Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-7 ERVK-21 ERVK-9 ERVK-24	1.54e-06	37	46	4	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-7 ERVK-21 ERVK-9 ERVK-24	1.72e-06	38	46	4	GO:0070001
GeneOntologyMolecularFunction	zinc ion binding	TRIM21 ZACN ERVK-7 ERVK-21 UPF1 ERVK-9 ERVK-24 ESCO1 PRIM1	1.67e-04	891	46	9	GO:0008270
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	LIMK1 BMPR1B ERVK-7 ACVR1C CSNK2A3 TRRAP MTOR PRIM1 STYK1	2.46e-04	938	46	9	GO:0016772
GeneOntologyMolecularFunction	transition metal ion binding	TRIM21 ZACN ERVK-7 ERVK-21 UPF1 ERVK-9 ERVK-24 ESCO1 PRIM1 LARGE1	3.07e-04	1189	46	10	GO:0046914
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase activity	BMPR1B ACVR1C	9.61e-04	20	46	2	GO:0004675
HumanPheno	Polymicrogyria	OCA2 AHI1 TRRAP MTOR ATP6V0A2 LARGE1	2.07e-05	202	16	6	HP:0002126
Domain	FAT	TRRAP MTOR	7.01e-05	6	41	2	PF02259
Domain	PIK-rel_kinase_FAT	TRRAP MTOR	7.01e-05	6	41	2	IPR003151
Domain	FATC_dom	TRRAP MTOR	7.01e-05	6	41	2	IPR003152
Domain	PIK_FAT	TRRAP MTOR	7.01e-05	6	41	2	IPR014009
Domain	FAT	TRRAP MTOR	7.01e-05	6	41	2	PS51189
Domain	FATC	TRRAP MTOR	7.01e-05	6	41	2	PS51190
Domain	FATC	TRRAP MTOR	7.01e-05	6	41	2	SM01343
Domain	GS	BMPR1B ACVR1C	9.81e-05	7	41	2	SM00467
Domain	GS_dom	BMPR1B ACVR1C	9.81e-05	7	41	2	IPR003605
Domain	TGF_beta_GS	BMPR1B ACVR1C	9.81e-05	7	41	2	PF08515
Domain	GS	BMPR1B ACVR1C	9.81e-05	7	41	2	PS51256
Domain	Kinase-like_dom	LIMK1 BMPR1B ACVR1C CSNK2A3 TRRAP MTOR STYK1	1.59e-04	542	41	7	IPR011009
Domain	Pkinase_Tyr	LIMK1 BMPR1B ACVR1C STYK1	1.80e-04	129	41	4	PF07714
Domain	Activin_recp	BMPR1B ACVR1C	2.09e-04	10	41	2	IPR000472
Domain	Activin_recp	BMPR1B ACVR1C	2.09e-04	10	41	2	PF01064
Domain	Ser-Thr/Tyr_kinase_cat_dom	LIMK1 BMPR1B ACVR1C STYK1	2.34e-04	138	41	4	IPR001245
Domain	PNMA	MOAP1 PNMA2	2.55e-04	11	41	2	PF14893
Domain	PNMA	MOAP1 PNMA2	2.55e-04	11	41	2	IPR026523
Domain	TGFB_receptor	BMPR1B ACVR1C	3.06e-04	12	41	2	IPR000333
Domain	PI3Kc	TRRAP MTOR	5.53e-04	16	41	2	SM00146
Domain	-	TRRAP MTOR	5.53e-04	16	41	2	1.10.1070.11
Domain	PI3_4_KINASE_1	TRRAP MTOR	7.04e-04	18	41	2	PS00915
Domain	PI3_4_KINASE_2	TRRAP MTOR	7.04e-04	18	41	2	PS00916
Domain	PI3/4_kinase_cat_dom	TRRAP MTOR	7.04e-04	18	41	2	IPR000403
Domain	PI3_PI4_kinase	TRRAP MTOR	7.04e-04	18	41	2	PF00454
Domain	PI3_4_KINASE_3	TRRAP MTOR	7.04e-04	18	41	2	PS50290
Domain	Nucleotide-diphossugar_trans	A4GNT CERCAM LARGE1	9.47e-04	88	41	3	IPR029044
Domain	PROTEIN_KINASE_ATP	LIMK1 BMPR1B ACVR1C CSNK2A3 STYK1	3.17e-03	459	41	5	PS00107
Domain	Prot_kinase_dom	LIMK1 BMPR1B ACVR1C CSNK2A3 STYK1	4.15e-03	489	41	5	IPR000719
Domain	PROTEIN_KINASE_DOM	LIMK1 BMPR1B ACVR1C CSNK2A3 STYK1	4.30e-03	493	41	5	PS50011
Domain	HEAT	ODAD2 MTOR	7.19e-03	58	41	2	IPR000357
Domain	Ser/Thr_kinase_AS	LIMK1 BMPR1B ACVR1C CSNK2A3	7.61e-03	357	41	4	IPR008271
Domain	PROTEIN_KINASE_ST	LIMK1 BMPR1B ACVR1C CSNK2A3	7.99e-03	362	41	4	PS00108
Domain	Protein_kinase_ATP_BS	LIMK1 BMPR1B ACVR1C CSNK2A3	9.35e-03	379	41	4	IPR017441
Domain	Pkinase	LIMK1 BMPR1B ACVR1C CSNK2A3	9.52e-03	381	41	4	PF00069
Domain	HEAT_REPEAT	ODAD2 MTOR	1.03e-02	70	41	2	PS50077
Domain	-	ODAD2 TRRAP MTOR	1.27e-02	222	41	3	1.25.10.10
Pubmed	UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma.	UPF1 MTOR	1.71e-06	2	46	2	34520393
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9 ERVK-24	1.74e-06	18	46	3	18664271
Pubmed	DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans.	NBAS UPF1	5.13e-06	3	46	2	23828042
Pubmed	PNMA2 mediates heterodimeric interactions and antagonizes chemo-sensitizing activities mediated by members of PNMA family.	MOAP1 PNMA2	5.13e-06	3	46	2	27003254
Pubmed	A role for AKT1 in nonsense-mediated mRNA decay.	UPF1 MTOR	5.13e-06	3	46	2	34634811
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-7 ERVK-21 ERVK-9 ERVK-24	7.48e-06	94	46	4	21542922
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	LIMK1 TRIM21 BMPR1B AHI1 UPF1 MTOR	7.55e-06	358	46	6	32460013
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-7 ERVK-24	1.03e-05	4	46	2	10469592
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-7 ERVK-21	1.71e-05	5	46	2	12629516
Pubmed	The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.	MTOR ATP6V0A2	7.65e-05	10	46	2	27244671
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	TRRAP MTOR	7.65e-05	10	46	2	18160036
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	TRRAP MTOR	9.34e-05	11	46	2	20427287
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	MRPL39 TRIM21 TRRAP SPTB	1.11e-04	187	46	4	26460568
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-21 ERVK-9	1.12e-04	12	46	2	14557543
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	AHI1 MTOR	2.58e-04	18	46	2	33323119
Pubmed	OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.	TRIM21 MTOR	3.54e-04	21	46	2	30662561
Pubmed	Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.	BOC OCA2	5.04e-04	25	46	2	29475039
Pubmed	AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.	UPF1 TRRAP	6.79e-04	29	46	2	20371770
Pubmed	The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.	ACVR1C LARGE1	6.79e-04	29	46	2	18077674
Pubmed	DHHC protein family targets different subsets of glioma stem cells in specific niches.	UPF1 MTOR	8.80e-04	33	46	2	30658672
Pubmed	Exome sequencing supports a de novo mutational paradigm for schizophrenia.	TRRAP MTOR	1.29e-03	40	46	2	21822266
Interaction	ERVK-21 interactions	TRIM21 ERVK-21	4.45e-06	2	43	2	int:ERVK-21
GeneFamily	Type 1 receptor serine/threonine kinases	BMPR1B ACVR1C	5.56e-05	7	30	2	345
GeneFamily	Paraneoplastic Ma antigens	MOAP1 PNMA2	1.45e-04	11	30	2	671
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Ptrf\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ODAD2 ACVR1C KCNJ2 KCNH4	8.24e-06	133	43	4	a1bc34e5dda4ff4716b857931cc196f6770f58f4
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Macc1_Lrg1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ODAD2 ACVR1C KCNJ2 KCNH4	1.07e-05	142	43	4	d08e1880425d285c4433014fe0242ac7ff7734af
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	NAALAD2 KCNJ2 LARGE1 PNMA2	1.54e-05	156	43	4	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue\|TCGA-Breast / Sample_Type by Project: Shred V9	NAALAD2 ACVR1C LRRC3B SLC7A10	2.37e-05	174	43	4	0f3ec0d0d4344e10c9b48adc9174123f6402dc51
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue-3\|TCGA-Breast / Sample_Type by Project: Shred V9	NAALAD2 ACVR1C LRRC3B SLC7A10	2.37e-05	174	43	4	7f8f5fafae08676d2b90cab9802c3c9320f1370e
ToppCell	TCGA-Breast-Solid_Tissue_Normal\|TCGA-Breast / Sample_Type by Project: Shred V9	NAALAD2 ACVR1C LRRC3B SLC7A10	2.37e-05	174	43	4	e2f240d60bffbe8e6d60f0bb405b231bd3c96875
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue\|TCGA-Breast / Sample_Type by Project: Shred V9	NAALAD2 ACVR1C LRRC3B SLC7A10	2.37e-05	174	43	4	1aadbf2642b6d1320ceabd92e6ff59e11f16c315
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	BOC CERCAM SFRP4 PNMA2	3.77e-05	196	43	4	d5ed41fa111750e6b363c04cccc40a47dd774852
Drug	CHCl	BOC CPT1B ATP6V0A2 PNMA2	5.66e-06	65	41	4	CID006432229
Disease	visceral adipose tissue measurement, body mass index	NBAS SLC7A10 LARGE1	2.26e-04	87	40	3	EFO_0004340, EFO_0004765
Disease	Ovarian Mucinous Adenocarcinoma	TRRAP MTOR	8.13e-04	31	40	2	C1335167
Disease	Large cell carcinoma of lung	TRRAP MTOR	8.66e-04	32	40	2	C0345958
Disease	sleep apnea measurement, obstructive sleep apnea	NBAS SMCO2	9.21e-04	33	40	2	EFO_0003918, EFO_0007817
Disease	hoarding disorder	LRRC3B SLC7A10	1.10e-03	36	40	2	EFO_0803361
Disease	retinal nerve fibre layer thickness measurement	NBAS OCA2	1.56e-03	43	40	2	EFO_0600004
Disease	Gastric Adenocarcinoma	BMPR1B TRRAP	1.71e-03	45	40	2	C0278701
Disease	amino acid measurement	GHRHR NBAS ODAD2 SUSD1 STYK1	2.14e-03	678	40	5	EFO_0005134
Disease	Uveal Melanoma	OCA2 THNSL2	2.36e-03	53	40	2	EFO_1000616
Disease	Metastatic melanoma	BMPR1B MTOR	2.45e-03	54	40	2	C0278883

Protein segments in the cluster

Peptide	Gene	Start	Entry
TVIWMGDRLMSLEHR	ERVK-9	531	Q9UKH3
SRVLSMACLMLLTWV	SLC7A10	161	Q9NS82
GCYDSMIRIWKVEMR	AHI1	716	Q8N157
ELMTRMLRVWCKLED	A4GNT	226	Q9UNA3
CEALRVMGRIMRECW	ACVR1C	451	Q8NER5
RWSSDECLRQMGKLM	BMPR1B	456	O00238
RLSRGRVWAMIIMLC	OCA2	416	Q04671
MRMTCPLCRRLWARS	HAGHL	241	Q6PII5
IAMRDGKLCLMWRVG	KCNJ2	201	P63252
NRRMCAEMAGITWAI	OR10S1	151	Q8NGN2
WRLTAERELMGMLST	LARGE1	316	O95461
MTLRLLEDWCRGMDM	MOAP1	1	Q96BY2
MSRRMCVGLVILSWI	OR4K3	136	Q96R72
MACIWYVIGRREMEA	KCNH4	376	Q9UQ05
MNLVDLWLTRSLSMC	LRRC3B	1	Q96PB8
MALALLEDWCRIMSV	PNMA2	1	Q9UL42
SLGWCRRMMRRYDLS	POGK	306	Q9P215
PWVRLATVMLTRCTM	NBAS	2196	A2RRP1
AMCSDDWLLVRMKIR	OOSP4B	11	A0A2R8Y4Y8
CWTLMTMAIRIIDRA	PRIM1	131	P49642
WLRDMRLMQGDEICL	UPF1	361	Q92900
WRLGCMLASMIFRKE	CSNK2A3	216	Q8NEV1
MTAWRGMRPEVTLAC	BOC	6	Q9BWV1
TVIWMGDRLMSLEHR	ERVK-24	421	P61566
TVIWMGDRLMSLEHR	ERVK-7	421	P61567
MDRRMWGAHVFCVLS	GHRHR	1	Q02643
TVIWMGDRLMSLEHR	ERVK-21	531	P61565
ICGISRIWVFSMMRR	ESCO1	766	Q5FWF5
RMLASLWEMEISGRV	CERCAM	336	Q5T4B2
IWAMCIRLLSSRHPM	CPT1B	151	Q92523
LMLGRMRCLEALGEW	MTOR	1476	P42345
MEALAMGSRALRLWL	MRPL39	1	Q9NYK5
MMIIDRLDGVRLLWS	ODAD2	831	Q5T2S8
MLMLRDTIEDLSRQW	THNSL2	461	Q86YJ6
LLQLWMGCRATRTLM	INTS5	176	Q6P9B9
VMWVGMRLLQRRGDC	NLRP9	426	Q7RTR0
LWTCRRDVMTMDGLL	STYK1	206	Q6J9G0
WRSRMMLLENCLVEK	SFRP4	261	Q6FHJ7
CLRWRSIKTADMEEM	SUSD1	506	Q6UWL2
MARDLLSWMESIIRQ	SPTB	1911	P11277
MLGCRTTWDLREMRE	SMCO2	316	A6NFE2
RLTMMWEEVTCPICL	TRIM21	6	P19474
MSSMLLLRLSWLDTR	ZACN	81	Q401N2
IRATAPMWRCSRIMH	TRRAP	3291	Q9Y4A5
LSDVLWAMLMRVGLR	ATP6V0A2	766	Q9Y487
MRLTLLCCTWREERM	LIMK1	1	P53667
MAESRGRLYLWMCLA	NAALAD2	1	Q9Y3Q0