Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	spectrin	SPTAN1 SPTBN2	3.07e-04	9	62	2	GO:0008091
GeneOntologyCellularComponent	cell-cell junction	OCEL1 AHI1 CDC42BPA SPTAN1 SPTBN2 CDH2 CDH4 BAIAP2L2	3.43e-04	591	62	8	GO:0005911
GeneOntologyCellularComponent	paranodal junction	SPTAN1 SPTBN2	4.68e-04	11	62	2	GO:0033010
GeneOntologyCellularComponent	fascia adherens	SPTAN1 CDH2	6.61e-04	13	62	2	GO:0005916
MousePheno	decreased birth body size	PDS5B SYNE1 PDS5A FOXI3 SLC10A7 HELLS	6.23e-05	232	42	6	MP:0009703
MousePheno	abnormal birth body size	PDS5B SYNE1 PDS5A FOXI3 SLC10A7 HELLS	7.02e-05	237	42	6	MP:0009701
Domain	Spectrin	SYNE1 SPTAN1 SPTBN2	5.07e-05	23	59	3	PF00435
Domain	Spectrin_repeat	SYNE1 SPTAN1 SPTBN2	1.03e-04	29	59	3	IPR002017
Domain	Spectrin/alpha-actinin	SYNE1 SPTAN1 SPTBN2	1.39e-04	32	59	3	IPR018159
Domain	SPEC	SYNE1 SPTAN1 SPTBN2	1.39e-04	32	59	3	SM00150
Domain	Cadherin_pro	CDH2 CDH4	2.04e-04	7	59	2	PF08758
Domain	Cadherin_pro_dom	CDH2 CDH4	2.71e-04	8	59	2	IPR014868
Domain	Cadherin_pro	CDH2 CDH4	2.71e-04	8	59	2	SM01055
Domain	C1_1	CDC42BPA MYO9B DGKH	7.76e-04	57	59	3	PF00130
Domain	ZF_DAG_PE_1	CDC42BPA MYO9B DGKH	1.09e-03	64	59	3	PS00479
Domain	ZF_DAG_PE_2	CDC42BPA MYO9B DGKH	1.09e-03	64	59	3	PS50081
Domain	C1	CDC42BPA MYO9B DGKH	1.14e-03	65	59	3	SM00109
Domain	PE/DAG-bd	CDC42BPA MYO9B DGKH	1.19e-03	66	59	3	IPR002219
Domain	Actinin_actin-bd_CS	SYNE1 SPTBN2	2.38e-03	23	59	2	IPR001589
Domain	G_patch	SUGP1 PINX1	2.38e-03	23	59	2	SM00443
Domain	G_patch_dom	SUGP1 PINX1	2.38e-03	23	59	2	IPR000467
Domain	G_PATCH	SUGP1 PINX1	2.38e-03	23	59	2	PS50174
Domain	G-patch	SUGP1 PINX1	2.38e-03	23	59	2	PF01585
Domain	ACTININ_2	SYNE1 SPTBN2	2.38e-03	23	59	2	PS00020
Domain	ACTININ_1	SYNE1 SPTBN2	2.38e-03	23	59	2	PS00019
Domain	Cadherin_cytoplasmic-dom	CDH2 CDH4	2.81e-03	25	59	2	IPR000233
Domain	Cadherin_C	CDH2 CDH4	2.81e-03	25	59	2	PF01049
Domain	Catenin_binding_dom	CDH2 CDH4	3.77e-03	29	59	2	IPR027397
Domain	-	CDH2 CDH4	3.77e-03	29	59	2	4.10.900.10
Pathway	WP_COHESIN_COMPLEX_CORNELIA_DE_LANGE_SYNDROME	PDS5B PPP2R5D PDS5A	1.70e-04	34	45	3	M42555
Pathway	KEGG_MEDICUS_REFERENCE_ESTABLISHMENT_OF_COHESION	PDS5B PDS5A	2.07e-04	7	45	2	M47869
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	PDS5B PDS5A	4.41e-04	10	45	2	M27178
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTAN1 SPTBN2	4.41e-04	10	45	2	MM15112
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	PDS5B PDS5A	4.41e-04	10	45	2	MM14892
Pathway	REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION	PDS5B PDS5A	5.38e-04	11	45	2	M27177
Pathway	REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION	PDS5B PDS5A	5.38e-04	11	45	2	MM14891
Pathway	REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS	PDS5B PDS5A	7.60e-04	13	45	2	M27661
Pathway	REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS	PDS5B PDS5A	7.60e-04	13	45	2	MM15363
Pubmed	Agrin has a pathological role in the progression of oral cancer.	SLC12A4 SYNE1 SPTAN1 SYCP1 SUGP1 PYGM	1.44e-06	197	62	6	29872149
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PDS5B REXO4 DNAJC13 CDC42BPA SYNE1 SPTAN1 SPTBN2 SUGP1 PDS5A TSG101 CPSF2	2.99e-06	1082	62	11	38697112
Pubmed	Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue.	CDH2 CDH4	3.13e-06	2	62	2	8247017
Pubmed	PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.	PDS5B PDS5A	3.13e-06	2	62	2	35986423
Pubmed	PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.	PDS5B PDS5A	3.13e-06	2	62	2	31757807
Pubmed	Characterization of a new beta-spectrin gene which is predominantly expressed in brain.	SPTAN1 SPTBN2	3.13e-06	2	62	2	9675416
Pubmed	N-Acetylglucosaminyltransferase V triggers overexpression of MT1-MMP and reinforces the invasive/metastatic potential of cancer cells.	MGAT5 MMP14	3.13e-06	2	62	2	23357422
Pubmed	PDS5A and PDS5B in Cohesin Function and Human Disease.	PDS5B PDS5A	3.13e-06	2	62	2	34070827
Pubmed	Functional cis-heterodimers of N- and R-cadherins.	CDH2 CDH4	3.13e-06	2	62	2	10662782
Pubmed	Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.	OR4A47 SPTAN1 TIMELESS CDH4	3.61e-06	58	62	4	24144296
Pubmed	Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres.	PDS5B PDS5A	9.37e-06	3	62	2	24141881
Pubmed	Evaluating Serum Levels of Pentraxin-3, von Willebrand Factor and C-X-C Motif Chemokine Ligand 13 as Inflammatory Markers of Unstable Angina Pectoris.	VWF CXCL13	9.37e-06	3	62	2	31066256
Pubmed	Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.	PDS5B PDS5A	9.37e-06	3	62	2	28343969
Pubmed	Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas.	CDH2 CDH4	9.37e-06	3	62	2	1406710
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MRPL17 MRPS7 DNAJC13 PPP2R5D CDC42BPA SYNE1 SPTAN1 SPTBN2 TTC13 EMC2 BCS1L HELLS	1.06e-05	1487	62	12	33957083
Pubmed	Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity.	CDH2 CDH4	1.87e-05	4	62	2	16461340
Pubmed	Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.	PDS5B PDS5A	1.87e-05	4	62	2	29217591
Pubmed	N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways.	MGAT5 CDH2	1.87e-05	4	62	2	14561752
Pubmed	Developmental defects in mouse embryos lacking N-cadherin.	CDH2 CDH4	1.87e-05	4	62	2	9015265
Pubmed	PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.	PDS5B PDS5A	1.87e-05	4	62	2	32285610
Pubmed	Calcium-dependent adhesion is necessary for the maintenance of prosomeres.	CDH2 CDH4	3.12e-05	5	62	2	11319859
Pubmed	Expression of classical cadherins in thyroid development: maintenance of an epithelial phenotype throughout organogenesis.	CDH2 CDH4	3.12e-05	5	62	2	12865344
Pubmed	Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene.	CDH2 CDH4	3.12e-05	5	62	2	8270638
Pubmed	STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion.	STAG3L1 STAG3L2	3.12e-05	5	62	2	10698974
Pubmed	Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.	PDS5B PDS5A	4.67e-05	6	62	2	15837422
Pubmed	Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion.	CDH2 CDH4	4.67e-05	6	62	2	8612964
Pubmed	Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation.	VWF MMP14	4.67e-05	6	62	2	15572153
Pubmed	ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors.	SPTAN1 SPTBN2	4.67e-05	6	62	2	37069398
Pubmed	In vivo assembly of the axon initial segment in motor neurons.	SPTAN1 SPTBN2	4.67e-05	6	62	2	23728480
Pubmed	Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear.	SPTAN1 CDH2	4.67e-05	6	62	2	35602553
Pubmed	Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton.	SPTAN1 SPTBN2	4.67e-05	6	62	2	16687515
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	PDS5B PPP2R5D SUGP1 PDS5A TIMELESS TSG101 BCS1L	6.18e-05	560	62	7	35241646
Pubmed	Genetic dissection of cadherin function during nephrogenesis.	CDH2 CDH4	6.53e-05	7	62	2	11839813
Pubmed	Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.	PDS5B PDS5A	6.53e-05	7	62	2	15855230
Pubmed	Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.	PDS5B PDS5A	6.53e-05	7	62	2	19412548
Pubmed	Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.	PDS5B PDS5A	8.69e-05	8	62	2	29867216
Pubmed	Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions.	PDS5B PDS5A	8.69e-05	8	62	2	21699228
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	DNAJC13 PPP2R5D CDC42BPA SLC12A4 SPTAN1 SPTBN2 PINX1 CPSF2 HELLS	9.64e-05	1049	62	9	27880917
Pubmed	Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.	PDS5B PDS5A	1.12e-04	9	62	2	17349791
Pubmed	Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.	PDS5B PDS5A	1.12e-04	9	62	2	16682347
Pubmed	Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.	PDS5B PDS5A	1.12e-04	9	62	2	17112726
Pubmed	Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.	PDS5B PDS5A	1.39e-04	10	62	2	22751501
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	SPTAN1 SPTBN2	1.39e-04	10	62	2	22159418
Pubmed	Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.	CDH2 CDH4	1.39e-04	10	62	2	2059658
Pubmed	Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.	PDS5B PDS5A	1.39e-04	10	62	2	23242214
Pubmed	Cadherin 2/4 signaling via PTP1B and catenins is crucial for nucleokinesis during radial neuronal migration in the neocortex.	CDH2 CDH4	1.39e-04	10	62	2	27151949
Pubmed	Sororin mediates sister chromatid cohesion by antagonizing Wapl.	PDS5B PDS5A	1.39e-04	10	62	2	21111234
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	SPTAN1 SPTBN2	1.70e-04	11	62	2	17607528
Pubmed	Wapl controls the dynamic association of cohesin with chromatin.	PDS5B PDS5A	1.70e-04	11	62	2	17113138
Pubmed	Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain.	CDH2 CDH4	1.70e-04	11	62	2	9367432
Pubmed	Mouse R-cadherin: expression during the organogenesis of pancreas and gastrointestinal tract.	CDH2 CDH4	1.70e-04	11	62	2	7493641
Pubmed	APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.	PDS5B PDS5A	1.70e-04	11	62	2	22293751
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PDS5B MRPS7 PPP2R5D SYNE1 SYCP1 PDS5A PYGM TIMELESS TSG101	1.99e-04	1155	62	9	20360068
Pubmed	Human transcription factor protein interaction networks.	MRPL17 MRPS7 YEATS2 REXO4 CDC42BPA SPTAN1 SUGP1 PDS5A CPSF2 HELLS	2.04e-04	1429	62	10	35140242
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTAN1 SPTBN2	2.41e-04	13	62	2	18796539
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	PDS5B YEATS2 REXO4 SUGP1 PINX1 PDS5A CWC25 HELLS	2.84e-04	954	62	8	36373674
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	PDS5B CDC42BPA SLC12A4 SYNE1 SFXN2 CWC25 CDH2	2.88e-04	719	62	7	35337019
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DNAJC13 PPP2R5D SYNE1 SPTAN1 SPTBN2 ZBTB22 CPSF2 CDH2	3.02e-04	963	62	8	28671696
Pubmed	Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.	SPTBN2 CDH2	3.23e-04	15	62	2	30562487
Pubmed	Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance.	CDH2 CDH4	3.23e-04	15	62	2	18507827
Pubmed	Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin.	PDS5B PDS5A	3.23e-04	15	62	2	23901111
Pubmed	Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse.	CDH2 CDH4	3.23e-04	15	62	2	33833667
Pubmed	No evidence of involvement of E-cadherin in cell fate specification or the segregation of Epi and PrE in mouse blastocysts.	CDH2 CDH4	3.23e-04	15	62	2	30735538
Pubmed	Cadherin expression in the developing mouse olfactory system.	CDH2 CDH4	3.69e-04	16	62	2	17278136
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	PDS5B MRPS7 REXO4 DNAJC13 MYO9B SCAPER PINX1	3.98e-04	759	62	7	35915203
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	CDC42BPA SPTAN1 OTUD7A PYGM	4.31e-04	197	62	4	36604605
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTAN1 SPTBN2	4.70e-04	18	62	2	12119179
Pubmed	Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.	VWF CDH2	4.70e-04	18	62	2	21810271
Pubmed	E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.	CDH2 CDH4	5.82e-04	20	62	2	7806582
Pubmed	Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons.	CDH2 CDH4	6.42e-04	21	62	2	25168025
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	PDS5B YEATS2 SUGP1 PDS5A	6.74e-04	222	62	4	37071664
Pubmed	Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.	MRPS7 DNAJC13 SLC12A4 TSG101	7.45e-04	228	62	4	30471916
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PDS5B REXO4 PINX1 PDS5A TIMELESS HELLS	7.47e-04	608	62	6	36089195
Pubmed	Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.	SPTAN1 SPTBN2 PYGM CDH2	8.08e-04	233	62	4	29518331
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	SPTAN1 SPTBN2	9.14e-04	25	62	2	30309841
Pubmed	Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity.	TSG101 CDH2	9.14e-04	25	62	2	33795534
Pubmed	Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes.	OTUD7A TSG101	9.89e-04	26	62	2	16280085
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	YEATS2 SUGP1 PDS5A CCDC102A HELLS	1.18e-03	444	62	5	34795231
Pubmed	Motor neuron position and topographic order imposed by β- and γ-catenin activities.	CDH2 CDH4	1.23e-03	29	62	2	22036570
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	PDS5B YEATS2 MYO9B SPTAN1 SCAPER TSG101 CPSF2	1.25e-03	922	62	7	27609421
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	OCEL1 REXO4 AHI1 SLC12A4 SPTBN2 PINX1 HELLS	1.27e-03	925	62	7	28986522
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	MGAT5 SCAPER TIMELESS TSG101 TTC13 CPSF2 EMC2 CDH2	1.28e-03	1201	62	8	35696571
Pubmed	Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth.	MMP14 CDH2	1.32e-03	30	62	2	22171010
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	PDS5B PPP2R5D PDS5A TIMELESS TTC13 EMC2 HELLS	1.41e-03	942	62	7	31073040
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	PDS5B SPTAN1 PDS5A HELLS	1.43e-03	272	62	4	31010829
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	CDC42BPA SPTAN1 SPTBN2 CPSF2	1.47e-03	274	62	4	34244482
Pubmed	The protein interaction landscape of the human CMGC kinase group.	OCEL1 SPTAN1 C16orf78 SFXN2 ZNF223 CPSF2	1.48e-03	695	62	6	23602568
Pubmed	The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.	SPTAN1 SPTBN2	1.50e-03	32	62	2	23704327
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	DNAJC13 AHI1 CDC42BPA	1.57e-03	128	62	3	30995482
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	MRPL17 MRPS7 SCAPER PDS5A SHCBP1L CPSF2 HELLS	1.67e-03	971	62	7	33306668
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	MRPL17 MRPS7 CDC42BPA SPTAN1 SPTBN2 CPSF2	1.69e-03	713	62	6	29802200
Pubmed	A human MAP kinase interactome.	VWF CDC42BPA SYNE1 SPTAN1 SPTBN2	1.76e-03	486	62	5	20936779
Cytoband	19p13.11	OCEL1 NWD1 SUGP1	1.36e-04	73	62	3	19p13.11
GeneFamily	CD molecules\|Type I classical cadherins	CDH2 CDH4	5.50e-05	5	43	2	1185
GeneFamily	EF-hand domain containing\|Spectrins	SPTAN1 SPTBN2	1.15e-04	7	43	2	1113
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	SUGP1 PINX1	1.24e-03	22	43	2	579
Coexpression	GSE20715_WT_VS_TLR4_KO_LUNG_DN	MRPS7 VWF SLC12A4 SYNE1 SPTBN2 MMP14	6.97e-06	199	61	6	M4350
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 DGKH FAM167B	8.70e-06	200	62	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 DGKH FAM167B	8.70e-06	200	62	5	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZBTB22 OTUD7A CDH2 CDH4	6.97e-05	158	62	4	7f5426585d0d299d2b48e5fcb349950feffdef33
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO9B SUGP1 TIMELESS SHCBP1L	8.24e-05	165	62	4	7c771f22b58989572c939ed127e637ec28dc0dca
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RUNDC3A NWD1 GUCA1B SFXN2	8.64e-05	167	62	4	b94e8ee8c3fcebedd8fcd719eadddc04c7513c50
ToppCell	Neuroendocrine-neuroendo-1\|World / Class top	RUNDC3A VWF CXCL13 CDH4	1.15e-04	180	62	4	50fdd182a083380899b5943cb5f55ffd77e2a7d4
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	YEATS2 ZBTB22 SUGP1 RAB40C	1.15e-04	180	62	4	551b8de8d933d11bcd3897aeb2fd033355f958e2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PPP2R5D SYNE1 TTC13 CCDC102A	1.18e-04	181	62	4	5cecbafc29cc95896e6ccb2c74d9237b9aaece69
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	YEATS2 ZBTB22 SUGP1 RAB40C	1.23e-04	183	62	4	310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	YEATS2 ZBTB22 SUGP1 RAB40C	1.23e-04	183	62	4	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PDS5B OTUD7A TIMELESS HELLS	1.42e-04	190	62	4	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	YEATS2 MGAT5 SYNE1 FAM167B	1.66e-04	198	62	4	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	MRPL17 MRPS7 CXCL13 FAM167B	1.69e-04	199	62	4	0637e1ae6db9681d86cc21a5fb274dc562604f35
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Vein\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.69e-04	199	62	4	cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	MRPL17 MRPS7 CXCL13 FAM167B	1.69e-04	199	62	4	076cf7f0994fc6f03b11bc7b51be6dcd9ee41985
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Tumor\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	MRPL17 MRPS7 CXCL13 FAM167B	1.69e-04	199	62	4	e1be40821330fd273ef54e39d730b31ce0a8f94e
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	89a6da2bdedc6b1ad0675c8753bf2b763a99af6a
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	b70b7adb7c187e6253c7f0bb4c1f09c85ef7142c
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	58a7ece7dfdf6c46f2a50cbcb580574dec14c748
ToppCell	LPS_IL1RA_TNF-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	LPS_anti-TNF-Endothelial-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	60d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	3585484c7e24e941708bee471ca607d8ccee74e6
ToppCell	LPS_only-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	81e76508c9050d533853d5fd2f3097b27613d836
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	4bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	VWF SPTAN1 PINX1 FAM167B	1.73e-04	200	62	4	f15fffefe372005c33e31845982e2d2714ac26af
Drug	1,7-octadiene	VWF SYNE1 BCS1L	7.31e-08	4	61	3	CID000019460
Drug	Cholecalciferol [67-97-0]; Down 200; 10.4uM; PC3; HT_HG-U133A	PDS5B SYNE1 CIDEC SPTBN2 SCAPER SUGP1 MMP14	8.65e-07	194	61	7	6656_DN
Drug	SC-560; Down 200; 10uM; PC3; HT_HG-U133A	MYO9B SPTAN1 SPTBN2 SCAPER TIMELESS MMP14	1.50e-05	198	61	6	6865_DN
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A	CDC42BPA MYO9B SPTAN1 SUGP1 RAB40C TIMELESS	1.54e-05	199	61	6	3860_DN
Disease	intracranial aneurysm (is_marker_for)	VWF MMP14	3.76e-04	14	61	2	DOID:10941 (is_marker_for)
Disease	platelet component distribution width	PDS5B AHI1 VWF MYO9B SYNE1 SUGP1 PDS5A	9.18e-04	755	61	7	EFO_0007984
Disease	response to clopidogrel, cardiovascular event measurement	CDC42BPA SLC10A7	1.03e-03	23	61	2	EFO_0006919, GO_1903493
Disease	Retinitis Pigmentosa	AHI1 GUCA1B SCAPER	1.32e-03	104	61	3	C0035334
Disease	azoospermia (implicated_via_orthology)	CDC42BPA SCAPER	1.43e-03	27	61	2	DOID:14227 (implicated_via_orthology)
Disease	cranial vault morphology measurement	EMC2 CDH2 WARS2	2.04e-03	121	61	3	EFO_0009278

Protein segments in the cluster

Peptide	Gene	Start	Entry
LERKRQEMMENAKWR	CWC25	341	Q9NXE8
WMSDKLMRCFEDKRN	CPSF2	286	Q9P2I0
MIRIWKVEMREDSAI	AHI1	721	Q8N157
KWIRVERSREMQMID	BCS1L	111	Q9Y276
RKYMWKTAEDRRMSD	C16orf78	16	Q8WTQ4
RFRMKEREEMWQKIE	PPP2R5D	496	Q14738
AERMAIRQTWGKERM	B3GALT5	71	Q9Y2C3
KSIRMWERKVEIAEM	CCDC113	336	Q9H0I3
RRKMMNEMERKEWAF	CFAP91	266	Q7Z4T9
MWMVKSRQREELVAA	NWD1	1521	Q149M9
VAMLRGEMFVFKERW	MMP14	326	P50281
SRIVLMRHGMEKIWR	RAB40C	171	Q96S21
RTLDKRWRVRKEAMM	PDS5B	396	Q9NTI5
RWRVRKEAMMGLAQI	PDS5B	401	Q9NTI5
RTLDKRWRVRKEAMM	PDS5A	406	Q29RF7
RWRVRKEAMMGLAQL	PDS5A	411	Q29RF7
VAARVWREFEMKRMD	OCEL1	211	Q9H607
WDLFRSKDNMRTRIM	SLC2A12	266	Q8TD20
MRLLERMRKDWFMVG	SLC10A7	1	Q0GE19
WLSMASREDLMKMVR	FOXI3	131	A8MTJ6
RKMLEKARMSWDRES	HELLS	46	Q9NRZ9
KHEEFRWMRLRIRRM	MGAT5	231	Q09328
CMSELWRMERKRDKN	BAIAP2L2	136	Q6UXY1
EMTSAMKKLWRRDLI	OR4A47	291	Q6IF82
MSMLAERRRKQKWAV	PINX1	1	Q96BK5
MMRTGAEREALKRRW	OTUD7A	236	Q8TE49
LERASTKMLDRWSIM	DGKH	446	Q86XP1
AEWIQRMMEVLRKRS	CXCL13	81	O43927
RAAQMEKTMRRWSDC	CCDC102A	86	Q96A19
LTMVLLFVMWMKRRE	CDH4	746	P55283
LFVMWMKRREKERHT	CDH4	751	P55283
AIWSSEMRRLMIEKI	DNAJC13	1201	O75165
FMDLLVRRRWEVMSK	FAM172BP	241	A6NC97
ELYDVTWEEMRDKMR	EMC2	6	Q15006
KWKEELLDQRRRMME	SCAPER	581	Q9BY12
MFVVWMKRRDKERQA	CDH2	741	P19022
MDSALEWLRRELREM	FAM167B	76	Q9BTA0
EMKRALMKLWRRRVV	OR10A6	296	Q8NH74
MVKKEWESMARDRRP	REXO4	396	Q9GZR2
RAWIRVALMEKRMSE	RUNDC3A	126	Q59EK9
MALHSMRKARERWSF	WARS2	1	Q9UGM6
DRRRRFLAMKWMITE	MRPS7	176	Q9Y2R9
RELDWAKVMVEKSRM	SFXN2	41	Q96NB2
MSMERRLKIEETWRL	SYNE1	7986	Q8NF91
MEMRWFLSKIQDDFR	PLCZ1	1	Q86YW0
FVEGARRDKWVMKML	GUCA1B	166	Q9UMX6
VSRMRGMWRDEKVSL	SHCBP1L	111	Q9BZQ2
GRFKDWMVSMIVDRE	STAG3L1	86	P0CL83
SWDKTERARDMKCLM	HERC2P3	796	Q9BVR0
WKMRRFAKLDMSARL	CDC42BPA	866	Q5VT25
WRKCRMRIFTVAQMD	SLC12A4	871	Q9UP95
KRIMKEAFRWALFSM	CIDEC	181	Q96AQ7
DKLRWRMKEEMDRAQ	TSG101	236	Q99816
WEHQLRRMEMDKTRE	SUGP1	496	Q8IWZ8
RRMEMDKTREWAEQL	SUGP1	501	Q8IWZ8
MMLTDRKEAASWARR	TIMELESS	421	Q9UNS1
KTRLMQWRDMFDIAV	TTC13	556	Q8NBP0
REEKFWMMDIATQRE	ZNF223	61	Q9UK11
VDMMERLRISQKWVR	VWF	1301	P04275
MRILVDLERMDWDKA	PYGM	351	P11217
RFFKAVRELMLWMDE	SPTBN2	1911	O15020
MREDRWAVIAKMDRK	SYCP1	951	Q15431
ERADLEKAWVQRRMM	SPTAN1	1426	Q13813
GRFKDWMVSMIVDRE	STAG3L2	86	P0CL84
CAKKFMWRDSFMRHR	ZBTB22	546	O15209
RAAEWQRAMTMRKVL	YEATS2	1191	Q9ULM3
RAMRMADFWLTEKDL	MRPL17	71	Q9NRX2
WFRMVLERRHFLQMK	MYO9B	966	Q13459