Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ethanol binding	ADH7 ADH1B ADH1C	3.91e-08	6	26	3	GO:0035276
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	ADH7 ADH1B ADH1C	3.90e-06	24	26	3	GO:0004745
GeneOntologyMolecularFunction	alcohol dehydrogenase (NAD+) activity	ADH7 ADH1B ADH1C	4.99e-06	26	26	3	GO:0004022
GeneOntologyMolecularFunction	alcohol dehydrogenase [NAD(P)+] activity	ADH7 ADH1B ADH1C	7.77e-06	30	26	3	GO:0018455
GeneOntologyMolecularFunction	thrombospondin receptor activity	CD47 F2	9.77e-06	4	26	2	GO:0070053
GeneOntologyMolecularFunction	NAD binding	ADH7 ADH1B ADH1C	1.15e-04	73	26	3	GO:0051287
GeneOntologyMolecularFunction	mitogen-activated protein kinase kinase binding	RAF1 BRAF	2.75e-04	19	26	2	GO:0031434
GeneOntologyMolecularFunction	alcohol binding	ADH7 ADH1B ADH1C	3.09e-04	102	26	3	GO:0043178
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	RAF1 BRAF	5.61e-04	27	26	2	GO:0004709
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ADH7 ADH1B ADH1C	5.87e-04	127	26	3	GO:0016616
GeneOntologyMolecularFunction	small GTPase binding	DOCK10 RAF1 ALS2 BRAF	7.41e-04	321	26	4	GO:0031267
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH-OH group of donors	ADH7 ADH1B ADH1C	7.47e-04	138	26	3	GO:0016614
GeneOntologyMolecularFunction	GTPase binding	DOCK10 RAF1 ALS2 BRAF	1.13e-03	360	26	4	GO:0051020
GeneOntologyMolecularFunction	growth factor activity	GPI F2 FGF18	1.44e-03	173	26	3	GO:0008083
GeneOntologyMolecularFunction	transition metal ion binding	ADH7 KDM2B TRIM26 ACO2 ADH1B ADH1C	3.62e-03	1189	26	6	GO:0046914
GeneOntologyMolecularFunction	molecular function activator activity	RAP1GAP2 GPI RAF1 ALS2 F2 FGF18	4.33e-03	1233	26	6	GO:0140677
GeneOntologyMolecularFunction	rRNA binding	KDM2B RPL3	4.72e-03	79	26	2	GO:0019843
GeneOntologyMolecularFunction	zinc ion binding	ADH7 KDM2B TRIM26 ADH1B ADH1C	5.26e-03	891	26	5	GO:0008270
GeneOntologyMolecularFunction	signaling receptor regulator activity	ADH7 GPI F2 FGF18	7.81e-03	616	26	4	GO:0030545
GeneOntologyBiologicalProcess	ethanol catabolic process	ADH7 ADH1B ADH1C	1.19e-06	17	26	3	GO:0006068
GeneOntologyBiologicalProcess	ethanol metabolic process	ADH7 ADH1B ADH1C	1.43e-06	18	26	3	GO:0006067
GeneOntologyBiologicalProcess	primary alcohol catabolic process	ADH7 ADH1B ADH1C	3.10e-06	23	26	3	GO:0034310
GeneOntologyBiologicalProcess	acetaldehyde biosynthetic process	ADH1B ADH1C	4.58e-06	3	26	2	GO:0046186
GeneOntologyBiologicalProcess	acetaldehyde metabolic process	ADH1B ADH1C	1.52e-05	5	26	2	GO:0006117
GeneOntologyBiologicalProcess	retinoic acid metabolic process	ADH7 ADH1B ADH1C	1.70e-05	40	26	3	GO:0042573
GeneOntologyBiologicalProcess	alcohol catabolic process	ADH7 ADH1B ADH1C	2.78e-05	47	26	3	GO:0046164
GeneOntologyBiologicalProcess	response to testosterone	GPI ADH1B ADH1C	3.99e-05	53	26	3	GO:0033574
GeneOntologyBiologicalProcess	retinol metabolic process	ADH7 ADH1B ADH1C	3.99e-05	53	26	3	GO:0042572
GeneOntologyBiologicalProcess	regulation of postsynaptic membrane neurotransmitter receptor levels	DNM3 SNAP23 ALS2 CNTNAP2	5.02e-05	164	26	4	GO:0099072
GeneOntologyBiologicalProcess	negative regulation of synaptic transmission, GABAergic	SLC6A1 CNTNAP2	5.47e-05	9	26	2	GO:0032229
GeneOntologyBiologicalProcess	behavior	SLC6A1 GPI ALS2 BRAF ADH1B ADH1C CNTNAP2	8.76e-05	891	26	7	GO:0007610
GeneOntologyBiologicalProcess	organic hydroxy compound catabolic process	ADH7 ADH1B ADH1C	1.04e-04	73	26	3	GO:1901616
GeneOntologyBiologicalProcess	alcohol metabolic process	ADH7 MYOF ACO2 ADH1B ADH1C	1.44e-04	412	26	5	GO:0006066
GeneOntologyBiologicalProcess	regulation of hormone levels	ADH7 SNAP23 RAF1 F2 ADH1B ADH1C	1.70e-04	684	26	6	GO:0010817
GeneOntologyBiologicalProcess	synapse organization	SLC6A1 CD47 DOCK10 DNM3 ALS2 CNTNAP2	1.71e-04	685	26	6	GO:0050808
GeneOntologyBiologicalProcess	retinoid metabolic process	ADH7 ADH1B ADH1C	1.88e-04	89	26	3	GO:0001523
GeneOntologyBiologicalProcess	behavioral response to ethanol	ADH1B ADH1C	2.05e-04	17	26	2	GO:0048149
GeneOntologyBiologicalProcess	diterpenoid metabolic process	ADH7 ADH1B ADH1C	2.21e-04	94	26	3	GO:0016101
GeneOntologyBiologicalProcess	neurotransmitter transport	SLC6A1 SNAP23 MYOF BRAF	2.92e-04	259	26	4	GO:0006836
GeneOntologyBiologicalProcess	terpenoid metabolic process	ADH7 ADH1B ADH1C	3.06e-04	105	26	3	GO:0006721
GeneOntologyBiologicalProcess	primary alcohol metabolic process	ADH7 ADH1B ADH1C	3.15e-04	106	26	3	GO:0034308
GeneOntologyBiologicalProcess	ATP transport	CD47 ABCC6	3.80e-04	23	26	2	GO:0015867
GeneOntologyBiologicalProcess	dendritic spine organization	DOCK10 DNM3 CNTNAP2	4.00e-04	115	26	3	GO:0097061
GeneOntologyBiologicalProcess	neuron projection organization	DOCK10 DNM3 CNTNAP2	5.34e-04	127	26	3	GO:0106027
GeneOntologyBiologicalProcess	response to muscle stretch	GPI RAF1	5.66e-04	28	26	2	GO:0035994
GeneOntologyBiologicalProcess	associative learning	SLC6A1 BRAF CNTNAP2	5.72e-04	130	26	3	GO:0008306
GeneOntologyBiologicalProcess	aldehyde biosynthetic process	ADH1B ADH1C	6.95e-04	31	26	2	GO:0046184
GeneOntologyBiologicalProcess	dendritic spine development	DOCK10 DNM3 CNTNAP2	7.25e-04	141	26	3	GO:0060996
GeneOntologyBiologicalProcess	isoprenoid metabolic process	ADH7 ADH1B ADH1C	7.70e-04	144	26	3	GO:0006720
GeneOntologyBiologicalProcess	thyroid gland development	RAF1 BRAF	8.36e-04	34	26	2	GO:0030878
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	SLC6A1 SNAP23 MYOF ALS2 BRAF CNTNAP2	8.81e-04	931	26	6	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	SLC6A1 SNAP23 MYOF ALS2 BRAF CNTNAP2	8.81e-04	931	26	6	GO:0007268
GeneOntologyBiologicalProcess	trans-synaptic signaling	SLC6A1 SNAP23 MYOF ALS2 BRAF CNTNAP2	9.21e-04	939	26	6	GO:0099537
GeneOntologyBiologicalProcess	response to ethanol	ADH7 ADH1B ADH1C	1.06e-03	161	26	3	GO:0045471
GeneOntologyBiologicalProcess	organic hydroxy compound metabolic process	ADH7 MYOF ACO2 ADH1B ADH1C	1.09e-03	641	26	5	GO:1901615
GeneOntologyBiologicalProcess	cell junction organization	SLC6A1 CD47 DOCK10 DNM3 ALS2 CNTNAP2	1.11e-03	974	26	6	GO:0034330
GeneOntologyBiologicalProcess	synaptic signaling	SLC6A1 SNAP23 MYOF ALS2 BRAF CNTNAP2	1.13e-03	976	26	6	GO:0099536
GeneOntologyBiologicalProcess	learning or memory	SLC6A1 GPI BRAF CNTNAP2	1.15e-03	373	26	4	GO:0007611
GeneOntologyBiologicalProcess	purine ribonucleotide transport	CD47 ABCC6	1.16e-03	40	26	2	GO:0015868
GeneOntologyBiologicalProcess	signal release	SNAP23 RAF1 MYOF BRAF F2	1.19e-03	653	26	5	GO:0023061
GeneOntologyBiologicalProcess	response to wounding	RAF1 MYOF BRAF F2 F9	1.23e-03	659	26	5	GO:0009611
GeneOntologyBiologicalProcess	adenine nucleotide transport	CD47 ABCC6	1.28e-03	42	26	2	GO:0051503
GeneOntologyBiologicalProcess	regulation of vascular endothelial growth factor receptor signaling pathway	MYOF FGF18	1.40e-03	44	26	2	GO:0030947
GeneOntologyBiologicalProcess	purine nucleotide transport	CD47 ABCC6	1.40e-03	44	26	2	GO:0015865
GeneOntologyBiologicalProcess	regulation of synaptic transmission, GABAergic	SLC6A1 CNTNAP2	1.46e-03	45	26	2	GO:0032228
GeneOntologyBiologicalProcess	olefinic compound metabolic process	ADH7 ADH1B ADH1C	1.47e-03	180	26	3	GO:0120254
GeneOntologyBiologicalProcess	response to hormone	GPI RAF1 BRAF ADH1B ADH1C CNTNAP2	1.58e-03	1042	26	6	GO:0009725
GeneOntologyBiologicalProcess	response to metal ion	SLC6A1 GPI BRAF ABCC6	1.70e-03	415	26	4	GO:0010038
GeneOntologyBiologicalProcess	small molecule catabolic process	ADH7 GPI ADH1B ADH1C	1.79e-03	421	26	4	GO:0044282
GeneOntologyBiologicalProcess	nucleotide transport	CD47 ABCC6	1.80e-03	50	26	2	GO:0006862
GeneOntologyBiologicalProcess	cognition	SLC6A1 GPI BRAF CNTNAP2	1.82e-03	423	26	4	GO:0050890
GeneOntologyBiologicalProcess	signal release from synapse	SNAP23 MYOF BRAF	1.84e-03	195	26	3	GO:0099643
GeneOntologyBiologicalProcess	neurotransmitter secretion	SNAP23 MYOF BRAF	1.84e-03	195	26	3	GO:0007269
GeneOntologyBiologicalProcess	positive regulation of protein phosphorylation	RAF1 ALS2 BRAF F2 FGF18	1.87e-03	724	26	5	GO:0001934
GeneOntologyBiologicalProcess	dendrite morphogenesis	DOCK10 DNM3 CNTNAP2	1.93e-03	198	26	3	GO:0048813
GeneOntologyBiologicalProcess	adult behavior	ADH1B ADH1C CNTNAP2	2.07e-03	203	26	3	GO:0030534
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	DOCK10 DNM3 ALS2 BRAF CNTNAP2	2.16e-03	748	26	5	GO:0048667
GeneOntologyCellularComponent	glutamatergic synapse	CD47 DOCK10 DNM3 SNAP23 ALS2 BRAF CNTNAP2	6.07e-05	817	27	7	GO:0098978
GeneOntologyCellularComponent	presynapse	SLC6A1 CD47 DNM3 SNAP23 MYOF BRAF CNTNAP2	1.01e-04	886	27	7	GO:0098793
GeneOntologyCellularComponent	neuron spine	DOCK10 DNM3 ALS2 CNTNAP2	2.70e-04	247	27	4	GO:0044309
HumanPheno	Premature skin wrinkling	SLC6A1 RAF1 BRAF ABCC6	1.90e-05	68	13	4	HP:0100678
HumanPheno	Hypophosphatemic rickets	RAF1 BRAF ABCC6	2.89e-05	25	13	3	HP:0004912
HumanPheno	Bruising susceptibility	RAF1 BRAF F2 F9 ABCC6	5.05e-05	178	13	5	HP:0000978
HumanPheno	Congenital giant melanocytic nevus	RAF1 BRAF	1.25e-04	7	13	2	HP:0005600
HumanPheno	Excessive wrinkled skin	RAF1 BRAF ABCC6	1.51e-04	43	13	3	HP:0007392
HumanPheno	Rickets	RAF1 BRAF ABCC6	1.97e-04	47	13	3	HP:0002748
MousePheno	abnormal ethanol metabolism	ADH7 ADH1B ADH1C	1.01e-07	6	25	3	MP:0005443
MousePheno	abnormal retinol metabolism	ADH7 ADH1B ADH1C	1.76e-07	7	25	3	MP:0005444
MousePheno	abnormal vitamin A metabolism	ADH7 ADH1B ADH1C	2.27e-06	15	25	3	MP:0011233
MousePheno	abnormal vitamin metabolism	ADH7 ADH1B ADH1C	2.27e-06	15	25	3	MP:0013244
MousePheno	abnormal vitamin or vitamin cofactor metabolism	ADH7 ADH1B ADH1C	2.27e-06	15	25	3	MP:0013274
MousePheno	enhanced behavioral response to alcohol	SLC6A1 ADH1B ADH1C	2.79e-06	16	25	3	MP:0009751
MousePheno	enhanced behavioral response to xenobiotic	SLC6A1 ADH7 ADH1B ADH1C	6.36e-06	69	25	4	MP:0009746
MousePheno	abnormal behavioral response to alcohol	SLC6A1 ADH1B ADH1C	9.98e-06	24	25	3	MP:0020157
MousePheno	increased susceptibility to induced morbidity/mortality	ADH7 RAF1 ALS2 F9 ADH1B ADH1C	2.62e-05	346	25	6	MP:0009763
MousePheno	enhanced behavioral response to addictive substance	SLC6A1 ADH1B ADH1C	6.38e-05	44	25	3	MP:0009749
MousePheno	abnormal susceptibility to induced morbidity/mortality	ADH7 RAF1 ALS2 F9 ADH1B ADH1C	1.45e-04	471	25	6	MP:0020148
MousePheno	abnormal induced morbidity/mortality	CD47 ADH7 RAF1 ALS2 F9 ADH1B ADH1C	2.29e-04	737	25	7	MP:0001657
Domain	ADH_Zn_CS	ADH7 ADH1B ADH1C	1.33e-07	8	26	3	IPR002328
Domain	ADH_ZINC	ADH7 ADH1B ADH1C	1.33e-07	8	26	3	PS00059
Domain	ADH_N	ADH7 ADH1B ADH1C	1.33e-06	16	26	3	PF08240
Domain	ADH_N	ADH7 ADH1B ADH1C	1.33e-06	16	26	3	IPR013154
Domain	-	ADH7 ADH1B ADH1C	1.93e-06	18	26	3	3.90.180.10
Domain	ADH_SF_Zn-type	ADH7 ADH1B ADH1C	2.29e-06	19	26	3	IPR002085
Domain	ADH_zinc_N	ADH7 ADH1B ADH1C	2.29e-06	19	26	3	PF00107
Domain	ADH_C	ADH7 ADH1B ADH1C	2.29e-06	19	26	3	IPR013149
Domain	GroES-like	ADH7 ADH1B ADH1C	4.75e-06	24	26	3	IPR011032
Domain	RBD	RAF1 BRAF	2.79e-05	6	26	2	PF02196
Domain	RBD	RAF1 BRAF	3.90e-05	7	26	2	SM00455
Domain	RBD_dom	RAF1 BRAF	3.90e-05	7	26	2	IPR003116
Domain	RBD	RAF1 BRAF	3.90e-05	7	26	2	PS50898
Domain	Coagulation_fac_subgr_Gla_dom	F2 F9	1.22e-04	12	26	2	IPR017857
Domain	-	F2 F9	1.22e-04	12	26	2	4.10.740.10
Domain	GLA	F2 F9	1.68e-04	14	26	2	SM00069
Domain	Gla	F2 F9	1.68e-04	14	26	2	PF00594
Domain	GLA_1	F2 F9	1.68e-04	14	26	2	PS00011
Domain	GLA_domain	F2 F9	1.68e-04	14	26	2	IPR000294
Domain	GLA_2	F2 F9	1.68e-04	14	26	2	PS50998
Domain	PKS_ER	ADH1B ADH1C	2.21e-04	16	26	2	IPR020843
Domain	PKS_ER	ADH1B ADH1C	2.21e-04	16	26	2	SM00829
Domain	DAG/PE-bd	RAF1 BRAF	3.85e-04	21	26	2	IPR020454
Domain	Laminin_G_2	COL5A3 CNTNAP2	1.41e-03	40	26	2	PF02210
Domain	-	ADH7 ADH1B ADH1C	1.62e-03	169	26	3	3.40.50.720
Domain	LamG	COL5A3 CNTNAP2	1.70e-03	44	26	2	SM00282
Domain	NAD(P)-bd_dom	ADH7 ADH1B ADH1C	1.74e-03	173	26	3	IPR016040
Domain	C1_1	RAF1 BRAF	2.84e-03	57	26	2	PF00130
Domain	Laminin_G	COL5A3 CNTNAP2	2.94e-03	58	26	2	IPR001791
Domain	ConA-like_dom	COL5A3 TRIM26 CNTNAP2	3.39e-03	219	26	3	IPR013320
Domain	ZF_DAG_PE_1	RAF1 BRAF	3.56e-03	64	26	2	PS00479
Domain	ZF_DAG_PE_2	RAF1 BRAF	3.56e-03	64	26	2	PS50081
Domain	C1	RAF1 BRAF	3.67e-03	65	26	2	SM00109
Domain	PE/DAG-bd	RAF1 BRAF	3.78e-03	66	26	2	IPR002219
Domain	PH	DOCK10 DNM3 ALS2	6.58e-03	278	26	3	SM00233
Domain	PH_DOMAIN	DOCK10 DNM3 ALS2	6.65e-03	279	26	3	PS50003
Domain	PH_domain	DOCK10 DNM3 ALS2	6.72e-03	280	26	3	IPR001849
Domain	TRYPSIN_SER	F2 F9	6.92e-03	90	26	2	IPR033116
Domain	-	COL5A3 CNTNAP2	7.68e-03	95	26	2	2.60.120.200
Pathway	WP_FATTY_ACID_OMEGAOXIDATION	ADH7 ADH1B ADH1C	5.86e-07	10	25	3	MM15833
Pathway	REACTOME_ETHANOL_OXIDATION	ADH7 ADH1B ADH1C	8.05e-07	11	25	3	MM15405
Pathway	REACTOME_ETHANOL_OXIDATION	ADH7 ADH1B ADH1C	1.07e-06	12	25	3	M14663
Pathway	WP_FATTY_ACID_OMEGAOXIDATION	ADH7 ADH1B ADH1C	2.21e-06	15	25	3	M39717
Pathway	KEGG_GLYCOLYSIS_GLUCONEOGENESIS	ADH7 GPI ADH1B ADH1C	4.00e-06	62	25	4	M11521
Pathway	WP_AMINO_ACID_METABOLISM	ADH7 ACO2 ADH1B ADH1C	2.48e-05	98	25	4	MM15942
Pathway	KEGG_MEDICUS_REFERENCE_FGF_FGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF FGF18	3.11e-05	35	25	3	M47379
Pathway	WP_PILOCYTIC_ASTROCYTOMA	RAF1 BRAF	4.51e-05	6	25	2	M39584
Pathway	REACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY	RAF1 BRAF	4.51e-05	6	25	2	M27559
Pathway	REACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY	RAF1 BRAF	4.51e-05	6	25	2	MM15273
Pathway	KEGG_TYROSINE_METABOLISM	ADH7 ADH1B ADH1C	5.40e-05	42	25	3	M16743
Pathway	KEGG_FATTY_ACID_METABOLISM	ADH7 ADH1B ADH1C	5.40e-05	42	25	3	M699
Pathway	REACTOME_DEFECTIVE_FACTOR_VIII_CAUSES_HEMOPHILIA_A	F2 F9	6.31e-05	7	25	2	M39000
Pathway	REACTOME_ABACAVIR_ADME	ADH1B ADH1C	8.40e-05	8	25	2	MM14869
Pathway	REACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS	RAF1 BRAF	8.40e-05	8	25	2	M38999
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE	RAF1 BRAF	8.40e-05	8	25	2	M47933
Pathway	REACTOME_TRANSPORT_OF_GAMMA_CARBOXYLATED_PROTEIN_PRECURSORS_FROM_THE_ENDOPLASMIC_RETICULUM_TO_THE_GOLGI_APPARATUS	F2 F9	1.08e-04	9	25	2	MM14614
Pathway	REACTOME_GAMMA_CARBOXYLATION_OF_PROTEIN_PRECURSORS	F2 F9	1.08e-04	9	25	2	MM14613
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	RAF1 BRAF F2 FGF18	1.31e-04	150	25	4	M39520
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY	RAF1 BRAF	1.35e-04	10	25	2	M47374
Pathway	KEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY	RAF1 BRAF	1.35e-04	10	25	2	M47420
Pathway	REACTOME_REMOVAL_OF_AMINOTERMINAL_PROPEPTIDES_FROM_GAMMA_CARBOXYLATED_PROTEINS	F2 F9	1.35e-04	10	25	2	M26977
Pathway	KEGG_MEDICUS_REFERENCE_RAC_CDC42_PAK_ERK_SIGNALING_PATHWAY	RAF1 BRAF	1.35e-04	10	25	2	M47735
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	RAF1 BRAF F2 FGF18	1.38e-04	152	25	4	MM15834
Pathway	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	F2 F9	1.64e-04	11	25	2	M12484
Pathway	KEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	1.64e-04	11	25	2	M47370
Pathway	KEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	1.64e-04	11	25	2	M47371
Pathway	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	F2 F9	1.64e-04	11	25	2	MM14615
Pathway	KEGG_RETINOL_METABOLISM	ADH7 ADH1B ADH1C	1.91e-04	64	25	3	M9488
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	1.97e-04	12	25	2	M47369
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY	RAF1 BRAF	1.97e-04	12	25	2	M47597
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	1.97e-04	12	25	2	M47815
Pathway	KEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY	RAF1 BRAF	2.33e-04	13	25	2	M47589
Pathway	WP_VITAMIN_K_METABOLISM_AND_ACTIVATION_OF_DEPENDENT_PROTEINS	F2 F9	2.33e-04	13	25	2	M45518
Pathway	PID_VEGFR1_2_PATHWAY	RAF1 MYOF BRAF	2.39e-04	69	25	3	M237
Pathway	KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	ADH7 ADH1B ADH1C	2.49e-04	70	25	3	M16794
Pathway	KEGG_MELANOMA	RAF1 BRAF FGF18	2.60e-04	71	25	3	M15798
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	ADH7 ADH1B ADH1C	2.71e-04	72	25	3	M9257
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	2.71e-04	14	25	2	M47364
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	2.71e-04	14	25	2	M47365
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	2.71e-04	14	25	2	M47366
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	2.71e-04	14	25	2	M47378
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY	RAF1 BRAF	2.71e-04	14	25	2	M47383
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY	RAF1 BRAF	2.71e-04	14	25	2	M47384
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	F2 F9	2.71e-04	14	25	2	MM1458
Pathway	PID_TCR_RAS_PATHWAY	RAF1 BRAF	2.71e-04	14	25	2	M134
Pathway	KEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	2.71e-04	14	25	2	M47488
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	F2 F9	2.71e-04	14	25	2	M6487
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47367
Pathway	REACTOME_RAP1_SIGNALLING	RAP1GAP2 RAF1	3.13e-04	15	25	2	MM15019
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47375
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47382
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47380
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47592
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47593
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47640
Pathway	KEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47485
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47473
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47474
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47480
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47495
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47496
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47497
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47472
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47535
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.13e-04	15	25	2	M47531
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.57e-04	16	25	2	M47363
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.57e-04	16	25	2	M47373
Pathway	KEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.57e-04	16	25	2	M47381
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.57e-04	16	25	2	M47804
Pathway	KEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.57e-04	16	25	2	M47801
Pathway	REACTOME_DEFECTS_OF_CONTACT_ACTIVATION_SYSTEM_CAS_AND_KALLIKREIN_KININ_SYSTEM_KKS	F2 F9	3.57e-04	16	25	2	M38996
Pathway	BIOCARTA_SPPA_PATHWAY	RAF1 F2	3.57e-04	16	25	2	M8731
Pathway	WP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER	RAF1 BRAF	3.57e-04	16	25	2	M39882
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	3.57e-04	16	25	2	M47483
Pathway	KEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY	RAF1 BRAF	3.57e-04	16	25	2	M47682
Pathway	REACTOME_RAP1_SIGNALLING	RAP1GAP2 RAF1	3.57e-04	16	25	2	M923
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	4.04e-04	17	25	2	M47376
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY	RAF1 BRAF	4.04e-04	17	25	2	M47684
Pathway	WP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS	RAF1 BRAF	4.54e-04	18	25	2	M39737
Pathway	KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	RAF1 BRAF F2 FGF18	5.00e-04	213	25	4	M18306
Pathway	REACTOME_DISEASES_OF_HEMOSTASIS	F2 F9	5.07e-04	19	25	2	M48230
Pathway	KEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY	RAF1 BRAF	5.07e-04	19	25	2	M47596
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	5.07e-04	19	25	2	M47793
Pathway	WP_AMINO_ACID_METABOLISM	ADH7 ACO2 ADH1C	5.40e-04	91	25	3	M39570
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF FGF18	5.58e-04	92	25	3	M47927
Pathway	KEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	6.21e-04	21	25	2	M47792
Pathway	WP_BLOOD_CLOTTING_CASCADE	F2 F9	6.82e-04	22	25	2	M39480
Pathway	BIOCARTA_INTRINSIC_PATHWAY	F2 F9	7.47e-04	23	25	2	M15997
Pathway	KEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY	RAF1 BRAF	7.47e-04	23	25	2	M47799
Pathway	WP_BLOOD_CLOTTING_CASCADE	F2 F9	7.47e-04	23	25	2	MM15936
Pathway	REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	F2 F9	7.47e-04	23	25	2	M14766
Pathway	BIOCARTA_INTRINSIC_PATHWAY	F2 F9	7.47e-04	23	25	2	MM1427
Pathway	REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	F2 F9	7.47e-04	23	25	2	MM14557
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	ADH7 ADH1B ADH1C	7.97e-04	104	25	3	M738
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	ADH7 ADH1B ADH1C	8.20e-04	105	25	3	MM14842
Pathway	WP_NOVEL_JUNDMP1_PATHWAY	RAF1 BRAF	8.83e-04	25	25	2	MM15984
Pathway	WP_FGFR3_SIGNALING_IN_CHONDROCYTE_PROLIFERATION_AND_TERMINAL_DIFFERENTIATION	RAF1 FGF18	1.03e-03	27	25	2	M39838
Pathway	WP_ESC_PLURIPOTENCY_PATHWAYS	RAF1 BRAF FGF18	1.09e-03	116	25	3	MM15863
Pathway	WP_MAPK_CASCADE	RAF1 BRAF	1.11e-03	28	25	2	MM15976
Pubmed	Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS.	ADH7 ADH1B ADH1C	3.71e-10	3	26	3	24722735
Pubmed	ADH1 and ADH4 alcohol/retinol dehydrogenases in the developing adrenal blastema provide evidence for embryonic retinoid endocrine function.	ADH7 ADH1B ADH1C	1.48e-09	4	26	3	9733106
Pubmed	Retinoic acid and alcohol/retinol dehydrogenase in the mouse adrenal gland: a potential endocrine source of retinoic acid during development.	ADH7 ADH1B ADH1C	1.48e-09	4	26	3	9202249
Pubmed	Genetic mapping of a possible new alcohol dehydrogenase sequence to mouse chromosome 3 at the Adh-1/Adh-3 complex.	ADH7 ADH1B ADH1C	1.48e-09	4	26	3	9241435
Pubmed	Molecular analysis of mouse alcohol dehydrogenase: nucleotide sequence of the Adh-1 gene and genetic mapping of a related nucleotide sequence to chromosome 3.	ADH7 ADH1B ADH1C	1.48e-09	4	26	3	2893758
Pubmed	Localization of class I and class IV alcohol dehydrogenases in mouse testis and epididymis: potential retinol dehydrogenases for endogenous retinoic acid synthesis.	ADH7 ADH1B ADH1C	1.48e-09	4	26	3	9002638
Pubmed	Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis.	ADH7 ADH1B ADH1C	3.70e-09	5	26	3	8892527
Pubmed	Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice.	ADH7 ADH1B ADH1C	3.70e-09	5	26	3	11836246
Pubmed	Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression.	ADH7 ADH1B ADH1C	3.70e-09	5	26	3	8621625
Pubmed	The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.	ADH7 ADH1B ADH1C	3.70e-09	5	26	3	20700531
Pubmed	Mouse alcohol dehydrogenase isozymes: products of closely localized duplicate genes exhibiting divergent kinetic properties.	ADH7 ADH1B ADH1C	3.70e-09	5	26	3	7026729
Pubmed	ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.	ADH7 ADH1B ADH1C	3.70e-09	5	26	3	19193628
Pubmed	Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population.	ADH7 ADH1B ADH1C	3.70e-09	5	26	3	19861527
Pubmed	Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease.	ADH7 ADH1B ADH1C	3.70e-09	5	26	3	22079585
Pubmed	Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid.	ADH7 ADH1B ADH1C	3.70e-09	5	26	3	10358022
Pubmed	Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family.	ADH7 ADH1B ADH1C	3.70e-09	5	26	3	7738026
Pubmed	High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease.	ADH7 ADH1B ADH1C	7.41e-09	6	26	3	17257171
Pubmed	Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3.	ADH7 ADH1B ADH1C	7.41e-09	6	26	3	12027900
Pubmed	Human liver alcohol dehydrogenase: purification, composition, and catalytic features.	ADH7 ADH1B ADH1C	7.41e-09	6	26	3	9982
Pubmed	Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3.	ADH7 ADH1B ADH1C	7.41e-09	6	26	3	518534
Pubmed	Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.	ADH7 ADH1B ADH1C	7.41e-09	6	26	3	17185388
Pubmed	Tissue- and species-specific expression patterns of class I, III, and IV Adh and Aldh 1 mRNAs in rodent embryos.	ADH7 ADH1B ADH1C	1.30e-08	7	26	3	16047160
Pubmed	Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes.	ADH7 ADH1B ADH1C	1.30e-08	7	26	3	11784316
Pubmed	Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.	ADH7 ADH1B ADH1C	1.30e-08	7	26	3	16685648
Pubmed	Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.	ADH7 ADH1B ADH1C	1.30e-08	7	26	3	23456092
Pubmed	Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.	ADH7 ADH1B ADH1C	1.30e-08	7	26	3	23468174
Pubmed	Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.	ADH7 ADH1B ADH1C	2.07e-08	8	26	3	18331377
Pubmed	A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.	ADH7 ADH1B ADH1C	2.07e-08	8	26	3	21437268
Pubmed	Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally.	ADH7 ADH1B ADH1C	3.11e-08	9	26	3	11747070
Pubmed	Expression of genes for alcohol and aldehyde metabolizing enzymes in mouse oocytes and preimplantation embryos.	ADH7 ADH1B ADH1C	8.12e-08	12	26	3	12128098
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	ADH7 ADH1B ADH1C	1.68e-07	15	26	3	9726281
Pubmed	An analysis of expression patterns of genes encoding proteins with catalytic activities.	GPI ACO2 ADH1B ADH1C	1.82e-07	67	26	4	17626619
Pubmed	Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development.	ADH7 ADH1B ADH1C	2.06e-07	16	26	3	15765518
Pubmed	Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.	ADH1B ADH1C	5.37e-07	2	26	2	8201622
Pubmed	Three-dimensional structures of the three human class I alcohol dehydrogenases.	ADH1B ADH1C	5.37e-07	2	26	2	11274460
Pubmed	Targets of Raf in tumorigenesis.	RAF1 BRAF	5.37e-07	2	26	2	20047953
Pubmed	Alcohol drinking, ADH1B and ADH1C genotypes and the risk of postmenopausal breast cancer by hormone receptor status: the Netherlands Cohort Study on diet and cancer.	ADH1B ADH1C	5.37e-07	2	26	2	30052783
Pubmed	Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth.	RAF1 BRAF	5.37e-07	2	26	2	25096573
Pubmed	Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis.	ADH1B ADH1C	5.37e-07	2	26	2	26042511
Pubmed	Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.	RAF1 BRAF	5.37e-07	2	26	2	22826437
Pubmed	In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry.	F2 F9	5.37e-07	2	26	2	19404534
Pubmed	Alcohol-metabolizing enzyme gene polymorphisms in the Basque Country, Morocco, and Ecuador.	ADH1B ADH1C	5.37e-07	2	26	2	21303386
Pubmed	B-Raf and C-Raf are required for melanocyte stem cell self-maintenance.	RAF1 BRAF	5.37e-07	2	26	2	23022482
Pubmed	In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.	RAF1 BRAF	5.37e-07	2	26	2	17018604
Pubmed	Immunoglobulin E sensitization to cross-reactive carbohydrate determinants: epidemiological study of clinical relevance and role of alcohol consumption.	ADH1B ADH1C	5.37e-07	2	26	2	20357489
Pubmed	Subjective response to alcohol and ADH polymorphisms in a select sample of young adult male East Indians and Africans in Trinidad and Tobago.	ADH1B ADH1C	5.37e-07	2	26	2	25208201
Pubmed	Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer.	RAF1 BRAF	5.37e-07	2	26	2	22833462
Pubmed	[Genetic variations in alcohol dehydrogenase, drinking habits and alcoholism].	ADH1B ADH1C	5.37e-07	2	26	2	18761854
Pubmed	Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci.	ADH1B ADH1C	5.37e-07	2	26	2	16184481
Pubmed	Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation.	RAF1 BRAF	5.37e-07	2	26	2	18205709
Pubmed	ADH genotype does not modify the effects of alcohol on high-density lipoprotein.	ADH1B ADH1C	5.37e-07	2	26	2	12658118
Pubmed	ADH1C*2 allele is associated with alcohol dependence and elevated liver enzymes in Trinidad and Tobago.	ADH1B ADH1C	5.37e-07	2	26	2	17134660
Pubmed	Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-Asians.	ADH1B ADH1C	5.37e-07	2	26	2	16930209
Pubmed	Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students.	ADH1B ADH1C	5.37e-07	2	26	2	16117582
Pubmed	Effect of alcohol dehydrogenase-1B and -7 polymorphisms on blood ethanol and acetaldehyde concentrations in healthy subjects with a history of moderate alcohol consumption.	ADH7 ADH1B	5.37e-07	2	26	2	28731573
Pubmed	Alcohol-metabolizing genes and alcohol phenotypes in an Israeli household sample.	ADH1B ADH1C	5.37e-07	2	26	2	23895337
Pubmed	Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.	RAF1 BRAF	5.37e-07	2	26	2	15035987
Pubmed	Association of the ADH2*3 allele with greater alcohol expectancies in African-American young adults.	ADH1B ADH1C	5.37e-07	2	26	2	12713190
Pubmed	Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry.	ADH1B ADH1C	5.37e-07	2	26	2	17268812
Pubmed	Multiple ADH genes are associated with upper aerodigestive cancers.	ADH7 ADH1B	5.37e-07	2	26	2	18500343
Pubmed	Alcohol consumption and risk of atrial fibrillation: Observational and genetic estimates of association.	ADH1B ADH1C	5.37e-07	2	26	2	27071860
Pubmed	Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism.	ADH1B ADH1C	5.37e-07	2	26	2	16086315
Pubmed	Single nucleotide polymorphisms in alcohol dehydrogenase genes among some Indian populations.	ADH1B ADH1C	5.37e-07	2	26	2	17421009
Pubmed	[Alcohol dehydrogenases ADH1B and ADH7 gene polymorphism in Russian population from the Siberian region].	ADH7 ADH1B	5.37e-07	2	26	2	15456134
Pubmed	Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation.	ADH1B ADH1C	5.37e-07	2	26	2	16737450
Pubmed	The significance of circulating factor IXa in blood.	F2 F9	5.37e-07	2	26	2	15039440
Pubmed	Determination of the effects of alcohol dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey.	ADH1B ADH1C	5.37e-07	2	26	2	22325912
Pubmed	B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms.	RAF1 BRAF	5.37e-07	2	26	2	15710605
Pubmed	BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF.	RAF1 BRAF	5.37e-07	2	26	2	23517740
Pubmed	Alcohol intake, ADH1B and ADH1C genotypes, and the risk of colorectal cancer by sex and subsite in the Netherlands Cohort Study.	ADH1B ADH1C	5.37e-07	2	26	2	29390059
Pubmed	ADH1B and ADH1C genotype, alcohol consumption and biomarkers of liver function: findings from a Mendelian randomization study in 58,313 European origin Danes.	ADH1B ADH1C	5.37e-07	2	26	2	25503943
Pubmed	Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population.	ADH1B ADH1C	5.37e-07	2	26	2	24735490
Pubmed	Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes.	ADH1B ADH1C	5.37e-07	2	26	2	17923853
Pubmed	Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk.	ADH1B ADH1C	5.37e-07	2	26	2	29058369
Pubmed	Alcohol intake, myocardial infarction, biochemical risk factors, and alcohol dehydrogenase genotypes.	ADH1B ADH1C	5.37e-07	2	26	2	20031627
Pubmed	Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome.	ADH1B ADH1C	5.37e-07	2	26	2	20494945
Pubmed	Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification.	ADH1B ADH1C	5.37e-07	2	26	2	3397059
Pubmed	Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.	ADH1B ADH1C	5.37e-07	2	26	2	1896463
Pubmed	Epidermal RAF prevents allergic skin disease.	RAF1 BRAF	5.37e-07	2	26	2	27431613
Pubmed	Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.	RAF1 BRAF	5.37e-07	2	26	2	25473895
Pubmed	RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.	RAF1 BRAF	5.37e-07	2	26	2	23680146
Pubmed	ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf.	RAF1 BRAF	5.37e-07	2	26	2	16172610
Pubmed	Raf kinases in cancer-roles and therapeutic opportunities.	RAF1 BRAF	5.37e-07	2	26	2	21577205
Pubmed	Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma.	ADH1B ADH1C	5.37e-07	2	26	2	25874489
Pubmed	Combined effect of ADH1B RS1229984, RS2066702 and ADH1C RS1693482/ RS698 alleles on alcoholism and chronic liver diseases.	ADH1B ADH1C	5.37e-07	2	26	2	22048268
Pubmed	BRAF inactivation drives aneuploidy by deregulating CRAF.	RAF1 BRAF	5.37e-07	2	26	2	20978199
Pubmed	Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis.	RAF1 BRAF	5.37e-07	2	26	2	22733131
Pubmed	Alcohol consumption, genetic variants in alcohol deydrogenases, and risk of cardiovascular diseases: a prospective study and meta-analysis.	ADH1B ADH1C	5.37e-07	2	26	2	22363810
Pubmed	Active Ras induces heterodimerization of cRaf and BRaf.	RAF1 BRAF	5.37e-07	2	26	2	11325826
Pubmed	Alcohol intake, alcohol dehydrogenase genotypes, and liver damage and disease in the Danish general population.	ADH1B ADH1C	5.37e-07	2	26	2	19550411
Pubmed	RAF inhibitors that evade paradoxical MAPK pathway activation.	RAF1 BRAF	5.37e-07	2	26	2	26466569
Pubmed	Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.	RAF1 BRAF	5.37e-07	2	26	2	26646323
Pubmed	CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.	RAF1 BRAF	5.37e-07	2	26	2	18794803
Pubmed	A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.	ADH7 ADH1B	5.37e-07	2	26	2	20336794
Pubmed	Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.	RAF1 BRAF	5.37e-07	2	26	2	16364920
Pubmed	Human stomach class IV alcohol dehydrogenase: molecular genetic analysis.	ADH7 ADH1C	5.37e-07	2	26	2	7771649
Pubmed	Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer.	ADH1B ADH1C	5.37e-07	2	26	2	17295732
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	GPI RAF1 MYOF BRAF	5.74e-07	89	26	4	27034005
Pubmed	Biochemical diversity and evolution in the genus Mus.	GPI ADH1B ADH1C	1.49e-06	30	26	3	6375655
Pubmed	Cross-talk between EphA2 and BRaf/CRaf is a key determinant of response to Dasatinib.	RAF1 BRAF	1.61e-06	3	26	2	24486585
Interaction	ADH1B interactions	RAF1 ADH1B ADH1C	5.41e-07	13	26	3	int:ADH1B
Interaction	FDX2 interactions	DOCK10 GPI ACO2	1.82e-05	40	26	3	int:FDX2
Interaction	STX1B interactions	SLC6A1 SNAP23 CNTNAP2	4.28e-05	53	26	3	int:STX1B
Interaction	AKR1A1 interactions	GPI ABCC6 ACO2	6.21e-05	60	26	3	int:AKR1A1
Interaction	SUCLG1 interactions	DOCK10 RAF1 ABCC6 ACO2	6.47e-05	171	26	4	int:SUCLG1
Interaction	IGFBP3 interactions	GPI RAF1 F2	6.53e-05	61	26	3	int:IGFBP3
Interaction	CEBPD interactions	SNAP23 MYOF TRIM26	6.85e-05	62	26	3	int:CEBPD
Interaction	F2 interactions	RAF1 F2 F9	1.16e-04	74	26	3	int:F2
Interaction	GGCX interactions	RAF1 F2 F9	1.26e-04	76	26	3	int:GGCX
Interaction	BRAF interactions	GPI RAF1 MYOF BRAF	1.48e-04	212	26	4	int:BRAF
Interaction	NQO1 interactions	GPI RAF1 TRIM26	1.69e-04	84	26	3	int:NQO1
Interaction	GPI interactions	GPI RAF1 BRAF ACO2	1.77e-04	222	26	4	int:GPI
Interaction	ANXA5 interactions	GPI RAF1 BRAF TRIM26	1.93e-04	227	26	4	int:ANXA5
Interaction	ARCN1 interactions	SLC6A1 GPI RAF1 ACO2	1.96e-04	228	26	4	int:ARCN1
Interaction	ARF5 interactions	GPI RAF1 BRAF CNTNAP2	2.06e-04	231	26	4	int:ARF5
Interaction	CTNNB1 interactions	CD47 SNAP23 RAF1 RPL3 TRIM26 ACO2 CNTNAP2	2.20e-04	1009	26	7	int:CTNNB1
Interaction	MRAS interactions	RAF1 BRAF	2.42e-04	18	26	2	int:MRAS
Interaction	MACROH2A1 interactions	GPI RAF1 RPL3 TRIM26 CNTNAP2	2.63e-04	458	26	5	int:MACROH2A1
Interaction	ADH1C interactions	ADH1B ADH1C	2.70e-04	19	26	2	int:ADH1C
Cytoband	Ensembl 112 genes in cytogenetic band chr4q23	ADH7 ADH1B ADH1C	1.56e-06	37	28	3	chr4q23
Cytoband	4q23	ADH1B ADH1C	6.77e-05	20	28	2	4q23
Cytoband	Ensembl 112 genes in cytogenetic band chr3p25	SLC6A1 RAF1	4.04e-03	155	28	2	chr3p25
GeneFamily	Alcohol dehydrogenases	ADH7 ADH1B ADH1C	7.53e-08	8	21	3	397
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	RAF1 BRAF	1.28e-05	5	21	2	1157
GeneFamily	Gla domain containing	F2 F9	9.95e-05	13	21	2	1250
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	RAF1 BRAF	3.49e-04	24	21	2	654
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOCK10 DNM3	2.35e-02	206	21	2	682
Coexpression	HEBERT_MATRISOME_TNBC_BONE_METASTASIS_TUMOR_CELL_DERIVED	COL5A3 F9	1.02e-05	5	27	2	M47996
Coexpression	GSE29618_LAIV_VS_TIV_FLU_VACCINE_DAY7_MONOCYTE_DN	RAP1GAP2 GPI RAF1 ACO2	4.56e-05	195	27	4	M5016
Coexpression	GSE5589_WT_VS_IL6_KO_LPS_STIM_MACROPHAGE_45MIN_UP	RAF1 KDM2B BRAF ADH1C	4.93e-05	199	27	4	M6638
Coexpression	HEBERT_MATRISOME_TNBC_BONE_METASTASIS	COL5A3 F9	5.59e-05	11	27	2	M47997
Coexpression	DAZARD_UV_RESPONSE_CLUSTER_G5	GPI ACO2	6.70e-05	12	27	2	M15114
Coexpression	NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_DN	ABCC6 ADH1B ADH1C	9.10e-05	85	27	3	M1451
Coexpression	HSIAO_LIVER_SPECIFIC_GENES	F2 F9 ABCC6 ADH1B	1.17e-04	249	27	4	M13283
CoexpressionAtlas	liver	SLC6A1 F2 F9 ABCC6 ADH1B ADH1C	9.38e-06	419	26	6	liver
CoexpressionAtlas	DevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_top-relative-expression-ranked_1000	CD47 ADH7 RAP1GAP2 MYOF BRAF ADH1C CNTNAP2	2.93e-05	772	26	7	gudmap_developingLowerUrinaryTract_P1_bladder_1000_J
CoexpressionAtlas	dev gonad_e11.5_M_GonMes_Sma_k-means-cluster#1_top-relative-expression-ranked_1000	ZAR1 DOCK10 FGF18 ADH1C	3.69e-05	156	26	4	gudmap_dev gonad_e11.5_M_GonMes_Sma_k1_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_P1_ureter_emap-30363_top-relative-expression-ranked_500	CD47 ADH7 MYOF ADH1C CNTNAP2	9.75e-05	390	26	5	gudmap_developingLowerUrinaryTract_P1_ureter_500
CoexpressionAtlas	BM Top 100 - liver	F9 ADH1B ADH1C	1.21e-04	79	26	3	BM Top 100 - liver
ToppCell	343B-Epithelial_cells-Epithelial-H_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SLC6A1 ADH7 FGF18 ADH1C	3.02e-06	161	28	4	da9eecf919866a9c579d7a707a996cf335213134
ToppCell	343B-Epithelial_cells-Epithelial-H_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SLC6A1 ADH7 FGF18 ADH1C	3.02e-06	161	28	4	d431625c32f59a6b552191f3adc5198bd16ad5cf
ToppCell	Control-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	SLC6A1 ADH7 FGF18 ADH1B	5.24e-06	185	28	4	d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC6A1 COL5A3 MYOF FGF18	5.95e-06	191	28	4	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP2 DNM3 DNAI4 MYOF	6.20e-06	193	28	4	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP2 DNM3 DNAI4 MYOF	6.20e-06	193	28	4	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP2 DNM3 DNAI4 MYOF	6.33e-06	194	28	4	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	PCW_10-12\|World / Celltypes from embryonic and fetal-stage human lung	DOCK10 MYOF ADH1B CNTNAP2	6.72e-06	197	28	4	47fd8b0d596c5db1a722473c8efbb17a6bbe7538
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-SERPINF1-L2-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZAR1 SLC6A1 DOCK10 CNTNAP2	7.14e-06	200	28	4	f922f9f223cbfed71b8e3115b16b51dc4d7b66b8
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Suprabasal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SLC6A1 ADH7 ADH1C CNTNAP2	7.14e-06	200	28	4	924eacea513dde8e3bd805a335bc4285647b800d
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-SERPINF1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZAR1 SLC6A1 DOCK10 CNTNAP2	7.14e-06	200	28	4	c4e08cf539c12bb7c61be6d44b4f074bb460f526
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Calb1_Sst\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC6A1 MYOF FGF18	1.03e-04	146	28	3	10839a4fce2e62955a90592f927a6e0c6a84bbad
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC6A1 DOCK10 CNTNAP2	1.08e-04	148	28	3	5e738522d4ad35e08bc4ff8c41b7bea38ec6ef95
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC6A1 DOCK10 CNTNAP2	1.16e-04	152	28	3	8ff5a178a8f3550d89a003c0858820aab3773386
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC6A1 DOCK10 CNTNAP2	1.16e-04	152	28	3	fed80b467ec9e30c7f98bed6cc4f8c583b715e9e
ToppCell	343B-Epithelial_cells-Epithelial-H_(AT1)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	SLC6A1 ADH7 ADH1C	1.28e-04	157	28	3	dd08dc19d434e94a194076c462ee273c682abf55
ToppCell	343B-Epithelial_cells-Epithelial-H_(AT1)\|343B / Donor, Lineage, Cell class and subclass (all cells)	SLC6A1 ADH7 ADH1C	1.28e-04	157	28	3	70fd6c46db4250c7de5c4686a9500689402737f6
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A3 SMIM28 F2	1.31e-04	158	28	3	7f5426585d0d299d2b48e5fcb349950feffdef33
ToppCell	390C-Epithelial_cells-Epithelial-H_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	ADH7 ADH1C CNTNAP2	1.35e-04	160	28	3	830f17bad94de05612fe6d53d39e42a4b3f3e2f3
ToppCell	390C-Epithelial_cells-Epithelial-H_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	ADH7 ADH1C CNTNAP2	1.35e-04	160	28	3	18ae6822915d16699beb9047baeef9b006901a35
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADH7 MYOF ADH1C	1.38e-04	161	28	3	9cfbbcd38ec2e75376bbc26001964b6991ad0e21
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC6A1 DOCK10 CNTNAP2	1.43e-04	163	28	3	8d17f44faf0549fe71a9a45f811f50d767275414
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZAR1 RAP1GAP2 ADH1C	1.56e-04	168	28	3	3e3f611e9bbec8224264666be14a4e7db343070e
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	RPL3 ADH1B ADH1C	1.59e-04	169	28	3	84b898a9fd8ced67c6a501d5cef6416f519902c4
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC6A1 DOCK10 COL5A3	1.62e-04	170	28	3	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADH7 MYOF ADH1C	1.68e-04	172	28	3	e9095c3dac66cf93d31f5f88364b565abacb1e2d
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC6A1 DOCK10 CNTNAP2	1.68e-04	172	28	3	7e1a7700a4c2b1d100da1d6e475e73498ebb605a
ToppCell	COVID-19-kidney-PCT-S3-2\|kidney / Disease (COVID-19 only), tissue and cell type	F2 F9 ADH1B	1.73e-04	174	28	3	5aa2fb631505600f37d2b87b02def7be139dc262
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL5A3 MYOF ADH1B	1.92e-04	180	28	3	f118c580134bdf3027e2218690cfc8a93468c1ae
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal-Mes\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL5A3 MYOF ADH1B	1.92e-04	180	28	3	1ade66352570a3f869e21e1055d0a65fbf56c61d
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADH7 MYOF ADH1C	1.92e-04	180	28	3	535a890bde0d978b461c2d4c571529b585c76b21
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_GGT8P\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 DOCK10 ABCC6	1.95e-04	181	28	3	9842537f9a607d8557c43790008d175edab1f32c
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal-Mes-Pericyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL5A3 MYOF ADH1B	1.95e-04	181	28	3	634a4f4e5942473e60d08d0b0936407b04bc6b7c
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal-Mes-Pericyte-Peri_L1-6_MUSTN1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL5A3 MYOF ADH1B	1.95e-04	181	28	3	c2938cf1f5d4875be07a56a1f36c94f8eab37d99
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC6A1 COL5A3 MYOF	2.04e-04	184	28	3	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZAR1 SLC6A1 DOCK10	2.08e-04	185	28	3	027020754dbf71b0034791f9a34ae795e3b85f81
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC6A1 COL5A3 MYOF	2.08e-04	185	28	3	a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZAR1 SLC6A1 DOCK10	2.14e-04	187	28	3	02105c82a9ba79d2f19e002188377fc3440770c2
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC6A1 COL5A3 MYOF	2.14e-04	187	28	3	a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A3 MYOF FGF18	2.21e-04	189	28	3	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SLC6A1 DOCK10 COL5A3	2.25e-04	190	28	3	10125091ad648163777b02e9f0d5e8d7f17d44a5
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL5A3 ADH1B ADH1C	2.25e-04	190	28	3	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SLC6A1 ABCC6 ADH1B	2.25e-04	190	28	3	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP2 DNM3 MYOF	2.25e-04	190	28	3	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP2 DNM3 MYOF	2.28e-04	191	28	3	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	10x5'v1-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FGF18 ADH1B ADH1C	2.28e-04	191	28	3	5271198116343c07202649889057e5774d7fdde3
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL5A3 ADH1B ADH1C	2.28e-04	191	28	3	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP2 DNM3 MYOF	2.28e-04	191	28	3	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 COL5A3 ADH1B	2.28e-04	191	28	3	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 COL5A3 ADH1B	2.28e-04	191	28	3	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 DOCK10 CNTNAP2	2.32e-04	192	28	3	67d6230e32d446dcb12047fae2c3f1faa80dd720
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 DOCK10 CNTNAP2	2.32e-04	192	28	3	bf1943715085c4124b1675888b0615c9500ec888
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 DOCK10 CNTNAP2	2.35e-04	193	28	3	9f9eb241b0b82a6f12de6921c3acf6fed7cf65bb
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADH7 MYOF ADH1C	2.35e-04	193	28	3	7c34abdcb8839b9fb25457a79af6c5e7b9714b21
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SLC6A1 COL5A3 CNTNAP2	2.35e-04	193	28	3	cf2461af78f65616ce40d552ee9452295e3895ed
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SLC6A1 COL5A3 CNTNAP2	2.35e-04	193	28	3	e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SLC6A1 COL5A3 CNTNAP2	2.35e-04	193	28	3	6ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 DOCK10 CNTNAP2	2.39e-04	194	28	3	4f758718a1233c25c25d99fc1b7b06f906b8b0a2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 DOCK10 CNTNAP2	2.39e-04	194	28	3	02a9cc821c2b14aa7d0e55661a5fab66364474e1
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK10 ADH1B CNTNAP2	2.39e-04	194	28	3	a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 COL5A3 ADH1B	2.42e-04	195	28	3	9ab3c5b0fb12d406408122a535b717bfe184bbcf
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 COL5A3 ADH1B	2.42e-04	195	28	3	21263d138c81f6a0219f2cd93126cfafd35732b2
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DOCK10 ADH1B CNTNAP2	2.42e-04	195	28	3	1cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 COL5A3 ADH1B	2.46e-04	196	28	3	5146976881d79642ebe5dcbcf89e0252713a9ef2
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 DOCK10 CNTNAP2	2.46e-04	196	28	3	7af6c5147ac859353504d19727dbe24f63a29dd4
ToppCell	critical-Epithelial-Secretory\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ADH7 MYOF ADH1B	2.46e-04	196	28	3	7da687eb983a54c28ee990424cc52e01caf5f4aa
ToppCell	critical-Epithelial-Secretory\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	GPI MYOF ADH1B	2.46e-04	196	28	3	dbf14f5851c2b779a8b35e820c4584ea9096e49d
ToppCell	NS-moderate-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ADH7 MYOF ADH1B	2.46e-04	196	28	3	47930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 COL5A3 ADH1B	2.46e-04	196	28	3	ebac1d6af7a5732707d82d01285c086b19d8ae62
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 COL5A3 ADH1B	2.50e-04	197	28	3	bc6c530330907a5ec823cc243c8e9c9e340cfb9c
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK10 ADH1B CNTNAP2	2.50e-04	197	28	3	31a1852911bda38543916585fda34255fd62a134
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADH7 MYOF ADH1C	2.50e-04	197	28	3	d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK10 ADH1B CNTNAP2	2.50e-04	197	28	3	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	PCW_13-14-Mesenchymal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK10 ADH1B CNTNAP2	2.50e-04	197	28	3	73a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DOCK10 ADH1B CNTNAP2	2.50e-04	197	28	3	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADH7 MYOF ADH1C	2.50e-04	197	28	3	80b05c8ad9c1edc5dea3236079372475431343fe
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 COL5A3 ADH1B	2.50e-04	197	28	3	77fe092aae8f05fe137680506892d2f61071d6ea
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADH7 MYOF ADH1C	2.54e-04	198	28	3	9718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell	moderate-Epithelial-Secretory\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ADH7 MYOF ADH1B	2.54e-04	198	28	3	7d96d7105a849c7280ce87bd76ce130ac47384fd
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLC6A1 ADH7 ADH1C	2.54e-04	198	28	3	de5987588b9fa9ee8c595ba06d7d844ead0e3c74
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADH7 RPL3 ADH1C	2.54e-04	198	28	3	7063d74d79f53d5c59c853a2575f9d3ef12f19ea
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADH7 MYOF RPL3	2.54e-04	198	28	3	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Pericyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SLC6A1 DOCK10 COL5A3	2.54e-04	198	28	3	72aad5b2dcd8b0bde58828fa4f8129fe6cb6a21d
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADH7 DNAI4 ADH1C	2.54e-04	198	28	3	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	Biopsy_Control_(H.)-Epithelial-Basal\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	ADH7 ADH1C CNTNAP2	2.57e-04	199	28	3	6a274a5db02c55bbf31d602b9d5c8394241acdca
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADH7 MYOF RPL3	2.57e-04	199	28	3	94a7867e800df352731796de8c24cba133c29622
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	COL5A3 ADH1B ADH1C	2.57e-04	199	28	3	95d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK10 RAP1GAP2 F9	2.57e-04	199	28	3	7d69785717073491b5fb81bf24db0175f86cd0b0
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADH7 RPL3 ADH1C	2.57e-04	199	28	3	974f71b56f66243c78f2f297a1540e0e186df530
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ADH7 ADH1C CNTNAP2	2.57e-04	199	28	3	995d710d7302272e7951a5a5d766d1039089ee2b
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ADH7 ADH1C CNTNAP2	2.57e-04	199	28	3	e9c47f565a0a7737ecff68569d668aeb707ae5a6
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD3\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK10 RAP1GAP2 F9	2.61e-04	200	28	3	6b34f2b85d4f83c1270ee151f602cba6f42042ba
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC6A1 GPI CNTNAP2	2.61e-04	200	28	3	858421b91f5207b7934b5c219752cb9322a3da31
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CCDC184-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC6A1 DOCK10 CNTNAP2	2.61e-04	200	28	3	140aff451cd58e1d544ee668e49e37e577f6f068
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC6A1 DNM3 CNTNAP2	2.61e-04	200	28	3	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC6A1 DOCK10 CNTNAP2	2.61e-04	200	28	3	48303e499251d6754cfa991dc2d96c5563b2123c
ToppCell	Neuronal-Inhibitory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC6A1 DOCK10 CNTNAP2	2.61e-04	200	28	3	9ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCell	background-Hepatocytes\|background / Sample and Cell Type and Tumor Cluster (all cells)	F2 F9 ADH1B	2.61e-04	200	28	3	787d35b5c2f2ad967ae14e99496a0299ac7e72fd
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD3-NKT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK10 RAP1GAP2 F9	2.61e-04	200	28	3	b2c5618aa1ac19423996336795dadb39ea57cda7
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1-L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC6A1 DOCK10 CNTNAP2	2.61e-04	200	28	3	2086024ce808b8796ed508a229b098eb02f8828a
Computational	Neighborhood of IGFBP1	F2 F9 ADH1B ADH1C	6.98e-06	57	24	4	CAR_IGFBP1
Computational	Oxidoreductases.	ADH7 ADH1B ADH1C	1.46e-05	22	24	3	MODULE_373
Computational	Genes in the cancer module 514.	ADH7 ADH1C	2.13e-04	10	24	2	MODULE_514
Computational	Neighborhood of IGF1	F2 ADH1C	1.50e-03	26	24	2	GNF2_IGF1
Computational	Neighborhood of TST	F2 ABCC6 ADH1C	1.54e-03	104	24	3	GNF2_TST
Computational	Neighborhood of GSTM1	F2 ABCC6 ADH1C	1.76e-03	109	24	3	GNF2_GSTM1
Drug	2-NA	ADH7 ADH1B ADH1C	1.11e-07	9	26	3	CID000074128
Drug	(3R,7R)-17-(6-hydroxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol	ADH7 ADH1B ADH1C	1.11e-07	9	26	3	CID000440672
Drug	AC1L1J0I	ADH7 ADH1B ADH1C	2.89e-07	12	26	3	CID000030201
Drug	hexa-2,4-dien-1-ol	ADH7 ADH1B ADH1C	2.89e-07	12	26	3	CID000008104
Drug	2-naphthaldehyde	ADH7 ADH1B ADH1C	3.75e-07	13	26	3	CID000006201
Drug	naphthalenemethanol	ADH7 ADH1B ADH1C	4.77e-07	14	26	3	CID000020908
Drug	1H-pyrazol	ADH7 F2 F9 ADH1B ADH1C	5.03e-07	141	26	5	CID000001048
Drug	6-[(3R,7R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptanal	ADH7 ADH1B ADH1C	5.96e-07	15	26	3	CID000440673
Drug	naphthaldehyde	ADH7 ADH1B ADH1C	7.33e-07	16	26	3	CID000006195
Drug	Ethylene Glycol	ADH7 ADH1B ADH1C	1.73e-06	21	26	3	ctd:D019855
Drug	1,5-AG	ADH7 RAF1 F2 ADH1B ADH1C	1.77e-06	182	26	5	CID000064960
Drug	tosylate	RAF1 BRAF F9	2.31e-06	23	26	3	CID000006101
Drug	AC1L1G9W	DNM3 F9 ADH1B ADH1C	3.34e-06	91	26	4	CID000003592
Drug	4-Iodopyrazole	ADH1B ADH1C	3.76e-06	3	26	2	DB02721
Drug	fomepizole	ADH7 ADH1B ADH1C	3.80e-06	27	26	3	ctd:C010238
Drug	dhmal	ADH7 ADH1B ADH1C	4.74e-06	29	26	3	CID000151725
Drug	AC1L1AOQ	ADH7 ADH1B ADH1C	5.26e-06	30	26	3	CID000001082
Drug	AC1L3MCS	F2 F9 ABCC6	5.26e-06	30	26	3	CID000091577
Drug	willardine	ADH7 ADH1B ADH1C	6.41e-06	32	26	3	CID000005123
Drug	walrycin A	ADH7 ADH1B ADH1C	6.41e-06	32	26	3	ctd:C574123
Drug	Fomepizole	ADH1B ADH1C	7.51e-06	4	26	2	DB01213
Drug	Gamma-Carboxy-Glutamic Acid	F2 F9	7.51e-06	4	26	2	DB03847
Drug	DOPEG	ADH7 ADH1B ADH1C	9.21e-06	36	26	3	CID000091528
Drug	2-Propanol	ADH7 ADH1B ADH1C	1.18e-05	39	26	3	ctd:D019840
Drug	3-hydroxyundecanoate	ADH1B ADH1C	1.25e-05	5	26	2	CID003083221
Drug	N-1-methylheptylformamide	ADH1B ADH1C	1.25e-05	5	26	2	CID005478865
Drug	AC1N9ZOZ	RAF1 BRAF	1.25e-05	5	26	2	CID004369133
Drug	3-hydroxynonanoate	ADH1B ADH1C	1.25e-05	5	26	2	CID000036599
Drug	Nicotinamide-Adenine-Dinucleotide	ADH7 ADH1B ADH1C	1.27e-05	40	26	3	DB01907
Drug	Retinaldehyde	ADH7 ADH1B ADH1C	1.47e-05	42	26	3	ctd:D012172
Drug	glyceraldehyde	ADH7 GPI ADH1B ADH1C	1.84e-05	140	26	4	CID000000751
Drug	Pentosan Sulfuric Polyester	F2 F9	1.88e-05	6	26	2	ctd:D010426
Drug	Buthionine Sulfoximine	GPI COL5A3 RPL3 ACO2 ADH1C	2.21e-05	306	26	5	ctd:D019328
Drug	Sorafenib	RAF1 BRAF	2.62e-05	7	26	2	DB00398
Drug	3-butylthiolane 1-oxide	ADH1B ADH1C	2.62e-05	7	26	2	CID003363251
Drug	Ethanol	ADH1B ADH1C	2.62e-05	7	26	2	DB00898
Drug	Nitric Oxide	GPI RAF1 COL5A3 F2 RPL3	3.46e-05	336	26	5	ctd:D009569
Drug	5-butyl-2-phenoxyphenol	ADH1B ADH1C	3.50e-05	8	26	2	CID005274975
Drug	3-keto-LCA	ADH1B ADH1C	3.50e-05	8	26	2	CID000159623
Drug	AC1NBLOP	ADH1B ADH1C	3.50e-05	8	26	2	CID004469995
Drug	N-heptylformamide	ADH1B ADH1C	3.50e-05	8	26	2	CID000347402
Drug	rhodizonic acid	CD47 GPI F2 ACO2	3.94e-05	170	26	4	CID000067050
Drug	4Amf	GPI F2	4.49e-05	9	26	2	CID000150955
Drug	12-oxododecanoic acid	ADH1B ADH1C	4.49e-05	9	26	2	CID000077563
Drug	Hydrocotarnine hydrobromide [5985-00-2]; Down 200; 13.2uM; HL60; HG-U133A	DOCK10 SNAP23 GPI ACO2	5.37e-05	184	26	4	1772_DN
Drug	Pradax	F2 F9	5.61e-05	10	26	2	CID006445226
Drug	Mometasone furoate [83919-23-7]; Up 200; 7.6uM; PC3; HT_HG-U133A	ADH7 RAP1GAP2 MYOF ADH1B	5.72e-05	187	26	4	5116_UP
Drug	octanol	ADH7 ADH1B ADH1C	5.77e-05	66	26	3	CID000000957
Drug	Cetirizine dihydrochloride [83881-52-1]; Down 200; 8.6uM; HL60; HT_HG-U133A	RAP1GAP2 DNM3 SNAP23 BRAF	6.73e-05	195	26	4	2468_DN
Drug	phenindione	F2 F9	6.85e-05	11	26	2	CID000004760
Drug	CI-1031	F2 F9	6.85e-05	11	26	2	CID005353802
Drug	Betazole hydrochloride; Up 200; 27uM; PC3; HT_HG-U133A	SNAP23 MYOF BRAF CNTNAP2	6.86e-05	196	26	4	6344_UP
Drug	phosphinate	GPI RPL3 FGF18	6.88e-05	70	26	3	CID000022497
Drug	AC1NUSZN	RAF1 BRAF F2	7.18e-05	71	26	3	CID005492221
Drug	Proglumide [6620-60-6]; Down 200; 12uM; PC3; HT_HG-U133A	CD47 SNAP23 MYOF CNTNAP2	7.28e-05	199	26	4	3780_DN
Drug	Pyrantel tartrate [33401-94-4]; Up 200; 11.2uM; MCF7; HT_HG-U133A	DNM3 SNAP23 MYOF BRAF	7.42e-05	200	26	4	5513_UP
Drug	5 beta-pregnane-3,20-dione	GPI ADH1B ADH1C	7.48e-05	72	26	3	CID000092745
Drug	2,2,2-trichloroethanol	ADH7 ADH1B ADH1C	7.80e-05	73	26	3	CID000008259
Drug	AC1L590V	ADH1B ADH1C	8.22e-05	12	26	2	CID000172417
Drug	Thr-Leu	RAF1 BRAF	8.22e-05	12	26	2	CID004420322
Drug	5-amidinoindole	F2 F9	8.22e-05	12	26	2	CID000122670
Drug	heptadecane	ADH1B ADH1C	8.22e-05	12	26	2	CID000012398
Drug	Cimetidine	ADH7 ADH1B ADH1C	8.79e-05	76	26	3	ctd:D002927
Drug	Menadione	F2 F9	9.71e-05	13	26	2	DB00170
Drug	3-methylbutanal	ADH1B ADH1C	9.71e-05	13	26	2	CID000011552
Drug	glutathionesulfonic acid	SLC6A1 RAF1 CNTNAP2	9.87e-05	79	26	3	CID000003486
Drug	C4 m	RAF1 F2 F9	9.87e-05	79	26	3	CID009543487
Drug	dabigatran	F2 F9	1.13e-04	14	26	2	CID000216210
Drug	benzyl alcohol	ADH7 ADH1B ADH1C	1.14e-04	83	26	3	CID000000244
Drug	4-methylpyrazole	ADH7 ADH1B ADH1C	1.18e-04	84	26	3	CID000003406
Drug	5 alpha-androstane	ADH7 ADH1B ADH1C	1.18e-04	84	26	3	CID000094144
Drug	Lindane	CD47 RAF1 F2 RPL3 ACO2	1.28e-04	443	26	5	ctd:D001556
Drug	Contraceptives, Oral	F2 F9	1.30e-04	15	26	2	ctd:D003276
Drug	AC1LAFI2	F2 F9	1.30e-04	15	26	2	CID000467477
Drug	3-hydroxyoctanoate	ADH1B ADH1C	1.30e-04	15	26	2	CID000026613
Drug	AC1L1G3W	ADH7 ACO2 ADH1B ADH1C	1.43e-04	237	26	4	CID000003514
Drug	phenoxyethanol	ADH1B ADH1C	1.49e-04	16	26	2	CID000031236
Drug	2BrP	RAF1 F2 F9	1.60e-04	93	26	3	CID006540269
Drug	dihydro-vitamin K1	F2 F9	1.69e-04	17	26	2	CID005189703
Drug	Tosylarginine Methyl Ester	F2 F9	1.69e-04	17	26	2	CID000013481
Drug	Dermatan Sulfate	F2 FGF18	1.69e-04	17	26	2	ctd:D003871
Drug	TCPOBOP	ABCC6 ADH1B ADH1C	1.71e-04	95	26	3	CID000005382
Drug	3H-DA	ADH1B ADH1C	1.90e-04	18	26	2	CID000026612
Drug	eicosapentaenoic acid ethyl ester	F2 F9	1.90e-04	18	26	2	ctd:C035276
Drug	omeprazole	ADH7 ADH1B ADH1C	2.05e-04	101	26	3	CID000004594
Drug	beta-NADP	ADH7 GPI ACO2 ADH1B ADH1C	2.05e-04	490	26	5	CID000000929
Drug	C x F	ADH1B ADH1C	2.12e-04	19	26	2	CID000013017
Drug	pentadecane	ADH1B ADH1C	2.12e-04	19	26	2	CID000012391
Drug	3-hydroxyvalerate	ADH1B ADH1C	2.12e-04	19	26	2	CID000107802
Drug	Peony	ADH1B ADH1C	2.35e-04	20	26	2	CID005483934
Drug	S 2160	F2 F9	2.35e-04	20	26	2	CID000189147
Drug	PM H	ADH1B ADH1C	2.35e-04	20	26	2	CID000445008
Drug	NCI60_002052	RAF1 BRAF	2.35e-04	20	26	2	CID006801032
Drug	3-hydroxydodecanoate	ADH1B ADH1C	2.60e-04	21	26	2	CID000094216
Drug	4-iodopyrazole	ADH1B ADH1C	2.60e-04	21	26	2	CID000077022
Drug	AC1L3UEY	RPL3 ADH1B ADH1C	2.85e-04	113	26	3	CID000122342
Drug	tantalum	F2 F9	2.86e-04	22	26	2	CID000023956
Drug	cc-309	F2 F9	2.86e-04	22	26	2	CID006433119
Drug	2,6-dichloro-4-nitrophenol	ADH7 ACO2	2.86e-04	22	26	2	ctd:C015802
Drug	NADP(H	ADH7 GPI ACO2 ADH1B ADH1C	2.87e-04	527	26	5	CID000000930
Disease	hemophilia B (is_implicated_in)	F2 F9	8.06e-07	2	27	2	DOID:12259 (is_implicated_in)
Disease	Malignant neoplasm of larynx	ADH7 ADH1B	8.06e-07	2	27	2	C0007107
Disease	Malignant neoplasm of pharynx	ADH7 ADH1B	8.06e-07	2	27	2	C0153405
Disease	Laryngeal neoplasm	ADH7 ADH1B	8.06e-07	2	27	2	C0023055
Disease	Pharyngeal Neoplasms	ADH7 ADH1B	8.06e-07	2	27	2	C0031347
Disease	alcohol use disorder measurement, alcohol dependence	ADH7 ADH1B ADH1C	1.37e-06	24	27	3	EFO_0009458, MONDO_0007079
Disease	parental emotion expression measurmement, conduct disorder	SLC6A1 ADH1B ADH1C	1.55e-06	25	27	3	EFO_0004216, EFO_0008342
Disease	Noonan syndrome with multiple lentigines	RAF1 BRAF	2.42e-06	3	27	2	cv:C0175704
Disease	Alcoholic Intoxication, Chronic	SLC6A1 ADH7 ADH1B ADH1C CNTNAP2	4.08e-06	268	27	5	C0001973
Disease	bitter alcoholic beverage consumption measurement	ADH7 ADH1B ADH1C CNTNAP2	6.39e-06	133	27	4	EFO_0010092
Disease	Kidney Neoplasm	DNM3 RAF1 BRAF	6.60e-06	40	27	3	C0022665
Disease	Alcohol dependence	ADH1B ADH1C	8.05e-06	5	27	2	cv:C0001973
Disease	ALCOHOL DEPENDENCE	ADH1B ADH1C	8.05e-06	5	27	2	103780
Disease	high grade glioma (implicated_via_orthology)	RAF1 BRAF F2	8.82e-06	44	27	3	DOID:3070 (implicated_via_orthology)
Disease	Malignant neoplasm of kidney	DNM3 RAF1 BRAF	9.45e-06	45	27	3	C0740457
Disease	Leopard Syndrome 1	RAF1 BRAF	1.21e-05	6	27	2	C4551484
Disease	Mouth Neoplasms	ADH7 ADH1B ADH1C	1.64e-05	54	27	3	C0026640
Disease	Malignant neoplasm of mouth	ADH7 ADH1B ADH1C	1.64e-05	54	27	3	C0153381
Disease	Pilomyxoid astrocytoma	RAF1 BRAF	1.69e-05	7	27	2	C1519086
Disease	alcohol dependence measurement	ADH7 ADH1B ADH1C	1.74e-05	55	27	3	EFO_0007835
Disease	response to vitamin	SLC6A1 BRAF	2.25e-05	8	27	2	GO_0033273
Disease	Noonan syndrome	RAF1 BRAF	2.89e-05	9	27	2	cv:C0028326
Disease	Alcohol abuse	F2 ADH1B ADH1C	3.15e-05	67	27	3	C0085762
Disease	alcohol use disorder measurement	ADH7 DNM3 ADH1B ADH1C	4.14e-05	214	27	4	EFO_0009458
Disease	Turner Syndrome, Male	RAF1 BRAF	4.41e-05	11	27	2	C0041409
Disease	Posterior Choroidal Artery Infarction	F2 ADH1B	4.41e-05	11	27	2	C0887799
Disease	Female Pseudo-Turner Syndrome	RAF1 BRAF	4.41e-05	11	27	2	C1527404
Disease	Cerebral Infarction, Left Hemisphere	F2 ADH1B	4.41e-05	11	27	2	C0751010
Disease	Anterior Choroidal Artery Infarction	F2 ADH1B	4.41e-05	11	27	2	C0751012
Disease	Cerebral Infarction, Right Hemisphere	F2 ADH1B	4.41e-05	11	27	2	C0751011
Disease	Subcortical Infarction	F2 ADH1B	4.41e-05	11	27	2	C0751014
Disease	Noonan Syndrome 1	RAF1 BRAF	4.41e-05	11	27	2	C4551602
Disease	Cerebral Infarction	F2 ADH1B	4.41e-05	11	27	2	C0007785
Disease	upper aerodigestive tract neoplasm	ADH7 TRIM26 ADH1B ADH1C	7.12e-05	246	27	4	EFO_0004284
Disease	RASopathy	RAF1 BRAF	8.40e-05	15	27	2	cv:C5555857
Disease	alcohol use disorder (is_implicated_in)	ADH1B ADH1C	9.60e-05	16	27	2	DOID:1574 (is_implicated_in)
Disease	high altitude adaptation	ADH7 ADH1C	1.09e-04	17	27	2	EFO_0009105
Disease	Malignant mesothelioma	RAF1 F9 FGF18	1.34e-04	109	27	3	C0345967
Disease	Noonan-Like Syndrome With Loose Anagen Hair	RAF1 BRAF	1.37e-04	19	27	2	C3501846
Disease	Costello syndrome (disorder)	RAF1 BRAF	1.37e-04	19	27	2	C0587248
Disease	Noonan syndrome-like disorder with loose anagen hair	RAF1 BRAF	1.37e-04	19	27	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	RAF1 BRAF	1.37e-04	19	27	2	C1275081
Disease	prostate adenocarcinoma (is_implicated_in)	RAF1 BRAF	1.52e-04	20	27	2	DOID:2526 (is_implicated_in)
Disease	sex interaction measurement, cerebral amyloid angiopathy	ADH1B ADH1C	1.68e-04	21	27	2	EFO_0006790, EFO_0008343
Disease	LEOPARD Syndrome	RAF1 BRAF	1.84e-04	22	27	2	C0175704
Disease	Noonan Syndrome	RAF1 BRAF	2.20e-04	24	27	2	C0028326
Disease	esophageal carcinoma	ADH7 ADH1B	3.45e-04	30	27	2	EFO_0002916
Disease	intellectual disability (is_implicated_in)	GPI CNTNAP2	3.45e-04	30	27	2	DOID:1059 (is_implicated_in)
Disease	Alcoholic Intoxication	ADH1B ADH1C	3.93e-04	32	27	2	C0001969
Disease	acute lymphoblastic leukemia (is_marker_for)	GPI KDM2B	4.44e-04	34	27	2	DOID:9952 (is_marker_for)
Disease	alcohol use disorder measurement, longitudinal alcohol consumption measurement	ADH1B ADH1C	5.26e-04	37	27	2	EFO_0007645, EFO_0009458
Disease	parasitemia measurement	ADH7 ADH1C	5.26e-04	37	27	2	EFO_0005528
Disease	venous thromboembolism, factor VII measurement	ADH7 F2	5.55e-04	38	27	2	EFO_0004286, EFO_0004619
Disease	non-alcoholic fatty liver disease	RAF1 ADH1B CNTNAP2	6.05e-04	182	27	3	EFO_0003095
Disease	alcohol dependence	ADH7 ADH1B ADH1C	6.15e-04	183	27	3	MONDO_0007079
Disease	sleep apnea	KDM2B FGF18	6.16e-04	40	27	2	EFO_0003877
Disease	Cutaneous Melanoma	RAF1 BRAF	6.47e-04	41	27	2	C0151779
Disease	liver fat measurement	ADH1B CNTNAP2	7.11e-04	43	27	2	EFO_0010821
Disease	Alcohol Use Disorder	ADH1B ADH1C	7.45e-04	44	27	2	C0001956
Disease	Thrombus	F2 F9	8.14e-04	46	27	2	C0087086

Protein segments in the cluster

Peptide	Gene	Start	Entry
TAGAKYGVGFWKPGS	ACO2	156	Q99798
FTGRTWKGCVFGGLK	ADH7	321	P40394
GSFGTVYKGKWHGDV	BRAF	466	P15056
GEWGSGIKITGTYFK	ALS2	1251	Q96Q42
TGRTWKGAVYGGFKS	ADH1B	311	P00325
TGRTWKGAIFGGFKS	ADH1C	311	P00326
GSGSFGTVYKGKWHG	RAF1	356	P04049
KYSAKWIDGSAGGIS	EURL	141	Q9NYK6
KGGSKGYWFVLTAES	DNM3	541	Q9UQ16
LKFGSGYVSGWGRVF	F9	346	P00740
YSGWYVGFTKKGRPR	FGF18	146	O76093
VRSGDWKGYTGKTIT	GPI	136	P06744
GGTSVWYHVFRGGKI	KDM2B	246	Q8NHM5
GAGGTGVFKSGWLYK	DOCK10	176	Q96BY6
GGAWGYRDFRGGQKK	DNAI4	16	Q5VTH9
GYAKINKRGGAGGWS	CNTNAP2	61	Q9UHC6
FWGQFGIKTLKYRSG	CD47	156	Q08722
SKEKPGGWYSTFRRG	COL5A3	1601	P25940
KGKGNYWTFAGGCES	FOXL3	101	A0A1W2PRP0
MFGRKRSVSFGGFGW	RAP1GAP2	1	Q684P5
KGVGWTGKVVYFSAT	SLC6A1	231	P30531
RKKGVQSSGVLFGYW	ABCC6	126	O95255
GVTKGKGYKGVTSRW	RPL3	221	P39023
GKAYKTTWGDGGENS	SNAP23	96	O00161
GSSWKKFGHAGRGTY	SMIM28	6	A0A1B0GU29
GVLGSKGFTWGKVYW	TRIM26	356	Q12899
GYKGRVTGWGNLKET	F2	496	P00734
YPAATKGKGAAGGSW	ZAR1	26	Q86SH2
FGKWGTSGLVGRHKF	MYOF	871	Q9NZM1