Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A7 CYP2A13	3.75e-07	3	145	3	GO:0008389
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK1 RABEP2 ARFGEF2 ARFGEF1 GMIP VPS9D1 PLEKHG1 RIN1 LLGL2 TBC1D10A TBCK AKAP13 SESN2 RPGR RAPGEF2	4.41e-06	507	145	15	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK1 RABEP2 ARFGEF2 ARFGEF1 GMIP VPS9D1 PLEKHG1 RIN1 LLGL2 TBC1D10A TBCK AKAP13 SESN2 RPGR RAPGEF2	4.41e-06	507	145	15	GO:0030695
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DOCK1 ARFGEF2 ARFGEF1 VPS9D1 PLEKHG1 RIN1 TBC1D10A AKAP13 RPGR RAPGEF2	7.46e-06	231	145	10	GO:0005085
GeneOntologyMolecularFunction	calcium ion binding	SLC25A24 FAT4 NOX5 SPTA1 FSTL5 ANXA11 PCDHB14 CAPS PCDHB3 PCDHAC1 PCDHA3 DST NCAN USP32 PCDH11X RAPGEF2 CDH1 CDH12	8.49e-06	749	145	18	GO:0005509
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2A6 CYP2A7 CYP2A13 CYP2C8	2.53e-05	24	145	4	GO:0008392
GeneOntologyMolecularFunction	GTPase activator activity	DOCK1 RABEP2 ARFGEF1 GMIP VPS9D1 RIN1 LLGL2 TBC1D10A TBCK RAPGEF2	3.80e-05	279	145	10	GO:0005096
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2A6 CYP2A7 CYP2A13 CYP2C8	4.11e-05	27	145	4	GO:0008391
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP2A6 CYP2A7 CYP2A13 CYP2C8	1.04e-04	34	145	4	GO:0008395
GeneOntologyMolecularFunction	aromatase activity	CYP2A6 CYP2A7 CYP2A13 CYP2C8	1.17e-04	35	145	4	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2A6 CYP2A7 CYP2A13 CYP2C8	4.39e-04	49	145	4	GO:0016712
GeneOntologyMolecularFunction	protein kinase A binding	ARFGEF2 ARFGEF1 AKAP13 CRYBG3	8.35e-04	58	145	4	GO:0051018
GeneOntologyMolecularFunction	heme binding	CYP2A6 CYP2A7 CYP2A13 CYP2C8 NOX5 PXDNL	9.20e-04	154	145	6	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	CYP2A6 CYP2A7 CYP2A13 CYP2C8 NOX5 PXDNL	1.27e-03	164	145	6	GO:0046906
GeneOntologyMolecularFunction	enzyme regulator activity	DOCK1 RABEP2 COL6A3 ARFGEF2 ARFGEF1 CASP9 GMIP VPS9D1 PLEKHG1 RIN1 FRY LLGL2 FBXO5 TBC1D10A P2RX7 TBCK AKAP13 SESN2 RPGR RAPGEF2 PPP1R27	1.40e-03	1418	145	21	GO:0030234
GeneOntologyMolecularFunction	cell adhesion molecule binding	COL16A1 KRT18 ECM2 LAMB2 ITGA4 ITGAM DST TBC1D10A TNKS1BP1 CTNNA2 CDH1 CDH12	1.44e-03	599	145	12	GO:0050839
GeneOntologyMolecularFunction	integrin binding	COL16A1 ECM2 LAMB2 ITGA4 ITGAM DST	1.77e-03	175	145	6	GO:0005178
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	FAT4 CADM4 PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X CDH1 SDK1 CDH12	7.43e-07	187	143	10	GO:0007156
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	FAT4 CADM4 PCDHB14 PCDHB3 PCDHAC1 PCDHA3 ITGA4 ITGAM PCDH11X CDH1 SDK1 CDH12	1.95e-06	313	143	12	GO:0098742
GeneOntologyBiologicalProcess	epoxygenase P450 pathway	CYP2A6 CYP2A7 CYP2A13 CYP2C8	1.47e-05	22	143	4	GO:0019373
GeneOntologyBiologicalProcess	cell-cell adhesion	FAT4 KRT18 CADM4 PIEZO1 SPTA1 PKD1L1 PCDHB14 LAG3 PCDHB3 PCDHAC1 GPAM PCDHA3 ITGA4 ITGAM EFR3A DHPS PCDH11X CTNNA2 CDH1 SDK1 CDH12	1.71e-05	1077	143	21	GO:0098609
GeneOntologyBiologicalProcess	phenylpropanoid metabolic process	CYP2A6 CYP2A7 CYP2A13	3.78e-05	10	143	3	GO:0009698
GeneOntologyBiologicalProcess	coumarin metabolic process	CYP2A6 CYP2A7 CYP2A13	3.78e-05	10	143	3	GO:0009804
GeneOntologyBiologicalProcess	cell morphogenesis	EPHB2 NES SPTA1 LAMB2 LAMB3 CASP9 CUL7 ITGA4 DTNBP1 MAP3K1 FRY DST P2RX7 SMN1 SEMA6A CTNNA2 RAPGEF2 CFAP44 CDH1 CDH12 EPHB1	7.64e-05	1194	143	21	GO:0000902
GeneOntologyBiologicalProcess	synapse organization	EPHB2 DOCK1 RIMS3 PCDHB14 PCDHB3 LAMB2 LRRTM3 DTNBP1 ITGAM NCAN CTNNA2 RAPGEF2 CDH1 SDK1 EPHB1	8.47e-05	685	143	15	GO:0050808
GeneOntologyBiologicalProcess	cell junction organization	EPHB2 DOCK1 COL16A1 RIMS3 PCDHB14 PCDHB3 LAMB2 LRRTM3 DTNBP1 ITGAM DST NCAN CTNNA2 RAPGEF2 CDH1 SDK1 CDH12 EPHB1	1.42e-04	974	143	18	GO:0034330
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A7 CYP2A13	1.90e-06	4	147	3	IPR008067
Domain	Cadherin_CS	FAT4 PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X CDH1 CDH12	2.36e-06	109	147	8	IPR020894
Domain	CADHERIN_1	FAT4 PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X CDH1 CDH12	3.10e-06	113	147	8	PS00232
Domain	Cadherin	FAT4 PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X CDH1 CDH12	3.10e-06	113	147	8	PF00028
Domain	CADHERIN_2	FAT4 PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X CDH1 CDH12	3.31e-06	114	147	8	PS50268
Domain	-	FAT4 PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X CDH1 CDH12	3.31e-06	114	147	8	2.60.40.60
Domain	CA	FAT4 PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X CDH1 CDH12	3.54e-06	115	147	8	SM00112
Domain	Cadherin-like	FAT4 PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X CDH1 CDH12	3.77e-06	116	147	8	IPR015919
Domain	Cadherin	FAT4 PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X CDH1 CDH12	4.29e-06	118	147	8	IPR002126
Domain	Cadherin_2	PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X	1.59e-04	65	147	5	PF08266
Domain	Cadherin_N	PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X	1.59e-04	65	147	5	IPR013164
Domain	DCB_dom	ARFGEF2 ARFGEF1	3.65e-04	4	147	2	IPR032629
Domain	Sec7_C	ARFGEF2 ARFGEF1	3.65e-04	4	147	2	IPR015403
Domain	DUF1981	ARFGEF2 ARFGEF1	3.65e-04	4	147	2	PF09324
Domain	Sec7_N	ARFGEF2 ARFGEF1	3.65e-04	4	147	2	IPR032691
Domain	Sec7_N	ARFGEF2 ARFGEF1	3.65e-04	4	147	2	PF12783
Domain	DCB	ARFGEF2 ARFGEF1	3.65e-04	4	147	2	PF16213
Domain	Cyt_P450_E_grp-I	CYP2A6 CYP2A7 CYP2A13 CYP2C8	4.27e-04	45	147	4	IPR002401
Domain	EF_HAND_2	SLC25A24 NOX5 SPTA1 FSTL5 CAPS EFCAB13 DST USP32	4.95e-04	231	147	8	PS50222
Domain	FN3	EPHB2 COL6A3 INSRR IGSF22 TRIM36 SDK1 EPHB1	6.63e-04	185	147	7	SM00060
Domain	Cyt_P450_CS	CYP2A6 CYP2A7 CYP2A13 CYP2C8	8.00e-04	53	147	4	IPR017972
Domain	Galactose-bd-like	EPHB2 LAMB2 LAMB3 CUL7 EPHB1	8.83e-04	94	147	5	IPR008979
Domain	FN3	EPHB2 COL6A3 INSRR IGSF22 TRIM36 SDK1 EPHB1	1.02e-03	199	147	7	PS50853
Domain	CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13 CYP2C8	1.05e-03	57	147	4	PS00086
Domain	-	CYP2A6 CYP2A7 CYP2A13 CYP2C8	1.12e-03	58	147	4	1.10.630.10
Domain	p450	CYP2A6 CYP2A7 CYP2A13 CYP2C8	1.12e-03	58	147	4	PF00067
Domain	EF_HAND_1	SLC25A24 NOX5 FSTL5 CAPS EFCAB13 DST USP32	1.17e-03	204	147	7	PS00018
Domain	Cyt_P450	CYP2A6 CYP2A7 CYP2A13 CYP2C8	1.28e-03	60	147	4	IPR001128
Domain	FN3_dom	EPHB2 COL6A3 INSRR IGSF22 TRIM36 SDK1 EPHB1	1.35e-03	209	147	7	IPR003961
Domain	VWC	ECM2 PXDNL MUC5AC	1.35e-03	28	147	3	PF00093
Domain	ARM-type_fold	DOCK1 RTTN USP24 ARFGEF2 ARFGEF1 HUWE1 CUL7 MAP3K1 EFR3A	1.48e-03	339	147	9	IPR016024
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7 CYP2A13 CYP2C8	6.43e-07	11	96	4	M27130
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7 CYP2A13 CYP2C8	9.59e-07	12	96	4	MM14847
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2A13 CYP2C8	1.62e-05	23	96	4	M5372
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2A13 CYP2C8	2.29e-05	25	96	4	MM14846
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL6A3 COL16A1 LAMB2 LAMB3 ITGA4 ITGAM DST NCAN CDH1	2.04e-04	300	96	9	M610
Pathway	REACTOME_FATTY_ACIDS	CYP2A6 CYP2A7 CYP2A13	2.32e-04	18	96	3	MM14841
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	COL6A3 COL16A1 ITGA4 ITGAM CDH1	2.81e-04	85	96	5	M16441
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	RABEP2 USP24 CUL7 DST FBXO3 SUPT5H DHPS RBM6 SMN1 TNKS1BP1 TASOR	2.54e-09	212	151	11	33853758
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	31645370
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	8188299
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	8250953
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	2703500
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	22217847
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	22890016
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	3346244
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	2733794
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	8484736
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	1417950
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	32987105
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	2765478
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A7 CYP2A13	8.02e-08	3	151	3	2415518
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A7 CYP2A13	3.20e-07	4	151	3	10490589
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A7 CYP2A13	3.20e-07	4	151	3	1970547
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A7 CYP2A13	3.20e-07	4	151	3	9408084
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A7 CYP2A13	3.20e-07	4	151	3	7565685
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X CDH1	8.80e-07	74	151	6	10817752
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	COL16A1 CADM4 ARFGEF2 ARFGEF1 SLC1A4 VAMP3 EFR3A LLGL2 TBC1D10A USP32 PCDH11X SLC35F2 SEMA6A	1.35e-06	569	151	13	30639242
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP2A6 CYP2A7 CYP2A13 CYP2C8	1.57e-06	20	151	4	9890157
Pubmed	A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.	CYP2A6 CYP2A7 CYP2A13	1.59e-06	6	151	3	7668294
Pubmed	Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.	CYP2A6 CYP2A7 CYP2A13	1.59e-06	6	151	3	8587134
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	COL6A3 SPTA1 RTTN DST SCN5A CTNNA2 CFAP44 MUC5AC	1.73e-06	187	151	8	26460568
Pubmed	Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.	CYP2A6 CYP2A7 CYP2A13	2.77e-06	7	151	3	9630227
Pubmed	Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.	CYP2A6 CYP2A7 CYP2A13	2.77e-06	7	151	3	14630516
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	EPHB2 PCDH11X SEMA6A SDK1 CDH12 EPHB1	2.98e-06	91	151	6	28558017
Pubmed	Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse.	CYP2A6 CYP2A13 SPTA1	4.42e-06	8	151	3	2885848
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CCP110 NES KRT18 KIAA0232 ITPRID2 NARS2 NSD3 PLEKHG1 DST MAP4K1 AKAP13 SRPK3 TNKS1BP1 CRYBG3 RAPGEF2	5.67e-06	861	151	15	36931259
Pubmed	Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.	CYP2A6 CYP2A7 CYP2A13	6.61e-06	9	151	3	37838304
Pubmed	E-Cadherin regulates neural stem cell self-renewal.	NES CTNNA2 CDH1	9.41e-06	10	151	3	19321785
Pubmed	Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome.	EPHB2 TMEM163 EPHB1	9.41e-06	10	151	3	32092051
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	NES FAT4 DDX42 HUWE1 GMIP SMN1 TNKS1BP1 CTNNA2	1.30e-05	246	151	8	15345747
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RABEP2 KRT18 BAG5 PSMC1 ITPRID2 HUWE1 CUL7 DTNBP1 NSD3 VAMP3 EFR3A FBXO3 SUPT5H DHPS CRYBG3 TRIM36	1.43e-05	1049	151	16	27880917
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	DOCK1 USP24 ARFGEF1 LAMB2 GSS LLGL2 HSPA14	1.62e-05	183	151	7	31932471
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	1.87e-05	2	151	2	12325023
Pubmed	Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.	CYP2A6 CYP2A13	1.87e-05	2	151	2	30876690
Pubmed	CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.	CYP2A6 CYP2A13	1.87e-05	2	151	2	21395539
Pubmed	Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.	CYP2A6 CYP2A13	1.87e-05	2	151	2	12162851
Pubmed	Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.	CYP2A6 CYP2A13	1.87e-05	2	151	2	1302041
Pubmed	Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.	CYP2A6 CYP2A13	1.87e-05	2	151	2	8395817
Pubmed	Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.	CYP2A6 CYP2A13	1.87e-05	2	151	2	25804444
Pubmed	Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.	CYP2A6 CYP2A13	1.87e-05	2	151	2	1520280
Pubmed	EphB2 receptor cell-autonomous forward signaling mediates auditory memory recall and learning-driven spinogenesis.	EPHB2 EPHB1	1.87e-05	2	151	2	31633063
Pubmed	Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.	CYP2A6 CYP2A13	1.87e-05	2	151	2	23917075
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	1.87e-05	2	151	2	16636685
Pubmed	Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to Mechanical Cues.	PIEZO1 ITGAM	1.87e-05	2	151	2	34630381
Pubmed	Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.	CYP2A6 CYP2A13	1.87e-05	2	151	2	27902773
Pubmed	Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.	ARFGEF2 ARFGEF1	1.87e-05	2	151	2	23918382
Pubmed	Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.	CYP2A6 CYP2A13	1.87e-05	2	151	2	30154104
Pubmed	Expression of CYP2A genes in human liver and extrahepatic tissues.	CYP2A7 CYP2A13	1.87e-05	2	151	2	10353262
Pubmed	Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.	CYP2A6 CYP2A13	1.87e-05	2	151	2	21418183
Pubmed	Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.	ARFGEF2 ARFGEF1	1.87e-05	2	151	2	17360629
Pubmed	Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.	ARFGEF2 ARFGEF1	1.87e-05	2	151	2	10716990
Pubmed	Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.	ARFGEF2 ARFGEF1	1.87e-05	2	151	2	18203920
Pubmed	Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.	CYP2A6 CYP2A13	1.87e-05	2	151	2	19923441
Pubmed	Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.	CYP2A6 CYP2A13	1.87e-05	2	151	2	12499123
Pubmed	Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.	CYP2A6 CYP2A13	1.87e-05	2	151	2	22497566
Pubmed	USP32 confers cancer cell resistance to YM155 via promoting ER-associated degradation of solute carrier protein SLC35F2.	USP32 SLC35F2	1.87e-05	2	151	2	34815782
Pubmed	Complex Modes of Inheritance in Hereditary Red Blood Cell Disorders: A Case Series Study of 155 Patients.	PIEZO1 SPTA1	1.87e-05	2	151	2	34201899
Pubmed	The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.	CYP2A6 CYP2A13	1.87e-05	2	151	2	26363552
Pubmed	Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.	ARFGEF2 ARFGEF1	1.87e-05	2	151	2	18417613
Pubmed	Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.	CYP2A6 CYP2A13	1.87e-05	2	151	2	2712571
Pubmed	CpG island hypermethylation of E-cadherin (CDH1) and integrin alpha4 is associated with recurrence of early stage esophageal squamous cell carcinoma.	ITGA4 CDH1	1.87e-05	2	151	2	18697202
Pubmed	Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.	CYP2A6 CYP2A13	1.87e-05	2	151	2	22696418
Pubmed	Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.	CYP2A6 CYP2A13	1.87e-05	2	151	2	30222954
Pubmed	Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.	CYP2A6 CYP2A13	1.87e-05	2	151	2	7543189
Pubmed	Characterization and regulation of sex-specific mouse steroid hydroxylase genes.	CYP2A6 CYP2A13	1.87e-05	2	151	2	2372744
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	1.87e-05	2	151	2	2322567
Pubmed	Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.	CYP2A6 CYP2A13	1.87e-05	2	151	2	21473878
Pubmed	The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.	CYP2A6 CYP2A13	1.87e-05	2	151	2	7581481
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	1.87e-05	2	151	2	7864805
Pubmed	Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.	CYP2A6 CYP2A13	1.87e-05	2	151	2	28298240
Pubmed	Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.	CYP2A6 CYP2A13	1.87e-05	2	151	2	6309775
Pubmed	NEW GENETIC MARKERS ASSOCIATED WITH SUSCEPTIBILITY TO EXFOLIATION SYNDROME AMONG GEORGIAN POPULATION.	POMP SEMA6A	1.87e-05	2	151	2	31687947
Pubmed	Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.	CYP2A6 CYP2A13	1.87e-05	2	151	2	22262919
Pubmed	Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.	CYP2A6 CYP2A13	1.87e-05	2	151	2	25635819
Pubmed	Genetic variation between mice in their metabolism of coumarin and its derivatives.	CYP2A6 CYP2A13	1.87e-05	2	151	2	566237
Pubmed	Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.	CYP2A6 CYP2A13	1.87e-05	2	151	2	8611142
Pubmed	Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	1.87e-05	2	151	2	10212200
Pubmed	Coumarin toxicity in different strains of mice.	CYP2A6 CYP2A13	1.87e-05	2	151	2	665441
Pubmed	Misexpression of the constitutive Rpgr(ex1-19) variant leads to severe photoreceptor degeneration.	SEMA6A RPGR	1.87e-05	2	151	2	21546531
Pubmed	Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.	CYP2A6 CYP2A13	1.87e-05	2	151	2	24104196
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FAM47A FAT4 PCDHB14 PSMC1 LAMB3 GPAM HUWE1 REV3L FRY MYO15B DST AKAP13 CFAP44	2.12e-05	736	151	13	29676528
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X	2.22e-05	77	151	5	10835267
Pubmed	Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.	NES RAPGEF2 CDH1	2.22e-05	13	151	3	27390776
Pubmed	Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain.	EPHB2 NES EPHB1	2.22e-05	13	151	3	16421308
Pubmed	A protein interaction landscape of breast cancer.	ANXA11 BAG5 CARS1 LAMB3 ITPRID2 CUL7 RIN1 DST SUPT5H DHPS CTNNA2 CDH1	2.28e-05	634	151	12	34591612
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHB14 PCDHB3 PCDHAC1 PCDHA3 PCDH11X	2.67e-05	80	151	5	10716726
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIEZO1 ANXA11 RTTN ARFGEF2 LAMB2 LAMB3 HUWE1 REV3L NSD3 PLEKHG1 LLGL2 DST SCN5A AKAP13 TNKS1BP1 SMG6	2.69e-05	1105	151	16	35748872
Pubmed	Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.	CYP2A6 CYP2A13 CYP2C8	2.82e-05	14	151	3	19290787
Pubmed	Ephrin B1 maintains apical adhesion of neural progenitors.	EPHB2 NES EPHB1	2.82e-05	14	151	3	23578932
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP2A6 CYP2A7 CYP2A13	3.51e-05	15	151	3	29968852
Pubmed	PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS.	EPHB2 NES EPHB1	4.31e-05	16	151	3	38429579
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK1 ANXA11 DDX42 USP24 PSMC1 ARFGEF2 HUWE1 MYO15B MAGED2 SMN1 TNKS1BP1	5.11e-05	582	151	11	20467437
Pubmed	Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm.	EPHB2 NES EPHB1	5.22e-05	17	151	3	12971893
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP2A6 CYP2A7 CYP2A13	5.22e-05	17	151	3	27197076
Pubmed	Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.	FAT4 USP25 TNKS1BP1	5.22e-05	17	151	3	22153077
Interaction	CYP2A7 interactions	CYP2A6 CYP2A7 CYP2A13	3.88e-07	3	148	3	int:CYP2A7
GeneFamily	EF-hand domain containing	SLC25A24 NOX5 SPTA1 FSTL5 CAPS EFCAB13 DST USP32	2.34e-05	219	97	8	863
GeneFamily	Cytochrome P450 family 2	CYP2A6 CYP2A7 CYP2A13 CYP2C8	3.59e-05	35	97	4	1001
GeneFamily	Fibronectin type III domain containing	EPHB2 INSRR IGSF22 TRIM36 SDK1 EPHB1	2.22e-04	160	97	6	555
GeneFamily	Clustered protocadherins	PCDHB14 PCDHB3 PCDHAC1 PCDHA3	3.87e-04	64	97	4	20
GeneFamily	VPS9 domain containing	VPS9D1 RIN1	1.25e-03	10	97	2	928
GeneFamily	Laminin subunits	LAMB2 LAMB3	1.82e-03	12	97	2	626
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB2 EPHB1	2.49e-03	14	97	2	1095
GeneFamily	Ubiquitin specific peptidases	USP24 USP25 USP32	3.38e-03	56	97	3	366
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA4 ITGAM	4.12e-03	18	97	2	1160
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	KRT18 PIEZO1 LAMB2 LAMB3 ITPRID2 BCLAF3 IFIH1 LLGL2 DST SUPT5H RBM6	6.84e-11	194	151	11	88db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	KRT18 PIEZO1 LAMB2 LAMB3 ITPRID2 BCLAF3 IFIH1 LLGL2 DST SUPT5H RBM6	6.84e-11	194	151	11	a71728202493d4858342ea2756ea281cd0d99a3a
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CAPS THUMPD3 IFIH1 FRY DST FBXO5 USP32 SMN1	1.54e-07	175	151	8	da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB2 ANXA11 USP24 NAALADL2 DST ABCA6 STK39 CDH1	2.78e-07	189	151	8	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FSTL5 LAMB3 AGBL4 PLEKHG1 FRY LLGL2 CDH1 MUC5AC	3.13e-07	192	151	8	b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB2 KRT18 ANXA11 NAALADL2 AGBL4 AKAP13 STK39 CDH1	3.39e-07	194	151	8	46070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB2 KRT18 ANXA11 NAALADL2 AGBL4 AKAP13 STK39 CDH1	3.39e-07	194	151	8	abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 COL16A1 LRRTM3 NAALADL2 ABCA6 PXDNL SETBP1 SDK1	3.39e-07	194	151	8	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 USP25 VTI1A NAALADL2 RBM6 STK39 RAPGEF2 UMAD1	4.11e-07	199	151	8	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CAPS THUMPD3 IFIH1 FRY DST FBXO5 USP32	2.30e-06	175	151	7	334fad1a147de6c007cec5089c02c35cf3220f1b
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FSTL5 LAMB3 PLEKHG1 FRY LLGL2 TMEM163 CDH1	3.09e-06	183	151	7	c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	FAT4 ECM2 LRRTM3 REV3L ITGA4 ABCA6 CRYBG3	3.21e-06	184	151	7	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ANXA11 USP24 NAALADL2 DST ABCA6 STK39 CDH1	3.57e-06	187	151	7	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	15-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	KRT18 AARD FSTL5 CAPS TRIM36 CDH1 MUC5AC	3.69e-06	188	151	7	9a64fb07de611de38d6f24673feb3b81a5e85384
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL6A3 FAT4 COPZ2 COL16A1 OLFML2B MAGED2 CTNNA2	4.10e-06	191	151	7	053b3664f509baa107feaf90730f80ebf9ac8f14
ToppCell	18-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	CYP2A6 CYP2A7 CYP2A13 KRT18 AARD CAPS LAMB3	4.24e-06	192	151	7	9fae988ecd2ef1231bfd42a678a4903517694cbe
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	VTI1A AGBL4 SETBP1 RBM6 AKAP13 RAPGEF2 SDK1	4.24e-06	192	151	7	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 COPZ2 COL16A1 OLFML2B ECM2 LAMB2 MAGED2	4.39e-06	193	151	7	428b1a3ad87dff7f65de5161d40f102572a9341b
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EPHB2 FAT4 COL16A1 OLFML2B ECM2 ABCA6 SETBP1	4.54e-06	194	151	7	439d3f17c1f4736122b330e98add9292c7036a8e
ToppCell	PCW_05-06-Epithelial\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FSTL5 LAMB3 PLEKHG1 FRY LLGL2 TMEM163 CDH1	4.54e-06	194	151	7	47a1369c22fcbfe00b08376eb610a61c355548db
ToppCell	PCW_07-8.5-Epithelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FSTL5 LAMB3 PLEKHG1 FRY LLGL2 TMEM163 CDH1	4.54e-06	194	151	7	f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSRR ARFGEF1 HUWE1 REV3L ZC3H3 DST TMEM163	4.70e-06	195	151	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSRR ARFGEF1 HUWE1 REV3L ZC3H3 DST TMEM163	4.70e-06	195	151	7	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D122\|Adult / Lineage, Cell type, age group and donor	COL6A3 COL16A1 ECM2 DST ABCA6 SETBP1 SDK1	4.70e-06	195	151	7	aa0add081881d349099d12efca5cdee098038d4e
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 VTI1A NAALADL2 TMEM163 STK39 RAPGEF2 SDK1	4.86e-06	196	151	7	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB2 KRT18 EFCAB13 NAALADL2 AGBL4 LLGL2 SDK1	5.02e-06	197	151	7	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A13 KRT18 STK39 CFAP44 CDH1 MUC5AC	5.02e-06	197	151	7	5c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A3 FAT4 COL16A1 ECM2 INSRR ABCA6 SETBP1	5.02e-06	197	151	7	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	COL6A3 FAT4 COL16A1 DST ABCA6 SETBP1 SDK1	5.37e-06	199	151	7	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COL6A3 COL16A1 REV3L DST ABCA6 PXDNL SDK1	5.55e-06	200	151	7	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A2\|343B / Donor, Lineage, Cell class and subclass (all cells)	EPHB2 ARFGEF2 ARFGEF1 LRCH1 FAM30A VPS9D1	6.24e-06	133	151	6	8ff1cf0ea1fc33fe8384c0e65c1ee1853b25a2ae
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Brinp3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL16A1 OLFML2B RIN1 LLGL2 FAM43A EPHB1	1.99e-05	163	151	6	b0aa4a620bd58011225b42ea6dda04e3101ba342
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GTF2A1L SPNS3 ITGA4 MAP4K1 TMEM163 SRPK3	2.21e-05	166	151	6	4b31d2755108b2815316411a38bfb11fd30ef98a
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A3 COL16A1 ECM2 TBC1D10A MAGED2 SDK1	2.21e-05	166	151	6	37794a84601a2a949d579663d4a4bb8bc8fb5923
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A3 COL16A1 ECM2 TBC1D10A MAGED2 SDK1	2.21e-05	166	151	6	81c546c6d847e49e662b81e71992ca0f7a99e890
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PIEZO1 BCLAF3 IFIH1 DST SUPT5H RBM6	2.44e-05	169	151	6	665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NES FAT4 GTF2A1L OLFML2B PCDHB14 LRRTM3	2.44e-05	169	151	6	87116c33c5ca8cb1862e103e5607b1df4d264569
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PIEZO1 BCLAF3 IFIH1 DST SUPT5H RBM6	2.44e-05	169	151	6	6614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell	NS-critical-d_0-4-Epithelial-FOXN4+\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CYP2A13 CADM4 RTTN LAMB2 NAALADL2 SMN1	2.69e-05	172	151	6	a00bb44d33658cb3a98accd6b60f3ce964c425b4
ToppCell	Immune_cells-B_cell\|Immune_cells / Lineage and Cell class	LAMB3 MAP4K1 TMEM163 SRPK3 CDH1 FAM43A	2.69e-05	172	151	6	b646894b691a99bf2742bd9da8e578dff0e87f1f
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KRT18 LAMB3 TNNI3K MYO15B LLGL2 CDH1	2.78e-05	173	151	6	45808cf69122c16b9d2b5ffa06d15392c55954b7
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KRT18 LAMB3 TNNI3K MYO15B LLGL2 CDH1	2.78e-05	173	151	6	7fa9dbcb258c3ab974490063951620e2def03db1
ToppCell	Control-B_cells-B_cells\|Control / group, cell type (main and fine annotations)	RABEP2 ITGA4 FAM30A MAP3K1 PLEKHG1 SETBP1	3.06e-05	176	151	6	d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell	IIH-CD8-antiviral_CD4\|IIH / Condition, Cell_class and T cell subcluster	RABEP2 RTTN BCLAF3 FBXO3 SESN2 STK39	3.16e-05	177	151	6	fe73608c40701eca88b260aeb5c0640d7bee72ba
ToppCell	facs-Kidney-nan-18m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RABEP2 DDX42 ITGA4 MAP3K1 MAP4K1 SRPK3	3.37e-05	179	151	6	f4fd214a9865c635d8a744ce5e0eff45174d3de4
ToppCell	facs-Kidney-nan-18m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RABEP2 DDX42 ITGA4 MAP3K1 MAP4K1 SRPK3	3.37e-05	179	151	6	57d8d44a793314eec8f77030f4177bfe21d41652
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EPHB2 ARFGEF2 ARFGEF1 LRCH1 FAM30A VPS9D1	3.48e-05	180	151	6	62511d76d24b836839c3dcc2bf30485ffe9401e2
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSRR USP24 PCDHB3 TNNI3K TMEM163	3.51e-05	109	151	5	0d4128af237afcc0adb4dfdd206fa3ddbe5b0e86
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FSTL5 RIMS3 PCDHA3 AGBL4 SCN5A CTNNA2	3.58e-05	181	151	6	7f99002a6411117cc2361334c7c9228e20c574b4
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FAT4 DST PXDNL SETBP1 SEMA6A EPHB1	4.17e-05	186	151	6	7def03dd856b765bd3f493288641981c4f7fd26e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB2 ANXA11 LAMB3 NAALADL2 DST STK39	4.30e-05	187	151	6	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB2 ANXA11 LAMB3 NAALADL2 DST STK39	4.30e-05	187	151	6	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB2 ANXA11 LAMB3 NAALADL2 DST STK39	4.30e-05	187	151	6	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	COL6A3 FAT4 ECM2 DST ABCA6 SETBP1	4.30e-05	187	151	6	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	OLFML2B EFCAB13 FRY TMEM163 CDH1 SLC4A11	4.43e-05	188	151	6	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	KRT18 LAMB3 ZC3H3 LLGL2 ZSCAN30 MSANTD4	4.43e-05	188	151	6	c74771584b3ba9561a99a54bf55a9203ddf8eff8
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)\|368C / Donor, Lineage, Cell class and subclass (all cells)	KRT18 LAMB3 ZC3H3 LLGL2 ZSCAN30 MSANTD4	4.43e-05	188	151	6	9155b9a92496e75646778c025b02947e9e9ec73a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KRT18 LAMB3 LLGL2 TMEM163 STK39 CDH1	4.43e-05	188	151	6	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	OLFML2B EFCAB13 FRY TMEM163 CDH1 SLC4A11	4.43e-05	188	151	6	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	Entopeduncular-Endothelial\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SLC25A24 NES COPZ2 ECM2 LAMB2 ITGA4	4.43e-05	188	151	6	94774652fd42bad5012356672ffac8b6d2c22d37
ToppCell	Substantia_nigra-Endothelial\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC25A24 NES COPZ2 ECM2 LAMB2 IFIH1	4.56e-05	189	151	6	bef8234bd9c4d6e3cdef0791d8066b39ba56ebba
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 COL16A1 LRRTM3 ABCA6 PXDNL SDK1	4.56e-05	189	151	6	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NAALADL2 AGBL4 FRY SETBP1 CDH1 SDK1	4.56e-05	189	151	6	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FSTL5 LAMB3 PLEKHG1 FRY LLGL2 CDH1	4.56e-05	189	151	6	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	Globus_pallidus-Endothelial\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	NES COPZ2 ECM2 LAMB2 IFIH1 LLGL2	4.56e-05	189	151	6	ad7dc9d25edd68fb624380a082c389fe7d640e7d
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NES COL6A3 KRT18 OLFML2B ITGA4 PXDNL	4.56e-05	189	151	6	9c2492c38f27e4c699b40680652e4c64911cce52
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 COL16A1 ABCA6 PXDNL SETBP1 SDK1	4.56e-05	189	151	6	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMB3 PLEKHG1 FRY LLGL2 TMEM163 CDH1	4.70e-05	190	151	6	c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NAALADL2 AGBL4 FRY SETBP1 CDH1 SDK1	4.70e-05	190	151	6	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	COL6A3 COL16A1 DST ABCA6 SETBP1 SDK1	4.70e-05	190	151	6	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	Club\|World / shred by cell class for parenchyma	CYP2A13 CAPS LAG3 MUC5AC CDH12 SLC4A11	4.70e-05	190	151	6	1974d559d7fee6cb68065b18af8bd38b64910622
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 COL16A1 ABCA6 PXDNL SETBP1 SDK1	4.84e-05	191	151	6	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FSTL5 LAMB3 PLEKHG1 LLGL2 CDH1 MUC5AC	4.84e-05	191	151	6	05731ece7867659c662f952812805f947032fe10
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A3 FAT4 DST ABCA6 SETBP1 SDK1	4.84e-05	191	151	6	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EPHB2 COL16A1 OLFML2B ECM2 ABCA6 SETBP1	4.98e-05	192	151	6	8d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMB3 AGBL4 PLEKHG1 LLGL2 TMEM163 CDH1	4.98e-05	192	151	6	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 COL16A1 LRRTM3 ABCA6 PXDNL SDK1	4.98e-05	192	151	6	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 COL16A1 ABCA6 PXDNL SETBP1 SDK1	4.98e-05	192	151	6	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 COL16A1 LRRTM3 ABCA6 PXDNL SDK1	4.98e-05	192	151	6	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A7 CYP2A13 KRT18 MAGED2 MUC5AC	5.12e-05	193	151	6	605fc2a25ed6846fb283b2918cfed98df6039d6b
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A3 COL16A1 ECM2 GPAM LRRTM3 NLRP5	5.12e-05	193	151	6	64edc1d6fb0fe117767d494cf4a5723bf8be2804
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 COL16A1 ABCA6 PXDNL SETBP1 SDK1	5.12e-05	193	151	6	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	PCW_05-06-Epithelial-Epithelial_airway\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FSTL5 LAMB3 PLEKHG1 FRY LLGL2 CDH1	5.12e-05	193	151	6	af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	COL6A3 FAT4 DST ABCA6 SETBP1 SDK1	5.12e-05	193	151	6	acad568621ed677031797b8c2e34dafea798d681
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KRT18 FSTL5 LAMB3 PLEKHG1 CDH1 MUC5AC	5.12e-05	193	151	6	de569c6e507856fd3ac2311f246cb597074ed30c
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A3 COL16A1 DST ABCA6 SETBP1 SDK1	5.27e-05	194	151	6	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NES AARD OLFML2B ECM2 LAG3 LAMB2	5.27e-05	194	151	6	c992e3357f4bf3069f8d697803e5785e49a2ef0a
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 COL16A1 LRRTM3 ABCA6 PXDNL SDK1	5.27e-05	194	151	6	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FSTL5 LAMB3 PLEKHG1 FRY LLGL2 CDH1	5.27e-05	194	151	6	b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FSTL5 LAMB3 AGBL4 LLGL2 TMEM163 CDH1	5.27e-05	194	151	6	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FSTL5 LAMB3 PLEKHG1 FRY LLGL2 CDH1	5.27e-05	194	151	6	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 MAP3K1 PLEKHG1 LLGL2 DST SDK1	5.43e-05	195	151	6	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 COL16A1 OLFML2B ECM2 LAMB2 MAGED2	5.43e-05	195	151	6	69a29d03e664b72f32d41876510c62345c3aed31
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A3 FAT4 COL16A1 ECM2 DST ABCA6	5.43e-05	195	151	6	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	LRRTM3 FRY DST PXDNL SCN5A AKAP13	5.43e-05	195	151	6	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	COL6A3 COL16A1 DST ABCA6 SETBP1 SDK1	5.43e-05	195	151	6	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK1 MAP3K1 PLEKHG1 LLGL2 DST SDK1	5.43e-05	195	151	6	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	facs-GAT-Fat-3m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 COL16A1 OLFML2B ECM2 LAMB2 MAGED2	5.43e-05	195	151	6	1cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCell	facs-Trachea-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A3 COPZ2 OLFML2B ECM2 LAMB2 MAGED2	5.43e-05	195	151	6	0d1876f6fdc1eafeb60d6fd7da5bce737d2b4a5a
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 COL16A1 OLFML2B ECM2 LAMB2 MAGED2	5.43e-05	195	151	6	9cef6f18664518060af7c192310dddce6d70345a
Computational	Adhesion molecules.	COL6A3 COL16A1 ECM2 LAMB2 LAMB3 ITGAM NCAN CDH1	2.86e-05	141	93	8	MODULE_122
Drug	2'-methoxyacetophenone	CYP2A6 CYP2A7 CYP2A13	2.80e-07	3	150	3	CID000068481
Drug	NSC35549	CYP2A6 CYP2A7 CYP2A13 MAGED2	1.21e-05	22	150	4	CID000411697
Drug	HCFC-123	CYP2A6 CYP2C8 CAPS CTNNA2	1.45e-05	23	150	4	CID000009385
Drug	nitro-L	CYP2A6 CYP2A7 CYP2A13 CYP2C8 KRT18	1.58e-05	48	150	5	CID000006849
Drug	BP-9,10-oxide	CYP2A6 CYP2A7 CYP2A13 CYP2C8	2.82e-05	27	150	4	CID000037456
Drug	Brn 4136738	CYP2A6 CYP2A7 CYP2A13 CYP2C8	2.82e-05	27	150	4	CID000050331
Drug	C14845	CYP2A6 CYP2A7 CYP2A13 CYP2C8	2.82e-05	27	150	4	CID011954064
Drug	p-Chloromercuribenzoic Acid	EPHB2 KRT18 BAG5 THUMPD3 CARS1 VTI1A ITPRID2 REV3L ITGA4 FBXO3 TBC1D10A NCAN TMEM163 MPHOSPH8 SESN2 SEMA6A CDH1 EPHB1	3.11e-05	908	150	18	ctd:D020245
Drug	norverapamil	CYP2A6 CYP2A13 CYP2C8 KCNJ2	3.28e-05	28	150	4	CID000104972
Drug	9-OH-BaP-4,5-oxide	CYP2A6 CYP2A7 CYP2A13 CYP2C8	3.28e-05	28	150	4	CID000115064
Drug	propargyl ether	CYP2A6 CYP2A13	4.31e-05	2	150	2	ctd:C531209
Drug	Hempa	CYP2A6 CYP2A13	4.31e-05	2	150	2	ctd:D006492
Drug	DPCO	DHPS AKAP13	4.31e-05	2	150	2	CID000126454
Drug	nicotine imine	CYP2A6 CYP2A13	4.31e-05	2	150	2	ctd:C034629
Drug	alpha-nicotyrine	CYP2A6 CYP2A13	4.31e-05	2	150	2	ctd:C008615
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	4.31e-05	2	150	2	ctd:C036676
Drug	19-hydroxytestosterone	CYP2A6 CYP2A7 CYP2A13 CYP2C8	4.34e-05	30	150	4	CID000150968
Drug	11-H-14,15-EETA	CYP2A6 CYP2A7 CYP2A13 CYP2C8	4.34e-05	30	150	4	CID011954058
Drug	bromobenzene	CYP2A6 CYP2A7 CYP2A13 CYP2C8 KRT18 GSS	4.46e-05	97	150	6	CID000007961
Drug	H-89, Dihydrochloride; Down 200; 0.5uM; MCF7; HT_HG-U133A	RABEP2 SLC1A4 NSD3 RIN1 SEMA6A RPGR CFAP44 SMG6	5.21e-05	198	150	8	6878_DN
Drug	BP-7,8-oxide	CYP2A6 CYP2A7 CYP2A13 CYP2C8	5.64e-05	32	150	4	CID000037455
Drug	chlorzoxazone	CYP2A6 CYP2A7 CYP2A13 CYP2C8 ZNF77	6.00e-05	63	150	5	CID000002733
Drug	12(13)-EpOME	CYP2A6 CYP2A7 CYP2A13 CYP2C8	7.20e-05	34	150	4	CID000001416
Drug	TCEO	CYP2A6 CYP2A7 CYP2A13 CYP2C8	7.20e-05	34	150	4	CID000028167
Drug	AC1O5XSP	CYP2A6 CYP2A7 CYP2A13 CYP2C8	7.20e-05	34	150	4	CID006442739
Drug	d 6-20	CYP2A6 CYP2A13 CYP2C8	7.64e-05	13	150	3	CID000161569
Drug	AC1L1CJI	CYP2A6 CYP2A7 CYP2A13 CYP2C8	8.08e-05	35	150	4	CID000001929
Disease	QRS amplitude, QRS complex	OLFML2B USP25 VTI1A LRCH1 GSS	4.74e-06	50	145	5	EFO_0005054, EFO_0007742
Disease	Colorectal Carcinoma	CYP2A6 FSTL5 ARFGEF1 LAMB3 VTI1A SPNS3 TNNI3K P2RX7 ABCA6 PUS10 SETBP1 PCDH11X SESN2 CDH1	1.01e-05	702	145	14	C0009402
Disease	fish oil supplement exposure measurement, total cholesterol measurement	USP24 ABCA6	2.40e-05	2	145	2	EFO_0004574, EFO_0600007
Disease	smoking behavior	CYP2A6 CYP2A7 COL16A1 REV3L TNNI3K SETBP1 CTNNA2 SDK1 SMG6	5.06e-05	341	145	9	EFO_0004318
Disease	APOE carrier status, cerebral amyloid angiopathy	FSTL5 EFR3A SETBP1 CDH1	5.42e-05	42	145	4	EFO_0006790, EFO_0007659
Disease	lymphocyte activation gene 3 protein measurement	LAG3 ABCA6	7.17e-05	3	145	2	EFO_0020540
Disease	Heterotopia, Periventricular, Autosomal Recessive	FAT4 ARFGEF2	7.17e-05	3	145	2	C1842563
Disease	unipolar depression, bipolar disorder	FAT4 FSTL5 BAG5 PXDNL NCAN SETBP1	1.26e-04	156	145	6	EFO_0003761, MONDO_0004985
Disease	fish oil supplement exposure measurement, low density lipoprotein cholesterol measurement	USP24 ABCA6	1.43e-04	4	145	2	EFO_0004611, EFO_0600007
Disease	alcohol dependence, heroin dependence, methamphetamine dependence	AGBL4 CTNNA2	1.43e-04	4	145	2	EFO_0004240, EFO_0004701, MONDO_0007079
Disease	urate measurement, bone density	CYP2C8 DDX12P FSTL5 DTNBP1 NAALADL2 RBM6 CTNNA2 CDH12 SLC4A11 UMAD1 EPHB1	2.54e-04	619	145	11	EFO_0003923, EFO_0004531
Disease	bilirubin measurement	FAT4 PIEZO1 SPTA1 DDX42 CARS1 GPAM REV3L SMG6 EPHB1	3.53e-04	442	145	9	EFO_0004570
Disease	thoracic aortic aneurysm	COL16A1 AARD TRIM36	4.28e-04	30	145	3	EFO_0004282
Disease	alcohol dependence, risky sexual behaviour measurement	FSTL5 IGSF22	6.59e-04	8	145	2	EFO_0007877, MONDO_0007079
Disease	reticulocyte measurement	PIEZO1 SPTA1 ARFGEF2 ITGA4 LRCH1 NARS2 MAP3K1 SETBP1 USP32 RBM6 AKAP13 CDH1 SLC4A11 SMG6	7.12e-04	1053	145	14	EFO_0010700
Disease	visceral adipose tissue measurement, body mass index	GPATCH2 PCDHAC1 PCDHA3 EPHB1	9.08e-04	87	145	4	EFO_0004340, EFO_0004765
Disease	electrocardiography	OLFML2B VTI1A LRCH1 GSS KCNJ2 SEC11A SETBP1 SCN5A RBM6	1.28e-03	530	145	9	EFO_0004327
Disease	Tachycardia, Ventricular	KCNJ2 SCN5A	1.28e-03	11	145	2	C0042514
Disease	QRS complex, QRS duration	VTI1A SETBP1 SCN5A	1.42e-03	45	145	3	EFO_0005054, EFO_0005055
Disease	JT interval	OLFML2B KIAA0232 VTI1A LRCH1 SCN5A TASOR	1.46e-03	248	145	6	EFO_0007885
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7	1.53e-03	12	145	2	EFO_0007794
Disease	paraxanthine measurement	CYP2A6 NOX5	1.53e-03	12	145	2	EFO_0021178
Disease	Mouth Diseases	GSS HSPA14	1.53e-03	12	145	2	C0026636
Disease	smoking status measurement	CYP2A6 COL16A1 VTI1A REV3L AGBL4 TNNI3K PXDNL SETBP1 CTNNA2 CDH1 SDK1 CDH12 SMG6 EPHB1	1.78e-03	1160	145	14	EFO_0006527
Disease	3-hydroxy-1-methylpropylmercapturic acid measurement	DOCK1 VTI1A ITGA4 KCNJ2 SEC11A CTNNA2 TRIM36	1.84e-03	352	145	7	EFO_0007015
Disease	metabolite measurement	FAM47A CYP2A6 CYP2C8 SPTA1 CASP9 GPAM REV3L SLC1A4 EPHB1	1.86e-03	560	145	9	EFO_0004725
Disease	interferon gamma measurement	EPHB2 EFCAB13 ARFGEF1	2.04e-03	51	145	3	EFO_0008165
Disease	Tobacco Dependence	CYP2A6 PLEKHG1	2.10e-03	14	145	2	C0040332
Disease	Nicotine Dependence	CYP2A6 PLEKHG1	2.10e-03	14	145	2	C0028043
Disease	T wave morphology measurement	OLFML2B SCN5A	2.10e-03	14	145	2	EFO_0008398
Disease	familial atrial fibrillation (is_implicated_in)	KCNJ2 SCN5A	2.10e-03	14	145	2	DOID:0050650 (is_implicated_in)
Disease	Nicotine Use Disorder	CYP2A6 PLEKHG1	2.10e-03	14	145	2	C0376384
Disease	acute graft vs. host disease, donor genotype effect measurement	SLC25A24 SDK1	2.41e-03	15	145	2	EFO_0004599, EFO_0007892
Disease	caffeine measurement	LAMB2 STK39	2.41e-03	15	145	2	EFO_0021177
Disease	tumor necrosis factor beta measurement	EPHB2 NAALADL2	2.41e-03	15	145	2	EFO_0008308
Disease	executive function measurement	COL6A3 ARFGEF2 PLEKHG1 RAPGEF2 TRIM36 SDK1 EPHB1	2.65e-03	376	145	7	EFO_0009332
Disease	Cannabis use	SDK1 SMG6	2.75e-03	16	145	2	EFO_0007585
Disease	behavioural inhibitory control measurement	GPAM EFR3A	2.75e-03	16	145	2	EFO_0008467
Disease	cholesterol in IDL measurement	EFCAB13 GPAM ABCA6	2.94e-03	58	145	3	EFO_0021899
Disease	bacterial pathogen genotype measurement, pulmonary tuberculosis	FSTL5 RIMS3	3.11e-03	17	145	2	EFO_0010271, EFO_1000049
Disease	uric acid measurement	FAT4 EFCAB13 INSRR GPATCH2 NSD3 ABCA6 SETBP1 AKAP13 SESN2	3.29e-03	610	145	9	EFO_0004761
Disease	free cholesterol in IDL measurement	EFCAB13 GPAM ABCA6	3.40e-03	61	145	3	EFO_0022181
Disease	cerebral microbleeds	CARS1 CTNNA2	3.88e-03	19	145	2	EFO_0010059
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7	3.88e-03	19	145	2	EFO_0007872
Disease	tuberculosis	FAM47A CYP2A6 CYP2C8 PXDNL PCDH11X	4.37e-03	216	145	5	MONDO_0018076
Disease	interstitial lung disease	AKAP13 MUC5AC UMAD1	4.42e-03	67	145	3	EFO_0004244
Disease	skin hydration measurement	PKD1L1 PLEKHG1	4.74e-03	21	145	2	EFO_0009586
Disease	smoking behaviour measurement	COL16A1 REV3L AGBL4 TNNI3K SDK1	4.90e-03	222	145	5	EFO_0005671

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDDRADALQAGASQF	VAMP3	46	Q15836
ADGFVLLGDTTDEQR	UMAD1	21	C9J7I0
RSEDITGQLGNNDDL	SMG6	1341	Q86US8
FFGDGRSTDIQEEAL	AARD	36	Q4LEZ3
AAGENRLGTDESKFN	ANXA11	366	P50995
LSEIQGEVLSFDGNR	BAG5	376	Q9UL15
DRNGSGTLDLEEFLR	CAPS	156	Q13938
LVDQAEEFSGRGEQA	CYP2A6	91	P11509
GQQFLLEEGDFEDSN	CRYBG3	2536	Q68DQ2
SLELRAQGQDGDFVS	COL16A1	141	Q07092
ERLDSTQVGEFLGDN	ARFGEF1	741	Q9Y6D6
FRADDGGLTEQSVAQ	COPZ2	181	Q9P299
DLGDNGTVRFSLQEA	FAT4	611	Q6V0I7
LEVDDFENRNGTDGL	ABCA6	931	Q8N139
ERFENSNIGTAGASD	AKAP13	506	Q12802
ERLDSTQVGDFLGDS	ARFGEF2	686	Q9Y6D5
ALIDNGEEFSGRGNS	CYP2C8	86	P10632
NSFDDRFLVTAGADG	CFAP44	866	Q96MT7
RLSVEFEANDLQGGS	EFR3A	346	Q14156
DLFLARRGSDTNVDG	CCDC27	171	Q2M243
ALEDSRSQEGANGEA	RABEP2	21	Q9H5N1
GNGAITFEELRDELQ	NOX5	181	Q96PH1
DQIDINVGFDSGIDR	KCNJ2	246	P63252
AADESFSQVDFGGRL	EPHB1	141	P54762
RFSLEGASDADIGTN	PCDHA3	151	Q9Y5H8
DGEDFNLGDALDSSN	KRT18	386	P05783
ESGAGLTRFQAEASE	MAGED2	6	Q9UNF1
GGASELQEDESFTLR	LLGL2	106	Q6P1M3
AFENGRALVELSGNS	GMIP	601	Q9P107
SGVFLNNASGREKDE	DST	2046	Q03001
DSNFAGDLVRNLEGA	DDX42	606	Q86XP3
DNLALRDGQEGITAF	ECHDC3	276	Q96DC8
IAADESFSQVDLGGR	EPHB2	141	P29323
SEDLLDVDTAAGGFQ	FBXO3	171	Q9UK99
RAFASSELSNVDGGD	KIAA0232	896	Q92628
EISAGDEGEFRQSNN	CUL7	391	Q14999
ISDQEALDVFLNSGG	DTNBP1	246	Q96EV8
DEAELNLREQDGFTG	NES	976	P48681
LLGDSTNSGEERDQF	LRCH1	386	Q9Y2L9
SGGDAAALERQATFE	LAMB2	731	P55268
SQDAARKFEDGNLGT	GOLGA6L2	121	Q8N9W4
GDNGDFTLRLEDVSQ	LAG3	311	P18627
IDGFDDLGSVLNNDT	NLRP5	361	P59047
GTDSGDFDTLENLRA	MUC5AC	1401	P98088
NGGDFDTFQNLRDEG	MUC5AC	1971	P98088
VGGNTRDLFAIDQET	PCDH11X	716	Q9BZA7
RGSGTASDDEFENLR	HUWE1	1901	Q7Z6Z7
VRNGGSFEDDLSLGA	ITPRID2	106	P28290
NLDLEDINDFGDDGS	FSTL5	291	Q8N475
RGNDETIGFEDILND	POMP	106	Q9Y244
ARFTLPNAQDDDEGS	PCDHAC1	141	Q9H158
FQALGSEGQEDLSDR	MYO15B	281	Q96JP2
ALFSILDQDSGDNGR	PCDHB14	366	Q9Y5E9
LGDIFRETGDNFSDV	P2RX7	231	Q99572
QGRQAGDDFVESSIL	PXDNL	601	A1KZ92
LEDSIDNLSQNGEGR	PUS10	76	Q3MIT2
LLQDQGSGLSSRFEE	CBY2	296	Q8NA61
ARLSDSGEFSAEAGN	IGSF22	391	Q8N9C0
ELDCFNTGRGRETQD	BCLAF3	321	A2AJT9
LVDQAEEFSGRGEQA	CYP2A13	91	Q16696
DARGADELSLQIGDT	DOCK1	21	Q14185
TGIGELAAALNEFDN	CTNNA2	271	P26232
EGSLLEENFGDSLQS	FBXO5	161	Q9UKT4
LVDQAEEFSGRGEQA	CYP2A7	91	P20853
INTAQEFDGSDSGAR	DHPS	306	P49366
FGDVGALESLRGNAD	CASP9	136	P55211
ALDTSEGVNQDTFGR	COL6A3	2406	P12111
NGEDAGVQLSDFSLI	IFIH1	426	Q9BYX4
ESGNLGRVDQVSEFE	AGBL4	51	Q5VU57
SGLDEQGEAREAFLN	CADM4	361	Q8NFZ8
EGFLAALTTANQDGR	DDX12P	586	Q92771
TDGIDLARDSEGFNS	CCP110	156	O43303
AEENIDLLDDGSNSF	EFCAB13	11	Q8IY85
LSGIALNDRNEFSGD	ECM2	166	O94769
GELSFGNDVRTLQAD	FAM43A	361	Q8N2R8
ARFGESIVNLGDIDN	ITGA4	366	P13612
LRLGGNSSDFEIQED	INSRR	751	P14616
GDLGADEESIRNLFD	FAM47A	616	Q5JRC9
GASEQALSAQEGFER	LAMB3	1066	Q13751
GEEDTQAFDIGALRN	CDH12	666	P55289
ALDQFTLASFGEGDR	FRY	2641	Q5TBA9
AFSADALRTGGQELE	FAM30A	36	Q9NZY2
TDAGLFTNDEGRQGD	GPATCH2	266	Q9NW75
GSLDQDRRLFVDGQE	GSS	246	P48637
EESVTLDNGGFAALE	SDK1	2051	Q7Z5N4
FGEEDGLDNRRNKTT	PKD1L1	1561	Q8TDX9
GEEDQDFDLSQLHRG	CDH1	761	P12830
ADENSDGRQQILSLG	MPHOSPH8	521	Q99549
AVFSVSDLDSGDNGR	PCDHB3	366	Q9Y5E6
RGLLDQNGFTADDIN	HSPA14	316	Q0VDF9
LGVEDTLDGQQDSFL	MAP3K1	871	Q13233
NDAGEVRLADFGISA	MAP4K1	146	Q92918
EGQLGLGDTEERNTF	RPGR	116	Q92834
FDRNSESNDLNGLDD	RTTN	1511	Q86VV8
LNNSGGFESARDVEA	SESN2	246	P58004
QLSGREEQSSDAGLF	RBM6	371	P78332
AFGSLNDENTDGAID	SLC4A11	376	Q8NBS3
LLTLDDSFNDVGSDN	TRIM36	61	Q9NQ86
LRTQEGEGAGADEFL	RIN1	526	Q13671
ALQEGEGDLSISADR	CARS1	296	P49589
QRLDLSGNEIEAFSG	LRRTM3	256	Q86VH5
TRLGAESQFSDFLDG	RIMS3	126	Q9UJD0
VADSGLDSRELNFGS	NARS2	76	Q96I59
VLARDFDLGFSGNSE	GPAM	516	Q9HCL2
AGEQGTQDITDASER	NCAN	21	O14594
FLFRQQAGSGLSEED	SCN5A	1926	Q14524
EDSVLFRRGTGQSDD	SMN1	16	Q16637
DVASDGDFLIFEGNR	SUPT5H	351	O00267
QEDSDIAFLIDGSGS	ITGAM	146	P11215
ELLNQLDGFDSRGDV	PSMC1	311	P62191
ADILAGREDNSGSDV	SLC35F2	181	Q8IXU6
QQDEFFSGDNGVDLL	OLFML2B	316	Q68BL8
QNVADFRDAGGSLTE	MSANTD4	126	Q8NCY6
EAATQAEDSGLRLDG	SRPK3	296	Q9UPE1
GREENAGAEAAQSLS	TASOR	56	Q9UK61
SLAIGLDDGTADQQR	ZBTB25	171	P24278
LISLGADRDATNDDG	PPP1R27	116	Q86WC6
QDQGDRASLDAADSG	RAPGEF2	1231	Q9Y4G8
QAHRNFLEDGESDGF	TMEM59	216	Q9BXS4
ASASGAQRGSLEEFE	ZC3H3	136	Q8IXZ2
SQRDVFGNGISNDEE	ZNF77	56	Q15935
GQALRSEEFSAGGEL	TTBK1	946	Q5TCY1
SQRIAEEALGGLDNS	ZSCAN30	221	Q86W11
TRLANDLAEFEGDFS	REV3L	1931	O60673
VDSNDLERQGLLSGA	SPNS3	491	Q6ZMD2
IGSTRDADENEFLGN	GTF2A1L	361	Q9UNN4
GSEGEDLIRFFNSLN	SLC1A4	241	P43007
LTFEQDIERGNTDGL	SEMA6A	551	Q9H2E6
GEGQLESFSQERDLN	ZNF774	126	Q6NX45
SDEVRNELLGDDGNS	VTI1A	96	Q96AJ9
ELQDQEFGKRDSLGT	TNKS1BP1	861	Q9C0C2
QDDELSLRALQATGG	UBL7	351	Q96S82
ELFESGEDREVNNGL	USP25	941	Q9UHP3
FLTKGDNNAVDDRGL	SEC11A	111	P67812
EAFLENEDLGNSLGS	SPTA1	496	P02549
EDGESFGQGRDRSSL	TBCK	361	Q8TEA7
IQNGRELFESSLCGD	NSD3	161	Q9BZ95
TSNEAARDFGGAVQD	THUMPD3	241	Q9BV44
DGFSLQLDESADVSG	ZBED5	271	Q49AG3
SLDQFVRGEVLEGSN	USP24	1841	Q9UPU5
GFTDEQLGDLGLEQF	PIEZO1	661	Q92508
LGTEERSALFGNIQD	PLEKHG1	151	Q9ULL1
NALDGLEETGRFSSF	TRAV1-1	66	A0A0B4J248
EDLEQFLGTSERQGR	VPS9D1	381	Q9Y2B5
RDTADGVSQELFSAG	STK39	476	Q9UEW8
DELGSGRDVDSNSNA	SETBP1	61	Q9Y6X0
LGSDSEANGFAERRI	TBC1D10A	41	Q9BXI6
DFGESRFLQSLDEDN	TNNI3K	606	Q59H18
ESGQFSDGLEDRGLL	TMEM163	56	Q8TC26
TLFQALDRNGDGVVD	SLC25A24	26	Q6NUK1
SLSEGLFNAFDENRD	USP32	231	Q8NFA0
LEESGFDQFQLDGAE	NAALADL2	56	Q58DX5