drug	methoxyethane	LATS1 TRIO CDC25C	2.35e-05	26	49	3	CID000010903
Drug	Thymol	UGT1A8 UGT1A9 OGDH	2.35e-05	26	49	3	ctd:D013943
Drug	trans-3'-hydroxycotinine	UGT1A8 AOX1 UGT1A9	3.29e-05	29	49	3	CID000000414
Drug	naringenin chalcone	UGT1A8 UGT1A9	4.52e-05	5	49	2	ctd:C027329
Drug	anthrarobin	UGT1A8 UGT1A9	4.52e-05	5	49	2	ctd:C032186
Drug	1,2,5,8-tetrahydroxy anthraquinone	UGT1A8 UGT1A9	6.77e-05	6	49	2	ctd:C543211
Drug	alloin	UGT1A8 UGT1A9	6.77e-05	6	49	2	ctd:C006457
Drug	2',5'-dihydroxychalcone	UGT1A8 UGT1A9	6.77e-05	6	49	2	ctd:C107497
Drug	formononetin	UGT1A8 UGT1A9 RORC	7.49e-05	38	49	3	ctd:C007768
Drug	acacetin	UGT1A8 UGT1A9 CDC25C	7.49e-05	38	49	3	CID005280442
Drug	T8 0	AOX1 XPR1	9.46e-05	7	49	2	CID000446897
Drug	2',4'-dihydroxychalcone	UGT1A8 UGT1A9	9.46e-05	7	49	2	ctd:C059354
Drug	2-methoxyestradiol	UGT1A8 UGT1A9 CDC25C	1.01e-04	42	49	3	ctd:C022830
Drug	androsterone glucuronide	UGT1A8 AOX1 UGT1A9	1.09e-04	43	49	3	CID000114833
Drug	1,4-dihydroxyanthraquinone	UGT1A8 UGT1A9	1.26e-04	8	49	2	ctd:C034890
Drug	glabridin	UGT1A8 UGT1A9	1.26e-04	8	49	2	ctd:C107601
Drug	AC1MRQNQ	UGT1A8 UGT1A9	1.62e-04	9	49	2	CID003522271
Drug	DHPASiU	UGT1A8 UGT1A9	1.62e-04	9	49	2	CID000197602
Drug	Chebi:32663	UGT1A8 UGT1A9	1.62e-04	9	49	2	CID005460873
Drug	3-iodophenol	UGT1A8 UGT1A9	1.62e-04	9	49	2	CID000012272
Drug	AC1L4J7U	UGT1A8 UGT1A9	1.62e-04	9	49	2	CID000186631
Disease	blood 4-oxo-retinoic acid measurement	UGT1A8 UGT1A9	7.77e-06	3	48	2	EFO_0022216
Disease	indole-3-carboxylate measurement	UGT1A8 UGT1A9	7.77e-06	3	48	2	EFO_0800043
Disease	neuroblastoma, cutaneous melanoma	CPPED1 UGT1A8 UGT1A9	1.29e-05	28	48	3	EFO_0000389, EFO_0000621
Disease	N-acetyl-4-chlorophenylalanine measurement	UGT1A8 UGT1A9	2.58e-05	5	48	2	EFO_0801060
Disease	5-hydroxyindole sulfate measurement	UGT1A8 UGT1A9	2.58e-05	5	48	2	EFO_0800085
Disease	nuclear receptor subfamily 1 group D member 2 measurement	UGT1A8 UGT1A9	2.58e-05	5	48	2	EFO_0801853
Disease	3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP) measurement	UGT1A8 UGT1A9	3.87e-05	6	48	2	EFO_0800566
Disease	X-21339 measurement	UGT1A8 UGT1A9	5.41e-05	7	48	2	EFO_0800808
Disease	X-11793--oxidized bilirubin measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0021260
Disease	Succinimide measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0022118
Disease	X-24849 measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0800909
Disease	X-11530 measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0021249
Disease	sulfate of piperine metabolite C16H19NO3 (2) measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0801034
Disease	cholelithiasis, bilirubin measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0004570, EFO_0004799
Disease	X-11522 measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0800696
Disease	X-10458 measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0800692
Disease	serum N-desmethylclozapine measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0600043
Disease	plasma clozapine measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0600038
Disease	membrane-associated progesterone receptor component 1 measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0802740
Disease	X-16946 measurement	UGT1A8 UGT1A9	7.21e-05	8	48	2	EFO_0800766
Disease	X-11442 measurement	UGT1A8 UGT1A9	9.26e-05	9	48	2	EFO_0021236
Disease	X-11441 measurement	UGT1A8 UGT1A9	9.26e-05	9	48	2	EFO_0021235
Disease	circulating cell free DNA measurement	UGT1A8 UGT1A9	9.26e-05	9	48	2	EFO_0004739
Disease	sulfate of piperine metabolite C18H21NO3 (3) measurement	UGT1A8 UGT1A9	9.26e-05	9	48	2	EFO_0801037
Disease	testis-specific chromodomain protein Y 1 measurement	UGT1A8 UGT1A9	9.26e-05	9	48	2	EFO_0802127
Disease	sulfate of piperine metabolite C18H21NO3 (1) measurement	UGT1A8 UGT1A9	9.26e-05	9	48	2	EFO_0801036
Disease	bilirubin measurement, response to xenobiotic stimulus	UGT1A8 UGT1A9	9.26e-05	9	48	2	EFO_0004570, GO_0009410
Disease	X-11880 measurement	UGT1A8 UGT1A9	9.26e-05	9	48	2	EFO_0800698
Disease	protein-tyrosine kinase 6 measurement	UGT1A8 UGT1A9	9.26e-05	9	48	2	EFO_0020691
Disease	indoleacetate measurement	UGT1A8 UGT1A9	1.16e-04	10	48	2	EFO_0021015
Disease	X-21448 measurement	UGT1A8 UGT1A9	1.16e-04	10	48	2	EFO_0800816
Disease	UDP-glucuronosyltransferase 1-6 measurement	UGT1A8 UGT1A9	1.16e-04	10	48	2	EFO_0802185
Disease	bilirubin measurement, response to tenofovir	UGT1A8 UGT1A9	1.16e-04	10	48	2	EFO_0004570, EFO_0009279
Disease	X-23974 measurement	UGT1A8 UGT1A9	1.16e-04	10	48	2	EFO_0800867
Disease	pregnenetriol sulfate measurement	UGT1A8 UGT1A9	1.41e-04	11	48	2	EFO_0800586
Disease	plasma N-desmethylclozapine measurement	UGT1A8 UGT1A9	1.41e-04	11	48	2	EFO_0600039
Disease	insomnia, bilirubin measurement	UGT1A8 UGT1A9	1.41e-04	11	48	2	EFO_0004570, EFO_0004698
Disease	histidine betaine (hercynine) measurement	UGT1A8 UGT1A9	1.41e-04	11	48	2	EFO_0800972
Disease	aldosterone measurement	UGT1A8 UGT1A9	1.41e-04	11	48	2	EFO_0010219
Disease	X-21796 measurement	UGT1A8 UGT1A9	1.41e-04	11	48	2	EFO_0800825
Disease	biliverdin measurement	UGT1A8 UGT1A9	1.69e-04	12	48	2	EFO_0021033
Disease	dodecanedioate measurement	UGT1A8 XPR1	1.69e-04	12	48	2	EFO_0021054
Disease	p-cresol glucuronide measurement	UGT1A8 UGT1A9	1.69e-04	12	48	2	EFO_0800079
Disease	retinol dehydrogenase 16 measurement	UGT1A8 UGT1A9	2.00e-04	13	48	2	EFO_0802007
Disease	pregnenetriol disulfate measurement	UGT1A8 UGT1A9	2.00e-04	13	48	2	EFO_0800587
Disease	X-24588 measurement	UGT1A8 UGT1A9	2.00e-04	13	48	2	EFO_0800898
Disease	thyroxine measurement	CPPED1 UGT1A8 UGT1A9	3.39e-04	83	48	3	EFO_0005130
Disease	X-21441 measurement	UGT1A8 UGT1A9	3.47e-04	17	48	2	EFO_0800814
Disease	low density lipoprotein cholesterol measurement, body fat percentage	UGT1A8 UGT1A9	3.47e-04	17	48	2	EFO_0004611, EFO_0007800
Disease	angiopoietin-related protein 1 measurement	UGT1A8 UGT1A9	3.90e-04	18	48	2	EFO_0801382
Disease	etiocholanolone glucuronide measurement	ZNF789 NLRC4	4.35e-04	19	48	2	EFO_0800362
Disease	tissue factor measurement	UGT1A8 UGT1A9	5.34e-04	21	48	2	EFO_0010623
Disease	xanthurenate measurement	UGT1A8 UGT1A9	1.02e-03	29	48	2	EFO_0010551
Disease	response to dolutegravir	UGT1A8 UGT1A9	1.09e-03	30	48	2	EFO_0600017

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLIHQKHFQHIQVCT	ALG1	331	Q9BT22
CVHHVLEEVQQVRRS	CKAP4	126	Q07065
DEHQRRVIQCLQKLH	AFG1L	91	Q8WV93
EKLDRQHVQHQLHVI	CEP55	366	Q53EZ4
HTRIHPVQERIAKCH	AOX1	96	Q06278
RIINLHHHRIAQCHE	DGKK	981	Q5KSL6
RKDQHHHRVEQLTLN	NLRC4	141	Q9NPP4
HVENVLKSHQQRLHR	LATS1	646	O95835
RHRAQTEKHVVLCVS	KCNT1	346	Q5JUK3
QVLDVVHEVLHHQRR	KALRN	506	O60229
HHQDHKTELLRCRSQ	CDC25C	436	P30307
RHHVLHDQNVDKRTC	OGDH	686	Q02218
QHEELQNVRKHIHSC	ATL1	246	Q8WXF7
IARQRHCQHAIVFQH	CPPED1	191	Q9BRF8
HVELHSECVTRRHNK	FBXO40	456	Q9UH90
NNTIHVHREIHKITN	DKK3	106	Q9UBP4
DSEHTRRKHCERHIQ	CNTROB	191	Q8N137
EVSHILRHCHERNLA	D2HGDH	111	Q8N465
HINIHQLRNKVSEEH	HCLS1	51	P14317
RVRSVHHVIEECKQE	NIN	1376	Q8N4C6
SHLVCLCQRHVRHLQ	SCPEP1	291	Q9HB40
IQHCHSRGVVHRDIK	PIM2	151	Q9P1W9
HVNHLRCLHEFVKSQ	SH3GLB2	246	Q9NR46
CHQNRVVHRDLKLEN	NUAK2	166	Q9H093
HKALEAEVHRHQAVC	SPTBN5	681	Q9NRC6
VAHLHEHKSAVNRIR	PIK3R4	986	Q99570
HLSHEERVQHRNIKD	XPR1	116	Q9UBH6
SHLIQHKRIHTRENI	ZNF99	186	A8MXY4
VSQLTHHQRIHTCEK	ZNF565	471	Q8N9K5
CSQHVERLQIFQHLH	RORC	476	P51449
RVRNHIMHLEEHLLC	UGT1A9	206	O60656
TQRSVHICHVARKEE	CAD	1606	P27708
HEIRSHALEKSHQCQ	ZNF101	271	Q8IZC7
TCPAHLHQHQKEQIR	ZNF547	116	Q8IVP9
SLCIHQRVHTKERNH	ZNF664	241	Q8N3J9
REHVRIHTQEQLHKC	ZNF57	436	Q68EA5
CTHLTRHQRLHTAEK	ZFP14	296	Q9HCL3
NRHCNLIRHQKIHTV	ZSCAN9	376	O15535
LSTKRNHEQRHIREH	ZBTB38	1106	Q8NAP3
HKHSRVREEVVNICI	TOGARAM1	481	Q9Y4F4
LHIAVHECQHQLRDQ	WNT10B	76	O00744
ITREHICVHRKNENE	TEX15	416	Q9BXT5
VEHKEHRCRHVEEVL	TRIM66	91	O15016
SCQHRVKARLHHILQ	PPIP5K1	626	Q6PFW1
NSHLIRHQKVHTRER	ZNF17	566	P17021
AEQHRKHLEQCVQLR	TRIO	896	O75962
IRHQVIHSGEKRHKC	ZNF789	301	Q5FWF6
RVRNHIMHLEEHLFC	UGT1A8	206	Q9HAW9
HKRIHIRENSHKCEE	ZNF257	191	Q9Y2Q1