Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

ABCC4 MFSD12 SLC22A1 SLC22A2 ABCC2

1.17e-0561975GO:1901682
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

ABCC4 SLC22A1 SLC22A2 ABCC2

2.17e-0534974GO:0042910
GeneOntologyMolecularFunctionprostaglandin transmembrane transporter activity

ABCC4 SLC22A1 SLC22A2

3.89e-0514973GO:0015132
GeneOntologyMolecularFunctionicosanoid transmembrane transporter activity

ABCC4 SLC22A1 SLC22A2

4.85e-0515973GO:0071714
GeneOntologyMolecularFunctionNuRD complex binding

PWWP2A PWWP2B

6.98e-053972GO:0120325
GeneOntologyMolecularFunctionacetate ester transmembrane transporter activity

SLC22A1 SLC22A2

1.39e-044972GO:1901375
GeneOntologyMolecularFunctionputrescine transmembrane transporter activity

SLC22A1 SLC22A2

1.39e-044972GO:0015489
GeneOntologyMolecularFunctionacetylcholine transmembrane transporter activity

SLC22A1 SLC22A2

1.39e-044972GO:0005277
GeneOntologyMolecularFunctionATP-dependent activity

TMEM30B ABCC4 DYNC2H1 CHD8 ACSS2 BCS1L HELB NAE1 CHD5 NAV1 ABCC2

1.93e-046149711GO:0140657
GeneOntologyMolecularFunctionspermidine transmembrane transporter activity

SLC22A1 SLC22A2

2.31e-045972GO:0015606
GeneOntologyMolecularFunctionendopeptidase activity

DPP4 PRSS38 PIDD1 HM13 CAPN7 KLK9 ATG4C PLAT ECEL1

2.46e-04430979GO:0004175
GeneOntologyMolecularFunctionpeptidase activity

DPP4 PRSS38 PIDD1 ERMP1 HM13 MINDY2 CAPN7 KLK9 ATG4C PLAT ECEL1

3.31e-046549711GO:0008233
GeneOntologyMolecularFunctionlipid transporter activity

TMEM30B ABCC4 SLC22A1 SLC22A2 ANO7 ANO3

3.90e-04196976GO:0005319
GeneOntologyMolecularFunctionthiamine transmembrane transporter activity

SLC22A1 SLC22A2

4.83e-047972GO:0015234
GeneOntologyMolecularFunctionABC-type glutathione S-conjugate transporter activity

ABCC4 ABCC2

6.42e-048972GO:0015431
GeneOntologyMolecularFunctionpyrimidine nucleoside transmembrane transporter activity

SLC22A1 SLC22A2

6.42e-048972GO:0015214
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

MFSD12 SLC3A2 SLC22A1 SLC22A2

7.17e-0483974GO:0015101
GeneOntologyMolecularFunctionnucleoside transmembrane transporter activity

SLC22A1 SLC22A2

1.02e-0310972GO:0005337
GeneOntologyMolecularFunctionATPase-coupled inorganic anion transmembrane transporter activity

ABCC4 ABCC2

1.02e-0310972GO:0043225
GeneOntologyMolecularFunctionpolyamine transmembrane transporter activity

SLC22A1 SLC22A2

1.25e-0311972GO:0015203
GeneOntologyMolecularFunctionUDP-xylosyltransferase activity

LARGE2 RXYLT1

1.25e-0311972GO:0035252
GeneOntologyMolecularFunctionxylosyltransferase activity

LARGE2 RXYLT1

1.25e-0311972GO:0042285
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCC4 DYNC2H1 CHD8 BCS1L HELB CHD5 NAV1 ABCC2

1.38e-03441978GO:0016887
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

ABCC4 SLC22A1 ANO7 ABCC2 ANO3

1.48e-03171975GO:0015103
GeneOntologyMolecularFunctionstore-operated calcium channel activity

TRPC5 STIM1

1.49e-0312972GO:0015279
GeneOntologyMolecularFunctionmonoamine transmembrane transporter activity

SLC22A1 SLC22A2

1.49e-0312972GO:0008504
GeneOntologyMolecularFunctiontoxin transmembrane transporter activity

SLC22A1 SLC22A2

1.49e-0312972GO:0019534
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

TMEM30B ANO7 ANO3

1.95e-0351973GO:0140303
GeneOntologyMolecularFunctionazole transmembrane transporter activity

SLC22A1 SLC22A2

2.05e-0314972GO:1901474
GeneOntologyMolecularFunctionquaternary ammonium group transmembrane transporter activity

SLC22A1 SLC22A2

2.35e-0315972GO:0015651
GeneOntologyMolecularFunctionABC-type xenobiotic transporter activity

ABCC4 ABCC2

2.35e-0315972GO:0008559
GeneOntologyMolecularFunctionpentosyltransferase activity

LARGE2 RXYLT1 PARP12

2.56e-0356973GO:0016763
GeneOntologyMolecularFunctionefflux transmembrane transporter activity

ABCC4 SLC22A2

2.68e-0316972GO:0015562
GeneOntologyMolecularFunctionnucleobase-containing compound transmembrane transporter activity

ABCC4 SLC22A1 SLC22A2

2.97e-0359973GO:0015932
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

ABCC4 MFSD12 SLC3A2 SLC22A1 SLC22A2 ABCC2

3.07e-03293976GO:0008514
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase regulator activity

PRKD1 RUBCN

3.40e-0318972GO:0035014
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

ABCC4 MFSD12 SLC3A2 SLC22A2 ABCC2

3.40e-03207975GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

ABCC4 MFSD12 SLC3A2 SLC22A2 ABCC2

3.47e-03208975GO:0005342
GeneOntologyMolecularFunctiontransporter activity

TMEM30B ABCC4 TRPC5 BCS1L MFSD12 SLC3A2 STIM1 KCNH6 SLC22A1 SLC22A2 ANO7 LRRC8B ABCC2 ANO3

3.70e-0312899714GO:0005215
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO7 ANO3

4.19e-0320972GO:0141147
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO7 ANO3

4.19e-0320972GO:0005229
GeneOntologyMolecularFunctiontransmembrane transporter activity

ABCC4 TRPC5 BCS1L MFSD12 SLC3A2 STIM1 KCNH6 SLC22A1 SLC22A2 ANO7 LRRC8B ABCC2 ANO3

4.59e-0311809713GO:0022857
GeneOntologyMolecularFunctionneurotransmitter transmembrane transporter activity

SLC22A1 SLC22A2

4.62e-0321972GO:0005326
GeneOntologyMolecularFunctionlipid transmembrane transporter activity

ABCC4 SLC22A1 SLC22A2

5.41e-0373973GO:0170055
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO7 ANO3

5.53e-0323972GO:0017128
GeneOntologyMolecularFunctionphospholipid transporter activity

TMEM30B ANO7 ANO3

5.61e-0374973GO:0005548
GeneOntologyBiologicalProcessxenobiotic transport across blood-brain barrier

SLC22A1 SLC22A2 ABCC2

1.93e-066963GO:1990962
GeneOntologyBiologicalProcesssulfur compound transport

ABCC4 MFSD12 SLC3A2 SLC22A1 SLC22A2

1.30e-0565965GO:0072348
GeneOntologyBiologicalProcessprostaglandin transport

ABCC4 SLC22A1 SLC22A2 ABCC2

1.84e-0534964GO:0015732
GeneOntologyBiologicalProcessicosanoid transport

ABCC4 CYP4A11 SLC22A1 SLC22A2 ABCC2

2.30e-0573965GO:0071715
GeneOntologyBiologicalProcesspurine-containing compound transmembrane transport

ABCC4 SLC22A1 SLC22A2 LRRC8B

3.54e-0540964GO:0072530
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

TCAF2 ABCC4 ANO7 LRRC8B ABCC2 ANO3

8.08e-05153966GO:0098656
GeneOntologyBiologicalProcessorganophosphate ester transport

TMEM30B ABCC4 TRPC5 ANO7 LRRC8B ANO3

1.11e-04162966GO:0015748
GeneOntologyBiologicalProcesslipid transport

TMEM30B ABCC4 CYP4A11 TRPC5 GDF9 SLC22A1 SLC22A2 ANO7 ABCC2 ANO3

1.23e-045069610GO:0006869
GeneOntologyBiologicalProcessphospholipid translocation

TMEM30B TRPC5 ANO7 ANO3

1.25e-0455964GO:0045332
GeneOntologyBiologicalProcessspermidine transmembrane transport

SLC22A1 SLC22A2

1.28e-044962GO:1903711
GeneOntologyBiologicalProcessputrescine transport

SLC22A1 SLC22A2

1.28e-044962GO:0015847
GeneOntologyBiologicalProcesslipid translocation

TMEM30B TRPC5 ANO7 ANO3

1.76e-0460964GO:0034204
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

TCAF2 ABCC4 ERO1A TRPC5 SLC3A2 STIM1 KCNH6 PIK3C2A SLC22A1 STEAP3 ANO7 PRKD1 LRRC8B ABCC2 ANO3

1.90e-0411159615GO:0034220
GeneOntologyBiologicalProcesscalcium activated phospholipid scrambling

ANO7 ANO3

2.12e-045962GO:0061588
GeneOntologyBiologicalProcesscalcium activated phosphatidylcholine scrambling

ANO7 ANO3

2.12e-045962GO:0061590
GeneOntologyBiologicalProcesscalcium activated galactosylceramide scrambling

ANO7 ANO3

2.12e-045962GO:0061591
GeneOntologyBiologicalProcessmonoatomic anion transport

TCAF2 ABCC4 ANO7 LRRC8B ABCC2 ANO3

2.15e-04183966GO:0006820
GeneOntologyBiologicalProcessxenobiotic transport

ABCC4 SLC22A1 SLC22A2 ABCC2

2.26e-0464964GO:0042908
GeneOntologyBiologicalProcessplasma membrane phospholipid scrambling

TRPC5 ANO7 ANO3

2.35e-0426963GO:0017121
GeneOntologyBiologicalProcessregulation of membrane lipid distribution

TMEM30B TRPC5 ANO7 ANO3

2.40e-0465964GO:0097035
GeneOntologyBiologicalProcesslipid localization

TMEM30B ABCC4 CYP4A11 TRPC5 GDF9 SLC22A1 SLC22A2 ANO7 ABCC2 ANO3

3.00e-045659610GO:0010876
GeneOntologyBiologicalProcessspermidine transport

SLC22A1 SLC22A2

3.18e-046962GO:0015848
GeneOntologyBiologicalProcessprotein processing

DPP4 DYNC2H1 PIDD1 HM13 ATG4C PLAT ECEL1

3.73e-04285967GO:0016485
GeneOntologyBiologicalProcessfatty acid transport

ABCC4 CYP4A11 SLC22A1 SLC22A2 ABCC2

3.82e-04132965GO:0015908
GeneOntologyBiologicalProcessleukotriene transport

ABCC4 ABCC2

4.43e-047962GO:0071716
GeneOntologyBiologicalProcessthiamine transmembrane transport

SLC22A1 SLC22A2

4.43e-047962GO:0071934
GeneOntologyBiologicalProcessmonoatomic ion transport

TCAF2 ABCC4 ERO1A TRPC5 SLC3A2 STIM1 KCNH6 PIK3C2A SLC22A1 SLC22A2 STEAP3 ANO7 PRKD1 LRRC8B ABCC2 ANO3

5.75e-0413749616GO:0006811
GeneOntologyBiologicalProcessthiamine transport

SLC22A1 SLC22A2

5.89e-048962GO:0015888
GeneOntologyBiologicalProcessprotein maturation

DPP4 CLGN DYNC2H1 ERO1A UGGT1 PIDD1 HM13 ATG4C PLAT ECEL1

6.12e-046199610GO:0051604
GeneOntologyBiologicalProcesscarboxylic acid transport

ABCC4 CYP4A11 MFSD12 SLC3A2 SLC22A1 SLC22A2 LRRC8B ABCC2

6.57e-04410968GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

ABCC4 CYP4A11 MFSD12 SLC3A2 SLC22A1 SLC22A2 LRRC8B ABCC2

6.79e-04412968GO:0015849
GeneOntologyCellularComponentapical part of cell

CHL1 DPP4 ABCC4 DYNC2H1 CYP4A11 SLC3A2 VANGL2 CLDN24 SLC22A1 SLC22A2 PLAT ABCC2 MUC4

3.92e-065929813GO:0045177
GeneOntologyCellularComponentapical plasma membrane

DPP4 ABCC4 CYP4A11 SLC3A2 VANGL2 CLDN24 SLC22A1 SLC22A2 ABCC2 MUC4

9.63e-054879810GO:0016324
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

LARGE2 ABCC4 CLGN ERO1A UGGT1 ERMP1 RXYLT1 HM13 SLC3A2 STIM1 NPTN CELSR2 NAE1 ECEL1 SELENOI HECTD1

3.76e-0712011011635696571
Pubmed

Properties and regulation of organic cation transport in freshly isolated human proximal tubules.

SLC22A1 SLC22A2

8.35e-062101211447227
Pubmed

Characterization of human organic cation transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-mediated transport of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule survivin suppressant.

SLC22A1 SLC22A2

8.35e-062101219833842
Pubmed

Organic cation transporters OCT1 and OCT2 determine the accumulation of lamivudine in CD4 cells of HIV-infected patients.

SLC22A1 SLC22A2

8.35e-062101222875535
Pubmed

Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.

ABCC4 ABCC2

8.35e-062101217083032
Pubmed

Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules.

SLC22A1 SLC22A2

8.35e-062101224233562
Pubmed

Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression.

DPP4 PEMT

8.35e-062101236472923
Pubmed

Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin.

SLC22A1 SLC22A2

8.35e-062101237511245
Pubmed

Functional characterization of mouse cation transporter mOCT2 compared with mOCT1.

SLC22A1 SLC22A2

8.35e-062101212176030
Pubmed

Dok1 and SHIP act as negative regulators of v-Abl-induced pre-B cell transformation, proliferation and Ras/Erk activation.

DOK1 INPP5D

8.35e-062101215655368
Pubmed

Cloning and characterization of two human polyspecific organic cation transporters.

SLC22A1 SLC22A2

8.35e-06210129260930
Pubmed

Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.

SLC22A1 SLC22A2

8.35e-062101220110413
Pubmed

Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine.

SLC22A1 SLC22A2

8.35e-062101229236753
Pubmed

Influence of ABCC2 and ABCC4 polymorphisms on tenofovir plasma concentrations in Thai HIV-infected patients.

ABCC4 ABCC2

8.35e-062101225801567
Pubmed

New mechanistic explanation for the localization of ulcers in the rat duodenum: role of iron and selective uptake of cysteamine.

SLC22A1 SLC22A2

8.35e-062101222684023
Pubmed

Major contribution of tubular secretion to creatinine clearance in mice.

SLC22A1 SLC22A2

8.35e-062101220032962
Pubmed

Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.

SLC22A1 SLC22A2

8.35e-062101234902340
Pubmed

Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.

SLC22A1 SLC22A2

8.35e-062101214560032
Pubmed

Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2-/- Mice.

SLC22A1 SLC22A2

8.35e-062101233658943
Pubmed

Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin.

SLC22A1 SLC22A2

8.35e-062101217111267
Pubmed

Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions.

SLC22A1 SLC22A2

8.35e-062101225848011
Pubmed

Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development.

DOK1 INPP5D

8.35e-062101216547230
Pubmed

GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines.

GDF3 GDF9

8.35e-06210128429021
Pubmed

Identification and functional characterization of genetic variants of human organic cation transporters in a Korean population.

SLC22A1 SLC22A2

8.35e-062101217220237
Pubmed

The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26.

SLC22A1 SLC22A2

8.35e-06210129605850
Pubmed

Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline, a new therapy for smoking cessation: an in vitro-in vivo study.

SLC22A1 SLC22A2

8.35e-062101217971819
Pubmed

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse.

SLC22A1 SLC22A2

8.35e-062101216608531
Pubmed

Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.

ABCC4 ABCC2

8.35e-062101223222202
Pubmed

The mitochondrial fluorescent dye rhodamine 123 is a high-affinity substrate for organic cation transporters (OCTs) 1 and 2.

SLC22A1 SLC22A2

8.35e-062101222913740
Pubmed

HECTD1-Mediated Ubiquitination and Degradation of Rubicon Regulates Autophagy and Osteoarthritis Pathogenesis.

HECTD1 RUBCN

8.35e-062101236121967
Pubmed

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.

CLGN HM13 SLC3A2 STIM1 STEAP3 PLAT

1.31e-05176101628692057
Pubmed

Establishment and Dysfunction of the Blood-Brain Barrier.

ABCC4 SLC22A1 SLC22A2 ABCC2

1.63e-0552101426590417
Pubmed

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.

ABCC4 CYP4A11 PEMT SLC22A1 SLC22A2 ABCC2

2.21e-05193101619343046
Pubmed

Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium.

SLC22A1 SLC22A2

2.50e-053101215817714
Pubmed

OCT2 and MATE1 provide bidirectional agmatine transport.

SLC22A1 SLC22A2

2.50e-053101221128598
Pubmed

Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials.

SLC22A1 SLC22A2

2.50e-053101223545524
Pubmed

Association of the SLC22A1, SLC22A2, and SLC22A3 genes encoding organic cation transporters with diabetic nephropathy and hypertension.

SLC22A1 SLC22A2

2.50e-053101220429798
Pubmed

Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients.

SLC22A2 ABCC2

2.50e-053101227590272
Pubmed

The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling.

DOK1 INPP5D

2.50e-053101222370159
Pubmed

Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice.

ABCC4 ABCC2

2.50e-053101217273943
Pubmed

Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3.

SLC22A1 SLC22A2

2.50e-053101219141712
Pubmed

Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.

SLC22A1 SLC22A2

2.50e-053101220371711
Pubmed

Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).

SLC22A1 SLC22A2

2.50e-053101216141367
Pubmed

Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3.

SLC22A1 SLC22A2

2.50e-053101222806583
Pubmed

Combined pituitary hormone deficiency due to the F135C human Pit-1 (pituitary-specific factor 1) gene mutation: functional and structural correlates.

SLC22A1 SLC22A2

2.50e-053101211222742
Pubmed

Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells.

DPP4 PLAT

2.50e-053101215016824
Pubmed

Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons.

SLC22A1 SLC22A2

2.50e-053101217460754
Pubmed

Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes.

PIK3C2A PRKD1

2.50e-053101224280220
Pubmed

Metformin resistance alleles in polycystic ovary syndrome: pattern and association with glucose metabolism.

SLC22A1 SLC22A2

2.50e-053101224533710
Pubmed

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b.

ABCC4 ABCC2

2.50e-053101225952649
Pubmed

In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1.

SLC22A1 SLC22A2

2.50e-053101224530383
Pubmed

Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers.

ABCC4 ABCC2

2.50e-053101219480556
Pubmed

Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides.

ABCC4 ABCC2

2.50e-053101217485564
Pubmed

Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents.

SLC22A1 SLC22A2

2.50e-053101220477935
Pubmed

Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus.

SLC22A1 SLC22A2

2.50e-053101210051314
Pubmed

Functional characterization of the organic cation transporters (OCTs) in human airway pulmonary epithelial cells.

SLC22A1 SLC22A2

2.50e-053101225883089
Pubmed

The blood-brain barrier choline transporter.

SLC22A1 SLC22A2

2.50e-053101222483271
Pubmed

Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices.

ABCC4 ABCC2

2.50e-053101217578901
Pubmed

Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients.

SLC22A1 SLC22A2

2.50e-053101222735389
Pubmed

A phosphotyrosine switch regulates organic cation transporters.

SLC22A1 SLC22A2

2.50e-053101226979622
Pubmed

Inhibition of human organic cation transporters by the alkaloids matrine and oxymatrine.

SLC22A1 SLC22A2

2.50e-053101224291757
Pubmed

Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.

SLC22A1 SLC22A2

2.50e-053101233375004
Pubmed

Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.

ABCC4 SLC3A2 SLC22A2

3.04e-0521101323137377
Pubmed

Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.

CELSR2 SLC22A1 SLC22A2 ABCC2

4.20e-0566101420679960
Pubmed

Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes.

DOK1 INPP5D

4.99e-054101215151996
Pubmed

Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy.

ABCC4 ABCC2

4.99e-054101218690847
Pubmed

The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua.

SLC22A1 SLC22A2

4.99e-054101217393420
Pubmed

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

PWWP2A PWWP2B

4.99e-054101230228260
Pubmed

Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions.

DOK1 INPP5D

4.99e-054101219682241
Pubmed

Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma.

SLC22A1 SLC22A2

4.99e-054101228714373
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

ABCC4 PCNX3 PIDD1 CHD8 ERMP1 HEXIM2 SLC3A2 TASOR2 PWWP2A NPTN KLLN PRKD1 RUBCN

5.12e-0512151011315146197
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

CLGN ERO1A CHAF1A UGGT1 HM13 SLC3A2 NPTN NAV1 STEAP3 HECTD1

5.57e-057331011034672954
Pubmed

Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.

SLC22A1 SLC22A2 ABCC2

6.61e-0527101320173083
Pubmed

The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE).

KSR2 STIM1

8.30e-055101224672054
Pubmed

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

SLC22A1 SLC22A2

8.30e-055101224961373
Pubmed

Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.

SLC22A1 SLC22A2

8.30e-05510129933568
Pubmed

The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.

DOK1 INPP5D

8.30e-055101210822173
Pubmed

Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.

SLC22A1 SLC22A2

8.30e-055101223228442
Pubmed

Planar cell polarity pathway regulates nephrin endocytosis in developing podocytes.

VANGL2 CELSR2

8.30e-055101223824190
Pubmed

Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.

ABCC4 ABCC2

8.30e-055101219400747
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

CLGN ERO1A UGGT1 HM13 SLC3A2 NUP205 VANGL2 STIM1 NPTN STEAP3 SELENOI

1.03e-049521011138569033
Pubmed

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

NUP205 CELSR2 LRRC8B RUBCN

1.03e-048310149039502
Pubmed

Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity.

VANGL2 CELSR2

1.24e-046101236712970
Pubmed

Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies.

SLC22A1 SLC22A2

1.24e-046101215135235
Pubmed

Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.

SLC22A1 SLC22A2

1.24e-046101211907186
Pubmed

Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia.

SLC22A1 ABCC2

1.24e-046101220720558
Pubmed

Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study.

ABCC4 ABCC2

1.24e-046101216791115
Pubmed

HIV-host interactome revealed directly from infected cells.

CLGN ERO1A HM13 STIM1 LY75

1.51e-04172101527375898
Pubmed

Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome.

ABCC4 ABCC2

1.74e-047101220922799
Pubmed

SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL.

DOK1 INPP5D

1.74e-047101211031258
Pubmed

Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.

CLGN UGGT1 ERMP1 HM13 SLC3A2 STIM1

1.79e-04282101635007762
Pubmed

Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.

SLC22A1 SLC22A2

2.31e-048101211562346
Pubmed

The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.

ANO7 ANO3

2.31e-048101221984732
Pubmed

Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements.

SLC22A1 SLC22A2

2.31e-048101216204191
Pubmed

Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling.

DOK1 INPP5D

2.31e-048101211970986
Pubmed

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

ABCC4 ABCC2

2.31e-048101215802388
Pubmed

The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

SLC22A1 SLC22A2

2.31e-048101219536068
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

ABCC4 SLC22A1 SLC22A2 ABCC2

2.56e-04105101430280653
Pubmed

Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation.

SLC22A1 SLC22A2

2.97e-049101225918552
Pubmed

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.

DOK1 INPP5D

2.97e-049101227926878
GeneFamilyAnoctamins

ANO7 ANO3

5.97e-0410672865
GeneFamilyATP binding cassette subfamily C

ABCC4 ABCC2

1.03e-0313672807
CoexpressionAtlaskidney_adult_RenalCortexMixed_Std_top-relative-expression-ranked_500

TMEM30B DPP4 PDE1A CYP4A11 ACSS2 ADTRP SLC22A1 SLC22A2 ABCC2 PLS1

2.21e-054249610gudmap_kidney_adult_RenalCortexMixed_Std_500
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 ABCC4 SDK2 ERO1A ADTRP STIM1

1.77e-061601016174a4ab27114efcc63be36929b80680be3c35c9b
ToppCell11.5-Airway-Epithelial-Neuroendocrine|Airway / Age, Tissue, Lineage and Cell class

LARGE2 KCNH6 TIGD3 STEAP3 CREG2 PLS1

4.91e-061911016c1bb3ae5c297f55cdadf5b6e53d5296389d5099e
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACSS2 KCNH6 SPDEF ANO7 MUC4 PLS1

5.21e-061931016402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACSS2 KCNH6 SPDEF ANO7 MUC4 PLS1

5.21e-0619310167ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM30B ACSS2 SPDEF ANO7 MUC4 PLS1

5.52e-061951016c5f33b420c9ac14dc67fea632b8c2bc2442cbf3d
ToppCell15-Airway-Epithelial-Epithelial|Airway / Age, Tissue, Lineage and Cell class

CHL1 ST6GALNAC2 SHD CHD5 PLAT ECEL1

5.52e-06195101656356a9aeb67b50a74425be2cd9c50d31416c1b3
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_activated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ADTRP ZBED10P VANGL2 KDM2B LY75

9.40e-061241015e16be7805c91db12b1110c90cd39492913f1d3ea
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 ABCC4 ERO1A KSR2 ADTRP

3.31e-051611015176a4a72bb4892932da3c834d1fea5e211847f92
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADTRP FBXL5 CDH24 MUC4 PLS1

3.41e-051621015dddf7a3901ae59e3494d8a6740db0fa15cc96d47
ToppCelldroplet-Lung-LUNG-30m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADTRP FBXL5 CDH24 MUC4 PLS1

3.41e-0516210152a4e09545e9874519f0f56e81065104987d81cd6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 ABCC4 ADTRP STIM1 MUC4

4.17e-0516910152a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIDD1 KCNH6 SPDEF ANO7 MUC4

4.29e-0517010152c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIDD1 KCNH6 SPDEF ANO7 MUC4

4.29e-0517010159bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CHAF1A TRPC5 SHD TIGD3 RUBCN

4.41e-0517110154fd2c7977c512c51507f055fc74b111c0228ed8b
ToppCellLymphoid-Lymphoid-B_cells_(cycle)|Lymphoid / shred on cell class and cell subclass (v4)

CHAF1A GDF9 FANCF PWWP2B ATG4C

4.54e-051721015f39822afcc35f0fbf68b8ffd1894e4b6c8d7a80c
ToppCellfacs-Marrow-T_cells-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLGN HM13 SLC3A2 CREG2 PLS1

4.66e-051731015e0cf99ddbe6e9eab05d7bf89e9aa124850c6a807
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TCAF2 DPP4 SDK2 ADTRP CDH24

4.79e-051741015912a9e892b29d945666fc37c986009c97c668ac8
ToppCellPND10-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHL1 LARGE2 ERMP1 PEMT MUC4

4.79e-05174101597d4a40b536a67fa52f055eab26106d041bf3220
ToppCellPND10-Epithelial-Epithelial_Airway-Basal-Basal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHL1 LARGE2 ERMP1 PEMT MUC4

4.79e-051741015f9f399244c7d12caf8118ec3117d477a39e35c3b
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC4 SDK2 PIK3C2A CAPN7 MUC4

4.79e-051741015f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DPP4 PDE1A SDK2 ADTRP CDH24

4.79e-051741015e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCellPND10-Epithelial-Epithelial_Airway-Basal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHL1 LARGE2 ERMP1 PEMT MUC4

4.79e-051741015e8440eea7c81864defa57c89e9b569ad8033e5c5
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DPP4 SDK2 ADTRP CDH24 ANO3

4.79e-0517410157d4b860e05b5931f6f9d757a68f75ff35597a47a
ToppCellfacs-Marrow-T_cells-18m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLGN HM13 SLC3A2 CREG2 PLS1

4.92e-0517510154be01bf30331162f1998216fb2871a4e626dc440
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 ABCC4 ADTRP STIM1 SELENOI

4.92e-0517510151d8da48236549c01381f777ce5b2937f9f86acc2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 PDE1A ABCC4 ADTRP STIM1

4.92e-05175101598947a226b5a2ac7091ff9d34243ea7736add973
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SDK2 UGGT1 KSR2 CAPN7 MUC4

5.34e-051781015fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A SDK2 ADTRP VANGL2 STIM1

5.63e-051801015b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCellmoderate-Myeloid-pDC|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DPP4 SDK2 CHAF1A SHD RUBCN

5.63e-0518010151d8df7df03a71f49d6683554d3c948ce90dda42e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DPP4 PDE1A ADTRP CDH24 ANO3

5.63e-051801015e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A SDK2 ADTRP VANGL2 STIM1

5.78e-05181101508f44323bf71b6004a921bbc969c954c75feeb66
ToppCellSevere-Lymphoid-pDC|Severe / Condition, Lineage, Cell class and cell subclass

SDK2 CHAF1A SHD ECEL1 RUBCN

5.78e-0518110152caecb7c5dcdad46fd02b4ffb73cb613ce835187
ToppCellSevere-Lymphoid-pDC-|Severe / Condition, Lineage, Cell class and cell subclass

SDK2 CHAF1A SHD ECEL1 RUBCN

5.78e-051811015277ce4c49121da0990a5933b19d2c6af9bbe253e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CYP4A11 KCNH6 SLC22A2 ABCC2 PLS1

6.57e-051861015b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

DPP4 CYP4A11 ACSS2 SLC22A2 ABCC2

6.74e-051871015acd305475f3609800af0d7bc68d83ef41228080b
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Mbp_(Mbp)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KLK9 MUC4 PLS1 SEC14L5

6.78e-059610149673d03916705c675686bb4282dedd3dc5e98625
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Mbp_(Mbp)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KLK9 MUC4 PLS1 SEC14L5

6.78e-059610147e2810f5f5a17fcc7ae40edfd3e885740b575e29
ToppCellsevere_COVID-19-CD4+_T_naive|World / disease group, cell group and cell class (v2)

TMEM30B DPP4 KSR2 ADTRP TXK

7.45e-05191101555a282478488efd1561ea57a6f0218f55f711bb0
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LARGE2 TMEM30B PDE1A KSR2 KCNH6

7.82e-051931015aa10924b203c71e65fdbd2b90ba131dbd362d8b1
ToppCellPCW_07-8.5-Epithelial|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LARGE2 TMEM30B PDE1A KSR2 PLS1

8.02e-051941015f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACSS2 SPDEF ANO7 MUC4 PLS1

8.21e-0519510157ff04c45a02df01e3816f3c1d43585a93182a730
ToppCellBronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SDK2 CHAF1A SHD TIGD3 RUBCN

8.21e-051951015fbc324c3435f32b9ca269d83333faecfe940d7fe
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-Goblet_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM30B ACSS2 SPDEF ANO7 MUC4

8.21e-051951015219c5d0cde7f6082755154f54db221413ec555cb
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACSS2 SPDEF ANO7 MUC4 PLS1

8.21e-05195101509605533aa5947bb2e5a6725c1ce89f79d330bf5
ToppCellParenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SDK2 CHAF1A SHD TIGD3 RUBCN

8.41e-051961015b10b386aacc672949560df2dbb0d4f76cf62e213
ToppCelldistal-Epithelial-Goblet|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CHL1 LARGE2 SPDEF MUC4 PLS1

8.62e-051971015da1ed7303cc9cb2d205c0e5c49c52544d3540951
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CHL1 TMEM30B ERMP1 SPDEF PLS1

8.62e-051971015d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCelldistal-3-Epithelial-Goblet|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CHL1 LARGE2 SPDEF MUC4 PLS1

8.62e-051971015a00784ccfb1de6a96b91e2a8a2889b69f31a33da
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CHL1 TMEM30B ERMP1 SPDEF PLS1

8.62e-05197101580b05c8ad9c1edc5dea3236079372475431343fe
ToppCellSevere_COVID-19-Epithelial-transitional_Epi|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

CHL1 DYNC2H1 SPDEF MUC4 PLS1

8.62e-0519710155ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCelldistal-Epithelial-Goblet-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CHL1 LARGE2 SPDEF MUC4 PLS1

8.62e-0519710153fbf456ae4f73da4f6254a6f0d24f0ec27d7a3cc
ToppCelldistal-Hematologic-Plasmacytoid_Dendritic|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SDK2 CHAF1A TRPC5 SHD TIGD3

8.83e-051981015bb03744d8372405c278a0781e2f513bed00cf2b3
ToppCelldistal-Hematologic-Plasmacytoid_Dendritic-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SDK2 CHAF1A TRPC5 SHD RUBCN

9.25e-052001015ef42753c9fbe3770e3f415cd7ab412654d359edb
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2-OR2T8|Neuronal / cells hierarchy compared to all cells using T-Statistic

SDK2 ADTRP VANGL2 CDH24 CLDN24

9.25e-0520010155fa4d589f5c5f7891dccfc877d6d0929d5e85436
ToppCellBronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ABCC4 NAV1 KDM2B LY75 RUBCN

9.25e-052001015a4c41509ca936e137230a6ae548c90f18a566d12
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2-OR2T8--L6|Neuronal / cells hierarchy compared to all cells using T-Statistic

SDK2 ADTRP VANGL2 CDH24 CLDN24

9.25e-05200101570ab4d65d1a6b93459d44bdfe974d3ad90d0ab83
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2-OR2T8-|Neuronal / cells hierarchy compared to all cells using T-Statistic

SDK2 ADTRP VANGL2 CDH24 CLDN24

9.25e-0520010156e428c0bff8c8feffaae6ff21dcfd22476ad7082
Diseaseextrahepatic cholestasis (biomarker_via_orthology)

ABCC4 SLC22A1 SLC22A2

2.41e-0517993DOID:13619 (biomarker_via_orthology)
Diseaseintrahepatic cholestasis (biomarker_via_orthology)

SLC22A1 SLC22A2

1.11e-045992DOID:1852 (biomarker_via_orthology)
Diseaseadipoylcarnitine (C6-DC) measurement

CYP4A11 SLC22A1

1.66e-046992EFO_0800380
Diseaseplasma betaine measurement

PEMT SLC22A1 LY75

2.03e-0434993EFO_0007787
Diseasepimeloylcarnitine/3-methyladipoylcarnitine (C7-DC) measurement

CYP4A11 SLC22A1

3.08e-048992EFO_0800494
Diseasetotal lipids in small LDL

CELSR2 SLC22A1 SLC22A2

5.34e-0447993EFO_0022168
Diseasefree cholesterol in medium VLDL measurement

CELSR2 SLC22A1 SLC22A2

5.34e-0447993EFO_0022269
Diseaselipoprotein A measurement

PEMT CELSR2 SLC22A1 SLC22A2

5.61e-04112994EFO_0006925
DiseaseGastrointestinal Diseases

CHD8 ABCC2

7.20e-0412992C0017178
DiseaseFunctional Gastrointestinal Disorders

CHD8 ABCC2

7.20e-0412992C0559031
DiseaseCholera Infantum

CHD8 ABCC2

7.20e-0412992C1565321
Diseaseunipolar depression, anxiety

ADTRP CLDN24

9.88e-0414992EFO_0003761, EFO_0005230
Diseasephospholipids in small VLDL measurement

CELSR2 SLC22A1 SLC22A2

1.09e-0360993EFO_0022146
Diseasecholesterol to total lipids in chylomicrons and extremely large VLDL percentage

CELSR2 SLC22A1

1.47e-0317992EFO_0022232
Diseasecoronary artery disease

PDE1A PCNX3 DYNC2H1 INPP5D KSR2 PEMT CELSR2 SLC22A1 SLC22A2 SELENOI PARP12

2.22e-0311949911EFO_0001645
Diseasestroke, coronary artery disease

PEMT CELSR2

2.24e-0321992EFO_0000712, EFO_0001645
Diseasecholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage

CELSR2 SLC22A1

2.24e-0321992EFO_0022246
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

PEMT CELSR2 SLC22A1 SLC22A2 SPDEF

3.03e-03291995EFO_0008317, EFO_0020946
Diseaselarge artery stroke, coronary artery disease

PEMT CELSR2

3.18e-0325992EFO_0001645, EFO_0005524

Protein segments in the cluster

PeptideGeneStartEntry
PTIQYHKERWLAKQW

VANGL2

446

Q9ULK5
HAAGSQGWVPWKYRV

C21orf140

76

B9A014
KHLLVYGWGRWRDIL

CHD8

1451

Q9HCK8
WILSIITTYLPHWKN

CLDN24

21

A6NM45
HPYQLEGLNWLRFSW

CHD5

701

Q8TDI0
PGNHFIWYRGKWIRV

BCS1L

101

Q9Y276
SIYLLGEKLNHWKWG

ADTRP

206

Q96IZ2
KARYHWLVLPWTSIS

APTX

211

Q7Z2E3
RLIANTLHWWYFGPD

CMTR2

191

Q8IYT2
CPHWLWGGKVRVQLY

CYP4A11

86

Q02928
LHNPSSWGKVWYLNE

ADARB2-AS1

121

A8MUL3
LPEHNLSYAWAWPRV

NPR2

31

P20594
AWHGLSLPISQPWYL

CELSR2

1626

Q9HCU4
AHLPAEVWEKYRKWL

AADACL3

271

Q5VUY0
PINPEAWLWYHRVVG

ACSS2

441

Q9NR19
HRPAYWGTWNKKTAL

CHAF1A

566

Q13111
RIEHIWLQKWYGGAS

CREG2

261

Q8IUH2
FPWYLPVHFLIRKNW

ERMP1

746

Q7Z2K6
LHFLGRAWTWPDALN

ATG4C

126

Q96DT6
LGYPLIQNWWSRHKI

ANO3

711

Q9BYT9
YLGNLWKNHRPWPAL

LARGE2

236

Q8N3Y3
PYKDIWHKVGNALWR

NUP205

16

Q92621
ARWGKWNKYQPLDHV

ANO7

321

Q6IWH7
RWALKVTWVNAHAYP

MUC4

4446

Q99102
DKTLSHPWLQDYQTW

PRKD1

831

Q15139
WGQRLHYDLQKGIWV

FANCF

281

Q9NPI8
DRVHGRLKGYQINWW

CHL1

836

O00533
GTIWYELHAREWPFK

KSR2

861

Q6VAB6
RWTILHYSPFKAVWD

KCNH6

246

Q9H252
INFRDLGWHKWIIAP

GDF3

271

Q9NR23
RHAPYLVPIELWDWG

CDH24

586

Q86UP0
RAQHSYKYWLLPGRW

PCNX3

756

Q9H6A9
LLLRWVNYHLTNAGW

PLS1

271

Q14651
WVNLAKTYSLLHQWP

PIK3C2A

921

O00443
DISHPAKSWKLHYRW

PDE1A

366

P54750
HLVVLKSWYPFWGAA

MS4A10

86

Q96PG2
ARGWEWSDHKPLNFL

LY75

286

O60449
TWSPVGHKLAYVWNN

DPP4

156

P27487
IVGVWYLLRKHWIAN

HM13

171

Q8TCT9
WLLAPWQLLHVYKSR

ABCC2

41

Q92887
PGRTVHVWGYRVEWK

KLLN

11

B2CW77
APERKWPWQVSVHYA

PRSS38

66

A1L453
TPHLRWKWLLDQIFQ

ECEL1

351

O95672
ADAQSSYHILKPWWD

LRRC8B

11

Q6P9F7
HLPYRWQFLDRGKWE

PARP12

296

Q9H0J9
PLYWNVVARWEHKTR

PEMT

26

Q9UBM1
RVFFWWLNPLFKIGH

ABCC4

21

O15439
LTGQVWQRYVPHPWK

DYNC2H1

301

Q8NCM8
QQGKPYHWRDWSIIR

HECTD1

656

Q9ULT8
WYHVFRGGKIFWLIP

KDM2B

251

Q8NHM5
RWRKTWAVLYPASPH

DOK1

21

Q99704
LKNPWSHLRWKGRYS

CAPN7

476

Q9Y6W3
ANGLPKHSYWLDLWL

C4orf3

36

Q8WVX3
IAWWTDYHVKFRNPP

TMEM30B

196

Q3MIR4
RELPAQKWWHTGALY

SLC3A2

211

P08195
QKWWHTGALYRIGDL

SLC3A2

216

P08195
YLLQETWLEKKWGHN

ERO1A

266

Q96HE7
HWEKYNTGILFLPWG

SELENOI

171

Q9C0D9
KPYLWVRLGEHHLWK

KLK9

66

Q9UKQ9
KWDNWIVAPHRYNPR

GDF9

366

O60383
TGSLWKHLYPVHWAR

FBXL5

241

Q9UKA1
WLHPSGWTIEILNAY

LINC00587

6

B1AMM8
KLPYHATLGIQRWWD

ENPP7

106

Q6UWV6
FPHPLWLRDTYKLWV

PWWP2B

126

Q6NUJ5
YWQFVKDIRWLSPHS

RUBCN

81

Q92622
GSHVTRWPGVYLLQW

SEC14L5

601

O43304
EGSWPLEFKWLHNNR

SDK2

51

Q58EX2
LTGLAYALPHWRWLQ

SLC22A1

251

O15245
VLAGVAYALPHWRWL

SLC22A2

251

O15244
QIWGKAAIGLYLWEH

RXYLT1

101

Q9Y2B1
LLWKHWLREPAFYQV

MFSD12

266

Q6NUT3
HPWKLGFSKITYREW

HELB

251

Q8NG08
AYWDNILGPRVRHIW

C9orf72

31

Q96LT7
RLHLLYWAPPAATWD

PIDD1

551

Q9HB75
ELLRVLDWVPKLWYH

NAV1

1711

Q8NEY1
RFPGQSVYHIKWIQW

MINDY2

236

Q8NBR6
AKIYGFPWWPARILT

PWWP2A

661

Q96N64
RWHSDGIVYPKPTWL

TRMT44

256

Q8IYL2
YDQPWEWKKDHISRA

SHD

181

Q96IW2
WYWASQHGPDKVLSR

TCAF2

156

A6NFQ2
WYHEGPNSLKVARLW

PRPF4

166

O43172
HWRPYLELSWAEKQQ

HEXIM2

101

Q96MH2
WCDRVLWKSYPLVHV

INPP5D

671

Q92835
LWDRLSQHKAPYGWR

ST6GALNAC2

101

Q9UJ37
WYAPEALQKWLQLTH

STIM1

341

Q13586
AEGHPWLWLIYLVTA

CLGN

466

O14967
LAPYNWPVWLGVHDR

CLEC11A

231

Q9Y240
LTLIVLFWGSKHFWP

TNMD

41

Q9H2S6
WYHIARAKAWDVTGP

TIGD3

86

Q6B0B8
LKLWVWQGSVPRLHD

TAS1R3

456

Q7RTX0
PWCHVLKNRRLTWEY

PLAT

276

P00750
TKYQRFPDWLDHWLQ

STEAP3

286

Q658P3
QKWLLWTEHQYRLPP

SPDEF

156

O95238
SVGYPHPDWIWRKKE

NPTN

261

Q9Y639
WGPTDIDHWKQVLVY

ZBED10P

91

Q96FA7
IHWYWQKPNKGLEYL

TRGV11

51

A0A075B6L2
ILEKYNPHWWKARDR

TXK

111

P42681
RSPQVWLGHLLKAWF

ZNF852

521

Q6ZMS4
HAWSRPLWYQVGLDL

TMEM89

21

A2RUT3
EKLNGNGRWKWLLHY

TASOR2

2306

Q5VWN6
YDGFPGWRRKHWVVK

TRPC5

316

Q9UL62
HTPWIVIIAKYLAQW

NAE1

211

Q13564
LVQYKWPRWLHQQTE

UGGT1

1316

Q9NYU2