Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	prostaglandin-endoperoxide synthase activity	PTGS1 PTGS2	1.50e-06	2	25	2	GO:0004666
GeneOntologyMolecularFunction	peroxidase activity	PXDN PTGS1 PTGS2	7.19e-05	65	25	3	GO:0004601
GeneOntologyMolecularFunction	oxidoreductase activity, acting on peroxide as acceptor	PXDN PTGS1 PTGS2	7.88e-05	67	25	3	GO:0016684
GeneOntologyMolecularFunction	olfactory receptor activity	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	1.70e-04	431	25	5	GO:0004984
GeneOntologyMolecularFunction	antioxidant activity	PXDN PTGS1 PTGS2	2.36e-04	97	25	3	GO:0016209
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	PTGS1 PTGS2	4.44e-04	25	25	2	GO:0016702
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	PTGS1 PTGS2	4.80e-04	26	25	2	GO:0016701
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR52A5 OR52A1 CNR2 OR52N2 OR52E8 OR52N4	6.35e-04	884	25	6	GO:0004930
GeneOntologyMolecularFunction	heme binding	PXDN PTGS1 PTGS2	9.13e-04	154	25	3	GO:0020037
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR52A5 IL17RD OR52A1 CNR2 OR52N2 OR52E8 OR52N4	1.05e-03	1353	25	7	GO:0004888
GeneOntologyMolecularFunction	tetrapyrrole binding	PXDN PTGS1 PTGS2	1.10e-03	164	25	3	GO:0046906
GeneOntologyMolecularFunction	dioxygenase activity	PTGS1 PTGS2	6.65e-03	98	25	2	GO:0051213
GeneOntologyBiologicalProcess	cyclooxygenase pathway	PTGS1 PTGS2	7.71e-05	11	25	2	GO:0019371
GeneOntologyBiologicalProcess	regulation of muscle contraction	ANK2 SETD3 PTGS1 PTGS2	9.61e-05	202	25	4	GO:0006937
GeneOntologyBiologicalProcess	regulation of smooth muscle contraction	SETD3 PTGS1 PTGS2	1.17e-04	79	25	3	GO:0006940
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	1.48e-04	432	25	5	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	2.09e-04	465	25	5	GO:0007608
GeneOntologyBiologicalProcess	cellular oxidant detoxification	PXDN PTGS1 PTGS2	2.35e-04	100	25	3	GO:0098869
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	2.53e-04	485	25	5	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	3.62e-04	524	25	5	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	4.41e-04	547	25	5	GO:0007606
GeneOntologyBiologicalProcess	cellular detoxification	PXDN PTGS1 PTGS2	4.75e-04	127	25	3	GO:1990748
GeneOntologyBiologicalProcess	regulation of muscle system process	ANK2 SETD3 PTGS1 PTGS2	5.37e-04	317	25	4	GO:0090257
GeneOntologyBiologicalProcess	smooth muscle contraction	SETD3 PTGS1 PTGS2	5.43e-04	133	25	3	GO:0006939
GeneOntologyBiologicalProcess	regulation of brown fat cell differentiation	FLCN PTGS2	5.61e-04	29	25	2	GO:0090335
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	5.85e-04	582	25	5	GO:0050906
GeneOntologyBiologicalProcess	cellular response to toxic substance	PXDN PTGS1 PTGS2	6.18e-04	139	25	3	GO:0097237
GeneOntologyBiologicalProcess	prostaglandin biosynthetic process	PTGS1 PTGS2	8.66e-04	36	25	2	GO:0001516
GeneOntologyBiologicalProcess	positive regulation of smooth muscle contraction	PTGS1 PTGS2	8.66e-04	36	25	2	GO:0045987
GeneOntologyBiologicalProcess	prostanoid biosynthetic process	PTGS1 PTGS2	8.66e-04	36	25	2	GO:0046457
GeneOntologyBiologicalProcess	detoxification	PXDN PTGS1 PTGS2	1.11e-03	170	25	3	GO:0098754
GeneOntologyBiologicalProcess	maintenance of blood-brain barrier	PTGS1 PTGS2	1.18e-03	42	25	2	GO:0035633
GeneOntologyBiologicalProcess	muscle contraction	ANK2 SETD3 PTGS1 PTGS2	1.28e-03	400	25	4	GO:0006936
MousePheno	decreased urine prostaglandin level	PTGS1 PTGS2	3.68e-06	3	16	2	MP:0011564
MousePheno	abnormal urine prostaglandin level	PTGS1 PTGS2	1.23e-05	5	16	2	MP:0011562
MousePheno	disorganized secondary lens fibers	PXDN ANK2	8.05e-05	12	16	2	MP:0002579
MousePheno	increased prostaglandin level	PTGS1 PTGS2	9.51e-05	13	16	2	MP:0009814
MousePheno	decreased prostaglandin level	PTGS1 PTGS2	9.51e-05	13	16	2	MP:0009815
MousePheno	allodynia	PTGS1 PTGS2	1.28e-04	15	16	2	MP:0003177
MousePheno	abnormal stomach pH	PTGS1 PTGS2	2.08e-04	19	16	2	MP:0008004
MousePheno	abnormal response of heart to induced stress	ANK2 PTGS1 PTGS2	2.40e-04	109	16	3	MP:0004484
MousePheno	abnormal renal glomerular filtration rate	PTGS1 PTGS2	3.63e-04	25	16	2	MP:0002847
MousePheno	abnormal prostaglandin level	PTGS1 PTGS2	3.93e-04	26	16	2	MP:0009811
MousePheno	increased susceptibility to weight gain	ANK2 PTGS2 CSPG4	4.12e-04	131	16	3	MP:0005455
MousePheno	increased susceptibility to age related obesity	ANK2 CSPG4	4.24e-04	27	16	2	MP:0003212
MousePheno	abnormal renal glomerular filtration	PTGS1 PTGS2	4.90e-04	29	16	2	MP:0013284
MousePheno	decreased susceptibility to induced thrombosis	PTGS1 PTGS2	5.24e-04	30	16	2	MP:0031120
MousePheno	abnormal keratinocyte differentiation	PTGS1 PTGS2	5.24e-04	30	16	2	MP:0002656
MousePheno	increased epididymal fat pad weight	ANK2 CSPG4	5.97e-04	32	16	2	MP:0009288
MousePheno	abnormal parturition	SETD3 PTGS1	6.35e-04	33	16	2	MP:0002907
MousePheno	abnormal uterine environment	PTGS1 PTGS2	7.15e-04	35	16	2	MP:0004014
MousePheno	decreased susceptibility to autoimmune disorder	NLRP10 PTGS1 PTGS2	1.04e-03	180	16	3	MP:0005351
MousePheno	abnormal nociception after inflammation	PTGS1 PTGS2	1.13e-03	44	16	2	MP:0002736
MousePheno	enlarged cecum	PTGS1 CNR2	1.29e-03	47	16	2	MP:0009476
MousePheno	abnormal lens fiber morphology	PXDN ANK2	1.40e-03	49	16	2	MP:0002840
Domain	PEROXIDASE_3	PXDN PTGS1 PTGS2	2.53e-07	10	25	3	PS50292
Domain	Haem_peroxidase	PXDN PTGS1 PTGS2	2.53e-07	10	25	3	IPR010255
Domain	-	PXDN PTGS1 PTGS2	2.53e-07	10	25	3	1.10.640.10
Domain	Haem_peroxidase_animal	PXDN PTGS1 PTGS2	2.53e-07	10	25	3	IPR019791
Domain	An_peroxidase	PXDN PTGS1 PTGS2	2.53e-07	10	25	3	PF03098
Domain	ELM2	RCOR3 RCOR1	1.33e-04	13	25	2	PF01448
Domain	ELM2	RCOR3 RCOR1	1.33e-04	13	25	2	PS51156
Domain	ELM2_dom	RCOR3 RCOR1	1.33e-04	13	25	2	IPR000949
Domain	ELM2	RCOR3 RCOR1	1.33e-04	13	25	2	SM01189
Domain	Olfact_rcpt	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	1.51e-04	393	25	5	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR52A5 OR52A1 CNR2 OR52N2 OR52E8 OR52N4	2.06e-04	670	25	6	IPR017452
Domain	7tm_1	OR52A5 OR52A1 CNR2 OR52N2 OR52E8 OR52N4	2.18e-04	677	25	6	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR52A5 OR52A1 CNR2 OR52N2 OR52E8 OR52N4	2.32e-04	685	25	6	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR52A5 OR52A1 CNR2 OR52N2 OR52E8 OR52N4	2.43e-04	691	25	6	PS50262
Domain	GPCR_Rhodpsn	OR52A5 OR52A1 CNR2 OR52N2 OR52E8 OR52N4	2.45e-04	692	25	6	IPR000276
Domain	SANT_dom	RCOR3 RCOR1	5.48e-04	26	25	2	IPR017884
Domain	SANT	RCOR3 RCOR1	6.36e-04	28	25	2	PS51293
Domain	Myb_DNA-binding	RCOR3 RCOR1	9.96e-04	35	25	2	PF00249
Domain	MYB_LIKE	RCOR3 RCOR1	1.17e-03	38	25	2	PS50090
Domain	SANT	RCOR3 RCOR1	2.03e-03	50	25	2	SM00717
Domain	SANT/Myb	RCOR3 RCOR1	2.19e-03	52	25	2	IPR001005
Domain	-	NLRP10 ANK2	6.83e-03	93	25	2	1.10.533.10
Domain	DEATH-like_dom	NLRP10 ANK2	7.71e-03	99	25	2	IPR011029
Domain	7TM_GPCR_Srsx	OR52A5 CNR2	9.77e-03	112	25	2	SM01381
Domain	EGF	PTGS1 PTGS2	1.22e-02	126	25	2	PF00008
Pathway	BIOCARTA_ACETAMINOPHEN_PATHWAY	PTGS1 PTGS2	1.54e-05	5	18	2	M22024
Pathway	BIOCARTA_ACETAMINOPHEN_PATHWAY	PTGS1 PTGS2	4.29e-05	8	18	2	MM1547
Pathway	WP_ACETAMINOPHEN_IN_ANALGESIA_AND_ANTIPYRESIS	PTGS1 PTGS2	5.51e-05	9	18	2	M48307
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	9.93e-05	389	18	5	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	1.38e-04	417	18	5	M4072
Pathway	REACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX	PTGS1 PTGS2	1.60e-04	15	18	2	MM14870
Pathway	REACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX	PTGS1 PTGS2	1.60e-04	15	18	2	M27149
Pathway	WP_OVERVIEW_OF_NANOPARTICLE_EFFECTS	PTGS1 PTGS2	2.60e-04	19	18	2	M39473
Pathway	WP_ASPIRIN_AND_MIRNAS	PTGS1 PTGS2	2.60e-04	19	18	2	M48319
Pathway	BIOCARTA_EICOSANOID_PATHWAY	PTGS1 PTGS2	2.89e-04	20	18	2	MM1529
Pathway	WP_EICOSANOID_SYNTHESIS	PTGS1 PTGS2	3.50e-04	22	18	2	MM15961
Pathway	BIOCARTA_EICOSANOID_PATHWAY	PTGS1 PTGS2	3.50e-04	22	18	2	M22003
Pathway	WP_EICOSANOID_SYNTHESIS	PTGS1 PTGS2	3.83e-04	23	18	2	M39382
Pathway	WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5122	PTGS1 PTGS2	7.01e-04	31	18	2	M42531
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX	PTGS1 PTGS2	7.01e-04	31	18	2	M39851
Pathway	WP_PROSTAGLANDIN_SYNTHESIS_AND_REGULATION	PTGS1 PTGS2	7.47e-04	32	18	2	MM15850
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX	PTGS1 PTGS2	7.94e-04	33	18	2	MM15918
Pathway	WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5321	PTGS1 PTGS2	8.43e-04	34	18	2	M48061
Pathway	REACTOME_SENSORY_PERCEPTION	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	9.65e-04	636	18	5	M41834
Pathway	WP_PROSTAGLANDIN_SYNTHESIS_AND_REGULATION	PTGS1 PTGS2	1.48e-03	45	18	2	M39355
Pathway	WP_OMEGA6FATTY_ACIDS_IN_SENESCENCE	PTGS1 PTGS2	2.36e-03	57	18	2	M48332
Pathway	KEGG_ARACHIDONIC_ACID_METABOLISM	PTGS1 PTGS2	2.44e-03	58	18	2	M5410
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	PTGS1 PTGS2	2.52e-03	59	18	2	M27140
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	PTGS1 PTGS2	2.70e-03	61	18	2	MM14861
Pathway	WP_SELENIUM_MICRONUTRIENT_NETWORK	PTGS1 PTGS2	5.28e-03	86	18	2	M39385
Pathway	WP_OXIDATIVE_STRESS_AND_REDOX_PATHWAY	PTGS1 PTGS2	6.02e-03	92	18	2	MM15823
Pubmed	Endogenous cyclo-oxygenase activity regulates mouse gastric surface pH.	PTGS1 PTGS2	4.96e-07	2	25	2	12411530
Pubmed	Localization of prostaglandin-H synthase-1 and -2 in mouse skin: implications for cutaneous function.	PTGS1 PTGS2	4.96e-07	2	25	2	9665805
Pubmed	Expression of the two isoforms of prostaglandin endoperoxide synthase (PGHS-1 and PGHS-2) during adipose cell differentiation.	PTGS1 PTGS2	4.96e-07	2	25	2	9256365
Pubmed	Cyclooxygenase-2 is expressed in bladder during fetal development and stimulated by outlet obstruction.	PTGS1 PTGS2	4.96e-07	2	25	2	9362331
Pubmed	Structural determination and promoter analysis of the chicken mitogen-inducible prostaglandin G/H synthase gene and genetic mapping of the murine homolog.	PTGS1 PTGS2	4.96e-07	2	25	2	8424659
Pubmed	Immunohistochemical and ultrastructural localization of prostaglandin H synthase in the preimplantation mouse embryo.	PTGS1 PTGS2	4.96e-07	2	25	2	8882280
Pubmed	Role of COX-1 and COX-2 on skin PGs biosynthesis by mechanical scratching in mice.	PTGS1 PTGS2	4.96e-07	2	25	2	16815697
Pubmed	An immunohistochemical survey of nine cases of medullary carcinoma of thyroid including reactivity for Cox-1 and Cox-2 enzymes.	PTGS1 PTGS2	4.96e-07	2	25	2	12665651
Pubmed	An imbalance of COX level is not related to placental abruption.	PTGS1 PTGS2	4.96e-07	2	25	2	21561892
Pubmed	A novel anti-atherogenic role for COX-2--potential mechanism for the cardiovascular side effects of COX-2 inhibitors.	PTGS1 PTGS2	4.96e-07	2	25	2	17643885
Pubmed	Differential expression of cyclooxygenases in hypertrophic scar and keloid tissues.	PTGS1 PTGS2	4.96e-07	2	25	2	19769727
Pubmed	Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1.	PTGS1 PTGS2	4.96e-07	2	25	2	19433337
Pubmed	Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response.	PTGS1 PTGS2	4.96e-07	2	25	2	27845343
Pubmed	Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair.	PTGS1 PTGS2	4.96e-07	2	25	2	12045254
Pubmed	Ocular prostaglandin production and morphology in mice lacking a single isoform of cyclooxygenase.	PTGS1 PTGS2	4.96e-07	2	25	2	19767186
Pubmed	Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.	PTGS1 PTGS2	4.96e-07	2	25	2	10487525
Pubmed	Multiple female reproductive failures in cyclooxygenase 2-deficient mice.	PTGS1 PTGS2	4.96e-07	2	25	2	9346237
Pubmed	Analysis of renal immunoexpression of cyclooxygenase-1 and cyclooxygenase-2 in lupus and nonlupus membranous glomerulopathy.	PTGS1 PTGS2	4.96e-07	2	25	2	18459455
Pubmed	Placental tissue cyclo-oxygenase 1 and 2 in pre-eclamptic and normal pregnancy.	PTGS1 PTGS2	4.96e-07	2	25	2	16930602
Pubmed	Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns.	PTGS1 PTGS2	4.96e-07	2	25	2	23742950
Pubmed	Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic fibrosis patients.	PTGS1 PTGS2	4.96e-07	2	25	2	20720307
Pubmed	The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy.	PTGS1 PTGS2	4.96e-07	2	25	2	19887674
Pubmed	Cyclooxygenase in normal human tissues--is COX-1 really a constitutive isoform, and COX-2 an inducible isoform?	PTGS1 PTGS2	4.96e-07	2	25	2	18657230
Pubmed	Panax quinquefolium saponin combined with dual antiplatelet drugs inhibits platelet adhesion to injured HUVECs via PI3K/AKT and COX pathways.	PTGS1 PTGS2	4.96e-07	2	25	2	27401285
Pubmed	Cyclo-oxygenase 2 function is essential for bone fracture healing.	PTGS1 PTGS2	4.96e-07	2	25	2	12054171
Pubmed	Cyclooxygenase-1, but not -2, is upregulated in NB4 leukemic cells and human primary promyelocytic blasts during differentiation.	PTGS1 PTGS2	4.96e-07	2	25	2	15190260
Pubmed	Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2.	PTGS1 PTGS2	4.96e-07	2	25	2	12958020
Pubmed	Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma.	PTGS1 PTGS2	4.96e-07	2	25	2	19205707
Pubmed	Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients.	PTGS1 PTGS2	4.96e-07	2	25	2	26081267
Pubmed	Glutathione promotes prostaglandin H synthase (cyclooxygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2α.	PTGS1 PTGS2	4.96e-07	2	25	2	22982857
Pubmed	Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality.	PTGS1 PTGS2	4.96e-07	2	25	2	17110378
Pubmed	Distinct expression of cyclooxygenase-1 and -2 in the human thymus.	PTGS1 PTGS2	4.96e-07	2	25	2	11981837
Pubmed	Critical role of COX-1 in prostacyclin production by human endothelial cells under modification of hydroperoxide tone.	PTGS1 PTGS2	4.96e-07	2	25	2	18838483
Pubmed	Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells.	PTGS1 PTGS2	4.96e-07	2	25	2	8071353
Pubmed	Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions.	PTGS1 PTGS2	4.96e-07	2	25	2	29676940
Pubmed	Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse.	PTGS1 PTGS2	4.96e-07	2	25	2	10944235
Pubmed	Variation in cyclooxygenase expression levels within the colorectum.	PTGS1 PTGS2	4.96e-07	2	25	2	12720297
Pubmed	Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2.	PTGS1 PTGS2	4.96e-07	2	25	2	8181472
Pubmed	Expanding the febrigenic role of cyclooxygenase-2 to the previously overlooked responses.	PTGS1 PTGS2	4.96e-07	2	25	2	16081878
Pubmed	Human cyclooxygenase-2 cDNA.	PTGS1 PTGS2	4.96e-07	2	25	2	1380156
Pubmed	Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide.	PTGS1 PTGS2	4.96e-07	2	25	2	11694451
Pubmed	Cyclooxygenase-1 and cyclooxygenase-2 in the mouse ductus arteriosus: individual activity and functional coupling with nitric oxide synthase.	PTGS1 PTGS2	4.96e-07	2	25	2	12922938
Pubmed	Distinct roles for cyclooxygenases 1 and 2 in interleukin-1-induced behavioral changes.	PTGS1 PTGS2	4.96e-07	2	25	2	12183660
Pubmed	Comparative analysis of pharmacologic and/or genetic disruption of cyclooxygenase-1 and cyclooxygenase-2 function in female reproduction in mice.	PTGS1 PTGS2	4.96e-07	2	25	2	11416042
Pubmed	The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(-/-), but not in cyclooxygenase-1(-/-) mice.	PTGS1 PTGS2	4.96e-07	2	25	2	10216176
Pubmed	Coupling between cyclooxygenases and terminal prostanoid synthases.	PTGS1 PTGS2	4.96e-07	2	25	2	16140261
Pubmed	Effects of Cyclooxygenase on the Urothelium of the Urinary Bladder of Mice Exposed to Pelvic Radiation.	PTGS1 PTGS2	4.96e-07	2	25	2	27386631
Pubmed	Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.	PTGS1 PTGS2	4.96e-07	2	25	2	12163371
Pubmed	Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein.	PTGS1 PTGS2	4.96e-07	2	25	2	15263079
Pubmed	Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts.	PTGS1 PTGS2	4.96e-07	2	25	2	10449516
Pubmed	Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II.	PTGS1 PTGS2	4.96e-07	2	25	2	12093889
Pubmed	Genetic model of selective COX2 inhibition reveals novel heterodimer signaling.	PTGS1 PTGS2	4.96e-07	2	25	2	16732282
Pubmed	COX-2 inhibition attenuates anorexia during systemic inflammation without impairing cytokine production.	PTGS1 PTGS2	4.96e-07	2	25	2	11832369
Pubmed	Altered monocyte cyclooxygenase response to lipopolysaccharide in type 1 diabetes.	PTGS1 PTGS2	4.96e-07	2	25	2	17130490
Pubmed	Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox.	PTGS1 PTGS2	4.96e-07	2	25	2	31510878
Pubmed	Expression of cyclooxygenase isoforms in developing rat placenta, human term placenta, and BeWo human trophoblast model.	PTGS1 PTGS2	4.96e-07	2	25	2	16323955
Pubmed	Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.	PTGS1 PTGS2	4.96e-07	2	25	2	7510883
Pubmed	Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study.	PTGS1 PTGS2	4.96e-07	2	25	2	17495879
Pubmed	Disruption of cyclooxygenase genes in mice.	PTGS1 PTGS2	4.96e-07	2	25	2	8994299
Pubmed	Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population.	PTGS1 PTGS2	4.96e-07	2	25	2	31735164
Pubmed	Prostaglandin endoperoxide synthase gene structure: identification of the transcriptional start site and 5'-flanking regulatory sequences.	PTGS1 PTGS2	4.96e-07	2	25	2	1536575
Pubmed	Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis.	PTGS1 PTGS2	4.96e-07	2	25	2	16787416
Pubmed	Both constitutive and inducible prostaglandin H synthase affect dermal wound healing in mice.	PTGS1 PTGS2	4.96e-07	2	25	2	12118094
Pubmed	Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model.	PTGS1 PTGS2	4.96e-07	2	25	2	19523994
Pubmed	Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies.	PTGS1 PTGS2	4.96e-07	2	25	2	23850620
Pubmed	Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus.	PTGS1 PTGS2	4.96e-07	2	25	2	12189249
Pubmed	Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids.	PTGS1 PTGS2	4.96e-07	2	25	2	9156514
Pubmed	Catalytically inactive cyclooxygenase 2 and absence of prostaglandin E2 biosynthesis in murine peritoneal macrophages following in vivo phagocytosis of heat-killed Mycobacterium bovis bacillus Calmette-Guérin.	PTGS1 PTGS2	4.96e-07	2	25	2	17982098
Pubmed	Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.	PTGS1 PTGS2	4.96e-07	2	25	2	29180445
Pubmed	Cyclooxygenase regulates angiogenesis induced by colon cancer cells.	PTGS1 PTGS2	4.96e-07	2	25	2	9630216
Pubmed	Host cyclooxygenase-2 modulates carcinoma growth.	PTGS1 PTGS2	4.96e-07	2	25	2	10841517
Pubmed	Cyclooxygenase enzyme expression and E series prostaglandin receptor signalling are enhanced in heavy menstruation.	PTGS1 PTGS2	4.96e-07	2	25	2	17264103
Pubmed	Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain.	PTGS1 PTGS2	4.96e-07	2	25	2	17266762
Pubmed	Cyclooxygenase polymorphisms in gastric and colorectal carcinogenesis: are conclusive results available?	PTGS1 PTGS2	4.96e-07	2	25	2	19060633
Pubmed	The COX-2 pathway is essential during early stages of skeletal muscle regeneration.	PTGS1 PTGS2	4.96e-07	2	25	2	15084473
Pubmed	Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1beta.	PTGS1 PTGS2	4.96e-07	2	25	2	11489266
Pubmed	Structural modeling and simulation studies of human cyclooxygenase (COX) isozymes with selected terpenes: implications in drug designing and development.	PTGS1 PTGS2	4.96e-07	2	25	2	23668350
Pubmed	Immunohistochemical localization of prostaglandin H synthase in the embryo and uterus of the mouse from ovulation through implantation.	PTGS1 PTGS2	4.96e-07	2	25	2	2109618
Pubmed	Platelet responsiveness to in vitro aspirin is independent of COX-1 and COX-2 protein levels and polymorphisms.	PTGS1 PTGS2	4.96e-07	2	25	2	17631383
Pubmed	Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2.	PTGS1 PTGS2	4.96e-07	2	25	2	16787386
Pubmed	Mucosal expression of cyclooxygenase isoforms 1 and 2 is increased with worsening damage to the gastric mucosa.	PTGS1 PTGS2	4.96e-07	2	25	2	15720413
Pubmed	Suppression of adipogenesis program in cultured preadipocytes transfected stably with cyclooxygenase isoforms.	PTGS1 PTGS2	4.96e-07	2	25	2	19416639
Pubmed	Classification using hierarchical clustering of tumor-infiltrating immune cells identifies poor prognostic ovarian cancers with high levels of COX expression.	PTGS1 PTGS2	4.96e-07	2	25	2	18997734
Pubmed	The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages.	PTGS1 PTGS2	4.96e-07	2	25	2	25645360
Pubmed	COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice.	PTGS1 PTGS2	4.96e-07	2	25	2	12055598
Pubmed	Cyclooxygenase isozymes in oral squamous cell carcinoma:a real-time RT-PCR study with clinic pathological correlations.	PTGS1 PTGS2	4.96e-07	2	25	2	17624243
Pubmed	Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation.	PTGS1 PTGS2	4.96e-07	2	25	2	16518767
Pubmed	Cyclooxygenase-2-dependent oxidative stress mediates palmitate-induced impairment of endothelium-dependent relaxations in mouse arteries.	PTGS1 PTGS2	4.96e-07	2	25	2	25149102
Pubmed	Modulation of the expression and activity of cyclooxygenases in normal and accelerated erythropoiesis.	PTGS1 PTGS2	4.96e-07	2	25	2	15504548
Pubmed	Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae.	PTGS1 PTGS2	4.96e-07	2	25	2	8070358
Pubmed	Imbalanced synthesis of cyclooxygenase-derived thromboxane A2 and prostacyclin compromises vasomotor function of the thoracic aorta in Marfan syndrome.	PTGS1 PTGS2	4.96e-07	2	25	2	17641673
Pubmed	Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs.	PTGS1 PTGS2	4.96e-07	2	25	2	16678543
Pubmed	Role of cyclooxygenases COX-1 and COX-2 in modulating adipogenesis in 3T3-L1 cells.	PTGS1 PTGS2	4.96e-07	2	25	2	12576525
Pubmed	Role of Asn-382 and Thr-383 in activation and inactivation of human prostaglandin H synthase cyclooxygenase catalysis.	PTGS1 PTGS2	4.96e-07	2	25	2	14625295
Pubmed	Celecoxib potentiates the anticancer effect of cisplatin on vulvar cancer cells independently of cyclooxygenase.	PTGS1 PTGS2	4.96e-07	2	25	2	19723114
Pubmed	Platelet response to aspirin in Chinese stroke patients is independent of genetic polymorphisms of COX-1 C50T and COX-2 G765C.	PTGS1 PTGS2	4.96e-07	2	25	2	22972377
Pubmed	Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial cells attenuates inflammatory fever.	PTGS1 PTGS2	4.96e-07	2	25	2	25164664
Pubmed	Compensatory prostaglandin E2 biosynthesis in cyclooxygenase 1 or 2 null cells.	PTGS1 PTGS2	4.96e-07	2	25	2	9463402
Pubmed	An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells.	OR52A5 OR52A1	4.96e-07	2	25	2	10512676
Pubmed	Expression of cyclooxygenase-1 and cyclooxygenase-2 in normal and pathological human oral mucosa.	PTGS1 PTGS2	4.96e-07	2	25	2	21478098
Interaction	PTGIS interactions	PTGS1 PTGS2	2.16e-05	7	21	2	int:PTGIS
Cytoband	11p15.4	NLRP10 OR52A5 OR52N2 OR52E8 OR52N4	7.39e-08	200	25	5	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	NLRP10 OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	4.86e-07	564	25	6	chr11p15
Cytoband	Ensembl 112 genes in cytogenetic band chr1p35	TMEM39B CSMD2	2.54e-03	137	25	2	chr1p35
GeneFamily	Olfactory receptors, family 52	OR52A5 OR52A1 OR52N2 OR52E8 OR52N4	7.16e-10	49	17	5	165
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	RCOR3 RCOR1	1.11e-03	53	17	2	532
Coexpression	GSE10240_IL22_VS_IL17_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_DN	CIAO3 PTGS1 TMEM50B CNR2	3.10e-05	200	24	4	M310
Coexpression	NABA_MATRISOME_HIGHLY_METASTATIC_MELANOMA_TUMOR_CELL_DERIVED	PXDN CSPG4	5.27e-05	12	24	2	M47983
Computational	Neighborhood of MMP1	PXDN PTGS1	6.56e-04	32	13	2	GNF2_MMP1
Computational	Neighborhood of PTX3	PXDN PTGS1	8.31e-04	36	13	2	GNF2_PTX3
Computational	Neighborhood of BAG5	SETD3 TMEM50B	9.26e-04	38	13	2	GCM_BAG5
Computational	Genes in the cancer module 70.	PTGS1 CSPG4	1.19e-03	43	13	2	MODULE_70
Drug	pravadoline	PTGS1 PTGS2 CNR2	9.78e-08	9	25	3	CID000056463
Drug	Tolmetin	PTGS1 PTGS2	1.16e-06	2	25	2	DB00500
Drug	Piroxicam	PTGS1 PTGS2	1.16e-06	2	25	2	DB00554
Drug	Ibuprofen	PTGS1 PTGS2	1.16e-06	2	25	2	DB01050
Drug	Lornoxicam	PTGS1 PTGS2	1.16e-06	2	25	2	DB06725
Drug	N-(3-phenoxy-4-pyridinyl)trifluoromethanesulfonamide	PTGS1 PTGS2	1.16e-06	2	25	2	ctd:C468797
Drug	Fenoprofen	PTGS1 PTGS2	1.16e-06	2	25	2	DB00573
Drug	Ketoprofen	PTGS1 PTGS2	1.16e-06	2	25	2	DB01009
Drug	Tenoxicam	PTGS1 PTGS2	1.16e-06	2	25	2	DB00469
Drug	Ketorolac	PTGS1 PTGS2	1.16e-06	2	25	2	DB00465
Drug	Nabumetone	PTGS1 PTGS2	1.16e-06	2	25	2	DB00461
Drug	AC1O5RN5	PTGS1 PTGS2	1.16e-06	2	25	2	CID006439421
Drug	Tiaprofenic acid	PTGS1 PTGS2	1.16e-06	2	25	2	DB01600
Drug	Acetaminophen	PTGS1 PTGS2	1.16e-06	2	25	2	DB00316
Drug	SC 299	PTGS1 PTGS2	1.16e-06	2	25	2	ctd:C409370
Drug	flosulide	PTGS1 PTGS2	1.16e-06	2	25	2	ctd:C059178
Drug	2-methoxybenzoic acid	PTGS1 PTGS2	1.16e-06	2	25	2	ctd:C081914
Drug	Oxaprozin	PTGS1 PTGS2	1.16e-06	2	25	2	DB00991
Drug	Antrafenine	PTGS1 PTGS2	1.16e-06	2	25	2	DB01419
Drug	Trisalicylate-choline	PTGS1 PTGS2	1.16e-06	2	25	2	DB01401
Drug	Bromfenac	PTGS1 PTGS2	1.16e-06	2	25	2	DB00963
Drug	Antipyrine	PTGS1 PTGS2	1.16e-06	2	25	2	DB01435
Drug	gamma-Homolinolenic acid	PTGS1 PTGS2	1.16e-06	2	25	2	DB00154
Drug	Suprofen	PTGS1 PTGS2	1.16e-06	2	25	2	DB00870
Drug	Diflunisal	PTGS1 PTGS2	1.16e-06	2	25	2	DB00861
Drug	cimicoxib	PTGS1 PTGS2	1.16e-06	2	25	2	CID000213053
Drug	Carprofen	PTGS1 PTGS2	1.16e-06	2	25	2	DB00821
Drug	Meloxicam	PTGS1 PTGS2	1.16e-06	2	25	2	DB00814
Drug	Salsalate	PTGS1 PTGS2	1.16e-06	2	25	2	DB01399
Drug	Salicylate-sodium	PTGS1 PTGS2	1.16e-06	2	25	2	DB01398
Drug	Magnesium salicylate	PTGS1 PTGS2	1.16e-06	2	25	2	DB01397
Drug	Naproxen	PTGS1 PTGS2	1.16e-06	2	25	2	DB00788
Drug	Mefenamic acid	PTGS1 PTGS2	1.16e-06	2	25	2	DB00784
Drug	Maleimides	PTGS1 PTGS2	1.16e-06	2	25	2	ctd:D008301
Drug	Flurbiprofen	PTGS1 PTGS2	1.16e-06	2	25	2	DB00712
Drug	Bismuth Subsalicylate	PTGS1 PTGS2	1.16e-06	2	25	2	DB01294
Drug	Lumiracoxib	PTGS1 PTGS2	1.16e-06	2	25	2	DB01283
Drug	MDL 035	PTGS1 PTGS2	1.16e-06	2	25	2	CID000053454
Drug	tricin	PTGS1 PTGS2	1.16e-06	2	25	2	ctd:C017769
Drug	Nepafenac	PTGS1 PTGS2	1.16e-06	2	25	2	DB06802
Drug	Pyrazoles	PTGS1 PTGS2 CNR2	1.32e-06	20	25	3	ctd:D011720
Drug	5,8,11-eicosatrienoic acid	PTGS1 PTGS2 CNR2	1.78e-06	22	25	3	CID000004028
Drug	17-hydroxy-ent-kaur-15-en-19-oic acid	PTGS1 PTGS2	3.47e-06	3	25	2	CID000169654
Drug	firocoxib	PTGS1 PTGS2	3.47e-06	3	25	2	CID000208910
Drug	itazigrel	PTGS1 PTGS2	3.47e-06	3	25	2	CID000051087
Drug	Meclofenamic acid	PTGS1 PTGS2	3.47e-06	3	25	2	DB00939
Drug	Acetylsalicylic acid	PTGS1 PTGS2	3.47e-06	3	25	2	DB00945
Drug	Salicyclic acid	PTGS1 PTGS2	3.47e-06	3	25	2	DB00936
Drug	malabaricone C	PTGS1 PTGS2	3.47e-06	3	25	2	ctd:C071787
Drug	malabaricone B	PTGS1 PTGS2	3.47e-06	3	25	2	ctd:C071788
Drug	Phenylbutazone	PTGS1 PTGS2	3.47e-06	3	25	2	DB00812
Drug	AHR-10037	PTGS1 PTGS2	3.47e-06	3	25	2	CID000132843
Drug	Etodolac	PTGS1 PTGS2	3.47e-06	3	25	2	DB00749
Drug	nesodine	PTGS1 PTGS2	3.47e-06	3	25	2	CID006475455
Drug	2-propionyloxybenzoic acid	PTGS1 PTGS2	3.47e-06	3	25	2	CID000095938
Drug	1a, 1b-dihomo-PGF2	PTGS1 PTGS2	3.47e-06	3	25	2	CID006443812
Drug	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone	PTGS1 PTGS2	6.94e-06	4	25	2	ctd:C106876
Drug	Balsalazide	PTGS1 PTGS2	6.94e-06	4	25	2	DB01014
Drug	2-(6-carboxyhexyl)cyclopentanone hexylhydrazone	PTGS1 PTGS2	6.94e-06	4	25	2	CID000134996
Drug	anolignan B	PTGS1 PTGS2	6.94e-06	4	25	2	CID000072388
Drug	Flufenamic Acid	PTGS1 PTGS2	6.94e-06	4	25	2	DB02266
Drug	oleanolic aldehyde	PTGS1 PTGS2	6.94e-06	4	25	2	CID005320280
Drug	AI-122	PTGS1 PTGS2	6.94e-06	4	25	2	CID000134058
Drug	12-HPETE	PTGS1 PTGS2	6.94e-06	4	25	2	ctd:C021201
Drug	NSC-327431	PTGS1 PTGS2	6.94e-06	4	25	2	CID000362637
Drug	triacontanol	PTGS1 PTGS2	6.94e-06	4	25	2	CID000068972
Drug	prostaglandin G2	PTGS1 PTGS2	6.94e-06	4	25	2	ctd:C038291
Drug	2-chloropyridine	PTGS1 PTGS2	6.94e-06	4	25	2	CID000007977
Drug	prantschimgin	PTGS1 PTGS2	6.94e-06	4	25	2	CID000025785
Drug	Resveratrol	PTGS1 PTGS2	6.94e-06	4	25	2	DB02709
Drug	Niflumic Acid	PTGS1 PTGS2	6.94e-06	4	25	2	DB04552
Drug	C9H7BrO4	PTGS1 PTGS2	6.94e-06	4	25	2	CID000073922
Drug	sulfanilide	PTGS1 PTGS2	6.94e-06	4	25	2	CID000068517
Drug	8beta-prostane	PTGS1 PTGS2	6.94e-06	4	25	2	CID000107873
Drug	SC57666	PTGS1 PTGS2	6.94e-06	4	25	2	CID000443373
Drug	glyceryl 2-arachidonate	PTGS1 PTGS2 CNR2	7.48e-06	35	25	3	ctd:C094503
Drug	REV 5901	PTGS1 PTGS2 CNR2	1.04e-05	39	25	3	CID000005059
Drug	1-octanoyl-2-acetylglycerol	PTGS1 PTGS2	1.16e-05	5	25	2	CID000130710
Drug	sakuranin	PTGS1 PTGS2	1.16e-05	5	25	2	CID000073607
Drug	4'-piperidinoacetophenone	PTGS1 PTGS2	1.16e-05	5	25	2	CID000082561
Drug	nictindole	PTGS1 PTGS2	1.16e-05	5	25	2	CID000065796
Drug	Indomethacin	PTGS1 PTGS2	1.16e-05	5	25	2	DB00328
Drug	4-(nitroxy)butanoic acid 4-acetylaminophenyl ester	PTGS1 PTGS2	1.16e-05	5	25	2	ctd:C478738
Drug	fenflumizole	PTGS1 PTGS2	1.16e-05	5	25	2	CID000068917
Drug	Flupenthixol	PTGS1 PTGS2	1.16e-05	5	25	2	ctd:D005475
Drug	4-methylesculetin	PTGS1 PTGS2	1.16e-05	5	25	2	CID005319502
Drug	loxoprofen	PTGS1 PTGS2	1.16e-05	5	25	2	ctd:C040656
Drug	M 5011	PTGS1 PTGS2	1.16e-05	5	25	2	CID000127523
Drug	dithymoquinone	PTGS1 PTGS2	1.16e-05	5	25	2	CID000398941
Drug	DuP 697	PTGS1 PTGS2	1.16e-05	5	25	2	ctd:C064874
Drug	PGF-M	PTGS1 PTGS2	1.16e-05	5	25	2	CID003082337
Drug	Sulindac	PTGS1 PTGS2	1.16e-05	5	25	2	DB00605
Drug	12-HPETE	PTGS1 PTGS2 CNR2	1.40e-05	43	25	3	CID000001415
Drug	palmitoylethanolamide	PTGS1 PTGS2 CNR2	1.50e-05	44	25	3	CID000004671
Drug	15-hydroperoxy-PGE2	PTGS1 PTGS2	1.73e-05	6	25	2	CID006444110
Drug	desproglumideproglumetacin	PTGS1 PTGS2	1.73e-05	6	25	2	CID000126678
Drug	proglumetacin	PTGS1 PTGS2	1.73e-05	6	25	2	CID000004921
Drug	2,6-dimethoxyquinol	PTGS1 PTGS2	1.73e-05	6	25	2	CID000096038
Drug	KBT-3022	PTGS1 PTGS2	1.73e-05	6	25	2	CID000065870
Drug	isolicoflavonol	PTGS1 PTGS2	1.73e-05	6	25	2	CID005318585
Disease	Alzheimer's disease (implicated_via_orthology)	RCOR3 RCOR1 ANK2 PTGS1 PTGS2	7.36e-10	57	23	5	DOID:10652 (implicated_via_orthology)
Disease	gliosarcoma (biomarker_via_orthology)	PTGS1 PTGS2	5.81e-07	2	23	2	DOID:3071 (biomarker_via_orthology)
Disease	glioblastoma (biomarker_via_orthology)	PTGS1 PTGS2	3.48e-06	4	23	2	DOID:3068 (biomarker_via_orthology)
Disease	Intestinal Polyps	PTGS1 PTGS2	5.80e-06	5	23	2	C0021846
Disease	ulcerative colitis (implicated_via_orthology)	PTGS1 PTGS2	1.22e-05	7	23	2	DOID:8577 (implicated_via_orthology)
Disease	Creutzfeldt-Jakob disease (is_marker_for)	PTGS1 PTGS2	2.61e-05	10	23	2	DOID:11949 (is_marker_for)
Disease	Asthma, Occupational	PTGS1 PTGS2	2.61e-05	10	23	2	C0264423
Disease	Mechanical Allodynia	PTGS1 PTGS2 CNR2	3.78e-05	84	23	3	C2936719
Disease	Hyperalgesia	PTGS1 PTGS2 CNR2	3.78e-05	84	23	3	C0020429
Disease	Allodynia	PTGS1 PTGS2 CNR2	3.78e-05	84	23	3	C0458247
Disease	Hyperalgesia, Secondary	PTGS1 PTGS2 CNR2	3.78e-05	84	23	3	C0751212
Disease	Hyperalgesia, Primary	PTGS1 PTGS2 CNR2	3.78e-05	84	23	3	C0751211
Disease	Hyperalgesia, Thermal	PTGS1 PTGS2 CNR2	3.78e-05	84	23	3	C0751214
Disease	Tactile Allodynia	PTGS1 PTGS2 CNR2	3.78e-05	84	23	3	C0751213
Disease	renal cell carcinoma (biomarker_via_orthology)	PTGS1 PTGS2	5.26e-05	14	23	2	DOID:4450 (biomarker_via_orthology)
Disease	Gastric ulcer	PTGS1 PTGS2	8.82e-05	18	23	2	C0038358
Disease	bipolar disorder (is_marker_for)	PTGS1 PTGS2	9.86e-05	19	23	2	DOID:3312 (is_marker_for)
Disease	Marijuana Abuse	PTGS2 CNR2	2.49e-04	30	23	2	C0024809
Disease	Huntington's disease (implicated_via_orthology)	PTGS2 CNR2	2.84e-04	32	23	2	DOID:12858 (implicated_via_orthology)
Disease	Kidney Neoplasm	FLCN PTGS2	4.45e-04	40	23	2	C0022665
Disease	Depression, Neurotic	PTGS2 CNR2	4.68e-04	41	23	2	C0282126
Disease	Melancholia	PTGS2 CNR2	4.68e-04	41	23	2	C0025193
Disease	Depressive Syndrome	PTGS2 CNR2	4.91e-04	42	23	2	C0086133
Disease	Schizophrenia	CSMD2 PTGS1 PTGS2 CNR2 CFAP65	5.10e-04	883	23	5	C0036341
Disease	glioblastoma (is_marker_for)	PTGS1 PTGS2	5.39e-04	44	23	2	DOID:3068 (is_marker_for)
Disease	Malignant neoplasm of kidney	FLCN PTGS2	5.64e-04	45	23	2	C0740457
Disease	Endogenous depression	PTGS2 CNR2	5.89e-04	46	23	2	C0011573
Disease	Kidney Failure, Chronic	PTGS1 PTGS2	6.41e-04	48	23	2	C0022661
Disease	response to TNF antagonist	NLRP10 CSMD2	8.11e-04	54	23	2	EFO_0004653
Disease	Acute Cerebrovascular Accidents	ANK2 PTGS2	8.11e-04	54	23	2	C0751956
Disease	Atherogenesis	PTGS2 CNR2	9.68e-04	59	23	2	C1563937
Disease	Pancreatitis	PTGS2 CNR2	9.68e-04	59	23	2	C0030305
Disease	Atherosclerosis	PTGS2 CNR2	9.68e-04	59	23	2	C0004153
Disease	Mental Depression	CSMD2 PTGS2 CNR2	9.83e-04	254	23	3	C0011570
Disease	Cerebrovascular accident	ANK2 PTGS2	1.07e-03	62	23	2	C0038454
Disease	Depressive disorder	CSMD2 PTGS2 CNR2	1.42e-03	289	23	3	C0011581

Protein segments in the cluster

Peptide	Gene	Start	Entry
SFFNVSDGSHIFTFH	BTNL9	461	Q6UXG8
TSHGKGVFFTFHTFH	CSMD2	956	Q7Z408
VFAFTNFSSSHDHFR	CSPG4	2011	Q6UVK1
VFACSFVNFHVFHGV	CNR2	86	P34972
VLFEQAFSFHGKTFH	RCOR1	201	Q9UKL0
LFEQAFSFHGKSFHR	RCOR3	96	Q9P2K3
GQHHIFSFFAFKENR	ANK2	1396	Q01484
PAFFSFFSHRFGEHI	OR52N4	256	Q8NGI2
VSFDHAPHNFGFRFF	IL17RD	216	Q8NFM7
IFFGDEQHGFVFSHT	FLCN	141	Q8NFG4
FYSFRHISFQDFFHA	NLRP10	461	Q86W26
FLANFFSEFPCHFLH	CFAP65	1626	Q6ZU64
LLAFFSFFTHRFGSH	OR52A1	256	Q9UKL2
LLAFFSFFTHRFGSH	OR52A5	256	Q9H2C5
FFAQHFTHQFFKTDH	PTGS2	186	P35354
AAFFTFFTHRFVGHN	OR52N2	256	Q8NGI0
MFAFFAQHFTHQFFK	PTGS1	196	P23219
FFTPAFFSFLTHRFG	OR52E8	256	Q6IFG1
FVIHSGFFFDNNSHD	SETD3	321	Q86TU7
IGVHFVFDTAFSRHF	CIAO3	146	Q9H6Q4
IFNAFATAAFRFGHT	PXDN	1061	Q92626
HAFHTCGVFSTLAFF	TMEM50B	56	P56557
FFQHRIHWFSIFNSF	TM9SF3	216	Q9HD45
QFHFAFLFLTHFNTH	TMEM187	236	Q14656
AIPSDVSHFRFHFFF	TMEM39B	401	Q9GZU3