Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR10 TLR1	8.99e-05	4	78	2	GO:0035663
Domain	L_dom-like	TLR10 ERBB3 FMOD LRRC53 TLR1 ADGRA2 ERBIN PPP1R42 TLR8 NLRP3	1.35e-06	328	80	10	IPR032675
Domain	LRR	TLR10 FMOD LRRC53 TLR1 ADGRA2 ERBIN PPP1R42 TLR8	2.34e-06	201	80	8	PS51450
Domain	Leu-rich_rpt	TLR10 FMOD LRRC53 TLR1 ADGRA2 ERBIN PPP1R42 TLR8 NLRP3	2.36e-06	271	80	9	IPR001611
Domain	LRR_8	TLR10 FMOD LRRC53 TLR1 ADGRA2 ERBIN TLR8	8.64e-06	171	80	7	PF13855
Domain	-	TLR10 FMOD LRRC53 TLR1 ADGRA2 ERBIN PPP1R42 TLR8 NLRP3	9.30e-06	321	80	9	3.80.10.10
Domain	Leu-rich_rpt_typical-subtyp	TLR10 FMOD LRRC53 TLR1 ADGRA2 ERBIN TLR8	1.08e-05	177	80	7	IPR003591
Domain	LRR_TYP	TLR10 FMOD LRRC53 TLR1 ADGRA2 ERBIN TLR8	1.08e-05	177	80	7	SM00369
Domain	LRR_1	TLR10 FMOD TLR1 ADGRA2 ERBIN PPP1R42 TLR8	4.26e-05	219	80	7	PF00560
Domain	TIR	TLR10 TLR1 TLR8	9.52e-05	21	80	3	SM00255
Domain	TIR	TLR10 TLR1 TLR8	1.10e-04	22	80	3	PF01582
Domain	-	TLR10 TLR1 TLR8	1.26e-04	23	80	3	3.40.50.10140
Domain	TIR	TLR10 TLR1 TLR8	1.44e-04	24	80	3	PS50104
Domain	TIR_dom	TLR10 TLR1 TLR8	1.63e-04	25	80	3	IPR000157
Domain	Toll-like_receptor	TLR10 TLR1	1.80e-04	5	80	2	IPR017241
Domain	Cys-rich_flank_reg_C	TLR10 TLR1 ADGRA2 TLR8	6.03e-04	90	80	4	IPR000483
Domain	LRRCT	TLR10 TLR1 ADGRA2 TLR8	6.03e-04	90	80	4	SM00082
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH14	1.59e-03	14	80	2	IPR024317
Domain	AAA_8	DNAH12 DNAH14	1.59e-03	14	80	2	PF12780
Domain	DHC_fam	DNAH12 DNAH14	1.83e-03	15	80	2	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DNAH14	1.83e-03	15	80	2	IPR004273
Domain	Dynein_heavy	DNAH12 DNAH14	1.83e-03	15	80	2	PF03028
Domain	ARM-type_fold	FOCAD PDS5B VPS11 PKP4 RICTOR LYST	3.33e-03	339	80	6	IPR016024
Domain	Actinin_actin-bd_CS	SYNE1 SPTBN1	4.32e-03	23	80	2	IPR001589
Domain	Spectrin	SYNE1 SPTBN1	4.32e-03	23	80	2	PF00435
Domain	ACTININ_2	SYNE1 SPTBN1	4.32e-03	23	80	2	PS00020
Domain	ACTININ_1	SYNE1 SPTBN1	4.32e-03	23	80	2	PS00019
Domain	PAS	NCOA2 KCNH1	5.10e-03	25	80	2	PF00989
Domain	PAS_fold	NCOA2 KCNH1	5.10e-03	25	80	2	IPR013767
Domain	PAC	NCOA2 KCNH1	5.51e-03	26	80	2	IPR001610
Domain	PAC	NCOA2 KCNH1	5.51e-03	26	80	2	SM00086
Domain	SAM	CNKSR3 MAP3K20 TP73	6.39e-03	88	80	3	SM00454
Domain	Spectrin_repeat	SYNE1 SPTBN1	6.82e-03	29	80	2	IPR002017
Domain	SAM_DOMAIN	CNKSR3 MAP3K20 TP73	7.89e-03	95	80	3	PS50105
Domain	Spectrin/alpha-actinin	SYNE1 SPTBN1	8.27e-03	32	80	2	IPR018159
Domain	PAS	NCOA2 KCNH1	8.27e-03	32	80	2	SM00091
Domain	SPEC	SYNE1 SPTBN1	8.27e-03	32	80	2	SM00150
Domain	SAM	CNKSR3 MAP3K20 TP73	8.36e-03	97	80	3	IPR001660
Pathway	WP_MYD88_DISTINCT_INPUTOUTPUT_PATHWAY	TLR10 TLR1 TLR8	3.93e-05	18	53	3	M39478
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	PDS5B VPS11 SERPINA1 PSMG2 SLC12A2 SYNE1 PKP4 CNKSR3 NAA10 ALG8 RICTOR PIGO F13A1	1.59e-08	719	83	13	35337019
Pubmed	The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes.	TLR10 TLR1 TLR8	4.56e-07	7	83	3	19924287
Pubmed	Polymorphism in 3'-untranslated region of toll-like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation.	TLR10 TLR1 TLR8	1.09e-06	9	83	3	20977567
Pubmed	Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.	TLR10 TLR1 TLR8	1.55e-06	10	83	3	20227302
Pubmed	A family of human receptors structurally related to Drosophila Toll.	TLR10 TLR1 TLR8	1.55e-06	10	83	3	9435236
Pubmed	[Expression of toll-like receptors in human epidermal keratinocytes].	TLR10 TLR1 TLR8	1.55e-06	10	83	3	18686608
Pubmed	Toll-like receptors.	TLR10 TLR1 TLR8	1.55e-06	10	83	3	11782555
Pubmed	Toll-like receptors.	TLR10 TLR1 TLR8	2.13e-06	11	83	3	18394314
Pubmed	Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients.	TLR10 TLR1 TLR8	4.68e-06	14	83	3	20595247
Pubmed	Toll-like receptor 1 and 10 polymorphisms, Helicobacter pylori susceptibility and risk of gastric lesions in a high-risk Chinese population.	TLR10 TLR1	5.63e-06	2	83	2	25687912
Pubmed	Ginsenoside Rg1 ameliorates aging‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice.	NOX4 NLRP3	5.63e-06	2	83	2	34523690
Pubmed	Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives.	ERBB3 IKZF4	5.63e-06	2	83	2	34448034
Pubmed	Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.	NPC1 NLRP3	5.63e-06	2	83	2	30054450
Pubmed	Toll-like receptor 1 and 10 gene polymorphisms are linked to postbronchiolitis asthma in adolescence.	TLR10 TLR1	5.63e-06	2	83	2	28692144
Pubmed	NOX4 Signaling Mediates Cancer Development and Therapeutic Resistance through HER3 in Ovarian Cancer Cells.	ERBB3 NOX4	5.63e-06	2	83	2	34209278
Pubmed	Genetic polymorphisms in TLR1, TLR2, TLR4, and TLR10 of Helicobacter pylori-associated gastritis: a prospective cross-sectional study in Thailand.	TLR10 TLR1	5.63e-06	2	83	2	28368946
Pubmed	Interaction between Erbin and a Catenin-related protein in epithelial cells.	PKP4 ERBIN	5.63e-06	2	83	2	11711544
Pubmed	Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis.	NOX4 NLRP3	5.63e-06	2	83	2	34530693
Pubmed	Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection.	TLR10 TLR1	5.63e-06	2	83	2	26559190
Pubmed	Alpha1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro.	SERPINA1 ST14	5.63e-06	2	83	2	18723439
Pubmed	Toll-like receptor 1 and 10 variations increase asthma risk and review highlights further research directions.	TLR10 TLR1	5.63e-06	2	83	2	30924193
Pubmed	ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells.	PKP4 ERBIN	5.63e-06	2	83	2	12047349
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SLC12A2 SPTBN1 CNKSR3 MAP3K20 NAA10 SIK1 RICTOR PLEKHM3 LYST ERBIN PHLDB2	6.40e-06	861	83	11	36931259
Pubmed	Natural selection in the TLR-related genes in the course of primate evolution.	TLR10 TLR1 TLR8	7.18e-06	16	83	3	18810425
Pubmed	Binding specificity of Toll-like receptor cytoplasmic domains.	TLR10 TLR1 TLR8	1.24e-05	19	83	3	16482509
Pubmed	Toll-like receptor signaling pathway variants and prostate cancer mortality.	TLR10 TLR1 TLR8	1.24e-05	19	83	3	19505919
Pubmed	Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.	TLR10 TLR1	1.69e-05	3	83	2	18752252
Pubmed	IFNs activate toll-like receptor gene expression in viral infections.	TLR1 TLR8	1.69e-05	3	83	2	11607792
Pubmed	Increased expression of hepcidin and toll-like receptors 8 and 10 in viral keratitis.	TLR10 TLR8	1.69e-05	3	83	2	21499082
Pubmed	Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.	TLR10 TLR1	1.69e-05	3	83	2	22150367
Pubmed	Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.	TLR10 TLR1	1.69e-05	3	83	2	15812078
Pubmed	Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.	TLR10 TLR1	1.69e-05	3	83	2	28123183
Pubmed	Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.	TLR10 TLR1	1.69e-05	3	83	2	17932345
Pubmed	Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells.	PKP4 ERBIN	1.69e-05	3	83	2	12370826
Pubmed	HIV-1 infection induces interleukin-1β production via TLR8 protein-dependent and NLRP3 inflammasome mechanisms in human monocytes.	TLR8 NLRP3	1.69e-05	3	83	2	24939850
Pubmed	Human NLRP3 inflammasome activation is Nox1-4 independent.	NOX4 NLRP3	1.69e-05	3	83	2	20407038
Pubmed	Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.	TLR10 TLR1	1.69e-05	3	83	2	25028161
Pubmed	[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].	TLR10 TLR1	1.69e-05	3	83	2	25850295
Pubmed	Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity.	SERPINA1 ST14	1.69e-05	3	83	2	28362108
Pubmed	Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.	TLR10 TLR1	1.69e-05	3	83	2	18091991
Pubmed	Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses.	TLR10 TLR1	1.69e-05	3	83	2	23151486
Pubmed	Toll-like receptor heterodimer variants protect from childhood asthma.	TLR10 TLR1	3.37e-05	4	83	2	18547625
Pubmed	Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1.	SERPINA1 ST14	3.37e-05	4	83	2	18550704
Pubmed	Association of Toll-like receptor polymorphisms with HIV status in North Americans.	TLR1 TLR8	3.37e-05	4	83	2	25253287
Pubmed	Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population.	TLR10 TLR1	3.37e-05	4	83	2	20815312
Pubmed	Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.	TLR10 TLR1	3.37e-05	4	83	2	20348427
Pubmed	Meat and fiber intake and interaction with pattern recognition receptors (TLR1, TLR2, TLR4, and TLR10) in relation to colorectal cancer in a Danish prospective, case-cohort study.	TLR10 TLR1	3.37e-05	4	83	2	29566186
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PDS5B ATAD3C TTC16 PCDHGA7 PCDHGA5 SYNE1 SPTBN1 CNKSR3 TENM1 SIK1 SPG11 LYST ERBIN	3.59e-05	1442	83	13	35575683
Pubmed	Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.	PKP4 ADGRA2 ERBIN	3.68e-05	27	83	3	24550280
Pubmed	A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.	ERBB3 IKZF4	5.60e-05	5	83	2	18198356
Pubmed	A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling.	PKP4 ERBIN	5.60e-05	5	83	2	16203728
Pubmed	Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk.	TLR10 TLR1	5.60e-05	5	83	2	16537705
Pubmed	Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.	TLR10 TLR1	5.60e-05	5	83	2	22703024
Pubmed	A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.	TLR10 TLR1	5.60e-05	5	83	2	19029192
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	LLGL2 SLC12A2 PKP4 RICTOR GNAT1 ERBIN ST14 PHLDB2	6.57e-05	569	83	8	30639242
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	LLGL2 AP3M2 RICTOR GTPBP10 ST14	7.95e-05	183	83	5	31932471
Pubmed	Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88.	TLR10 TLR1	8.39e-05	6	83	2	15728506
Pubmed	Structural and functional understanding of the toll-like receptors.	TLR10 TLR1	8.39e-05	6	83	2	33576548
Pubmed	Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases.	TLR10 TLR1	1.17e-04	7	83	2	18776592
Pubmed	Functional expression of pattern recognition receptors in tissues of the human female reproductive tract.	TLR10 TLR8	1.17e-04	7	83	2	19406482
Pubmed	Identification of genetic loci associated with Helicobacter pylori serologic status.	TLR10 TLR1	1.17e-04	7	83	2	23652523
Pubmed	Isolated Toll-like receptor transmembrane domains are capable of oligomerization.	TLR10 TLR1	1.17e-04	7	83	2	23155421
Pubmed	Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13.	PDS5B FRY	1.56e-04	8	83	2	8812419
Pubmed	The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF.	PKP4 ERBIN	1.56e-04	8	83	2	11821434
Pubmed	Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.	TLR1 TLR8	1.56e-04	8	83	2	20100933
Pubmed	Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.	TLR10 TLR1	1.56e-04	8	83	2	11561001
Pubmed	Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide.	RICTOR TLR8	1.56e-04	8	83	2	24740015
Pubmed	Proteomic profiling of Myc-associated proteins.	PDS5B KNDC1 ERBIN PHLDB2	1.65e-04	114	83	4	21150319
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	ERBB3 DNAH12 DNAH14	1.97e-04	47	83	3	8812413
Pubmed	Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.	LYST NLRP3	2.00e-04	9	83	2	22387558
Pubmed	Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.	TLR1 TLR8	2.00e-04	9	83	2	24091496
Pubmed	LZTR1 is a regulator of RAS ubiquitination and signaling.	SLC12A2 SPTBN1 RICTOR ERBIN	2.49e-04	127	83	4	30442766
Pubmed	High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.	ADGRA2 TLR8	2.50e-04	10	83	2	12730667
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	ERBB3 SLC12A2 PKP4 SPTBN1 RICTOR ERBIN	2.92e-04	377	83	6	38117590
Pubmed	Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors.	SPTBN1 ERBIN	3.05e-04	11	83	2	39256359
Pubmed	Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation.	SLC12A2 NLRP3	3.66e-04	12	83	2	25959047
Pubmed	Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE.	TLR10 TLR1	3.66e-04	12	83	2	19254290
Pubmed	Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.	ERBB3 PSMG2 SLC35F4	3.68e-04	58	83	3	17554300
Pubmed	Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population.	SERPINA1 F13A1	4.31e-04	13	83	2	17003923
Pubmed	Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.	TLR10 TLR8	5.03e-04	14	83	2	14625308
Pubmed	YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes.	TLR1 TLR8	5.03e-04	14	83	2	34206257
Pubmed	Mast cells as sensors of cell injury through IL-33 recognition.	TLR1 TLR8	5.03e-04	14	83	2	21239713
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	LLGL2 SLC12A2 PKP4 RICTOR ERBIN PHLDB2	5.23e-04	421	83	6	36976175
Pubmed	Expression of Toll-like receptors in the developing brain.	TLR1 TLR8	6.61e-04	16	83	2	22666391
Pubmed	A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.	TLR10 TLR8	6.61e-04	16	83	2	16024789
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	TDRD15 SLC12A2 SYNE1 ADAMTS15	7.17e-04	168	83	4	30631154
Pubmed	Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.	ERBB3 IKZF4	7.48e-04	17	83	2	22951725
Pubmed	Lp(a) and risk of recurrent cardiac events in obese postinfarction patients.	PON1 F13A1	7.48e-04	17	83	2	18927546
Pubmed	Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.	ERBB3 PSMG2	7.48e-04	17	83	2	17554260
Pubmed	Jun and JunD-dependent functions in cell proliferation and stress response.	ERBB3 NOX4	7.48e-04	17	83	2	20300111
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	TLR10 NPC1 THAP2 SERPINA1 SPTBN1 NOX4 RICTOR ESPL1 ERBIN F13A1	1.01e-03	1293	83	10	15342556
Pubmed	Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.	NOX4 GTPBP10	1.04e-03	20	83	2	23824729
Pubmed	Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.	PON1 DLX6	1.04e-03	20	83	2	16341224
Pubmed	Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.	ERBB3 PSMG2	1.04e-03	20	83	2	18978792
Pubmed	Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians.	PON1 F13A1	1.15e-03	21	83	2	20227257
Pubmed	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors.	TLR1 TLR8	1.26e-03	22	83	2	31729371
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	NPC1 SLC12A2 TENM1 SPG11 PLEKHM3 LYST	1.32e-03	504	83	6	34432599
Pubmed	Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.	ITGA10 SIK1	1.38e-03	23	83	2	25190801
Pubmed	Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.	ERBB3 IKZF4	1.63e-03	25	83	2	21829393
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	NPC1 KCNH1 SYNE1 ADGRA2	1.75e-03	214	83	4	22199357
GeneFamily	CD molecules\|Toll like receptors	TLR10 TLR1 TLR8	3.90e-06	10	59	3	948
GeneFamily	Dyneins, axonemal	DNAH12 DNAH14	1.38e-03	17	59	2	536
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	NPC1 FOCAD SYNE1 PKP4 SPTBN1 CNKSR3 SIK1 PCNX1 RICTOR PLEKHM3 ERBIN PIGO SEMA4G PHLDB2	7.56e-06	1102	82	14	M2369
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	NPC1 FOCAD SYNE1 PKP4 SPTBN1 CNKSR3 SIK1 PCNX1 RICTOR PLEKHM3 ERBIN PIGO SEMA4G PHLDB2	9.45e-06	1124	82	14	MM1070
Coexpression	GAO_ESOPHAGUS_25W_C1_CILIATED_EPITHELIAL_CELLS	DNAH12 TTC16 ABCA13 SYNE1 AP3M2 KNDC1 PPP1R42 IKZF4 TP73	1.35e-05	459	82	9	M39136
Coexpression	GSE18893_TCONV_VS_TREG_2H_TNF_STIM_DN	SERPINA1 FRY TLR1 PLEKHM3 ERBIN NLRP3	3.34e-05	194	82	6	M7306
Coexpression	GSE9006_1MONTH_VS_4MONTH_POST_TYPE_1_DIABETES_DX_PBMC_UP	SERPINA1 TLR1 MAP3K20 DLX6 ADGRA2 NLRP3	3.74e-05	198	82	6	M5790
Coexpression	GSE27786_CD4_TCELL_VS_NKTCELL_UP	MTSS1 ADAMTS15 AP3M2 NAA10 NOCT IKZF4	3.96e-05	200	82	6	M4824
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 MTSS1 SIK1 LYST ERBIN TLR8 F13A1	5.06e-08	182	83	7	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	Control-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	FRY SLC12A2 SYNE1 SPTBN1 ITGA10 NOX4 CHRM2	6.31e-08	188	83	7	88b3415e33db81726dd29c1f50c886e057af50a0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 LLGL2 ABCA13 SYNE1 PKP4 CCDC178 DNAH14	6.79e-08	190	83	7	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NPC1 LLGL2 SYNE1 LINC00269 TENM1 AP3M2 PHLDB2	8.69e-08	197	83	7	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	RSV-Healthy-0\|RSV / Virus stimulation, Condition and Cluster	LLGL2 TLR1 MTSS1 PLEKHM3 IKZF4 TP73	1.10e-06	180	83	6	974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCell	RSV-Healthy-0\|Healthy / Virus stimulation, Condition and Cluster	LLGL2 TLR1 MTSS1 PLEKHM3 IKZF4 TP73	1.10e-06	180	83	6	703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 SIK1 LYST ERBIN TLR8 F13A1	1.29e-06	185	83	6	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FRY SLC12A2 SYNE1 SPTBN1 ITGA10 CHRM2	1.46e-06	189	83	6	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC12A2 SYNE1 SPTBN1 ITGA10 NOX4 CHRM2	1.51e-06	190	83	6	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC12A2 SYNE1 SPTBN1 ITGA10 NOX4 CHRM2	1.56e-06	191	83	6	f229abf69a1217194f74b0502486907e07dba989
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MTSS1 TENM1 DLX6 METAP1D SEMA4G SLC35F4	1.60e-06	192	83	6	bf1943715085c4124b1675888b0615c9500ec888
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MTSS1 TENM1 DLX6 METAP1D SEMA4G SLC35F4	1.81e-06	196	83	6	7af6c5147ac859353504d19727dbe24f63a29dd4
ToppCell	Neuronal-Inhibitory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MTSS1 TENM1 DLX6 METAP1D SEMA4G SLC35F4	2.03e-06	200	83	6	9ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMOD SIK1 PPP1R42 TLR8 F13A1	1.20e-05	159	83	5	323cb4a2416d2e6bff0a3f225d2edeae9ab7dc76
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NOX4 FTMT F13A1 DNAH14 PHLDB2	1.71e-05	171	83	5	9e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCell	droplet-Marrow-nan-3m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHM3 LYST TLR8 F13A1 NLRP3	1.71e-05	171	83	5	992df143d76f9e7fb1997a8996f61e941f0f9d4f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LNX2 NOX4 F13A1 DNAH14 PHLDB2	1.76e-05	172	83	5	92e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FOCAD PCDHGA5 ADAMTS15 PLEKHM3 FANCM	1.76e-05	172	83	5	da959c1abadafd79b7a0088a25eb8ef8efa3a0c2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LNX2 NOX4 F13A1 DNAH14 PHLDB2	1.86e-05	174	83	5	2947e5906b172d149412fa4e77476fce4ea695d2
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A2 ABCA13 SYNE1 PCNX1 PPP1R42	1.91e-05	175	83	5	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA13 SYNE1 MTSS1 ADAMTS15 SLC35F4	1.96e-05	176	83	5	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	Ciliated_cells-B-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	DNAH12 TTC16 ABCA13 PPP1R42 TP73	2.02e-05	177	83	5	c38138fb5ad9766c2d240811210c854338cd612e
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	SYNE1 TLR1 NOX4 TLR8 NLRP3	2.13e-05	179	83	5	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SERPINA1 TLR1 MTSS1 F13A1 NLRP3	2.13e-05	179	83	5	dc03b9045510eb1bb934329646bb92dd06890ce9
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SERPINA1 TLR1 MTSS1 F13A1 NLRP3	2.13e-05	179	83	5	330c1326ba93bb8f32559ee1cc40e357cc44ad8d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K20 TENM1 ADAMTS15 DLX6 METAP1D	2.25e-05	181	83	5	7704f236831cffe4f2a75d4c461eb88b4177e206
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAP3K20 CEACAM16 TENM1 ADAMTS15 METAP1D	2.25e-05	181	83	5	153709b4dd3d81e09f251fa8765b58bed1932fda
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 FMOD MAP3K20 ADAMTS15 PHLDB2	2.31e-05	182	83	5	ffe500d78a89dc6b4d05bab1664e7f30c94fb8d9
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 FMOD MAP3K20 ADAMTS15 PHLDB2	2.43e-05	184	83	5	94748f63947db79a6b4540e3090a63689fdd9452
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 SIK1 PLEKHM3 LYST ERBIN	2.43e-05	184	83	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 FMOD MAP3K20 ADAMTS15 PHLDB2	2.43e-05	184	83	5	819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA13 SYNE1 PKP4 TENM1 DNAH14	2.56e-05	186	83	5	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 LLGL2 MALRD1 PKP4 CCDC178	2.62e-05	187	83	5	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	COPD-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	FRY SLC12A2 SYNE1 SPTBN1 ITGA10	2.69e-05	188	83	5	1aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Adult / Lineage, Cell type, age group and donor	SYNE1 SPTBN1 ITGA10 NOX4 CHRM2	2.69e-05	188	83	5	e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 LLGL2 MALRD1 PKP4 CCDC178	2.69e-05	188	83	5	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 LLGL2 MALRD1 PKP4 CCDC178	2.76e-05	189	83	5	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	NCOA2 FRY SYNE1 PKP4 ADAMTS15	2.76e-05	189	83	5	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC12A2 PKP4 SPTBN1 CNKSR3 NOCT	2.90e-05	191	83	5	a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB3 LLGL2 SLC12A2 ST14 SEMA4G	2.90e-05	191	83	5	a8d77095ba20b47fc70ba04f80759fbce873253d
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	DNAH12 TTC16 ABCA13 PPP1R42 TP73	2.90e-05	191	83	5	e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NPC1 ERBB3 LLGL2 SLC12A2 PHLDB2	3.05e-05	193	83	5	1fdfe08b0c82248545c29b504ac259b093fde29b
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINA1 TLR1 MTSS1 LYST TLR8	3.05e-05	193	83	5	cb0fb21510124883e716780bea46575620c366b8
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NPC1 ERBB3 LLGL2 SLC12A2 PHLDB2	3.05e-05	193	83	5	5f90e3e526032d82d9dc7e0813fe79ca28dc0719
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINA1 TLR1 MTSS1 LYST TLR8	3.05e-05	193	83	5	0c207879f994c227dcd1322faa69ec9e3749cdaa
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINA1 TLR1 MTSS1 LYST TLR8	3.05e-05	193	83	5	0fbbfcc803edc3cd96b35467ad5cc573af07fd67
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SERPINA1 MAP3K20 LYST ERBIN TLR8	3.05e-05	193	83	5	4fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	DNAH12 ABCA13 KNDC1 PPP1R42 TP73	3.13e-05	194	83	5	756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SERPINA1 MAP3K20 LYST ERBIN TLR8	3.13e-05	194	83	5	885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SERPINA1 MAP3K20 LYST TLR8 NLRP3	3.13e-05	194	83	5	b191851b2287afc8c47320f5488fd22e2a454aa6
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MTSS1 DLX6 METAP1D SEMA4G SLC35F4	3.13e-05	194	83	5	4f758718a1233c25c25d99fc1b7b06f906b8b0a2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MTSS1 TENM1 DLX6 METAP1D SLC35F4	3.13e-05	194	83	5	02a9cc821c2b14aa7d0e55661a5fab66364474e1
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MTSS1 NOCT LYST TLR8 NLRP3	3.13e-05	194	83	5	dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCell	distal-Hematologic-Nonclassical_Monocyte-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SERPINA1 TLR1 MTSS1 LYST TLR8	3.21e-05	195	83	5	935461e849ca4d17627341b3ae5124d497793a91
ToppCell	Adult-Immune-monocyte-D231\|Adult / Lineage, Cell type, age group and donor	TLR1 MTSS1 LYST F13A1 NLRP3	3.21e-05	195	83	5	ea24da6fea1487acb1e56c28c0649858cc0a12bd
ToppCell	distal-2-Hematologic-Nonclassical_Monocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SERPINA1 TLR1 MTSS1 LYST TLR8	3.21e-05	195	83	5	34bed73e4dae34b0f1076b7ff9dc7ea2096c1796
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINA1 TLR1 MTSS1 LYST TLR8	3.21e-05	195	83	5	01da7115e38c280fb0baff2032b62bdb609bad5e
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	LLGL2 TTC16 SYNE1 PCNX1 ERBIN	3.21e-05	195	83	5	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	DNAH12 ABCA13 SYNE1 SPTBN1 CNKSR3	3.29e-05	196	83	5	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	LLGL2 TTC16 SYNE1 PCNX1 ERBIN	3.29e-05	196	83	5	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SERPINA1 ERBB3 LLGL2 MALRD1 SLC12A2	3.29e-05	196	83	5	4deaadb9796b907b7480fb7af5ed76ebad240850
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LLGL2 TTC16 SYNE1 PCNX1 ERBIN	3.29e-05	196	83	5	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	DNAH12 ABCA13 SYNE1 SPTBN1 CNKSR3	3.29e-05	196	83	5	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LLGL2 TTC16 SYNE1 PCNX1 ERBIN	3.29e-05	196	83	5	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LLGL2 TTC16 SYNE1 PCNX1 ERBIN	3.29e-05	196	83	5	c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell	COVID-19-lung-Capillary_Aerocytes\|lung / Disease (COVID-19 only), tissue and cell type	FRY SLC12A2 SYNE1 SPTBN1 CHRM2	3.29e-05	196	83	5	4ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell	T_cells-CTLs\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	LLGL2 TTC16 SYNE1 SPG11 LYST	3.37e-05	197	83	5	28117cf300e169182571fbad0de1681a484a435a
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FRY LLGL2 TTC16 SYNE1 MTSS1	3.45e-05	198	83	5	88bb764b21ca50e56f6c536a2d61d35afd8c3f36
ToppCell	remission-Non-classical_Monocyte\|World / disease stage, cell group and cell class	SERPINA1 MTSS1 KNDC1 LYST TLR8	3.45e-05	198	83	5	1c170655070acca00520b7cf9c510a04c0a90a8f
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PAPPA2 SERPINA1 FRY FMOD ITGA10	3.45e-05	198	83	5	c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PAPPA2 SERPINA1 FRY FMOD ITGA10	3.45e-05	198	83	5	55f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A2 KCNH1 SPTBN1 MAP3K20 ERBIN	3.53e-05	199	83	5	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FMOD ITGA10 SIK1 ADGRA2 PHLDB2	3.53e-05	199	83	5	dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB3 LLGL2 SLC12A2 ST14 SEMA4G	3.53e-05	199	83	5	7540973d36f78cd9f13210635ff0708d20c8b209
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FMOD ITGA10 SIK1 ADGRA2 PHLDB2	3.53e-05	199	83	5	c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCell	367C-Endothelial_cells-Endothelial-A_(Artery)\|367C / Donor, Lineage, Cell class and subclass (all cells)	FRY PKP4 CNKSR3 ITGA10 CCDC178	3.53e-05	199	83	5	29ed081bd5204a32068b420f2244f3704891547b
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FRY SLC12A2 SPTBN1 ITGA10 CHRM2	3.53e-05	199	83	5	14a7c4cf4bb3d43fd32ec9cc74f6625b225ffaa1
ToppCell	367C-Endothelial_cells-Endothelial-A_(Artery)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	FRY PKP4 CNKSR3 ITGA10 CCDC178	3.53e-05	199	83	5	c2d85f80037f209a4a329790f475d9f98f590262
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FRY SYNE1 SPTBN1 ITGA10 CHRM2	3.62e-05	200	83	5	3767abc75176779198505ebc6967d55ce322d9fe
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ERBB3 LLGL2 ABCA13 SPTBN1 ST14	3.62e-05	200	83	5	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	distal-1-Endothelial-Capillary_Aerocyte\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FRY SLC12A2 SPTBN1 ITGA10 NOX4	3.62e-05	200	83	5	59bacd738433cec6d05624a25fdfc087fb3ca3b5
ToppCell	Biopsy_Other_PF-Immune-Monocytes\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SERPINA1 MTSS1 NOCT F13A1 NLRP3	3.62e-05	200	83	5	83bca55d48aae8885deb83e15b2684910e4c3358
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LLGL2 TTC16 SEMA4G PHLDB2	4.99e-05	108	83	4	d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB3 MALRD1 SLC12A2 CEACAM16	6.16e-05	114	83	4	b350140b389f8762c77a37df473081e1127a8972
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)-\|Striatum / BrainAtlas - Mouse McCarroll V32	PAPPA2 FMOD ITGA10 NOX4	1.15e-04	134	83	4	a3547a68012d879d4dfe80394eace70808722e43
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)\|Striatum / BrainAtlas - Mouse McCarroll V32	PAPPA2 FMOD ITGA10 NOX4	1.15e-04	134	83	4	9458e2d0dbc18d9025b66b59f3ecc2fbc5384940
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Tshz2-Syt2_(Layer_5a,_Entorhinal_cortex,_Tshz1+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PAPPA2 DNAH12 ABCA13	1.18e-04	51	83	3	adc73d6909d75ad432aef884dae540b7e48cecd6
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage-PVM_Mrc1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TLR1 TLR8 F13A1 NLRP3	1.69e-04	148	83	4	d3ea907f8f408e9bb97ed223a3089e403e35f911
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Thalamus / BrainAtlas - Mouse McCarroll V32	KCNH1 DLX6 CHRM2 SLC35F4	1.69e-04	148	83	4	afebb64365c94b9476494bffe7c364677f19c8cf
ToppCell	Thalamus-Neuronal-Inhibitory\|Thalamus / BrainAtlas - Mouse McCarroll V32	KCNH1 DLX6 CHRM2 SLC35F4	1.69e-04	148	83	4	5f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TLR10 PKP4 FANCM F13A1	1.73e-04	149	83	4	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TLR10 F13A1 NLRP3 TP73	1.78e-04	150	83	4	8b781ec3e6c2adf052d46d724e2aef72b0c27d13
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TLR10 F13A1 NLRP3 TP73	1.78e-04	150	83	4	17da17f01a3d41ac7df20f806e3eae30eca06982
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TLR10 F13A1 NLRP3 TP73	1.78e-04	150	83	4	8702d5bb419d5e997d388e8f7e0365ba5d1de8d5
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TLR10 PKP4 FANCM F13A1	1.78e-04	150	83	4	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SYNE1 ADAMTS15 PON1	1.97e-04	154	83	4	71ffc23a2e02e27cabbdbeaa622e59e9f4a4cd9d
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 SYNE1 ADAMTS15 PON1	1.97e-04	154	83	4	46155f36d3983f637b55d7525b675c8828f6ab2e
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	AP3M2 PCNX1 RICTOR NOCT	2.07e-04	156	83	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-C_(Capillary_Aerocyte_)\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	FRY SLC12A2 SYNE1 CHRM2	2.12e-04	157	83	4	84f629b7f589ca8a1abc220fa740c4a6fdc1b579
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALG8 LYST TLR8 F13A1	2.17e-04	158	83	4	ad1040bce6ad655c2502d9abb02507ecff177f83
Drug	3M-011	TLR10 TLR1 LYST TLR8	2.07e-07	15	82	4	CID003322418
Disease	colorectal adenocarcinoma (is_marker_for)	NCOA2 ERBB3 RICTOR TP73	8.38e-07	27	80	4	DOID:0050861 (is_marker_for)
Disease	anti-Helicobacter pylori serum IgG measurement	TLR10 TLR1	2.17e-05	3	80	2	EFO_0005247
Disease	ragulator complex protein LAMTOR3 measurement	SERPINA1 PON1	4.34e-05	4	80	2	EFO_0801986
Disease	asthma, allergic disease	TLR10 ERBB3 TLR1 IKZF4	6.45e-05	79	80	4	MONDO_0004979, MONDO_0005271
Disease	aspartate aminotransferase, cytoplasmic measurement	SERPINA1 PON1	7.22e-05	5	80	2	EFO_0008031
Disease	arteriosclerosis (is_implicated_in)	SERPINA1 PON1 F13A1	8.17e-05	31	80	3	DOID:2349 (is_implicated_in)
Disease	breast ductal carcinoma (is_marker_for)	RICTOR TP73	2.01e-04	8	80	2	DOID:3007 (is_marker_for)
Disease	pulse pressure measurement	NPC1 PAPPA2 TDRD15 PSMG2 MALRD1 SLC12A2 TTC16 ADAMTS15 NOX4 FTMT GTPBP10 CHRM2	3.58e-04	1392	80	12	EFO_0005763
Disease	glucose-dependent insulinotropic peptide measurement, glucose tolerance test	PAPPA2 F13A1	6.47e-04	14	80	2	EFO_0004307, EFO_0008464
Disease	Asbestosis	SERPINA1 NLRP3	6.47e-04	14	80	2	C0003949
Disease	Pulmonary Fibrosis - from Asbestos Exposure	SERPINA1 NLRP3	6.47e-04	14	80	2	C2930617
Disease	Lung Neoplasms	SERPINA1 ERBB3 PON1 RICTOR TP73	7.81e-04	265	80	5	C0024121
Disease	Malignant neoplasm of lung	SERPINA1 ERBB3 PON1 RICTOR TP73	7.95e-04	266	80	5	C0242379
Disease	squamous cell carcinoma	NOX4 ERBIN IKZF4	8.11e-04	67	80	3	EFO_0000707
Disease	prostate cancer (is_marker_for)	NCOA2 ERBB3 PON1 TP73	8.70e-04	156	80	4	DOID:10283 (is_marker_for)
Disease	hepatocellular carcinoma (is_marker_for)	ERBB3 KCNH1 PON1 RICTOR TP73	1.38e-03	301	80	5	DOID:684 (is_marker_for)
Disease	household income	NPC1 ERBB3 MAP3K20 PCNX1 IKZF4	1.44e-03	304	80	5	EFO_0009695
Disease	Epilepsy, Cryptogenic	SLC12A2 KCNH1 CHRM2	1.46e-03	82	80	3	C0086237
Disease	Awakening Epilepsy	SLC12A2 KCNH1 CHRM2	1.46e-03	82	80	3	C0751111
Disease	Aura	SLC12A2 KCNH1 CHRM2	1.46e-03	82	80	3	C0236018
Disease	Nasopharyngeal carcinoma	ERBB3 SYNE1	1.62e-03	22	80	2	C2931822
Disease	FEV/FEC ratio	SERPINA1 ERBB3 LLGL2 DNAH12 PCDHGA5 MAP3K20 TRPM8 FTMT IKZF4 PHLDB2	1.76e-03	1228	80	10	EFO_0004713
Disease	Sarcosine measurement	PCDHGA7 PCDHGA5	1.77e-03	23	80	2	EFO_0021668
Disease	Bipolar Disorder	SERPINA1 ERBB3 ABCA13 SYNE1 PON1 CHRM2	1.90e-03	477	80	6	C0005586
Disease	mental development measurement	PCDHGA7 PCDHGA5	2.09e-03	25	80	2	EFO_0008230
Disease	apolipoprotein A 1 measurement	NPC1 NCOA2 PAPPA2 DYM MAP3K20 ITGA10 SPG11 DDB2	2.11e-03	848	80	8	EFO_0004614
Disease	peak expiratory flow	PAPPA2 SERPINA1 FRY PCDHGA5 CNKSR3 PHLDB2	2.35e-03	498	80	6	EFO_0009718
Disease	lung small cell carcinoma (is_implicated_in)	RICTOR TP73	2.62e-03	28	80	2	DOID:5409 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRSSYASQHSQLGQD	PKP4	386	Q99569
HRLASQNYSDSLAQQ	ERC2-IT1	96	O76042
LNYNTNSSHALRQLR	ERBB3	121	P21860
LTNLRTFAADHNYLQ	ERBIN	321	Q96RT1
TISAHYNLRLLGSSN	LINC00269	86	Q8N2A0
NASNALTLAHQLRVY	ADGRA2	436	Q96PE1
NNDSIRHIILYSNNS	APOBEC4	111	Q8WW27
LYRQLAHQSNSTNIF	SERPINA1	61	P01009
RHSGTYILQTFNRQL	CEACAM16	101	Q2WEN9
INHLYLLSNSSFSQG	ABCA13	1401	Q86UQ4
NRHLQTVNNYFLFSL	CHRM2	51	P08172
YSSLQLQALNHRFQQ	DLX6	56	P56179
AFNGYNHSTNRLTLA	ADAMTS15	586	Q8TE58
QLYRTLFSVINNGHN	PDS5B	156	Q9NTI5
SLQSYQLSPNRHFSL	PCDHGA7	166	Q9Y5G6
SLRSYQLSSNLHFSL	PCDHGA5	166	Q9Y5G8
NFRLLSYHVSAQNLV	AP3M2	256	P53677
LYVRLSHNSLTNNGL	FMOD	271	Q06828
IYLHKQSSSQQRRNF	METAP1D	26	Q6UB28
SRVLYHFLSSQQLEN	LLGL2	221	Q6P1M3
NHRYFATTSIVLFLN	GNAT1	251	P11488
LHSLRYLDLSNNFIS	LRRC53	156	A6NM62
AISSNRQVLHFYQRS	FANCM	611	Q8IYD8
ISNVSHNYARAVLSQ	LNX2	291	Q8N448
QLNSLFDHYSSSVIN	CCDC178	346	Q5BJE1
NLNSIFYEHLTRSLQ	PCNX1	1551	Q96RV3
SSHYRYRSSNLAQQA	MTSS1	296	O43312
RAALHLYSNTLNFQI	NAA10	116	P41227
SSYVQARNQIFSNLH	DNAH12	191	Q6ZR08
AFSHSFSRNLILTYN	KCNH1	686	O95259
LSITFRNNSHNRYTI	F13A1	536	P00488
RNNSHNRYTITAYLS	F13A1	541	P00488
TYQLSHFQSISVLGN	PLEKHM3	256	Q6ZWE6
QQSFLHTLDSYRILQ	DDB2	91	Q92466
LQNNGLLTTLSQHYF	RICTOR	646	Q6R327
LHKLSNQNNSYGTRF	NOX4	556	Q9NPH5
ILSVLNYFQNSHSVL	NPC1	481	O15118
GHDYSTAQQLLRSSN	TP73	551	O15350
FTLNHLDSRAYLNSS	MALRD1	326	Q5VYJ5
LQLNSTHFLNIYFAS	PAPPA2	676	Q9BXP8
RSTFYVLNPHNNLSS	ESPL1	1946	Q14674
ISGFQLSSHTQYRTA	GTPBP10	236	A4D1E9
SAQFRSLHQYAAQRI	DYM	471	Q7RTS9
SLHQYAAQRIISLFS	DYM	476	Q7RTS9
LNYFHLIALALRNSS	FOXR1	176	Q6PIV2
ATLNAFLYRTGQHSN	ATAD3C	256	Q5T2N8
QLSQQDHYNFGLRSL	DNAH14	1301	Q0VDD8
FSLLANQLYLHRGTQ	LYST	2376	Q99698
YGLTKNFSSLHLNSR	MAP3K20	641	Q9NYL2
NAYNTSLSLIFSRNL	ITGA10	836	O75578
EYSTHQLFSQLTLLQ	KNDC1	1466	Q76NI1
TLLNIYFRHQTLGQT	FRY	2946	Q5TBA9
HNYLQSLSTEAQALA	IKZF4	271	Q9H2S9
HFASSSLNLNSAYKL	NOCT	336	Q9UK39
IRNVAYQSTSFHNTA	FOCAD	1651	Q5VW36
VALNNFSRYFLHQSR	FTMT	106	Q8N4E7
SVLSTNQNLTHLYLR	NLRP3	906	Q96P20
LFRNHQSSYQTRLNA	PON1	16	P27169
SYNLLFQLQSSDFHS	TLR10	56	Q9BXR5
AYQHRLSETRTQFNN	SYNE1	3581	Q8NF91
NHLYNLVDLQSSFTS	TDRD15	911	B5MCY1
TNLNYATNLTHLYLQ	PPP1R42	66	Q7Z4L9
RTVESLQNSSYNHFA	SIK1B	321	A0A0B4J2F2
RTVESLQNSSYNHFA	SIK1	321	P57059
QSQTLFSQHTSRLFY	TENM1	846	Q9UKZ4
NRTASESNVYLNSFH	PHLDB2	976	Q86SQ0
IHSTLARYTQVTNFL	SLC35F4	56	A4IF30
LQRNLQFHAFISYSG	TLR1	631	Q15399
RQNLLSQSHAYQQFL	SPTBN1	1161	Q01082
NVHNLNYSSSRTLLF	ALG8	91	Q9BVK2
SSHNLQNYISSRRKS	CNK3/IPCEF1	91	G9CGD6
SSHNLQNYISSRRKS	CNKSR3	91	Q6P9H4
SHSYTNSSLNALQAL	NCOA2	526	Q15596
QSHLELINTSRNYSI	ZNF37A	76	P17032
SSNSAVALNLNLYFR	SPG11	276	Q96JI7
DTRQSYANSSSFQRH	TLR8	436	Q9NR97
LTAYLQTLHRQSLAN	VPS11	436	Q9H270
TRHFKGQAQNYSTLL	SEMA4G	46	Q9NTN9
RAFSQSSSLTQHYRF	ZNF514	351	Q96K75
STQALTYLNALQHSI	SLC12A2	761	P55011
YNLTFHSSQNVLLIT	ST14	301	Q9Y5Y6
AQQVSRFLHTYSAAT	PIGO	371	Q8TEQ8
LSSSHSYQRNDLQLR	PSMG2	121	Q969U7
FSSAAQNLRRAYSLQ	TTC16	111	Q8NEE8
SSQQVLLEHSYAFRN	THAP2	116	Q9H0W7
LFSNHFSTLVYRNLQ	TRPM8	496	Q7Z2W7
FSSSQLLRQYALSGH	ZNF169	101	Q14929