Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulatory subunit binding	NLRC3 DNM2	1.59e-04	14	27	2	GO:0036312
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE4B PDE4D	4.00e-04	22	27	2	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE4B PDE4D	4.77e-04	24	27	2	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE4B PDE4D	5.18e-04	25	27	2	GO:0004114
GeneOntologyMolecularFunction	cAMP binding	PDE4B PDE4D	5.18e-04	25	27	2	GO:0030552
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE4B PDE4D	6.05e-04	27	27	2	GO:0004112
GeneOntologyMolecularFunction	cyclic nucleotide binding	PDE4B PDE4D	1.27e-03	39	27	2	GO:0030551
GeneOntologyMolecularFunction	ion channel regulator activity	PDE4B PDE4D KCNIP3	1.33e-03	162	27	3	GO:0099106
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase binding	NLRC3 DNM2	1.54e-03	43	27	2	GO:0043548
GeneOntologyMolecularFunction	transmembrane transporter binding	PDE4B PDE4D KCNIP3	1.58e-03	172	27	3	GO:0044325
GeneOntologyMolecularFunction	channel regulator activity	PDE4B PDE4D KCNIP3	1.63e-03	174	27	3	GO:0016247
GeneOntologyMolecularFunction	transporter regulator activity	PDE4B PDE4D KCNIP3	1.71e-03	177	27	3	GO:0141108
GeneOntologyMolecularFunction	calcium channel regulator activity	PDE4B PDE4D	2.41e-03	54	27	2	GO:0005246
GeneOntologyMolecularFunction	calcium ion binding	MACF1 MYL10 KCNIP3 CALU RYR1	2.98e-03	749	27	5	GO:0005509
GeneOntologyBiologicalProcess	negative regulation of relaxation of cardiac muscle	PDE4B PDE4D	1.65e-06	2	27	2	GO:1901898
GeneOntologyBiologicalProcess	negative regulation of relaxation of muscle	PDE4B PDE4D	3.45e-05	7	27	2	GO:1901078
GeneOntologyBiologicalProcess	cAMP catabolic process	PDE4B PDE4D	5.91e-05	9	27	2	GO:0006198
GeneOntologyBiologicalProcess	regulation of relaxation of cardiac muscle	PDE4B PDE4D	5.91e-05	9	27	2	GO:1901897
GeneOntologyBiologicalProcess	regulation of G protein-coupled receptor signaling pathway	PDE4B PDE4D ECE1 DNM2	8.60e-05	181	27	4	GO:0008277
GeneOntologyBiologicalProcess	cAMP-mediated signaling	PDE4B PDE4D ECE1	1.32e-04	76	27	3	GO:0019933
GeneOntologyBiologicalProcess	cyclic nucleotide catabolic process	PDE4B PDE4D	1.49e-04	14	27	2	GO:0009214
GeneOntologyBiologicalProcess	cellular response to epinephrine stimulus	PDE4B PDE4D	1.49e-04	14	27	2	GO:0071872
GeneOntologyBiologicalProcess	negative regulation of G protein-coupled receptor signaling pathway	PDE4B PDE4D DNM2	1.59e-04	81	27	3	GO:0045744
GeneOntologyBiologicalProcess	response to epinephrine	PDE4B PDE4D	2.22e-04	17	27	2	GO:0071871
GeneOntologyBiologicalProcess	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	PDE4B PDE4D	2.49e-04	18	27	2	GO:0106072
GeneOntologyBiologicalProcess	regulation of relaxation of muscle	PDE4B PDE4D	2.78e-04	19	27	2	GO:1901077
GeneOntologyBiologicalProcess	relaxation of cardiac muscle	PDE4B PDE4D	3.41e-04	21	27	2	GO:0055119
GeneOntologyBiologicalProcess	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	PDE4B PDE4D	3.75e-04	22	27	2	GO:1902514
GeneOntologyBiologicalProcess	calcium ion transmembrane transport via high voltage-gated calcium channel	PDE4B PDE4D	4.10e-04	23	27	2	GO:0061577
GeneOntologyBiologicalProcess	cAMP metabolic process	PDE4B PDE4D	4.86e-04	25	27	2	GO:0046058
GeneOntologyBiologicalProcess	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	PDE4B PDE4D	5.26e-04	26	27	2	GO:0106070
GeneOntologyBiologicalProcess	regulation of muscle system process	PDE4B PDE4D ECE1 RYR1	7.27e-04	317	27	4	GO:0090257
GeneOntologyBiologicalProcess	adrenergic receptor signaling pathway	PDE4B PDE4D	9.56e-04	35	27	2	GO:0071875
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PDE4D RYR1	1.07e-03	37	27	2	GO:0014808
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by endoplasmic reticulum	PDE4D RYR1	1.19e-03	39	27	2	GO:1903514
GeneOntologyBiologicalProcess	regulation of cAMP-mediated signaling	PDE4D ECE1	1.25e-03	40	27	2	GO:0043949
GeneOntologyBiologicalProcess	positive regulation of interleukin-2 production	PDE4B PDE4D	1.38e-03	42	27	2	GO:0032743
GeneOntologyBiologicalProcess	relaxation of muscle	PDE4B PDE4D	1.38e-03	42	27	2	GO:0090075
GeneOntologyBiologicalProcess	vesicle-mediated transport to the plasma membrane	MACF1 SNX7 DNM2	1.44e-03	172	27	3	GO:0098876
GeneOntologyBiologicalProcess	regulation of cardiac muscle cell contraction	PDE4B PDE4D	1.44e-03	43	27	2	GO:0086004
GeneOntologyBiologicalProcess	sarcoplasmic reticulum calcium ion transport	PDE4D RYR1	1.51e-03	44	27	2	GO:0070296
GeneOntologyBiologicalProcess	cyclic purine nucleotide metabolic process	PDE4B PDE4D	1.51e-03	44	27	2	GO:0052652
GeneOntologyBiologicalProcess	metal ion transport	PDE4B PDE4D KCNA3 KCNIP3 RYR1 DNM2	1.58e-03	1000	27	6	GO:0030001
GeneOntologyBiologicalProcess	cyclic nucleotide metabolic process	PDE4B PDE4D	1.58e-03	45	27	2	GO:0009187
GeneOntologyCellularComponent	cation channel complex	PDE4B PDE4D KCNA3 KCNIP3 RYR1	1.14e-05	235	27	5	GO:0034703
GeneOntologyCellularComponent	perinuclear region of cytoplasm	PDE4B PDE4D ECE1 NLRC3 GOLGA1 RYR1 DNM2 ADGRB1	1.60e-05	934	27	8	GO:0048471
GeneOntologyCellularComponent	voltage-gated calcium channel complex	PDE4B PDE4D RYR1	2.81e-05	46	27	3	GO:0005891
GeneOntologyCellularComponent	monoatomic ion channel complex	PDE4B PDE4D KCNA3 KCNIP3 RYR1	1.10e-04	378	27	5	GO:0034702
GeneOntologyCellularComponent	calcium channel complex	PDE4B PDE4D RYR1	1.13e-04	73	27	3	GO:0034704
GeneOntologyCellularComponent	potassium channel complex	PDE4D KCNA3 KCNIP3	3.21e-04	104	27	3	GO:0034705
GeneOntologyCellularComponent	transmembrane transporter complex	PDE4B PDE4D KCNA3 KCNIP3 RYR1	4.92e-04	523	27	5	GO:1902495
GeneOntologyCellularComponent	transporter complex	PDE4B PDE4D KCNA3 KCNIP3 RYR1	6.19e-04	550	27	5	GO:1990351
GeneOntologyCellularComponent	phagocytic cup	DNM2 ADGRB1	7.30e-04	31	27	2	GO:0001891
GeneOntologyCellularComponent	Golgi apparatus subcompartment	ASAP2 DNMBP GOLGA1 DNM2	2.37e-03	443	27	4	GO:0098791
GeneOntologyCellularComponent	postsynaptic density	MACF1 PDE4B DNM2 ADGRB1	2.53e-03	451	27	4	GO:0014069
GeneOntologyCellularComponent	plasma membrane protein complex	PDE4B PDE4D KCNA3 KCNIP3 RYR1	2.99e-03	785	27	5	GO:0098797
GeneOntologyCellularComponent	asymmetric synapse	MACF1 PDE4B DNM2 ADGRB1	3.10e-03	477	27	4	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	MACF1 PDE4B DNM2 ADGRB1	3.75e-03	503	27	4	GO:0099572
GeneOntologyCellularComponent	neuron to neuron synapse	MACF1 PDE4B DNM2 ADGRB1	4.30e-03	523	27	4	GO:0098984
GeneOntologyCellularComponent	presynapse	PDE4B KCNA3 KCNIP3 DNMBP DNM2	5.02e-03	886	27	5	GO:0098793
GeneOntologyCellularComponent	myofibril	PDE4B PDE4D RYR1	5.11e-03	273	27	3	GO:0030016
GeneOntologyCellularComponent	phagocytic vesicle membrane	RAB11FIP1 DNM2	5.13e-03	83	27	2	GO:0030670
GeneOntologyCellularComponent	sarcoplasmic reticulum	CALU RYR1	5.74e-03	88	27	2	GO:0016529
GeneOntologyCellularComponent	contractile muscle fiber	PDE4B PDE4D RYR1	6.04e-03	290	27	3	GO:0043292
GeneOntologyCellularComponent	voltage-gated potassium channel complex	KCNA3 KCNIP3	6.13e-03	91	27	2	GO:0008076
GeneOntologyCellularComponent	ruffle membrane	MACF1 DNM2	8.53e-03	108	27	2	GO:0032587
GeneOntologyCellularComponent	postsynapse	MACF1 PDE4B KCNA3 DNM2 ADGRB1	8.95e-03	1018	27	5	GO:0098794
GeneOntologyCellularComponent	sarcoplasm	CALU RYR1	9.47e-03	114	27	2	GO:0016528
Domain	EF-hand_8	KCNIP3 CALU RYR1	1.56e-05	34	27	3	PF13833
Domain	EF_hand_dom	MACF1 MYL10 KCNIP3 CALU RYR1	1.83e-05	232	27	5	IPR002048
Domain	-	MACF1 MYL10 KCNIP3 CALU RYR1	3.22e-05	261	27	5	1.10.238.10
Domain	EF-hand-dom_pair	MACF1 MYL10 KCNIP3 CALU RYR1	5.06e-05	287	27	5	IPR011992
Domain	EFh	MACF1 MYL10 KCNIP3 CALU	7.43e-05	158	27	4	SM00054
Domain	EF_Hand_1_Ca_BS	MACF1 MYL10 KCNIP3 CALU	1.10e-04	175	27	4	IPR018247
Domain	EF_HAND_1	MACF1 MYL10 KCNIP3 CALU	1.99e-04	204	27	4	PS00018
Domain	EF_HAND_2	MACF1 MYL10 KCNIP3 CALU	3.20e-04	231	27	4	PS50222
Domain	PDEase	PDE4B PDE4D	3.39e-04	19	27	2	IPR023088
Domain	PDEase_I	PDE4B PDE4D	4.16e-04	21	27	2	PF00233
Domain	PDEASE_I	PDE4B PDE4D	4.16e-04	21	27	2	PS00126
Domain	PDEase_CS	PDE4B PDE4D	4.16e-04	21	27	2	IPR023174
Domain	-	PDE4B PDE4D	4.57e-04	22	27	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE4B PDE4D	5.00e-04	23	27	2	IPR002073
Domain	HDc	PDE4B PDE4D	5.45e-04	24	27	2	SM00471
Domain	HD/PDEase_dom	PDE4B PDE4D	5.45e-04	24	27	2	IPR003607
Domain	-	ASAP2 DNMBP	8.54e-04	30	27	2	1.20.1270.60
Domain	AH/BAR-dom	ASAP2 DNMBP	8.54e-04	30	27	2	IPR027267
Domain	EF-hand_1	MACF1 KCNIP3 CALU	1.34e-03	152	27	3	PF00036
Domain	SH3	MACF1 ASAP2 DNMBP	3.64e-03	216	27	3	PS50002
Domain	SH3_domain	MACF1 ASAP2 DNMBP	3.83e-03	220	27	3	IPR001452
Domain	SH3_9	ASAP2 DNMBP	5.65e-03	78	27	2	PF14604
Domain	EF-hand_7	MACF1 KCNIP3	6.67e-03	85	27	2	PF13499
Domain	Ion_trans_dom	KCNA3 RYR1	1.17e-02	114	27	2	IPR005821
Pathway	REACTOME_DARPP_32_EVENTS	PDE4B PDE4D	2.04e-04	16	19	2	MM14699
Pathway	WP_SILDENAFIL_TREATMENT	PDE4B PDE4D	4.28e-04	23	19	2	M46455
Pathway	REACTOME_DARPP_32_EVENTS	PDE4B PDE4D	4.67e-04	24	19	2	M751
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	PDE4B PDE4D RYR1	1.09e-03	154	19	3	MM15974
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	PDE4B PDE4D RYR1	1.13e-03	156	19	3	M39475
Pathway	REACTOME_MUSCLE_CONTRACTION	MYL10 KCNIP3 RYR1	1.33e-03	165	19	3	MM15026
Pathway	KEGG_ENDOCYTOSIS	ASAP2 RAB11FIP1 DNM2	1.73e-03	181	19	3	M1519
Pathway	PID_ARF6_TRAFFICKING_PATHWAY	ASAP2 DNM2	1.95e-03	49	19	2	M67
Pathway	REACTOME_MUSCLE_CONTRACTION	MYL10 KCNIP3 RYR1	2.40e-03	203	19	3	M5485
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	PDE4B PDE4D	2.45e-03	55	19	2	M39763
Pubmed	Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.	PDE4B PDE4D KCNA3	2.32e-07	16	27	3	28283561
Pubmed	PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.	PDE4B PDE4D	5.80e-07	2	27	2	21288894
Pubmed	Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study.	PDE4B PDE4D	5.80e-07	2	27	2	31324945
Pubmed	PDE4D plays a critical role in the control of airway smooth muscle contraction.	PDE4B PDE4D	5.80e-07	2	27	2	14519662
Pubmed	Overexpression of phosphodiesterase-4 subtypes involved in surgery-induced neuroinflammation and cognitive dysfunction in mice.	PDE4B PDE4D	5.80e-07	2	27	2	28235598
Pubmed	Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).	PDE4B PDE4D	5.80e-07	2	27	2	17700644
Pubmed	Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.	PDE4B PDE4D	5.80e-07	2	27	2	29123207
Pubmed	PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.	PDE4B PDE4D	5.80e-07	2	27	2	17088426
Pubmed	Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.	PDE4B PDE4D	5.80e-07	2	27	2	15003452
Pubmed	FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network.	RAB11FIP1 GOLGA1	5.80e-07	2	27	2	20610657
Pubmed	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.	MACF1 ASAP2 RAB11FIP1	1.21e-06	27	27	3	18685082
Pubmed	Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.	PDE4B PDE4D	1.74e-06	3	27	2	10213096
Pubmed	Regulation of Bin1 SH3 domain binding by phosphoinositides.	ASAP2 DNM2	1.74e-06	3	27	2	15483625
Pubmed	The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).	PDE4B PDE4D	1.74e-06	3	27	2	24555506
Pubmed	Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.	PDE4B PDE4D	1.74e-06	3	27	2	16034090
Pubmed	Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.	PDE4B PDE4D	1.74e-06	3	27	2	15585880
Pubmed	Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.	PDE4B PDE4D	1.74e-06	3	27	2	18508768
Pubmed	Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.	PDE4B PDE4D	1.74e-06	3	27	2	17404263
Pubmed	Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.	PDE4B PDE4D	3.48e-06	4	27	2	11839681
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4B PDE4D	3.48e-06	4	27	2	24732776
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4B PDE4D	3.48e-06	4	27	2	32738081
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4B PDE4D	3.48e-06	4	27	2	22946044
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4B PDE4D	3.48e-06	4	27	2	8413254
Pubmed	Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.	PDE4B PDE4D	3.48e-06	4	27	2	15644445
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4B PDE4D	3.48e-06	4	27	2	34943270
Pubmed	Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity.	PDE4D RYR1	3.48e-06	4	27	2	18268335
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4B PDE4D	3.48e-06	4	27	2	33609559
Pubmed	Centronuclear myopathies: genotype-phenotype correlation and frequency of defined genetic forms in an Italian cohort.	RYR1 DNM2	3.48e-06	4	27	2	25957634
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4B PDE4D	3.48e-06	4	27	2	9371714
Pubmed	Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.	PDE4B PDE4D	3.48e-06	4	27	2	21670503
Pubmed	Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.	PDE4B PDE4D	5.80e-06	5	27	2	21652625
Pubmed	Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.	PDE4B PDE4D	5.80e-06	5	27	2	28383060
Pubmed	A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.	PDE4B PDE4D	5.80e-06	5	27	2	8586960
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4B PDE4D	5.80e-06	5	27	2	33944911
Pubmed	Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.	PDE4B PDE4D	8.69e-06	6	27	2	18923023
Pubmed	Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation.	RYR1 DNM2	1.22e-05	7	27	2	29130937
Pubmed	DISC1, PDE4B, and NDE1 at the centrosome and synapse.	PDE4B PDE4D	1.22e-05	7	27	2	18983980
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	ASAP2 KCNA3 RARS1 RYR1	1.96e-05	208	27	4	33230847
Pubmed	Protein partners of dynamin-1 in the retina.	MYL10 DNM2	2.60e-05	10	27	2	23746204
Pubmed	Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.	PDE4B PDE4D	3.81e-05	12	27	2	19251251
Pubmed	Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.	PDE4B PDE4D	4.50e-05	13	27	2	8009369
Pubmed	Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.	PDE4B PDE4D	5.25e-05	14	27	2	25852085
Pubmed	Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.	RYR1 DNM2	6.92e-05	16	27	2	32994313
Pubmed	Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.	PDE4B KCNA3	6.92e-05	16	27	2	22076464
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	ASAP2 SNX7 RYR1 DNM2	1.16e-04	329	27	4	17474147
Pubmed	Overview of PDEs and their regulation.	PDE4B PDE4D	1.72e-04	25	27	2	17307970
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	MACF1 RARS1 RAB11FIP1 ECE1 CALU DNM2	4.01e-04	1297	27	6	33545068
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	MACF1 KCNA3 ADGRB1	4.74e-04	197	27	3	36604605
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	MARF1 ASAP2	7.51e-04	52	27	2	9455477
GeneFamily	EF-hand domain containing	MACF1 MYL10 KCNIP3 CALU	7.04e-05	219	19	4	863
GeneFamily	Phosphodiesterases	PDE4B PDE4D	2.85e-04	24	19	2	681
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	MARF1 RYR1	1.52e-02	181	19	2	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ASAP2 DNM2	1.94e-02	206	19	2	682
Coexpression	GSE16450_CTRL_VS_IFNA_6H_STIM_IMMATURE_NEURON_CELL_LINE_DN	MARF1 PDE4D C1orf21 NLRC3	3.91e-05	195	26	4	M7410
Coexpression	GSE5455_HEALTHY_VS_TUMOR_BEARING_MOUSE_SPLEEN_MONOCYTE_UP	NDNF ASAP2 KCNA3 RYR1	4.06e-05	197	26	4	M6575
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1orf21 RAB11FIP1 ECE1 RYR1	3.38e-06	172	27	4	a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell	COPD-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	PDE4B PDE4D ECE1 DNMBP	4.91e-06	189	27	4	6294691231c7d38707323cf31578a107d3b2c622
ToppCell	Epithelial-Epithelial-A_(AT1)\|Epithelial / shred on cell class and cell subclass (v4)	NDNF MACF1 RAB11FIP1 ECE1	5.67e-06	196	27	4	41b21a18125cc95bc8adde3369e4abd029cf137d
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	MACF1 ASAP2 PDE4B ECE1	6.14e-06	200	27	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	MACF1 ASAP2 PDE4B ECE1	6.14e-06	200	27	4	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	MACF1 ASAP2 PDE4B ECE1	6.14e-06	200	27	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Tumor_ECs\|Endothelial_cells / Location, Cell class and cell subclass	PDE4D C1orf21 RARS1	5.56e-05	123	27	3	de29861800d083e4977afbef59c1a81336824703
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	ASAP2 DNMBP DNM2	1.19e-04	159	27	3	655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNA3 C1orf21 RYR1	1.24e-04	161	27	3	76c993a4533362db2250c88b3ee3ede55362d54e
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNA3 C1orf21 RYR1	1.30e-04	164	27	3	5638d95c7cc5e59c4a7bda30268a904a01861a5f
ToppCell	droplet-Lung-nan-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1orf21 DNMBP RYR1	1.38e-04	167	27	3	f33cef917fa733adf6d5a9a9e989a4d9fd462a8f
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1orf21 KCNIP3 RYR1	1.40e-04	168	27	3	d6078e3a79d315d6090906e171a7d67a9206b2c7
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_11\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	C1orf21 ECE1 ADGRB1	1.43e-04	169	27	3	e3410ccb3f85811c75694e286115803911169a2f
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1orf21 ECE1 KCNIP3	1.43e-04	169	27	3	b2d53159e344fad6fcdc485d5b8f6cf1bf094b1f
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_11\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	C1orf21 ECE1 ADGRB1	1.43e-04	169	27	3	a4f610d07c3ba5537f4497f523669b914f7eddc1
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1orf21 KCNIP3 RYR1	1.43e-04	169	27	3	9c9bb1b32fc6e22359424a262178906c3954415d
ToppCell	facs\|World / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MARF1 PDE4B ECE1	1.48e-04	171	27	3	5bcb96ed7fc15548f2dc9cf47482f890640cb39c
ToppCell	facs\|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MARF1 PDE4B KCNA3	1.48e-04	171	27	3	c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCell	facs\|World / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MARF1 PDE4B ECE1	1.48e-04	171	27	3	bb71e816dde44fda6af0ad98d979be9f8740fda6
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1orf21 KCNIP3 RYR1	1.48e-04	171	27	3	a3e3fe0cbab21abb178c482f5951e576529f7e30
ToppCell	normal-na-Lymphocytic_T-T4_em-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	MACF1 PDE4D KCNA3	1.48e-04	171	27	3	61318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1orf21 KCNIP3 RYR1	1.48e-04	171	27	3	0385d5834ae16bbb0c6a68893fec60e4dd1e478d
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1orf21 ECE1 RYR1	1.50e-04	172	27	3	7fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1orf21 ECE1 RYR1	1.50e-04	172	27	3	2a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCell	droplet-Lung-nan-21m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1orf21 ECE1 RYR1	1.55e-04	174	27	3	2afa5eea54b67c549c5058ece98296eee3829c11
ToppCell	ICU-SEP-Myeloid-cDC2\|ICU-SEP / Disease, Lineage and Cell Type	RSPH3 ASAP2 GOLGA1	1.58e-04	175	27	3	c44fd1cc827296de7300d4a60399bb945089a170
ToppCell	P03-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NDNF MACF1 RAB11FIP1	1.61e-04	176	27	3	f3a54038cde58326f1caed96ecca33c141bcc8b3
ToppCell	droplet-Marrow-nan-3m-Hematologic-hematopoietic_precursor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MACF1 C1orf21 MYL10	1.66e-04	178	27	3	8aef208b6351143562c87715bb11628880abce94
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Trm_Th1/Th17\|GI_large-bowel / Manually curated celltypes from each tissue	PDE4D KCNA3 RAB11FIP1	1.69e-04	179	27	3	6359f30005b17dc5b5c4c8f3a6a38c87ccfe4ee9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NDNF C1orf21 ZBTB7C	1.80e-04	183	27	3	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NDNF C1orf21 ZBTB7C	1.80e-04	183	27	3	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NDNF C1orf21 ZBTB7C	1.83e-04	184	27	3	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	PDE4B ECE1 DNMBP	1.83e-04	184	27	3	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	10x5'v1-week_12-13-Lymphocytic_NK-T_NK-mature_NK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PDE4D C1orf21 NLRC3	1.89e-04	186	27	3	165d02be3b3eaeb8784a2b0b2020928b21a19bc7
ToppCell	AT1_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	NDNF RAB11FIP1 ECE1	1.92e-04	187	27	3	f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASAP2 PDE4B ECE1	1.92e-04	187	27	3	52ffd4be374e329ac8d321063f061b826d252956
ToppCell	Control-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	PDE4D ECE1 DNMBP	1.95e-04	188	27	3	47126c371a242c937499fd278a74a882df8f759c
ToppCell	P03-Endothelial\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ASAP2 PDE4B ECE1	1.95e-04	188	27	3	88d477aad98be124919b9c6b0b8dbd24e556422e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MACF1 C1orf21 NLRC3	1.95e-04	188	27	3	5ae8ccdd328cf117da1d01ced2c3b7f763a5f1f1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_ILC\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MACF1 C1orf21 NLRC3	1.95e-04	188	27	3	9abd78970bbe4ed03b59a83da63bbd334712f605
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	NDNF PDE4D RAB11FIP1	1.95e-04	188	27	3	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	IPF-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	PDE4D ECE1 DNMBP	1.98e-04	189	27	3	ad7bb3a7de8e48c145e4382f90d30bb2159c2b76
ToppCell	Severe-Myeloid-Macrophages-\|Severe / Condition, Lineage, Cell class and cell subclass	PDE4B PDE4D NLRC3	1.98e-04	189	27	3	769b52073a0f0543a72e9f32772321194b70cb2f
ToppCell	Non-neuronal-Non-dividing-OPC\|World / Primary Cells by Cluster	PDE4B C1orf21 KCNIP3	1.98e-04	189	27	3	13848a031ab896b4b24c8319e4745b9b17ff9cfd
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ASAP2 PDE4B ECE1	1.98e-04	189	27	3	360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell	Non-neuronal-Non-dividing-OPC-OPC\|World / Primary Cells by Cluster	PDE4B C1orf21 KCNIP3	1.98e-04	189	27	3	ddf5be73912570c32c50f4ac2902da9b590526f8
ToppCell	Non-neuronal-Non-dividing-OPC-OPC-30\|World / Primary Cells by Cluster	PDE4B C1orf21 KCNIP3	1.98e-04	189	27	3	313d165fad541ec6e8dd524b88856e2c93eeb681
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4B PDE4D KCNA3	2.01e-04	190	27	3	494fbab37305a7f92cddec75b291d42282555f5f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	C1orf21 ZBTB7C ECE1	2.01e-04	190	27	3	656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	PDE4D ECE1 DNMBP	2.01e-04	190	27	3	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4B PDE4D KCNA3	2.01e-04	190	27	3	55df73c8b696967a925b1772631f6900eff0fa30
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE4B C1orf21 ECE1	2.01e-04	190	27	3	3639eb9b887a2d76949cad4a2586524fe0e1015f
ToppCell	facs-Marrow-KLS-18m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1orf21 ECE1 KCNIP3	2.01e-04	190	27	3	c03c735a0ed850bf460a1847f5e2dd61753e577d
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDE4B DNMBP RYR1	2.01e-04	190	27	3	2d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCell	P07\|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PDE4B PDE4D CALU	2.01e-04	190	27	3	38a613a9bca0ba040c3ada00286d1ce6f83ab23a
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4B PDE4D NLRC3	2.01e-04	190	27	3	423b54c6d48d6981a9522043252239303dccaf04
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4B PDE4D NLRC3	2.01e-04	190	27	3	81e7d4f97b958b4ed14298a77104ef31a6ec6c91
ToppCell	3'_v3-blood-Lymphocytic_T_CD8-Tem/emra_CD8\|blood / Manually curated celltypes from each tissue	MACF1 C1orf21 NLRC3	2.01e-04	190	27	3	5624f711b34132081f93fa70702316962e3e3c64
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4B PDE4D NLRC3	2.01e-04	190	27	3	a1b19028c36d192352bc8a7f187790f4b56cfe17
ToppCell	LAM-Epithelial-AT1\|Epithelial / Condition, Lineage and Cell class	NDNF RAB11FIP1 ECE1	2.04e-04	191	27	3	3457e15d1e9b36a78363d46b320c4ec46b40290a
ToppCell	Endothelial-C\|World / shred on cell class and cell subclass (v4)	ASAP2 PDE4B ECE1	2.04e-04	191	27	3	bf203931f973098b79ec681d1dd0854419819e98
ToppCell	facs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ASAP2 PDE4B ECE1	2.08e-04	192	27	3	dfa6adc776621f4b51d731b796c0421855b2297c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASAP2 PDE4D RAB11FIP1	2.08e-04	192	27	3	2510f22197502f60fd266b7f42eff040f25b8ae7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASAP2 PDE4D RAB11FIP1	2.08e-04	192	27	3	e8e316f396834bcd34843e56e1d86f310fd6aada
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NDNF RAB11FIP1 DNM2	2.08e-04	192	27	3	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	facs-Thymus-nan-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE4D KCNA3 DNM2	2.14e-04	194	27	3	f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACF1 ASAP2 ECE1	2.14e-04	194	27	3	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASAP2 PDE4D RAB11FIP1	2.14e-04	194	27	3	46070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCell	10x5'v1-week_12-13-Lymphocytic_NK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PDE4D C1orf21 NLRC3	2.14e-04	194	27	3	5afe7f48d3383f3dac18765f97999c8b6936dc1b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MACF1 C1orf21 NLRC3	2.14e-04	194	27	3	24837a27b0041fe8c348225fa8b09b127d743603
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASAP2 PDE4D RAB11FIP1	2.14e-04	194	27	3	abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell	facs-Thymus-nan-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE4D KCNA3 DNM2	2.14e-04	194	27	3	66c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASAP2 PDE4B ECE1	2.14e-04	194	27	3	e30a3765feae5cd10ddba16a166c31eb5717edd3
ToppCell	10x5'v1-week_12-13-Lymphocytic_NK-T_NK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PDE4D C1orf21 NLRC3	2.14e-04	194	27	3	ec7e0ca6c9a2f63938e06ee771da09eff14fc3b5
ToppCell	facs-Thymus-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE4D KCNA3 DNM2	2.14e-04	194	27	3	cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-T-T_CD8-CD8_TRM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDE4B KCNA3 NLRC3	2.20e-04	196	27	3	a65d6a2d9eb3fca8faf323dbc4430e53134b7221
ToppCell	BAL-Severe-Lymphocyte-T/NK-NK_cell\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PDE4D C1orf21 NLRC3	2.20e-04	196	27	3	64b23d819efddb25024c86f2e1b5dc4159337ddd
ToppCell	BAL-Severe-Lymphocyte-T/NK-NK_cell-NK\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PDE4D C1orf21 NLRC3	2.20e-04	196	27	3	ba46f80d1497eaf4d71b59504106ba4b84e4ff9f
ToppCell	BAL-Severe-Lymphocyte-T/NK-NK_cell-NK-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PDE4D C1orf21 NLRC3	2.20e-04	196	27	3	eb0b711ca6da7b5e5313791c3c3985358e2a222e
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDNF RAB11FIP1 ECE1	2.20e-04	196	27	3	9790340c25f446ec655f5a0b64ec3bb44ed2e1bd
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDNF RAB11FIP1 ECE1	2.20e-04	196	27	3	b9ceceeacbcf81976ce92adf044f0d0aa132632b
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	MACF1 PDE4D C1orf21	2.20e-04	196	27	3	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	metastatic_Brain-Myeloid_cells-Monocytes\|Myeloid_cells / Location, Cell class and cell subclass	PDE4B PDE4D ECE1	2.20e-04	196	27	3	d1a2768a1d0e5928fbd9debb7dcd7436134e09f6
ToppCell	severe_influenza-CD8+_Tem\|World / disease group, cell group and cell class (v2)	MACF1 C1orf21 NLRC3	2.20e-04	196	27	3	40fb254abcab2e65affc5d6037e71893a031d264
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	MACF1 PDE4D C1orf21	2.20e-04	196	27	3	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MACF1 PDE4D C1orf21	2.20e-04	196	27	3	c100967851f037b3522130a9e2a4175ad593ecbc
ToppCell	BAL-Severe-Lymphocyte-T/NK-NK_cell-NK\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4D C1orf21 NLRC3	2.24e-04	197	27	3	48311c7d85ffabf59fd1685c31c18b3e84a145b5
ToppCell	Severe_COVID-19-T/NK-NK\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	PDE4D C1orf21 NLRC3	2.24e-04	197	27	3	cc20162892b59e48653981f91fc9a0c27064444d
ToppCell	Severe-Lymphoid-T-CCR7+_T\|Severe / Condition, Lineage, Cell class and cell subclass	PDE4B PDE4D KCNA3	2.24e-04	197	27	3	0489e0b08f3c3ef90b166ea2f26a0b2b12bd2077
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4B KCNA3 ECE1	2.24e-04	197	27	3	0b4fdf0131dd67a86ee3209fa66db0ca2e01a10e
ToppCell	Severe-Lymphoid-NK-NK\|Severe / Condition, Lineage, Cell class and cell subclass	PDE4D C1orf21 NLRC3	2.24e-04	197	27	3	d5b94f9f73e9d050245841b19b046242a32c6258
ToppCell	BAL-Severe-Lymphocyte-T/NK-NK_cell-NK-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4D C1orf21 NLRC3	2.24e-04	197	27	3	a26dd66a6bd08b46657b3a7c41669e206a8887b3
ToppCell	Mild-Lymphoid-T-CCR7+_T\|Mild / Condition, Lineage, Cell class and cell subclass	PDE4D KCNA3 ECE1	2.24e-04	197	27	3	f23bd8f6ad011730699a5bb7211cd0feeaebc42b
ToppCell	BAL-Severe-Lymphocyte-T/NK-NK_cell\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4D C1orf21 NLRC3	2.24e-04	197	27	3	92f35ea602489efd29ce3a8a186d1f70d65faf40
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE4B KCNA3 ECE1	2.24e-04	197	27	3	b3876076684781fb8384117f2cf367d828985986
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MACF1 PDE4D C1orf21	2.27e-04	198	27	3	a1b310274aa9b3d2aa1fe9488d67422bf4ac81d2
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MACF1 PDE4D C1orf21	2.27e-04	198	27	3	2fdb92b198ba24e326e90479fd024400d956fb32
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	MACF1 PDE4D C1orf21	2.27e-04	198	27	3	a781fd35a7cda8b7760c2e3ddccaac7aac26c979
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MACF1 C1orf21 NLRC3	2.27e-04	198	27	3	c54da37aa11f82a68e591d563b3db9121d6b498f
ToppCell	Severe-Lymphoid-NK\|Severe / Condition, Lineage, Cell class and cell subclass	PDE4D C1orf21 NLRC3	2.27e-04	198	27	3	26b6d20527d22ce68067cdaea6b4330cb779f91b
Computational	Neighborhood of BMPR2	MACF1 ASAP2 ZNF275	3.00e-04	85	17	3	GCM_BMPR2
Drug	M 98	PDE4B PDE4D	1.35e-06	2	27	2	CID006420180
Drug	V11294 Analogue 5f	PDE4B PDE4D	1.35e-06	2	27	2	CID011214587
Drug	V11294 Analogue 5m	PDE4B PDE4D	1.35e-06	2	27	2	CID011477773
Drug	(S)-Rolipram	PDE4B PDE4D	1.35e-06	2	27	2	DB03606
Drug	V11294 Analogue 5i	PDE4B PDE4D	1.35e-06	2	27	2	CID011376249
Drug	V11294 Analogue 5t	PDE4B PDE4D	1.35e-06	2	27	2	CID011226695
Drug	V11294 Analogue 5e	PDE4B PDE4D	1.35e-06	2	27	2	CID011443441
Drug	1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester	PDE4B PDE4D	1.35e-06	2	27	2	ctd:C554440
Drug	V11294 Analogue 5d	PDE4B PDE4D	1.35e-06	2	27	2	CID011283750
Drug	V11294 Analogue 5n	PDE4B PDE4D	1.35e-06	2	27	2	CID011238279
Drug	V11294 Analogue 8a	PDE4B PDE4D	1.35e-06	2	27	2	CID011442865
Drug	3-cyclopentyloxy-4-methoxybenzoic acid	PDE4B PDE4D	1.35e-06	2	27	2	CID002779323
Drug	V11294 Analogue 5r	PDE4B PDE4D	1.35e-06	2	27	2	CID011168555
Drug	V11294 Analogue 5v	PDE4B PDE4D	1.35e-06	2	27	2	CID011375325
Drug	V11294 Analogue 5j	PDE4B PDE4D	1.35e-06	2	27	2	CID011433797
Drug	V11294 Analogue 5q	PDE4B PDE4D	1.35e-06	2	27	2	CID011318772
Drug	V11294 Analogue 5a	PDE4B PDE4D	1.35e-06	2	27	2	CID011386897
Drug	V11294 Analogue 5k	PDE4B PDE4D	1.35e-06	2	27	2	CID011456440
Drug	V11294 Analogue 5p	PDE4B PDE4D	1.35e-06	2	27	2	CID011478659
Drug	3-cyclopentyloxy-4-methoxybenzaldehyde	PDE4B PDE4D	1.35e-06	2	27	2	CID002735893
Drug	V11294 Analogue 5h	PDE4B PDE4D	1.35e-06	2	27	2	CID011306698
Drug	V11294 Analogue 5o	PDE4B PDE4D	1.35e-06	2	27	2	CID011249748
Drug	V11294 Analogue 5c	PDE4B PDE4D	1.35e-06	2	27	2	CID011179896
Drug	V11294 Analogue 5b	PDE4B PDE4D	1.35e-06	2	27	2	CID011443760
Drug	Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid	PDE4B PDE4D	1.35e-06	2	27	2	DB03849
Drug	T-2585.HCl	PDE4B PDE4D	1.35e-06	2	27	2	CID006918355
Drug	3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester	PDE4B PDE4D	1.35e-06	2	27	2	DB01959
Drug	4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone	PDE4B PDE4D	1.35e-06	2	27	2	DB01954
Drug	Np-V	PDE4B PDE4D	1.35e-06	2	27	2	CID009999276
Drug	(R)-Rolipram	PDE4B PDE4D	1.35e-06	2	27	2	DB04149
Drug	Amphotericin B [1397-89-3]; Up 200; 4.4uM; HL60; HT_HG-U133A	NDNF PDE4B PDE4D MYL10 GOLGA1	3.11e-06	196	27	5	2441_UP
Drug	Org 4428	PDE4B PDE4D	4.06e-06	3	27	2	CID000166560
Drug	BW A78U	PDE4B PDE4D	4.06e-06	3	27	2	CID000127779
Drug	1-Pyrrolidinebutanenitrile	PDE4B PDE4D	4.06e-06	3	27	2	CID000118838
Drug	4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid	PDE4B PDE4D	4.06e-06	3	27	2	DB08299
Drug	natrin	KCNA3 RYR1	8.11e-06	4	27	2	CID000019130
Drug	Piclamilast	PDE4B PDE4D	8.11e-06	4	27	2	DB01791
Drug	Caffeine	PDE4B RYR1	8.11e-06	4	27	2	DB00201
Drug	Ibudilast	PDE4B PDE4D	1.35e-05	5	27	2	DB05266
Drug	D-22888	PDE4B PDE4D	1.35e-05	5	27	2	CID000197714
Drug	Cd2366	RARS1 CALU	1.35e-05	5	27	2	CID006443796
Drug	1,7-naphthyridine	PDE4B PDE4D	1.35e-05	5	27	2	CID000009209
Drug	4-methylumbelliferyl phenylphosphonate	PDE4B PDE4D	2.03e-05	6	27	2	CID000134928
Drug	talniflumate	PDE4B PDE4D	2.03e-05	6	27	2	CID000048229
Drug	AC1Q646P	PDE4B PDE4D KCNA3	2.33e-05	47	27	3	CID000005673
Drug	Iloprost	PDE4B PDE4D	2.83e-05	7	27	2	DB01088
Drug	nitraquazone	PDE4B PDE4D	2.83e-05	7	27	2	CID000068765
Drug	Ketotifen	PDE4B PDE4D	2.83e-05	7	27	2	DB00920
Drug	SCH 51866	PDE4B PDE4D	3.78e-05	8	27	2	CID005311355
Drug	KF18280	PDE4B PDE4D	3.78e-05	8	27	2	CID003071941
Drug	bemoradan	PDE4B PDE4D	3.78e-05	8	27	2	CID005362399
Drug	CC-1104	PDE4B PDE4D	3.78e-05	8	27	2	CID000461664
Drug	Dyphylline	PDE4B PDE4D	3.78e-05	8	27	2	DB00651
Drug	L-826,141	PDE4B PDE4D	4.85e-05	9	27	2	ctd:C459562
Drug	trequinsin	PDE4B PDE4D	4.85e-05	9	27	2	ctd:C035964
Drug	2-pyridinemethanol	PDE4B PDE4D	4.85e-05	9	27	2	CID000011474
Drug	AWD 12-281	PDE4B PDE4D	6.06e-05	10	27	2	CID006918428
Drug	NVP ABE171	PDE4B PDE4D	6.06e-05	10	27	2	ctd:C451724
Drug	Tussiglaucin	PDE4B PDE4D	6.06e-05	10	27	2	CID000010145
Drug	Ethaverine hydrochloride [985-13-7]; Up 200; 9.2uM; HL60; HT_HG-U133A	PDE4B ECE1 RYR1 CCDC70	6.67e-05	187	27	4	3037_UP
Drug	Cyclosporin A [59865-13-3]; Up 200; 3.4uM; HL60; HT_HG-U133A	PDE4B PDE4D DNMBP DNM2	6.95e-05	189	27	4	1331_UP
Drug	9-benzyladenine	PDE4B PDE4D	7.40e-05	11	27	2	CID000020262
Drug	V11294	PDE4B PDE4D	7.40e-05	11	27	2	CID009844400
Drug	CP-863187 [668981-07-5]; Down 200; 10uM; PC3; HT_HG-U133A	RARS1 CALU GOLGA1 DNM2	7.69e-05	194	27	4	7558_DN
Drug	Oxyphenbutazone [129-20-4]; Up 200; 12.4uM; PC3; HT_HG-U133A	PDE4B KCNA3 MYL10 ECE1	7.69e-05	194	27	4	4506_UP
Drug	Skimmianine [83-95-4]; Down 200; 15.4uM; HL60; HT_HG-U133A	PDE4B KCNA3 RARS1 GOLGA1	7.69e-05	194	27	4	2504_DN
Drug	Gibberellic acid [77-06-5]; Up 200; 11.6uM; HL60; HT_HG-U133A	NDNF PDE4D MYL10 ECE1	8.32e-05	198	27	4	2910_UP
Drug	arofylline	PDE4B PDE4D	8.87e-05	12	27	2	CID000166553
Drug	naphthoic acid	KCNA3 RARS1	1.05e-04	13	27	2	CID000006847
Drug	1,3-indandione	PDE4B PDE4D	1.05e-04	13	27	2	CID000011815
Drug	Ro 13-6298	RARS1 ECE1	1.05e-04	13	27	2	CID006437076
Drug	Adenosine monophosphate	PDE4B PDE4D	1.22e-04	14	27	2	DB00131
Drug	fenspiride	PDE4B PDE4D	1.22e-04	14	27	2	CID000003344
Drug	trans-permethrin	KCNA3 RARS1 RYR1	1.43e-04	86	27	3	CID000040159
Drug	CDP840	PDE4B PDE4D	1.61e-04	16	27	2	CID000127928
Drug	Roflumilast	PDE4B PDE4D	1.61e-04	16	27	2	ctd:C424423
Drug	Org 9935	PDE4B PDE4D	1.82e-04	17	27	2	CID000131100
Drug	tolafentrine	PDE4B PDE4D	1.82e-04	17	27	2	CID000065990
Drug	8 mm x	PDE4B PDE4D	1.82e-04	17	27	2	CID000155806
Drug	Quazinona	PDE4B PDE4D	1.82e-04	17	27	2	CID000005000
Drug	Cilomilast	PDE4B PDE4D	2.05e-04	18	27	2	ctd:C433247
Drug	RS 67333	PDE4B PDE4D	2.05e-04	18	27	2	CID000183782
Drug	ATBI	PDE4B PDE4D	2.05e-04	18	27	2	CID000505862
Drug	AC1L3XQA	PDE4B PDE4D	2.29e-04	19	27	2	CID000124009
Drug	cipamfylline	PDE4B PDE4D	2.29e-04	19	27	2	CID000071356
Drug	CI-930	PDE4B PDE4D	2.54e-04	20	27	2	CID003021728
Drug	diquafosol	PDE4B PDE4D	2.54e-04	20	27	2	CID000148196
Drug	AA-2379	PDE4B PDE4D	2.80e-04	21	27	2	CID000128390
Drug	flosulide	PDE4B PDE4D	2.80e-04	21	27	2	CID000071246
Drug	siguazodan	PDE4B PDE4D	3.08e-04	22	27	2	CID000072124
Drug	tetomilast	PDE4B PDE4D	3.08e-04	22	27	2	CID003025803
Drug	HWA 153	PDE4B PDE4D	3.08e-04	22	27	2	CID000162797
Drug	compound 30	PDE4B PDE4D	3.08e-04	22	27	2	CID005492232
Drug	griseolic acid	PDE4B PDE4D	3.37e-04	23	27	2	CID000127607
Drug	atherosperminine	PDE4B PDE4D	3.37e-04	23	27	2	CID000096918
Drug	PDEs	PDE4B PDE4D CALU	3.45e-04	116	27	3	CID003036959
Drug	denbufylline	PDE4B PDE4D	3.68e-04	24	27	2	CID000002984
Drug	Ro 15-2041	PDE4B PDE4D	4.32e-04	26	27	2	CID000132434
Drug	Kn 04	KCNA3 RYR1	4.32e-04	26	27	2	CID000131117
Drug	desethyl KBT-3022	PDE4B PDE4D	4.32e-04	26	27	2	CID000127736
Disease	Autosomal Dominant Myotubular Myopathy	RYR1 DNM2	5.34e-05	13	25	2	C3661489
Disease	Centronuclear myopathy	RYR1 DNM2	5.34e-05	13	25	2	C0175709
Disease	Congenital Structural Myopathy	RYR1 DNM2	5.34e-05	13	25	2	C0752282
Disease	X-linked centronuclear myopathy	RYR1 DNM2	5.34e-05	13	25	2	C0410203
Disease	Myopathy, Centronuclear, 1	RYR1 DNM2	5.34e-05	13	25	2	C4551952
Disease	Myopathy, Centronuclear, Autosomal Dominant	RYR1 DNM2	6.23e-05	14	25	2	C1834558
Disease	Tubular Aggregate Myopathy	RYR1 DNM2	6.23e-05	14	25	2	C0410207
Disease	Autosomal Recessive Centronuclear Myopathy	RYR1 DNM2	7.19e-05	15	25	2	C3645536
Disease	Congenital Fiber Type Disproportion	RYR1 DNM2	1.05e-04	18	25	2	C0546264
Disease	sphingomyelin 24:1 measurement	PDE4D CCDC70	1.72e-04	23	25	2	EFO_0010398
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian carcinoma	PDE4B PDE4D	5.01e-04	39	25	2	EFO_0001075, EFO_0004920, GO_0097328, MONDO_0009354
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian serous carcinoma	PDE4B PDE4D	5.81e-04	42	25	2	EFO_0004920, EFO_1001516, GO_0097328, MONDO_0009354
Disease	acute lymphoblastic leukemia	PDE4B KCNA3	1.43e-03	66	25	2	EFO_0000220
Disease	Amphetamine Abuse	PDE4B PDE4D	1.84e-03	75	25	2	C0236807
Disease	Amphetamine Addiction	PDE4B PDE4D	1.84e-03	75	25	2	C0236804
Disease	Amphetamine-Related Disorders	PDE4B PDE4D	1.84e-03	75	25	2	C0236733
Disease	Asthma	PDE4B PDE4D	2.09e-03	80	25	2	C0004096
Disease	susceptibility to shingles measurement	PDE4D ZBTB7C	2.14e-03	81	25	2	EFO_0008401
Disease	sunburn	PDE4B PDE4D	2.99e-03	96	25	2	EFO_0003958

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVQFFIERERDMEIA	C2orf78	901	A6NCI8
EDFVDVIGFRMKDLR	ADGRB1	746	O14514
EVFEETEKNFRMQER	DNMBP	1021	Q6XZF7
QFVEFRDKNRDGKMD	CALU	236	O43852
QEEKAFREEMKIFRE	CCDC70	46	Q6NSX1
MNLFQRRDEMDELEG	GOLGA1	161	Q92805
DRMTEIRGFNEEEIK	NLRC3	281	Q7RTR2
AEIAEEMEKERRFFQ	ASAP2	181	O43150
RIMEEFFQQGDKERE	PDE4B	581	Q07343
FFQQGDKERERGMEI	PDE4B	586	Q07343
EFFRQGDRERERGME	PDE4D	641	Q08499
EEAMEKFREDEGFLR	KCNA3	191	P22001
DEELFQMQIRDKAFF	NDNF	26	Q8TB73
MDQNRDGFIDKEDLR	MYL10	96	Q9BUA6
QMVQQFGVDFEKRIE	DNM2	331	P50570
VMDFFRRIDKDQDGK	MACF1	7046	Q9UPN3
QQEFFRMLDEKIEKG	C1orf21	96	Q9H246
AERAQKRMENEDVFG	MARF1	561	Q9Y4F3
LDQRFQDADEKFMEV	ECE1	406	P42892
ERFFEKMDRNQDGVV	KCNIP3	216	Q9Y2W7
FGELRDQQEQVKEDM	RYR1	4941	P21817
RMNDIVKEFEDRGFV	RARS1	341	P54136
DKERGEIEVDIQFMR	RAB11FIP1	136	Q6WKZ4
IVKGMVERFNDDFIE	SNX7	101	Q9UNH6
QERKFMEERELLGQD	RSPH3	531	Q86UC2
EERDQRQMIKEAFAG	UTP14C	586	Q5TAP6
ELERQFEETQMKLFG	ZBTB7C	546	A1YPR0
REQMEREAKPFECEE	ZNF275	171	Q9NSD4