Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	retromer complex binding	WASHC2C WASHC2A	3.43e-04	10	56	2	GO:1905394
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	N4BP2 CHD7 XRCC4 MPG DNTT	8.28e-04	262	56	5	GO:0140097
GeneOntologyMolecularFunction	phosphatidylinositol-5-phosphate binding	WASHC2C WASHC2A	1.88e-03	23	56	2	GO:0010314
GeneOntologyMolecularFunction	zinc ion binding	HHIP MARCHF10 RC3H1 GATA4 ZNF638 MYRIP ZMYM4 ZFPM2	3.24e-03	891	56	8	GO:0008270
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate binding	WASHC2C WASHC2A	3.41e-03	31	56	2	GO:0080025
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	PLEKHG6 FGD5 DENND3 FARP2	4.00e-03	231	56	4	GO:0005085
GeneOntologyMolecularFunction	phosphatidylinositol-3,4-bisphosphate binding	WASHC2C WASHC2A	4.33e-03	35	56	2	GO:0043325
GeneOntologyMolecularFunction	phosphatidylinositol-4-phosphate binding	WASHC2C WASHC2A	4.58e-03	36	56	2	GO:0070273
GeneOntologyMolecularFunction	transcription coregulator activity	TAF6L NKX2-1 SMARCD2 SSX6P SSX8P ZFPM2	4.77e-03	562	56	6	GO:0003712
GeneOntologyBiologicalProcess	cardiac right ventricle morphogenesis	BMP4 GATA4 CHD7 ZFPM2	2.82e-07	21	56	4	GO:0003215
GeneOntologyBiologicalProcess	cardiac septum morphogenesis	BMP4 GATA4 FGFRL1 CHD7 ZFPM2	4.29e-06	89	56	5	GO:0060411
GeneOntologyBiologicalProcess	respiratory system development	BMP4 HHIP NKX2-1 GATA4 FGFRL1 CHD7 ZFPM2	1.80e-05	305	56	7	GO:0060541
GeneOntologyBiologicalProcess	right ventricular cardiac muscle tissue morphogenesis	CHD7 ZFPM2	2.17e-05	3	56	2	GO:0003221
GeneOntologyBiologicalProcess	heart valve morphogenesis	BMP4 GATA4 FGFRL1 ZFPM2	2.58e-05	63	56	4	GO:0003179
GeneOntologyBiologicalProcess	cardiac septum development	BMP4 GATA4 FGFRL1 CHD7 ZFPM2	3.14e-05	134	56	5	GO:0003279
GeneOntologyBiologicalProcess	tricuspid valve formation	GATA4 ZFPM2	4.33e-05	4	56	2	GO:0003195
GeneOntologyBiologicalProcess	heart valve development	BMP4 GATA4 FGFRL1 ZFPM2	5.99e-05	78	56	4	GO:0003170
GeneOntologyBiologicalProcess	mitral valve formation	GATA4 ZFPM2	7.20e-05	5	56	2	GO:0003192
GeneOntologyBiologicalProcess	cardiac chamber morphogenesis	BMP4 GATA4 FGFRL1 CHD7 ZFPM2	7.54e-05	161	56	5	GO:0003206
GeneOntologyBiologicalProcess	cardiac ventricle development	BMP4 GATA4 FGFRL1 CHD7 ZFPM2	7.54e-05	161	56	5	GO:0003231
GeneOntologyBiologicalProcess	cardiac ventricle morphogenesis	BMP4 GATA4 CHD7 ZFPM2	9.59e-05	88	56	4	GO:0003208
GeneOntologyBiologicalProcess	ventricular septum development	BMP4 GATA4 FGFRL1 ZFPM2	1.09e-04	91	56	4	GO:0003281
GeneOntologyBiologicalProcess	muscle organ morphogenesis	BMP4 GATA4 CHD7 ZFPM2	1.70e-04	102	56	4	GO:0048644
GeneOntologyBiologicalProcess	tricuspid valve morphogenesis	GATA4 ZFPM2	2.01e-04	8	56	2	GO:0003186
GeneOntologyBiologicalProcess	tricuspid valve development	GATA4 ZFPM2	2.57e-04	9	56	2	GO:0003175
GeneOntologyBiologicalProcess	atrioventricular valve formation	GATA4 ZFPM2	2.57e-04	9	56	2	GO:0003190
GeneOntologyBiologicalProcess	cardiac chamber development	BMP4 GATA4 FGFRL1 CHD7 ZFPM2	2.73e-04	212	56	5	GO:0003205
GeneOntologyBiologicalProcess	protein-DNA complex organization	TAF6L BDP1 PADI4 SUDS3 PWWP3A SMARCD2 PPHLN1 CHD7 SPOCD1 NFAT5	3.17e-04	999	56	10	GO:0071824
GeneOntologyBiologicalProcess	diaphragm development	GATA4 FGFRL1	4.70e-04	12	56	2	GO:0060539
GeneOntologyBiologicalProcess	ventricular septum morphogenesis	BMP4 FGFRL1 ZFPM2	4.75e-04	56	56	3	GO:0060412
GeneOntologyCellularComponent	chromatin	TAF6L NKX2-1 SUDS3 BHLHA15 AHCTF1 GATA4 SMARCD2 POU3F3 CHD7 NFAT5 PRAMEF26 ZFPM2 DNTT	9.34e-05	1480	55	13	GO:0000785
HumanPheno	Primary gonadal insufficiency	GATA4 XRCC4 ZFPM2	2.04e-05	17	17	3	HP:0008193
MousePheno	lethality throughout fetal growth and development	BMP4 WASHC2C PKD1L1 GATA4 FGFRL1 CHD7 XRCC4 WASHC2A NFAT5 ZFPM2	7.38e-07	435	44	10	MP:0006208
MousePheno	lethality throughout fetal growth and development, complete penetrance	WASHC2C PKD1L1 GATA4 XRCC4 WASHC2A NFAT5 ZFPM2	1.63e-05	263	44	7	MP:0011099
MousePheno	lethality during fetal growth through weaning, complete penetrance	BMP4 HHIP CCDC8 WASHC2C NKX2-1 RC3H1 PKD1L1 GATA4 FGFRL1 POU3F3 XRCC4 WASHC2A NFAT5 ZFPM2	2.04e-05	1269	44	14	MP:0011111
MousePheno	heart right ventricle outflow tract stenosis	GATA4 FGFRL1 ZFPM2	2.72e-05	19	44	3	MP:0010449
MousePheno	abnormal apoptosis	BMP4 RCAN1 FCGR2A TOPAZ1 AHCTF1 GATA4 FGFRL1 POU3F3 CHD7 XRCC4 SPOCD1 NFAT5 PRAMEF26 MPG	4.19e-05	1353	44	14	MP:0001648
MousePheno	abnormal gland physiology	HHIP RCAN1 FCGR2A NKX2-1 BHLHA15 GATA4 MYRIP CHD7 SPOCD1 MPG	4.39e-05	691	44	10	MP:0002164
MousePheno	abnormal programmed cell death	BMP4 RCAN1 FCGR2A TOPAZ1 AHCTF1 GATA4 FGFRL1 POU3F3 CHD7 XRCC4 SPOCD1 NFAT5 PRAMEF26 MPG	4.43e-05	1360	44	14	MP:0014355
MousePheno	absent coronary vessels	GATA4 ZFPM2	5.79e-05	4	44	2	MP:0010561
MousePheno	abnormal gland development	BMP4 HHIP NKX2-1 BHLHA15 RC3H1 CHD7	8.35e-05	233	44	6	MP:0020973
MousePheno	true hermaphroditism	GATA4 ZFPM2	9.62e-05	5	44	2	MP:0002213
MousePheno	abnormal incus short process morphology	POU3F3 CHD7	9.62e-05	5	44	2	MP:0030394
MousePheno	thick semilunar valve	GATA4 FGFRL1 ZFPM2	1.11e-04	30	44	3	MP:0031584
MousePheno	abnormal foregut morphology	BMP4 NKX2-1 GATA4	1.11e-04	30	44	3	MP:0000474
MousePheno	abnormal respiratory system development	NKX2-1 RC3H1 GATA4 CHD7 ZFPM2	1.40e-04	160	44	5	MP:0003115
MousePheno	thin myocardium	GATA4 FGFRL1 CHD7 ZFPM2	1.44e-04	85	44	4	MP:0002652
MousePheno	delayed estrous cycle	GATA4 CHD7	1.44e-04	6	44	2	MP:0009008
MousePheno	abnormal pituitary diverticulum morphology	BMP4 NKX2-1 CHD7	1.93e-04	36	44	3	MP:0003817
MousePheno	decreased lateral semicircular canal size	BMP4 CHD7	2.01e-04	7	44	2	MP:0003162
MousePheno	abnormal adenohypophysis development	BMP4 NKX2-1 CHD7	2.27e-04	38	44	3	MP:0013337
MousePheno	abnormal pituitary gland development	BMP4 NKX2-1 CHD7	3.07e-04	42	44	3	MP:0003816
MousePheno	increased kidney apoptosis	FGFRL1 POU3F3 NFAT5	3.29e-04	43	44	3	MP:0011368
MousePheno	decreased kidney cell proliferation	FGFRL1 POU3F3	3.44e-04	9	44	2	MP:0011441
MousePheno	abnormal pulmonary valve morphology	GATA4 FGFRL1 ZFPM2	3.76e-04	45	44	3	MP:0002748
MousePheno	abnormal fetal cardiomyocyte proliferation	GATA4 CHD7 NFAT5	4.56e-04	48	44	3	MP:0003567
MousePheno	abnormal heart right ventricle outflow tract morphology	GATA4 FGFRL1 ZFPM2	6.11e-04	53	44	3	MP:0010428
MousePheno	abnormal kidney apoptosis	FGFRL1 POU3F3 NFAT5	6.11e-04	53	44	3	MP:0011367
MousePheno	primary sex reversal	GATA4 ZFPM2	6.26e-04	12	44	2	MP:0002995
MousePheno	abnormal fetal cardiomyocyte physiology	GATA4 CHD7 NFAT5	6.81e-04	55	44	3	MP:0011390
MousePheno	common atrioventricular valve	GATA4 ZFPM2	7.39e-04	13	44	2	MP:0010607
MousePheno	pulmonary valve stenosis	GATA4 FGFRL1	7.39e-04	13	44	2	MP:0006128
MousePheno	absent lateral semicircular canal	BMP4 CHD7	7.39e-04	13	44	2	MP:0003161
MousePheno	abnormal cardiac muscle tissue morphology	BMP4 RCAN1 GATA4 FGFRL1 CHD7 NFAT5 ZFPM2	7.65e-04	489	44	7	MP:0010630
MousePheno	abnormal pulmonary trunk morphology	CHD7 ZFPM2	8.60e-04	14	44	2	MP:0000486
Domain	FAM21	WASHC2C WASHC2A	8.21e-06	2	54	2	IPR027308
Domain	FAM21/CAPZIP	WASHC2C WASHC2A	2.46e-05	3	54	2	IPR029341
Domain	CAP-ZIP_m	WASHC2C WASHC2A	2.46e-05	3	54	2	PF15255
Domain	KRAB_RELATED	SSX6P SSX8P	4.44e-04	11	54	2	PS50806
Domain	-	CDC42SE2 CDC42SE1	5.32e-04	12	54	2	3.90.810.10
Domain	Krueppel-associated_box-rel	SSX6P SSX8P	6.27e-04	13	54	2	IPR003655
Domain	RhoGEF	PLEKHG6 FGD5 FARP2	1.00e-03	68	54	3	SM00325
Domain	RhoGEF	PLEKHG6 FGD5 FARP2	1.09e-03	70	54	3	PF00621
Domain	DH_2	PLEKHG6 FGD5 FARP2	1.09e-03	70	54	3	PS50010
Domain	DH-domain	PLEKHG6 FGD5 FARP2	1.14e-03	71	54	3	IPR000219
Domain	-	PLEKHG6 FGD5 FARP2	1.14e-03	71	54	3	1.20.900.10
Domain	CRIB	CDC42SE2 CDC42SE1	1.51e-03	20	54	2	PS50108
Domain	CRIB_dom	CDC42SE2 CDC42SE1	1.66e-03	21	54	2	IPR000095
Domain	AT_hook	AHCTF1 SCML4	2.75e-03	27	54	2	SM00384
Domain	AT_hook_DNA-bd_motif	AHCTF1 SCML4	2.75e-03	27	54	2	IPR017956
Domain	ZF_FYVE	MYRIP FGD5	5.97e-03	40	54	2	PS50178
Domain	SANT	BDP1 CHD7	9.20e-03	50	54	2	SM00717
Domain	SANT/Myb	BDP1 CHD7	9.92e-03	52	54	2	IPR001005
Pathway	REACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM	BMP4 GATA4	8.21e-05	5	41	2	M46432
Pathway	KEGG_MEDICUS_REFERENCE_V_D_J_RECOMBINATION	XRCC4 DNTT	5.35e-04	12	41	2	M47856
Pathway	KEGG_MEDICUS_REFERENCE_NON_HOMOLOGOUS_END_JOINING	XRCC4 DNTT	6.31e-04	13	41	2	M47837
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_TESTIS_DIFFERENTIATION	GATA4 ZFPM2	6.31e-04	13	41	2	M41725
Pathway	KEGG_NON_HOMOLOGOUS_END_JOINING	XRCC4 DNTT	6.31e-04	13	41	2	M7857
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	AHCTF1 GATA4 ZNF638 SMARCD2 PPHLN1 CHD7 ZMYM4 ZFPM2	3.08e-07	411	56	8	35182466
Pubmed	Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6.	BMP4 GATA4 ZFPM2	1.12e-06	13	56	3	12606287
Pubmed	NKX2.1 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells.	BMP4 NKX2-1	2.55e-06	2	56	2	14960358
Pubmed	SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4.	GATA4 ZFPM2	2.55e-06	2	56	2	23226341
Pubmed	Identification of a novel Rev-interacting cellular protein.	WASHC2C WASHC2A	2.55e-06	2	56	2	15847701
Pubmed	Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes.	GATA4 ZFPM2	2.55e-06	2	56	2	9927675
Pubmed	Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).	WASHC2C WASHC2A	2.55e-06	2	56	2	20827171
Pubmed	FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.	WASHC2C WASHC2A	2.55e-06	2	56	2	36717248
Pubmed	Novel missense variants of ZFPM2/FOG2 identified in conotruncal heart defect patients do not impair interaction with GATA4.	GATA4 ZFPM2	2.55e-06	2	56	2	25025186
Pubmed	Identification of ZFPM2 mutations in sporadic conotruncal heart defect patients.	GATA4 ZFPM2	2.55e-06	2	56	2	29018978
Pubmed	An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif.	GATA4 ZFPM2	2.55e-06	2	56	2	17445768
Pubmed	GATA-4 and FOG-2 expression in pediatric ovarian sex cord-stromal tumors replicates embryonal gonadal phenotype: results from the TREP project.	GATA4 ZFPM2	2.55e-06	2	56	2	23029311
Pubmed	The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse.	CDC42SE2 CDC42SE1	2.55e-06	2	56	2	15840583
Pubmed	Analysis of variants in GATA4 and FOG2/ZFPM2 demonstrates benign contribution to 46,XY disorders of sex development.	GATA4 ZFPM2	2.55e-06	2	56	2	31962012
Pubmed	Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis.	BMP4 NKX2-1 GATA4	5.15e-06	21	56	3	32855417
Pubmed	A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription.	GATA4 ZFPM2	7.63e-06	3	56	2	10801815
Pubmed	Cardiac expression of Tnnt1 requires the GATA4-FOG2 transcription complex.	GATA4 ZFPM2	7.63e-06	3	56	2	19578715
Pubmed	Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes.	GATA4 ZFPM2	7.63e-06	3	56	2	18252717
Pubmed	Loss-of-function mutation in GATA4 causes anomalies of human testicular development.	GATA4 ZFPM2	7.63e-06	3	56	2	21220346
Pubmed	Gata4 is necessary for normal pulmonary lobar development.	GATA4 ZFPM2	7.63e-06	3	56	2	17142311
Pubmed	GATA6 is a crucial regulator of Shh in the limb bud.	BMP4 GATA4 ZFPM2	1.00e-05	26	56	3	24415953
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	N4BP2 AHCTF1 ZNF638 SMARCD2 CHD7 ZMYM4 ZFPM2	1.02e-05	469	56	7	27634302
Pubmed	Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme.	BMP4 HHIP NKX2-1	1.26e-05	28	56	3	18367557
Pubmed	A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification.	BMP4 NKX2-1 GATA4	1.40e-05	29	56	3	27320915
Pubmed	Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.	BMP4 GATA4 SMARCD2	1.40e-05	29	56	3	15525990
Pubmed	Human transcription factor protein interaction networks.	TAF6L CCDC8 SUDS3 RC3H1 GATA4 ZNF638 SMARCD2 CHD7 WASHC2A ZMYM4 ZFPM2	1.47e-05	1429	56	11	35140242
Pubmed	Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis.	GATA4 ZFPM2	1.52e-05	4	56	2	12213678
Pubmed	Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.	GATA4 ZFPM2	1.52e-05	4	56	2	24743694
Pubmed	FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression.	GATA4 ZFPM2	1.52e-05	4	56	2	12606418
Pubmed	Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development.	GATA4 ZFPM2	1.52e-05	4	56	2	14614148
Pubmed	Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects.	BMP4 GATA4	1.52e-05	4	56	2	18076106
Pubmed	SPECs, small binding proteins for Cdc42.	CDC42SE2 CDC42SE1	1.52e-05	4	56	2	10816584
Pubmed	[Association of single nucleotide polymorphisms of transcription factors with congenital heart diseases in the Chinese population: a Meta analysis].	GATA4 ZFPM2	1.52e-05	4	56	2	29972125
Pubmed	Altered gene expression with abnormal patterning of the telencephalon in embryos of diabetic Albino Swiss mice.	BMP4 NKX2-1	1.52e-05	4	56	2	14963649
Pubmed	New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle.	GATA4 ZFPM2	2.54e-05	5	56	2	20807224
Pubmed	The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.	GATA4 ZFPM2	2.54e-05	5	56	2	20206639
Pubmed	Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cells.	BMP4 GATA4	2.54e-05	5	56	2	9857019
Pubmed	Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis.	BMP4 HHIP	2.54e-05	5	56	2	15013801
Pubmed	CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms.	GATA4 CHD7	3.80e-05	6	56	2	35129866
Pubmed	Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors.	GATA4 ZFPM2	3.80e-05	6	56	2	11297508
Pubmed	GATA-4:FOG interactions regulate gastric epithelial development in the mouse.	GATA4 ZFPM2	3.80e-05	6	56	2	16127717
Pubmed	Epithelial inactivation of Yy1 abrogates lung branching morphogenesis.	BMP4 HHIP NKX2-1	4.66e-05	43	56	3	26329601
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	TAF6L PWWP3A SMARCD2 PPHLN1 CHD7 ZMYM4	5.11e-05	410	56	6	26949251
Pubmed	Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element.	BMP4 GATA4	5.32e-05	7	56	2	15987774
Pubmed	GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development.	GATA4 ZFPM2	5.32e-05	7	56	2	18577233
Pubmed	Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome.	FCGR2A GATA4	5.32e-05	7	56	2	22431569
Pubmed	Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2.1 and Pten.	BMP4 NKX2-1	5.32e-05	7	56	2	18602626
Pubmed	Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.	BMP4 GATA4	5.32e-05	7	56	2	16624858
Pubmed	Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage.	BMP4 NKX2-1	5.32e-05	7	56	2	20034104
Pubmed	Regulation of the Pancreatic Exocrine Differentiation Program and Morphogenesis by Onecut 1/Hnf6.	BHLHA15 GATA4	5.32e-05	7	56	2	30831323
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	NKX2-1 AHCTF1 GATA4 SMARCD2 CHD7 ZMYM4 MPG	5.32e-05	608	56	7	36089195
Pubmed	Congenital Diaphragmatic Hernia Overview	GATA4 CHD7 ZFPM2	5.71e-05	46	56	3	20301533
Pubmed	A FAM21-containing WASH complex regulates retromer-dependent sorting.	WASHC2C WASHC2A	7.09e-05	8	56	2	19922874
Pubmed	A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2.	GATA4 ZFPM2	7.09e-05	8	56	2	10888889
Pubmed	Enhancer-promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness.	NKX2-1 GATA4	7.09e-05	8	56	2	36717694
Pubmed	Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres.	BMP4 NKX2-1	7.09e-05	8	56	2	10498272
Pubmed	Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome.	GATA4 CHD7	7.09e-05	8	56	2	29311329
Pubmed	Sonic hedgehog is essential to foregut development.	BMP4 NKX2-1	7.09e-05	8	56	2	9731532
Pubmed	Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.	BMP4 ZFPM2	9.10e-05	9	56	2	10225993
Pubmed	Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3.	BMP4 GATA4	9.10e-05	9	56	2	28484278
Pubmed	Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects.	GATA4 ZFPM2	9.10e-05	9	56	2	17069789
Pubmed	Formation of Rathke's pouch requires dual induction from the diencephalon.	BMP4 NKX2-1	9.10e-05	9	56	2	9806931
Pubmed	Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome.	BMP4 CHD7	9.10e-05	9	56	2	21596839
Pubmed	Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression.	SSX6P SSX8P	9.10e-05	9	56	2	14611804
Pubmed	Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development.	HHIP GATA4 ZFPM2	9.25e-05	54	56	3	15533830
Pubmed	The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development.	GATA4 ZFPM2	1.14e-04	10	56	2	23836893
Pubmed	Deletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality.	BMP4 GATA4	1.14e-04	10	56	2	22046433
Pubmed	The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.	BMP4 GATA4	1.14e-04	10	56	2	9420335
Pubmed	The mutation in Chd7 causes misexpression of Bmp4 and developmental defects in telencephalic midline.	BMP4 CHD7	1.14e-04	10	56	2	22658483
Pubmed	The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models.	GATA4 ZFPM2	1.14e-04	10	56	2	17540364
Pubmed	Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles.	BMP4 NKX2-1	1.14e-04	10	56	2	11955708
Pubmed	Y chromosome damage underlies testicular abnormalities in ATR-X syndrome.	GATA4 ZFPM2	1.39e-04	11	56	2	38616920
Pubmed	Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning.	HHIP NKX2-1	1.39e-04	11	56	2	17442700
Pubmed	Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression.	BMP4 NKX2-1	1.39e-04	11	56	2	32778568
Pubmed	CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice.	GATA4 CHD7	1.39e-04	11	56	2	24293546
Pubmed	Linx mediates interaxonal interactions and formation of the internal capsule.	NKX2-1 ZFPM2	1.39e-04	11	56	2	24930700
Pubmed	Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung.	BMP4 HHIP	1.39e-04	11	56	2	12569124
Pubmed	Spatially resolved whole transcriptome profiling in human and mouse tissue using Digital Spatial Profiling.	NKX2-1 GATA4	1.39e-04	11	56	2	36100434
Pubmed	Congenital diaphragmatic hernia: comparison of animal models and relevance to the human situation.	GATA4 ZFPM2	1.66e-04	12	56	2	19325248
Pubmed	The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.	WASHC2C WASHC2A	1.66e-04	12	56	2	19922875
Pubmed	Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.	WASHC2C WASHC2A	1.66e-04	12	56	2	27390154
Pubmed	Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development.	BMP4 NKX2-1	1.66e-04	12	56	2	21482757
Pubmed	Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.	BMP4 HHIP	1.66e-04	12	56	2	10981962
Pubmed	Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice.	GATA4 ZFPM2	1.66e-04	12	56	2	17848526
Pubmed	Wnt5a participates in distal lung morphogenesis.	BMP4 NKX2-1	1.66e-04	12	56	2	12142021
Pubmed	Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos.	BMP4 NKX2-1	1.66e-04	12	56	2	10208743
Pubmed	RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects.	BMP4 GATA4	1.66e-04	12	56	2	30061196
Pubmed	Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung.	BMP4 NKX2-1	1.96e-04	13	56	2	15907834
Pubmed	GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo.	BMP4 NKX2-1	1.96e-04	13	56	2	17164424
Pubmed	Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps.	BMP4 NKX2-1	1.96e-04	13	56	2	16916379
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	TAF6L URB1 SUDS3 AHCTF1 ZNF638 PPHLN1 CHD7 ZMYM4 MPG	2.08e-04	1294	56	9	30804502
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	AHCTF1 GATA4 SMARCD2 CHD7	2.20e-04	183	56	4	36129980
Pubmed	Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis.	BMP4 GATA4	2.29e-04	14	56	2	17075876
Pubmed	Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.	BMP4 GATA4	2.29e-04	14	56	2	19084512
Pubmed	beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis.	BMP4 NKX2-1	2.29e-04	14	56	2	12885771
Pubmed	Sonic hedgehog regulates branching morphogenesis in the mammalian lung.	BMP4 NKX2-1	2.29e-04	14	56	2	9768363
Pubmed	Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice.	BMP4 NKX2-1	2.29e-04	14	56	2	16766714
Pubmed	NOX2 Is Critical to Endocardial to Mesenchymal Transition and Heart Development.	BMP4 GATA4	2.29e-04	14	56	2	32655758
Pubmed	Chordin and noggin promote organizing centers of forebrain development in the mouse.	BMP4 NKX2-1	2.29e-04	14	56	2	12397106
Pubmed	Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium.	BMP4 GATA4	2.29e-04	14	56	2	17855431
Cytoband	1q25.1	RC3H1 XPR1	8.00e-04	34	56	2	1q25.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1q25	RGSL1 RC3H1 XPR1	1.14e-03	167	56	3	chr1q25
GeneFamily	WASH complex	WASHC2C WASHC2A	6.42e-05	6	38	2	1331
Computational	Genes upregulated in subsets of cells of a given type within various tumors	BDP1 AHCTF1 ZNF638 ZMYM4	1.19e-05	50	31	4	GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
Disease	Diaphragmatic Hernia	BMP4 NKX2-1 GATA4 ZFPM2	8.27e-07	41	52	4	C0019284
Disease	Congenital diaphragmatic hernia	GATA4 FGFRL1 ZFPM2	6.71e-06	21	52	3	C0235833
Disease	Tetralogy of Fallot	GATA4 ZFPM2	4.55e-05	6	52	2	cv:C0039685
Disease	TETRALOGY OF FALLOT	GATA4 ZFPM2	4.55e-05	6	52	2	187500
Disease	atrial heart septal defect (is_implicated_in)	BMP4 GATA4	6.36e-05	7	52	2	DOID:1882 (is_implicated_in)
Disease	colorectal cancer, colorectal adenoma	BMP4 HHIP PLEKHG6 HAO1	1.51e-04	152	52	4	EFO_0005406, MONDO_0005575
Disease	46,XY partial gonadal dysgenesis	GATA4 ZFPM2	1.66e-04	11	52	2	C4510744
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	GATA4 ZFPM2	1.99e-04	12	52	2	DOID:3827 (implicated_via_orthology)
Disease	tetralogy of Fallot (is_implicated_in)	GATA4 ZFPM2	2.35e-04	13	52	2	DOID:6419 (is_implicated_in)
Disease	Rheumatoid Arthritis	BMP4 PADI4 RCAN1 FCGR2A	2.54e-04	174	52	4	C0003873
Disease	Tetralogy of Fallot	GATA4 ZFPM2	3.60e-04	16	52	2	C0039685
Disease	Congenital hernia of foramen of Morgagni	GATA4 FGFRL1	5.11e-04	19	52	2	C0265699
Disease	Congenital hernia of foramen of Bochdalek	GATA4 FGFRL1	5.11e-04	19	52	2	C0265700
Disease	Brugada syndrome	GATA4 ZFPM2	5.11e-04	19	52	2	MONDO_0015263
Disease	gallstones	GATA4 NFAT5 FARP2	9.25e-04	108	52	3	EFO_0004210

Protein segments in the cluster

Peptide	Gene	Start	Entry
ENVKPMLRGRFQRPK	BDP1	606	A6H8Y1
MLRGRFQRPKPNLSR	BDP1	611	A6H8Y1
NKVLPMRRVLRKRPS	CDHR1	731	Q96JP9
PQPKKKRRRIDRTMI	CDC42SE1	16	Q9NRR8
PPGRQMIAIRKRQLE	FCGR2A	261	P12318
MKTKNRPPRRRAPVQ	BHLHA15	1	Q7RTS1
MRSLRKKREKPRPEQ	DENND3	1	A2RUS2
LLQMFGLRRRPQPSK	BMP4	61	P12644
EPPMKRRRGRRKNVE	CHD7	2506	Q9P2D1
KNMAPLPSAPRRKRR	NKX2-1	151	P43699
FRKMNKRLVPRRPLS	RC3H1	446	Q5TC82
MRRPKPKIIQTRRPE	RCAN1	231	P53805
PRNRGLKEFPIKRVM	PADI4	371	Q9UM07
RKPRVKRPQLMQQVH	MBTPS1	1031	Q14703
MSRRKQSKPRQIKRP	ZFPM2	1	Q8WW38
PQPKRRRRIDRSMIG	CDC42SE2	16	Q9NRR3
QPSKMRRRVIARPVG	FGFRL1	151	Q8N441
KKRGRAVPGLMRERP	FGD5	1301	Q6ZNL6
VRNRFKLPPQLRMKN	HAO1	171	Q9UJM8
KRRRRRKKQVGPEMG	MIGA2	66	Q7L4E1
SRKRNPKQRPGVKRR	NFAT5	201	O94916
LVKAVLPGMKRRRQG	RDH8	121	Q9NYR8
RPRKLTRAQLQRMRG	PLEKHG6	761	Q3KR16
KMNGINRPLIKPQRR	GATA4	246	P43694
RRMGQKKQRPARAGQ	MPG	16	P29372
APMVLLRKRKPNLRR	MARCHF10	131	Q8NA82
DMSAIPRKRGRPRKI	AHCTF1	1966	Q8WYP5
PMKPIIRQIRRPKNV	FARP2	101	O94887
KKPKEPRVRRRVQQM	CCDC8	71	Q9H0W5
NRRQKEKRMTPPGIQ	POU3F3	456	P20264
PPSKAQLRGTRQRMR	PKD1L1	2261	Q8TDX9
RNKKPVQDCPRMRGR	PRAMEF26	36	H0Y7S4
QAPQPLQPRKKRVRR	PPHLN1	381	Q8NEY8
GQRQPCRKMLPDRSR	PWWP3A	551	Q2TAK8
QKLPMIGRTSRPARR	TAF6L	596	Q9Y6J9
LKRTLVRKPSMRPRN	RGSL1	631	A5PLK6
PRKKRPRQTGALMAS	DNTT	11	P04053
QRMKALARALPLQPR	STARD9	2201	Q9P2P6
APPRAARNRPCKRKM	NPAP1	316	Q9NZP6
NGNPPKRLKRRDRRM	HHIP	41	Q96QV1
VMPARAKGPRGRKRR	URB1	2021	O60287
GVRRTRPSRKGKRLM	OSM	231	P13725
RPSRKGKRLMTRGQL	OSM	236	P13725
PPMPAQRRGLKRRKM	SMARCD2	126	Q92925
RQKAMKRLRVPPLGA	XPR1	211	Q9UBH6
RPQMTFGRLQRIIPK	SSX6P	96	Q7RTT6
RPQMTFGRLQRIIPK	SSX8P	96	Q7RTT4
AQRLRRKKRPMVQGP	SPOCD1	516	Q6ZMY3
KRRQRMQRNLGTEPK	XRCC4	271	Q13426
VKMRGKRRPQTRAAR	WASHC2C	1011	Q9Y4E1
NKQKRRMVARATPGR	TOPAZ1	46	Q8N9V7
RVKMRGKRRPQTRAA	WASHC2A	1031	Q641Q2
EVKPIMTRKLRRRPN	SUDS3	176	Q9H7L9
MQSQRIPGRKRGRPS	SCML4	1	Q8N228
DIRMRKMGRRLPNLP	ZNF638	176	Q14966
PQPRRRGRKKSIVAV	ZMYM4	1171	Q5VZL5
MPRRRKNLGGNPFRK	N4BP2	1	Q86UW6
QRKAPRNPAAEKMRL	MYRIP	476	Q8NFW9