Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin protein ligase activity

RNF213 RNF150 VPS18 ARIH1 RNF217

3.37e-04372335GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RNF213 RNF150 VPS18 ARIH1 RNF217

4.60e-04398335GO:0061659
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

RNF213 RNF150 VPS18 ARIH1 RNF217

1.00e-03473335GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RNF213 RNF150 VPS18 ARIH1 RNF217

1.42e-03512335GO:0019787
GeneOntologyMolecularFunctionacyltransferase activity

RNF213 RNF150 KMT2C VPS18 ARIH1 RNF217

1.51e-03775336GO:0016746
GeneOntologyMolecularFunctionubiquitin conjugating enzyme binding

ARIH1 RNF217

1.61e-0336332GO:0031624
GeneOntologyMolecularFunctionaminoacyltransferase activity

RNF213 RNF150 VPS18 ARIH1 RNF217

1.69e-03532335GO:0016755
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme binding

ARIH1 RNF217

2.19e-0342332GO:0044390
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

RNF213 USP2 VPS18 SLF1 ARIH1 MARCHF10 EID3 RNF217 DCAF5

2.68e-051009349GO:0070647
GeneOntologyBiologicalProcesspost-translational protein modification

RNF213 USP2 VPS18 SLF1 ARIH1 MARCHF10 EID3 RNF217 DCAF5

4.38e-051074349GO:0043687
GeneOntologyBiologicalProcessprotein modification by small protein conjugation

RNF213 VPS18 SLF1 ARIH1 MARCHF10 EID3 RNF217 DCAF5

7.96e-05893348GO:0032446
GeneOntologyCellularComponentSmc5-Smc6 complex

SLF1 EID3

9.18e-059342GO:0030915
GeneOntologyCellularComponentinclusion body

SLF1 ARIH1 EDEM1

4.19e-0490343GO:0016234
GeneOntologyCellularComponentSUMO ligase complex

SLF1 EID3

5.29e-0421342GO:0106068
DomainNPIP

NPIPA1 NPIPA3 NPIPA7 NPIPA2 NPIPA5

5.24e-1114385IPR009443
DomainZF_RING_2

RNF213 RNF150 KMT2C VPS18 ARIH1 RNF217

2.82e-05298386PS50089
DomainZnf_RING

RNF213 RNF150 KMT2C VPS18 ARIH1 MARCHF10

4.66e-05326386IPR001841
DomainE3_UB_ligase_RBR

ARIH1 RNF217

1.80e-0410382IPR031127
DomainIBR

ARIH1 RNF217

3.61e-0414382PF01485
DomainIBR

ARIH1 RNF217

3.61e-0414382SM00647
DomainIBR_dom

ARIH1 RNF217

4.16e-0415382IPR002867
Domain-

RNF213 RNF150 KMT2C ARIH1 MARCHF10

2.05e-034493853.30.40.10
DomainZnf_RING/FYVE/PHD

RNF213 RNF150 KMT2C ARIH1 MARCHF10

2.26e-03459385IPR013083
DomainZF_RING_1

RNF150 VPS18 ARIH1 RNF217

2.81e-03291384PS00518
DomainRING

RNF213 RNF150 KMT2C ARIH1

3.32e-03305384SM00184
DomainZnf_C3HC4_RING-type

RNF213 RNF150 MARCHF10

5.11e-03172383IPR018957
Domainzf-C3HC4

RNF213 RNF150 MARCHF10

1.04e-02223383PF00097
Pubmed

Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling.

NPIPA1 NPIPA3 NPIPA2 NPIPA5

1.35e-12439418055785
Pubmed

Positive selection of a gene family during the emergence of humans and African apes.

NPIPA1 NPIPA8

1.23e-06239211586358
Pubmed

USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination.

USP2 NPIPA3

1.83e-05639236567903
Pubmed

Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.

SLF1 EID3

4.39e-05939216810316
Pubmed

Molecular Insights into the Architecture of the Human SMC5/6 Complex.

SLF1 EID3

4.39e-05939232389690
Pubmed

The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins.

SLF1 EID3

9.48e-051339217589526
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

RNF213 RNF150 ARIH1

1.68e-049539329643511
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RNF213 VPS18 SYNM WDFY4 SLCO2B1

2.17e-0449339515368895
Pubmed

Association of gene polymorphisms with chronic kidney disease in Japanese individuals.

CDYL2 MARCHF10

8.84e-043939219724895
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

KMT2C TUT1 METTL21A DCAF5 COQ8B

9.92e-0468939536543142
InteractionNPIPA3 interactions

USP2 NPIPA3

3.10e-062362int:NPIPA3
InteractionCRACR2B interactions

USP2 TIMM29 ZBTB25

1.03e-0524363int:CRACR2B
Cytoband16p13.11

NPIPA1 NPIPA3 NPIPA2 NPIPA5

3.89e-092339416p13.11
CytobandEnsembl 112 genes in cytogenetic band chr16p13

NPIPA1 NPIPA3 NPIPA7 NPIPA2 NPIPA5

2.98e-05426395chr16p13
Cytoband2q33.3

CRYGC METTL21A

3.01e-04303922q33.3
GeneFamilyRing finger proteins

RNF213 RNF150 MARCHF10 RNF217

5.15e-0427525458
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TAOK2 RNF213 KMT2C SLF1 SLCO2B1

8.41e-07200395dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Neuron|GW19 / Sample Type, Dataset, Time_group, and Cell type.

NPIPA1 SLCO2B1 ZBTB25 STC1

1.64e-051753942812ac2ef41d245db544697fb6da1883361c96e8
ToppCell3'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 RNF150 SYNM NPIPA5

2.21e-0518939463449d9f1e78ff2bc8786eb88a0d177fe30c7f4d
ToppCell3'-Adult-LargeIntestine-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 RNF150 SPOCD1 SYNM

2.21e-05189394f7e2ee5047792ab9ef6472fa88e2d193cdea6fa0
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 RNF150 SYNM SLCO2B1

2.50e-051953941be9502577267ca2a04656a99d57e3e2f124d92e
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

USP2 COL6A1 RNF150 SYNM

2.65e-0519839422e766df1276c5b14aa0d83f434f47140ebb98ea
DrugMAR70

ARIH1 SARS1 EDEM1 STC1

6.16e-0678354CID000004013
DrugThiamine hydrochloride [67-03-8]; Up 200; 11.8uM; MCF7; HT_HG-U133A

USP2 TUT1 ZBTB25 PICK1 STC1

1.18e-051963557479_UP
DrugDiazald

NPIPA1 SYNM

2.29e-055352CID000006628
Drugtrimethyl phosphate

SARS1 C9 SYNM

2.93e-0539353CID000010541
Drugindene

NPIPA1 CRYGC EDEM1 SYNM

3.39e-05120354CID000007219
Drugdihydrofuran

NPIPA1 SYNM

3.43e-056352CID000070934
DrugDNPz

NPIPA1 SYNM

4.80e-057352CID000008819
Diseasephosphatidylcholine 40:7 measurement

NPIPA1 NPIPA2

1.06e-0413352EFO_0021477
Diseaselysophosphatidylcholine 20:3 measurement

NPIPA1 NPIPA2

1.04e-0340352EFO_0010362
Diseaseretinal nerve fibre layer thickness measurement

NPIPA1 NPIPA2

1.20e-0343352EFO_0600004
Diseasecholesteryl ester 20:3 measurement

NPIPA1 NPIPA2

1.55e-0349352EFO_0010347
Diseasetriglycerides to total lipids in medium LDL percentage

NPIPA1 NPIPA2

1.62e-0350352EFO_0022334
Diseasetriglycerides to total lipids in large LDL percentage

NPIPA1 NPIPA2

1.68e-0351352EFO_0022331
Diseasetriglycerides to total lipids in small VLDL percentage

NPIPA1 NPIPA2

2.17e-0358352EFO_0022338
Diseaseretinal layer thickness measurement

NPIPA1 NPIPA2

2.32e-0360352EFO_0600002
Diseasephosphatidylcholine measurement

NPIPA1 TUT1 NPIPA2

4.60e-03284353EFO_0010226
Diseasecholesteryl ester measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2

5.58e-0394352EFO_0008595, EFO_0010351
Diseaselipid measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2

5.81e-0396352EFO_0004529, EFO_0008595
Diseasephospholipid measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2

6.17e-0399352EFO_0004639, EFO_0008595
Diseasetotal cholesterol measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2

6.17e-0399352EFO_0004574, EFO_0008595
Diseasefree cholesterol measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2

6.79e-03104352EFO_0008591, EFO_0008595

Protein segments in the cluster

PeptideGeneStartEntry
QRAQALRRRAEDYYR

NPIPA1

186

Q9UND3
RSRAALQRYLFYCNR

ARIH1

406

Q9Y4X5
YRNYREEDLILQCRQ

KMT2C

1091

Q8NEZ4
SCRRNVKYRRVQNYL

KCNQ5

101

Q9NR82
RRQYRQLMYCVRQNR

EID3

41

Q8N140
QDFQRRRLRGCRNLY

DCAF5

31

Q96JK2
QRAQALRRRAEDYYR

NPIPA3

186

F8WFD2
RAQALRRRAEDYYRC

NPIPA2

206

E9PIF3
LACRIRYERDNNFLA

METTL21A

171

Q8WXB1
DNLRDRYYRCDRNLV

COL6A1

71

P12109
DYRREAACAQNFRQL

COQ8B

286

Q96D53
YQSIQNYLRRGREAC

EDEM1

396

Q92611
DSEYQACLRRQEYRR

MARCHF10

26

Q8NA82
NLSAVNRQALRYYRC

KLB

611

Q86Z14
GRQYLLRPQEYRRCQ

CRYGC

141

P07315
LYARIYCQVRANARR

S1PR5

211

Q9H228
CNRDRDGNTLTYYRR

C9

181

P02748
QRAQALRRRAEDYYR

NPIPA7

186

E9PJI5
QRAQALRRRAEDYYR

NPIPA8

186

P0DM63
YIQRFRYANARDRNQ

RNF150

231

Q9ULK6
SNCTDYQARRLRIRY

SARS1

396

P49591
RGIRRNASQCYLYQE

TMC3

11

Q7Z5M5
QASLYQARCRYLQPR

TIMM29

141

Q9BSF4
QELNARLYDYVCRVR

SYNM

16

O15061
QRAQALRRRAEDYYR

NPIPA5

186

E9PKD4
LLRRQRQYFELQCRQ

TAOK2

631

Q9UL54
TNFCYRCGERYRQLR

RNF217

446

Q8TC41
SNRYYNRLVRSLLEC

STC1

156

P52823
LRYSVRQNESNCRFR

CDYL2

236

Q8N8U2
YRYNRCQRFGNALAQ

ZBTB25

376

P24278
RNFARFLNYQLRDCE

RNF213

2216

Q63HN8
RAVCRYYNNDLLRNR

SLCO2B1

636

O94956
ANYCRSLQYQRRSSR

TUT1

571

Q9H6E5
QNCRLLYSYLNDRQR

SPOCD1

941

Q6ZMY3
QRRYLESARCYALTQ

VPS18

436

Q9P253
CIENYRRRGQELYAS

WDFY4

2226

Q6ZS81
IYRAQAVRYNCIRID

SLF1

381

Q9BQI6
SNTRELRDYCLQRLY

USP2

286

O75604
NYEYRLILRCRQEAR

PICK1

291

Q9NRD5