Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	PCDHB4 PCDHB3 RGN PCDHB16 PCDHB14 USP32 PCDHB9	1.51e-04	749	32	7	GO:0005509
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	RDH10 SDR9C7	6.72e-04	24	32	2	GO:0004745
GeneOntologyMolecularFunction	single-stranded RNA binding	PABPC5 DDX12P POLR2G	7.37e-04	111	32	3	GO:0003727
GeneOntologyMolecularFunction	alcohol dehydrogenase (NAD+) activity	RDH10 SDR9C7	7.89e-04	26	32	2	GO:0004022
GeneOntologyMolecularFunction	alcohol dehydrogenase [NAD(P)+] activity	RDH10 SDR9C7	1.05e-03	30	32	2	GO:0018455
GeneOntologyBiologicalProcess	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.76e-08	53	32	5	GO:0016339
GeneOntologyBiologicalProcess	synapse assembly	DOCK7 PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	6.90e-06	308	32	6	GO:0007416
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	9.58e-06	187	32	5	GO:0007156
GeneOntologyBiologicalProcess	neuroinflammatory response	SMO MMP9 IL33 CD200	1.75e-05	101	32	4	GO:0150076
GeneOntologyBiologicalProcess	regulation of neuroinflammatory response	MMP9 IL33 CD200	4.92e-05	46	32	3	GO:0150077
GeneOntologyBiologicalProcess	synapse organization	DOCK7 PCDHB4 PCDHB3 PCDHB16 PCDHB14 KIF2C PCDHB9	7.04e-05	685	32	7	GO:0050808
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.12e-04	313	32	5	GO:0098742
GeneOntologyBiologicalProcess	cell junction assembly	DOCK7 PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	2.11e-04	569	32	6	GO:0034329
GeneOntologyBiologicalProcess	kidney development	RDH10 CFH RGN SMO MMP9	2.51e-04	372	32	5	GO:0001822
GeneOntologyBiologicalProcess	renal system development	RDH10 CFH RGN SMO MMP9	2.97e-04	386	32	5	GO:0072001
Domain	Cadherin_C_2	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	7.31e-09	42	31	5	PF16492
Domain	Cadherin_C	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	7.31e-09	42	31	5	IPR032455
Domain	Cadherin_N	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	6.92e-08	65	31	5	IPR013164
Domain	Cadherin_2	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	6.92e-08	65	31	5	PF08266
Domain	Cadherin_CS	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	9.29e-07	109	31	5	IPR020894
Domain	Cadherin	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.11e-06	113	31	5	PF00028
Domain	CADHERIN_1	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.11e-06	113	31	5	PS00232
Domain	CADHERIN_2	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.16e-06	114	31	5	PS50268
Domain	-	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.16e-06	114	31	5	2.60.40.60
Domain	CA	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.21e-06	115	31	5	SM00112
Domain	Cadherin-like	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.27e-06	116	31	5	IPR015919
Domain	Cadherin	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.38e-06	118	31	5	IPR002126
Domain	Sc_DH/Rdtase_CS	RDH10 SDR9C7	1.53e-03	35	31	2	IPR020904
Domain	ADH_SHORT	RDH10 SDR9C7	3.49e-03	53	31	2	PS00061
Domain	adh_short	RDH10 SDR9C7	3.75e-03	55	31	2	PF00106
Domain	SDR_fam	RDH10 SDR9C7	3.88e-03	56	31	2	IPR002347
Domain	WD40	SMU1 LLGL2 DNAI3	8.90e-03	259	31	3	PF00400
Domain	WD40	SMU1 LLGL2 DNAI3	9.76e-03	268	31	3	SM00320
Domain	WD40_repeat	SMU1 LLGL2 DNAI3	1.02e-02	272	31	3	IPR001680
Domain	WD_REPEATS_1	SMU1 LLGL2 DNAI3	1.08e-02	278	31	3	PS00678
Domain	WD_REPEATS_2	SMU1 LLGL2 DNAI3	1.09e-02	279	31	3	PS50082
Domain	WD_REPEATS_REGION	SMU1 LLGL2 DNAI3	1.09e-02	279	31	3	PS50294
Domain	WD40_repeat_dom	SMU1 LLGL2 DNAI3	1.29e-02	297	31	3	IPR017986
Domain	-	SMU1 LLGL2 DNAI3	1.75e-02	333	31	3	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SMU1 LLGL2 DNAI3	1.77e-02	335	31	3	IPR015943
Pubmed	Protocadherins.	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	6.08e-13	13	32	5	12231349
Pubmed	The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	7.29e-12	20	32	5	11322959
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.92e-09	57	32	5	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	2.10e-09	58	32	5	30377227
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	4.75e-09	68	32	5	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	6.36e-09	72	32	5	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	7.32e-09	74	32	5	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	8.96e-09	77	32	5	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.09e-08	80	32	5	10716726
Pubmed	Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system.	PCDHB4 PCDHB3 SYP	4.77e-07	17	32	3	18279309
Pubmed	Mechanisms involved in enhancement of matrix metalloproteinase-9 expression in macrophages by interleukin-33.	MMP9 IL33	8.20e-07	2	32	2	28105703
Pubmed	IL-33 Can Promote the Process of Pulmonary Fibrosis by Inducing the Imbalance Between MMP-9 and TIMP-1.	MMP9 IL33	2.46e-06	3	32	2	29417309
Pubmed	Interleukin-33, matrix metalloproteinase-9, and tissue inhibitor [corrected] of matrix metalloproteinase-1 in myocardial infarction.	MMP9 IL33	2.46e-06	3	32	2	23525523
Pubmed	IL‑33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-κB pathway.	MMP9 IL33	4.92e-06	4	32	2	28849217
Pubmed	Identification of novel cadherins expressed in human melanoma cells.	PCDHB16 PCDHB14	1.72e-05	7	32	2	9182820
Pubmed	Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.	PCDHB4 PCDHB3 PCDHB16	2.22e-05	59	32	3	23754746
Pubmed	Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.	DOCK7 SYP	2.94e-05	9	32	2	21041412
Pubmed	Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin.	SMO CD200	5.38e-05	12	32	2	20050020
Pubmed	Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function.	SMO MMP9	7.41e-05	14	32	2	16935278
Pubmed	A unique role of cohesin-SA1 in gene regulation and development.	PCDHB16 PCDHB14	9.76e-05	16	32	2	22415368
Pubmed	Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.	PCDHB16 PCDHB14	1.39e-04	19	32	2	23920377
Pubmed	Gamma protocadherins are required for survival of spinal interneurons.	SYP PCDHB16	2.63e-04	26	32	2	12467588
Pubmed	Roles and functions of HIV-1 Tat protein in the CNS: an overview.	MMP9 POLR2G	2.84e-04	27	32	2	24359561
Pubmed	Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice.	PCDHB3 PCDHB16	3.05e-04	28	32	2	33523829
Pubmed	Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome.	CFH SMO	4.00e-04	32	32	2	36920550
Pubmed	Analysis of mouse embryonic patterning and morphogenesis by forward genetics.	SMO DDX12P	4.25e-04	33	32	2	15755804
Pubmed	Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin.	MMP9 IL33	5.65e-04	38	32	2	27653694
Interaction	PCDHB9 interactions	PCDHB3 PCDHB9	7.32e-06	3	32	2	int:PCDHB9
Interaction	PCDHB4 interactions	PCDHB4 PCDHB3	7.32e-06	3	32	2	int:PCDHB4
Interaction	PCDHB10 interactions	PCDHB3 PCDHB16	5.10e-05	7	32	2	int:PCDHB10
Interaction	PCDHB3 interactions	PCDHB4 PCDHB3 PCDHB16 PCDHB9	7.09e-05	141	32	4	int:PCDHB3
Cytoband	5q31	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.72e-08	115	32	5	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	1.94e-06	298	32	5	chr5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr1p22	CLCA4 DNAI3	4.13e-03	137	32	2	chr1p22
GeneFamily	Clustered protocadherins	PCDHB4 PCDHB3 PCDHB16 PCDHB14 PCDHB9	2.94e-08	64	26	5	20
GeneFamily	Short chain dehydrogenase/reductase superfamily	RDH10 SDR9C7	5.31e-03	76	26	2	743
GeneFamily	WD repeat domain containing	SMU1 LLGL2 DNAI3	6.11e-03	262	26	3	362
Coexpression	GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN	BEND4 IL33 ATG12 CD200 POLR2G	4.19e-06	200	32	5	M5600
Disease	pleural tuberculosis (is_marker_for)	MMP9 IL33	4.18e-05	10	29	2	DOID:106 (is_marker_for)
Disease	membranous glomerulonephritis (biomarker_via_orthology)	CFH MMP9	8.43e-05	14	29	2	DOID:10976 (biomarker_via_orthology)
Disease	ocular hypertension (biomarker_via_orthology)	SMO MMP9	1.26e-04	17	29	2	DOID:9282 (biomarker_via_orthology)
Disease	squamous cell carcinoma (is_marker_for)	CFH MMP9	1.58e-04	19	29	2	DOID:1749 (is_marker_for)
Disease	glaucoma (is_marker_for)	CFH MMP9	1.75e-04	20	29	2	DOID:1686 (is_marker_for)
Disease	stomach cancer (is_marker_for)	RGN SMO MMP9	3.64e-04	142	29	3	DOID:10534 (is_marker_for)
Disease	colorectal cancer (is_marker_for)	SMO MMP9 KIF2C	4.88e-04	157	29	3	DOID:9256 (is_marker_for)
Disease	tongue squamous cell carcinoma (is_marker_for)	MMP9 IL33	6.08e-04	37	29	2	DOID:0050865 (is_marker_for)
Disease	Drug-Induced Liver Disease	CFH RGN MMP9 POLR2G	6.27e-04	404	29	4	C0860207
Disease	Drug-Induced Acute Liver Injury	CFH RGN MMP9 POLR2G	6.27e-04	404	29	4	C3658290
Disease	Hepatitis, Toxic	CFH RGN MMP9 POLR2G	6.27e-04	404	29	4	C0019193
Disease	Chemically-Induced Liver Toxicity	CFH RGN MMP9 POLR2G	6.27e-04	404	29	4	C4279912
Disease	Chemical and Drug Induced Liver Injury	CFH RGN MMP9 POLR2G	6.27e-04	404	29	4	C4277682
Disease	Hepatitis, Drug-Induced	CFH RGN MMP9 POLR2G	6.27e-04	404	29	4	C1262760
Disease	very long-chain saturated fatty acid measurement	DOCK7 HSPA13	8.60e-04	44	29	2	EFO_0006796
Disease	Liver Cirrhosis, Experimental	RDH10 DOCK7 RGN MMP9 IL33	8.63e-04	774	29	5	C0023893

Protein segments in the cluster

Peptide	Gene	Start	Entry
FVFTTDELKYSCGLG	BEND4	421	Q6ZU67
YGEEVTYKCFEGFGI	CFH	951	P08603
CTKFFVGTEEGEVIY	DNAI3	631	Q8IWG1
VGTLYECFGSDGKLV	ATG12	116	O94817
FTFLGKEYSTCTSEG	MMP9	351	P14780
SGIASCVFTKYGQGF	LLGL2	896	Q6P1M3
ITEGCVSKYSGVFSF	TUBGCP6	1616	Q96RT7
FSGVYGTCIGATNKF	MFSD11	256	O43934
FGFGKISGTACLTVY	CD200	126	P41217
KGFGVVCFSSFEEAT	PABPC5	341	Q96DU9
EVCLTGDSGTGEFKF	PCDHB4	751	Q9Y5E5
YEVCLTGGSETSEFK	PCDHB16	751	Q9NRJ7
YEVCLTGGSGTNEFK	PCDHB14	751	Q9Y5E9
VECFAFGISGVQKYT	IL33	91	O95760
EGICSGKYFTESGLV	DOCK7	1761	Q96N67
AVIGGGYCVSKFGVE	SDR9C7	166	Q8NEX9
GVVSGGVVCFFPSYE	DDX12P	716	Q92771
TYCSVGVFFPGTGKV	HSPA13	41	P48723
IFEGGKATCFAYGQT	KIF2C	336	Q99661
YEVCLTGGSGTNEFK	PCDHB3	751	Q9Y5E6
YEVCLTGGSETGEFK	PCDHB9	751	Q9Y5E1
YAVKVIDVTGGGSFS	PHKG1	46	Q16816
TCRGGTTKVFLVGDY	SYP	86	P08247
VCFTKGYGSYIEGTG	TRDMT1	291	O14717
SGGYVATIGTKFCAL	RGN	66	Q15493
GVEDYCASKFGVVGF	RDH10	206	Q8IZV5
GGTSICSGIKYAFQV	CLCA4	381	Q14CN2
FTEVEGTCTGKYGFV	POLR2G	31	P62487
GTCTGKYGFVIAVTT	POLR2G	36	P62487
GEDFVLYCFSTVTGK	SMU1	461	Q2TAY7
VDGDSVSGICFVGYK	SMO	381	Q99835
VECGKGFSFSSDYII	ZNF23	591	P17027
AEVIYCSFGGTSKGL	USP32	61	Q8NFA0