Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidic acid binding	PITPNM1 RAPGEF2 PLEKHN1	5.24e-05	24	61	3	GO:0070300
GeneOntologyMolecularFunction	type 2 fibroblast growth factor receptor binding	FGF8 FGF10	9.13e-05	5	61	2	GO:0005111
Domain	ZF_PHD_2	KAT6A ASXL2 KMT2E SP110	2.46e-04	95	60	4	PS50016
Domain	ZF_PHD_1	KAT6A ASXL2 KMT2E SP110	2.56e-04	96	60	4	PS01359
Domain	DUF4599	SPATA31D4 SPATA31D3	6.56e-04	12	60	2	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D3	6.56e-04	12	60	2	IPR027970
Domain	Znf_FYVE_PHD	KAT6A WDFY3 KMT2E SP110	1.28e-03	147	60	4	IPR011011
Domain	ARM-like	PDS5B CLASP1 RRP12 DAXX WDFY3	1.74e-03	270	60	5	IPR011989
Domain	PHD	KAT6A KMT2E SP110	1.81e-03	75	60	3	PF00628
Domain	Znf_PHD-finger	KAT6A KMT2E SP110	2.10e-03	79	60	3	IPR019787
Domain	FGF	FGF8 FGF10	2.25e-03	22	60	2	SM00442
Domain	FGF	FGF8 FGF10	2.25e-03	22	60	2	PF00167
Domain	HBGF_FGF	FGF8 FGF10	2.25e-03	22	60	2	PS00247
Domain	Fibroblast_GF_fam	FGF8 FGF10	2.25e-03	22	60	2	IPR002209
Domain	IL-1_fam/FGF_fam	FGF8 FGF10	2.46e-03	23	60	2	IPR028142
Domain	PHD	KAT6A KMT2E SP110	2.94e-03	89	60	3	SM00249
Domain	-	RAG1 CBLL2 KAT6A WDFY3 KMT2E SP110	3.12e-03	449	60	6	3.30.40.10
Domain	Znf_PHD	KAT6A KMT2E SP110	3.13e-03	91	60	3	IPR001965
Domain	Znf_RING/FYVE/PHD	RAG1 CBLL2 KAT6A WDFY3 KMT2E SP110	3.48e-03	459	60	6	IPR013083
Domain	Znf_C2H2-like	RAG1 ZNF556 CBLL2 ATXN7 APTX ZNF197 ZKSCAN4 ZNF292	3.78e-03	796	60	8	IPR015880
Domain	ZnF_C2H2	RAG1 ZNF556 CBLL2 ATXN7 APTX ZNF197 ZKSCAN4 ZNF292	4.14e-03	808	60	8	SM00355
Domain	-	PDS5B CLASP1 RRP12 WDFY3	5.63e-03	222	60	4	1.25.10.10
Domain	Cytokine_IL1-like	FGF8 FGF10	5.96e-03	36	60	2	IPR008996
Pathway	WP_HEART_DEVELOPMENT	PITX2 FGF8 FGF10	4.47e-04	46	46	3	MM15884
Pathway	WP_HEART_DEVELOPMENT	PITX2 FGF8 FGF10	4.77e-04	47	46	3	M39610
Pathway	REACTOME_FGFRL1_MODULATION_OF_FGFR1_SIGNALING	FGF8 FGF10	7.94e-04	13	46	2	M27540
Pathway	REACTOME_FGFRL1_MODULATION_OF_FGFR1_SIGNALING	FGF8 FGF10	7.94e-04	13	46	2	MM15262
Pathway	REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR1	FGF8 FGF10	1.21e-03	16	46	2	M48007
Pathway	REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR1	FGF8 FGF10	1.21e-03	16	46	2	MM15233
Pathway	REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION	FGF8 FGF10	1.37e-03	17	46	2	MM17066
Pathway	REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR2	FGF8 FGF10	1.37e-03	17	46	2	MM15234
Pathway	WP_MESODERMAL_COMMITMENT_PATHWAY	UBR5 BCORL1 PITX2 FGF8	1.53e-03	153	46	4	M39546
Pathway	REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR2	FGF8 FGF10	1.54e-03	18	46	2	M27508
Pathway	REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION	FGF8 FGF10	1.54e-03	18	46	2	M1092
Pathway	REACTOME_FGFR2_LIGAND_BINDING_AND_ACTIVATION	FGF8 FGF10	1.54e-03	18	46	2	MM14724
Pathway	WP_BMP_SIGNALING_PATHWAY_IN_EYELID_DEVELOPMENT	PITX2 FGF10	1.91e-03	20	46	2	MM15907
Pathway	WP_BMP_SIGNALING_IN_EYELID_DEVELOPMENT	PITX2 FGF10	1.91e-03	20	46	2	M39624
Pathway	REACTOME_FGFR2_LIGAND_BINDING_AND_ACTIVATION	FGF8 FGF10	1.91e-03	20	46	2	M27062
Pathway	REACTOME_SHC_MEDIATED_CASCADE_FGFR1	FGF8 FGF10	1.91e-03	20	46	2	MM15237
Pathway	REACTOME_PI_3K_CASCADE_FGFR1	FGF8 FGF10	2.10e-03	21	46	2	M27512
Pathway	REACTOME_SHC_MEDIATED_CASCADE_FGFR1	FGF8 FGF10	2.10e-03	21	46	2	M27511
Pathway	REACTOME_PI_3K_CASCADE_FGFR1	FGF8 FGF10	2.10e-03	21	46	2	MM15238
Pathway	REACTOME_SHC_MEDIATED_CASCADE_FGFR2	FGF8 FGF10	2.10e-03	21	46	2	MM15242
Pathway	REACTOME_FRS_MEDIATED_FGFR1_SIGNALING	FGF8 FGF10	2.31e-03	22	46	2	MM15239
Pathway	REACTOME_PI_3K_CASCADE_FGFR2	FGF8 FGF10	2.31e-03	22	46	2	MM15240
Pathway	REACTOME_PI_3K_CASCADE_FGFR2	FGF8 FGF10	2.52e-03	23	46	2	M27514
Pathway	REACTOME_FRS_MEDIATED_FGFR1_SIGNALING	FGF8 FGF10	2.52e-03	23	46	2	M27513
Pathway	REACTOME_FRS_MEDIATED_FGFR2_SIGNALING	FGF8 FGF10	2.52e-03	23	46	2	MM15243
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PITPNM1 TUBGCP6 PDS5B MSH6 CLASP1 ATXN7 RRP12 CCNL1 CTDP1 OTUD4 DAXX ESPL1 THRAP3 PPL	8.88e-11	774	63	14	15302935
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TUBGCP6 MSH6 EIF4ENIF1 UBR5 ATXN7 NOL12 KAT6A SREK1 WDFY3 RAPGEF2 TEP1 PLEKHN1 SP110	8.43e-08	1116	63	13	31753913
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	MSH6 UBR5 NOL12 RRP12 THRAP3 PPL	2.30e-06	210	63	6	16565220
Pubmed	The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome.	PITX2 FGF8 FGF10	2.54e-06	15	63	3	12413905
Pubmed	Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity.	RAG1 KAT6A	3.23e-06	2	63	2	38237601
Pubmed	Embryonic development of mouse external genitalia: insights into a unique mode of organogenesis.	FGF8 FGF10	3.23e-06	2	63	2	12004962
Pubmed	Mutations in fibroblast growth factor (FGF8) and FGF10 identified in patients with conotruncal defects.	FGF8 FGF10	3.23e-06	2	63	2	32664970
Pubmed	Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells.	FGF8 FGF10	3.23e-06	2	63	2	11890684
Pubmed	Pitx1 and Pitx2 are required for development of hindlimb buds.	PITX2 FGF8 FGF10	4.53e-06	18	63	3	12441290
Pubmed	Tbx1 regulates oral epithelial adhesion and palatal development.	PITX2 FGF8 FGF10	6.32e-06	20	63	3	22371266
Pubmed	FGF8, FGF10 and FGF receptor 2 in foreskin of children with hypospadias: an analysis of immunohistochemical expression patterns and gene transcription.	FGF8 FGF10	9.68e-06	3	63	2	31718875
Pubmed	Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.	FGF8 FGF10	9.68e-06	3	63	2	9784490
Pubmed	The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.	PITX2 FGF8 FGF10	9.78e-06	23	63	3	26321200
Pubmed	Tbx3 is required for outflow tract development.	PITX2 FGF8 FGF10	1.12e-05	24	63	3	18723448
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MSH6 EIF4ENIF1 CLASP1 ATXN7 RRP12 APTX CCNL1 PTDSS1 OTUD4 DAXX CTNNA2 SREK1	1.35e-05	1497	63	12	31527615
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PDS5B MSH6 KAT6A CCNL1 BCORL1 DAXX ZKSCAN4 ZNF292	1.39e-05	608	63	8	36089195
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	EIF4ENIF1 CLASP1 UBR5 PI4KB OTUD4 DAXX RAPGEF2 ESPL1 FRMD4B THRAP3	1.64e-05	1038	63	10	26673895
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PDS5B MSH6 DENND4A CLASP1 UBR5 PI4KB RRP12 OTUD4 ASXL2 SREK1 THRAP3	1.76e-05	1284	63	11	17353931
Pubmed	Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.	PITX2 FGF8 FGF10	1.80e-05	28	63	3	15901664
Pubmed	Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy.	FGF8 FGF10	1.93e-05	4	63	2	17000704
Pubmed	FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis.	FGF8 FGF10	1.93e-05	4	63	2	15063181
Pubmed	FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias.	FGF8 FGF10	1.93e-05	4	63	2	17264867
Pubmed	Involvement of FGF and BMP family proteins and VEGF in early human kidney development.	FGF8 FGF10	1.93e-05	4	63	2	18437684
Pubmed	Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma.	PITX2 DAXX	1.93e-05	4	63	2	32606567
Pubmed	WNT5A signaling affects pituitary gland shape.	PITX2 FGF8 FGF10	2.00e-05	29	63	3	15037319
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PDS5B MSH6 CLASP1 NOL12 RRP12 PTDSS1 SREK1 THRAP3 RPL17 ZNF292	2.33e-05	1082	63	10	38697112
Pubmed	Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis.	PITX2 FGF8 FGF10	2.71e-05	32	63	3	29028795
Pubmed	Tbx1 is necessary for palatal elongation and elevation.	FGF8 FGF10	3.22e-05	5	63	2	20214979
Pubmed	Fgf8 is required for outgrowth and patterning of the limbs.	FGF8 FGF10	3.22e-05	5	63	2	11101845
Pubmed	Expression survey of genes critical for tooth development in the human embryonic tooth germ.	PITX2 FGF8	3.22e-05	5	63	2	17394220
Pubmed	Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1.	RAPGEF2 CDH5	3.22e-05	5	63	2	19635461
Pubmed	The migrating gubernaculum grows like a "limb bud".	FGF8 FGF10	3.22e-05	5	63	2	18280296
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	MRPL23 PDS5B CLASP1 RRP12 SREK1 RGS12 ZNF292	3.23e-05	497	63	7	36774506
Pubmed	Gene expression profiling in the developing secondary palate in the absence of Tbx1 function.	FGF8 FGF10 TNNI2	3.26e-05	34	63	3	29866044
Pubmed	The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.	UBR5 CCNL1 PTDSS1 SREK1	3.92e-05	104	63	4	31365120
Pubmed	Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH.	PITX2 FGF8	4.82e-05	6	63	2	10411502
Pubmed	FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells.	FGF8 FGF10	4.82e-05	6	63	2	16470835
Pubmed	Tbx5 Buffers Inherent Left/Right Asymmetry Ensuring Symmetric Forelimb Formation.	FGF8 FGF10	4.82e-05	6	63	2	27992425
Pubmed	Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage.	PITX2 FGF8	4.82e-05	6	63	2	10625557
Pubmed	Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract.	FGF8 FGF10	4.82e-05	6	63	2	15789410
Pubmed	A genetic link between Tbx1 and fibroblast growth factor signaling.	FGF8 FGF10	4.82e-05	6	63	2	12223416
Pubmed	Normal limb development in conditional mutants of Fgf4.	FGF8 FGF10	4.82e-05	6	63	2	10662638
Pubmed	Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice.	FGF8 FGF10	4.82e-05	6	63	2	21937598
Pubmed	Intercellular growth factor signaling and the development of mouse tracheal submucosal glands.	FGF8 FGF10	4.82e-05	6	63	2	15973734
Pubmed	Lhx9 gene expression during early limb development in mice requires the FGF signalling pathway.	FGF8 FGF10	4.82e-05	6	63	2	26220830
Pubmed	The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility.	CTNNA2 CDH5	4.82e-05	6	63	2	12975353
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	SPATA31D4 SPATA31D3 ATXN7 KMT2E ZNF292	6.62e-05	233	63	5	37704626
Pubmed	Mesodermal expression of Moz is necessary for cardiac septum development.	KAT6A PITX2	6.74e-05	7	63	2	25912687
Pubmed	Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4.	FGF8 FGF10	6.74e-05	7	63	2	11180951
Pubmed	Tbx5 is required for forelimb bud formation and continued outgrowth.	FGF8 FGF10	6.74e-05	7	63	2	12736217
Pubmed	Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown.	RAG1 CDH5	6.74e-05	7	63	2	37253744
Pubmed	Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors.	RAG1 CDH5	6.74e-05	7	63	2	27695000
Pubmed	Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.	FGF8 FGF10	6.74e-05	7	63	2	20035084
Pubmed	FGF9-Pitx2-FGF10 signaling controls cecal formation in mice.	PITX2 FGF10	6.74e-05	7	63	2	22819677
Pubmed	Function of Rieger syndrome gene in left-right asymmetry and craniofacial development.	PITX2 FGF8	6.74e-05	7	63	2	10499585
Pubmed	Developmental origins of precocial forelimbs in marsupial neonates.	FGF8 FGF10	6.74e-05	7	63	2	21098569
Pubmed	Wnt5a is required for cardiac outflow tract septation in mice.	FGF8 FGF10	6.74e-05	7	63	2	17515859
Pubmed	Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10.	FGF8 FGF10	6.74e-05	7	63	2	17467687
Pubmed	Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.	FGF8 FGF10	6.74e-05	7	63	2	34643182
Pubmed	Morphogenesis.	FGF8 FGF10	8.98e-05	8	63	2	9988217
Pubmed	Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development.	FGF8 FGF10	8.98e-05	8	63	2	10802662
Pubmed	Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema regions.	PITX2 FGF8	8.98e-05	8	63	2	10415326
Pubmed	Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation.	FGF8 FGF10	8.98e-05	8	63	2	15069081
Pubmed	Sonic hedgehog signaling from the urethral epithelium controls external genital development.	FGF8 FGF10	8.98e-05	8	63	2	12074550
Pubmed	Development of the mammalian urethra is controlled by Fgfr2-IIIb.	FGF8 FGF10	8.98e-05	8	63	2	15843416
Pubmed	Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice.	FGF8 FGF10	8.98e-05	8	63	2	16687131
Pubmed	Functional evolutionary history of the mouse Fgf gene family.	FGF8 FGF10	8.98e-05	8	63	2	18058912
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PDS5B CLASP1 UBR5 RRP12 OTUD4 ASXL2	9.58e-05	407	63	6	12693553
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	DENND4A CLASP1 PI4KB THRAP3 RGS12	1.01e-04	255	63	5	15324660
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	MRPL23 NOL12 RRP12 KAT6A SREK1 RPL17	1.09e-04	417	63	6	36537216
Pubmed	The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs.	FGF8 FGF10	1.15e-04	9	63	2	10518490
Pubmed	Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development.	FGF8 FGF10	1.15e-04	9	63	2	17164422
Pubmed	Fgf10 is essential for limb and lung formation.	FGF8 FGF10	1.15e-04	9	63	2	9916808
Pubmed	Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates.	PITX2 FGF8	1.15e-04	9	63	2	15371312
Pubmed	Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation.	FGF8 FGF10	1.15e-04	9	63	2	10804187
Pubmed	Embryonic retinoic acid synthesis is essential for early mouse post-implantation development.	FGF8 FGF10	1.15e-04	9	63	2	10192400
Pubmed	Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.	FGF8 FGF10	1.15e-04	9	63	2	12569130
Pubmed	An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome.	FGF8 FGF10	1.15e-04	9	63	2	12223415
Pubmed	Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth.	FGF8 FGF10	1.15e-04	9	63	2	22662233
Pubmed	Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod.	FGF8 FGF10	1.15e-04	9	63	2	14668414
Pubmed	FGF8 initiates inner ear induction in chick and mouse.	FGF8 FGF10	1.15e-04	9	63	2	15741321
Pubmed	Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.	FGF8 FGF10	1.15e-04	9	63	2	23633510
Pubmed	Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.	PITX2 FGF8 FGF10	1.39e-04	55	63	3	28807898
Pubmed	The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.	FGF8 FGF10	1.44e-04	10	63	2	15328019
Pubmed	Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome.	FGF8 FGF10	1.44e-04	10	63	2	20110535
Pubmed	The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud.	FGF8 FGF10	1.44e-04	10	63	2	9651475
Pubmed	Differential perturbation of the Fgf/Erk1/2 and Shh pathways in the C57BL/6N and SWV embryonic limb buds after mid-gestational cadmium chloride administration.	FGF8 FGF10	1.44e-04	10	63	2	17707671
Pubmed	Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development.	FGF8 FGF10	1.44e-04	10	63	2	20727874
Pubmed	Slc26a9P2ACre : a new CRE driver to regulate gene expression in the otic placode lineage and other FGFR2b-dependent epithelia.	FGF8 FGF10	1.44e-04	10	63	2	32541002
Pubmed	Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis.	PITX2 FGF8	1.44e-04	10	63	2	17519333
Pubmed	Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors.	FGF8 FGF10	1.44e-04	10	63	2	15340846
Pubmed	Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse.	PITX2 FGF10	1.44e-04	10	63	2	14697353
Pubmed	The canonical Wnt/β-catenin signaling pathway regulates Fgf signaling for early facial development.	FGF8 FGF10	1.44e-04	10	63	2	21070765
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MSH6 UBR5 RRP12 DAXX ESPL1 RPL17	1.46e-04	440	63	6	34244565
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	DENND4A EIF4ENIF1 CLASP1 UBR5 PI4KB RAPGEF2	1.58e-04	446	63	6	24255178
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PDS5B MSH6 CLASP1 UBR5 BCORL1 ASXL2 ZKSCAN4 THRAP3 ZNF292	1.60e-04	1103	63	9	34189442
Pubmed	BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling.	FGF8 FGF10	1.76e-04	11	63	2	17537800
Pubmed	Fibroblast growth factor-derived peptides: functional agonists of the fibroblast growth factor receptor.	FGF8 FGF10	1.76e-04	11	63	2	18199118
Pubmed	Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors.	FGF8 FGF10	1.76e-04	11	63	2	15469978
Pubmed	Advanced cardiac morphogenesis does not require heart tube fusion.	PITX2 FGF10	1.76e-04	11	63	2	15361625
Cytoband	8q22	UBR5 PTDSS1	1.99e-04	15	64	2	8q22
Cytoband	9q21.32	SPATA31D4 SPATA31D3	3.22e-04	19	64	2	9q21.32
Cytoband	Ensembl 112 genes in cytogenetic band chr3p14	PTPRG ATXN7 FRMD4B	1.01e-03	140	64	3	chr3p14
GeneFamily	PHD finger proteins	KAT6A KMT2E SP110	1.03e-03	90	40	3	88
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	PDS5B DENND4A UBR5 ATXN7 KAT6A CCNL1 PTDSS1 OTUD4 DAXX ASXL2 KMT2E SP110 THRAP3 RPL17 ZNF292	1.17e-06	1492	61	15	M40023
Coexpression	NAGASHIMA_NRG1_SIGNALING_DN	PDS5B GPR87 ZKSCAN4 ZNF292	8.28e-06	55	61	4	M17600
Coexpression	MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP	RRP12 PTDSS1 OTUD4 SREK1 ZKSCAN4 ESPL1 CDH5	4.45e-05	408	61	7	M11891
Coexpression	MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP	RRP12 PTDSS1 OTUD4 SREK1 ZKSCAN4 ESPL1 CDH5	4.95e-05	415	61	7	MM1028
Coexpression	GSE34156_UNTREATED_VS_6H_NOD2_LIGAND_TREATED_MONOCYTE_DN	CCNL1 DAXX RAPGEF2 SP110 FRMD4B	5.81e-05	177	61	5	M8666
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	CLASP1 UBR5 KAT6A OTUD4 WDFY3 RAPGEF2	7.00e-05	300	61	6	M8702
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	DENND4A ATXN7 RRP12 CCNL1 SREK1	7.72e-06	192	63	5	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	CCNL1 SREK1 KMT2E SP110 ZNF292	8.75e-06	197	63	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	CCNL1 SREK1 KMT2E SP110 ZNF292	8.97e-06	198	63	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCNL1 SREK1 KMT2E SP110 ZNF292	8.97e-06	198	63	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CCNL1 SREK1 KMT2E SP110 ZNF292	9.41e-06	200	63	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Signet-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	PITPNM1 SRRM5 CTDP1 MEIOSIN	1.68e-05	108	63	4	cac2108956e0c7b0326b8bf75033528eb1025480
Disease	hypospadias (biomarker_via_orthology)	FGF8 FGF10	5.28e-05	6	56	2	DOID:10892 (biomarker_via_orthology)
Disease	Cardiovascular Abnormalities	FGF8 ZNF292	4.17e-04	16	56	2	C0243050
Disease	DiGeorge syndrome (implicated_via_orthology)	KAT6A FGF8	5.93e-04	19	56	2	DOID:11198 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	WDFY3 KMT2E ZNF292	7.44e-04	93	56	3	C1535926
Disease	Adenoid Cystic Carcinoma	KAT6A BCORL1 ESPL1	9.19e-04	100	56	3	C0010606
Disease	Huntington disease, disease progression measurement	ATRNL1 PTDSS1	1.49e-03	30	56	2	EFO_0008336, MONDO_0007739
Disease	attention deficit hyperactivity disorder, bipolar disorder	PTPRG ATRNL1	1.59e-03	31	56	2	EFO_0003888, MONDO_0004985

Protein segments in the cluster

Peptide	Gene	Start	Entry
NRHGSAVQIRRRKAS	PTPRG	41	P23470
RESQTRKKVNHSRGT	CTDP1	336	Q9Y5B0
RQRKCRRQHSTGRKP	LINC00242	121	Q5T6M2
TGRLQRTRKKGHSTN	CATSPER1	406	Q8NEC5
RKVRKTQRDTQYRSH	BCORL1	1266	Q5H9F3
HRKRKRSGNSDSIER	APTX	126	Q7Z2E3
NRHGHKRKKSRSRSQ	CCNL1	461	Q9UK58
RRHKRARKQVTSASL	CBLL2	136	Q8N7E2
RRRLRKQARAHGKSV	CDH5	621	P33151
RKKRRARLQGTSSHS	DAXX	391	Q9UER7
GKKSFQRSERLHTRQ	ASXL2	246	Q76L83
TRNIQSRCFRKRHKS	DENND4A	1001	Q7Z401
ARQHKRRAQARISSK	RAG1	246	P15918
SKSKQHRVSRRAQQR	PDS5B	1341	Q9NTI5
TSKAQRRRLTGKARH	NOL12	196	Q9UGY1
QRKSSHVGDRKGSRR	OTUD4	491	Q01804
KSTLHAREKRQQTRG	MAGEB3	6	O15480
NSLRRQHLRKGKATR	MTG1	161	Q9BT17
NGRRSHVSKRARLQS	PPL	816	O60437
NRTKQRKSFSRSRTH	KMT2E	646	Q8IZD2
RKSFSRSRTHIGQQR	KMT2E	651	Q8IZD2
RKRHQQRSTVTAART	LRRC4	551	Q9HBW1
THLGQRSVNRKRAKR	TUBGCP6	21	Q96RT7
RQRHSKHRTSDQRKT	LILRB3	466	O75022
QGSRRSSRQIKKRRV	MSH6	236	P52701
TKARRFSRQHNRIVK	MEIOSIN	591	C9JSJ3
THSLTQRRAVQGRRK	ATXN7	366	O15265
ISQSSRKRKHNQSIR	GPR87	241	Q9BY21
RRVRKRKHHNSSVVT	KAT6A	1021	Q92794
RPRKGSKTRQHQREV	FGF8	176	P55075
RGRRRSKKQNVSTSN	FRMD4B	761	Q9Y2L6
LNGRSRRAKKVASRH	ESPL1	1451	Q14674
QTRVRRGSQKKHISP	CTNNA2	926	P26232
KTSGVRNRKHLSTRQ	ATRNL1	1361	Q5VV63
PRRGQKTRRKNTSAH	FGF10	186	O15520
ERARRHKKVGRRVSQ	BMP2KL	266	Q5H9B9
AVRRSHGTQKSRKDQ	GPR68	211	Q15743
RRRTGKKSQAQAQVH	SYT5	56	O00445
SKKGALQSRAAQRHR	PLEKHN1	521	Q494U1
SQTVGRKRRHRLCST	TMEM217B	151	A0A494BZU4
QKHQGRARRKRKSVT	SPATA31D4	61	Q6ZUB0
KKKRQRRQRTHFTSQ	PITX2	81	Q99697
KSRGSNLRVHFKNTR	RPL17	16	P18621
KRSQSKHRSRSHNRS	SREK1	211	Q8WXA9
KHRSRSHNRSRSRQK	SREK1	216	Q8WXA9
SSSKRRFQKNIHRRG	SP110	436	Q9HB58
STQRHSRGTKLRKLI	PI4KB	226	Q9UBF8
RRGSQVGHKNRRKDR	RRP12	1281	Q5JTH9
DHKGRKRTRRRTASV	EIF4ENIF1	246	Q9NRA8
GRSRAKVVSQSQRSR	CLASP1	661	Q7Z460
KRNRAITARRQHLKS	TNNI2	6	P48788
RKRTQVKIRNVTSNH	PITPNM1	906	O00562
VAQTGGHKKRVRRSS	RAPGEF2	946	Q9Y4G8
QKHQGRARRKRKSVT	SPATA31D3	61	P0C874
KQKKHRRARDRSRSS	THRAP3	766	Q9Y2W1
RKSFTSKRNLVGHQR	ZNF197	936	O14709
TGSRRNRKESGLNKH	WDFY3	2286	Q8IZQ1
SRTRSTGRSQKKREH	RGS12	901	O14924
KTRQRRKIHSGSVTA	TEP1	2546	Q99973
HSRARSRTRKGILSQ	SRRM5	311	B3KS81
KRGRTFRKTRNCNRH	ZNF556	121	Q9HAH1
AAVRTRVQHGSNKRR	MRPL23	66	Q16540
ALTNTQTKGRKIRRH	ZNF292	2071	O60281
RLQRKQKNAIGSRRH	ZKSCAN4	306	Q969J2
RRRNRHSKSKVTNGV	PTDSS1	456	P48651
EKVQQENRKRHGSSR	UBR5	2471	O95071