Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX1 GATA6 HSFX1 HAND1 POU3F2 POU3F3 POU4F2 CDX2 FOXL2 CREB5 ZNF652 SKOR2 FOXB2	9.71e-10	1244	26	13	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SOX1 GATA6 HSFX1 HAND1 POU3F2 POU3F3 POU4F2 CDX2 FOXL2 CREB5 ZNF652 SKOR2 FOXB2	1.26e-09	1271	26	13	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX1 GATA6 HSFX1 HAND1 POU3F2 POU3F3 POU4F2 CDX2 FOXL2 CREB5 ZNF652 SKOR2 FOXB2	4.56e-09	1412	26	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX1 GATA6 HSFX1 HAND1 POU3F2 POU3F3 POU4F2 CDX2 FOXL2 CREB5 ZNF652 SKOR2 FOXB2	6.78e-09	1459	26	13	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SOX1 HAND1 POU3F2 POU4F2 FOXL2 CREB5	6.76e-05	560	26	6	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SOX1 HAND1 POU3F2 POU4F2 FOXL2 CREB5	7.17e-05	566	26	6	GO:0001216
GeneOntologyMolecularFunction	HMG box domain binding	POU3F2 POU3F3	4.06e-04	23	26	2	GO:0071837
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1A CATSPER1	1.63e-03	46	26	2	GO:0005245
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	SOX1 GATA6 HAND1 POU3F2 POU3F3 POU4F2 CDX2 FOXL2 VGLL2 CREB5	3.66e-06	1390	26	10	GO:0045944
GeneOntologyBiologicalProcess	forebrain ventricular zone progenitor cell division	POU3F2 POU3F3	2.28e-05	6	26	2	GO:0021869
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	SOX1 GATA6 HAND1 POU3F3 POU4F2 CDX2 FOXL2 SKOR2	3.08e-05	1053	26	8	GO:0000122
GeneOntologyBiologicalProcess	regulation of anatomical structure morphogenesis	GATA6 CACNA1A HRG POU3F2 PLK2 POU4F2 CDX2 SKOR2	3.94e-05	1090	26	8	GO:0022603
GeneOntologyBiologicalProcess	neuromuscular process controlling balance	SHANK1 CACNA1A POU4F2	1.09e-04	74	26	3	GO:0050885
GeneOntologyBiologicalProcess	Rap protein signal transduction	PLK2 CBL	1.38e-04	14	26	2	GO:0032486
GeneOntologyBiologicalProcess	positive regulation of apoptotic process	GATA6 HRG POU4F2 FOXL2 PHLDA1 PRR7	2.21e-04	718	26	6	GO:0043065
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	SOX1 GATA6 HAND1 POU3F3 POU4F2 CDX2 FOXL2 SKOR2	2.27e-04	1399	26	8	GO:0045892
GeneOntologyBiologicalProcess	cerebellar Purkinje cell differentiation	CACNA1A SKOR2	2.31e-04	18	26	2	GO:0021702
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	SOX1 GATA6 HAND1 POU3F3 POU4F2 CDX2 FOXL2 SKOR2	2.44e-04	1413	26	8	GO:1902679
GeneOntologyBiologicalProcess	positive regulation of programmed cell death	GATA6 HRG POU4F2 FOXL2 PHLDA1 PRR7	2.58e-04	739	26	6	GO:0043068
GeneOntologyBiologicalProcess	cerebellar Purkinje cell layer formation	CACNA1A SKOR2	2.86e-04	20	26	2	GO:0021694
GeneOntologyBiologicalProcess	cerebellar Purkinje cell layer morphogenesis	CACNA1A SKOR2	4.50e-04	25	26	2	GO:0021692
GeneOntologyBiologicalProcess	cellular response to growth factor stimulus	GATA6 HRG CBL NLK SKOR2 RNF111	5.46e-04	850	26	6	GO:0071363
GeneOntologyBiologicalProcess	response to growth factor	GATA6 HRG CBL NLK SKOR2 RNF111	6.67e-04	883	26	6	GO:0070848
GeneOntologyBiologicalProcess	reflex	SHANK1 CACNA1A	6.95e-04	31	26	2	GO:0060004
GeneOntologyBiologicalProcess	positive regulation of cardiac muscle cell apoptotic process	GATA6 POU4F2	7.40e-04	32	26	2	GO:0010666
GeneOntologyBiologicalProcess	cell differentiation in hindbrain	CACNA1A SKOR2	7.40e-04	32	26	2	GO:0021533
GeneOntologyBiologicalProcess	dendrite development	SHANK1 CACNA1A PLK2 SKOR2	7.70e-04	335	26	4	GO:0016358
GeneOntologyBiologicalProcess	positive regulation of striated muscle cell apoptotic process	GATA6 POU4F2	7.88e-04	33	26	2	GO:0010663
GeneOntologyBiologicalProcess	cell fate commitment	SOX1 GATA6 HAND1 POU3F2	7.96e-04	338	26	4	GO:0045165
GeneOntologyBiologicalProcess	intestinal epithelial cell differentiation	GATA6 CDX2	8.36e-04	34	26	2	GO:0060575
GeneOntologyBiologicalProcess	cerebellar cortex formation	CACNA1A SKOR2	8.36e-04	34	26	2	GO:0021697
GeneOntologyBiologicalProcess	cell proliferation in forebrain	POU3F2 POU3F3	1.04e-03	38	26	2	GO:0021846
GeneOntologyBiologicalProcess	cerebellar Purkinje cell layer development	CACNA1A SKOR2	1.10e-03	39	26	2	GO:0021680
GeneOntologyBiologicalProcess	columnar/cuboidal epithelial cell differentiation	GATA6 POU3F2 CDX2	1.12e-03	164	26	3	GO:0002065
GeneOntologyBiologicalProcess	cerebral cortex radially oriented cell migration	POU3F2 POU3F3	1.28e-03	42	26	2	GO:0021799
GeneOntologyBiologicalProcess	neuron fate specification	SOX1 POU3F2	1.28e-03	42	26	2	GO:0048665
GeneOntologyCellularComponent	chromatin	SOX1 GATA6 HSFX1 HAND1 POU3F2 POU3F3 PLK2 POU4F2 CDX2 FOXL2 CREB5 FOXB2	5.76e-08	1480	26	12	GO:0000785
GeneOntologyCellularComponent	transcription regulator complex	GATA6 HAND1 POU3F2 POU4F2 CDX2 SKOR2	7.41e-05	596	26	6	GO:0005667
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1A CATSPER1	1.49e-03	46	26	2	GO:0005891
MousePheno	absent temporal bone squamous part	POU3F3 MN1	2.82e-05	5	24	2	MP:0004899
Domain	POU_3	POU3F2 POU3F3 POU4F2	1.17e-06	16	25	3	PS51179
Domain	POU_1	POU3F2 POU3F3 POU4F2	1.17e-06	16	25	3	PS00035
Domain	POU	POU3F2 POU3F3 POU4F2	1.17e-06	16	25	3	SM00352
Domain	POU_2	POU3F2 POU3F3 POU4F2	1.17e-06	16	25	3	PS00465
Domain	Pou	POU3F2 POU3F3 POU4F2	1.17e-06	16	25	3	PF00157
Domain	POU_dom	POU3F2 POU3F3 POU4F2	1.17e-06	16	25	3	IPR000327
Domain	POU	POU3F2 POU3F3 POU4F2	1.42e-06	17	25	3	IPR013847
Domain	-	POU3F2 POU3F3 POU4F2	6.07e-06	27	25	3	1.10.260.40
Domain	Lambda_DNA-bd_dom	POU3F2 POU3F3 POU4F2	7.57e-06	29	25	3	IPR010982
Domain	TF_POU_3	POU3F2 POU3F3	1.03e-05	4	25	2	IPR016362
Domain	Homeobox_CS	POU3F2 POU3F3 POU4F2 CDX2	1.02e-04	186	25	4	IPR017970
Domain	Homeobox	POU3F2 POU3F3 POU4F2 CDX2	2.47e-04	234	25	4	PF00046
Domain	HOMEOBOX_1	POU3F2 POU3F3 POU4F2 CDX2	2.55e-04	236	25	4	PS00027
Domain	HOX	POU3F2 POU3F3 POU4F2 CDX2	2.59e-04	237	25	4	SM00389
Domain	Homeobox_dom	POU3F2 POU3F3 POU4F2 CDX2	2.68e-04	239	25	4	IPR001356
Domain	HOMEOBOX_2	POU3F2 POU3F3 POU4F2 CDX2	2.68e-04	239	25	4	PS50071
Domain	-	POU3F2 POU3F3 POU4F2 CDX2	5.08e-04	283	25	4	1.10.10.60
Domain	Homeodomain-like	POU3F2 POU3F3 POU4F2 CDX2	9.23e-04	332	25	4	IPR009057
Domain	TF_fork_head_CS_2	FOXL2 FOXB2	1.72e-03	46	25	2	IPR030456
Domain	TF_fork_head_CS_1	FOXL2 FOXB2	1.79e-03	47	25	2	IPR018122
Domain	FORK_HEAD_3	FOXL2 FOXB2	1.95e-03	49	25	2	PS50039
Domain	FH	FOXL2 FOXB2	1.95e-03	49	25	2	SM00339
Domain	FORK_HEAD_1	FOXL2 FOXB2	1.95e-03	49	25	2	PS00657
Domain	FORK_HEAD_2	FOXL2 FOXB2	1.95e-03	49	25	2	PS00658
Domain	Forkhead	FOXL2 FOXB2	1.95e-03	49	25	2	PF00250
Domain	Fork_head_dom	FOXL2 FOXB2	1.95e-03	49	25	2	IPR001766
Domain	Channel_four-helix_dom	CACNA1A CATSPER1	2.62e-03	57	25	2	IPR027359
Domain	-	CACNA1A CATSPER1	2.62e-03	57	25	2	1.20.120.350
Domain	Ion_trans_dom	CACNA1A CATSPER1	1.01e-02	114	25	2	IPR005821
Domain	Ion_trans	CACNA1A CATSPER1	1.01e-02	114	25	2	PF00520
Domain	Znf_C3HC4_RING-type	CBL RNF111	2.20e-02	172	25	2	IPR018957
Pathway	REACTOME_POU5F1_OCT4_SOX2_NANOG_REPRESS_GENES_RELATED_TO_DIFFERENTIATION	GATA6 CDX2	8.55e-05	10	20	2	M27208
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SHANK1 POU3F3 PLK2 CDX2 CBL PHLDA1 RBM33 VGLL2 CREB5 ZNF652 NLK RNF111	1.71e-11	1203	26	12	29180619
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX1 GATA6 HAND1 POU3F2 POU3F3 POU4F2 CDX2 FOXL2 CREB5 SKOR2	5.09e-10	908	26	10	19274049
Pubmed	Expression of a large family of POU-domain regulatory genes in mammalian brain development.	POU3F2 POU3F3 POU4F2	7.41e-09	6	26	3	2739723
Pubmed	Chromosomal organization of mammalian POU domain factors.	POU3F2 POU3F3 POU4F2	3.11e-08	9	26	3	8276396
Pubmed	Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.	SOX1 HAND1 CDX2	2.50e-07	17	26	3	20573702
Pubmed	Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.	SOX1 GATA6 CDX2	3.57e-07	19	26	3	35988542
Pubmed	Embryo model completes gastrulation to neurulation and organogenesis.	SOX1 GATA6 CDX2	5.66e-07	22	26	3	36007540
Pubmed	Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs.	HAND1 POU3F3 FOXL2	7.43e-07	24	26	3	18697905
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	SOX1 POU3F2 POU3F3	9.53e-07	26	26	3	22992956
Pubmed	Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals.	POU3F2 POU3F3	1.61e-06	3	26	2	8703082
Pubmed	The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.	POU3F2 POU3F3	1.61e-06	3	26	2	16547000
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	GATA6 POU3F2 CDX2 FOXL2 CREB5 SKOR2	2.51e-06	544	26	6	28473536
Pubmed	Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2.	GATA6 CDX2	3.22e-06	4	26	2	25488664
Pubmed	Mutually repressive interaction between Brn1/2 and Rorb contributes to the establishment of neocortical layer 2/3 and layer 4.	POU3F2 POU3F3	3.22e-06	4	26	2	26951672
Pubmed	Structure and evolution of four POU domain genes expressed in mouse brain.	POU3F2 POU3F3	3.22e-06	4	26	2	1565620
Pubmed	Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.	POU3F2 POU3F3	3.22e-06	4	26	2	26265007
Pubmed	Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3.	GATA6 CBL	5.37e-06	5	26	2	32145025
Pubmed	The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.	POU3F2 POU3F3	5.37e-06	5	26	2	9105675
Pubmed	A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction.	HAND1 CDX2	5.37e-06	5	26	2	21302256
Pubmed	Cooperative function of POU proteins and SOX proteins in glial cells.	POU3F2 POU3F3	5.37e-06	5	26	2	9632656
Pubmed	Progression of the pluripotent epiblast depends upon the NMD factor UPF2.	GATA6 CDX2	8.05e-06	6	26	2	36255229
Pubmed	Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo.	POU3F2 POU3F3	8.05e-06	6	26	2	15465489
Pubmed	The primitive endoderm supports lineage plasticity to enable regulative development.	GATA6 CDX2	8.05e-06	6	26	2	38917790
Pubmed	Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells.	POU3F2 POU3F3	8.05e-06	6	26	2	15262984
Pubmed	Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.	GATA6 HAND1 CDX2	9.48e-06	55	26	3	10926756
Pubmed	Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells.	SOX1 POU3F2	1.13e-05	7	26	2	15456859
Pubmed	Early developmental plasticity enables the induction of an intermediate extraembryonic cell state.	GATA6 CDX2	1.13e-05	7	26	2	36332016
Pubmed	The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo.	GATA6 CDX2	1.13e-05	7	26	2	28289135
Pubmed	Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo.	GATA6 CDX2	1.13e-05	7	26	2	20479880
Pubmed	Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice.	POU3F2 POU3F3	1.13e-05	7	26	2	17301088
Pubmed	FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst.	GATA6 CDX2	1.13e-05	7	26	2	24063807
Pubmed	Two distinct sources for a population of maturing axial progenitors.	SOX1 CDX2	1.13e-05	7	26	2	17611225
Pubmed	Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF.	GATA6 CDX2	1.13e-05	7	26	2	36260992
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	GATA6 HAND1 POU4F2 CDX2	1.20e-05	191	26	4	24146773
Pubmed	Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis.	GATA6 CDX2	1.50e-05	8	26	2	26199412
Pubmed	BRN2 as a key gene drives the early primate telencephalon development.	SOX1 POU3F2	1.50e-05	8	26	2	35245119
Pubmed	Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network.	GATA6 CDX2	1.50e-05	8	26	2	25209243
Pubmed	The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development.	GATA6 HAND1	1.50e-05	8	26	2	31422919
Pubmed	Atad3 function is essential for early post-implantation development in the mouse.	HAND1 CDX2	1.50e-05	8	26	2	23372768
Pubmed	POU-III transcription factors (Brn1, Brn2, and Oct6) influence neurogenesis, molecular identity, and migratory destination of upper-layer cells of the cerebral cortex.	POU3F2 POU3F3	1.50e-05	8	26	2	22892427
Pubmed	Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development.	POU3F2 POU3F3	1.50e-05	8	26	2	19147497
Pubmed	Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells.	POU3F2 POU4F2	1.93e-05	9	26	2	24643061
Pubmed	Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst.	GATA6 CDX2	1.93e-05	9	26	2	18725515
Pubmed	Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.	POU3F2 POU3F3	1.93e-05	9	26	2	15872005
Pubmed	Specification of embryonic stem cell-derived tissues into eye fields by Wnt signaling using rostral diencephalic tissue-inducing culture.	SOX1 POU4F2	1.93e-05	9	26	2	27151576
Pubmed	H3K27me3 at pericentromeric heterochromatin is a defining feature of the early mouse blastocyst.	GATA6 CDX2	1.93e-05	9	26	2	35974030
Pubmed	Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin.	GATA6 CDX2	2.41e-05	10	26	2	20826529
Pubmed	Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2.	GATA6 CDX2	2.41e-05	10	26	2	28552559
Pubmed	Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.	GATA6 CDX2	2.41e-05	10	26	2	16678776
Pubmed	Hectd1 is required for development of the junctional zone of the placenta.	HAND1 CDX2	2.41e-05	10	26	2	24855001
Pubmed	CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State.	GATA6 CDX2	2.41e-05	10	26	2	27746116
Pubmed	Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development.	HAND1 CDX2	2.94e-05	11	26	2	12015300
Pubmed	Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development.	HAND1 CDX2	2.94e-05	11	26	2	18794365
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	GATA6 CDX2	2.94e-05	11	26	2	37012455
Pubmed	Xist/Tsix expression dynamics during mouse peri-implantation development revealed by whole-mount 3D RNA-FISH.	GATA6 CDX2	2.94e-05	11	26	2	30842444
Pubmed	GATA4 Controls Epithelial Morphogenesis in the Developing Stomach to Promote Establishment of Glandular Columnar Epithelium.	GATA6 CDX2	2.94e-05	11	26	2	34111600
Pubmed	CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart.	GATA6 HAND1	2.94e-05	11	26	2	35450884
Pubmed	Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development†.	GATA6 CDX2	2.94e-05	11	26	2	39194072
Pubmed	Murine chromosomal location of four class III POU transcription factors.	POU3F2 POU3F3	3.53e-05	12	26	2	8276397
Pubmed	Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.	GATA6 CDX2	3.53e-05	12	26	2	27292645
Pubmed	Morphogenetic analysis of peri-implantation development.	GATA6 CDX2	3.53e-05	12	26	2	23728800
Pubmed	Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation.	HAND1 CDX2	3.53e-05	12	26	2	20837524
Pubmed	RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription.	GATA6 CDX2	3.53e-05	12	26	2	35981753
Pubmed	Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4.	GATA6 CDX2	3.53e-05	12	26	2	28870993
Pubmed	Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst.	HAND1 CDX2	3.53e-05	12	26	2	15788452
Pubmed	SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages.	HAND1 CDX2	3.53e-05	12	26	2	19090619
Pubmed	Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium.	POU3F2 POU3F3	3.53e-05	12	26	2	19743445
Pubmed	Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.	POU3F2 POU3F3	4.17e-05	13	26	2	8543156
Pubmed	Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation.	GATA6 CDX2	4.17e-05	13	26	2	23824537
Pubmed	Characterization of Olig2 expression during cerebellar development.	POU3F2 SKOR2	4.17e-05	13	26	2	24594479
Pubmed	BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos.	GATA6 CDX2	4.17e-05	13	26	2	35264162
Pubmed	The Hippo pathway member Nf2 is required for inner cell mass specification.	GATA6 CDX2	4.17e-05	13	26	2	23791728
Pubmed	Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface.	HAND1 CDX2	4.17e-05	13	26	2	32513715
Pubmed	Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential before implantation.	GATA6 CDX2	4.17e-05	13	26	2	38752427
Pubmed	CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development.	GATA6 CDX2	4.17e-05	13	26	2	24036311
Pubmed	Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors.	POU3F2 POU3F3	4.17e-05	13	26	2	19403657
Pubmed	Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst.	GATA6 CDX2	4.17e-05	13	26	2	23747191
Pubmed	Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse.	GATA6 CDX2	4.17e-05	13	26	2	35796552
Pubmed	Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.	POU3F2 POU3F3	4.86e-05	14	26	2	17141158
Pubmed	Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development.	HAND1 CDX2	4.86e-05	14	26	2	28067313
Pubmed	Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency.	GATA6 CDX2	4.86e-05	14	26	2	28552557
Pubmed	Trophectoderm mechanics direct epiblast shape upon embryo implantation.	GATA6 CDX2	4.86e-05	14	26	2	33472064
Pubmed	Regulation of the ERK signalling pathway in the developing mouse blastocyst.	GATA6 CDX2	4.86e-05	14	26	2	31320324
Pubmed	A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo.	GATA6 CDX2	4.86e-05	14	26	2	23788624
Pubmed	Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice.	GATA6 HAND1	5.61e-05	15	26	2	18448675
Pubmed	Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.	POU3F2 POU3F3	5.61e-05	15	26	2	18255031
Pubmed	Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart.	GATA6 HAND1	5.61e-05	15	26	2	19004760
Pubmed	GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst.	GATA6 CDX2	5.61e-05	15	26	2	24835466
Pubmed	GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.	GATA6 CDX2	6.41e-05	16	26	2	26932670
Pubmed	The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.	POU3F2 POU3F3	6.41e-05	16	26	2	9118797
Pubmed	Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes.	SOX1 CDX2	6.41e-05	16	26	2	30661984
Pubmed	Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.	POU3F2 POU3F3	6.41e-05	16	26	2	19527706
Pubmed	A balanced Oct4 interactome is crucial for maintaining pluripotency.	GATA6 CDX2	6.41e-05	16	26	2	35171666
Pubmed	Compartmentalized metabolism supports midgestation mammalian development.	HAND1 CDX2	7.26e-05	17	26	2	35388219
Pubmed	Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass.	GATA6 CDX2	7.26e-05	17	26	2	21471155
Pubmed	TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.	SOX1 CDX2	7.26e-05	17	26	2	35950911
Pubmed	Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation.	POU3F3 POU4F2	8.16e-05	18	26	2	25989023
Pubmed	Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.	GATA6 CDX2	8.16e-05	18	26	2	25569111
Pubmed	Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells.	HAND1 CDX2	8.16e-05	18	26	2	31260508
Pubmed	Foxh1 is essential for development of the anterior heart field.	GATA6 HAND1	8.16e-05	18	26	2	15363409
Interaction	RNF4 interactions	SHANK1 POU3F3 PLK2 CDX2 CBL PHLDA1 RBM33 VGLL2 CREB5 ZNF652 NLK RNF111	2.95e-08	1412	25	12	int:RNF4
Interaction	KRTAP5-9 interactions	POU4F2 CATSPER1 PHLDA1 CREB5 NLK RNF111	1.46e-07	203	25	6	int:KRTAP5-9
Interaction	KRTAP4-2 interactions	POU4F2 CATSPER1 PHLDA1 CREB5 NLK	5.34e-07	132	25	5	int:KRTAP4-2
Interaction	LGALS13 interactions	POU4F2 PHLDA1 CREB5	1.13e-06	17	25	3	int:LGALS13
Interaction	KRTAP4-12 interactions	POU4F2 CDX2 CATSPER1 PHLDA1 CREB5	1.43e-06	161	25	5	int:KRTAP4-12
Interaction	KRTAP5-6 interactions	POU4F2 CATSPER1 CREB5 NLK	5.21e-06	94	25	4	int:KRTAP5-6
Interaction	KRTAP1-1 interactions	POU4F2 CATSPER1 PHLDA1 CREB5 RNF111	6.44e-06	219	25	5	int:KRTAP1-1
Interaction	KRTAP9-8 interactions	POU4F2 CATSPER1 PHLDA1 CREB5	6.66e-06	100	25	4	int:KRTAP9-8
Interaction	SPRY1 interactions	CACNA1A HRG CBL CREB5	1.01e-05	111	25	4	int:SPRY1
Interaction	CDPF1 interactions	CATSPER1 PHLDA1 CREB5	1.27e-05	37	25	3	int:CDPF1
Interaction	KRTAP12-2 interactions	HSFX1 POU4F2 CATSPER1 PHLDA1	1.77e-05	128	25	4	int:KRTAP12-2
Interaction	POU3F4 interactions	POU3F2 POU3F3	2.21e-05	6	25	2	int:POU3F4
Interaction	KRTAP9-3 interactions	POU4F2 CATSPER1 PHLDA1 CREB5	2.52e-05	140	25	4	int:KRTAP9-3
Interaction	KRTAP12-3 interactions	POU4F2 CATSPER1 PHLDA1 CREB5	2.97e-05	146	25	4	int:KRTAP12-3
Interaction	CYSRT1 interactions	CACNA1A HRG POU4F2 CATSPER1 PHLDA1 CREB5	3.03e-05	511	25	6	int:CYSRT1
Interaction	TRIM42 interactions	POU4F2 CATSPER1 PHLDA1 CREB5	3.22e-05	149	25	4	int:TRIM42
Interaction	KRTAP9-2 interactions	POU4F2 CATSPER1 PHLDA1 CREB5	3.22e-05	149	25	4	int:KRTAP9-2
Interaction	KRTAP10-1 interactions	POU4F2 CATSPER1 CREB5 NLK	3.57e-05	153	25	4	int:KRTAP10-1
Interaction	TSPAN4 interactions	CATSPER1 PHLDA1 CREB5	3.79e-05	53	25	3	int:TSPAN4
Interaction	SOX11 interactions	POU3F2 POU3F3	4.12e-05	8	25	2	int:SOX11
Interaction	KRTAP5-4 interactions	POU4F2 CATSPER1 CREB5	6.38e-05	63	25	3	int:KRTAP5-4
Interaction	KRTAP10-11 interactions	POU4F2 CATSPER1 CREB5	6.68e-05	64	25	3	int:KRTAP10-11
Interaction	KRTAP5-11 interactions	POU4F2 CATSPER1 CREB5	7.33e-05	66	25	3	int:KRTAP5-11
Interaction	KRTAP5-3 interactions	POU4F2 CATSPER1 CREB5	7.33e-05	66	25	3	int:KRTAP5-3
Interaction	KRTAP3-2 interactions	POU4F2 CATSPER1 CREB5	1.25e-04	79	25	3	int:KRTAP3-2
Interaction	KRTAP19-6 interactions	POU4F2 CATSPER1 CREB5	1.25e-04	79	25	3	int:KRTAP19-6
Interaction	KRTAP4-4 interactions	POU4F2 CATSPER1 CREB5	1.35e-04	81	25	3	int:KRTAP4-4
Interaction	SPRY4 interactions	POU4F2 CBL CREB5	1.61e-04	86	25	3	int:SPRY4
Interaction	LCE2C interactions	POU4F2 CATSPER1 CREB5	1.73e-04	88	25	3	int:LCE2C
Interaction	NBPF19 interactions	CATSPER1 PHLDA1 CREB5 RNF111	1.82e-04	233	25	4	int:NBPF19
Interaction	LCE5A interactions	POU4F2 CATSPER1 CREB5	1.84e-04	90	25	3	int:LCE5A
Interaction	KRTAP4-11 interactions	POU4F2 CATSPER1 CREB5	1.97e-04	92	25	3	int:KRTAP4-11
Interaction	LCE1F interactions	POU4F2 CATSPER1 CREB5	1.97e-04	92	25	3	int:LCE1F
Interaction	CHRD interactions	HRG POU4F2 CATSPER1	2.10e-04	94	25	3	int:CHRD
Interaction	KRTAP2-3 interactions	CATSPER1 PHLDA1 CREB5	2.16e-04	95	25	3	int:KRTAP2-3
Interaction	POU3F1 interactions	POU3F2 POU3F3	2.49e-04	19	25	2	int:POU3F1
Interaction	TRIM8 interactions	CATSPER1 CBL RNF111	2.52e-04	100	25	3	int:TRIM8
Interaction	KRTAP2-4 interactions	CATSPER1 PHLDA1 CREB5	2.59e-04	101	25	3	int:KRTAP2-4
Interaction	KRTAP6-1 interactions	POU4F2 CATSPER1 CREB5	2.75e-04	103	25	3	int:KRTAP6-1
Interaction	POU3F2 interactions	POU3F2 POU3F3	2.77e-04	20	25	2	int:POU3F2
Interaction	RBP3 interactions	POU4F2 CREB5	2.77e-04	20	25	2	int:RBP3
Interaction	POU3F3 interactions	POU3F2 POU3F3	3.36e-04	22	25	2	int:POU3F3
Interaction	RIMBP3 interactions	CATSPER1 CREB5	3.36e-04	22	25	2	int:RIMBP3
Interaction	PCSK5 interactions	CACNA1A POU4F2 CREB5	3.52e-04	112	25	3	int:PCSK5
Interaction	GRN interactions	CACNA1A HRG POU4F2 NLK	3.71e-04	281	25	4	int:GRN
Interaction	KPRP interactions	POU4F2 CATSPER1 PHLDA1 CREB5	3.87e-04	284	25	4	int:KPRP
Interaction	RGS20 interactions	HRG CATSPER1 CREB5	4.10e-04	118	25	3	int:RGS20
Interaction	FRS3 interactions	CATSPER1 CBL CREB5	4.52e-04	122	25	3	int:FRS3
Interaction	KRTAP10-10 interactions	CATSPER1 CREB5	5.09e-04	27	25	2	int:KRTAP10-10
Interaction	EFEMP2 interactions	CACNA1A CATSPER1 CREB5	6.20e-04	136	25	3	int:EFEMP2
Interaction	KRTAP4-1 interactions	CATSPER1 CREB5	6.72e-04	31	25	2	int:KRTAP4-1
Interaction	FST interactions	CATSPER1 CREB5	7.16e-04	32	25	2	int:FST
Interaction	CYP21A2 interactions	POU4F2 CREB5	7.62e-04	33	25	2	int:CYP21A2
Interaction	KRTAP9-4 interactions	CATSPER1 CREB5	7.62e-04	33	25	2	int:KRTAP9-4
Interaction	SPRY2 interactions	CATSPER1 CBL CREB5	8.57e-04	152	25	3	int:SPRY2
Interaction	SPRY3 interactions	CATSPER1 CREB5	8.57e-04	35	25	2	int:SPRY3
Interaction	MMADHC interactions	POU4F2 CREB5	9.07e-04	36	25	2	int:MMADHC
Interaction	RGS19 interactions	POU4F2 CATSPER1	9.58e-04	37	25	2	int:RGS19
Interaction	FBLN5 interactions	HRG CREB5 RNF111	9.76e-04	159	25	3	int:FBLN5
Interaction	KRTAP10-5 interactions	POU4F2 CATSPER1 CREB5	9.93e-04	160	25	3	int:KRTAP10-5
Interaction	SDR16C5 interactions	HSFX1 NLK	1.01e-03	38	25	2	int:SDR16C5
Interaction	KRTAP6-3 interactions	POU4F2 PHLDA1 CREB5	1.01e-03	161	25	3	int:KRTAP6-3
Interaction	NOTCH2NLA interactions	CATSPER1 PHLDA1 CREB5 RNF111	1.16e-03	381	25	4	int:NOTCH2NLA
Interaction	PLSCR1 interactions	HRG CATSPER1 PHLDA1	1.22e-03	172	25	3	int:PLSCR1
Interaction	KRTAP10-8 interactions	POU4F2 CATSPER1 PHLDA1 CREB5	1.40e-03	401	25	4	int:KRTAP10-8
Interaction	SSC4D interactions	CATSPER1 CREB5	1.42e-03	45	25	2	int:SSC4D
Interaction	KRTAP1-3 interactions	CATSPER1 PHLDA1 CREB5	1.49e-03	184	25	3	int:KRTAP1-3
Interaction	SCN5A interactions	CACNA1A CBL	1.54e-03	47	25	2	int:SCN5A
Interaction	KRTAP19-2 interactions	POU4F2 CREB5	1.54e-03	47	25	2	int:KRTAP19-2
Interaction	KRTAP6-2 interactions	CATSPER1 PHLDA1 CREB5	1.56e-03	187	25	3	int:KRTAP6-2
Interaction	ALX4 interactions	POU4F2 CDX2	1.61e-03	48	25	2	int:ALX4
Interaction	KRTAP1-5 interactions	CATSPER1 CREB5	1.61e-03	48	25	2	int:KRTAP1-5
Interaction	MDFI interactions	CATSPER1 PHLDA1 CREB5 RNF111	1.81e-03	430	25	4	int:MDFI
Interaction	IGFBP6 interactions	POU4F2 CREB5	1.81e-03	51	25	2	int:IGFBP6
Interaction	ALOXE3 interactions	PLK2 RNF111	1.89e-03	52	25	2	int:ALOXE3
Interaction	SIVA1 interactions	CATSPER1 CREB5	1.89e-03	52	25	2	int:SIVA1
Interaction	KRT31 interactions	POU4F2 CATSPER1 PHLDA1 CREB5	2.19e-03	453	25	4	int:KRT31
Interaction	UBE2L3 interactions	CACNA1A CBL RNF111	2.20e-03	211	25	3	int:UBE2L3
Interaction	ADAMTSL4 interactions	POU4F2 CATSPER1 CREB5	2.38e-03	217	25	3	int:ADAMTSL4
Interaction	VWC2 interactions	POU4F2 CATSPER1	2.67e-03	62	25	2	int:VWC2
Interaction	KRTAP12-1 interactions	POU4F2 CATSPER1	2.75e-03	63	25	2	int:KRTAP12-1
GeneFamily	POU class homeoboxes and pseudogenes	POU3F2 POU3F3 POU4F2	2.02e-06	23	20	3	523
GeneFamily	Forkhead boxes	FOXL2 FOXB2	1.02e-03	43	20	2	508
Coexpression	BENPORATH_EED_TARGETS	SOX1 GATA6 HAND1 POU3F2 POU4F2 CDX2 FOXL2 VGLL2	5.64e-06	1059	26	8	M7617
Coexpression	RIZ_ERYTHROID_DIFFERENTIATION_HBZ	SOX1 POU3F2 POU3F3	6.58e-06	37	26	3	M802
Coexpression	RIZ_ERYTHROID_DIFFERENTIATION_HBZ	SOX1 POU3F2 POU3F3	6.58e-06	37	26	3	MM509
Coexpression	BENPORATH_ES_WITH_H3K27ME3	GATA6 CACNA1A HAND1 POU3F2 POU4F2 CDX2 FOXL2 VGLL2	8.23e-06	1115	26	8	M10371
Coexpression	CUI_DEVELOPING_HEART_LEFT_VENTRICULAR_CARDIOMYOCYTE	HAND1 PLK2 PHLDA1	8.35e-06	40	26	3	M39313
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3K27ME3	SOX1 HAND1 POU3F2 POU3F3 POU4F2 CDX2	2.01e-05	591	26	6	M2019
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3K27ME3	SOX1 HAND1 POU3F2 POU3F3 POU4F2 CDX2	2.21e-05	601	26	6	MM866
Coexpression	FAN_EMBRYONIC_CTX_EX_2_EXCITATORY_NEURON	POU3F2 PHLDA1	1.13e-04	16	26	2	M39025
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	HAND1 POU4F2 CDX2 FOXB2	1.42e-04	272	26	4	M1938
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	HAND1 POU4F2 CDX2 FOXB2	1.63e-04	282	26	4	MM822
Coexpression	DESCARTES_FETAL_HEART_SATB2_LRRC7_POSITIVE_CELLS	CACNA1A POU3F2 POU3F3	1.99e-04	115	26	3	M40201
Coexpression	RIZ_ERYTHROID_DIFFERENTIATION_HEMGN	SOX1 POU3F3	3.03e-04	26	26	2	M7999
Coexpression	RIZ_ERYTHROID_DIFFERENTIATION_HEMGN	SOX1 POU3F3	3.03e-04	26	26	2	MM510
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	POU4F2 CDX2 VGLL2 FOXB2	3.51e-04	345	26	4	M2009
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	POU4F2 CDX2 VGLL2 FOXB2	3.58e-04	347	26	4	MM860
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	GATA6 POU4F2 VGLL2 FOXB2	3.70e-04	350	26	4	M1949
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	GATA6 POU4F2 VGLL2 FOXB2	3.99e-04	357	26	4	MM828
Coexpression	GSE37605_TREG_VS_TCONV_NOD_FOXP3_FUSION_GFP_UP	PLK2 PHLDA1 RBM33	4.34e-04	150	26	3	M8796
Coexpression	BENPORATH_SUZ12_TARGETS	SOX1 GATA6 CACNA1A POU4F2 CDX2 FOXL2	4.36e-04	1035	26	6	M9898
Coexpression	SIMBULAN_UV_RESPONSE_NORMAL_DN	PHLDA1 MN1	4.90e-04	33	26	2	M16114
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500_k-means-cluster#3	HAND1 POU3F2 POU3F3 CDX2	8.93e-05	204	25	4	ratio_EB_vs_SC_500_K3
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_1000_k-means-cluster#5	GATA6 HAND1 POU3F2 POU3F3 CDX2	1.08e-04	416	25	5	ratio_EB_vs_SC_1000_K5
CoexpressionAtlas	FacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_1000_k-means-cluster#4	SHANK1 CACNA1A POU3F3 CREB5	1.26e-04	223	25	4	Facebase_RNAseq_e9.5_Facial Mesenchyne_1000_K4
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#4	SHANK1 CACNA1A POU3F3 CREB5	1.47e-04	232	25	4	Facebase_RNAseq_e9.5_Maxillary Arch_1000_K4
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#2	SHANK1 CACNA1A POU3F3 CREB5	1.92e-04	249	25	4	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_1000_K2
CoexpressionAtlas	AravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_500_k-means-cluster#2	HAND1 POU3F2 POU3F3 CDX2	2.11e-04	255	25	4	Arv_EB-LF_500_K2
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#1	SHANK1 CACNA1A POU3F3 CREB5	2.11e-04	255	25	4	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_1000_K1
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_EmbryoidBody_fromBlastocyst-derived-humanEmbryonicStemCells_top-relative-expression-ranked_100	HAND1 POU3F2 CDX2	2.16e-04	100	25	3	PCBC_EB_blastocyst_100
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_EmbryoidBody_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_100	HAND1 POU3F2 CDX2	2.16e-04	100	25	3	PCBC_EB_fibroblast_100
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_EmbryoidBody_top-relative-expression-ranked_500	SOX1 HAND1 POU3F2 POU3F3 CDX2	2.46e-04	496	25	5	PCBC_EB_500
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_EmbryoidBody_fromBlastocyst-derived-humanEmbryonicStemCells_top-relative-expression-ranked_500	SOX1 HAND1 POU3F2 POU3F3 CDX2	2.46e-04	496	25	5	PCBC_EB_blastocyst_500
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500	GATA6 HAND1 POU3F2 POU3F3 CDX2	2.51e-04	498	25	5	PCBC_ratio_EB_vs_SC_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#5	CACNA1A POU3F3 CREB5	4.07e-04	124	25	3	Facebase_RNAseq_e10.5_Medial Nasal Eminence_1000_K5
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GATA6 PHLDA1 MN1 CREB5	4.46e-06	192	26	4	0e7e55505bd5454d7cf952a63fdcb46ec76f1973
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GATA6 PHLDA1 MN1 CREB5	4.56e-06	193	26	4	025836c5c5a711e477c326559e618e47cae42d11
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-Immature_CPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 POU3F3 PHLDA1 MN1	5.04e-06	198	26	4	32d58379a89be19b6b1a494bf033416546771c19
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal-Immature_CPNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 POU3F3 PHLDA1 MN1	5.04e-06	198	26	4	4e598aab92141e7d32ec963291ddeed14a21beba
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Cortical_neuron\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1A POU3F2 PLK2 MN1	5.25e-06	200	26	4	5b3df61ff421846ef4cabf1bd5355534c8b95509
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-Neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 PHLDA1 MN1	6.68e-05	136	26	3	b46450292e0cd549eb3bafdd3fed22f41d85bfbe
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SHANK1 POU3F2 MN1	6.82e-05	137	26	3	ed81624b9167255ce88dcf6ad7f1636376ea0525
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell-Mesenchymal_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SHANK1 POU3F2 MN1	6.82e-05	137	26	3	47859aa25f32367461c1ec75ed9060bee430c6b7
ToppCell	TCGA-Breast-Metastatic-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	HRG CATSPER1 FOXL2	8.75e-05	149	26	3	2e9b898f3df22f8e872f2c278eff454c39e55b3b
ToppCell	TCGA-Breast-Metastatic\|TCGA-Breast / Sample_Type by Project: Shred V9	HRG CATSPER1 FOXL2	8.75e-05	149	26	3	144ac2c458209ce510674bc2f83eb4c8e4d3c953
ToppCell	TCGA-Breast-Metastatic-Breast_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	HRG CATSPER1 FOXL2	8.75e-05	149	26	3	c7dc495141cd921b6b6f291a68851b7b807d0d0a
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Trm_Th1/Th17\|GI_large-bowel / Manually curated celltypes from each tissue	PHLDA1 ZNF652 PRR7	1.51e-04	179	26	3	6359f30005b17dc5b5c4c8f3a6a38c87ccfe4ee9
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX1 POU3F3 POU4F2	1.63e-04	184	26	3	7712f2e1fae5cdde2d4e355b860dc8536b28e4f6
ToppCell	Control-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	PHLDA1 MN1 CREB5	1.66e-04	185	26	3	0af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-cycling_neuroblast\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX1 POU3F3 POU4F2	1.74e-04	188	26	3	33afe31b1093d317dc38c324197c6e91bf6c39d3
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GATA6 PLK2 MN1	1.88e-04	193	26	3	cd45118ced91b10baed3b1068d4673ec99824b86
ToppCell	21-Trachea-Epithelial-Epithelial\|Trachea / Age, Tissue, Lineage and Cell class	SOX1 POU3F2 POU3F3	1.88e-04	193	26	3	9a8bb44a37f3202e3123a6680bd5545dc91a6d40
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SOX1 POU3F2 POU3F3	1.91e-04	194	26	3	68d15917ae222cba0ad9e716d29eebb6c5f00f69
ToppCell	(3)_Chondrocytes-(34)_Chondro-progen\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PHLDA1 MN1 CREB5	1.94e-04	195	26	3	d00cb2fab25f2026a9668a7f0686938a2e7155e2
ToppCell	15-Trachea-Epithelial-Epithelial\|Trachea / Age, Tissue, Lineage and Cell class	POU3F2 POU3F3 MN1	1.94e-04	195	26	3	9e9283a397f56732a0a5f2e2527f154d4c2dd56a
ToppCell	Mesenchymal_cells-Myofibroblasts\|World / Lineage and Cell class	PLK2 VGLL2 CREB5	1.97e-04	196	26	3	2c0f429ae18c2df05c33ddf58dcc2c94b819b9a1
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-PFC\|World / Primary Cells by Cluster	POU3F2 POU3F3 MN1	2.00e-04	197	26	3	2c3b0072f8e1e09c77a85c6fc3133d1796932fb2
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-PFC-29\|World / Primary Cells by Cluster	POU3F2 POU3F3 MN1	2.00e-04	197	26	3	c5bc0e7eb85642b270efc2ba92b13a736af22052
ToppCell	(3)_Chondrocytes-(34)_Chondro-progen\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	PHLDA1 MN1 CREB5	2.00e-04	197	26	3	012c49a57f9c2a3dfa988cd3882c8c6b7ef3a5ad
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	POU3F3 POU4F2 CREB5	2.03e-04	198	26	3	c8272ac4d90f2367f538f66db40de911ad73ea7f
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-Neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 PHLDA1 MN1	2.03e-04	198	26	3	90ebefc9ba8dc2a81471e5693384f5ce56f06298
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	POU3F2 POU3F3 MN1	2.03e-04	198	26	3	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Mesothelium\|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X	GATA6 PLK2 PHLDA1	2.06e-04	199	26	3	6cfefd81e8a1a883fb4279ac4ab0b298ed2a0817
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	POU3F3 POU4F2 CREB5	2.06e-04	199	26	3	8d13a9ea87f685b5a34b84c4571db6be753cf2d9
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	POU3F3 POU4F2 CREB5	2.06e-04	199	26	3	9940f347973bf976ee23fb4b1cf1f349d96c21df
ToppCell	Transverse-(2)_B_cell-(24)_B_cell_cycling\|Transverse / shred on region, Cell_type, and subtype	CREB5 NLK RNF111	2.09e-04	200	26	3	e3f9736227151f23f0e331eec0a7a15ce464b517
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related\|10w / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 PLK2 PHLDA1	2.09e-04	200	26	3	8f5d98f962ddd8c4658c89ff8a2894de1228562a
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 POU3F3 MN1	2.09e-04	200	26	3	8795920911ee75c09a97cc948c14ad7301b27796
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-OPC_related-Oligodendrocyte/OPC\|2m / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 PLK2 CREB5	2.09e-04	200	26	3	3c9a2f02294a9fb892b89e856291bd6423ffa0a9
ToppCell	Transverse-B_cell-B_cell_cycling\|Transverse / Region, Cell class and subclass	CREB5 NLK RNF111	2.09e-04	200	26	3	0e270f8019d9f22068ca426d661937262a5cd331
ToppCell	COVID-19-COVID-19_Convalescent-Myeloid-cDC\|COVID-19_Convalescent / Disease, condition lineage and cell class	PLK2 MN1 CREB5	2.09e-04	200	26	3	ac9d7927863348a752444d2e80269a5eead943b7
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	POU3F3 POU4F2 CREB5	2.09e-04	200	26	3	553e9612874480f4d2a45671462e266cd0a09321
ToppCell	droplet-Skin-nan-21m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLDA1 MN1 CREB5	2.09e-04	200	26	3	69295705fc614c2687f2b6c8e6aa0c6717841008
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 POU3F3 PHLDA1	2.09e-04	200	26	3	3d134ae3c48ff4d1849db4fbe44ff73fb6c8c779
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-OPC_related\|2m / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 PLK2 CREB5	2.09e-04	200	26	3	8e49e7e9b02d8411e4ffae1f5113a2c18f5bf179
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 POU3F3 MN1	2.09e-04	200	26	3	fd6b4ff4330db11c03f1eb4e06b43a162326f744
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related-Oligodendrocyte/OPC\|10w / Sample Type, Dataset, Time_group, and Cell type.	POU3F2 PLK2 PHLDA1	2.09e-04	200	26	3	345f1eac498cc87fd7bf08e7312608b2d6fe1dd7
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PLK2 PHLDA1 ZNF652	2.09e-04	200	26	3	7c2d499af60654b7b28f172ac2c914ad49fb74b4
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC\|Multiple_Sclerosis / Disease, condition lineage and cell class	CACNA1A PHLDA1 PRR7	2.09e-04	200	26	3	ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
Disease	Barrett's esophagus (is_marker_for)	GATA6 CDX2	3.77e-05	11	25	2	DOID:9206 (is_marker_for)
Disease	semaphorin-3A measurement	HRG NLK	7.19e-05	15	25	2	EFO_0008278
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	GATA6 CBL	1.88e-04	24	25	2	DOID:3827 (biomarker_via_orthology)
Disease	electrocardiography	GATA6 HRG HAND1 VGLL2	9.65e-04	530	25	4	EFO_0004327
Disease	atopic eczema	CREB5 ZNF652 RNF111	1.23e-03	252	25	3	EFO_0000274
Disease	thyroid stimulating hormone measurement	POU3F2 CREB5 ZNF652	2.50e-03	323	25	3	EFO_0004748
Disease	cerebrospinal fluid biomarker measurement	HRG CATSPER1	2.99e-03	96	25	2	EFO_0006794

Protein segments in the cluster

Peptide	Gene	Start	Entry
HHHHHHHHHPPPPDK	CACNA1A	2211	O00555
HHHPHHHPHHPAAAP	CDX2	116	Q99626
DHHPSEYHHGDHPHH	CATSPER1	271	Q8NEC5
PPQHPPQHQHHHHHH	RBM33	626	Q96EV2
PHHPYPHQHQHPAHH	CREB5	286	Q02930
GPGGHLHPHHHHHPH	FOXB2	131	Q5VYV0
HAAAHHHHHHHPPQP	FOXB2	151	Q5VYV0
PHGHHPHAHHPHEHD	HRG	361	P04196
PHGHHPHGHHPHGHH	HRG	381	P04196
PHGHHPHGHHPHGHH	HRG	386	P04196
PHGHHPHGHHPHGHH	HRG	391	P04196
PHGHHPHGHHPHCHD	HRG	396	P04196
HPHPHAHHLHAAAAP	FOXL2	291	P58012
HHHHHPHPAHPMLHE	HAND1	11	O96004
HHHHLPHLPPPHLHH	NLK	31	Q9UBE8
APAHAHSHPHVHVHP	PRR7	86	Q8TB68
PAQPHAHAHPHPHHH	PRR7	106	Q8TB68
AHAHPHPHHHALPHP	PRR7	111	Q8TB68
HHHHHHHHPSPYSPY	GATA6	326	Q92908
HHHHHHHLSPHPPGT	CBL	36	P22681
HHAHPHPPHPHHAQG	POU3F3	276	P20264
HPGSHHPHQHHPHFG	MN1	101	Q10571
FPHLPALHHHCPHSH	HSFX1	386	Q9UBD0
HHHHPPHHSPFKPDA	POU4F2	126	Q12837
GAHPHAHPAHPHPHH	SOX1	221	O00570
AHPAHPHPHHPHAHP	SOX1	226	O00570
EPHHADHHPHPHSHP	POU3F2	221	P20265
AHHHPPHHHHHHAPP	SHANK1	996	Q9Y566
PHHHHHHAPPPQPHH	SHANK1	1001	Q9Y566
TPHHHSPHAHHEPVL	SHANK1	1391	Q9Y566
TEPWHHAHPHHAHPH	VGLL2	191	Q8N8G2
HAHPHHAHPHHPYAL	VGLL2	196	Q8N8G2
HHHHHTPHPAVPVSP	RNF111	516	Q6ZNA4
YPHPHPHPHSHPHSH	PHLDA1	351	Q8WV24
HPHSHPHPHPHPHPH	PHLDA1	361	Q8WV24
APHSAQTHPHHHHHP	SKOR2	646	Q2VWA4
HHHHHHHHPPQPPSP	SKOR2	661	Q2VWA4
VPPAAPHHHHHHSHS	PLK2	51	Q9NYY3
PFSHLHIHPHPHHPH	ZNF652	546	Q9Y2D9