Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	abnormal lactation	FOXB1 BIRC8 LPA PLG PRLR	7.46e-06	72	53	5	MP:0001882
MousePheno	abnormal mammary gland connective tissue morphology	LPA PLG	1.41e-05	2	53	2	MP:0009507
MousePheno	esophageal ulcer	LPA PLG	1.41e-05	2	53	2	MP:0004547
MousePheno	duodenal ulcer	LPA PLG	1.41e-05	2	53	2	MP:0003273
MousePheno	perianal ulcer	LPA PLG	1.41e-05	2	53	2	MP:0005035
MousePheno	ectropion	LPA PLG	1.41e-05	2	53	2	MP:0006164
MousePheno	abnormal mammary gland physiology	FOXB1 BIRC8 LPA PLG PRLR	1.99e-05	88	53	5	MP:0001881
MousePheno	abnormal apocrine gland physiology	FOXB1 BIRC8 LPA PLG PRLR	1.99e-05	88	53	5	MP:0013555
MousePheno	straub tail	PSAP MYO7A	4.22e-05	3	53	2	MP:0003382
MousePheno	absent cornea epithelium	LPA PLG	4.22e-05	3	53	2	MP:0020856
MousePheno	increased circulating fibrinogen level	LPA PLG	8.42e-05	4	53	2	MP:0012331
MousePheno	proctitis	LPA PLG	8.42e-05	4	53	2	MP:0003305
MousePheno	gastric ulcer	LPA PLG	2.10e-04	6	53	2	MP:0003282
MousePheno	increased acute phase protein level	LPA PLG	2.93e-04	7	53	2	MP:0014499
MousePheno	abnormal conjunctival epithelium morphology	LPA PLG	2.93e-04	7	53	2	MP:0004481
MousePheno	venoocclusion	LPA PLG	2.93e-04	7	53	2	MP:0006137
MousePheno	peptic ulcer	LPA PLG	2.93e-04	7	53	2	MP:0003301
MousePheno	decreased keratinocyte migration	LPA PLG	3.89e-04	8	53	2	MP:0012194
MousePheno	abnormal circulating fibrinogen level	LPA PLG	3.89e-04	8	53	2	MP:0010213
MousePheno	abnormal cornea stroma morphology	PSAP LPA PLG	3.95e-04	38	53	3	MP:0005300
MousePheno	abnormal skin adnexa physiology	FOXB1 BIRC8 LPA PLG PRLR	4.14e-04	167	53	5	MP:0010680
MousePheno	abnormal cerebellum anterior vermis morphology	FOXB1 WNT1	4.99e-04	9	53	2	MP:0000867
MousePheno	abnormal cerebellum anterior lobe morphology	FOXB1 WNT1	6.22e-04	10	53	2	MP:0009960
MousePheno	decreased susceptibility to induced choroidal neovascularization	LPA PLG	6.22e-04	10	53	2	MP:0003434
MousePheno	abnormal kidney thrombosis	LPA PLG	6.22e-04	10	53	2	MP:0011507
MousePheno	abnormal cochlear OHC efferent innervation pattern	PSAP MYO7A	6.22e-04	10	53	2	MP:0004632
MousePheno	abnormal keratinocyte migration	LPA PLG	7.59e-04	11	53	2	MP:0012192
MousePheno	cornea vascularization	FBN2 LPA PLG	8.38e-04	49	53	3	MP:0005542
MousePheno	abnormal exocrine gland physiology	FOXB1 BIRC8 LPA PLG PRLR	8.56e-04	196	53	5	MP:0013559
MousePheno	abnormal mammary gland morphology	FOXB1 BIRC8 LPA PLG PRLR	9.58e-04	201	53	5	MP:0000627
MousePheno	abnormal apocrine gland morphology	FOXB1 BIRC8 LPA PLG PRLR	9.58e-04	201	53	5	MP:0013554
MousePheno	abnormal anus morphology	LPA PLG	1.07e-03	13	53	2	MP:0005034
MousePheno	abnormal conjunctiva morphology	LPA PLG	1.07e-03	13	53	2	MP:0001310
Domain	EGF_CA	CD93 FBN2 VWCE SVEP1	2.03e-04	86	63	4	PF07645
Domain	EGF_Ca-bd_CS	CD93 FBN2 VWCE SVEP1	3.22e-04	97	63	4	IPR018097
Domain	EGF_CA	CD93 FBN2 VWCE SVEP1	3.48e-04	99	63	4	PS01187
Domain	ASX_HYDROXYL	CD93 FBN2 VWCE SVEP1	3.62e-04	100	63	4	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	CD93 FBN2 VWCE SVEP1	4.51e-04	106	63	4	IPR000152
Domain	EGF_CA	CD93 FBN2 VWCE SVEP1	7.67e-04	122	63	4	SM00179
Domain	EGF-like_Ca-bd_dom	CD93 FBN2 VWCE SVEP1	8.15e-04	124	63	4	IPR001881
Domain	Kringle	LPA PLG	1.47e-03	17	63	2	IPR000001
Domain	Kringle_CS	LPA PLG	1.47e-03	17	63	2	IPR018056
Domain	KRINGLE_2	LPA PLG	1.47e-03	17	63	2	PS50070
Domain	Kringle	LPA PLG	1.47e-03	17	63	2	PF00051
Domain	KRINGLE_1	LPA PLG	1.47e-03	17	63	2	PS00021
Domain	KR	LPA PLG	1.47e-03	17	63	2	SM00130
Domain	Growth_fac_rcpt_	CD93 FBN2 VWCE SVEP1	1.90e-03	156	63	4	IPR009030
Domain	cEGF	CD93 FBN2	3.45e-03	26	63	2	IPR026823
Domain	cEGF	CD93 FBN2	3.45e-03	26	63	2	PF12662
Domain	hEGF	FBN2 SVEP1	4.00e-03	28	63	2	PF12661
Domain	Abhydrolase_1	SERHL2 SERHL	4.89e-03	31	63	2	PF00561
Domain	TRYPSIN_HIS	PRSS1 LPA PLG	5.09e-03	103	63	3	IPR018114
Domain	Kringle-like	LPA PLG	5.20e-03	32	63	2	IPR013806
Domain	TRYPSIN_SER	PRSS1 LPA PLG	5.51e-03	106	63	3	PS00135
Domain	AB_hydrolase_1	SERHL2 SERHL	5.53e-03	33	63	2	IPR000073
Domain	TRYPSIN_HIS	PRSS1 LPA PLG	5.66e-03	107	63	3	PS00134
Domain	Peptidase_S1A	PRSS1 LPA PLG	6.58e-03	113	63	3	IPR001314
Domain	TRYPSIN_DOM	PRSS1 LPA PLG	6.91e-03	115	63	3	PS50240
Domain	Tryp_SPc	PRSS1 LPA PLG	7.24e-03	117	63	3	SM00020
Domain	Trypsin	PRSS1 LPA PLG	7.94e-03	121	63	3	PF00089
Domain	Trypsin_dom	PRSS1 LPA PLG	7.94e-03	121	63	3	IPR001254
Domain	EGF_3	CD93 FBN2 VWCE SVEP1	8.15e-03	235	63	4	PS50026
Domain	EGF	CD93 FBN2 VWCE SVEP1	8.15e-03	235	63	4	SM00181
Domain	Peptidase_S1_PA	PRSS1 LPA PLG	8.30e-03	123	63	3	IPR009003
Domain	EGF-like_dom	CD93 FBN2 VWCE SVEP1	9.93e-03	249	63	4	IPR000742
Pubmed	Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.	LPA PLG	3.55e-06	2	66	2	31690812
Pubmed	Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.	LPA PLG	3.55e-06	2	66	2	30254165
Pubmed	Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice.	LPA PLG	3.55e-06	2	66	2	38328826
Pubmed	Reduced transplant arteriosclerosis in plasminogen-deficient mice.	LPA PLG	3.55e-06	2	66	2	9819364
Pubmed	Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.	LPA PLG	3.55e-06	2	66	2	10634603
Pubmed	Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.	LPA PLG	3.55e-06	2	66	2	23943648
Pubmed	In vivo plasminogen deficiency reduces fat accumulation.	LPA PLG	3.55e-06	2	66	2	12083480
Pubmed	Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.	LPA PLG	3.55e-06	2	66	2	18420257
Pubmed	Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.	LPA PLG	3.55e-06	2	66	2	7705657
Pubmed	Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin.	LPA PLG	3.55e-06	2	66	2	23041318
Pubmed	Plasminogen alleles influence susceptibility to invasive aspergillosis.	LPA PLG	3.55e-06	2	66	2	18566672
Pubmed	A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.	LPA PLG	3.55e-06	2	66	2	19752236
Pubmed	Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo.	SERHL2 SERHL	3.55e-06	2	66	2	11352564
Pubmed	Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.	LPA PLG	3.55e-06	2	66	2	6216475
Pubmed	The generation and characterization of mice expressing a plasmin-inactivating active site mutation.	LPA PLG	3.55e-06	2	66	2	20653841
Pubmed	Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.	LPA PLG	3.55e-06	2	66	2	12428098
Pubmed	Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.	LPA PLG	3.55e-06	2	66	2	20440070
Pubmed	Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.	LPA PLG	3.55e-06	2	66	2	24732409
Pubmed	A central role for plasminogen in the inflammatory response to biomaterials.	LPA PLG	3.55e-06	2	66	2	15456492
Pubmed	Plasminogen promotes macrophage phagocytosis in mice.	LPA PLG	3.55e-06	2	66	2	24876560
Pubmed	Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.	LPA PLG	3.55e-06	2	66	2	24574269
Pubmed	Spontaneous development of otitis media in plasminogen-deficient mice.	LPA PLG	3.55e-06	2	66	2	16956791
Pubmed	Staphylococcus aureus manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein.	LPA PLG	3.55e-06	2	66	2	25409527
Pubmed	The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.	LPA PLG	3.55e-06	2	66	2	1543918
Pubmed	Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.	LPA PLG	3.55e-06	2	66	2	8704243
Pubmed	Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.	LPA PLG	3.55e-06	2	66	2	17267741
Pubmed	Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.	LPA PLG	3.55e-06	2	66	2	23702659
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells.	LPA PLG	3.55e-06	2	66	2	29990619
Pubmed	Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector.	LPA PLG	3.55e-06	2	66	2	17293777
Pubmed	Plasminogen plays a crucial role in bone repair.	LPA PLG	3.55e-06	2	66	2	23456978
Pubmed	Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.	LPA PLG	3.55e-06	2	66	2	10854210
Pubmed	Gender affects skin wound healing in plasminogen deficient mice.	LPA PLG	3.55e-06	2	66	2	23527289
Pubmed	Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.	LPA PLG	3.55e-06	2	66	2	22079981
Pubmed	Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.	LPA PLG	3.55e-06	2	66	2	9490683
Pubmed	Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.	LPA PLG	3.55e-06	2	66	2	16481742
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation.	LPA PLG	3.55e-06	2	66	2	18983515
Pubmed	Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors.	LPA PLG	3.55e-06	2	66	2	34378815
Pubmed	Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.	LPA PLG	3.55e-06	2	66	2	11848464
Pubmed	Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.	LPA PLG	3.55e-06	2	66	2	7586361
Pubmed	Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.	LPA PLG	3.55e-06	2	66	2	21239499
Pubmed	Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.	LPA PLG	3.55e-06	2	66	2	10642175
Pubmed	Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA.	LPA PLG	3.55e-06	2	66	2	12225871
Pubmed	Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice.	LPA PLG	3.55e-06	2	66	2	9770530
Pubmed	Plasminogen activation is required for the development of radiation-induced dermatitis.	LPA PLG	3.55e-06	2	66	2	30323258
Pubmed	Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.	LPA PLG	3.55e-06	2	66	2	37971174
Pubmed	The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.	LPA PLG	3.55e-06	2	66	2	9884337
Pubmed	Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.	LPA PLG	3.55e-06	2	66	2	26473342
Pubmed	Nonfibrinolytic functions of plasminogen.	LPA PLG	3.55e-06	2	66	2	10816371
Pubmed	Plasminogen is a critical regulator of cutaneous wound healing.	LPA PLG	3.55e-06	2	66	2	26791370
Pubmed	Selection of mutant µplasmin for amyloid-β cleavage in vivo.	LPA PLG	3.55e-06	2	66	2	32694536
Pubmed	Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.	LPA PLG	3.55e-06	2	66	2	7525077
Pubmed	Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.	LPA PLG	3.55e-06	2	66	2	16052596
Pubmed	Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.	LPA PLG	3.55e-06	2	66	2	17122079
Pubmed	Role of plasminogen in propagation of scrapie.	LPA PLG	3.55e-06	2	66	2	16103174
Pubmed	Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.	LPA PLG	3.55e-06	2	66	2	21300353
Pubmed	Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation.	LPA PLG	3.55e-06	2	66	2	15737740
Pubmed	Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.	LPA PLG	3.55e-06	2	66	2	11306011
Pubmed	Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression.	LPA PLG	3.55e-06	2	66	2	12149246
Pubmed	Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.	LPA PLG	3.55e-06	2	66	2	22056679
Pubmed	Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis.	LPA PLG	3.55e-06	2	66	2	18311818
Pubmed	Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.	LPA PLG	3.55e-06	2	66	2	21190118
Pubmed	The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.	LPA PLG	3.55e-06	2	66	2	18039665
Pubmed	Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice.	LPA PLG	3.55e-06	2	66	2	9671388
Pubmed	A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response.	LPA PLG	3.55e-06	2	66	2	18997104
Pubmed	Growth and behavioral development in plasminogen gene-targeted mice.	LPA PLG	3.55e-06	2	66	2	10885855
Pubmed	Cellular density regulation of plasminogen gene expression in mouse hepatocytes.	LPA PLG	3.55e-06	2	66	2	12559391
Pubmed	Physiologic variations in blood plasminogen levels affect outcomes after acute cerebral thromboembolism in mice: a pathophysiologic role for microvascular thrombosis.	LPA PLG	3.55e-06	2	66	2	27319402
Pubmed	Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.	LPA PLG	3.55e-06	2	66	2	15333838
Pubmed	Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen.	LPA PLG	3.55e-06	2	66	2	16150044
Pubmed	Plasminogen has a broad extrahepatic distribution.	LPA PLG	3.55e-06	2	66	2	11916082
Pubmed	Unaltered prion protein cleavage in plasminogen-deficient mice.	LPA PLG	3.55e-06	2	66	2	16543819
Pubmed	Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice.	LPA PLG	3.55e-06	2	66	2	34423816
Pubmed	Delayed invasion of the kidney and brain by Borrelia crocidurae in plasminogen-deficient mice.	LPA PLG	3.55e-06	2	66	2	11500461
Pubmed	Growth of human squamous cell carcinoma xenografts in mice is inhibited by local angiostatin gene therapy.	LPA PLG	3.55e-06	2	66	2	12167431
Pubmed	Impaired wound healing in mice with a disrupted plasminogen gene.	LPA PLG	3.55e-06	2	66	2	8612226
Pubmed	Role of plasminogen activation in neuronal organization and survival.	LPA PLG	3.55e-06	2	66	2	19683575
Pubmed	Ovulation in plasminogen-deficient mice.	LPA PLG	3.55e-06	2	66	2	10537128
Pubmed	Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.	LPA PLG	3.55e-06	2	66	2	23555246
Pubmed	Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes.	LPA PLG	3.55e-06	2	66	2	18685433
Pubmed	Plasminogen mediates communication between the peripheral and central immune systems during systemic immune challenge with lipopolysaccharide.	LPA PLG	3.55e-06	2	66	2	31462325
Pubmed	Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.	LPA PLG	3.55e-06	2	66	2	9242524
Pubmed	Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.	LPA PLG	1.06e-05	3	66	2	16818777
Pubmed	Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.	LPA PLG	1.06e-05	3	66	2	19273908
Pubmed	Leveraging electronic health records to study pleiotropic effects on bipolar disorder and medical comorbidities.	CACNA1C SVEP1	1.06e-05	3	66	2	27529678
Pubmed	Lactational competence and involution of the mouse mammary gland require plasminogen.	LPA PLG	1.06e-05	3	66	2	11003846
Pubmed	Plasmin and plasminogen induce macrophage reprogramming and regulate key steps of inflammation resolution via annexin A1.	LPA PLG	1.06e-05	3	66	2	28320709
Pubmed	Plasminogen directs the pleiotropic effects of uPA in liver injury and repair.	LPA PLG	1.06e-05	3	66	2	12431907
Pubmed	Potentiation of TLR4 signalling by plasmin activity.	LPA PLG	1.06e-05	3	66	2	16413499
Pubmed	Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure.	LPA PLG	1.06e-05	3	66	2	33827130
Pubmed	Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system.	PRSS1 PLG	1.06e-05	3	66	2	12189145
Pubmed	Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain.	LPA PLG	1.06e-05	3	66	2	24612416
Pubmed	In vivo regulation of plasminogen function by plasma carboxypeptidase B.	LPA PLG	1.06e-05	3	66	2	12417566
Pubmed	Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins.	LPA PLG	1.06e-05	3	66	2	19465692
Pubmed	Alpha2-antiplasmin plays a significant role in acute pulmonary embolism.	LPA PLG	1.06e-05	3	66	2	12911586
Pubmed	Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes.	LPA PLG	1.06e-05	3	66	2	31316511
Pubmed	Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation.	LPA PLG	1.06e-05	3	66	2	16949567
Pubmed	Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury.	LPA PLG	1.06e-05	3	66	2	11733368
Pubmed	Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.	LPA PLG	1.06e-05	3	66	2	9294211
Pubmed	Plasmin-dependent proteolysis of tissue factor pathway inhibitor in a mouse model of endotoxemia.	LPA PLG	1.06e-05	3	66	2	23106863
Pubmed	Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.	LPA PLG	1.06e-05	3	66	2	15630096
Cytoband	Ensembl 112 genes in cytogenetic band chr6q26	LPA PLG	2.41e-04	16	66	2	chr6q26
Cytoband	6q26	LPA PLG	3.07e-04	18	66	2	6q26
Disease	chronic kidney disease, APOL1 risk genotype carrier status	LPA PLG	3.92e-05	5	59	2	EFO_0003884, EFO_0009324
Disease	plasma plasminogen measurement	LPA PLG	3.92e-05	5	59	2	EFO_0006309
Disease	angiostatin measurement	LPA PLG	5.87e-05	6	59	2	EFO_0008024
Disease	lipoprotein A measurement, apolipoprotein A 1 measurement	LPA PLG	8.20e-05	7	59	2	EFO_0004614, EFO_0006925
Disease	monokine induced by gamma interferon measurement	FNDC3B LPA PLG	1.57e-04	52	59	3	EFO_0008236
Disease	corneal resistance factor	TRAPPC13 FNDC3B FBN2 ZNF516 ADAMTS8 NPLOC4	2.80e-04	451	59	6	EFO_0010067
Disease	dystonia (is_implicated_in)	KMT2B MECR	3.52e-04	14	59	2	DOID:543 (is_implicated_in)
Disease	Manic Disorder	CACNA1C HDAC5 STARD9	3.94e-04	71	59	3	C0024713
Disease	Manic	CACNA1C HDAC5 STARD9	5.19e-04	78	59	3	C0338831
Disease	Depression, Bipolar	CACNA1C HDAC5 STARD9	5.39e-04	79	59	3	C0005587
Disease	corneal hysteresis	FNDC3B ADAMTS8	7.30e-04	20	59	2	EFO_0010066
Disease	Deep Vein Thrombosis	LPA PLG	8.05e-04	21	59	2	C0149871
Disease	Venous Thrombosis	LPA PLG	8.05e-04	21	59	2	C0042487
Disease	sleep duration, low density lipoprotein cholesterol measurement	LPA GPRC5C PLG	8.14e-04	91	59	3	EFO_0004611, EFO_0005271
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	LPA PLG L3MBTL3	9.22e-04	95	59	3	EFO_0004529, EFO_0008317, EFO_0008596
Disease	chylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement	LPA PLG L3MBTL3	9.51e-04	96	59	3	EFO_0004530, EFO_0008317, EFO_0008596
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement	LPA PLG L3MBTL3	1.27e-03	106	59	3	EFO_0008317, EFO_0008596
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipid measurement	LPA PLG L3MBTL3	1.37e-03	109	59	3	EFO_0004639, EFO_0008317, EFO_0008596
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	LPA PLG L3MBTL3	1.41e-03	110	59	3	EFO_0008317, EFO_0008596, EFO_0010351
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	LPA PLG L3MBTL3	1.41e-03	110	59	3	EFO_0008317, EFO_0008591, EFO_0008596
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	LPA PLG L3MBTL3	1.41e-03	110	59	3	EFO_0004574, EFO_0008317, EFO_0008596

Protein segments in the cluster

Peptide	Gene	Start	Entry
VGLGPGSTCLVKHLW	ERC2-IT1	76	O76042
GAEPLCHTKNGSLPW	ADAMTS8	481	Q9UP79
CHTKNGSLPWADGTP	ADAMTS8	486	Q9UP79
HCGCLPGWVLAPNGV	CD93	451	Q9NPY3
LGPAGSGKTTCWHSL	DNHD1	1991	Q96M86
GVSPHNWGDSGPPCK	DAXX	616	Q9UER7
GWCSKTGHPLQPPLS	L3MBTL3	531	Q96JM7
CWGPGPGGCLQTLLH	ANKFY1	716	Q9P2R3
GGPLKFSNPCILWLH	TRIT1	216	Q9H3H1
PGKGSFWALHPDCGD	FOXB2	81	Q5VYV0
QCGAGLTLLWSPPDH	KIAA0100	661	Q14667
KPLAFSGWASGCPSG	LZTS2	201	Q9BRK4
LLGAGPGLGTWPIHC	NUDT17	26	P0C025
PGLGTWPIHCSLKRG	NUDT17	31	P0C025
WGGQHCGCPAKSLPG	FAM182A	81	Q5T1J6
SPLPQPHGWGGLSKQ	KIAA1614	1161	Q5VZ46
CGPSPHWLLVTGRGA	CPSF1	946	Q10570
KSGCEGHLPWPNGIC	NPLOC4	191	Q8TAT6
PGLQHPVKASGCSWA	KDM4D	506	Q6B0I6
HQTGSWKCKEGPGPG	KMT2B	261	Q9UMN6
HLGWVKSGLGSGPKC	MGST3	136	O14880
QLGSGFQHWAGLPCP	OLIG3	226	Q7RTU3
PGKGSFWALHPSCGD	FOXB1	81	Q99853
AWAQGHVPPGCSQGL	GPRC5C	21	Q9NQ84
NGLSQGPPCWDLHPG	PARD6A	296	Q9NPB6
HSPGLPWLDGGKAAL	GATA2	91	P23769
LPWATNHPGPGCLSD	GIG44	96	P09565
VCKPGWDGPKHGITN	CACNA1C	331	Q13936
SKGHGSWSGPSPQCL	CR2	766	P20023
HCGGGLANWKPKEDP	BIRC8	41	Q96P09
KLPSPDSGHSLLCGW	C21orf58	21	P58505
WAPPVGLSCGPHSGL	FNDC3B	296	Q53EP0
GFVGWPCLGPISSAH	CCDC188	36	H7C350
LSPLPGLGGHWACSE	FAM25E	46	A8MYX2
GVTSWGLGCARPNKP	LPA	2006	P08519
LRTHAPCWGTGGAPA	GPR173	351	Q9NS66
CAGPGAHAGLPLWAL	GP5	451	P40197
QWRGLLPASGCHGPA	MECR	16	Q9BV79
GGLNHSLPQHPKCWG	HDAC5	201	Q9UQL6
RGWGHQCELCPLPGT	FBN2	2416	P35556
AWGSLQGPPVLCLHG	SERHL2	26	Q9H4I8
LLSLPGGWLHCPKDF	SLC15A3	516	Q8IY34
AWGSLQGPPVLCLHG	SERHL	26	Q9NQF3
PPGWSQLFLGTVCKG	TRMT2B	36	Q96GJ1
AVMSPCPLLQGHWGG	SLC52A3	381	Q9NQ40
VGWLCSSPGAPIGVH	TCAF1	81	Q9Y4C2
PTSLGGGLPYCHQAW	PLEKHG4	316	Q58EX7
LKKPSLLGGACHPWL	SGSM3	576	Q96HU1
AGKSAQLGLHPWLPS	MT-ND5	221	P03915
CWLQPDAPGPGEHGL	SWSAP1	166	Q6NVH7
PSSWGGLQHLSPCPV	STARD9	4076	Q9P2P6
RAPSCHLGGPNTLKW	TEX45	186	Q8NA69
SHILKGNWCPGPGSL	TEX45	311	Q8NA69
GVTSWGLGCARPNKP	PLG	776	P00747
GENGHWLGGKPTCKA	SVEP1	2481	Q4LDE5
TLHQPGGWICGKDPC	C11orf96	26	Q7Z7L8
NKESHSGGPCALWAP	ZNF516	866	Q92618
SGWPGLLMSCLKGPH	RNF208	11	Q9H0X6
KLGCPTAWINPHGRG	SLC27A5	196	Q9Y2P5
GAREPGWCKTPSGHI	SOX12	26	O15370
SGQKLASWPSCTPGH	RHBDD2	276	Q6NTF9
LTLPFGAWRGHPGCT	STPG3	286	Q8N7X2
PGKCWAFPGSQGHTL	SUN3	236	Q8TAQ9
FHAGGSKCSTWPLPQ	PRLR	406	P16471
GWAPSMGGGHCTLPL	VWCE	56	Q96DN2
HKPLLGTEKCIWGPS	PSAP	486	P07602
SSGAPFWSGPKRCPH	UBA1	736	P22314
LWGPPGCGKTTLAHI	WRNIP1	266	Q96S55
GALGCAGPKPALISW	ZNF689	66	Q96CS4
RWNCPTAPGPHLFGK	WNT1	101	P04628
APPATGTKCLISGWG	PRSS1	131	P07477
WCGISGRQLGKLHPS	TRAPPC13	351	A5PLN9
PHTDNIGRGPCSWGL	TRIM65	411	Q6PJ69
LGCAAPHSGWAGLTP	MYO7A	1536	Q13402
PHSGWAGLTPAGPCS	MYO7A	1541	Q13402