Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

FBN1 FBN2 MEGF6 MEGF8 PLA2G2D JAG1 LRP1 CBLC LTBP2 VWCE F9 FBN3 NOTCH4 LRP8

3.20e-077497114GO:0005509
GeneOntologyMolecularFunctionalpha-L-arabinofuranosidase activity

OTOGL OTOG

1.25e-052712GO:0046556
GeneOntologyMolecularFunctionextracellular matrix structural constituent

FRAS1 FBN1 FBN2 COL14A1 LTBP2 FBN3

5.54e-05188716GO:0005201
GeneOntologyMolecularFunctionaminoacyltransferase activity

RAG2 NEURL3 UBR5 DTL PEX10 CBLC RNF216 OBI1 EPB42

1.08e-04532719GO:0016755
GeneOntologyMolecularFunctioncargo receptor activity

FOLR2 LRP1 ITGB2 LRP8

2.39e-0485714GO:0038024
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

RAG2 NEURL3 UBR5 DTL PEX10 CBLC RNF216 OBI1

2.69e-04473718GO:0004842
GeneOntologyMolecularFunctionstructural molecule activity

FRAS1 FBN1 FBN2 JAG1 OBSCN COL14A1 LTBP2 FBN3 NUP153 EPB42 OTOG

2.90e-048917111GO:0005198
GeneOntologyMolecularFunctionacyltransferase activity

RAG2 NEURL3 UBR5 DTL PEX10 CBLC RNF216 GPAT2 OBI1 EPB42

3.97e-047757110GO:0016746
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RAG2 NEURL3 UBR5 DTL PEX10 CBLC RNF216 OBI1

4.56e-04512718GO:0019787
GeneOntologyMolecularFunctionphosphatidylinositol-3,4,5-trisphosphate binding

RAG2 OBSCN ASAP1

7.06e-0449713GO:0005547
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN1 FBN2

8.04e-0412712GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN1 FBN2

1.10e-0314712GO:0097493
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP1 LRP8

1.45e-0316712GO:0005041
GeneOntologyMolecularFunctionubiquitin protein ligase activity

RAG2 NEURL3 UBR5 PEX10 CBLC RNF216

2.08e-03372716GO:0061630
GeneOntologyMolecularFunctionapolipoprotein binding

LRP1 LRP8

2.27e-0320712GO:0034185
GeneOntologyMolecularFunctionfolic acid binding

FOLR2 IZUMO1R

2.27e-0320712GO:0005542
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP1 LRP8

2.51e-0321712GO:0030228
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RAG2 NEURL3 UBR5 PEX10 CBLC RNF216

2.91e-03398716GO:0061659
GeneOntologyMolecularFunctionNotch binding

JAG1 NOTCH4

4.13e-0327712GO:0005112
GeneOntologyMolecularFunctionamide binding

FOLR2 LRP1 IZUMO1R ITGB2 LRP8

4.23e-03299715GO:0033218
GeneOntologyBiologicalProcessarabinose metabolic process

OTOGL OTOG

1.20e-052722GO:0019566
GeneOntologyBiologicalProcessvibrational conductance of sound to the inner ear

OTOGL OTOG

1.20e-052722GO:0055127
GeneOntologyBiologicalProcessL-arabinose metabolic process

OTOGL OTOG

1.20e-052722GO:0046373
GeneOntologyBiologicalProcessinnate vocalization behavior

FOXP2 FOXP1

3.60e-053722GO:0098582
GeneOntologyBiologicalProcesspositive regulation of cell projection organization

MEGF8 TENM3 PLXNC1 NTRK2 TENM1 LRP1 GRN ASAP1 LRP8

5.38e-05494729GO:0031346
GeneOntologyBiologicalProcessastrocyte activation involved in immune response

LRP1 GRN

7.18e-054722GO:0002265
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

7.18e-054722GO:0035583
GeneOntologyBiologicalProcessregulation of anatomical structure morphogenesis

RNH1 MEGF8 PLXNC1 NTRK2 JAG1 LRP1 FOXP1 GRN PRAG1 ITGB2 EPB42 NOTCH4 LRP8

9.02e-0510907213GO:0022603
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

FBN1 FBN2 CRIM1 MEGF8 WFIKKN2 LRP1 KCP LTBP2

1.58e-04445728GO:0141091
GeneOntologyBiologicalProcessaorta development

MEGF8 JAG1 LRP1 NOTCH4

1.77e-0480724GO:0035904
GeneOntologyBiologicalProcessfusion of sperm to egg plasma membrane involved in single fertilization

FOLR2 TMEM95 IZUMO1R

2.06e-0433723GO:0007342
GeneOntologyBiologicalProcessresponse to growth factor

FBN1 FBN2 CRIM1 MEGF8 NTRK2 WFIKKN2 LRP1 KCP CBLC LTBP2 LRP8

2.30e-048837211GO:0070848
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

FBN1 FBN2 CRIM1 MEGF8 WFIKKN2 LRP1 KCP LTBP2

2.71e-04482728GO:0007178
GeneOntologyBiologicalProcesscell activation involved in immune response

RAG2 LRP1 MUC19 FOXP1 PHF14 GRN ITGB2

2.82e-04365727GO:0002263
GeneOntologyBiologicalProcessplasma membrane fusion

FOLR2 TMEM95 IZUMO1R

2.91e-0437723GO:0045026
GeneOntologyBiologicalProcessartery morphogenesis

MEGF8 JAG1 LRP1 NOTCH4

3.02e-0492724GO:0048844
GeneOntologyBiologicalProcesstube development

FBN1 RNH1 MEGF8 FOXP2 NTRK2 JAG1 LRP1 MUC19 FOXP1 PHF14 GRN ITGB2 ST14 NOTCH4

3.03e-0414027214GO:0035295
GeneOntologyBiologicalProcessmature B cell differentiation involved in immune response

RAG2 MUC19 PHF14

3.15e-0438723GO:0002313
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

3.32e-048722GO:0071694
GeneOntologyBiologicalProcessaorta morphogenesis

JAG1 LRP1 NOTCH4

3.95e-0441723GO:0035909
GeneOntologyBiologicalProcessmechanoreceptor differentiation

OTOGL NTRK2 JAG1 OTOG

4.82e-04104724GO:0042490
GeneOntologyBiologicalProcessregulation of mesenchymal cell proliferation

FOXP2 FOXP1 PHF14

5.21e-0445723GO:0010464
GeneOntologyBiologicalProcessmature B cell differentiation

RAG2 MUC19 PHF14

5.92e-0447723GO:0002335
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2

6.48e-0411722GO:0035581
GeneOntologyBiologicalProcessregulation of developmental growth

ATRN RAG2 MEGF8 LRP1 COL14A1 FOXP1 GRN

6.60e-04421727GO:0048638
GeneOntologyBiologicalProcesspositive regulation of axonogenesis

MEGF8 PLXNC1 NTRK2 LRP1

6.82e-04114724GO:0050772
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

MEGF8 TENM3 PLXNC1 NTRK2 TENM1 LRP1 GRN PRAG1 ASAP1 LRP8

6.84e-048467210GO:0120035
GeneOntologyBiologicalProcessB cell differentiation

RAG2 MUC19 GON4L FOXP1 PHF14

6.89e-04201725GO:0030183
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

FBN1 FBN2 CRIM1 MEGF8 NTRK2 WFIKKN2 LRP1 KCP LTBP2 LRP8

7.09e-048507210GO:0071363
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2 FBN3

1.09e-0513723GO:0001527
GeneOntologyCellularComponentextracellular matrix

FRAS1 FBN1 FBN2 MEGF6 OTOGL COL14A1 LTBP2 F9 FBN3 OTOG

8.03e-056567210GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

FRAS1 FBN1 FBN2 MEGF6 OTOGL COL14A1 LTBP2 F9 FBN3 OTOG

8.23e-056587210GO:0030312
GeneOntologyCellularComponentcerebellar climbing fiber to Purkinje cell synapse

PLXNC1 GRN

6.31e-0411722GO:0150053
DomainEGF-like_dom

ATRN FRAS1 FBN1 FBN2 MEGF6 MEGF8 TENM3 JAG1 TENM1 LRP1 ADAM29 LTBP2 C7 VWCE F9 FBN3 NOTCH4 OTOG LRP8

3.02e-202496919IPR000742
DomainEGF_3

ATRN FBN1 FBN2 MEGF6 MEGF8 TENM3 JAG1 TENM1 LRP1 ADAM29 LTBP2 C7 VWCE F9 FBN3 NOTCH4 OTOG LRP8

3.16e-192356918PS50026
DomainEGF_1

ATRN FBN1 FBN2 MEGF6 MEGF8 TENM3 JAG1 TENM1 LRP1 ADAM29 LTBP2 C7 VWCE ITGB2 F9 FBN3 NOTCH4 LRP8

1.38e-182556918PS00022
DomainEGF-like_CS

ATRN FBN1 FBN2 MEGF6 MEGF8 TENM3 JAG1 TENM1 LRP1 ADAM29 LTBP2 C7 VWCE ITGB2 F9 FBN3 NOTCH4 LRP8

2.09e-182616918IPR013032
DomainEGF_2

ATRN FBN1 FBN2 MEGF6 MEGF8 TENM3 JAG1 TENM1 LRP1 ADAM29 LTBP2 C7 VWCE ITGB2 F9 FBN3 NOTCH4 LRP8

2.75e-182656918PS01186
DomainEGF

ATRN FRAS1 FBN1 FBN2 MEGF6 MEGF8 TENM3 JAG1 TENM1 LRP1 LTBP2 VWCE F9 FBN3 NOTCH4 LRP8

2.50e-162356916SM00181
DomainGrowth_fac_rcpt_

ATRN FRAS1 FBN1 FBN2 CRIM1 MEGF6 MEGF8 JAG1 LRP1 LTBP2 VWCE FBN3 NOTCH4 LRP8

4.63e-161566914IPR009030
DomainEGF_Ca-bd_CS

FBN1 FBN2 MEGF6 MEGF8 JAG1 LRP1 LTBP2 VWCE F9 FBN3 NOTCH4 LRP8

1.32e-15976912IPR018097
DomainEGF_CA

FBN1 FBN2 MEGF6 MEGF8 JAG1 LRP1 LTBP2 VWCE F9 FBN3 NOTCH4 LRP8

1.70e-15996912PS01187
DomainASX_HYDROXYL

FBN1 FBN2 MEGF6 MEGF8 JAG1 LRP1 LTBP2 VWCE F9 FBN3 NOTCH4 LRP8

1.93e-151006912PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FBN1 FBN2 MEGF6 MEGF8 JAG1 LRP1 LTBP2 VWCE F9 FBN3 NOTCH4 LRP8

3.97e-151066912IPR000152
DomainEGF_CA

FBN1 FBN2 MEGF6 MEGF8 JAG1 LRP1 LTBP2 VWCE FBN3 NOTCH4 LRP8

1.49e-14866911PF07645
DomainEGF_CA

FBN1 FBN2 MEGF6 MEGF8 JAG1 LRP1 LTBP2 VWCE F9 FBN3 NOTCH4 LRP8

2.24e-141226912SM00179
DomainEGF-like_Ca-bd_dom

FBN1 FBN2 MEGF6 MEGF8 JAG1 LRP1 LTBP2 VWCE F9 FBN3 NOTCH4 LRP8

2.73e-141246912IPR001881
DomainVWC_out

FRAS1 CRIM1 JAG1 MUC19 KCP VWCE OTOG

3.34e-1319697SM00215
DomainVWF_dom

FRAS1 CRIM1 JAG1 MUC19 KCP VWCE OTOG

1.67e-1042697IPR001007
DomainEGF

ATRN MEGF6 JAG1 LRP1 LTBP2 F9 FBN3 NOTCH4 LRP8

8.74e-10126699PF00008
DomainEGF_extracell

ATRN MEGF6 TENM3 JAG1 TENM1 LTBP2 ITGB2

2.27e-0960697IPR013111
DomainEGF_2

ATRN MEGF6 TENM3 JAG1 TENM1 LTBP2 ITGB2

2.27e-0960697PF07974
DomainVWC

FRAS1 CRIM1 JAG1 MUC19 KCP VWCE

5.12e-0938696SM00214
DomainTB

FBN1 FBN2 LTBP2 FBN3

5.92e-097694PF00683
Domain-

FBN1 FBN2 LTBP2 FBN3

1.18e-0886943.90.290.10
DomainTB

FBN1 FBN2 LTBP2 FBN3

2.12e-089694PS51364
DomainTB_dom

FBN1 FBN2 LTBP2 FBN3

2.12e-089694IPR017878
DomainFBN

FBN1 FBN2 FBN3

4.83e-083693IPR011398
DomainhEGF

FBN2 MEGF6 JAG1 FBN3 NOTCH4

5.46e-0828695PF12661
DomainVWFC_2

FRAS1 CRIM1 MUC19 KCP VWCE

2.71e-0738695PS50184
DomaincEGF

FBN1 FBN2 LRP1 FBN3

2.40e-0626694IPR026823
DomaincEGF

FBN1 FBN2 LRP1 FBN3

2.40e-0626694PF12662
DomainVWC

FRAS1 CRIM1 KCP VWCE

3.27e-0628694PF00093
DomainVWFC_1

FRAS1 CRIM1 KCP VWCE

9.19e-0636694PS01208
Domain-

TENM3 TENM1 LRP1 LRP8

1.27e-05396942.120.10.30
DomainUnchr_dom_Cys-rich

MUC19 KCP OTOG

1.34e-0513693IPR014853
DomainC8

MUC19 KCP OTOG

1.34e-0513693SM00832
DomainLDLR_class-A_CS

LRP1 C7 ST14 LRP8

1.41e-0540694IPR023415
DomainTIL_dom

MUC19 KCP OTOG

1.71e-0514693IPR002919
DomainPSI

ATRN MEGF8 PLXNC1 ITGB2

2.07e-0544694IPR016201
DomainLdl_recept_a

LRP1 C7 ST14 LRP8

2.27e-0545694PF00057
DomainPSI

ATRN MEGF8 PLXNC1 ITGB2

2.48e-0546694SM00423
Domain-

LRP1 C7 ST14 LRP8

2.48e-05466944.10.400.10
Domain6-blade_b-propeller_TolB-like

TENM3 TENM1 LRP1 LRP8

2.48e-0546694IPR011042
DomainVWD

MUC19 KCP OTOG

2.61e-0516693SM00216
DomainVWF_type-D

MUC19 KCP OTOG

2.61e-0516693IPR001846
DomainVWFD

MUC19 KCP OTOG

2.61e-0516693PS51233
DomainVWD

MUC19 KCP OTOG

2.61e-0516693PF00094
DomainLDLRA_1

LRP1 C7 ST14 LRP8

2.94e-0548694PS01209
DomainLDLRA_2

LRP1 C7 ST14 LRP8

3.19e-0549694PS50068
DomainLDrepeatLR_classA_rpt

LRP1 C7 ST14 LRP8

3.19e-0549694IPR002172
DomainLDLa

LRP1 C7 ST14 LRP8

3.19e-0549694SM00192
DomainTox-GHH_dom

TENM3 TENM1

8.03e-054692IPR028916
DomainTen_N

TENM3 TENM1

8.03e-054692IPR009471
DomainFOXP-CC

FOXP2 FOXP1

8.03e-054692PF16159
DomainTen_N

TENM3 TENM1

8.03e-054692PF06484
DomainFOXP-CC

FOXP2 FOXP1

8.03e-054692IPR032354
DomainTENEURIN_N

TENM3 TENM1

8.03e-054692PS51361
DomainTox-GHH

TENM3 TENM1

8.03e-054692PF15636
DomainFolate_rcpt

FOLR2 IZUMO1R

1.34e-045692IPR004269
DomainYD

TENM3 TENM1

1.34e-045692IPR006530
DomainPSI

ATRN MEGF8 PLXNC1

2.22e-0432693PF01437
DomainPlexin_repeat

ATRN MEGF8 PLXNC1

2.22e-0432693IPR002165
DomainLaminin_EGF

ATRN MEGF6 MEGF8

2.90e-0435693PF00053
DomainEGF_Lam

ATRN MEGF6 MEGF8

2.90e-0435693SM00180
DomainLaminin_EGF

ATRN MEGF6 MEGF8

3.71e-0438693IPR002049
DomainFolate_rcpt-like

FOLR2 IZUMO1R

3.71e-048692IPR018143
DomainFolate_rec

FOLR2 IZUMO1R

3.71e-048692PF03024
DomainIntegin_beta_N

MEGF8 ITGB2

4.76e-049692IPR033760
DomainPSI_integrin

MEGF8 ITGB2

4.76e-049692PF17205
Domain-

ATRN RAG2 MEGF8

7.41e-04486932.120.10.80
DomainCUB

ATRN MEGF8 ST14

7.87e-0449693PF00431
DomainCUB

ATRN MEGF8 ST14

8.35e-0450693SM00042
DomainTIL

MUC19 OTOG

8.67e-0412692PF01826
DomainC8

MUC19 OTOG

8.67e-0412692PF08742
Domain-

ATRN MEGF8 ST14

9.37e-04526932.60.120.290
DomainCUB

ATRN MEGF8 ST14

9.90e-0453693PS01180
DomainNHL

TENM3 TENM1

1.02e-0313692PS51125
DomainKelch-typ_b-propeller

ATRN RAG2 MEGF8

1.10e-0355693IPR015915
DomainLdl_recept_b

LRP1 LRP8

1.19e-0314692PF00058
DomainLDLRB

LRP1 LRP8

1.19e-0314692PS51120
DomainCUB_dom

ATRN MEGF8 ST14

1.22e-0357693IPR000859
DomainGal_Oxase/kelch_b-propeller

ATRN RAG2 MEGF8

1.35e-0359693IPR011043
DomainLY

LRP1 LRP8

1.37e-0315692SM00135
DomainLDLR_classB_rpt

LRP1 LRP8

1.37e-0315692IPR000033
DomainCT

MUC19 OTOG

2.96e-0322692SM00041
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN2 LTBP2 FBN3

2.29e-0625544M39713
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 FBN2 LTBP2 FBN3

1.16e-0537544M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 FBN2 LTBP2 FBN3

2.33e-0544544M26969
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 FBN2 LTBP2

2.44e-0432543MM14854
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

FBN1 FBN2 MEGF6 COL14A1 LTBP2 ITGB2

4.39e-04258546MM14572
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 FBN2 LTBP2

4.40e-0439543MM14601
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBN1 FBN2 MEGF6 JAG1

2.23e-09973412122015
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN2 FBN3

3.54e-08473325034023
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

FBN1 CRIM1 MEGF6 MEGF8 LRP1 GRN

1.90e-0711873621078624
Pubmed

TBX1 is required for normal stria vascularis and semicircular canal development.

ATRN FBN1 GRN OTOG

5.38e-073173431550482
Pubmed

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.

TENM3 PLXNC1 NTRK2 TENM1 LRP8

1.43e-069173528558017
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

FBN1 FBN2 CRIM1 UBR5 LRP1 GRN

2.56e-0618473632908313
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

4.35e-06273212399449
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

4.35e-06273221851253
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

4.35e-06273212429739
Pubmed

Differential and Overlapping Pattern of Foxp1 and Foxp2 Expression in the Striatum of Adult Mouse Brain.

FOXP2 FOXP1

4.35e-06273230031127
Pubmed

JAG1-NOTCH4 mechanosensing drives atherosclerosis.

JAG1 NOTCH4

4.35e-06273236044575
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

4.35e-06273230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

4.35e-06273221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

4.35e-06273215131124
Pubmed

Foxp2 regulates anatomical features that may be relevant for vocal behaviors and bipedal locomotion.

FOXP2 FOXP1

4.35e-06273230104377
Pubmed

LDL-receptor-related protein regulates beta2-integrin-mediated leukocyte adhesion.

LRP1 ITGB2

4.35e-06273215328156
Pubmed

Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.

LRP1 LRP8

4.35e-06273212871934
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

4.35e-06273212524050
Pubmed

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.

JAG1 NOTCH4

4.35e-06273226387946
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

4.35e-06273220404337
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

4.35e-0627328791520
Pubmed

Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development.

NTRK2 JAG1

4.35e-06273222028443
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

4.35e-0627328120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

4.35e-06273235419902
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

4.35e-0627328307578
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

4.35e-06273210504303
Pubmed

Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.

FBN1 FBN3

4.35e-06273215221638
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

4.35e-0627327744963
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

4.35e-06273226408953
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

4.35e-06273218006876
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

4.35e-06273224833718
Pubmed

Exome sequencing identified new mutations in a Marfan syndrome family.

FBN1 LRP1

4.35e-06273224484584
Pubmed

Investigating protein-protein interactions in live cells using bioluminescence resonance energy transfer.

FOXP2 FOXP1

4.35e-06273224893771
Pubmed

Foxp1 is an essential transcriptional regulator of B cell development.

RAG2 FOXP1

4.35e-06273216819554
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

4.35e-06273224265020
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

4.35e-06273220529844
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

4.35e-06273225524144
Pubmed

B-cell deficiency does not abrogate development of cutaneous hyperplasia in mice inheriting the defective fibrillin-1 gene.

RAG2 FBN1

4.35e-0627329451590
Pubmed

Residues Phe342-Asn346 of activated coagulation factor IX contribute to the interaction with low density lipoprotein receptor-related protein.

LRP1 F9

4.35e-06273212522212
Pubmed

Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction.

FOXP2 FOXP1

4.35e-06273215056695
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

4.35e-06273223133647
Pubmed

Similar phenotypes caused by mutations in OTOG and OTOGL.

OTOGL OTOG

4.35e-06273224378291
Pubmed

A de novo FOXP1 variant in a patient with autism, intellectual disability and severe speech and language impairment.

FOXP2 FOXP1

4.35e-06273225853299
Pubmed

FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures.

FOXP2 FOXP1

4.35e-06273227224915
Pubmed

Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors.

FOXP2 FOXP1

4.35e-06273211358962
Pubmed

Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix.

FBN1 LTBP2

4.35e-06273224867584
Pubmed

Equivalent missense variant in the FOXP2 and FOXP1 transcription factors causes distinct neurodevelopmental disorders.

FOXP2 FOXP1

4.35e-06273228741757
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

4.35e-06273216407178
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

4.35e-0627321852206
Pubmed

Compensation between FOXP transcription factors maintains proper striatal function.

FOXP2 FOXP1

4.35e-06273238761373
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

4.35e-06273210359653
Pubmed

ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.

ASAP3 ASAP1

4.35e-06273218400762
Pubmed

The mouse tight skin (Tsk) phenotype is not dependent on the presence of mature T and B lymphocytes.

RAG2 FBN1

4.35e-0627329799844
Pubmed

Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder.

FOXP2 FOXP1

4.35e-06273226647308
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ATRN FRAS1 FBN1 FBN2 ERO1B CRIM1 MEGF8 TENM3 LRP1 GRN LTBP2 LRP8

7.16e-061201731235696571
Pubmed

Hematopoietic stem/progenitor cells directly contribute to arteriosclerotic progression via integrin β2.

LRP1 ITGB2

1.30e-05373225546260
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

1.30e-05373210825173
Pubmed

Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues.

FOXP2 FOXP1

1.30e-05373214516685
Pubmed

Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.

LRP1 LRP8

1.30e-05373224251389
Pubmed

Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma.

JAG1 NOTCH4

1.30e-05373226341090
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

FBN1 FBN2

1.30e-05373230201140
Pubmed

Human-specific transcriptional regulation of CNS development genes by FOXP2.

FOXP2 FOXP1

1.30e-05373219907493
Pubmed

Establishment of tumor-associated immunity requires interaction of heat shock proteins with CD91.

RAG2 LRP1

1.30e-05373224778318
Pubmed

Molecular basis for the interaction of low density lipoprotein receptor-related protein 1 (LRP1) with integrin alphaMbeta2: identification of binding sites within alphaMbeta2 for LRP1.

LRP1 ITGB2

1.30e-05373221676865
Pubmed

Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen.

FOLR2 ITGB2

1.30e-05373227534550
Pubmed

Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation.

JAG1 NOTCH4

1.30e-05373214988227
Pubmed

Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes, VLDLR and CNTNAP2 in the Zebra Finch Song System.

FOXP2 FOXP1

1.30e-05373228507505
Pubmed

Selective reprogramming of regulatory T cells in solid tumors can strongly enhance or inhibit tumor growth.

FOLR2 IZUMO1R

1.30e-05373237928524
Pubmed

Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation.

JAG1 NOTCH4

1.30e-05373215939383
Pubmed

Magnesium sensing via LFA-1 regulates CD8+ T cell effector function.

RAG2 ITGB2

1.30e-05373235051368
Pubmed

Low density lipoprotein receptor-related protein and factor IXa share structural requirements for binding to the A3 domain of coagulation factor VIII.

LRP1 F9

1.30e-05373212522143
Pubmed

Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain.

FOXP2 FOXP1

1.30e-05373212687690
Pubmed

LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.

FBN1 LTBP2

1.30e-05373217293099
Pubmed

Transcriptional regulation by FOXP1, FOXP2, and FOXP4 dimerization.

FOXP2 FOXP1

1.30e-05373225027557
Pubmed

Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.

LRP1 LRP8

1.30e-05373212807892
Pubmed

Foxp1 expression is essential for sex-specific murine neonatal ultrasonic vocalization.

FOXP2 FOXP1

1.30e-05373228204507
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

FBN1 FBN2

1.30e-05373220855508
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

ATRN MEGF8 NTRK2 LRP1 C7 ITGB2

1.73e-0525773616335952
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

FBN1 FBN2 JAG1

2.23e-052673334189436
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FRAS1 MEGF8 TENM3 UBR5 GON4L ARRDC3 ASAP1

2.39e-0540773712693553
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 FBN2

2.60e-05473212429738
Pubmed

Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions.

FOXP2 FOXP1

2.60e-05473214701752
Pubmed

Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.

TENM3 TENM1

2.60e-05473210225957
Pubmed

Human eye development is characterized by coordinated expression of fibrillin isoforms.

FBN1 FBN2

2.60e-05473225406291
Pubmed

Comparative immunolocalization of the elastin fiber-associated proteins fibrillin-1, LTBP-2, and MAGP-1 with components of the collagenous and proteoglycan matrix of the fetal human intervertebral disc.

FBN1 LTBP2

2.60e-05473221540769
Pubmed

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

FBN1 FBN2

2.60e-05473220729550
Pubmed

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

JAG1 NOTCH4

2.60e-05473217984306
Pubmed

Identification of two putative novel folate receptor genes in humans and mouse.

FOLR2 IZUMO1R

2.60e-05473211111049
Pubmed

Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.

FBN1 FBN2

2.60e-05473216835936
Pubmed

Weill-Marchesani Syndrome

FBN1 LTBP2

2.60e-05473220301293
Pubmed

Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties.

JAG1 NOTCH4

2.60e-05473236376768
Pubmed

Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs.

FOXP2 FOXP1

2.60e-05473233525513
Pubmed

Identification and characterization of T reg-like cells in zebrafish.

FOXP2 FOXP1

2.60e-05473229066577
Pubmed

Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides.

LRP1 ITGB2

2.60e-05473220199584
Pubmed

FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression.

JAG1 FOXP1

2.60e-05473229141232
Pubmed

All four members of the Ten-m/Odz family of transmembrane proteins form dimers.

TENM3 TENM1

2.60e-05473212000766
Pubmed

Autologous and Heterologous Cell Therapy for Hemophilia B toward Functional Restoration of Factor IX.

RAG2 F9

2.60e-05473229719266
Pubmed

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.

TENM3 NTRK2 FOXP1 LRP8

2.76e-058273431073041
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

FBN1 FBN2 COL14A1 LTBP2

3.33e-058673428327460
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

FBN1 FBN2 MEGF6 COL14A1 LTBP2

3.47e-0517573528071719
InteractionFBXO2 interactions

ATRN FRAS1 FBN1 FBN2 ERO1B MEGF8 TENM3 PLXNC1 JAG1 COL14A1 GRN ST14

1.61e-084117012int:FBXO2
InteractionZNF408 interactions

ATRN FRAS1 FBN1 FBN2 GRN LTBP2 VWCE

7.08e-07145707int:ZNF408
InteractionMFAP5 interactions

FBN1 FBN2 MEGF6 JAG1 GRN

1.00e-0652705int:MFAP5
InteractionZFP41 interactions

FRAS1 FBN1 FBN2 LRP1 GRN

1.59e-0657705int:ZFP41
InteractionFBN2 interactions

FBN1 FBN2 LTBP2 VWCE ST14

3.07e-0665705int:FBN2
InteractionIGFL3 interactions

ATRN FRAS1 FBN2 UBR5 GRN

6.25e-0675705int:IGFL3
InteractionMFAP2 interactions

FBN1 FBN2 JAG1

8.63e-0612703int:MFAP2
InteractionZNF444 interactions

FRAS1 RNH1 LTBP2 VWCE ZNF446

3.38e-05106705int:ZNF444
InteractionATXN7 interactions

FBN1 CRIM1 MEGF6 MEGF8 GRN

3.86e-05109705int:ATXN7
InteractionLYZL1 interactions

ATRN FRAS1 ERO1B UBR5 ST14

5.65e-05118705int:LYZL1
InteractionCACNA1A interactions

CRIM1 MEGF6 MEGF8 LRP1 GRN

6.88e-05123705int:CACNA1A
InteractionNTN5 interactions

FRAS1 FBN1 FBN2

7.71e-0524703int:NTN5
InteractionST14 interactions

ATRN FBN1 FBN2 ERO1B CRIM1 ST14

8.29e-05207706int:ST14
InteractionZSCAN21 interactions

FRAS1 GRN LTBP2 VWCE ZNF446

8.31e-05128705int:ZSCAN21
InteractionCTU1 interactions

CIAO1 GRN CHIT1 VWCE

1.42e-0476704int:CTU1
InteractionSLURP1 interactions

ATRN ERO1B MEGF8 GRN ST14

1.45e-04144705int:SLURP1
InteractionEGFL7 interactions

GRN VWCE ST14 NOTCH4

1.49e-0477704int:EGFL7
InteractionZNF664 interactions

LTBP2 VWCE ST14

1.68e-0431703int:ZNF664
InteractionPRELP interactions

FRAS1 MEGF8 COL14A1

1.85e-0432703int:PRELP
GeneFamilyLow density lipoprotein receptors

LRP1 LRP8

4.85e-0413462634
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

ASAP3 ASAP1

8.41e-04174621291
GeneFamilyArfGAPs

ASAP3 ASAP1

3.18e-0333462395
GeneFamilyComplement system|Sushi domain containing

C7 ITGB2

3.78e-0336462492
GeneFamilyRing finger proteins

PEX10 CBLC RNF216 OBI1

5.18e-0327546458
GeneFamilyForkhead boxes

FOXP2 FOXP1

5.35e-0343462508
CoexpressionNABA_MATRISOME

FRAS1 FBN1 FBN2 CRIM1 MEGF6 MEGF8 OTOGL PLXNC1 WFIKKN2 MUC19 KCP COL14A1 ADAM29 LTBP2 VWCE F9 ST14 OTOG

1.70e-1010087218MM17056
CoexpressionNABA_MATRISOME

FRAS1 FBN1 FBN2 CRIM1 MEGF6 MEGF8 PLXNC1 WFIKKN2 MUC19 KCP COL14A1 ADAM29 LTBP2 VWCE F9 ST14 FBN3 OTOG

2.26e-1010267218M5889
CoexpressionNABA_ECM_GLYCOPROTEINS

FRAS1 FBN1 FBN2 CRIM1 OTOGL KCP LTBP2 VWCE OTOG

2.75e-09191729MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

FRAS1 FBN1 FBN2 CRIM1 KCP LTBP2 VWCE FBN3 OTOG

3.45e-09196729M3008
CoexpressionNABA_CORE_MATRISOME

FRAS1 FBN1 FBN2 CRIM1 OTOGL KCP COL14A1 LTBP2 VWCE OTOG

3.48e-092707210MM17057
CoexpressionNABA_CORE_MATRISOME

FRAS1 FBN1 FBN2 CRIM1 KCP COL14A1 LTBP2 VWCE FBN3 OTOG

4.15e-092757210M5884
CoexpressionBOQUEST_STEM_CELL_UP

FBN1 NTRK2 TENM1 LRP1 COL14A1 LTBP2 C7

7.60e-06261727M1834
CoexpressionRODWELL_AGING_KIDNEY_UP

TNFRSF25 FBN1 COL14A1 GRN C7 VWCE PRAG1 ITGB2 ASAP1

9.27e-06501729M5389
CoexpressionGSE2405_HEAT_KILLED_LYSATE_VS_LIVE_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_24H_UP

RNH1 WFIKKN2 LRP1 RNF216 GRN ST14

1.88e-05200726M6200
CoexpressionDESCARTES_FETAL_THYMUS_STROMAL_CELLS

FBN1 FBN2 NTRK2 LRP1 COL14A1

3.83e-05137725M40313
CoexpressionBROWNE_HCMV_INFECTION_30MIN_DN

RAG2 GRM5 ITGB2 EPB42 LRP8

5.02e-05145725M0
CoexpressionBROWNE_HCMV_INFECTION_48HR_DN

RAG2 RNH1 PLXNC1 FOLR2 NTRK2 LTBP2 ITGB2 EPB42

5.27e-05482728M12144
CoexpressionDESERT_PERIPORTAL_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP

ATRN ERO1B TENM1 C7 F9

7.78e-05159725M34031
CoexpressionMCBRYAN_PUBERTAL_TGFB1_TARGETS_UP

CRIM1 JAG1 FOXP1 ST14 NOTCH4

1.01e-04168725M1124
CoexpressionJONES_OVARY_NK_CELL

FBN1 CRIM1 COL14A1 NOTCH4

1.07e-0489724M48353
CoexpressionGSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP

PLXNC1 CIAO1 RLN3 RNF216 GRN

1.19e-04174725M333
CoexpressionRUBENSTEIN_SKELETAL_MUSCLE_FBN1_FAP_CELLS

FBN1 RNH1 NTRK2 JAG1 LRP1 COL14A1

1.45e-04289726M41750
CoexpressionMCBRYAN_PUBERTAL_TGFB1_TARGETS_UP

CRIM1 JAG1 FOXP1 ST14 NOTCH4

1.47e-04182725MM993
CoexpressionLAKE_ADULT_KIDNEY_C25_ENDOTHELIAL_CELLS_UNASSIGNED

FOXP2 FOXP1 ASAP1

1.56e-0438723M39244
CoexpressionGSE1460_DP_THYMOCYTE_VS_NAIVE_CD4_TCELL_ADULT_BLOOD_DN

TNFRSF25 MEGF6 ASAP3 CHIT1 ITGB2

2.12e-04197725M3465
CoexpressionGSE29618_BCELL_VS_PDC_DAY7_FLU_VACCINE_DN

CRIM1 JAG1 GRN ST14 NOTCH4

2.17e-04198725M4959
CoexpressionGSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_12H_UP

UTP4 LRP1 COL14A1 ARRDC3 EPB42

2.27e-04200725M6418
CoexpressionGSE369_PRE_VS_POST_IL6_INJECTION_SOCS3_KO_LIVER_DN

ATRN MEGF8 PLXNC1 FOLR2 GRN

2.27e-04200725M5977
CoexpressionGSE12392_WT_VS_IFNAR_KO_CD8A_NEG_SPLEEN_DC_UP

SIGLEC10 NELFB LRP1 ST14 LRP8

2.27e-04200725M7147
CoexpressionGSE15735_2H_VS_12H_HDAC_INHIBITOR_TREATED_CD4_TCELL_UP

TNFRSF25 RNF216 IZUMO1R NUP153 ASAP1

2.27e-04200725M7159
CoexpressionGSE6092_UNSTIM_VS_IFNG_STIM_AND_B_BURGDORFERI_INF_ENDOTHELIAL_CELL_DN

FBN1 DHX38 KCP THSD7B NOTCH4

2.27e-04200725M6715
CoexpressionGSE20198_UNTREATED_VS_IL12_IL18_TREATED_ACT_CD4_TCELL_DN

UBR5 UTP4 KCP GRN ZNF446

2.27e-04200725M7373
CoexpressionHAY_BONE_MARROW_STROMAL

FBN1 CRIM1 OTOGL NTRK2 JAG1 COL14A1 LTBP2 C7 THSD7B

2.46e-04767729M39209
CoexpressionCUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL

FBN1 LRP1 COL14A1 C7

3.07e-04117724M39300
CoexpressionVERHAAK_GLIOBLASTOMA_MESENCHYMAL

FOLR2 GRN LTBP2 ITGB2 ST14

3.24e-04216725M2122
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

MEGF6 COL14A1 LTBP2 C7 THSD7B PRAG1 NOTCH4

2.33e-08188727c90669b51e1902fe7726555290c91c92a911df83
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FBN1 FBN2 OTOGL NTRK2 MUC19 COL14A1 THSD7B

2.99e-08195727d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FBN1 FBN2 OTOGL NTRK2 MUC19 COL14A1 THSD7B

2.99e-0819572719853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCelldistal-Hematologic-Interstitial_Macrophage|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLA2G2D PLXNC1 FOLR2 SIGLEC10 GRN CHIT1 ITGB2

3.32e-08198727a35b43d38e18c6f8f0cd9015b8e23f71c729f023
ToppCellControl-Myeloid-MoAM2,_CCL18|Control / Condition, Lineage and Cell class

PLA2G2D PLXNC1 FOLR2 LTBP2 CHIT1 ST14

3.88e-071747264c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLXNC1 FOLR2 SIGLEC10 LRP1 GRN ITGB2

4.29e-07177726382f0d6bbff01e84b0c7840e74ac865864e6da89
ToppCellControl-Myeloid-MoAM2,_CCL18|Myeloid / Condition, Lineage and Cell class

PLA2G2D PLXNC1 FOLR2 LTBP2 CHIT1 ST14

4.29e-07177726470f54fe2b21c7350ea471e02039461a3808f700
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 FBN2 OTOGL OBSCN TENM1 OTOG

5.38e-071847262cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 FBN2 OTOGL OBSCN TENM1 OTOG

5.38e-07184726ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 FBN2 OTOGL OBSCN TENM1 OTOG

5.38e-071847262b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 NTRK2 LRP1 COL14A1 C7

5.56e-07185726785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 NTRK2 LRP1 COL14A1 C7

5.56e-0718572697a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 NTRK2 LRP1 COL14A1 C7

5.74e-0718672694d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FBN1 FBN2 TENM3 FOXP2 NTRK2 VWCE

5.74e-071867264d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLA2G2D PLXNC1 FOLR2 GRN CHIT1 ITGB2

6.11e-07188726fcf1bebef7aa81b4a11c1f9e4319339c290ecd22
ToppCellASK454-Mesenchymal|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

FRAS1 FBN1 TENM1 COL14A1 LTBP2 C7

6.70e-07191726e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCellASK454-Mesenchymal-Fibroblast|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

FRAS1 FBN1 TENM1 COL14A1 LTBP2 C7

6.70e-071917261726add3f392a061536b7aff72ba84303f4a0b1f
ToppCellMacrophages-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

PLXNC1 SIGLEC10 LRP1 GRN CHIT1 ITGB2

7.56e-07195726eb104f3bb08ab9eca31273c0523a5c90de1f30a9
ToppCelldistal-Hematologic-Interstitial_Macrophage-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLA2G2D PLXNC1 FOLR2 SIGLEC10 CHIT1 ITGB2

7.79e-07196726e4f40274df940e0996c555082f2bb4f99e5b0881
ToppCellCOVID-19-lung-Fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBN1 TENM3 LRP1 COL14A1 LTBP2 C7

8.26e-071987263ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 MEGF6 TENM3 JAG1 COL14A1 C7

8.26e-071987269541d68a1a6247dbd7161a62644eea6527c2c8ff
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

FRAS1 FBN1 TENM3 COL14A1 LTBP2 C7

8.26e-07198726df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellcellseq2-Immune-Immune_Myeloid-IM-IM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PLXNC1 FOLR2 SIGLEC10 LRP1 GRN ITGB2

8.51e-07199726372fb9eb90022dc4ac770a75b4e207c33d1d0c43
ToppCellcellseq2-Immune-Immune_Myeloid-IM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PLXNC1 FOLR2 SIGLEC10 LRP1 GRN ITGB2

8.51e-07199726dd3bf59cdc18091889cbf6c43f37100ba537843d
ToppCellcellseq2-Immune-Immune_Myeloid|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PLXNC1 FOLR2 SIGLEC10 LRP1 GRN ITGB2

8.51e-071997266c3c9eceea20121ae17ae2462134aa0437f591b3
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PLA2G2D PLXNC1 FOLR2 SIGLEC10 CHIT1 ITGB2

8.51e-07199726368e2bafae00ce8e9c6ea480f81b78f96b680acd
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 TENM3 LRP1 COL14A1 LTBP2 C7

8.76e-07200726389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FRAS1 FBN1 TENM3 LRP1 LTBP2 C7

8.76e-07200726e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 TENM1 LRP1 COL14A1 LTBP2 C7

8.76e-07200726b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 TENM3 LRP1 COL14A1 LTBP2 C7

8.76e-07200726cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 TENM3 LRP1 COL14A1 LTBP2 C7

8.76e-07200726cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

FBN2 TENM3 TENM1 KCP THSD7B LRP8

8.76e-07200726107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 TENM3 LRP1 COL14A1 LTBP2 C7

8.76e-07200726311fab076f2ceb258e3970eb21e39344b894042a
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FRAS1 FBN1 TENM3 LRP1 LTBP2 C7

8.76e-0720072634f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellTracheal-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 NTRK2 LRP1 COL14A1 LTBP2 C7

8.76e-07200726920e6036c0a9c0089d0d898673daf9dd9d7279fc
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 FBN2 FOXP2 MUC19 KCP

6.17e-06160725c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 FBN2 FOXP2 MUC19 KCP

6.17e-0616072525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCelldroplet-Thymus-nan-21m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAQR9 PLA2G2D FOLR2 OBSCN GRN

6.36e-06161725441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 LRP1 COL14A1 LTBP2 C7

7.82e-061687254b2d29a7843bf45922038c093ca7ec0600756adc
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NEURL3 MEGF6 JAG1 OBSCN FOXP1

8.28e-06170725af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 LRP1 COL14A1 LTBP2 C7

8.52e-061717255d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRAS1 CRIM1 MEGF6 TENM3 COL14A1

9.01e-0617372530d67738633493d47f06ae452424382f069b6c0a
ToppCellBAL-Mild-Myeloid-MoAM-MoAM4-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NEURL3 PLXNC1 KCP CHIT1 EPB42

9.27e-06174725fe105550a43b935affc73e32796115d20328a2f8
ToppCellBAL-Mild-Myeloid-MoAM-MoAM4|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

NEURL3 PLXNC1 KCP CHIT1 EPB42

9.27e-061747259191f6abb37ca65da5105f91e21689d11ec1059b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 LRP1 COL14A1 LTBP2 C7

9.53e-06175725795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCellBAL-Mild-Myeloid-MoAM-MoAM4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NEURL3 PLXNC1 KCP CHIT1 EPB42

9.53e-06175725b2099b4ab1bf74497f454a99fffe5f5561b1f968
ToppCellBAL-Mild-Myeloid-MoAM-MoAM4-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NEURL3 PLXNC1 KCP CHIT1 EPB42

9.53e-061757256e54b74c735f249c7bfab7087c1638065ec1dd2e
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

USP49 FBN1 TENM3 NTRK2 JAG1

1.01e-0517772530f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCellBAL-Control-Myeloid-Macrophage|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLA2G2D PLXNC1 FOLR2 KCP CHIT1

1.18e-051837258e9d45c96b44558158e3d59613f64a73d5390c19
ToppCellBAL-Control-Myeloid-Macrophage-transitional_Macro-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLA2G2D PLXNC1 FOLR2 KCP CHIT1

1.18e-051837250408d991ddb639594b45d5cb2432dd29289167b1
ToppCellBAL-Control-Myeloid-Macrophage-transitional_Macro|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLA2G2D PLXNC1 FOLR2 KCP CHIT1

1.18e-0518372579f05b8a967124d831b0baef137e30659f5917a7
ToppCellBAL-Control-Myeloid-Macrophage-transitional_Macro-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PLA2G2D PLXNC1 FOLR2 KCP CHIT1

1.21e-0518472592202e1cd0bba1ce4b061ebcb8a2af5bb590542a
ToppCellBAL-Control-Myeloid-Macrophage|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PLA2G2D PLXNC1 FOLR2 KCP CHIT1

1.21e-051847257331535d469453a5264dcb0270a97f63d3b55201
ToppCellBAL-Control-Myeloid-Macrophage-transitional_Macro|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PLA2G2D PLXNC1 FOLR2 KCP CHIT1

1.21e-05184725337e38a6b2b6770cc992d88b006829f194841b10
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FBN1 FBN2 TENM3 NTRK2 LTBP2

1.25e-051857257dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellmetastatic_Lymph_Node-Fibroblasts-COL14A1+_matrix_FBs|metastatic_Lymph_Node / Location, Cell class and cell subclass

FBN1 WFIKKN2 COL14A1 LTBP2 C7

1.25e-05185725506eee2c1b6e8acec3aa8b2c66868010006c4c14
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBN1 FOXP2 LRP1 LTBP2 C7

1.25e-051857258f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBN1 TENM3 NTRK2 LRP1 COL14A1

1.25e-05185725c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBN2 TENM3 TENM1 KCP LRP8

1.28e-0518672596f6603cc75fa1ffc2a2fdb94ec0ec09498e540a
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FBN1 FBN2 TENM3 NTRK2 LTBP2

1.31e-051877255258674d0346e5c51a4b965efcdc1790c970845d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBN2 TENM3 TENM1 KCP LRP8

1.31e-0518772585f1678338a47d91e296f0620d4887f057eb7e70
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

FRAS1 FBN1 TENM3 LTBP2 C7

1.31e-0518772592d468dde81125d51daf7abd4703741abe1ab91c
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 MEGF6 JAG1 THSD7B NOTCH4

1.31e-05187725e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBN1 FOXP2 LRP1 LTBP2 C7

1.35e-05188725fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCellMesenchymal-chondrocyte|World / Lineage, Cell type, age group and donor

FBN1 FBN2 TENM3 NTRK2 WFIKKN2

1.35e-051887257b1e3f8a941eaa68e89c562129a92314642eec66
ToppCellFibroblast-C|World / shred on cell class and cell subclass (v4)

FBN1 FBN2 TENM3 COL14A1 LTBP2

1.38e-0518972558e0400fbab5a0755504275aef5cf7986149abab
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 TENM3 LRP1 COL14A1 C7

1.38e-05189725a153b83314cf52808f685296cff8c95af3f4983d
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 TENM3 LRP1 COL14A1 C7

1.38e-05189725e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 LRP1 COL14A1 LTBP2 C7

1.38e-05189725d531399749409d614adca13d181830c6e3287508
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 TENM3 C7 NUP153 ASAP1

1.42e-051907251121eb607a984c59fbffe7220837fc178745aa55
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 TENM3 LRP1 COL14A1 C7

1.42e-051907252306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 LRP1 COL14A1 LTBP2 C7

1.42e-05190725d13fd234caa3fc69d8a59bc0060cdacdf716ee55
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 TENM3 C7 NUP153 ASAP1

1.42e-05190725048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 TENM3 LRP1 COL14A1 C7

1.42e-051907251f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 TENM3 LRP1 COL14A1 C7

1.45e-05191725a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellControl-Myeloid-transitional_Macro|Control / Disease group,lineage and cell class (2021.01.30)

PLA2G2D PLXNC1 FOLR2 KCP CHIT1

1.45e-051917253ed0b1ff628a165e3c92c2e493206015f57dccfe
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 TENM3 LRP1 COL14A1 C7

1.45e-05191725b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 TENM3 FOXP2 COL14A1 THSD7B

1.45e-05191725b51e0f5d1b93f526160c904e9091313a5364f3a7
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FBN2 TENM3 NTRK2 COL14A1

1.45e-051917254b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCellASK440-Mesenchymal|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

FBN1 TENM1 COL14A1 LTBP2 C7

1.45e-05191725f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 TENM3 LRP1 COL14A1 C7

1.45e-0519172539092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FBN2 TENM3 NTRK2 COL14A1

1.45e-0519172575d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CRIM1 MEGF6 JAG1 COL14A1 FOXP1

1.45e-05191725b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCellASK440-Mesenchymal-Fibroblast|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

FBN1 TENM1 COL14A1 LTBP2 C7

1.45e-05191725387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FRAS1 FBN1 TENM3 LTBP2 C7

1.45e-051917256688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 TENM3 LRP1 COL14A1 C7

1.45e-05191725ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 TENM3 LRP1 COL14A1 C7

1.49e-051927259093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 TENM3 LRP1 COL14A1 C7

1.49e-051927256f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 NTRK2 LRP1 COL14A1 C7

1.49e-05192725853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FBN2 TENM3 COL14A1 LTBP2

1.49e-05192725ad48c941a3ddfd9a5146bafc2209da577bb50531
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 LRP1 COL14A1 LTBP2 C7

1.49e-05192725f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 TENM3 LRP1 COL14A1 C7

1.49e-051927259ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 TENM3 LRP1 COL14A1 C7

1.49e-05192725f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 TENM3 LRP1 COL14A1 C7

1.49e-05192725df1545670370fb1010c567cd059c2783eab315f7
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FRAS1 FBN1 TENM3 LTBP2 C7

1.49e-0519272599ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 TENM3 LRP1 COL14A1 C7

1.49e-05192725dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCellLPS_only-Stromal_mesenchymal|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 TENM3 LRP1 COL14A1 C7

1.49e-05192725162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 LRP1 COL14A1 LTBP2 C7

1.49e-0519272541a8326cd5bc19ad5041068501bab4c72399222e
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 NTRK2 LRP1 COL14A1 C7

1.49e-05192725d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 TENM3 LRP1 COL14A1 C7

1.49e-051927253d0cb19f037f604253d7d728689aeaa94251e92b
ComputationalPlacenta genes.

TNFRSF25 FBN2 CRIM1 FOLR2 CIAO1 JAG1 LRP1 GRN LTBP2

5.91e-05463429MODULE_38
DrugAcyclovir [59277-89-3]; Up 200; 17.8uM; MCF7; HT_HG-U133A

TENM3 NTRK2 ASAP3 TENM1 COL14A1 ADAM29 F9

2.99e-061977271543_UP
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2 FBN3

1.28e-083703DOID:65 (implicated_via_orthology)
Diseasedementia (is_implicated_in)

GRN NOTCH4 LRP8

2.77e-0612703DOID:1307 (is_implicated_in)
DiseaseWeill-Marchesani syndrome

FBN1 LTBP2

1.66e-053702C0265313
DiseaseWeill-Marchesani Syndrome, Autosomal Dominant

FBN1 LTBP2

1.66e-053702C1869115
DiseaseWeill-Marchesani Syndrome, Autosomal Recessive

FBN1 LTBP2

1.66e-053702C1869114
Diseasespecific developmental disorder (implicated_via_orthology)

FOXP2 FOXP1

3.32e-054702DOID:0060038 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

3.32e-054702DOID:0060249 (is_implicated_in)
DiseaseWeill-Marchesani syndrome

FBN1 LTBP2

3.32e-054702cv:C0265313
DiseaseWeill-Marchesani syndrome (is_implicated_in)

FBN1 LTBP2

3.32e-054702DOID:0050475 (is_implicated_in)
Diseaseschizophrenia (is_implicated_in)

FOXP2 FOXP1 NOTCH4 LRP8

3.63e-0578704DOID:5419 (is_implicated_in)
Diseasepulse pressure measurement

PAQR9 FBN1 FBN2 NEURL3 CRIM1 MEGF8 PLXNC1 JAG1 LRP1 FOXP1 LTBP2 OBI1

9.74e-0513927012EFO_0005763
Diseaseaortic aneurysm

FBN1 LRP1

2.47e-0410702EFO_0001666
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

FBN1 FBN2 JAG1

2.75e-0453703C4707243
DiseaseAlzheimer's disease (is_implicated_in)

NTRK2 LRP1 GRN LRP8

2.79e-04132704DOID:10652 (is_implicated_in)
Diseasecortical thickness

FBN1 FBN2 CRIM1 FOXP2 PLXNC1 UTP4 JAG1 LRP1 FOXP1 LRP8

2.84e-0411137010EFO_0004840
DiseaseMajor Depressive Disorder

FOXP2 NTRK2 LRP1 GRM5 LRP8

2.85e-04243705C1269683
Diseaseneuroticism measurement

TENM3 FOXP2 PLXNC1 LTBP2 GRM5 PRAG1 OBI1 F9 NOTCH4

2.90e-04909709EFO_0007660
DiseaseMarfan Syndrome

FBN1 LTBP2

3.01e-0411702C0024796
DiseaseUnipolar Depression

FOXP2 NTRK2 LRP1 GRM5 LRP8

3.81e-04259705C0041696
DiseaseLiver Cirrhosis, Experimental

PAQR9 ATRN FBN1 FOLR2 GRN C7 ITGB2 ST14

4.86e-04774708C0023893
DiseaseSjogren's syndrome (implicated_via_orthology)

MUC19 ST14

7.37e-0417702DOID:12894 (implicated_via_orthology)
Diseasemajor depressive disorder (is_implicated_in)

FOXP2 NTRK2

7.37e-0417702DOID:1470 (is_implicated_in)
Diseasebipolar disorder (is_marker_for)

NTRK2 GRN

9.24e-0419702DOID:3312 (is_marker_for)
DiseaseNerve Degeneration

ATRN GRN LRP8

1.03e-0383703C0027746
DiseaseSchizophrenia

FOXP2 NTRK2 JAG1 LRP1 GRN GRM5 NOTCH4 LRP8

1.14e-03883708C0036341
Diseasetooth agenesis

FOXP1 THSD7B

1.24e-0322702EFO_0005410
Diseaseage-related macular degeneration

C12orf50 GRM5 NOTCH4

1.25e-0389703EFO_0001365
Diseasecongenital heart disease (is_implicated_in)

JAG1 FOXP1

1.48e-0324702DOID:1682 (is_implicated_in)
Diseasechildhood trauma measurement

FOXP2 FOXP1

1.48e-0324702EFO_0007979
DiseaseCarcinoma, Pancreatic Ductal

JAG1 NOTCH4

1.48e-0324702C0887833
Diseasesystemic scleroderma (is_implicated_in)

FBN1 NOTCH4

1.48e-0324702DOID:418 (is_implicated_in)
Diseasecerebrospinal fluid biomarker measurement

WFIKKN2 C7 CHIT1

1.56e-0396703EFO_0006794
Diseasemigraine disorder

FBN2 LRP1 FOXP1 NOTCH4 ASAP1

1.60e-03357705MONDO_0005277
DiseaseAdenoid Cystic Carcinoma

FOXP2 JAG1 DTL

1.75e-03100703C0010606
Diseaseneuroticism measurement, cognitive function measurement

TENM3 FOXP2 FOXP1 THSD7B GRM5 LRP8

2.25e-03566706EFO_0007660, EFO_0008354
DiseaseRS-10-hydroxywarfarin to RS-warfarin ratio measurement

ATRN FRAS1 FBN3

2.30e-03110703EFO_0803335

Protein segments in the cluster

PeptideGeneStartEntry
ECDLPEWCNGTSHKC

ADAM29

461

Q9UKF5
ASCVVWKCCEDGTLE

EPB42

391

P16452
CCDCGAADPTWLSTN

ASAP3

441

Q8TDY4
CPFCRCEIKGWEAVS

CBLC

386

Q9ULV8
CPFWAEDGHCSIKDC

ERO1B

81

Q86YB8
WKQCPSCGAICTNTI

GVINP1

2286

Q7Z2Y8
DTCCQLTSGEWGCCP

GRN

376

P28799
VCWCPSDFTKIATCS

DTL

366

Q9NZJ0
CSIGAVWGVECEACP

FBN3

941

Q75N90
TKEKTLCCWFCTSGP

ARRDC3

176

Q96B67
SETGYWITCCPTCDV

RAG2

411

P55895
SSCCKWGCSKSEISS

RLN3

126

Q8WXF3
CITAWCSSKAECPLC

PEX10

296

O60683
PTGLVFSNSCKCCTW

CHIT1

451

Q13231
WKPDSCQSCRCHGDI

FRAS1

41

Q86XX4
SCAGCWGPTEKHCLA

FRAS1

516

Q86XX4
KECDWSCSACSGPLK

FRAS1

956

Q86XX4
GEVSCCWTCTPCKEN

GRM5

526

P41594
ECIPWKDNACCTLTT

IZUMO1R

46

A6ND01
KCNSGRCIPEHWTCD

LRP1

1021

Q07954
CECSENWKGEACDIP

ATRN

271

O75882
KECPACVETGCAWCK

PLXNC1

596

O60486
CQDAKWSCTEALCPG

MUC19

801

Q7Z5P9
WSCTEALCPGRCKVE

MUC19

806

Q7Z5P9
TSVGCNECTCIKGSW

MUC19

1251

Q7Z5P9
GSCKDDINSYECWCP

F9

106

P00740
GVCKWPGCESICEDF

FOXP2

346

O15409
GVCKWPGCEAVCEDF

FOXP1

306

Q9H334
SECFSSPKTGFWDCC

OBI1

456

Q5W0B1
DGEASTPRCKWCTNC

MEGF8

1946

Q7Z7M0
GEICTVDPCHKFTWC

NELFB

251

Q8WX92
SKCHQETVSLCCPGW

LMLN2

196

A0A1B0GTW7
ENSTEPWFCDACKCG

PHF14

366

O94880
AVACTVACCKSRTDW

PAQR9

221

Q6ZVX9
VCETSTCDIPVCWTK

OBSCN

3116

Q5VST9
SSCRECIESGPGCTW

ITGB2

31

P05107
AACWTCGFLCPISEV

OR6N2

146

Q8NGY6
SCCCSLGKAWGTPCE

FBN1

1561

P35555
VCSTSWANTDKCCEL

COL14A1

1421

Q05707
CPLWGKCDAESSKCV

C7

776

P10643
FVGRCCQTCTPKSWE

GPAT2

46

Q6NUI2
TEWPDGAKDCACSCH

GON4L

1841

Q3T8J9
SWKPDVCTSCICIDS

CRIM1

766

Q9NZV1
CSPWKKNACCTASTS

FOLR2

51

P14207
NDICCDCGSSEPTWL

ASAP1

451

Q9ULH1
CCCSRVGKAWGSECE

LTBP2

696

Q14767
CCAVGAAWGTECEEC

FBN2

1026

P35556
CVPASWRCDGEKDCE

LRP8

141

Q14114
KWTCCSKEVCGCDTT

OTOGL

1926

Q3ZCN5
FTCVCKEGWEGPICA

JAG1

766

P78504
EDCNTCTCTSGKWEC

OTOG

491

Q6ZRI0
GKWECSTAVCPAECS

OTOG

501

Q6ZRI0
WQACTCPVGVACDSV

MEGF6

696

O75095
ENIICSCISPCGSWI

UTP4

391

Q969X6
LCWEGSVSCEPKACA

KCP

751

Q6ZWJ8
AGVCSCDPKWTGSDC

TENM1

676

Q9UKZ4
CDPKWTGSDCSTELC

TENM1

681

Q9UKZ4
GAPCQECSRCSLWTD

RNF216

721

Q9NWF9
SCVCDVGWTGPECEA

NOTCH4

676

Q99466
PKDATDWCCQTHDCC

PLA2G2D

56

Q9UNK4
GVACSGSDPSWKCIC

CIAO1

231

O76071
CFWETQPLGCVKISC

C12orf50

11

Q8NA57
WRAAFACPTSCKCSA

NTRK2

26

Q16620
ACPTSCKCSASRIWC

NTRK2

31

Q16620
YNCSTCKGTEVSCWP

TMEM95

116

Q3KNT9
WIPDTNDEKVSACCC

SPEM3

111

A0A1B0GUW6
CKPLFWVCDSVNDCG

ST14

501

Q9Y5Y6
PQKWCCLECATTESV

USP49

21

Q70CQ1
EPGCSQCWCEDGKVT

VWCE

401

Q96DN2
ESLWVKSCSFTAACC

RNH1

316

P13489
WTGPDCSNEICSVDC

TENM3

671

Q9P273
SCGTDWDIVRKCICA

DHX38

1061

Q92620
KRPIGSWECSVCCVS

NUP153

791

P49790
GRDCSPTCWEQGKCS

PRAG1

281

Q86YV5
ADTRCGCKPGWFVEC

TNFRSF25

111

Q93038
CAWRVFSDTAKCPVC

NEURL3

226

Q96EH8
PCEECGCSFSWKSQL

ZNF446

396

Q9NWS9
LCNIPCSTDCIVSSW

THSD7B

476

Q9C0I4
PSCSWEAEGLHCSCS

SIGLEC10

451

Q96LC7
TSPTAYCDCWEKCKC

UBR5

1226

O95071
SECDIWDGQPVCKCK

WFIKKN2

121

Q8TEU8