Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	1.76e-07	5	53	3	GO:0030156
GeneOntologyMolecularFunction	extracellular matrix binding	PXDN ZAN LTBP2	9.63e-04	73	53	3	GO:0050840
GeneOntologyMolecularFunction	serine-type endopeptidase activity	PREP C1S MMP3 MMP14	1.62e-03	190	53	4	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	PREP C1S MMP3 MMP14	2.21e-03	207	53	4	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	PREP C1S MMP3 MMP14	2.41e-03	212	53	4	GO:0017171
GeneOntologyMolecularFunction	retinoic acid binding	UGT2B15 UGT2B17	2.50e-03	28	53	2	GO:0001972
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	4.55e-05	28	52	3	GO:0002177
GeneOntologyCellularComponent	azurophil granule membrane	HLA-H BRI3 GAA	4.28e-04	59	52	3	GO:0035577
GeneOntologyCellularComponent	azurophil granule	HLA-H BRI3 PSMD1 GAA	6.72e-04	160	52	4	GO:0042582
GeneOntologyCellularComponent	primary lysosome	HLA-H BRI3 PSMD1 GAA	6.72e-04	160	52	4	GO:0005766
MousePheno	ectopic manchette	RIMBP3 RIMBP3C RIMBP3B	3.11e-05	19	46	3	MP:0009377
MousePheno	detached sperm flagellum	RIMBP3 RIMBP3C RIMBP3B	4.25e-05	21	46	3	MP:0008893
Domain	EGF	FAT2 ZAN CNTNAP2 C1S LTBP2	2.36e-05	126	51	5	PF00008
Domain	ANTENNAPEDIA	HOXB1 HOXB8 HOXD8	3.73e-05	24	51	3	PS00032
Domain	EGF_3	FAT2 ZAN CNTNAP2 C1S LTBP2	4.43e-04	235	51	5	PS50026
Domain	EGF-like_dom	FAT2 ZAN CNTNAP2 C1S LTBP2	5.76e-04	249	51	5	IPR000742
Domain	EGF_1	FAT2 ZAN CNTNAP2 C1S LTBP2	6.42e-04	255	51	5	PS00022
Domain	EGF-like_CS	FAT2 ZAN CNTNAP2 C1S LTBP2	7.13e-04	261	51	5	IPR013032
Domain	Pept_M10A_Zn_BS	MMP3 MMP14	7.50e-04	15	51	2	IPR021158
Domain	EGF_2	FAT2 ZAN CNTNAP2 C1S LTBP2	7.63e-04	265	51	5	PS01186
Domain	Hemopexin_CS	MMP3 MMP14	9.68e-04	17	51	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP3 MMP14	1.09e-03	18	51	2	IPR016293
Domain	SH3_9	RIMBP3 RIMBP3C RIMBP3B	1.26e-03	78	51	3	PF14604
Domain	PG_binding_1	MMP3 MMP14	1.35e-03	20	51	2	PF01471
Domain	Peptidoglycan-bd-like	MMP3 MMP14	1.35e-03	20	51	2	IPR002477
Domain	UDPGT	UGT2B15 UGT2B17	1.49e-03	21	51	2	PF00201
Domain	Homeobox_Antennapedia_CS	HOXB8 HOXD8	1.49e-03	21	51	2	IPR001827
Domain	UDPGT	UGT2B15 UGT2B17	1.49e-03	21	51	2	PS00375
Domain	UDP_glucos_trans	UGT2B15 UGT2B17	1.49e-03	21	51	2	IPR002213
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	1.67e-03	86	51	3	IPR011511
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	1.67e-03	86	51	3	PF07653
Domain	Hemopexin-like_dom	MMP3 MMP14	1.78e-03	23	51	2	IPR000585
Domain	Hemopexin-like_repeat	MMP3 MMP14	1.78e-03	23	51	2	IPR018487
Domain	M10A_MMP	MMP3 MMP14	1.78e-03	23	51	2	IPR033739
Domain	Hemopexin	MMP3 MMP14	1.78e-03	23	51	2	PF00045
Domain	HEMOPEXIN	MMP3 MMP14	1.78e-03	23	51	2	PS00024
Domain	-	MMP3 MMP14	1.78e-03	23	51	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP3 MMP14	1.78e-03	23	51	2	PS51642
Domain	HX	MMP3 MMP14	1.78e-03	23	51	2	SM00120
Domain	Pept_M10A	MMP3 MMP14	1.78e-03	23	51	2	IPR021190
Domain	Homeobox_metazoa	HOXB1 HOXB8 HOXD8	1.91e-03	90	51	3	IPR020479
Domain	Peptidase_M10	MMP3 MMP14	1.94e-03	24	51	2	PF00413
Domain	FN3	RIMBP3 EPHB6 RIMBP3C RIMBP3B	2.11e-03	199	51	4	PS50853
Domain	-	KLHL28 KLHL21	2.46e-03	27	51	2	2.130.10.80
Domain	FN3_dom	RIMBP3 EPHB6 RIMBP3C RIMBP3B	2.52e-03	209	51	4	IPR003961
Domain	ZnMc	MMP3 MMP14	2.83e-03	29	51	2	SM00235
Domain	Peptidase_Metallo	MMP3 MMP14	2.83e-03	29	51	2	IPR006026
Domain	EGF	FAT2 ZAN CNTNAP2 LTBP2	3.84e-03	235	51	4	SM00181
Domain	Gal_Oxidase_b-propeller	KLHL28 KLHL21	3.88e-03	34	51	2	IPR015916
Domain	VWFC_1	PXDN ZAN	4.34e-03	36	51	2	PS01208
Domain	EGF_CA	FAT2 C1S LTBP2	4.51e-03	122	51	3	SM00179
Domain	EGF-like_Ca-bd_dom	FAT2 C1S LTBP2	4.72e-03	124	51	3	IPR001881
Domain	VWC	PXDN ZAN	4.83e-03	38	51	2	SM00214
Domain	VWFC_2	PXDN ZAN	4.83e-03	38	51	2	PS50184
Domain	LAM_G_DOMAIN	FAT2 CNTNAP2	4.83e-03	38	51	2	PS50025
Domain	Laminin_G_2	FAT2 CNTNAP2	5.34e-03	40	51	2	PF02210
Domain	CYSTEINE_SWITCH	MMP3 MMP14	5.60e-03	41	51	2	PS00546
Domain	VWF_dom	PXDN ZAN	5.87e-03	42	51	2	IPR001007
Domain	BTB-kelch_protein	KLHL28 KLHL21	6.15e-03	43	51	2	IPR017096
Domain	Pept_M10_metallopeptidase	MMP3 MMP14	6.15e-03	43	51	2	IPR001818
Domain	SAM_2	EPHB6 SAMHD1	6.15e-03	43	51	2	PF07647
Domain	LamG	FAT2 CNTNAP2	6.43e-03	44	51	2	SM00282
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	1.41e-08	4	54	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	3.53e-08	5	54	3	17855024
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	1.27e-06	14	54	3	17662146
Pubmed	Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair.	MMP3 MMP14	2.37e-06	2	54	2	36162272
Pubmed	Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.	UGT2B15 UGT2B17	2.37e-06	2	54	2	32660355
Pubmed	The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.	UGT2B15 UGT2B17	2.37e-06	2	54	2	1909870
Pubmed	Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications.	UGT2B15 UGT2B17	2.37e-06	2	54	2	24121496
Pubmed	Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation.	UGT2B15 UGT2B17	2.37e-06	2	54	2	3117546
Pubmed	Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study.	UGT2B15 UGT2B17	2.37e-06	2	54	2	24267955
Pubmed	Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression.	UGT2B15 UGT2B17	2.37e-06	2	54	2	22170718
Pubmed	Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo.	HOXB1 HOXB8	2.37e-06	2	54	2	12835396
Pubmed	Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5.	UGT2B15 UGT2B17	2.37e-06	2	54	2	3105095
Pubmed	UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells.	UGT2B15 UGT2B17	2.37e-06	2	54	2	17848572
Pubmed	Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.	UGT2B15 UGT2B17	2.37e-06	2	54	2	27496708
Pubmed	Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.	UGT2B15 UGT2B17	2.37e-06	2	54	2	28228532
Pubmed	Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.	UGT2B15 UGT2B17	2.37e-06	2	54	2	15666817
Pubmed	The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.	UGT2B15 UGT2B17	2.37e-06	2	54	2	17698910
Pubmed	Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.	HOXB1 HOXB8 HOXD8	5.34e-06	22	54	3	26283362
Pubmed	Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.	HOXB1 HOXB8 HOXD8	6.13e-06	23	54	3	28041967
Pubmed	Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.	MMP3 MMP14	7.09e-06	3	54	2	17669621
Pubmed	Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism.	UGT2B15 UGT2B17	7.09e-06	3	54	2	19572376
Pubmed	Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines.	UGT2B15 UGT2B17	7.09e-06	3	54	2	26163549
Pubmed	Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study.	MMP3 MMP14	7.09e-06	3	54	2	37986083
Pubmed	Forkhead box protein A1 regulates UDP-glucuronosyltransferase 2B15 gene transcription in LNCaP prostate cancer cells.	UGT2B15 UGT2B17	7.09e-06	3	54	2	20736324
Pubmed	Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.	UGT2B15 UGT2B17	7.09e-06	3	54	2	26385605
Pubmed	Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study.	UGT2B15 UGT2B17	7.09e-06	3	54	2	28882566
Pubmed	Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells.	UGT2B15 UGT2B17	7.09e-06	3	54	2	17988216
Pubmed	Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes.	HOXB8 HOXD8	7.09e-06	3	54	2	11311170
Pubmed	Tissue distribution and relative gene expression of UDP-glucuronosyltransferases (2B7, 2B15, 2B17) in the human fetus.	UGT2B15 UGT2B17	7.09e-06	3	54	2	23223495
Pubmed	Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes.	UGT2B15 UGT2B17	7.09e-06	3	54	2	18302198
Pubmed	The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice.	UGT2B15 UGT2B17	7.09e-06	3	54	2	30689982
Pubmed	A pericellular collagenase directs the 3-dimensional development of white adipose tissue.	MMP3 MMP14	1.42e-05	4	54	2	16678100
Pubmed	Functional roles of MMP14 and MMP15 in early postnatal mammary gland development.	MMP3 MMP14	1.42e-05	4	54	2	27633994
Pubmed	Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis.	MMP3 MMP14	1.42e-05	4	54	2	21925226
Pubmed	Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes.	MMP3 MMP14	1.42e-05	4	54	2	11751414
Pubmed	Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice.	DMGDH ARC	1.42e-05	4	54	2	18782777
Pubmed	Calcitrol (1alpha,25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells.	UGT2B15 UGT2B17	1.42e-05	4	54	2	18281521
Pubmed	Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients.	UGT2B15 UGT2B17	1.42e-05	4	54	2	26176234
Pubmed	Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44.	MMP3 MMP14	1.42e-05	4	54	2	12727228
Pubmed	Diminished matrix metalloproteinase 2 (MMP-2) in ectomesenchyme-derived tissues of the Patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration.	MMP3 MMP14	2.36e-05	5	54	2	10433819
Pubmed	Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2.	MMP3 MMP14	2.36e-05	5	54	2	8804434
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	PXDN PREP MKRN1 CNTNAP2 HLA-H GAA	2.37e-05	371	54	6	15747579
Pubmed	Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.	LTBP2 MMP3 MMP14	2.44e-05	36	54	3	20587546
Pubmed	Atlas of Hox gene expression in the developing kidney.	HOXB1 HOXB8 HOXD8	2.87e-05	38	54	3	15042701
Pubmed	Complete mutation analysis panel of the 39 human HOX genes.	HOXB1 HOXB8 HOXD8	2.87e-05	38	54	3	11857506
Pubmed	Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.	HOXB1 HOXB8 HOXD8	3.11e-05	39	54	3	33257809
Pubmed	Quantification of Hox and surfactant protein-B transcription during murine lung development.	HOXB1 HOXB8 HOXD8	3.36e-05	40	54	3	19204410
Pubmed	In vivo mutagenesis of the Hoxb8 hexapeptide domain leads to dominant homeotic transformations that mimic the loss-of-function mutations in genes of the Hoxb cluster.	HOXB8 HOXD8	3.54e-05	6	54	2	14623233
Pubmed	Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs.	MMP3 MMP14	3.54e-05	6	54	2	30269950
Pubmed	Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.	MMP3 MMP14	3.54e-05	6	54	2	10947989
Pubmed	Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer.	UGT2B15 UGT2B17	3.54e-05	6	54	2	21365123
Pubmed	Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.	MMP3 MMP14	3.54e-05	6	54	2	7998967
Pubmed	Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.	MMP3 MMP14	3.54e-05	6	54	2	15863497
Pubmed	ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.	MMP3 MMP14	3.54e-05	6	54	2	12054629
Pubmed	Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates.	HOXB1 HOXB8 HOXD8	3.62e-05	41	54	3	32479258
Pubmed	Reduction of Hox gene expression by histone H1 depletion.	HOXB1 HOXB8 HOXD8	4.18e-05	43	54	3	22701719
Pubmed	Nomenclature for human homeobox genes.	HOXB1 HOXB8 HOXD8	4.48e-05	44	54	3	1973146
Pubmed	Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.	MMP3 MMP14	4.94e-05	7	54	2	8216228
Pubmed	Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).	MMP3 MMP14	4.94e-05	7	54	2	10922468
Pubmed	Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins.	MMP3 MMP14	4.94e-05	7	54	2	12810672
Pubmed	Developmental regulation of the Hox genes during axial morphogenesis in the mouse.	HOXB1 HOXB8	4.94e-05	7	54	2	15944185
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B15 UGT2B17	4.94e-05	7	54	2	26074487
Pubmed	Vertebrate homeobox gene nomenclature.	HOXB1 HOXB8 HOXD8	5.47e-05	47	54	3	1358459
Pubmed	New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.	HOXB1 HOXB8 HOXD8	6.59e-05	50	54	3	28188179
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B15 UGT2B17	6.59e-05	8	54	2	32093886
Pubmed	Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.	MMP3 MMP14	6.59e-05	8	54	2	11865039
Pubmed	Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry.	UGT2B15 UGT2B17	6.59e-05	8	54	2	22579593
Pubmed	Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney.	SOX8 SLC5A2	6.59e-05	8	54	2	26279573
Pubmed	The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.	UGT2B15 UGT2B17	6.59e-05	8	54	2	18719240
Pubmed	Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.	UGT2B15 UGT2B17	6.59e-05	8	54	2	20142249
Pubmed	Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.	SRRT MKRN1 FAM98A	7.41e-05	52	54	3	26265008
Pubmed	The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.	HOXB1 HOXD8	8.46e-05	9	54	2	7913891
Pubmed	Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.	HOXB1 PREP	8.46e-05	9	54	2	20195514
Pubmed	A yeast artificial chromosome containing the mouse homeobox cluster Hox-2.	HOXB1 HOXB8	8.46e-05	9	54	2	1972280
Pubmed	HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation.	HOXB1 HOXD8	8.46e-05	9	54	2	8890171
Pubmed	Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain.	HOXB1 HOXB8	1.06e-04	10	54	2	2571936
Pubmed	TGF-beta3-induced palatogenesis requires matrix metalloproteinases.	MMP3 MMP14	1.29e-04	11	54	2	11359935
Pubmed	A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations.	HOXB1 HOXB8	1.29e-04	11	54	2	10885747
Pubmed	Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.	UGT2B15 UGT2B17	1.55e-04	12	54	2	20308471
Pubmed	Expression of class I homeobox genes in fetal and adult murine skin.	HOXB1 HOXB8	1.55e-04	12	54	2	8105001
Pubmed	Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.	MMP3 MMP14	1.55e-04	12	54	2	12149192
Pubmed	Assignment of the mouse ataxia-telangiectasia gene (Atm) to mouse chromosome 9.	LIPC MMP3	1.55e-04	12	54	2	8672141
Pubmed	Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development.	MMP3 MMP14	1.83e-04	13	54	2	12815621
Pubmed	Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development.	HOXB1 HOXB8	1.83e-04	13	54	2	24525295
Pubmed	Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.	SRRT ZAN	1.83e-04	13	54	2	11239002
Pubmed	Hox-1.11 and Hox-4.9 homeobox genes.	HOXB1 HOXD8	2.13e-04	14	54	2	1348361
Pubmed	Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice.	HOXB1 HOXB8	2.13e-04	14	54	2	12753872
Pubmed	A distinct Hox code for the branchial region of the vertebrate head.	HOXB1 HOXB8	2.45e-04	15	54	2	1682814
Pubmed	uPARAP expression during murine lung development.	MMP3 MMP14	2.45e-04	15	54	2	18639653
Pubmed	Cdx2 is essential for axial elongation in mouse development.	HOXB1 HOXB8	2.45e-04	15	54	2	15136723
Pubmed	Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).	LIPC MMP3	2.45e-04	15	54	2	20385826
Pubmed	Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.	MMP3 MMP14	2.80e-04	16	54	2	20484597
Pubmed	Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.	HOXB1 SOX8	2.80e-04	16	54	2	19527706
Pubmed	Matrix metalloproteinases in tumor invasion.	MMP3 MMP14	2.80e-04	16	54	2	10949577
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP3 MMP14	2.80e-04	16	54	2	37701782
Pubmed	Hox genes and the evolution of vertebrate axial morphology.	HOXB8 HOXD8	2.80e-04	16	54	2	7768176
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KLHL21 ARC PFAS GRIN2D MMP14 UVRAG SMURF2 PRRT4	2.88e-04	1105	54	8	35748872
Pubmed	Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation.	HOXB1 HOXB8	3.56e-04	18	54	2	9291463
Pubmed	ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.	MMP3 MMP14	3.98e-04	19	54	2	22014525
Pubmed	Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.	HOXB1 LTBP2	4.42e-04	20	54	2	25190705
Cytoband	4q13	UGT2B15 UGT2B17	1.41e-04	15	54	2	4q13
Cytoband	17q21.3	HOXB1 HOXB8	1.61e-04	16	54	2	17q21.3
Cytoband	22q11.21	RIMBP3 RIMBP3C RIMBP3B	3.12e-04	111	54	3	22q11.21
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	SRRT ZAN NAT16	2.22e-03	219	54	3	chr7q22
GeneFamily	HOXL subclass homeoboxes	HOXB1 HOXB8 HOXD8	1.26e-04	52	34	3	518
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP3 MMP14	9.23e-04	24	34	2	891
GeneFamily	UDP glucuronosyltransferases	UGT2B15 UGT2B17	1.64e-03	32	34	2	363
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	UVRAG SMURF2	2.08e-03	36	34	2	823
GeneFamily	Kelch like\|BTB domain containing	KLHL28 KLHL21	2.82e-03	42	34	2	617
GeneFamily	Sterile alpha motif domain containing	EPHB6 SAMHD1	1.19e-02	88	34	2	760
Coexpression	DESCARTES_ORGANOGENESIS_HEPATOCYTES	DMGDH LIPC ZAN HLA-H UGT2B15 UGT2B17 C1S ALS2CL	9.77e-06	535	52	8	MM3635
Coexpression	GSE24634_NAIVE_CD4_TCELL_VS_DAY7_IL4_CONV_TREG_UP	KLHL28 KLHL21 SAMHD1 UVRAG SMURF2	4.78e-05	200	52	5	M4590
Coexpression	GSE17186_MEMORY_VS_NAIVE_BCELL_DN	DLGAP4 MKRN1 LTBP2 ALS2CL TMBIM1	4.78e-05	200	52	5	M7171
Coexpression	GSE34156_NOD2_LIGAND_VS_NOD2_AND_TLR1_TLR2_LIGAND_6H_TREATED_MONOCYTE_DN	KLHL21 DLGAP4 PSMD1 FAM98A HAL	4.78e-05	200	52	5	M8688
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB1 MAP4K3 MKRN1 SAMHD1 ALS2CL	1.92e-06	169	54	5	4e1322cc5e1733e9fb19e08f739a30206f43cea8
ToppCell	wk_15-18-Mesenchymal-Fibroblast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PXDN CNTNAP2 ITGA8 C1S MMP14	4.37e-06	200	54	5	4f624c3c57d1a84baa86d0830cb1b83ae110bf67
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LHFPL4 NAT16 ITGA8 GRIN2D	4.24e-05	160	54	4	830e3ef8c9708d25872c3052a0b2682fa9372111
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	HOXB1 LHFPL4 ITGA8 PPM1K	4.67e-05	164	54	4	519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell	Posterior_cortex-Neuronal-Inhibitory\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CNTNAP2 GRIN2D PRRT4 GAA	5.01e-05	167	54	4	9a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN CNTNAP2 LTBP2 MMP3	5.25e-05	169	54	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARC RIMBP3C SAMHD1 SOX8	5.88e-05	174	54	4	c9d4e375dedd2b099a9ed70ec38ff35bbb0ce48a
ToppCell	5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARC RIMBP3C SAMHD1 SOX8	5.88e-05	174	54	4	1463c98f8f519dd030587abbdbeb1b4e1bca5dd1
ToppCell	5'-GW_trimst-2-LymphNode-Neuronal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARC RIMBP3C SAMHD1 SOX8	5.88e-05	174	54	4	d421c0069d24cb560a3a429929e3cd1eceaeabcf
ToppCell	AT1-AT2_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	PXDN CNTNAP2 UGT2B15 OVOS2	6.14e-05	176	54	4	f86832cfeff5b3cfffe4455c1b96a1420d48ba1e
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB6 ZAN C1S HAL	6.42e-05	178	54	4	c77a1d1a9aef0ab51b4408b9e84f201219788ca2
ToppCell	390C-Fibroblasts-Fibroblast-G\|390C / Donor, Lineage, Cell class and subclass (all cells)	ITGA8 C1S LTBP2 MMP3	6.70e-05	180	54	4	137fc14859c89e1ecd98bee388bb58c04b835847
ToppCell	390C-Fibroblasts-Fibroblast-G-\|390C / Donor, Lineage, Cell class and subclass (all cells)	ITGA8 C1S LTBP2 MMP3	6.70e-05	180	54	4	cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCell	droplet-Lung-nan-21m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB6 HOXB8 LHFPL4 SOX8	7.15e-05	183	54	4	19e7be1cfdd111bfb840532a6f7c780345dffccf
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-H OVOS2 GRIN2D PRRT4	7.15e-05	183	54	4	e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCell	droplet-Lung-nan-21m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB6 HOXB8 LHFPL4 SOX8	7.15e-05	183	54	4	b153425ab0df1e5fa9b953e1f6d4e8e3dc6621b0
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITGA8 ARC C1S MMP3	7.30e-05	184	54	4	e33e2a887aafba7b6a31f00bb0dbe974b4359fd6
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA8 C1S LTBP2 MMP14	7.45e-05	185	54	4	87c416d14ca6255bee39b16e7571553e36ee3069
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXB8 ITGA8 C1S MMP3	7.45e-05	185	54	4	355b03c7ea438681e11a2b872c798c9ea26e1486
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CNTNAP2 ITGA8 LTBP2 MMP14	7.61e-05	186	54	4	4e983de6d2515082f9e555f4f949cec84281c140
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CNTNAP2 UGT2B17 PPM1K UVRAG	8.26e-05	190	54	4	a7498fe55b7810c482291db782dc5282675d246a
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA8 C1S LTBP2 MMP14	8.43e-05	191	54	4	0fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA8 C1S LTBP2 MMP14	8.60e-05	192	54	4	b9e4585bea280ca0ae159f0c6a2bf7b88a15a6e6
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA8 C1S LTBP2 MMP14	8.78e-05	193	54	4	b05361ffe111a38cfa26eb86e4ae62c15ac99b7b
ToppCell	Monocytes-M2-like_CD16+_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	LTBP2 MMP14 ALS2CL GAA	9.13e-05	195	54	4	10fa47bdcf6c9784ea930b75a5861e139421feed
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CNTNAP2 C1S LTBP2 MMP14	9.50e-05	197	54	4	b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CNTNAP2 C1S LTBP2 MMP14	9.50e-05	197	54	4	5afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CNTNAP2 C1S LTBP2 MMP14	9.50e-05	197	54	4	1baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA8 C1S MMP3 MMP14	9.50e-05	197	54	4	cfd4cc5fb8d7a60dd5c0d2a1a7bad7ba38c19d40
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-G\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	ITGA8 C1S LTBP2 PPM1K	9.50e-05	197	54	4	a21a710c824f9e5c7ef1674168d1ce5aef85bd35
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PXDN MAP4K3 ITGA8 C1S	9.69e-05	198	54	4	09be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ITGA8 C1S LTBP2 MMP14	9.69e-05	198	54	4	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PXDN ITGA8 C1S MMP14	9.69e-05	198	54	4	ebceb11f50b8a6ebb7629fdbd3d31fb131ace6fd
ToppCell	Epithelial_cells-Basal_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	FAT2 LTBP2 MMP3 MMP14	9.69e-05	198	54	4	4235005c49fc2b29ad3a0ee6b608f0109d04f775
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C1S LTBP2 MMP3 MMP14	9.69e-05	198	54	4	229588189825b1080181db9515185677b742c668
ToppCell	10x5'v1-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CNTNAP2 C1S LTBP2 MMP14	9.88e-05	199	54	4	6200618e029063486719479c41eaf31798bd13cf
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA8 C1S LTBP2 MMP3	9.88e-05	199	54	4	e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCell	10x5'v1-week_14-16-Mesenchymal_adipo-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CNTNAP2 C1S LTBP2 MMP14	9.88e-05	199	54	4	9b2262edbdec89166d895ab97527e0ee5f9b6010
ToppCell	10x5'v1-week_14-16-Mesenchymal_adipo\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CNTNAP2 C1S LTBP2 MMP14	9.88e-05	199	54	4	251b3643dcd8f4645b17101bd716e66f12a20e88
ToppCell	10x5'v1-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CNTNAP2 C1S LTBP2 MMP14	9.88e-05	199	54	4	117f4f43b6c06dda553799b1063e827bce697370
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA8 C1S SAMHD1 LTBP2	1.01e-04	200	54	4	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA8 C1S SAMHD1 LTBP2	1.01e-04	200	54	4	3dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA8 C1S SAMHD1 LTBP2	1.01e-04	200	54	4	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	wk_15-18-Mesenchymal\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PXDN ITGA8 C1S MMP14	1.01e-04	200	54	4	4d484260ecbbbd9f820b445bdcc2666f6c464b73
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PXDN C1S MMP3 MMP14	1.01e-04	200	54	4	0655328373d1b58828e141ddb0dcbb2cce10dc50
ToppCell	wk_15-18-Mesenchymal-Fibroblast-intermediate_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PXDN CNTNAP2 C1S MMP14	1.01e-04	200	54	4	6461d25fd8fb52921b188f083fbe808535d3130b
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PXDN ITGA8 C1S MMP14	1.01e-04	200	54	4	ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Cribiform_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	HOXB8 UGT2B17 SLC5A2	1.35e-04	82	54	3	6d8a4ae3988b1e2ac1951e7d490c334d727e9c5b
ToppCell	facs-Skin-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRI3 LTBP2 GRIN2D	1.84e-04	91	54	3	48a2c7c4ce9d23762b314e7d2537b3bb38ce6c8e
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB1 C1S GRIN2D	5.25e-04	130	54	3	e5acaa9aaa22b10d11410e2c01647b31354c21ed
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HOXB1 LIPC ARC	6.12e-04	137	54	3	48c21e6938a46e3cd74ac10b8ace0a4751741af7
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB1 C1S GRIN2D	6.25e-04	138	54	3	d5342383c5e52b92c39d7afe76560501be3ea5cd
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB1 C1S GRIN2D	6.25e-04	138	54	3	e2659949944bdf39b23c7275e380a7a937e2726c
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PXDN C1S ALS2CL	6.51e-04	140	54	3	0e1e9281de87df178ac41ed6b697b4fa09be2749
ToppCell	remission-multiplets\|World / disease stage, cell group and cell class	ARC SOX8 PRRT4	6.79e-04	142	54	3	286d01b4f95e9c0b38b91958f925f3797dffd596
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LHFPL4 MMP3 SOX8	6.79e-04	142	54	3	819e983688d126d89a71abc03d72525cc759a347
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	UGT2B15 HAL MMP14	7.80e-04	149	54	3	13b445c13bb8f31ff0876addd1baf969ae220ea3
ToppCell	remission-multiplets\|remission / disease stage, cell group and cell class	ARC SOX8 PRRT4	7.80e-04	149	54	3	e9974260a5f2999b363f306cae005698c912893a
ToppCell	PND01-03-samps-Mesenchymal-Pericyte\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ZAN C1S LTBP2	8.26e-04	152	54	3	fc9472bc19f997103da535b035105f01429cb08e
ToppCell	COVID-CD4-antiviral_CD4\|COVID / Condition, Cell_class and T cell subcluster	SOX8 PPM1K SLC5A2	8.74e-04	155	54	3	7e5ae034036fe85915d38a24195501e6d3bcbfb0
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMGDH LIPC C1S	8.91e-04	156	54	3	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	Basal_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	FAT2 LHFPL4 CNTNAP2	9.24e-04	158	54	3	51e3ed1b91b010404d66e3e7efdbffc0c815e25b
ToppCell	390C-Epithelial_cells-Epithelial-H_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	FAT2 CNTNAP2 MMP3	9.58e-04	160	54	3	830f17bad94de05612fe6d53d39e42a4b3f3e2f3
ToppCell	390C-Epithelial_cells-Epithelial-H_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FAT2 CNTNAP2 MMP3	9.58e-04	160	54	3	18ae6822915d16699beb9047baeef9b006901a35
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB8 HOXD8 BRI3	9.76e-04	161	54	3	9edcab51da01a84cfe6166ed4c1f951a4ceeac55
ToppCell	facs-Large_Intestine-Proximal-24m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB8 HOXD8 BRI3	9.76e-04	161	54	3	cb4921da94b3355d5234b389aa3ec15939607cd5
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HOXD8 MAP4K3 LTBP2	9.93e-04	162	54	3	36ddebe3bb172c992739353b7b049b2dde98b559
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXB8 ANO7 SOX8	9.93e-04	162	54	3	ded08da888d8c481f0f96d1e0bfd03d617966910
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CNTNAP2 C1S PPM1K	1.01e-03	163	54	3	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	droplet-Liver-Hepatocytes-21m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMGDH LIPC HAL	1.03e-03	164	54	3	c9866a289e120be4066e66275c3beb97ba67cca4
ToppCell	droplet-Liver-Hepatocytes-21m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMGDH C1S HAL	1.03e-03	164	54	3	90afae3cca108ebfb44ff2ec4adcbb8c68a0bdf2
ToppCell	NS-critical-d_0-4-Epithelial-unknown_epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAT2 ARC ALS2CL	1.07e-03	166	54	3	dd02bbe4af609c6348dc92417254f4740f2900a8
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EPHB6 PTCHD3 C1S	1.07e-03	166	54	3	545f6c91102568791443717e522f89cb3bd1a070
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-7\|TCGA-Thryoid / Sample_Type by Project: Shred V9	LIPC NAT16 GAA	1.08e-03	167	54	3	01c42e555913b17e62846325cc17b3d8f92da1e1
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	ITGA8 C1S LTBP2	1.08e-03	167	54	3	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	367C-Fibroblasts-Fibroblast-G-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ITGA8 C1S LTBP2	1.10e-03	168	54	3	b8c65542a0701ae31f49d332d87a64578e24b4e3
ToppCell	367C-Fibroblasts-Fibroblast-G\|367C / Donor, Lineage, Cell class and subclass (all cells)	ITGA8 C1S LTBP2	1.10e-03	168	54	3	8c95093b1ea45826f62893edd3c410fe53b563a4
ToppCell	Endothelial-B-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	LIPC PTCHD3 HOXD8	1.10e-03	168	54	3	4977c3837fbb1f36c89fddd5764e37290ac25ad8
ToppCell	-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	ITGA8 C1S LTBP2	1.12e-03	169	54	3	8ebe9a88111c53a09c25a7b6a164a0a17880458d
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil-promyelocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	EPHB6 ANO7 SMURF2	1.12e-03	169	54	3	f33f4a0baad1b3cb5be61dfc7b00c7a3845f7120
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CNTNAP2 GRIN2D GAA	1.12e-03	169	54	3	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LHFPL4 ITGA8 PPM1K	1.12e-03	169	54	3	563c267edaade0e5df192ad953801ef9768d4270
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PXDN C1S SAMHD1	1.12e-03	169	54	3	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C1S MMP3 MMP14	1.12e-03	169	54	3	031465190cd3623a25ef2b868daab8d932c8ff08
ToppCell	droplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPC LHFPL4 ITGA8	1.14e-03	170	54	3	29deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCell	droplet-Thymus-nan-21m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPC LHFPL4 ITGA8	1.14e-03	170	54	3	dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCell	ICU-SEP-Myeloid-pDC\|ICU-SEP / Disease, Lineage and Cell Type	ZAN OVOS2 PPM1K	1.16e-03	171	54	3	72c448a0dc4c569bd6b465f9aa395f38034e7ea6
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C1S MMP3 MMP14	1.16e-03	171	54	3	15cb4670ff4234ac46aea8a5911138d6913c4482
ToppCell	droplet-Thymus-nan-21m-Myeloid-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPC LHFPL4 ITGA8	1.16e-03	171	54	3	8bed33f61f7d12a1ac4fba33f730d839f5ee7bef
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1_VIP_PCDH20\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RIMBP3 GRIN2D RIMBP3B	1.18e-03	172	54	3	35e961c88bfe79046533396912cedf00ca81db7b
ToppCell	390C-Epithelial_cells-Epithelial-H_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FAT2 CNTNAP2 MMP3	1.18e-03	172	54	3	bb542f6ca4eb8167129bc84ca1160a54fbb68731
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PTCHD3 CNTNAP2 C1S	1.18e-03	172	54	3	9a256db817c1af1802203cc88a55d608fb328c63
ToppCell	390C-Epithelial_cells-Epithelial-H_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FAT2 CNTNAP2 MMP3	1.18e-03	172	54	3	aff37b9689b0d30ee7097d997d9588efc475c8fd
ToppCell	Endothelial-Endothelial-G\|Endothelial / shred on cell class and cell subclass (v4)	HOXD8 ITGA8 MMP14	1.18e-03	172	54	3	644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|356C / Donor, Lineage, Cell class and subclass (all cells)	EPHB6 DMGDH KLHL28	1.20e-03	173	54	3	e3cb7c8c09f937da6b8d673e9adfec5d94a15548
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ITGA8 LTBP2 MMP3	1.20e-03	173	54	3	1f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage\|368C / Donor, Lineage, Cell class and subclass (all cells)	BRI3 SAMHD1 GAA	1.20e-03	173	54	3	bba8265a58f8f5659dc7b9da2fe27b15033fce34
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC1\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAT2 SAMHD1 UVRAG	1.20e-03	173	54	3	d13ae4046a25ee0fb492ddedf44583a879a432e9
ToppCell	Endothelial-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	PTCHD3 HOXD8 OVOS2	1.20e-03	173	54	3	a81992965137195d20fc498f750975303961a828
ToppCell	-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	ITGA8 C1S LTBP2	1.20e-03	173	54	3	88be9182fbb1bc83531cd41e59ea57c112a21d54
Computational	Catabolic peptidases.	LIPC C1S MMP3 MMP14	1.89e-04	89	35	4	MODULE_209
Computational	Genes in the cancer module 172.	LIPC C1S MMP3 MMP14	2.53e-04	96	35	4	MODULE_172
Disease	cholic acid glucuronide measurement	UGT2B15 UGT2B17	7.77e-06	3	48	2	EFO_0800574
Disease	X-25937 measurement	UGT2B15 UGT2B17	1.55e-05	4	48	2	EFO_0800937
Disease	X-24574 measurement	UGT2B15 UGT2B17	5.41e-05	7	48	2	EFO_0800897
Disease	deoxycholic acid glucuronide measurement	UGT2B15 UGT2B17	7.21e-05	8	48	2	EFO_0800575
Disease	omega-6:omega-3 polyunsaturated fatty acid ratio	LIPC UGT2B15 UGT2B17	7.50e-05	50	48	3	EFO_0010732
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	DMGDH LIPC CNTNAP2 UGT2B15 UVRAG	8.22e-05	274	48	5	EFO_0004530, EFO_0004612
Disease	4-androsten-3alpha,17alpha-diol monosulfate (3) measurement	UGT2B15 UGT2B17	1.16e-04	10	48	2	EFO_0022090
Disease	DNA repair protein RAD51 homolog 4 measurement	UGT2B15 UGT2B17	1.41e-04	11	48	2	EFO_0801531
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	UGT2B15 UGT2B17	1.69e-04	12	48	2	EFO_0800291
Disease	high density lipoprotein particle size measurement	LIPC UGT2B15 UGT2B17 UVRAG	1.70e-04	170	48	4	EFO_0008592
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	UGT2B15 UGT2B17	2.00e-04	13	48	2	EFO_0800293
Disease	X-19141 measurement	UGT2B15 UGT2B17	2.00e-04	13	48	2	EFO_0800799
Disease	level of Phosphatidylethanolamine (18:1_18:1) in blood serum	LIPC CNTNAP2	2.33e-04	14	48	2	OBA_2045142
Disease	abdominal aortic aneurysm (biomarker_via_orthology)	MMP3 MMP14	2.33e-04	14	48	2	DOID:7693 (biomarker_via_orthology)
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	UGT2B15 UGT2B17	2.33e-04	14	48	2	EFO_0800283
Disease	metabolite measurement	DMGDH LIPC NAT16 UGT2B15 UGT2B17 UVRAG	2.84e-04	560	48	6	EFO_0004725
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	UGT2B15 UGT2B17	3.90e-04	18	48	2	EFO_0800288
Disease	etiocholanolone glucuronide measurement	UGT2B15 UGT2B17	4.35e-04	19	48	2	EFO_0800362
Disease	androsterone glucuronide measurement	UGT2B15 UGT2B17	4.83e-04	20	48	2	EFO_0800317
Disease	esophagus adenocarcinoma (is_implicated_in)	MMP3 MMP14	5.34e-04	21	48	2	DOID:4914 (is_implicated_in)
Disease	X-24947 measurement	UGT2B15 UGT2B17	5.86e-04	22	48	2	EFO_0800910
Disease	cotinine measurement	CNTNAP2 UGT2B15	6.41e-04	23	48	2	EFO_0007813
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	DMGDH LIPC UGT2B15 UGT2B17	6.57e-04	243	48	4	EFO_0004612, EFO_0020944
Disease	fatty acid measurement	DMGDH LIPC UGT2B15 UGT2B17 UVRAG	6.99e-04	436	48	5	EFO_0005110
Disease	epiandrosterone sulfate measurement	UGT2B15 UGT2B17	7.59e-04	25	48	2	EFO_0021120
Disease	omega-3 polyunsaturated fatty acid measurement	LIPC UGT2B15 UGT2B17	9.46e-04	118	48	3	EFO_0010119
Disease	non-high density lipoprotein cholesterol measurement	LIPC HLA-H UGT2B15 BRI3 UGT2B17 TMBIM1	1.01e-03	713	48	6	EFO_0005689
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	DMGDH LIPC UGT2B15 UGT2B17	1.05e-03	276	48	4	EFO_0004612, EFO_0020943
Disease	docosahexaenoic acid measurement	LIPC UGT2B15 UGT2B17	1.17e-03	127	48	3	EFO_0007761
Disease	alkaline phosphatase measurement	SRRT LIPC UGT2B15 BRI3 UGT2B17 LTBP2 TMBIM1	1.20e-03	1015	48	7	EFO_0004533
Disease	androsterone sulfate measurement	UGT2B15 UGT2B17	1.32e-03	33	48	2	EFO_0021117
Disease	anti-GAD65 autoimmune neurological syndromes	SRRT ZAN	1.49e-03	35	48	2	EFO_0803379
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	DMGDH LIPC UGT2B15 UGT2B17	1.56e-03	307	48	4	EFO_0004612, EFO_0020946

Protein segments in the cluster

Peptide	Gene	Start	Entry
VYKGYFQEGLRHGFG	ALS2CL	431	Q60I27
LEAGQGDYACGPHGY	BRI3	16	O95415
GDYACGPHGYGAIPA	BRI3	21	O95415
GVGGPESYCHEADGY	ARC	151	Q7LC44
GLAYHYLQVPGGGGE	DLGAP4	326	Q9Y2H0
PFDGEGGFLAHAYFP	MMP14	191	P50281
LYFAVYDGHGGPAAA	PPM1K	121	Q8N3J5
DQGFYYGELGGHRGL	RIMBP3B	1611	A6NNM3
DQGFYYGELGGHRGL	RIMBP3C	1611	A6NJZ7
GPFLRGYEQHAYDGK	HLA-H	131	P01893
GRFVGYPGNYHTLFG	ANO7	611	Q6IWH7
QLEYGQGHQGGYFLG	MAP4K3	376	Q8IVH8
AHKGLYCQGGPDFYG	DUSP13	71	Q6B8I1
NYGPGHGYDGEERAV	TMBIM1	66	Q969X1
QEYFHPGGGSPAAAY	HOXD8	91	P13378
FYPFDGPGNVLAHAY	MMP3	171	P08254
YYHSQFRQGGGGPCL	FAT2	4276	Q9NYQ8
GYHFLVGQDGGVYEG	PGLYRP3	241	Q96LB9
GGIYGGLDYLPSRYH	NAT16	71	Q8N8M0
QPIGHYDFYPNGGSF	LIPC	236	P11150
EPYGYFYHGLNLDDG	OVOS2	606	Q6IE36
PGYFGLFHYCVGSGL	LHFPL4	56	Q7Z7J7
GPKGSYFGYAVDFHI	ITGA8	51	P53708
VACHGDPGNFYGYDP	HOXB8	76	P17481
KLDGSHPAFLYGYGG	PREP	461	P48147
HPAFLYGYGGFNISI	PREP	466	P48147
FNFHINYGDLGFLGP	HYOU1	491	Q9Y4L1
GDGGYFHPSSYGAQL	HOXB1	106	P14653
GGNFHGEYPAKALDY	HAL	441	P42357
YLAEFPDHLGGGYSI	KLHL21	316	Q9UJP4
LDGMIYAIGGYGPAH	KLHL28	431	Q9NXS3
AGTEKHPGYALEYGG	CPHXL2	191	A0A1W2PPK0
VAGDRQFGPYCGHGF	C1S	241	P09871
HGGYYGDGLNAIVVF	BNIP2	156	Q12982
LYGSHPFYLALEDGG	GAA	291	P10253
EAGVHFRPGYEYGPG	LTBP2	1646	Q14767
GFGYGIIHAGGVGKY	DMGDH	396	Q9UI17
ANEKHYYWGGSGPGI	CNTNAP2	711	Q9UHC6
GRHPLYLTGFFGGYI	PTCHD3	291	Q3KNS1
PFGGNCFYKHAYPDG	MKRN1	381	Q9UHC7
GLNDGYYGAPFEHKG	UVRAG	156	Q9P2Y5
GGGYYVFPGASHNRF	SAMHD1	151	Q9Y3Z3
DQGFYYGELGGHRGL	RIMBP3	1611	Q9UFD9
DGGYRDSGFQPGGYH	FAM98A	396	Q8NCA5
AGHGPYGGKVYFQTL	EPHB6	566	O15197
AYQEGGGLYALGLIH	PSMD1	436	Q99460
QAYGGAYFHAGASPV	SOX8	301	P57073
HAPYGAGRGNYDAFR	SRRT	826	Q9BXP5
HGHYIDGGFTLPFYK	SMURF2	496	Q9HAU4
HEVGGYSGLFDKYLG	SLC5A2	221	P31639
GTAGYCFGNLHIPGY	PFAS	346	O15067
TLGEYHGYDPGINAG	PXDN	1046	Q92626
GYEVLHALGYGGQSG	PRRT4	576	C9JH25
GGTNGIYEAIYHGIP	UGT2B15	376	P54855
GGTNGIYEAIYHGIP	UGT2B17	376	O75795
GGFPNAGGHYIYLEA	ZAN	411	Q9Y493
PPGGAGLADGFHRYY	GRIN2D	951	O15399