Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoabnormal iris stroma morphology

TGFB2 LYST

3.58e-0510132MP:0005208
DomainUncharacterised_FAM171

FAM171A2 FAM171A1

3.27e-063202IPR018890
DomainUPF0560

FAM171A2 FAM171A1

3.27e-063202PF10577
DomainWD40_repeat_CS

LYST TLE1 SCAP

6.79e-04164203IPR019775
DomainWD40

LYST TLE1 SCAP

2.52e-03259203PF00400
DomainWD40

LYST TLE1 SCAP

2.78e-03268203SM00320
DomainWD40_repeat

LYST TLE1 SCAP

2.90e-03272203IPR001680
DomainWD_REPEATS_1

LYST TLE1 SCAP

3.08e-03278203PS00678
DomainWD_REPEATS_2

LYST TLE1 SCAP

3.11e-03279203PS50082
DomainWD_REPEATS_REGION

LYST TLE1 SCAP

3.11e-03279203PS50294
DomainWD40_repeat_dom

LYST TLE1 SCAP

3.71e-03297203IPR017986
Domain-

LYST TLE1 SCAP

5.11e-033332032.130.10.10
DomainWD40/YVTN_repeat-like_dom

LYST TLE1 SCAP

5.20e-03335203IPR015943
Pubmed

Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors.

TGFB2 BRCA2

9.70e-06821218563556
Pubmed

Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering.

LYST TLE1

5.90e-05192129070936
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

BRCA2 DBF4B ZMYM4 FGD5 SCAP

7.21e-0575421535906200
Pubmed

SCAP knockout in SM22α-Cre mice induces defective angiogenesis in the placental labyrinth.

TGFB2 SCAP

1.21e-042721233227706
Pubmed

SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse.

TGFB2 ODF1

1.93e-043421236543770
InteractionCELF3 interactions

BRCA2 TLE1

4.95e-0512182int:CELF3
InteractionBACE2 interactions

FAM171A2 FAM171A1 FAM20C

5.07e-0582183int:BACE2
Cytoband17q21.31

FAM171A2 DBF4B

5.86e-048220217q21.31
CytobandEnsembl 112 genes in cytogenetic band chr13q13

BRCA2 SOHLH2

5.86e-0482202chr13q13
CytobandEnsembl 112 genes in cytogenetic band chr7p22

FAM20C MMD2

1.55e-03134202chr7p22
CytobandEnsembl 112 genes in cytogenetic band chr17q21

FAM171A2 DBF4B

1.78e-02473202chr17q21
GeneFamilyWD repeat domain containing

LYST TLE1 SCAP

1.46e-03262163362
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAM171A1 FGD5 TTC21A

5.19e-05156213ff39712c7a2dc1b85c598d5105789aa291dea726
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

FAM171A2 BRCA2 SOHLH2

6.59e-05169213a949f547b53126a208819bade74a1ac9b2a36ea7
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

FAM171A2 BRCA2 SOHLH2

6.59e-05169213195d5cd60d646ac6d40a3321b2f739917e7aef14
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM171A1 TLE1 ZMYM4

6.59e-05169213f086b50791e1c93e253eb5e8d6c4bf617b1416c3
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHISAL2B FAM20C TTC21A

6.82e-05171213f15594fd4d709920733de9376a391dedc62b65de
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHISAL2B FAM20C TTC21A

6.82e-05171213fea6ef6bbfebea2dd0f0360c7db7a5e858f15958
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM171A1 ZMYM4 FGD5

7.56e-051772138ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCelldroplet-Liver-Npc-21m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM171A2 FAM171A1 FGD5

8.21e-05182213dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCelldroplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM171A2 FAM171A1 FGD5

8.21e-05182213010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FAM171A2 BRCA2 SOHLH2

8.48e-051842136b2449ac65a2322aa0479fba0d89828f243aabbe
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FAM171A2 BRCA2 SOHLH2

8.48e-05184213e90622b82fa7f16a1faaf7a4724c958f2d83341d
ToppCellCOVID-19-lung-Vein_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FAM171A1 LYST FGD5

9.32e-051902131caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCellLPS-antiTNF-Endothelial-Endothelial-Vein|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 TLE1 FGD5

9.62e-0519221381baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 TLE1 FGD5

9.76e-051932137261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCelldroplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM171A2 FAM171A1 FGD5

1.01e-04195213f55ab1018a6cde7d517b53e6ce44c3f7bde485c4
ToppCelldroplet-Liver-LIVER-NPC-1m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM171A2 FAM171A1 FGD5

1.01e-04195213ea1b00805391dca8be0883b635768b296369919a
ToppCelldroplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM171A2 FAM171A1 FGD5

1.01e-0419521385df110f753f58ab017018c54ee454edb4428e29
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_ACKR1+_endothelial_cells|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FAM171A1 LYST LYRM9

1.04e-04197213143607d195c8aa2b94d995af0b2ef38582565611
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAM171A1 LYST FGD5

1.04e-04197213b0036cf3f7e6edf8e43f16cd2f0f0e80471d2576
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

FAM171A1 LYST TLE1

1.08e-04200213e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TGFB2 FAM171A1 TLE1

1.08e-0420021377ae679c35d3b9e2b620f34129f3a8d47e922c65
ComputationalNeighborhood of PRKAG1

LYST ODF1

9.32e-0450102GCM_PRKAG1
ComputationalNeighborhood of SUPT4H1

LYST ODF1

1.25e-0358102GCM_SUPT4H1
ComputationalNeighborhood of PRKCG

LYST ODF1

1.48e-0363102GCM_PRKCG
Diseaseirritability measurement

FBXL17 LYRM9

1.55e-0382212EFO_0009594
Diseaseforced expiratory volume, response to bronchodilator

TGFB2 TLE1 SOHLH2

3.70e-03445213EFO_0004314, GO_0097366
Diseasecolorectal cancer (is_marker_for)

TGFB2 BRCA2

5.53e-03157212DOID:9256 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
YVLKGNPLLLRVRCY

C2orf48

36

Q96LS8
CLPARYKLVELLCYV

MMD2

176

Q8IY49
LCLLLYYCRRKCLKP

FAM171A1

321

Q5VUB5
YCLATCLKLPVAQRR

SLC10A3

401

P09131
VCRNCSRNKYPLKYL

FGD5

1271

Q6ZNL6
CDYKLYCLRPSLRSL

ODF1

76

Q14990
ILLCLLIYYCRRRCL

FAM171A2

331

A8MVW0
LIYYCRRRCLKPRQQ

FAM171A2

336

A8MVW0
YCRHYCLLPLAAKQR

INTU

541

Q9ULD6
CLSPERVLLQLKYRY

BRCA2

2646

P51587
CPCLRLGYLYLLLTQ

DBF4B

536

Q8NFT6
PLQQCCRIRKSTYLR

FAM20C

496

Q8IXL6
CPGLLRYTAYRCKQL

FBXL17

411

Q9UF56
RLQRCYLTIPNKYLL

LYST

2961

Q99698
RRPLQLYRYLLRCCQ

LYRM9

11

A8MSI8
LYRYLLRCCQQLPTK

LYRM9

16

A8MSI8
LLCLYRVLCPRNYGQ

SCAP

726

Q12770
CVLCYLFLYTKPQRL

SHISAL2B

86

A6NKW6
NCCLRPLYIDFKRDL

TGFB2

316

P61812
CLNRDNYIRSCKLLP

TLE1

526

Q04724
LELLRRCVQYNKSCY

TTC21A

1221

Q8NDW8
RIKYCCEQLRTLLPY

SOHLH2

216

Q9NX45
LRCPVRLYEFYLSKC

ZMYM4

1466

Q5VZL5