Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainSAM_1

PPFIA2 SAMD7

2.88e-0368222PF00536
DomainSAM

PPFIA2 SAMD7

4.77e-0388222SM00454
DomainSAM_DOMAIN

PPFIA2 SAMD7

5.53e-0395222PS50105
DomainSAM

PPFIA2 SAMD7

5.76e-0397222IPR001660
Domain-

PPFIA2 SAMD7

6.84e-031062221.10.150.50
DomainSAM/pointed

PPFIA2 SAMD7

8.28e-03117222IPR013761
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

CCAR1 CHD9 RPTOR RPL7 UBA1 EIF3L PSMB4 MRPS21

3.01e-07115322829845934
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

CCAR1 RPL7 UBA1 EIF3L MRPS21 NCOA5

8.32e-0680722622681889
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

CCAR1 CHD9 RPL7 UBA1 EIF3L NCOA5

8.44e-0680922632129710
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

CHD9 RPTOR RPL7 UBA1 EIF3L

1.22e-0549422526831064
Pubmed

Molecular and functional architecture of striatal dopamine release sites.

RIMS2 PPFIA2

2.09e-051122234767769
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CCAR1 CHD9 UBA1 EIF3L PSMB4 NCOA5

3.03e-05101422632416067
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

ZNF548 RPL7 UBA1 EIF3L NCOA5

7.09e-0571422528302793
Pubmed

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.

RPTOR UBA1

1.14e-042522230340022
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

ECE1 CCAR1 UBA1 EIF3L PSMB4 MRPS21

1.19e-04129722633545068
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

CCAR1 RPTOR RPL7 UBA1 EIF3L PSMB4

1.50e-04135322629467282
Pubmed

The synaptic vesicle cycle.

RIMS2 PPFIA2

1.76e-043122215217342
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

PPFIA2 HOOK2

1.76e-043122225838543
Pubmed

High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.

RPL7 UBA1 EIF3L PSMB4

1.97e-0446922437314180
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

CCAR1 RPTOR RPL7 UBA1 EIF3L NCOA5

1.98e-04142522630948266
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

CHD9 RPL7 UBA1

2.05e-0418322336129980
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

ZC3H3 RPL7 UBA1 EIF3L

2.10e-0447722431300519
Pubmed

Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.

CCAR1 RPL7 MRPS21

2.22e-0418822329721183
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CCAR1 CHD9 RPTOR PPFIA2 HOOK2 PRKRIP1

2.52e-04148922628611215
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

RPTOR RPL7 VPS13D PSMB4 MRPS21 NCOA5

2.58e-04149622632877691
Pubmed

A proteomic snapshot of the human heat shock protein 90 interactome.

RPL7 UBA1

2.94e-044022216263121
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

CDC25A RPL7 EIF3L PSMB4 MRPS21

2.98e-0497122533306668
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

CHD9 RPTOR UBA1

2.99e-0420822333230847
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

RPL7 UBA1 EIF3L PSMB4

3.23e-0453422435032548
Pubmed

A functional reference map of the RNF8 interactome in cancer.

RPL7 EIF3L PSMB4

3.43e-0421822335831895
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

ECE1 PPFIA2 VPS13D UBA1 PRKRIP1

3.67e-04101622519056867
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

CCAR1 VPS13D HOOK2 PSMB4

3.97e-0456422421565611
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

RIMS2 RPL7 PPFIA2

4.06e-0423122316452087
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

CDC25A PPFIA2 UBA1 EIF3L

4.21e-0457322428330616
Pubmed

The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.

CCAR1 UBA1 NCOA5

4.48e-0423922326641092
Pubmed

FBXO22 degrades nuclear PTEN to promote tumorigenesis.

RPL7 UBA1

5.16e-045322232249768
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

CCAR1 RPL7 EIF3L NCOA5

5.17e-0460522428977666
Pubmed

Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.

RPL7 UBA1 EIF3L

5.60e-0425822321081666
Pubmed

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.

RPL7 EIF3L PSMB4 MRPS21

5.81e-0462422433729478
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

CDC25A RPL7 UBA1 EIF3L NCOA5

5.82e-04112422521900206
Pubmed

Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.

RPL7 PSMB4

6.18e-045822222645313
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

CCAR1 RPL7 UBA1 EIF3L

6.31e-0463822433239621
Cytoband1q21

PSMB4 MRPS21

8.75e-04912221q21
CytobandEnsembl 112 genes in cytogenetic band chr1q21

PSMB4 MRPS21

1.59e-02404222chr1q21
GeneFamilySterile alpha motif domain containing

PPFIA2 SAMD7

1.76e-0388132760
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECE1 RPL7 HOOK2

6.47e-05160223445cef1f2f3279672620664792d4eec54df71bdb
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPFIA2 PGLYRP2 HOOK2

7.09e-05165223475905d608fac628960188ae4a18010b8097417e
ToppCell10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-MPP_myeloid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RPL7 PGLYRP2 EIF3L

7.09e-05165223dc70e050465d1f05bb4115356dc978aa581149b5
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPL7 HOOK2 EIF3L

1.20e-04197223c552d88dca9074e4142372674a426cb61020629f
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPL7 HOOK2 EIF3L

1.20e-041972230b6a0e4a634438e8aa95dd03c409b0e9cbd4dcc8
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature2_(2)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RPL7 EIF3L MRPS21

1.22e-0419822389e25687b614525548279e5fa293c66f5c4abec3
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

RIMS2 PPFIA2 EIF3L

1.23e-041992231b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

RIMS2 PPFIA2 EIF3L

1.23e-041992234bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPL7 HOOK2 EIF3L

1.23e-041992238be5ebed3a4053715f69156bbbb159d501a5c197
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ECE1 CHD9 HOOK2

1.23e-0419922332bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCellcontrol-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ECE1 CHD9 HOOK2

1.23e-041992233d01f90ffd271ca00129192787e4921bdca7e01e
ToppCellcontrol-Epithelial-Secretory|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ECE1 CHD9 HOOK2

1.23e-04199223262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPL7 HOOK2 EIF3L

1.23e-041992234f79645fb9e229a4a4bf3a1b1bb9760bb4605f96
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma|TCGA-Liver / Sample_Type by Project: Shred V9

ZC3H3 PSMB4 MRPS21

1.25e-042002239cff8be6e566f342fc8b45e93106d033b14759ee
ToppCellTCGA-Liver-Primary_Tumor|TCGA-Liver / Sample_Type by Project: Shred V9

ZC3H3 PSMB4 MRPS21

1.25e-04200223b667168081393433597f6ca8baeddba1d1906d40
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma|TCGA-Liver / Sample_Type by Project: Shred V9

ZC3H3 PSMB4 MRPS21

1.25e-04200223bc7aba2885ca1093fcd884807b497700dae4835e
DiseaseS-6-hydroxywarfarin measurement

ZC3H3 CHD9 RPTOR

2.17e-03368213EFO_0803326
Diseaseobsolete_red blood cell distribution width

ECE1 HOOK2 EIF3L PSMB4 MRPS21

2.17e-031347215EFO_0005192
Diseasecomparative body size at age 10, self-reported

CDC25A ECE1 RPTOR

3.15e-03420213EFO_0009819
Diseaseneuroticism measurement

ECE1 PPFIA2 HOOK2 NCOA5

3.52e-03909214EFO_0007660
Diseaseautism spectrum disorder (implicated_via_orthology)

RIMS2 CHD9

5.19e-03152212DOID:0060041 (implicated_via_orthology)
Diseaseneutrophil measurement

ZC3H3 PRKRIP1

6.97e-03177212EFO_0803548

Protein segments in the cluster

PeptideGeneStartEntry
CDMMELRRRYQNLYI

CCAR1

376

Q8IX12
RCMRVLYYRDARSYN

PSMB4

216

P28070
FAYLMMRRYQDAIRV

EIF3L

321

Q9Y262
MEERYRRYVDKARMV

HOOK2

596

Q96ED9
KCRSIRRQYRQLMYC

EID3

36

Q8N140
DFTRCAANMRSMQRY

PGLYRP2

421

Q96PD5
MYDRYRDMRDSRDPM

NCOA5

106

Q9HCD5
YVACLEREVRMRRYR

GDPD4

126

Q6W3E5
YRQMYRTEIRMARMA

RPL7

61

P18124
RRREYQRQDYMDAMA

PRKRIP1

86

Q9H875
RRAAMENQRSYSMER

RIMS2

431

Q9UQ26
YLYAFMSMCRRVCRL

CHD9

1886

Q3L8U1
RKAQVYYRACMNETR

ECE1

176

P42892
QYRSYFMECLVDARM

PPFIA2

1036

O75334
MCRYVRERDRLGNEY

CDC25A

441

P30304
ARTEMEMYAIYQQRR

SAMD7

96

Q7Z3H4
RVYDRRMALSECRVM

RPTOR

1191

Q8N122
QARQRREKRKEYCMY

ZC3H3

661

Q8IXZ2
SYERCRRIYNMEMAR

MRPS21

56

P82921
DNVDARMYMDRRCVY

UBA1

576

P22314
RECGKSFMYNYRLMR

ZNF548

256

Q8NEK5
QNYMVRMRLYDVNRR

VPS13D

3246

Q5THJ4