Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP hydrolysis activity

PMS2P1 KIF27 RTEL1 PSMC2 PSMC3 ATAD2 MLH3 ATAD2B KIF19 ABCD2 ATP2A2 ATP2B1

3.54e-0644110512GO:0016887
GeneOntologyMolecularFunctionATP-dependent activity

PMS2P1 KIF27 RTEL1 PSMC2 PSMC3 ATAD2 MLH3 ATAD2B KIF19 ABCD2 ATP2A2 ATP2B1

9.25e-0561410512GO:0140657
DomainARM-type_fold

ZYG11A CAND2 ARMC3 IFT172 UBR4 NCDN DIAPH1 ULK4 MMS19 GCN1 HTT SYMPK

4.08e-0733910412IPR016024
Domain-

ZYG11A CAND2 ARMC3 ATAD2 ULK4 MMS19 GCN1 HTT SYMPK

4.16e-0622210491.25.10.10
DomainHEAT

CAND2 MMS19 GCN1 HTT SYMPK

6.88e-06481045PF02985
DomainHEAT

CAND2 MMS19 GCN1 HTT SYMPK

1.76e-05581045IPR000357
DomainATPase_AAA_CS

PSMC2 PSMC3 ATAD2 ATAD2B

1.94e-05291044IPR003960
DomainARM-like

ZYG11A CAND2 ARMC3 ATAD2 ULK4 MMS19 GCN1 HTT SYMPK

2.00e-052701049IPR011989
DomainAnk_2

ANKRD37 ANKRD10 ANKRD30B ANKRD27 CLIP3 ASB16 DGKI ANKRD33B

2.70e-052151048PF12796
DomainAAA

PSMC2 PSMC3 ATAD2 ATAD2B

3.70e-05341044PS00674
DomainAnk

ANKRD37 ANKRD10 ANKRD30B ANKRD27 CLIP3 ASB16 DGKI ANKRD33B

4.11e-052281048PF00023
DomainHEAT_REPEAT

CAND2 ULK4 MMS19 GCN1 HTT

4.41e-05701045PS50077
Domain-

ANKRD37 ANKRD10 ANKRD30B ANKRD27 CLIP3 ASB16 DGKI ANKRD33B

7.42e-0524810481.25.40.20
DomainANK

ANKRD37 ANKRD10 ANKRD30B ANKRD27 CLIP3 ASB16 DGKI ANKRD33B

8.07e-052511048SM00248
DomainANK_REPEAT

ANKRD37 ANKRD10 ANKRD30B ANKRD27 CLIP3 ASB16 DGKI ANKRD33B

8.53e-052531048PS50088
DomainAnkyrin_rpt-contain_dom

ANKRD37 ANKRD10 ANKRD30B ANKRD27 CLIP3 ASB16 DGKI ANKRD33B

8.77e-052541048IPR020683
DomainANK_REP_REGION

ANKRD37 ANKRD10 ANKRD30B ANKRD27 CLIP3 ASB16 DGKI ANKRD33B

8.77e-052541048PS50297
DomainTalin-1

TLNRD1 TLN1

9.18e-0531042IPR015710
DomainAnkyrin_rpt

ANKRD37 ANKRD10 ANKRD30B ANKRD27 CLIP3 ASB16 DGKI ANKRD33B

1.09e-042621048IPR002110
DomainAAA

PSMC2 PSMC3 ATAD2 ATAD2B

2.00e-04521044PF00004
DomainATPase_AAA_core

PSMC2 PSMC3 ATAD2 ATAD2B

2.32e-04541044IPR003959
Domain26S_Psome_P45

PSMC2 PSMC3

4.54e-0461042IPR005937
DomainBROMODOMAIN_1

ATAD2 ATAD2B PHIP

1.14e-03371043PS00633
DomainBromodomain

ATAD2 ATAD2B PHIP

1.23e-03381043PF00439
DomainAAA

PSMC2 PSMC3 ATAD2 ATAD2B ABCD2

1.27e-031441045SM00382
DomainAAA+_ATPase

PSMC2 PSMC3 ATAD2 ATAD2B ABCD2

1.27e-031441045IPR003593
DomainDAGK_acc

DGKG DGKI

1.34e-03101042PF00609
DomainDiacylglycerol_kin_accessory

DGKG DGKI

1.34e-03101042IPR000756
DomainDAGKa

DGKG DGKI

1.34e-03101042SM00045
DomainBROMODOMAIN_2

ATAD2 ATAD2B PHIP

1.53e-03411043PS50014
DomainBromodomain

ATAD2 ATAD2B PHIP

1.64e-03421043IPR001487
DomainBROMO

ATAD2 ATAD2B PHIP

1.64e-03421043SM00297
Domain-

ATAD2 ATAD2B PHIP

1.64e-034210431.20.920.10
DomainDAGKc

DGKG DGKI

2.68e-03141042SM00046
DomainDiacylglycerol_kinase_cat_dom

DGKG DGKI

3.08e-03151042IPR001206
DomainDAGK

DGKG DGKI

3.08e-03151042PS50146
DomainDAGK_cat

DGKG DGKI

3.08e-03151042PF00781
DomainATPase_P-typ_TM_dom

ATP2A2 ATP2B1

3.50e-03161042IPR023298
Domain-

ATP2A2 ATP2B1

3.50e-031610421.20.1110.10
DomainC1_1

RASGRP4 DGKG DGKI

3.95e-03571043PF00130
DomainATPase_P-typ_cation-transptr_C

ATP2A2 ATP2B1

3.95e-03171042IPR006068
DomainCation_ATPase_C

ATP2A2 ATP2B1

3.95e-03171042PF00689
DomainNAD/diacylglycerol_kinase

DGKG DGKI

3.95e-03171042IPR016064
DomainPP2C

TAB1 PPM1N

3.95e-03171042IPR015655
DomainCation_ATPase_N

ATP2A2 ATP2B1

4.43e-03181042PF00690
DomainCation_ATPase_N

ATP2A2 ATP2B1

4.43e-03181042SM00831
DomainPP2C

TAB1 PPM1N

4.94e-03191042PF00481
DomainATPase_P-typ_cation-transptr_N

ATP2A2 ATP2B1

4.94e-03191042IPR004014
DomainZF_DAG_PE_1

RASGRP4 DGKG DGKI

5.46e-03641043PS00479
DomainZF_DAG_PE_2

RASGRP4 DGKG DGKI

5.46e-03641043PS50081
DomainPP2Cc

TAB1 PPM1N

5.47e-03201042SM00332
Domain-

TAB1 PPM1N

5.47e-032010423.60.40.10
DomainPPM-type_phosphatase_dom

TAB1 PPM1N

5.47e-03201042IPR001932
DomainPPM_2

TAB1 PPM1N

5.47e-03201042PS51746
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

PRPF31 PLEKHG4 UBR4 RPP30 PSMC2 PSMC3 SHMT2 MCCC1 DCK ATAD2 ANKRD27 WDR59 NUP205 CS SUGP2 CTR9 TLN1 H1-5 DIAPH1 MMS19 ATP2A2 GCN1 MVP ATP2B1 PHIP PCK2

3.45e-1413531062629467282
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

CUL4B UBR4 PSMC2 PSMC3 ATAD2 NUP205 SUGP2 TLN1 ATAD2B ATP2A2 GCN1 MVP PHIP SYMPK

1.27e-086531061422586326
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

CUL4B IFT172 UBR4 PSMC2 PSMC3 NUP205 SUGP2 CTR9 TLN1 DIAPH1 ATP2A2 GCN1 SYMPK

7.89e-086381061333239621
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

CAND2 ADAM15 UBR4 PSMC2 PSMC3 PLXNB2 NCDN NUP205 TLN1 MMS19 ATP2A2 GCN1 TBL2 PCK2 SYMPK

1.81e-079421061531073040
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

CAND2 SYNE1 UBR4 PSMC2 PSMC3 SHMT2 PLXNB2 NUP205 CS ATP2A2 GCN1 ATP2B1

1.93e-075731061228330616
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

CUL4B UBR4 RPP30 PSMC2 PSMC3 SHMT2 DCK NCDN NUP205 CS CTR9 TLN1 H1-5 DIAPH1 MMS19 GCN1 MVP HTT

4.06e-0714551061822863883
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

PRPF31 UBR4 PSMC2 PSMC3 SHMT2 MCCC1 DCK ANKRD27 NUP205 CS CTR9 H1-5 DIAPH1 ATP2A2 GCN1 PHIP PCK2

5.00e-0713181061730463901
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

OMA1 PRPF31 PSMC3 CTR9 TLN1 ATP2A2 GCN1 MVP ATP2B1 PCK2

7.03e-074221061027342126
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

CAND2 IFT172 DUSP1 UBR4 PSMC2 PSMC3 SHMT2 NUP205 CTR9 H1-5 TAB1 GCN1 ATP2B1 TBL2

1.61e-069741061428675297
Pubmed

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.

SYNE1 PSMC2 PSMC3 SHMT2 NUP205 CS CTR9 ATP2A2 GCN1 ATP2B1

1.62e-064631061034901782
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

PRPF31 PDGFRA RPP30 PSMC2 PSMC3 SHMT2 MCCC1 ATAD2 NUP205 SUGP2 CTR9 ATP2A2 CBX2 SYMPK

1.93e-069891061436424410
Pubmed

POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.

PRPF31 KIF27 RPP30 PSMC2 PSMC3 H1-5 TAB1 MVP

2.25e-06277106830745168
Pubmed

Interactome of the Autoimmune Risk Protein ANKRD55.

PSMC3 NUP205 CS TLN1 MMS19 ATP2A2 GCN1

2.55e-06197106731620119
Pubmed

Defining the membrane proteome of NK cells.

PDGFRA ACOX1 UBR4 PSMC2 PSMC3 APOE RETSAT ANKRD27 NCDN NUP205 SERPINB9 MMS19 GCN1 MVP ATP2B1

2.65e-0611681061519946888
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

CUL4B PSMC2 PSMC3 SHMT2 TLN1 ATP2A2

5.51e-06144106635681168
Pubmed

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

CUL4B SYNE1 PSMC2 PSMC3 SHMT2 DGKG CS TLN1 H1-5 ATP2A2 GCN1 MVP

6.40e-068031061236517590
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

PRPF31 KIF27 SYNE1 UBR4 PSMC3 SHMT2 ATAD2 NUP205 CS CTR9 TLN1 DIAPH1 ATP2A2 GCN1 ATP2B1 PHIP

6.61e-0614251061630948266
Pubmed

Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.

CUL4B KIF27 UBR4 TLN1 DIAPH1 GCN1 PCK2

8.12e-06235106728378594
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

CUL4B PSMC2 SHMT2 MCCC1 NCDN CTR9 DIAPH1 MMS19 TBL2 SYMPK

8.64e-065601061035241646
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

CUL4B CAND2 PSMC2 MMS19 TAB1 TBL2

8.72e-06156106622952844
Pubmed

Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease.

BCHE APOE

9.20e-062106218334913
Pubmed

Butyrylcholinesterase K and Apolipoprotein E-ɛ4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired Subjects.

BCHE APOE

9.20e-062106227567841
Pubmed

Influence of genetic polymorphisms in the apolipoprotein (APOE) and the butyrylcholinesterase (BCHE) gene on stress markers in older adults: a 3-year study.

BCHE APOE

9.20e-062106217996334
Pubmed

Synergy between the alteration in the N-terminal region of butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease.

BCHE APOE

9.20e-062106230914707
Pubmed

Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism.

BCHE APOE

9.20e-062106216973370
Pubmed

Association of Butyrylcholinesterase-K Allele and Apolipoprotein E ɛ4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer's Disease.

BCHE APOE

9.20e-062106226757188
Pubmed

Identification of Neurochondrin as a new interaction partner of the FH3 domain of the Diaphanous-related formin Dia1.

NCDN DIAPH1

9.20e-062106218572016
Pubmed

Lack of mitogen-activated protein kinase phosphatase-1 protects ApoE-null mice against atherosclerosis.

DUSP1 APOE

9.20e-062106220093631
Pubmed

The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women.

BCHE APOE

9.20e-062106211125748
Pubmed

Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo.

BCHE APOE

9.20e-062106220538374
Pubmed

Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains.

BCHE APOE

9.20e-062106211849755
Pubmed

The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase.

BCHE APOE

9.20e-062106219713000
Pubmed

Using meta-analysis to explain the diversity of results in genetic studies of late-onset Alzheimer's disease and to identify high-risk subgroups.

BCHE APOE

9.20e-062106211738493
Pubmed

Collaborative effect of SERCA and PMCA in cytosolic calcium homeostasis in human platelets.

ATP2A2 ATP2B1

9.20e-062106216669348
Pubmed

Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis.

APOE BMPER

9.20e-062106222772758
Pubmed

BuChE K variant is decreased in Alzheimer's disease not in fronto-temporal dementia.

BCHE APOE

9.20e-062106220058037
Pubmed

Interaction between Apolipoprotein E and Butyrylcholinesterase Genes on Risk of Alzheimer's Disease in a Prospective Cohort Study.

BCHE APOE

9.20e-062106232250307
Pubmed

Influence of Butyrylcholinesterase in Progression of Mild Cognitive Impairment to Alzheimer's Disease.

BCHE APOE

9.20e-062106229254094
Pubmed

BuChE-K and APOE epsilon4 allele frequencies in Lewy body dementias, and influence of genotype and hyperhomocysteinemia on cognitive decline.

BCHE APOE

9.20e-062106219006190
Pubmed

A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice.

PDGFRA HTT

9.20e-062106236044851
Pubmed

Butyrylcholinesterase K variant and the APOE-epsilon 4 allele work in synergy to increase the risk of coronary artery disease especially in diabetic patients.

BCHE APOE

9.20e-062106219685167
Pubmed

No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases.

BCHE APOE

9.20e-062106219481150
Pubmed

Butyrylcholinesterase K and apolipoprotein ε4 affect cortical thickness and neuropsychiatric symptoms in Alzheimer's disease.

BCHE APOE

9.20e-062106224479631
Pubmed

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers.

BCHE APOE

9.20e-062106238594621
Pubmed

Divergent JAM-C Expression Accelerates Monocyte-Derived Cell Exit from Atherosclerotic Plaques.

APOE JAM3

9.20e-062106227442505
Pubmed

Analysis of association between butyrylcholinesterase K variant and apolipoprotein E genotypes in Alzheimer's disease.

BCHE APOE

9.20e-062106215519745
Pubmed

Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease.

BCHE APOE

9.20e-062106220644562
Pubmed

A disintegrin and metalloproteinase 15 contributes to atherosclerosis by mediating endothelial barrier dysfunction via Src family kinase activity.

ADAM15 APOE

9.20e-062106222904271
Pubmed

Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome.

RTEL1 TERF1

9.20e-062106223959892
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

PRPF31 CAND2 UBR4 RPP30 PSMC2 PSMC3 SHMT2 NUP205 SUGP2 GCN1 PCK2

1.05e-057041061129955894
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

CUL4B SYNE1 ACOX1 UBR4 CS SERPINB9 TLN1 MYPN MMS19 TAB1 GCN1 MVP

1.05e-058441061225963833
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

UBR4 PSMC2 PSMC3 APOE RETSAT NUP205 TLN1 DIAPH1 ATP2A2 GCN1 PCK2

1.16e-057111061133022573
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

PRPF31 SYNE1 SHMT2 PLXNB2 NCDN NUP205 CS SUGP2 TLN1 ATP2A2 GCN1 ATP2B1 PHIP

1.47e-0510241061324711643
Pubmed

Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.

PSMC2 PSMC3 ATAD2 NUP205 MMS19 ATP2A2 GCN1

1.94e-05269106730442662
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

PDGFRA PSMC3 ATP2A2 PHIP CBX2

2.17e-05109106533554859
Pubmed

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.

EGLN2 TCN2 RPP30 APOE NCDN

2.37e-05111106521163940
Pubmed

Autoregulation of the 26S proteasome by in situ ubiquitination.

UBR4 PSMC2 PSMC3

2.57e-0519106324743594
Pubmed

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.

CUL4B PSMC2 PSMC3

2.57e-0519106317392787
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

UBR4 RPP30 SUGP2 CTR9 MMS19 GCN1 CBX2

2.63e-05282106723667531
Pubmed

Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models.

DUSP1 APOE

2.76e-053106215242861
Pubmed

Central region of talin has a unique fold that binds vinculin and actin.

TLNRD1 TLN1

2.76e-053106220610383
Pubmed

Cutting edge: JAM-C controls homeostatic chemokine secretion in lymph node fibroblastic reticular cells expressing thrombomodulin.

PDGFRA JAM3

2.76e-053106221685324
Pubmed

Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.

PDGFRA SHMT2

2.76e-053106230367038
Pubmed

Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects.

BCHE APOE

2.76e-053106211793025
Pubmed

Relation between butyrylcholinesterase K variant, paraoxonase 1 (PON1) Q and R and apolipoprotein E epsilon 4 genes in early-onset coronary artery disease.

BCHE APOE

2.76e-053106212074828
Pubmed

Mitogen-activated protein kinase phosphatase-1 deficiency decreases atherosclerosis in apolipoprotein E null mice by reducing monocyte chemoattractant protein-1 levels.

DUSP1 APOE

2.76e-053106220619710
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CAND2 UBR4 PSMC2 PSMC3 SHMT2 MCCC1 NUP205 TLN1 H1-5 MMS19 ATP2A2 GCN1 ATP2B1 TBL2 PCK2

3.16e-0514401061530833792
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

UBR4 RPP30 PSMC2 PSMC3 TLN1 MMS19 GCN1 ATP2B1

3.17e-05399106837536630
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ANKRD37 UBR4 PLXNB2 WDR59 TLNRD1 SUGP2 TLN1 ULK4 GCN1 ANKRD33B HTT CBX2 SYMPK

3.24e-0511051061335748872
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

SYNE1 UBR4 PSMC3 SHMT2 MCCC1 CS TLN1 H1-5 DIAPH1 ATP2A2 GCN1

3.69e-058071061130575818
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

RPP30 PSMC2 PSMC3 MMS19 ATP2A2 GCN1

4.78e-05211106617314511
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

PRPF31 CAND2 UBR4 PSMC2 PSMC3 SHMT2 TLN1 DIAPH1 MMS19 TAB1 ATP2A2 GCN1 SYMPK

4.84e-0511491061335446349
Pubmed

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.

PSMC2 NUP205 TLN1 H1-5 GCN1 MVP ATP2B1

4.99e-05312106737120454
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

CUL4B UBR4 PSMC2 PSMC3 SHMT2 DGKI MMS19 PCK2 CBX2 SYMPK

5.04e-056891061036543142
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

RASGRP4 PDGFRA WNT10B UBR4 SHMT2 MAU2 ATAD2 WDR59 NUP205 TLNRD1 CS CTR9 GCN1 HTT

5.17e-0513271061432694731
Pubmed

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.

FEZF1 FZD5 FOXD4

5.32e-0524106329992973
Pubmed

Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.

PSMC2 PSMC3 NUP205 ATP2B1

5.39e-0567106429357390
Pubmed

Model Predicts That MKP1 and TAB1 Regulate p38α Nuclear Pulse and Its Basal Activity through Positive and Negative Feedback Loops in Response to IL-1.

DUSP1 TAB1

5.50e-054106227314954
Pubmed

Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.

DGKI PHIP

5.50e-054106232492392
Pubmed

Improved prediction of early-onset coronary artery disease using APOE epsilon4, BChE-K, PPARgamma2 Pro12 and ENOS T-786C in a polygenic model.

BCHE APOE

5.50e-054106216298355
Pubmed

Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease.

PSMC2 PSMC3

5.50e-05410628500623
Pubmed

Association of the 19S proteasomal ATPases with the ATPase-binding domain of CIITA is essential for CIITA stability and MHC class II expression.

PSMC2 PSMC3

5.50e-054106220351748
Pubmed

Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.

APOE ATP2A2

5.50e-054106225110346
Pubmed

Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample.

BCHE APOE

5.50e-054106217503475
Pubmed

Common variations in 4p locus are related to male completed suicide.

EVC HTT

5.50e-054106219115052
Pubmed

The nongastric H+-K+-ATPases: molecular and functional properties.

ATP2A2 ATP2B1

5.50e-054106210362770
Pubmed

Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.

APOE MVP

5.50e-054106230996248
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CUL4B PRPF31 UBR4 MAU2 NUP205 BROX SUGP2 CTR9 H1-5 DIAPH1 MMS19 SYMPK

6.29e-0510141061232416067
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

UBR4 PSMC3 CTR9 TLN1 MMS19 GCN1 SYMPK

7.36e-05332106732786267
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

RPP30 PSMC3 MAU2 TERF1 ATRIP ATP2A2 ATP2B1 CBX2

7.71e-05453106829656893
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

CUL4B PSMC2 SHMT2 TLN1 H1-5 MMS19 ATP2A2 GCN1 ATP2B1 PCK2 HTT

7.84e-058781061137223481
Pubmed

Functional proteomics mapping of a human signaling pathway.

EGLN2 RARB UBR4 PSMC2 TERF1 ANKRD27 CTR9 POLI DIAPH1

8.46e-05591106915231748
Pubmed

Differential left-to-right atria gene expression ratio in human sinus rhythm and atrial fibrillation: Implications for arrhythmogenesis and thrombogenesis.

APOE ATP2A2

9.15e-055106227494721
Pubmed

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.

APOE BMPER

9.15e-055106224770881
Pubmed

Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study.

APOE DGKI

9.15e-055106224468470
Pubmed

Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly.

CUL4B PHIP

9.15e-055106234171797
Pubmed

RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.

PSMC3 MCCC1 NUP205 H1-5 DIAPH1 ATP2A2 GCN1

9.19e-05344106736282215
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

CAND2 DUSP1 UBR4 RPP30 PSMC2 PSMC3 SHMT2 NUP205 CTR9 MMS19 ATP2A2 GCN1 TBL2

1.19e-0412571061337317656
Pubmed

Susceptibility groups for Alzheimer's disease (OPTIMA cohort): integration of gene variants and biochemical factors.

BCHE APOE

1.37e-046106217116317
Pubmed

ASK1 negatively regulates the 26 S proteasome.

PSMC2 PSMC3

1.37e-046106220843792
InteractionTPTE interactions

CAND2 UBR4 NUP205 TLN1 ATP2A2 GCN1 ATP2B1 TBL2

3.00e-071291028int:TPTE
InteractionNPTN interactions

CAND2 PLEKHG4 APOE MMS19 ATP2A2 GCN1 ATP2B1 CNTN1 HTT SYMPK

1.48e-0627810210int:NPTN
InteractionUNC93B1 interactions

CAND2 UBR4 PSMC2 PSMC3 MCCC1 NUP205 MMS19 ATP2A2 GCN1 ATP2B1 TBL2

8.59e-0641710211int:UNC93B1
InteractionPSMD14 interactions

PRPF31 KIF27 UBR4 RPP30 PSMC2 PSMC3 NLRP9 CS H1-5 TAB1 MVP HTT

1.44e-0552710212int:PSMD14
InteractionSIRT7 interactions

CUL4B UBR4 PSMC2 PSMC3 ATAD2 NUP205 SUGP2 TLN1 ATAD2B ATP2A2 GCN1 MVP PHIP SYMPK

2.27e-0574410214int:SIRT7
InteractionP2RY6 interactions

CAND2 UBR4 PSMC2 PSMC3 H1-5 ATP2A2 GCN1 ATP2B1 TBL2 PCK2

2.58e-0538510210int:P2RY6
InteractionATP1A1 interactions

CUL4B OMA1 PSMC2 PSMC3 SHMT2 NCDN TLN1 MMS19 MAPK4 ATP2A2 ATP2B1 HTT

3.39e-0557510212int:ATP1A1
InteractionPMS2 interactions

PMS2P1 PSMC2 PSMC3 CTR9 MMS19

5.35e-05801025int:PMS2
InteractionDUSP2 interactions

UBR4 NUP205 MAPK4 GCN1 ATP2B1

5.68e-05811025int:DUSP2
InteractionNR2C2 interactions

CUL4B PRPF31 UBR4 PSMC2 PSMC3 SHMT2 MCCC1 DCK ANKRD27 NUP205 CS CTR9 H1-5 DIAPH1 TAB1 ATP2A2 GCN1 PHIP PCK2

7.02e-05140310219int:NR2C2
InteractionMAPK12 interactions

DUSP1 SHMT2 TERF1 TAB1 GCN1

7.57e-05861025int:MAPK12
InteractionLMBR1L interactions

CAND2 ADAM15 UBR4 PSMC2 PSMC3 PLXNB2 NCDN NUP205 TLN1 MMS19 ATP2A2 GCN1 TBL2 PCK2 SYMPK

8.08e-0594610215int:LMBR1L
GeneFamilyAnkyrin repeat domain containing

ANKRD37 ANKRD10 ANKRD30B ANKRD27 CLIP3 ASB16 DGKI ANKRD33B

2.70e-06242668403
GeneFamilyAAA ATPases

PSMC2 PSMC3 ATAD2 ATAD2B

4.15e-0553664413
GeneFamilyATPases Ca2+ transporting

ATP2A2 ATP2B1

4.65e-0496621209
GeneFamilyEF-hand domain containing|Diacylglycerol kinases

DGKG DGKI

5.80e-04106621178
GeneFamilyWD repeat domain containing

IFT172 WDR54 WDR59 PHIP TBL2

2.68e-03262665362
ToppCell343B-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ANKRD37 NUP205 FGFBP3 KIF19 TAB1 HTT

7.06e-061921076445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TCN2 SHMT2 PKD2L1 KIF19 DGKI JAM3

7.49e-0619410762dcc3b99dbedaf8a6916891c85091ddb79d7ee31
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PDGFRA SYNE1 DGKG CLIP3 KIF19 CNTN1

8.66e-061991076333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PDGFRA SYNE1 DGKG CLIP3 KIF19 CNTN1

8.66e-06199107619a97e27a4758e794ce7246d295e112b47931a48
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PDGFRA SYNE1 DGKG CLIP3 KIF19 CNTN1

8.66e-061991076e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
DrugHMDS

TCN2 IFT172 SYNE1 DCK

2.50e-06211064CID000013838
DiseaseColorectal Carcinoma

OMA1 RARB TCN2 SYNE1 JAKMIP2 NCDN MLH3 H1-5 ABCD2 PHIP CNTN1

2.92e-0570210111C0009402
Diseaseparental longevity

RARB PKD2L1 APOE PLXNB2 ANKRD27 CCDC171 ANKRD33B PHIP HTT

5.14e-054941019EFO_0007796
Diseasecold shock domain-containing protein C2 measurement

BCHE APOE

6.93e-0541012EFO_0802415
DiseaseRING finger protein 122 measurement

BCHE APOE

6.93e-0541012EFO_0803028
Diseasetranscobalamin-2 measurement

TCN2 SLC35E4

6.93e-0541012EFO_0802139
Diseasefatty acid measurement, linoleic acid measurement

KIF27 MAU2 APOE CCDC171

8.90e-05681014EFO_0005110, EFO_0006807
Diseaselow-density lipoprotein receptor measurement

BCHE APOE

1.15e-0451012EFO_0021937
Diseasepalmitoleoyl-linoleoyl-glycerol (16:1/18:2) [1] measurement

PKD2L1 MAU2

1.15e-0451012EFO_0800504
Diseasedermokine measurement

BCHE APOE

1.72e-0461012EFO_0802462
Diseasecarbohydrate intake measurement

RARB APOE CCDC171

2.16e-04341013EFO_0010811
Diseasesmall nuclear ribonucleoprotein F measurement

BCHE APOE

4.11e-0491012EFO_0008288
Diseaseepididymal-specific lipocalin-10 measurement

BCHE APOE

4.11e-0491012EFO_0801576
Diseasestromal interaction molecule 1 measurement

BCHE APOE

5.13e-04101012EFO_0802093
Diseasef-box/LRR-repeat protein 4 measurement

BCHE APOE

5.13e-04101012EFO_0802538
Diseasecytochrome p450 3a4 measurement

BCHE APOE

6.25e-04111012EFO_0020303
Diseasecup-to-disc ratio measurement

RARB PDGFRA ADAM15 DUSP1 MYPN CCDC171 SYMPK

7.05e-044301017EFO_0006939
Diseaseprotein CEI measurement

BCHE APOE

7.49e-04121012EFO_0801936
Diseasetumor protein p53-inducible protein 11 measurement

BCHE APOE

7.49e-04121012EFO_0802169
Diseaseintegral membrane protein 2B measurement

BCHE APOE

7.49e-04121012EFO_0802634
Diseaseinactive gamma-glutamyltranspeptidase 2 measurement

BCHE APOE

7.49e-04121012EFO_0801692
DiseaseRAC-beta serine/threonine-protein kinase measurement

BCHE APOE

8.83e-04131012EFO_0021989
DiseasetRNA (guanine-N(7)-)-methyltransferase measurement

BCHE APOE

8.83e-04131012EFO_0802162
Diseaseeosinophil percentage of leukocytes

RASGRP4 RARB KIF27 ADAM15 NUP205 POLI ANKRD33B MAST3 SYMPK

1.06e-037461019EFO_0007991
Diseasesleep measurement

KIF27 PSMC3 JAKMIP2 CTR9

1.21e-031351014EFO_0004870
Diseaseceramide measurement

PKD2L1 MAU2 APOE SLC35E4 CCDC171

1.31e-032351015EFO_0010222
Diseaseliver fat measurement, liver disease biomarker

APOE PCK2

1.35e-03161012EFO_0006845, EFO_0010821
DiseaseAbdominal Aortic Aneurysm

OMA1 OR1J1 APOE

1.66e-03681013EFO_0004214
Diseaseandrostenedione measurement, estrone measurement

ARMC3 BMPER

1.71e-03181012EFO_0007970, EFO_0007972
Diseasegait measurement

RARB ADAM15 MAST3 HTT

1.79e-031501014EFO_0007680
Diseasehydrocephalus (implicated_via_orthology)

KIF27 ULK4

1.91e-03191012DOID:10908 (implicated_via_orthology)
Diseasesodium-coupled monocarboxylate transporter 1 measurement

BCHE APOE

1.91e-03191012EFO_0802076
Diseaseage at first sexual intercourse measurement

OMA1 RARB ARMC3 TERF1 NUP205 FEZF1

2.07e-033831016EFO_0009749
Diseaseasthma, endometriosis

RARB PLXNB2 SYMPK

2.12e-03741013EFO_0001065, MONDO_0004979
DiseaseHbA1c measurement

ADAM15 HKDC1 PKD2L1 APOE ATRIP ASB16 ATAD2B MYPN

2.25e-036751018EFO_0004541
Diseasesaturated fatty acids to total fatty acids percentage

PKD2L1 APOE

2.33e-03211012EFO_0022305
Diseasecomplex trait

IFT172 MAU2 APOE SUGP2 TBL2

2.44e-032711015EFO_0010578
Diseasemonounsaturated fatty acids; 16:1, 18:1 measurement

PKD2L1 MAU2 APOE

2.46e-03781013EFO_0022187
Diseaseserum alanine aminotransferase measurement

HKDC1 PKD2L1 MAU2 APOE PLXNB2 DIAPH1 TBL2 MAST3 HTT

2.99e-038691019EFO_0004735
Diseasetotal brain volume change measurement, age at assessment

APOE MAPK4

3.31e-03251012EFO_0008007, EFO_0021504

Protein segments in the cluster

PeptideGeneStartEntry
LTAREACAKGLVSQV

CDY1

451

Q9Y6F8
EARNRTLNLAKLTGC

BCHE

266

P06276
AALLVTFLAGCQAKV

APOE

6

P02649
AARLVEGTSAKIQCL

ANKRD30B

306

Q9BXX2
KAARSGSLECISALV

ANKRD10

131

Q9NXR5
RSSAAKRAACLVAAA

ABCD2

16

Q9UBJ2
SNCSRRALEKALLDG

ADAM15

391

Q13444
ANRLKILGQSCASLF

CCDC171

811

Q6TFL3
CAKLLLEAGATVNLA

ASB16

191

Q96NS5
TGKTLVARALANECS

ATAD2

471

Q6PL18
LLSSKRDGAIANAAT

ARMC3

406

Q5W041
ANRKAGCAVTSLLAS

DIAPH1

1221

O60610
NINTARAIATKCGIL

ATP2B1

711

P20020
TATLLRAACANNVGL

ANKRD33B

86

A6NCL7
AAKVGSLECLSLLVA

ANKRD37

71

Q7Z713
GLTIADQITLLKAAC

RARB

251

P10826
SRAALEALGSCLNNK

SHMT2

81

P34897
CIANSLKALIQSRRG

NUP205

141

Q92621
AVCGQASLIDLLVSK

ANKRD27

471

Q96NW4
TIAVRCLAKNLLGAE

PDGFRA

496

P16234
CLLAAARREKGAASN

FGFBP3

21

Q8TAT2
IQRLKSALCALRDGS

JAKMIP2

111

Q96AA8
KCLVLASLVALLGSA

JSRP1

126

Q96MG2
ALKLAARLAHACGSD

NCDN

281

Q9UBB6
NGLVLSAVDSRACRK

MAPK4

31

P31152
SAKLLQAAAGASARA

MMS19

371

Q96T76
GKTLVARALANECSQ

ATAD2B

446

Q9ULI0
SRGEANVLEKLACLS

KIF27

1091

Q86VH2
NSLLGKKCFALRIAS

PCK2

256

Q16822
FKGICALRALSNISL

PLXNB2

116

O15031
AKLRSGLAISSLGQC

MLH3

11

Q9UHC1
ALGCRIAELCASAQK

PPM1N

346

Q8N819
LRASAICSKLGLAFL

RASGRP4

526

Q8TDF6
RLNSAEAAAKALSTC

OR56B1

236

Q8NGI3
LGFLASTCADKRTIA

GCN1

1931

Q92616
GCLIGAVNLKSSNRT

JAM3

26

Q9BX67
LTLLLAFGKNAVRCA

PMS2P1

116

A4D2B8
LRKLLSRSGAVAHAC

OR1J1

301

Q8NGS3
ADASLSALRVSCKGS

FOXD4

316

Q12950
GNAALNSKLCDLLLS

ALAS2

481

P22557
ACKAIASRVRGAVAS

MVP

571

Q14764
RCSIKAIEAALGARQ

IFT172

881

Q9UG01
SLLALGNCINALSDK

KIF19

276

Q2TAC6
AGSVLSCKNAQLARD

FAM189B

111

P81408
TGLKSAGRRLAQCAS

DGKG

721

P49619
LLAQLVGRAAAASKA

FZD5

16

Q13467
VGEAARALSKACTIA

ACOX1

286

Q15067
GLSKIERANACNSVI

ATP2A2

461

P16615
VKALALSCVGAAVAL

HTT

711

P42858
VAASKERNGLSLAAL

H1-5

51

P16401
VLSRDCALAIKQRGA

BMPER

86

Q8N8U9
ASRLALKAQATNKCG

CBX2

271

Q14781
AKRDGTLALAAGALC

DUSP1

96

P28562
CQLLVDAGASLRKTD

DGKI

1011

O75912
AAARLLGTKNASCLV

CS

6

O75390
LGTKNASCLVLAARH

CS

11

O75390
SLEGKVSLNCRARAS

CNTN1

56

Q12860
FSRALELNSKCVGAL

CTR9

221

Q6PD62
KAAAKESLCQAALGL

MCCC1

501

Q96RQ3
LARDCLAKSGENLVT

MAST3

221

O60307
CLSRIRAQLASLNGK

DCK

101

P27707
AACKSDARLLLGRDA

EVC

6

P57679
AAALVTKGCQRLAAQ

EGLN2

96

Q96KS0
CQALQDLAAAKRSGA

ATRIP

431

Q8WXE1
ALHIAASSLCLGAAK

CLIP3

201

Q96DZ5
LKARSCSAARLASAQ

C1orf174

16

Q8IYL3
VRRAAAKCIAALISS

CAND2

351

O75155
CAGVASNKLLAKLVS

POLI

221

Q9UNA4
SSALLRDLNKACGNA

MAU2

541

Q9Y6X3
TLQSLACGKARVLAK

CUL4B

781

Q13620
DAKAAVSTNCRAALL

RPP30

216

P78346
ALQGALLCSSAILKR

RETSAT

576

Q6NUM9
ECLSSLGKALGNIAR

RTEL1

536

Q9NZ71
GKTLCARAVANRTDA

PSMC2

221

P35998
DKLLVSLGASRFCLQ

TAS2R60

56

P59551
KAIQDRLACAESTLG

SYNE1

2641

Q8NF91
ANVGTNRALLCKSTV

TAB1

181

Q15750
RSANLCAAALAAILT

HKDC1

381

Q2TB90
AACALLQGAIESVKA

PLEKHG4

346

Q58EX7
LNCALSLKGDLARDA

FEZF1

121

A0PJY2
QLLLCASLAAAAAGL

OCSTAMP

51

Q9BR26
LLAAKACADIRASSV

OMA1

401

Q96E52
AELGTACLKARVALL

TCN2

261

P20062
LLASDKCGEAIRSLQ

BROX

261

Q5VW32
AAALIACKTLRSLNL

NLRP9

906

Q7RTR0
LGAGRQSLLRTNKSC

PHIP

101

Q8WWQ0
NASGTFAIRLLKILC

SERPINB9

6

P50453
LLLCFGSQRAKAATA

PRSS27

11

Q9BQR3
SQCAKNLGTALAELR

TLN1

1021

Q9Y490
TGKTLLARACAAQTK

PSMC3

231

P17980
CRKSLALLGQTFSLA

SUGP2

476

Q8IX01
AARLVAAKCTLAARV

PRPF31

291

Q8WWY3
GLSRNLKFLTDACAL

TLNRD1

186

Q9H1K6
CQFLTRIAAGKTLDA

TERF1

126

P54274
LSSTLARCAKDILGF

PKD2L1

466

Q9P0L9
VACSGAAQVRIKILA

SYMPK

576

Q92797
NKIRAASAVGICSEL

MTHFD2L

101

Q9H903
TCQKNAASALLVGRK

WDR59

676

Q6PJI9
LLALLCASASGNAIQ

ZG16

6

O60844
ACTLAISAKGIADRL

UEVLD

196

Q8IX04
FLLAATCLRGLKSVQ

SLC35E4

191

Q6ICL7
ALCSRALSNEILGLK

WNT10B

21

O00744
VLAIGSSRCKANTLG

UBR4

1201

Q5T4S7
QLLSCALCGSKVLAA

UBR4

3321

Q5T4S7
ALCGSKVLAALAASS

UBR4

3326

Q5T4S7
LLLACALSAAAVGLK

TMEM271

16

A0A286YF58
TASACALNLTRQGLA

ZYG11A

401

Q6WRX3
LLAAALKSHSGNISC

TBL2

81

Q9Y4P3
TRKALCLAASGVGAL

nan

151

Q6ZTC4
GLNSVINSLASAICK

ULK4

691

Q96C45
CALDLASEVGKLLSA

WDR54

256

Q9H977
LSAKNEAGIVSCTAR

MYPN

1246

Q86TC9