Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone methyltransferase binding	NCOA6 PER2 PRDM14	4.84e-05	18	80	3	GO:1990226
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	HIPK3 NOLC1 ASXL1 NCOA6 BIN1 PER2 SH2B3 DTL GON4L SIAH2 ZC3H18 SIN3A HDGFL2 MRTFA	1.90e-04	1160	80	14	GO:0030674
GeneOntologyBiologicalProcess	cell division	NEK1 SETD2 MISP BRCA2 TTC28 BUB1 MASTL AKNA NUMB ZFYVE26 CLASP2 GAREM1	1.69e-05	697	81	12	GO:0051301
GeneOntologyBiologicalProcess	neuroblast division in subventricular zone	AKNA NUMB	4.56e-05	3	81	2	GO:0021849
GeneOntologyBiologicalProcess	circadian regulation of translation	PER2 PER1	9.09e-05	4	81	2	GO:0097167
GeneOntologyBiologicalProcess	microtubule depolymerization	HTR1A NCKAP5 CLASP2 NCKAP5L	1.32e-04	66	81	4	GO:0007019
GeneOntologyBiologicalProcess	monocyte homeostasis	CSF1 SH2B3	1.51e-04	5	81	2	GO:0035702
GeneOntologyBiologicalProcess	mitotic cell cycle	TOM1L2 NOLC1 SETD2 MISP BRCA2 TTC28 DTL BUB1 MASTL CUL9 ZFYVE26 CLASP2 SIN3A	1.52e-04	1014	81	13	GO:0000278
GeneOntologyBiologicalProcess	negative regulation of hydrolase activity	DFFA BIN1 MGAT5 MASTL SIAH2 NOS1 MRTFA	1.71e-04	298	81	7	GO:0051346
GeneOntologyBiologicalProcess	chromatin organization	ASXL1 SETD2 UBN1 PER2 BRCA2 BUB1 PER1 DMRTC2 RRP8 SIN3A PRDM14 HDGFL2	1.87e-04	896	81	12	GO:0006325
GeneOntologyCellularComponent	centrosome	NEK1 MISP UBN1 TAPT1 BRCA2 TTC28 DTL CEP41 MASTL AKNA ZFYVE26 CLASP2 NCKAP5L	7.72e-06	770	81	13	GO:0005813
GeneOntologyCellularComponent	microtubule end	MISP NCKAP5 CLASP2 NCKAP5L	1.40e-05	38	81	4	GO:1990752
GeneOntologyCellularComponent	microtubule organizing center	NEK1 MISP UBN1 TAPT1 BRCA2 TTC28 DTL CEP41 MASTL AKNA ZFYVE26 CLASP2 NCKAP5L	4.94e-05	919	81	13	GO:0005815
GeneOntologyCellularComponent	microtubule plus-end	NCKAP5 CLASP2 NCKAP5L	1.71e-04	28	81	3	GO:0035371
Domain	NCKAP5_C	NCKAP5 NCKAP5L	1.81e-05	2	80	2	IPR032769
Domain	Nckap5l	NCKAP5 NCKAP5L	1.81e-05	2	80	2	IPR026163
Domain	NCKAP5	NCKAP5 NCKAP5L	1.81e-05	2	80	2	PF15246
Domain	PAH	GON4L SIN3A	5.42e-05	3	80	2	IPR003822
Domain	-	GON4L SIN3A	5.42e-05	3	80	2	1.20.1160.11
Domain	Period_circadian-like_C	PER2 PER1	5.42e-05	3	80	2	IPR022728
Domain	PAH	GON4L SIN3A	5.42e-05	3	80	2	PS51477
Domain	Period_C	PER2 PER1	5.42e-05	3	80	2	PF12114
Domain	PAH	GON4L SIN3A	5.42e-05	3	80	2	PF02671
Domain	NUT	NUTM2F NUTM2G	1.80e-04	5	80	2	IPR024310
Domain	NUT_N	NUTM2F NUTM2G	1.80e-04	5	80	2	IPR024309
Domain	NUT	NUTM2F NUTM2G	1.80e-04	5	80	2	PF12881
Domain	PAS_fold_3	PER2 PER1	4.32e-03	23	80	2	IPR013655
Domain	PAS_3	PER2 PER1	4.32e-03	23	80	2	PF08447
Domain	PAS-assoc_C	PER2 PER1	4.70e-03	24	80	2	IPR000700
Domain	PAC	PER2 PER1	5.51e-03	26	80	2	IPR001610
Domain	PAC	PER2 PER1	5.51e-03	26	80	2	SM00086
Domain	PAC	PER2 PER1	5.51e-03	26	80	2	PS50113
Domain	PAS	PER2 PER1	8.27e-03	32	80	2	SM00091
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FAM193B NCOA6 CRYBG2 DNAJC14 UBN1 PER2 SH2B3 ZNF516 PER1 AKNA CUL9 SIAH2 ZFYVE26 CLASP2 GAREM1 TRIM7	6.79e-09	1105	83	16	35748872
Pubmed	Rhythmic changes in colonic motility are regulated by period genes.	PER2 PER1 NOS1	1.31e-08	3	83	3	19926812
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	DOCK5 NCOA6 UBAP2 UBN1 BUB1 NUMB AFF1 SIN3A MRTFA GAREM1	8.19e-08	430	83	10	35044719
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NOLC1 EVL NCOA6 SETD2 ESYT2 BIN1 UBN1 ZNF516 AFF1 ZC3H18 SIN3A MRTFA	3.10e-07	774	83	12	15302935
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NOLC1 NCOA6 NEK1 ESYT2 UBAP2 TTC28 SH3D19 PAK5 DTL NUMB CLASP2 NCKAP5L	9.50e-07	861	83	12	36931259
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SETD2 UBN1 BRCA2 TTC28 ZNF516 DTL BUB1 CUL9 ZC3H18 NCKAP5L	1.42e-06	588	83	10	38580884
Pubmed	A molecular mechanism for circadian clock negative feedback.	PER2 PER1 SIN3A	3.68e-06	13	83	3	21680841
Pubmed	Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine.	PER2 PER1	5.63e-06	2	83	2	28710114
Pubmed	Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart.	PER2 PER1	5.63e-06	2	83	2	23977055
Pubmed	De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide.	PER2 PER1	5.63e-06	2	83	2	22236088
Pubmed	Expression of circadian Per1 and Per2 genes in the liver and breast tumor tissues of HER2/neu transgenic mice of different age.	PER2 PER1	5.63e-06	2	83	2	22238756
Pubmed	Masking responses to light in period mutant mice.	PER2 PER1	5.63e-06	2	83	2	21793695
Pubmed	Alterations in the expression of Per1 and Per2 induced by Aβ31-35 in the suprachiasmatic nucleus, hippocampus, and heart of C57BL/6 mouse.	PER2 PER1	5.63e-06	2	83	2	27021954
Pubmed	Prognostic relevance of Period1 (Per1) and Period2 (Per2) expression in human gastric cancer.	PER2 PER1	5.63e-06	2	83	2	24551282
Pubmed	Constant darkness is a circadian metabolic signal in mammals.	PER2 PER1	5.63e-06	2	83	2	16421573
Pubmed	Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.	PER2 PER1	5.63e-06	2	83	2	11389837
Pubmed	Circadian regulation of central ethanol sensitivity by the mPer2 gene.	PER2 PER1	5.63e-06	2	83	2	19523042
Pubmed	Cocaine sensitization and reward are under the influence of circadian genes and rhythm.	PER2 PER1	5.63e-06	2	83	2	12084940
Pubmed	Differential daily expression of Per1 and Per2 mRNA in the suprachiasmatic nucleus of fetal and early postnatal mice.	PER2 PER1	5.63e-06	2	83	2	11207804
Pubmed	Resetting the brain clock: time course and localization of mPER1 and mPER2 protein expression in suprachiasmatic nuclei during phase shifts.	PER2 PER1	5.63e-06	2	83	2	15009158
Pubmed	Insights into structure and activity relationship of clinically mutated PER1 and PER2 class A β-lactamase enzymes.	PER2 PER1	5.63e-06	2	83	2	35475497
Pubmed	Time-dependent inhibitory effect of lipopolysaccharide injection on Per1 and Per2 gene expression in the mouse heart and liver.	PER2 PER1	5.63e-06	2	83	2	20370466
Pubmed	cAMP-dependent signaling as a core component of the mammalian circadian pacemaker.	PER2 PER1	5.63e-06	2	83	2	18487196
Pubmed	Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction.	PER2 PER1	5.63e-06	2	83	2	35810166
Pubmed	Cardiac atrial circadian rhythms in PERIOD2::LUCIFERASE and per1:luc mice: amplitude and phase responses to glucocorticoid signaling and medium treatment.	PER2 PER1	5.63e-06	2	83	2	23110090
Pubmed	Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1.	PER2 PER1	5.63e-06	2	83	2	33053337
Pubmed	Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice.	PER2 PER1	5.63e-06	2	83	2	24603368
Pubmed	The circadian clock protects against ionizing radiation-induced cardiotoxicity.	PER2 PER1	5.63e-06	2	83	2	31919902
Pubmed	Period gene expression in mouse endocrine tissues.	PER2 PER1	5.63e-06	2	83	2	12775559
Pubmed	Circadian time-dependent tumor suppressor function of period genes.	PER2 PER1	5.63e-06	2	83	2	19926612
Pubmed	Forebrain oscillators ticking with different clock hands.	PER2 PER1	5.63e-06	2	83	2	17996461
Pubmed	Circadian gene expression is resilient to large fluctuations in overall transcription rates.	PER2 PER1	5.63e-06	2	83	2	19078963
Pubmed	The circadian clock and tumor suppression by mammalian period genes.	PER2 PER1	5.63e-06	2	83	2	15817328
Pubmed	Low reproductive success in Per1 and Per2 mutant mouse females due to accelerated ageing?	PER2 PER1	5.63e-06	2	83	2	18367514
Pubmed	Temporal expression profiles of ceramide and ceramide-related genes in wild-type and mPer1/mPer2 double knockout mice.	PER2 PER1	5.63e-06	2	83	2	21773940
Pubmed	Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant mice.	PER2 PER1	5.63e-06	2	83	2	12383239
Pubmed	Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain.	PER2 PER1	5.63e-06	2	83	2	19477955
Pubmed	Mice lacking Period 1 and Period 2 circadian clock genes exhibit blue cone photoreceptor defects.	PER2 PER1	5.63e-06	2	83	2	23351077
Pubmed	Circadian clock genes Per1 and Per2 regulate the response of metabolism-associated transcripts to sleep disruption.	PER2 PER1	5.63e-06	2	83	2	23285241
Pubmed	Core circadian clock genes Per1 and Per2 regulate the rhythm in photoreceptor outer segment phagocytosis.	PER2 PER1	5.63e-06	2	83	2	34160105
Pubmed	Iron accumulation with age alters metabolic pattern and circadian clock gene expression through the reduction of AMP-modulated histone methylation.	PER2 PER1	5.63e-06	2	83	2	35460695
Pubmed	Robust circadian rhythmicity of Per1 and Per2 mutant mice in constant light, and dynamics of Per1 and Per2 gene expression under long and short photoperiods.	PER2 PER1	5.63e-06	2	83	2	12054191
Pubmed	Inhibition of light- or glutamate-induced mPer1 expression represses the phase shifts into the mouse circadian locomotor and suprachiasmatic firing rhythms.	PER2 PER1	5.63e-06	2	83	2	9920673
Pubmed	Endogenous circadian reporters reveal functional differences of PERIOD paralogs and the significance of PERIOD:CK1 stable interaction.	PER2 PER1	5.63e-06	2	83	2	36724252
Pubmed	mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning.	PER2 PER1	5.63e-06	2	83	2	15959842
Pubmed	Influence of photoperiod duration and light-dark transitions on entrainment of Per1 and Per2 gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus.	PER2 PER1	5.63e-06	2	83	2	19840112
Pubmed	Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency†.	PER2 PER1	5.63e-06	2	83	2	30452546
Pubmed	Differential effects of two period genes on the physiology and proteomic profiles of mouse anterior tibialis muscles.	PER2 PER1	5.63e-06	2	83	2	17202855
Pubmed	Light-induced phase shifts in mice lacking mPER1 or mPER2.	PER2 PER1	5.63e-06	2	83	2	12693867
Pubmed	Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate anxiety-related behavior.	PER2 PER1	5.63e-06	2	83	2	23039899
Pubmed	Cones are required for normal temporal responses to light of phase shifts and clock gene expression.	PER2 PER1	5.63e-06	2	83	2	20560710
Pubmed	Light responsiveness of clock genes, Per1 and Per2, in the olfactory bulb of mice.	PER2 PER1	5.63e-06	2	83	2	21624349
Pubmed	Circadian period 2: a missing beneficial factor in sickle cell disease by lowering pulmonary inflammation, iron overload, and mortality.	PER2 PER1	5.63e-06	2	83	2	31260634
Pubmed	Phase shifts and Per gene expression in mouse suprachiasmatic nucleus.	PER2 PER1	5.63e-06	2	83	2	12824769
Pubmed	Methamphetamine-induced, suprachiasmatic nucleus-independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse.	PER2 PER1	5.63e-06	2	83	2	12372028
Pubmed	Circadian rhythms of hedonic drinking behavior in mice.	PER2 PER1	5.63e-06	2	83	2	28286126
Pubmed	Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins.	PER2 PER1	5.63e-06	2	83	2	26862173
Pubmed	Age and oestrus cycle-related changes in glucocorticoid excretion and wheel-running activity in female mice carrying mutations in the circadian clock genes Per1 and Per2.	PER2 PER1	5.63e-06	2	83	2	18786554
Pubmed	Physiological and Molecular Dissection of Daily Variance in Exercise Capacity.	PER2 PER1	5.63e-06	2	83	2	31006590
Pubmed	Per1/Per2 knockout Affects Spleen Immune Function in Elderly Mice via Inducing Spleen Lymphocyte Ferroptosis.	PER2 PER1	5.63e-06	2	83	2	36361751
Pubmed	Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis.	PER2 PER1	5.63e-06	2	83	2	24091726
Pubmed	A suprachiasmatic-independent circadian clock(s) in the habenula is affected by Per gene mutations and housing light conditions in mice.	PER2 PER1	5.63e-06	2	83	2	30242505
Pubmed	Deregulated expression of the Per1 and Per2 in human gliomas.	PER2 PER1	5.63e-06	2	83	2	20481271
Pubmed	Expression of the circadian clock genes Per1 and Per2 in sporadic and familial breast tumors.	PER2 PER1	5.63e-06	2	83	2	17971899
Pubmed	Stromal Expression of the Core Clock Gene Period 2 Is Essential for Tumor Initiation and Metastatic Colonization.	PER2 PER1	5.63e-06	2	83	2	33123539
Pubmed	Time-place learning and memory persist in mice lacking functional Per1 and Per2 clock genes.	PER2 PER1	5.63e-06	2	83	2	24336415
Pubmed	Distinct phase relationships between suprachiasmatic molecular rhythms, cerebral cortex molecular rhythms, and behavioral rhythms in early runner (CAST/EiJ) and nocturnal (C57BL/6J) mice.	PER2 PER1	5.63e-06	2	83	2	23024437
Pubmed	The circadian Per1 and Per2 genes influence alcohol intake, reinforcement, and blood alcohol levels.	PER2 PER1	5.63e-06	2	83	2	23608482
Pubmed	Circadian rhythms in Per1, PER2 and Ca2+ of a solitary SCN neuron cultured on a microisland.	PER2 PER1	5.63e-06	2	83	2	31797953
Pubmed	Disruption of clock gene expression alters responses of the aryl hydrocarbon receptor signaling pathway in the mouse mammary gland.	PER2 PER1	5.63e-06	2	83	2	17715397
Pubmed	Host circadian behaviors exert only weak selective pressure on the gut microbiome under stable conditions but are critical for recovery from antibiotic treatment.	PER2 PER1	5.63e-06	2	83	2	36350921
Pubmed	Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance.	PER2 PER1	5.63e-06	2	83	2	24770415
Pubmed	Rigid Cooperation of Per1 and Per2 proteins.	PER2 PER1	5.63e-06	2	83	2	27609640
Pubmed	Dentate nNOS accounts for stress-induced 5-HT1A receptor deficiency: Implication in anxiety behaviors.	HTR1A NOS1	5.63e-06	2	83	2	31863649
Pubmed	Lack of food anticipation in Per2 mutant mice.	PER2 PER1	5.63e-06	2	83	2	17055980
Pubmed	Daily variation in global and local DNA methylation in mouse livers.	PER2 PER1	5.63e-06	2	83	2	25689298
Pubmed	Per1/Per2 Disruption Reduces Testosterone Synthesis and Impairs Fertility in Elderly Male Mice.	PER2 PER1	5.63e-06	2	83	2	35806403
Pubmed	Chronic circadian disturbance by a shortened light-dark cycle increases mortality.	PER2 PER1	5.63e-06	2	83	2	22154820
Pubmed	Numb is an endocytic protein.	DPYSL2 NUMB	5.63e-06	2	83	2	11121447
Pubmed	Differential expressions of mPer1 and mPer2 mRNAs under a skeleton photoperiod and a complete light-dark cycle.	PER2 PER1	5.63e-06	2	83	2	12531511
Pubmed	Circadian gene expression in the murine larynx.	PER2 PER1	5.63e-06	2	83	2	18346860
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	TOM1L2 NOLC1 EVL NEK1 SETD2 CEP41 PER1 NUMB CLASP2 NCKAP5L MRTFA GAREM1	6.47e-06	1038	83	12	26673895
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NCOA6 NEK1 SETD2 DPYSL2 UBAP2 TTC28 SH3D19 NUMB SIN3A	6.65e-06	549	83	9	38280479
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	FAM193B NEK1 MISP ESYT2 TTC28 CLASP2	1.13e-05	209	83	6	36779422
Pubmed	Discovery and refinement of loci associated with lipid levels.	SETD2 BRCA2 SBNO1 AFF1 CUBN TBL2	1.19e-05	211	83	6	24097068
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	NOLC1 FAM193B NEK1 SETD2 DPYSL2 UBAP2 SH3D19 MASTL NUMB SIN3A HDGFL2	1.37e-05	934	83	11	33916271
Pubmed	Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects.	PER2 PER1	1.69e-05	3	83	2	19013183
Pubmed	PER1 interaction with GPX1 regulates metabolic homeostasis under oxidative stress.	PER2 PER1	1.69e-05	3	83	2	32896721
Pubmed	Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.	PER2 PER1	1.69e-05	3	83	2	11165242
Pubmed	Clock proteins and training modify exercise capacity in a daytime-dependent manner.	PER2 PER1	1.69e-05	3	83	2	34426495
Pubmed	Abnormal circadian locomotor rhythms and Per gene expression in six-month-old triple transgenic mice model of Alzheimer's disease.	PER2 PER1	1.69e-05	3	83	2	29626648
Pubmed	A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.	PER2 PER1	1.69e-05	3	83	2	9428527
Pubmed	Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice.	PER2 PER1	1.69e-05	3	83	2	26781276
Pubmed	Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.	PER2 PER1	1.69e-05	3	83	2	9427249
Pubmed	Association between polymorphisms in period genes and bone density in postmenopausal Korean women.	PER2 PER1	1.69e-05	3	83	2	24678593
Pubmed	Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations.	PER2 PER1	1.69e-05	3	83	2	27912059
Pubmed	Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics.	PER2 PER1	1.69e-05	3	83	2	29478834
Pubmed	Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals.	PER2 PER1	1.69e-05	3	83	2	30773466
Pubmed	Photic entrainment of period mutant mice is predicted from their phase response curves.	PER2 PER1	1.69e-05	3	83	2	20826680
Pubmed	A tunable artificial circadian clock in clock-defective mice.	PER2 PER1	1.69e-05	3	83	2	26617050
Interaction	YWHAZ interactions	NOLC1 EVL DFFA ASXL1 NEK1 DPYSL2 BIN1 TXLNA PER2 SH2B3 TTC28 SH3D19 PAK5 DTL NUMB CLASP2 ZC3H18 NCKAP5L NOS1 GAREM1 TRIM7	3.58e-08	1319	81	21	int:YWHAZ
Interaction	SPSB3 interactions	DOCK5 DPYSL2 LYPD1 NUMB	1.45e-05	37	81	4	int:SPSB3
Cytoband	20q11	ASXL1 NCOA6	4.82e-05	6	83	2	20q11
Cytoband	2q14	BIN1 BUB1	1.76e-04	11	83	2	2q14
Cytoband	2q21.2	LYPD1 NCKAP5	2.90e-04	14	83	2	2q21.2
Cytoband	Ensembl 112 genes in cytogenetic band chr8p21	DOCK5 DPYSL2 GFRA2	1.92e-03	135	83	3	chr8p21
Coexpression	BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	HIPK3 NCOA6 SETD2 HOXD1 PER2 SBNO1 PER1 GON4L NUMB ELK4 ARHGAP45 MRTFA GAREM1	1.56e-06	822	82	13	M6782
Coexpression	E2F1_UP.V1_UP	NOLC1 EVL UBN1 BRCA2 BUB1 HDGFL2	2.80e-05	188	82	6	M2632
Coexpression	GSE13411_NAIVE_BCELL_VS_PLASMA_CELL_UP	EVL BIN1 PER2 SH2B3 GON4L GAREM1	3.54e-05	196	82	6	M3243
Coexpression	GSE17721_PAM3CSK4_VS_CPG_0.5H_BMDC_UP	DOCK5 DPYSL2 BUB1 PER1 AFF1 TBL2	3.96e-05	200	82	6	M3850
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NOLC1 ASXL1 CSF1 PER2 PER1 MRTFA	1.65e-06	193	83	6	dbf0fe496254320c894568c31e5f9ce63707d1b5
Drug	Methamphetamine	PCSK1 FAM193B DPYSL2 BIN1 LYPD1 HTR1A CSF1 PER2 MYOM1 POM121L12 SH3D19 DTL PER1 MASTL GON4L CUL9 SIAH2 CUBN NOS1 GFRA2	8.35e-08	1401	82	20	ctd:D008694
Drug	Mi-1	HTR1A PER2 PER1	2.49e-06	8	82	3	CID000198746
Drug	Pirenzepine dihydrochloride [29868-97-1]; Up 200; 9.4uM; MCF7; HT_HG-U133A	HIPK3 DOCK5 BIN1 CSF1 HOXD1 CEP41 MRTFA	7.41e-06	198	82	7	2234_UP
Drug	PHA-00745360 [351320-33-7]; Down 200; 10uM; MCF7; HT_HG-U133A	HIPK3 NEK1 CRYBG2 BIN1 PER2 BUB1 MRTFA	7.91e-06	200	82	7	3907_DN
Drug	CT 0	HTR1A PER2 PER1	1.99e-05	15	82	3	CID002255489
Disease	Myeloid Leukemia, Chronic	ASXL1 PER2 PER1	5.95e-05	29	77	3	C0023473
Disease	Malignant neoplasm of breast	EVL NCOA6 SETD2 CSF1 PER2 BRCA2 SBNO1 PER1 AFF1 ZFYVE26 CUBN	1.05e-04	1074	77	11	C0006142
Disease	aspartate aminotransferase measurement	PCSK1 BIN1 MGAT5 CSF1 SH2B3 TTC28 AKNA ZC3H18 CUBN ARHGAP45	1.19e-04	904	77	10	EFO_0004736
Disease	Depression, Postpartum	HTR1A PER2	1.40e-04	7	77	2	C0221074
Disease	lifestyle measurement, diastolic blood pressure	NCKAP5 GAREM1	1.40e-04	7	77	2	EFO_0006336, EFO_0010724
Disease	vascular cell adhesion protein 1 measurement	MGAT5 SH2B3	1.40e-04	7	77	2	EFO_0020846
Disease	platelet crit	CSF1 SH2B3 TTC28 SBNO1 DTL NUMB AFF1 ZC3H18 CUBN HDGFL2	1.81e-04	952	77	10	EFO_0007985
Disease	myelofibrosis (is_implicated_in)	ASXL1 SH2B3	1.86e-04	8	77	2	DOID:4971 (is_implicated_in)
Disease	creatine kinase measurement	BIN1 CSF1 MRTFA	5.00e-04	59	77	3	EFO_0004534
Disease	Fetal Alcohol Spectrum Disorders	SLITRK2 NOS1	5.15e-04	13	77	2	C2985290
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	SETD2 SH2B3 PRDM14	5.51e-04	61	77	3	C1961102
Disease	monocyte count	TOM1L2 ASXL1 SETD2 CRYBG2 CSF1 SH2B3 ZNF516 GON4L ARHGAP45 GFRA2 MRTFA	6.11e-04	1320	77	11	EFO_0005091
Disease	cancer	PCSK1 NCOA6 UBN1 BRCA2 TTC28 MRTFA	6.30e-04	400	77	6	MONDO_0004992
Disease	monocyte percentage of leukocytes	SETD2 CRYBG2 BIN1 CSF1 SH2B3 ZNF516 ZC3H18 GFRA2	6.38e-04	731	77	8	EFO_0007989
Disease	MYELODYSPLASTIC SYNDROME	ASXL1 SH2B3 BRCA2	7.26e-04	67	77	3	C3463824
Disease	estrogen-receptor negative breast cancer	BRCA2 MRTFA GAREM1	8.60e-04	71	77	3	EFO_1000650
Disease	Fetal Alcohol Syndrome	SLITRK2 NOS1	8.91e-04	17	77	2	C0015923
Disease	Juvenile Myelomonocytic Leukemia	ASXL1 SH2B3	1.12e-03	19	77	2	C0349639
Disease	mean platelet volume	DOCK5 SETD2 ESYT2 UBN1 TTC28 AFF1 SIN3A ARHGAP45 MRTFA	1.34e-03	1020	77	9	EFO_0004584
Disease	lymphocyte count	SETD2 UBAP2 CSF1 SH2B3 TTC28 SBNO1 AFF1 ELK4 ARHGAP45 GFRA2 MRTFA	1.42e-03	1464	77	11	EFO_0004587
Disease	breast cancer, COVID-19	TTC28 GON4L	1.50e-03	22	77	2	MONDO_0007254, MONDO_0100096
Disease	Carcinoma of lung	MXRA5 BRCA2	1.64e-03	23	77	2	C0684249
Disease	testosterone measurement	PCSK1 DOCK5 NCOA6 MGAT5 TTC28 AKNA AFF1 SIN3A TBL2 GFRA2	1.73e-03	1275	77	10	EFO_0004908
Disease	lymphocyte percentage of leukocytes	DOCK5 SETD2 TTC28 SBNO1 AFF1 ARHGAP45 MRTFA	1.76e-03	665	77	7	EFO_0007993
Disease	prostate carcinoma	TOM1L2 BIN1 MGAT5 UBAP2 TTC28 SH3D19 SIAH2 GFRA2	2.24e-03	891	77	8	EFO_0001663
Disease	Fever	HTR1A NOS1	2.26e-03	27	77	2	C0015967
Disease	Colorectal Carcinoma	EVL DPYSL2 HOXD1 BUB1 PER1 CUBN DSCAML1	2.38e-03	702	77	7	C0009402
Disease	non-high density lipoprotein cholesterol measurement	ESYT2 SH2B3 BRCA2 SBNO1 AKNA AFF1 HDGFL2	2.60e-03	713	77	7	EFO_0005689
Disease	Bilateral Wilms Tumor	ASXL1 BRCA2	2.61e-03	29	77	2	C2930471

Protein segments in the cluster

Peptide	Gene	Start	Entry
RNLPSGKKISSNPNP	ESYT2	546	A0FGR8
CNKTLAPSPKSPGDF	BUB1	586	O43683
GPPPKNKVLSNNASS	BCORP1	31	Q8N888
PNQIKSGTPYRTPKS	MASTL	711	Q96GX5
PASCQQALPPGSARK	CEP41	271	Q9BYV8
ASKASPPGDLQNPKR	DFFA	311	O00273
SQSTPAKAPRAKCNP	DTL	426	Q9NZJ0
AKAPRAKCNPSNSSP	DTL	431	Q9NZJ0
APGAPQKNCKAVPSF	ASXL1	1196	Q8IXJ9
KGSPRPQAPKANGTS	NOLC1	536	Q14978
PRGPAKLPQSQSKSG	PAK5	351	Q9P286
KQEASKPPRGCPQAN	MISP	481	Q8IVT2
PGAAAASKPNSTVPK	DNAJC14	671	Q6Y2X3
SKKNRAGSPSPQPSG	ARHGAP45	16	Q92619
SKFGSQPIPAKRPAS	NEK1	281	Q96PY6
SSPDQAPPQLSKSKG	NCKAP5L	361	Q9HCH0
GCAFLNPKFNPPKSS	MGAT5	531	Q09328
PTKFIKNPGSPSQSQ	HOXD1	311	Q9GZZ0
NPKQASLKRPPTAGA	MYO1A	551	Q9UBC5
ASSAKTSPAKQQAPP	DPYSL2	516	Q16555
GTFKAKALPCQSPDP	PER1	581	O15534
DCKPGTSRDQQPKAP	PER2	1021	O15055
AASQPPNSSEAGRKP	EVL	311	Q9UI08
SYPRQKTPGTPKRNC	GAREM1	651	Q9H706
QPRPSAFKPLSKNGA	POM121L12	211	Q8N7R1
SSSGQSSPSPCKRPN	HIPK3	921	Q9H422
PQSSSTEPARKPGQK	HDGFL2	416	Q7Z4V5
QSPTKNGSPSKCPRF	NOS1	291	P29475
TPSPGRQNSKAPKLT	NCOA6	1341	Q14686
KFCGSKRPPNVKSSN	CUBN	3111	O60494
PPKSKPYEGSQRNST	DOCK5	1821	Q9H7D0
PGSAKQRPPRSTCQS	CSF1	246	P09603
SPAAQKAFQPPRSCG	BRCA2	3291	P51587
SPKAPNHFRKGTTQP	DMRTC2	106	Q8IXT2
PGSNKVIKPNSGPSR	GFRA2	431	O00451
DKPPQPGAKTSSRND	ELK4	126	P28324
GSQAKKSEASPAPRP	FAM193B	721	Q96PV7
SKNNRSFDTPVKGPP	DSCAML1	1636	Q8TD84
PVPGQKNSSPTNFSK	C7orf57	201	Q8NEG2
KKTRSRECNNPPPSG	C7	516	P10643
KGPCAPAASSPTQKE	CRYBG2	601	Q8N1P7
NGRPPTAAAVPKSAK	TMEM63B	756	Q5T3F8
SLQPSFNPGKTPARS	GON4L	1011	Q3T8J9
RHGASPAPQPKKSVN	HTR1A	241	P08908
PSPKQRSKQAGSSPR	AKNA	1306	Q7Z591
NINSPPPGDQARSKK	DRGX	116	A6NNA5
CNGPRPKKRGSSASA	LYPD1	106	Q8N2G4
PQSPKAGKPSAAAAS	HGSNAT	116	Q68CP4
PFSKNSKGRDRSPAP	CUL9	1446	Q8IWT3
SPKAQRPVACPKGDS	ENDOV	261	Q8N8Q3
SDNAPAKGNKSPSPP	BIN1	286	O00499
TAPSNNSSPRDSPCK	SBNO1	686	A3KN83
KPSLKDSGSRNPCPS	C3orf86	76	P0DN24
KSKQRTNPSPTNPFS	NUMB	626	P49757
AQKRGLSPSPSPASK	NUTM2F	681	A1L443
AQKRGLSPSPSPASK	NUTM2G	666	Q5VZR2
GPKPSNQEGKSPARF	PRDM14	181	Q9GZV8
GKPSVAPKPAANRAS	SH3D19	51	Q5HYK7
QCPKSQTPGSRSRPA	NCKAP5	886	O14513
TPRKCFVGQSKPNHP	SLITRK2	806	Q9H156
LPKSYQQPKCTGRTP	SIN3A	561	Q96ST3
STGPSANKPCSKQPP	SIAH2	6	O43255
RPAGNPQNASRKKSP	SSC5D	161	A1L4H1
KPSPKTVCGSPLAAQ	MRTFA	776	Q969V6
GKRSCQKSPAQQEPP	AFF1	581	P51825
AFKVPAPKTSGNPAN	CLASP2	26	O75122
APKTSGNPANSARKP	CLASP2	31	O75122
PDSLKAKFSAQPQGP	ZNF516	971	Q92618
QPKSQASKPAYGNSP	UBAP2	1101	Q5T6F2
KSTLSRCSNVPGPKP	TRIM7	286	Q9C029
DPPKSSRPKLQAACS	SH2B3	241	Q9UQQ2
ISRPPPAASSQNKGS	RRP8	21	O43159
TTAGASPGPPRNKKN	WDR46	36	O15213
KAGSPAPSNRLNDSP	SETD2	611	Q9BYW2
PSPNSPFQKVGKLAS	TTC28	2116	Q96AY4
SPFANKLQGPKASPT	UBN1	821	Q9NPG3
PATCTPGKPSSKSQN	TAPT1	471	Q6NXT6
SSQKPGACAPKSPNQ	UBXN10	76	Q96LJ8
APASNPSGRKKPERS	TOM1L2	486	Q6ZVM7
SRSPPEKPKQESQSC	ZFYVE26	701	Q68DK2
RPACQKANGFPPDKS	TBL2	41	Q9Y4P3
AKQSNPKSSPGQPEA	TXLNA	11	P40222
SAKPPAGGKSSQQPS	ZC3H18	781	Q86VM9
RASGSKPSPSPENKH	MXRA5	1251	Q9NR99
GSKPNKPSLPSSSQN	MYOM1	876	P52179
LQSAFSKNSPPKQSP	PCSK1	671	P29120