Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine kinase activity	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 CDK11A MAPK8 CDK14 MAP4K2	2.80e-08	363	52	10	GO:0106310
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 CDK11A MAPK8 CDK14 MAP4K2	1.91e-07	446	52	10	GO:0004674
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 DDR2 CDK11A DGKQ MAPK8 CDK14 MAP4K2	2.05e-07	709	52	12	GO:0016773
GeneOntologyMolecularFunction	protein kinase activity	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 DDR2 CDK11A MAPK8 CDK14 MAP4K2	3.25e-07	600	52	11	GO:0004672
GeneOntologyMolecularFunction	MAP kinase kinase kinase kinase activity	MAP4K3 MAP4K5 MAP4K2	3.31e-07	6	52	3	GO:0008349
GeneOntologyMolecularFunction	kinase activity	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 DDR2 CDK11A DGKQ MAPK8 CDK14 MAP4K2	4.56e-07	764	52	12	GO:0016301
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 DDR2 CDK11A DGKQ PTDSS2 MAPK8 CDK14 MAP4K2	5.76e-07	938	52	13	GO:0016772
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activity	CDK15 CDK11A CDK14	6.44e-05	30	52	3	GO:0004693
GeneOntologyMolecularFunction	cyclin-dependent protein kinase activity	CDK15 CDK11A CDK14	6.44e-05	30	52	3	GO:0097472
GeneOntologyMolecularFunction	polypeptide N-acetylgalactosaminyltransferase activity	GALNT5 GALNT16	1.23e-03	20	52	2	GO:0004653
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	GALNT5 GALNT16	3.75e-03	35	52	2	GO:0008376
GeneOntologyMolecularFunction	cyclin binding	CDK15 CDK14	3.75e-03	35	52	2	GO:0030332
GeneOntologyMolecularFunction	protein tyrosine kinase activity	HIPK3 MAP2K4 DDR2	6.39e-03	145	52	3	GO:0004713
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	MAP2K4 MAPK8	6.67e-03	47	52	2	GO:0004712
GeneOntologyCellularComponent	NatC complex	NAA35 NAA30	1.89e-05	3	53	2	GO:0031417
GeneOntologyCellularComponent	N-terminal protein acetyltransferase complex	NAA35 NAA30	2.80e-04	10	53	2	GO:0031414
MousePheno	abnormal CD4-positive T cell differentiation	MAP4K3 C3AR1 MAPK8 NCKAP1L	3.92e-05	69	39	4	MP:0008076
MousePheno	abnormal b-wave shape	AGPAT3 C3AR1 TSHR MAPK8	8.90e-05	85	39	4	MP:0012035
MousePheno	abnormal b-wave amplitude	AGPAT3 C3AR1 TSHR MAPK8	8.90e-05	85	39	4	MP:0012031
MousePheno	abnormal CD4-positive helper T cell morphology	MAP4K3 C3AR1 LY9 MAPK8	1.67e-04	100	39	4	MP:0010183
MousePheno	abnormal T-helper 2 cell morphology	MAP4K3 C3AR1 LY9	1.71e-04	39	39	3	MP:0002434
MousePheno	abnormal electroretinogram waveform feature	AGPAT3 C3AR1 TSHR MAPK8	2.09e-04	106	39	4	MP:0012029
Domain	Ser/Thr_kinase_AS	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 CDK11A MAPK8 CDK14 MAP4K2	2.99e-08	357	50	10	IPR008271
Domain	S_TKc	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 CDK11A MAPK8 CDK14 MAP4K2	3.15e-08	359	50	10	SM00220
Domain	PROTEIN_KINASE_ST	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 CDK11A MAPK8 CDK14 MAP4K2	3.41e-08	362	50	10	PS00108
Domain	Prot_kinase_dom	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 DDR2 CDK11A MAPK8 CDK14 MAP4K2	5.26e-08	489	50	11	IPR000719
Domain	Pkinase	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 CDK11A MAPK8 CDK14 MAP4K2	5.51e-08	381	50	10	PF00069
Domain	PROTEIN_KINASE_DOM	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 DDR2 CDK11A MAPK8 CDK14 MAP4K2	5.71e-08	493	50	11	PS50011
Domain	MAPKKKK	MAP4K3 MAP4K5 MAP4K2	7.21e-08	4	50	3	IPR021160
Domain	Kinase-like_dom	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 DDR2 CDK11A MAPK8 CDK14 MAP4K2	1.49e-07	542	50	11	IPR011009
Domain	PROTEIN_KINASE_ATP	HIPK3 MAP2K4 VRK2 CDK15 MAP4K3 MAP4K5 CDK11A MAPK8 CDK14 MAP4K2	3.10e-07	459	50	10	PS00107
Domain	CNH	MAP4K3 MAP4K5 MAP4K2	6.44e-06	14	50	3	SM00036
Domain	CNH	MAP4K3 MAP4K5 MAP4K2	8.03e-06	15	50	3	PS50219
Domain	CNH_dom	MAP4K3 MAP4K5 MAP4K2	8.03e-06	15	50	3	IPR001180
Domain	CNH	MAP4K3 MAP4K5 MAP4K2	8.03e-06	15	50	3	PF00780
Domain	Protein_kinase_ATP_BS	HIPK3 MAP2K4 CDK15 MAP4K3 MAP4K5 CDK14 MAP4K2	6.32e-05	379	50	7	IPR017441
Domain	Ricin_B_lectin	GALNT5 GALNT16	2.03e-03	25	50	2	PF00652
Domain	RICIN	GALNT5 GALNT16	2.54e-03	28	50	2	SM00458
Domain	RICIN_B_LECTIN	GALNT5 GALNT16	2.54e-03	28	50	2	PS50231
Domain	Glyco_trans_2-like	GALNT5 GALNT16	2.91e-03	30	50	2	IPR001173
Domain	Ricin_B_lectin	GALNT5 GALNT16	2.91e-03	30	50	2	IPR000772
Domain	Glycos_transf_2	GALNT5 GALNT16	2.91e-03	30	50	2	PF00535
Pathway	BIOCARTA_MAPK_PATHWAY	MAP2K4 MAP4K3 MAP4K5 MAPK8 MAP4K2	1.52e-06	76	37	5	MM1433
Pathway	BIOCARTA_MAPK_PATHWAY	MAP2K4 MAP4K3 MAP4K5 MAPK8 MAP4K2	2.09e-06	81	37	5	M13863
Pathway	WP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS	MAP4K3 MAP4K5 MAPK8 MAP4K2	6.61e-06	47	37	4	M39829
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	MAP2K4 MAP4K3 MAP4K5 MAPK8 MAP4K2	2.29e-05	132	37	5	M39338
Pathway	BIOCARTA_STRESS_PATHWAY	MAP2K4 MAPK8 MAP4K2	3.24e-05	24	37	3	MM1515
Pathway	BIOCARTA_STRESS_PATHWAY	MAP2K4 MAPK8 MAP4K2	3.24e-05	24	37	3	M9670
Pathway	WP_INSULIN_SIGNALING	MAP2K4 MAP4K3 MAP4K5 MAPK8 MAP4K2	5.75e-05	160	37	5	M39482
Pathway	WP_INSULIN_SIGNALING	MAP2K4 MAP4K3 MAP4K5 MAPK8 MAP4K2	5.75e-05	160	37	5	MM15956
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_JNK_SIGNALING_PATHWAY	MAP2K4 MAPK8	1.86e-04	8	37	2	M47814
Pathway	PID_TNF_PATHWAY	MAP4K3 MAP4K5 MAP4K2	2.34e-04	46	37	3	M128
Pathway	REACTOME_RETROGRADE_TRANSPORT_AT_THE_TRANS_GOLGI_NETWORK	NAA35 NAA30 RIC1	2.82e-04	49	37	3	M27653
Pathway	WP_MAPK_SIGNALING	MAP2K4 MAP4K3 MAPK8 MAP4K2 PPM1B	4.29e-04	246	37	5	M39597
Pathway	REACTOME_ALK_MUTANTS_BIND_TKIS	BIRC6 PPM1B	4.35e-04	12	37	2	M42522
Pathway	KEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY	MAP2K4 MAPK8	4.35e-04	12	37	2	M47929
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY	MAP2K4 MAPK8	5.13e-04	13	37	2	M47594
Pathway	PID_TCR_JNK_PATHWAY	MAP2K4 MAPK8	5.98e-04	14	37	2	M190
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	MAP2K4 MAP4K3 MAPK8 MAP4K2 PPM1B	6.23e-04	267	37	5	M10792
Pathway	KEGG_MEDICUS_REFERENCE_TNF_JNK_SIGNALING_PATHWAY	MAP2K4 MAPK8	7.86e-04	16	37	2	M47569
Pathway	WP_MAPK_SIGNALING_PATHWAY	MAP2K4 MAP4K3 MAPK8 PPM1B	7.88e-04	160	37	4	MM15990
Pathway	BIOCARTA_MAL_PATHWAY	MAPK8 MAP4K2	9.99e-04	18	37	2	MM1482
Pathway	BIOCARTA_41BB_PATHWAY	MAP4K5 MAPK8	9.99e-04	18	37	2	M2064
Pathway	BIOCARTA_41BB_PATHWAY	MAP4K5 MAPK8	9.99e-04	18	37	2	MM1511
Pathway	KEGG_GLYCEROPHOSPHOLIPID_METABOLISM	AGPAT3 DGKQ PTDSS2	1.07e-03	77	37	3	M9131
Pathway	KEGG_MEDICUS_REFERENCE_IL1_IL1R_JNK_SIGNALING_PATHWAY	MAP2K4 MAPK8	1.11e-03	19	37	2	M47471
Pathway	BIOCARTA_MAL_PATHWAY	MAPK8 MAP4K2	1.11e-03	19	37	2	M10547
Pathway	BIOCARTA_CERAMIDE_PATHWAY	MAP2K4 MAPK8	1.36e-03	21	37	2	M19943
Pathway	WP_HIPPOYAP_SIGNALING	MAP4K3 MAP4K2	1.50e-03	22	37	2	M39821
Pathway	REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1	MAP2K4 MAPK8	1.50e-03	22	37	2	M859
Pathway	BIOCARTA_GLEEVEC_PATHWAY	MAP2K4 MAPK8	1.64e-03	23	37	2	MM1424
Pathway	REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1	MAP2K4 MAPK8	1.64e-03	23	37	2	MM15134
Pathway	BIOCARTA_GLEEVEC_PATHWAY	MAP2K4 MAPK8	1.64e-03	23	37	2	M7897
Pathway	BIOCARTA_CERAMIDE_PATHWAY	MAP2K4 MAPK8	1.64e-03	23	37	2	MM1367
Pathway	WP_TNFALPHA_SIGNALING	MAP2K4 MAPK8 MAP4K2	1.78e-03	92	37	3	M39662
Pathway	BIOCARTA_TOLL_PATHWAY	MAP2K4 MAPK8	1.78e-03	24	37	2	MM1518
Pathway	REACTOME_SIGNALING_BY_ALK_IN_CANCER	MAPK8 BIRC6 PPM1B	1.84e-03	93	37	3	M42521
Pathway	REACTOME_INTRA_GOLGI_AND_RETROGRADE_GOLGI_TO_ER_TRAFFIC	NAA35 AGPAT3 NAA30 RIC1	1.90e-03	203	37	4	M27654
Pathway	WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE	MAPK8 FBN3	1.94e-03	25	37	2	M39713
Pathway	BIOCARTA_TOLL_PATHWAY	MAP2K4 MAPK8	1.94e-03	25	37	2	M984
Pathway	BIOCARTA_AT1R_PATHWAY	MAP2K4 MAPK8	2.09e-03	26	37	2	MM1346
Pathway	BIOCARTA_PYK2_PATHWAY	MAP2K4 MAPK8	2.09e-03	26	37	2	MM1431
Pathway	KEGG_MEDICUS_REFERENCE_TLR2_4_MAPK_SIGNALING_PATHWAY	MAP2K4 MAPK8	2.09e-03	26	37	2	M47565
Pathway	BIOCARTA_AT1R_PATHWAY	MAP2K4 MAPK8	2.26e-03	27	37	2	M14899
Pathway	BIOCARTA_PYK2_PATHWAY	MAP2K4 MAPK8	2.26e-03	27	37	2	M7739
Pathway	BIOCARTA_EGF_PATHWAY	MAP2K4 MAPK8	2.26e-03	27	37	2	M1909
Pathway	BIOCARTA_TNFR1_PATHWAY	MAP2K4 MAPK8	2.43e-03	28	37	2	MM1516
Pathway	PID_TRAIL_PATHWAY	MAP2K4 MAPK8	2.43e-03	28	37	2	M79
Pathway	BIOCARTA_EGF_PATHWAY	MAP2K4 MAPK8	2.43e-03	28	37	2	MM1386
Pathway	BIOCARTA_FAS_PATHWAY	MAP2K4 MAPK8	2.43e-03	28	37	2	MM1396
Pathway	BIOCARTA_PDGF_PATHWAY	MAP2K4 MAPK8	2.43e-03	28	37	2	M2529
Pathway	BIOCARTA_PDGF_PATHWAY	MAP2K4 MAPK8	2.60e-03	29	37	2	MM1452
Pathway	WP_PDGFRBETA_PATHWAY	MAP2K4 MAPK8	2.60e-03	29	37	2	M39616
Pathway	BIOCARTA_TNFR1_PATHWAY	MAP2K4 MAPK8	2.60e-03	29	37	2	M3618
Pathway	KEGG_O_GLYCAN_BIOSYNTHESIS	GALNT5 GALNT16	2.78e-03	30	37	2	M6929
Pathway	PID_EPHRINB_REV_PATHWAY	MAP2K4 MAPK8	2.78e-03	30	37	2	M257
Pathway	BIOCARTA_FAS_PATHWAY	MAP2K4 MAPK8	2.78e-03	30	37	2	M9503
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS17 GALNT5 GALNT16	2.89e-03	109	37	3	MM15164
Pathway	PID_NEPHRIN_NEPH1_PATHWAY	MAP2K4 MAPK8	2.97e-03	31	37	2	M193
Pathway	PID_CD40_PATHWAY	MAP2K4 MAPK8	2.97e-03	31	37	2	M45
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS17 GALNT5 GALNT16	3.04e-03	111	37	3	M27416
Pathway	SIG_CD40PATHWAYMAP	MAP2K4 MAPK8	3.57e-03	34	37	2	M12705
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING	MAP2K4 MAPK8	3.99e-03	36	37	2	M39908
Pathway	WP_FAS_PATHWAY_AND_STRESS_INDUCTION_OF_HSP_REGULATION	MAP2K4 MAPK8	3.99e-03	36	37	2	MM15967
Pathway	REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE	MAP2K4 MAPK8	4.21e-03	37	37	2	MM14899
Pathway	BIOCARTA_FCER1_PATHWAY	MAP2K4 MAPK8	4.67e-03	39	37	2	M1908
Pathway	BIOCARTA_FCER1_PATHWAY	MAP2K4 MAPK8	4.67e-03	39	37	2	MM1397
Pathway	WP_OXIDATIVE_DAMAGE_RESPONSE	MAP2K4 C3AR1	4.91e-03	40	37	2	M39340
Pathway	WP_PDGF_PATHWAY	MAP2K4 MAPK8	4.91e-03	40	37	2	M39555
Pathway	BIOCARTA_TCR_PATHWAY	MAP2K4 MAPK8	5.40e-03	42	37	2	MM1504
Pathway	WP_OXIDATIVE_DAMAGE_RESPONSE	MAP2K4 C3AR1	5.40e-03	42	37	2	MM15945
Pathway	WP_FAS_LIGAND_PATHWAY_AND_STRESS_INDUCTION_OF_HEAT_SHOCK_PROTEINS	MAP2K4 MAPK8	5.92e-03	44	37	2	M39673
Pathway	PID_CERAMIDE_PATHWAY	MAP2K4 MAPK8	5.92e-03	44	37	2	M144
Pathway	BIOCARTA_TCR_PATHWAY	MAP2K4 MAPK8	5.92e-03	44	37	2	M19784
Pubmed	Cyclin-dependent kinases: a family portrait.	CDK15 CDK11A CDK14	7.28e-07	12	53	3	19884882
Pubmed	Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity.	MAP2K4 MAPK8	2.28e-06	2	53	2	9096336
Pubmed	JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells.	HIPK3 MAPK8	2.28e-06	2	53	2	14766760
Pubmed	Regulation of JNK by MKK-7 in fibroblast-like synoviocytes.	MAP2K4 MAPK8	6.83e-06	3	53	2	16802349
Pubmed	Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation.	MAP2K4 MAPK8	6.83e-06	3	53	2	11707464
Pubmed	Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase.	MAP2K4 MAPK8	6.83e-06	3	53	2	9661668
Pubmed	MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases.	MAP2K4 MAPK8	6.83e-06	3	53	2	9405400
Pubmed	Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins.	MAP2K4 MAPK8	6.83e-06	3	53	2	17187786
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	HIPK3 MAP2K4 YIF1B MAP4K3 MAP4K5 DDR2 CDK11A MAPK8 CDK14	8.72e-06	910	53	9	36736316
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	MAP4K3 VPS13C AGPAT3 GALNT5 BIRC6 ZDHHC3 MAP4K2 WDR72	1.25e-05	719	53	8	35337019
Pubmed	Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body Insulin sensitivity.	MAP2K4 MAPK8	1.36e-05	4	53	2	19351724
Pubmed	Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38.	MAP2K4 MAP4K2	1.36e-05	4	53	2	9712898
Pubmed	Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK.	MAP2K4 MAPK8	1.36e-05	4	53	2	13130464
Pubmed	The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.	MAP2K4 MAPK8	1.36e-05	4	53	2	22114267
Pubmed	Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5.	MAP2K4 MAPK8	1.36e-05	4	53	2	17541429
Pubmed	HER2-driven breast cancer suppression by the JNK signaling pathway.	MAP2K4 MAPK8	1.36e-05	4	53	2	36656864
Pubmed	A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization.	MAP2K4 MAPK8	1.36e-05	4	53	2	22031940
Pubmed	Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.	MAP2K4 MAPK8	1.36e-05	4	53	2	15731347
Pubmed	Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines.	SLC11A2 MAPK8	1.36e-05	4	53	2	28672025
Pubmed	Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases.	MAP2K4 MAPK8	1.36e-05	4	53	2	18713996
Pubmed	Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation.	MAP2K4 MAPK8	1.36e-05	4	53	2	20156194
Pubmed	Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.	MAP2K4 MAPK8	2.27e-05	5	53	2	7839144
Pubmed	Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.	MAP2K4 MAPK8	2.27e-05	5	53	2	10713157
Pubmed	A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity.	MAP2K4 MAPK8	2.27e-05	5	53	2	25043814
Pubmed	ROCK activity affects IL-1-induced signaling possibly through MKK4 and p38 MAPK in Caco-2 cells.	MAP2K4 MAPK8	2.27e-05	5	53	2	27173611
Pubmed	N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.	NAA35 NAA30	2.27e-05	5	53	2	37891180
Pubmed	Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK.	MAP2K4 MAPK8	2.27e-05	5	53	2	28753655
Pubmed	Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice.	MAP2K4 MAPK8	2.27e-05	5	53	2	34502275
Pubmed	Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.	MAP2K4 MAPK8	2.27e-05	5	53	2	9207092
Pubmed	Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon).	MAP2K4 PPM1B	3.40e-05	6	53	2	12556533
Pubmed	Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation.	MAP2K4 MAPK8	3.40e-05	6	53	2	12228228
Pubmed	Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop.	MAP2K4 MAPK8	3.40e-05	6	53	2	15998799
Pubmed	Stress-activated kinase pathway alteration is a frequent event in bladder cancer.	MAP2K4 MAPK8	3.40e-05	6	53	2	22154358
Pubmed	Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release.	MAPK8 MAP4K2	3.40e-05	6	53	2	17584736
Pubmed	Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1.	VRK2 MAPK8	3.40e-05	6	53	2	17709393
Pubmed	SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification.	MAP2K4 MAPK8	4.76e-05	7	53	2	16142216
Pubmed	Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.	NAA35 NAA30	4.76e-05	7	53	2	19398576
Pubmed	JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.	MAP2K4 MAPK8	4.76e-05	7	53	2	22753496
Pubmed	Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.	MAP2K4 MAPK8	4.76e-05	7	53	2	12189133
Pubmed	Negative regulation of MEKK1-induced signaling by glutathione S-transferase Mu.	MAP2K4 MAPK8	4.76e-05	7	53	2	15299005
Pubmed	Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.	MAP2K4 MAPK8	4.76e-05	7	53	2	11062067
Pubmed	A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.	MAP2K4 MAPK8	4.76e-05	7	53	2	17681137
Pubmed	Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity.	MAP2K4 MAPK8	6.34e-05	8	53	2	12659851
Pubmed	JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.	MAP2K4 MAPK8	6.34e-05	8	53	2	9808624
Pubmed	JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors.	MAP2K4 MAPK8	6.34e-05	8	53	2	12391307
Pubmed	Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.	VRK2 MAPK8	6.34e-05	8	53	2	18286207
Pubmed	FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury.	MAP2K4 FKBPL	6.34e-05	8	53	2	35101451
Pubmed	Subdomain VIII is a specificity-determining region in MEKK1.	MAP2K4 MAPK8	6.34e-05	8	53	2	14500727
Pubmed	Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells.	MAP2K4 MAPK8	6.34e-05	8	53	2	15218018
Pubmed	Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.	MAP2K4 MAPK8	8.15e-05	9	53	2	11279118
Pubmed	ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.	MAP2K4 MAPK8	8.15e-05	9	53	2	19270716
Pubmed	JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.	MAP2K4 MAPK8	8.15e-05	9	53	2	10523642
Pubmed	Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.	MAP2K4 MAPK8	8.15e-05	9	53	2	14504284
Pubmed	Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK.	MAP2K4 MAPK8	8.15e-05	9	53	2	26947074
Pubmed	SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation.	MAP2K4 MAPK8	8.15e-05	9	53	2	32427938
Pubmed	SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.	MAP2K4 MAPK8	1.02e-04	10	53	2	12376107
Pubmed	ADAP regulates cell cycle progression of T cells via control of cyclin E and Cdk2 expression through two distinct CARMA1-dependent signaling pathways.	MAP2K4 MAPK8	1.02e-04	10	53	2	22411628
Pubmed	A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.	MAP2K4 MAPK8	1.02e-04	10	53	2	12788955
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	HIPK3 MAP4K3 WDR83 CDK11A GALNT5 GALNT16 PPM1B	1.16e-04	730	53	7	34857952
Pubmed	Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.	MAP2K4 MAPK8	1.24e-04	11	53	2	9162092
Pubmed	Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases.	MAP2K4 MAPK8	1.24e-04	11	53	2	16533805
Pubmed	Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.	MAP2K4 MAPK8	1.49e-04	12	53	2	28641113
Pubmed	A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates.	NAA35 NAA30	1.49e-04	12	53	2	19660095
Pubmed	A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity.	MAP2K4 MAPK8	1.76e-04	13	53	2	17526490
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	MAP4K5 MAPK8 MAP4K2	2.34e-04	78	53	3	17192257
Pubmed	Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.	MAP2K4 MAPK8	2.36e-04	15	53	2	18635759
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	CDK15 DDR2 CDK11A CDK14 MAP4K2	2.57e-04	372	53	5	22939624
Pubmed	Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions.	MAP2K4 PPM1B	2.70e-04	16	53	2	19294699
Pubmed	Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.	MAP2K4 MAPK8	3.05e-04	17	53	2	19753101
Pubmed	Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions.	MAP2K4 MAPK8	3.05e-04	17	53	2	32659913
Pubmed	Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.	MAP2K4 MAPK8	3.43e-04	18	53	2	22090513
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	IBTK MAP4K3 AGPAT3 PTRH2	3.46e-04	218	53	4	33378226
Pubmed	Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).	MAP2K4 MAPK8	4.25e-04	20	53	2	12897243
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	MON2 NAA35 YIF1B PTRH2 NAA30 PTDSS2 MAPK8	5.08e-04	931	53	7	27432908
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT5 GALNT16	6.16e-04	24	53	2	31740596
Pubmed	Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.	GALNT5 GALNT16	6.16e-04	24	53	2	31882545
Pubmed	Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.	MAP2K4 MAPK8	7.23e-04	26	53	2	17875933
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	MON2 IBTK VRK2 VPS13C BIRC6 ZDHHC3	8.49e-04	733	53	6	34672954
Pubmed	Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.	MAP2K4 MAPK8	9.64e-04	30	53	2	17699753
Pubmed	Functional analysis of secreted and transmembrane proteins critical to mouse development.	PTDSS2 BIRC6	1.03e-03	31	53	2	11431694
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	MON2 VPS13C	1.03e-03	31	53	2	25838543
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	YIF1B AGPAT3 PTRH2 WDR83 PTDSS2 ZDHHC3 WDR72	1.09e-03	1061	53	7	33845483
Pubmed	Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.	VPS13C DGKQ	1.17e-03	33	53	2	25064009
Pubmed	Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.	AGPAT3 DDC	1.17e-03	33	53	2	16870172
Pubmed	Expression of the Bcl-2 protein BAD promotes prostate cancer growth.	MAP2K4 MAPK8	1.24e-03	34	53	2	19593445
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	YIF1B TAFA5 ZDHHC3	1.34e-03	142	53	3	11812828
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	GALNT5 GALNT16	1.39e-03	36	53	2	25615642
Interaction	MAP4K2 interactions	MAP2K4 MAP4K3 MAP4K5 NAA30 MAP4K2	3.20e-06	98	47	5	int:MAP4K2
Cytoband	1q23.3	DDR2 LY9	1.49e-03	49	53	2	1q23.3
GeneFamily	Mitogen-activated protein kinase kinase kinase kinases	MAP4K3 MAP4K5 MAP4K2	7.23e-08	5	36	3	655
GeneFamily	Cyclin dependent kinases	CDK15 CDK11A CDK14	1.83e-05	26	36	3	496
GeneFamily	N(alpha)-acetyltransferase subunits\|GCN5 related N-acetyltransferases	NAA35 NAA30	2.51e-04	12	36	2	660
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT5 GALNT16	7.16e-04	20	36	2	433
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Striatum / BrainAtlas - Mouse McCarroll V32	GFRAL ADAMTS17 PCDHAC1 TSHR	3.09e-06	84	53	4	9417fffe0ba79f5851920258dcd0f6c09218be13
Disease	Parkinson's disease (implicated_via_orthology)	HIPK3 YIF1B VPS13C MAPK8 DDC	6.99e-06	157	50	5	DOID:14330 (implicated_via_orthology)
Disease	glucose tolerance test	MAP4K5 VPS13C MAP4K2	1.30e-05	27	50	3	EFO_0004307
Disease	Squamous cell carcinoma of lung	MAP2K4 MAP4K3 DDR2	2.19e-05	32	50	3	C0149782
Disease	fasting blood glucose measurement, glucose tolerance test, fasting blood insulin measurement	MAP4K5 VPS13C	2.80e-05	5	50	2	EFO_0004307, EFO_0004465, EFO_0004466
Disease	triacylglycerol 52:4 measurement	MAP4K5 AGPAT3 GALNT16	3.14e-05	36	50	3	EFO_0010416
Disease	ciliopathy (implicated_via_orthology)	MAP4K3 MAP4K5 MAP4K2	4.33e-05	40	50	3	DOID:0060340 (implicated_via_orthology)
Disease	GM3 ganglioside measurement	CDK14 FBN3	1.53e-04	11	50	2	EFO_0021451
Disease	urolithiasis	MAP2K4 MAP4K5 WDR72	1.69e-04	63	50	3	MONDO_0024647
Disease	SLAM family member 7 measurement	DDR2 LY9	3.77e-04	17	50	2	EFO_0008287
Disease	triacylglycerol 54:6 measurement	MAP4K5 AGPAT3	6.36e-04	22	50	2	EFO_0010424
Disease	smoking status measurement	MON2 VRK2 PXDNL DLEC1 BIRC6 TMEM71 GALNT16 WDR72	6.88e-04	1160	50	8	EFO_0006527
Disease	BMI-adjusted fasting blood glucose measurement	MAP4K5 MAP4K2	6.96e-04	23	50	2	EFO_0008036
Disease	opioid dependence	OR1J1 DLEC1 MAPK8 WDR72	6.99e-04	237	50	4	EFO_0005611
Disease	pallidum volume	BIRC6 WDR72	8.23e-04	25	50	2	EFO_0006933
Disease	fasting blood glucose measurement, HOMA-B, fasting blood insulin measurement	MAP4K5 MAP4K2	8.23e-04	25	50	2	EFO_0004465, EFO_0004466, EFO_0004469
Disease	macular telangiectasia type 2	MAP4K5 FBN3	8.91e-04	26	50	2	EFO_1002009
Disease	lissencephaly (implicated_via_orthology)	CDK15 CDK14	9.61e-04	27	50	2	DOID:0050453 (implicated_via_orthology)
Disease	docosapentaenoic acid measurement	MAP4K5 AGPAT3	9.61e-04	27	50	2	EFO_0006809
Disease	chloride measurement	MAP4K5 WDR72	1.11e-03	29	50	2	EFO_0009284
Disease	triacylglycerol 54:5 measurement	MAP4K5 AGPAT3	1.35e-03	32	50	2	EFO_0010423
Disease	nephrolithiasis	MAP4K5 WDR72	1.44e-03	33	50	2	EFO_0004253
Disease	hyperthyroidism	TSHR TMEM71	1.62e-03	35	50	2	EFO_0009189
Disease	creatinine measurement, chronic kidney disease	MAP4K5 WDR72	1.62e-03	35	50	2	EFO_0003884, EFO_0004518
Disease	triacylglycerol 52:5 measurement	MAP4K5 AGPAT3	1.62e-03	35	50	2	EFO_0010417
Disease	alcohol use disorder measurement, longitudinal alcohol consumption measurement	VRK2 MAP4K5	1.80e-03	37	50	2	EFO_0007645, EFO_0009458
Disease	serum IgG glycosylation measurement	MON2 VPS13C ADAMTS17 FKBPL TSHR	1.89e-03	523	50	5	EFO_0005193
Disease	Malignant neoplasm of breast	MAP2K4 GFRAL FKBPL DLEC1 GALNT5 SMOX GALNT16	2.11e-03	1074	50	7	C0006142
Disease	cognitive impairment measurement	PXDNL FBN3	2.54e-03	44	50	2	EFO_0007998
Disease	triacylglycerol 54:4 measurement	MAP4K5 AGPAT3	2.78e-03	46	50	2	EFO_0010422
Disease	neuritic plaque measurement	PXDNL ADAMTS17 TAFA5 CDK14	2.89e-03	349	50	4	EFO_0006798

Protein segments in the cluster

Peptide	Gene	Start	Entry
GVSEWLVLRDGCMHC	BIRC6	51	Q9NR09
IWGLAGFLCDVCNFM	DGKQ	81	P52824
TCLDMWGVGCIFVEM	CDK14	311	O94921
ADMLCGAIGCIGFSW	DDC	91	P20711
MDVCCCSIGAVWGVE	FBN3	936	Q75N90
VGMACSICGCIWVVA	C3AR1	136	Q16581
SICGCIWVVAFVMCI	C3AR1	141	Q16581
EHLMCAGLWCLVEGD	ADAMTS17	491	Q8TE56
FRVWMCGGSLEIVPC	GALNT16	326	Q8N428
GALFREGDCWICMEL	MAP2K4	166	P45985
FMEAGCLDWCIVIGL	RIC1	1271	Q4ADV7
LWICMEFCGGGSLQE	MAP4K2	86	Q12851
LWICMEFCGGGSLQD	MAP4K3	86	Q8IVH8
MRFLTGTCLDEWIIC	NCBP2L	96	A6PVI3
VCMRVELYGCVWLDG	DDR2	176	Q16832
ICILAMDGAGRVFCW	IBTK	406	Q9P2D0
QLWFEKAEGMFCVGL	CFAP65	221	Q6ZU64
VDLWSVGCIMGEMVC	MAPK8	206	P45983
LCCVLVAASWMGGFV	OR4Q2	141	P0C623
MERWIIIGFLLCHGC	NCKAP1L	256	P55160
GWQCLIALGMSFLDC	SLC11A2	526	P49281
EEMVNACWCGLLAAL	MON2	551	Q7Z3U7
CVMLVAGSWVIACAC	OR1J1	141	Q8NGS3
CQLLVSACWVLGMVD	OR2T34	146	Q8NGX1
CQLLVSACWVLGMVD	OR2T3	146	Q8NH03
FCEAIDMWSLGCVIA	HIPK3	376	Q9H422
MVGCGVAVLCLWVSC	PCDHAC1	1	Q9H158
ALVCDCDLMWLGELL	PXDNL	181	A1KZ92
WGELIEKCLESMCQG	FKBPL	156	Q9UIM3
LDIWGAGCIFIEMFQ	CDK15	281	Q96Q40
KGMWSCLEVAEACVG	GFRAL	126	Q6UXV0
VWMCGGEIEIIPCSR	GALNT5	706	Q7Z7M9
AVDMWSVGCIFGELL	CDK11A	606	Q9UQ88
WIGLFLMVCLLCVGI	LY9	456	Q9HBG7
LCIDITGCANMWGEY	DLEC1	1201	Q9Y238
WICMEYCGGGSLQDI	MAP4K5	91	Q9Y4K4
WCDMLPCLEGEGCDL	TAFA5	96	Q7Z5A7
AVCLIISACARWFMG	TMEM71	241	Q6P5X7
WIMDVLVCNGLGIYC	PTDSS2	246	Q9BVG9
EFIILACDGIWDVMS	PPM1B	236	O75688
GLFCLMFLCAAEWVT	CNIH2	76	Q6PI25
VGVACGMCLGWSLRV	PTRH2	21	Q9Y3E5
VLGWCCVAIFVFMIR	YIF1B	251	Q5BJH7
MWFIRDGCGIACAIV	ZDHHC3	36	Q9NYG2
DFLCGWTMCERFGVL	AGPAT3	101	Q9NRZ7
IGIMDTCFCCLITWL	NAA35	106	Q5VZE5
GWICGEEALVMEKCD	SMOX	426	Q9NWM0
MTGEGWLLCCGEYQD	WDR72	121	Q3MJ13
ILGLMCVDWQCPFED	VPS13C	3661	Q709C8
CLLTAMGGSVQCWRE	WDR83	291	Q9BRX9
LCWMALCLLGAELSE	TRBV11-1	6	A0A0K0K1C0
SDVEILGYCMLRWLC	VRK2	231	Q86Y07
IMVGGWVCCFLLALL	TSHR	541	P16473
WPQLCFLAMVGEECV	NAA30	251	Q147X3