Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11

1.08e-0482604GO:1990756
GeneOntologyMolecularFunctionubiquitin conjugating enzyme binding

ANKIB1 SIAH1 SIAH2

1.72e-0436603GO:0031624
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11

1.91e-0495604GO:0140767
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme binding

ANKIB1 SIAH1 SIAH2

2.72e-0442603GO:0044390
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF15 PRAMEF4 PRAMEF11

6.05e-0455603GO:0042974
GeneOntologyMolecularFunctionfatty-acyl-CoA binding

HNF4A SOAT2

1.97e-0322602GO:0000062
GeneOntologyMolecularFunctionfatty acid derivative binding

HNF4A SOAT2

2.35e-0324602GO:1901567
GeneOntologyMolecularFunctionacyl-CoA binding

HNF4A SOAT2

2.75e-0326602GO:0120227
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

FBXL13 PRAMEF9 PRAMEF15 KBTBD8 SIAH1 PRAMEF4 PRAMEF11

2.45e-06212607GO:0031461
GeneOntologyCellularComponentubiquitin ligase complex

FBXL13 PRAMEF9 PRAMEF15 KBTBD8 ANKIB1 SIAH1 PRAMEF4 PRAMEF11

7.12e-06352608GO:0000151
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11

9.97e-0647604GO:0031462
GeneOntologyCellularComponentclathrin-sculpted gamma-aminobutyric acid transport vesicle

SLC32A1 GAD1

2.24e-048602GO:0061200
GeneOntologyCellularComponentclathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

SLC32A1 GAD1

2.24e-048602GO:0061202
GeneOntologyCellularComponenttransferase complex

FBXL13 PRAMEF9 UBE2I TUSC3 PRAMEF15 KBTBD8 ANKIB1 SIAH1 PRAMEF4 PRAMEF11

3.81e-049636010GO:1990234
GeneOntologyCellularComponentclathrin-sculpted vesicle

SLC32A1 GAD1

9.47e-0416602GO:0060198
Domain7-in-absentia-prot_TRAF-dom

SIAH1 SIAH2

2.74e-053572IPR018121
DomainSina

SIAH1 SIAH2

2.74e-053572PF03145
DomainSINA-like

SIAH1 SIAH2

5.47e-054572IPR004162
DomainZnf_SIAH

SIAH1 SIAH2

5.47e-054572IPR013010
DomainZF_SIAH

SIAH1 SIAH2

9.10e-055572PS51081
Domain-

SIAH1 SIAH2

8.13e-04145723.90.890.10
Domain-

SIAH1 SIAH2

8.13e-04145722.60.210.10
DomainSIAH-type

SIAH1 SIAH2

1.07e-0316572IPR013323
DomainPRAME_family

PRAMEF15 PRAMEF4

1.51e-0319572IPR026271
Domain-

HERC5 TECPR1

2.03e-03225722.130.10.30
DomainRCC1/BLIP-II

HERC5 TECPR1

2.22e-0323572IPR009091
DomainTRAF-like

SIAH1 SIAH2

2.42e-0324572IPR008974
Pubmed

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.

UBE2I SIAH1 SIAH2

2.05e-0846139334332
Pubmed

A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation.

UBE2I SIAH1 SIAH2

4.28e-07961317533377
Pubmed

An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.

SIAH1 SIAH2 SNRNP200

6.11e-071061323500468
Pubmed

Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes.

UBE2I SIAH1 SIAH2

8.39e-071161327485016
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

THSD7A PRAMEF15 KBTBD8 SIAH1 PRAMEF4 RNASEH1 PRAMEF11

1.69e-0632661717015433
Pubmed

Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

SIAH1 SIAH2

3.03e-06261224809345
Pubmed

Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).

SIAH1 SIAH2

3.03e-0626128404535
Pubmed

Characterization of human homologs of the Drosophila seven in absentia (sina) gene.

SIAH1 SIAH2

3.03e-0626129403064
Pubmed

Dimerization of hSiah proteins regulates their stability.

SIAH1 SIAH2

3.03e-06261216899216
Pubmed

Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons.

SLC32A1 GAD1

3.03e-06261229915137
Pubmed

Inhibition of Siah ubiquitin ligase function.

SIAH1 SIAH2

3.03e-06261218850011
Pubmed

Generation and analysis of Siah2 mutant mice.

SIAH1 SIAH2

3.03e-06261214645526
Pubmed

SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.

SIAH1 SIAH2

3.03e-06261226654769
Pubmed

Alterations in hypoglossal motor neurons due to GAD67 and VGAT deficiency in mice.

SLC32A1 GAD1

3.03e-06261227956032
Pubmed

Heteromerization of ciliary G protein-coupled receptors in the mouse brain.

MCHR1 SSTR3

3.03e-06261223029470
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF15 PRAMEF4 PRAMEF11

3.43e-061761323565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF15 PRAMEF4 PRAMEF11

3.43e-061761337781892
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF15 PRAMEF4 PRAMEF11

4.11e-061861323894331
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF15 PRAMEF4 PRAMEF11

4.11e-061861312890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF15 PRAMEF4 PRAMEF11

4.11e-061861329731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF15 PRAMEF4 PRAMEF11

4.11e-061861314675769
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF15 PRAMEF4 PRAMEF11

4.11e-061861339181896
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF15 PRAMEF4 PRAMEF11

4.88e-061961328604677
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF15 PRAMEF4 PRAMEF11

5.73e-062061326694250
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF15 PRAMEF4 PRAMEF11

5.73e-062061316580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF15 PRAMEF4 PRAMEF11

5.73e-062061321425410
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF15 PRAMEF4 PRAMEF11

7.72e-062261331729367
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF15 PRAMEF4 PRAMEF11

8.87e-062361319480014
Pubmed

Two novel cis-elements involved in hepatocyte nuclear factor 4α regulation of acyl-coenzyme A:cholesterol acyltransferase 2 expression.

HNF4A SOAT2

9.07e-06361222155889
Pubmed

Normal p53 function in primary cells deficient for Siah genes.

SIAH1 SIAH2

9.07e-06361212417719
Pubmed

Recurrent network activity drives striatal synaptogenesis.

SLC32A1 GAD1

9.07e-06361222660328
Pubmed

The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear.

SIAH1 SIAH2

9.07e-06361227776223
Pubmed

Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia.

SLC32A1 GAD1

9.07e-06361217471287
Pubmed

Raphe serotonin projections dynamically regulate feeding behavior through targeting inhibitory circuits from rostral zona incerta to paraventricular thalamus.

SLC32A1 GAD1

9.07e-06361236351530
Pubmed

Distinct CCK-positive SFO neurons are involved in persistent or transient suppression of water intake.

SLC32A1 GAD1

9.07e-06361233173030
Pubmed

Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.

SIAH1 SIAH2

9.07e-06361212810624
Pubmed

Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.

SIAH1 SIAH2

9.07e-06361210681424
Pubmed

Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO.

SIAH1 SIAH2

9.07e-06361225561546
Pubmed

Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control.

SLC32A1 GAD1

9.07e-06361231548232
Pubmed

Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.

SIAH1 SIAH2

9.07e-06361221109632
Pubmed

The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.

SIAH1 SIAH2

9.07e-06361214645235
Pubmed

The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice.

SIAH1 SIAH2

9.07e-06361211884614
Pubmed

Respiratory activity in brainstem of fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter.

SLC32A1 GAD1

9.07e-06361217418495
Pubmed

GAD65/GAD67 double knockout mice exhibit intermediate severity in both cleft palate and omphalocele compared with GAD67 knockout and VGAT knockout mice.

SLC32A1 GAD1

9.07e-06361225545713
Pubmed

Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma.

SIAH1 SIAH2

9.07e-06361237078793
Pubmed

SUMOylation of HNF4α regulates protein stability and hepatocyte function.

UBE2I HNF4A

9.07e-06361222505616
Pubmed

Investigating the molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity.

SIAH1 SIAH2

9.07e-06361225202994
Pubmed

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.

SIAH1 SIAH2

9.07e-06361219043406
Pubmed

Siah proteins induce the epidermal growth factor-dependent degradation of phospholipase Cepsilon.

SIAH1 SIAH2

9.07e-06361217998205
Pubmed

The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer.

SIAH1 SIAH2

9.07e-06361225528765
Pubmed

Diverse inhibitory projections from the cerebellar interposed nucleus.

SLC32A1 GAD1

9.07e-06361234542410
Pubmed

Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior.

SLC32A1 GAD1

9.07e-06361229174921
Pubmed

Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior.

SLC32A1 GAD1 CLDN5

1.01e-052461329086765
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF15 PRAMEF4 PRAMEF11

1.15e-052561337451217
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF15 PRAMEF4 PRAMEF11

1.15e-052561312620990
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF15 PRAMEF4 PRAMEF11

1.30e-052661318500982
Pubmed

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.

FBXL13 SIAH1 SIAH2 HERC5

1.56e-058561419028597
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF15 PRAMEF4 PRAMEF11

1.63e-052861325089626
Pubmed

Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?

SIAH1 SIAH2

1.81e-05461215221006
Pubmed

The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice.

SLC32A1 GAD1

1.81e-05461221190592
Pubmed

Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia.

SIAH1 SIAH2

1.81e-05461222099302
Pubmed

Corelease of acetylcholine and GABA from cholinergic forebrain neurons.

SLC32A1 GAD1

1.81e-05461225723967
Pubmed

Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.

SIAH1 SIAH2

1.81e-05461218070888
Pubmed

SIAH proteins regulate the degradation and intra-mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease.

SIAH1 SIAH2

1.81e-05461236307912
Pubmed

Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite.

SLC32A1 GAD1

1.81e-05461238157299
Pubmed

Cleft palate is caused by CNS dysfunction in Gad1 and Viaat knockout mice.

SLC32A1 GAD1

1.81e-05461220333300
Pubmed

Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia.

SIAH1 SIAH2

1.81e-05461222128162
Pubmed

GABA in the suprachiasmatic nucleus refines circadian output rhythms in mice.

SLC32A1 GAD1

1.81e-05461231263776
Pubmed

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.

SIAH1 SIAH2

1.81e-05461215064394
Pubmed

Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum.

SLC32A1 GAD1

1.81e-05461229487284
Pubmed

Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord.

SLC32A1 GAD1

1.81e-05461223044470
Pubmed

Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.

SIAH1 SIAH2

1.81e-0546129858595
Pubmed

Distinct development of the glycinergic terminals in the ventral and dorsal horns of the mouse cervical spinal cord.

SLC32A1 GAD1

1.81e-05461228039040
Pubmed

Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.

MCHR1 SSTR3

1.81e-05461218334641
Pubmed

Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model.

SLC32A1 GAD1

1.81e-05461236835612
Pubmed

Siah-1 is associated with expression of hypoxia-inducible factor-1α in oral squamous cell carcinoma.

SIAH1 SIAH2

1.81e-05461227616748
Pubmed

A proteomic study of SUMO-2 target proteins.

UBE2I SNRNP200

1.81e-05461215175327
Pubmed

P-TEFb is degraded by Siah1/2 in quiescent cells.

SIAH1 SIAH2

1.81e-05461235524561
Pubmed

Limbic Neurons Shape Sex Recognition and Social Behavior in Sexually Naive Males.

SLC32A1 GAD1

1.81e-05461230712868
Pubmed

Regulation of BOB.1/OBF.1 stability by SIAH.

SIAH1 SIAH2

1.81e-05461211483518
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF15 PRAMEF4 PRAMEF11

2.02e-053061338786026
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF15 PRAMEF4 PRAMEF11

2.46e-053261337889087
Pubmed

Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.

SIAH1 SIAH2

3.02e-05561219224863
Pubmed

SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway.

SIAH1 SIAH2

3.02e-05561214654780
Pubmed

Tfap2b acts in GABAergic neurons to control sleep in mice.

SLC32A1 GAD1

3.02e-05561237198238
Pubmed

hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways.

SIAH1 SIAH2

3.02e-05561210207103
Pubmed

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.

SIAH1 SIAH2

3.02e-05561228546513
Pubmed

Lack of molecular-anatomical evidence for GABAergic influence on axon initial segment of cerebellar Purkinje cells by the pinceau formation.

SLC32A1 GAD1

3.02e-05561222764252
Pubmed

Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ.

SLC32A1 GAD1

3.02e-05561227991901
Pubmed

Regulation of synaptophysin degradation by mammalian homologues of seven in absentia.

SIAH1 SIAH2

3.02e-05561211786535
Pubmed

Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons.

SLC32A1 GAD1

3.02e-05561223258346
Pubmed

Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin and Melanin-Concentrating Hormone Neurons Identified Through Single-Cell Gene Expression Analysis.

SLC32A1 MCHR1

3.02e-05561228966976
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF15 PRAMEF4 PRAMEF11

3.23e-053561319389355
Pubmed

SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation.

SIAH1 SIAH2

4.52e-05661223208506
Pubmed

Dopaminergic neurons inhibit striatal output through non-canonical release of GABA.

SLC32A1 GAD1

4.52e-05661223034651
Pubmed

Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.

SIAH1 SIAH2

4.52e-05661216174773
Pubmed

Central Control Circuit for Context-Dependent Micturition.

SLC32A1 GAD1

4.52e-05661227662084
Pubmed

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.

SIAH1 SIAH2

4.52e-05661215210114
Pubmed

Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features.

SLC32A1 GAD1

4.52e-05661238917805
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

IARS2 PLEKHM2 WDR7 PI4KA TNRC6A ANKRD50 SNRNP200 PPM1G

6.20e-0577761835844135
InteractionSV2C interactions

MCHR1 SSTR3 NPLOC4

1.37e-0516603int:SV2C
InteractionPRAMEF4 interactions

PRAMEF9 PRAMEF4

2.61e-053602int:PRAMEF4
Cytoband1p36.21

PRAMEF9 PLEKHM2 PRAMEF15 PRAMEF4 PRAMEF11

2.32e-08636151p36.21
CytobandEnsembl 112 genes in cytogenetic band chr1p36

PRAMEF9 PLEKHM2 PRAMEF15 TAS1R2 PRAMEF4 PRAMEF11

2.90e-04681616chr1p36
Cytoband11q25

PRDM10 ACAD8

5.53e-042661211q25
GeneFamilyPRAME family

PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11

2.85e-0724434686
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED

NRK PRAMEF15 PRAMEF4 PRAMEF11

8.95e-0657604MM1262
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALNT14 GAD1 WDR7 FAM151A SIAH2 SSTR3

2.79e-07195616bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAD1 SLC14A1 CP ZC3H12B TECPR1

2.71e-0616061555f599df6e3b7a5a505df4b094c834281311d94a
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAD1 SLC14A1 CP ZC3H12B TECPR1

2.71e-06160615296e53e1e0786346d38db2d4188b9a1c0430627b
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC32A1 GALNT14 GAD1 THSD7A CP

3.44e-06168615f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALNT14 GAD1 FAM151A SIAH2 SSTR3

6.75e-06193615471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma-5|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11

8.16e-06936143e05ea0f8f4a7cdb78a596f47d563dc3c94d4d8e
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPRQ TAS1R2 RHBDL1 SOAT2

1.59e-05110614c80d1c3df75648e2c8f6832279c2acca63d76681
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Car10|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC32A1 GALNT14 GAD1 THSD7A

2.79e-05127614f808c727c0817ed10e76eaffa9493a516e9a6b50
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Thalamus / BrainAtlas - Mouse McCarroll V32

SLC32A1 GAD1 MCHR1 DGKK

5.07e-05148614afebb64365c94b9476494bffe7c364677f19c8cf
ToppCellThalamus-Neuronal-Inhibitory|Thalamus / BrainAtlas - Mouse McCarroll V32

SLC32A1 GAD1 MCHR1 DGKK

5.07e-051486145f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC32A1 GAD1 THSD7A CP

5.21e-0514961410ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC32A1 GAD1 THSD7A CP

6.07e-05155614cba6f3f7742b4d5d54ad0a0ac0dd4016e73fe658
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC32A1 GAD1 THSD7A CP

6.07e-0515561499e749f7075e2c64e9a0bf91009f95b6969197c8
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Cabp7_(Retrosplenial_areas,_subiculum,_presubiculum,_Cabp7+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CD163L1 DGKK TAS1R2

6.59e-055761369d867b775be8e68d274c149e406cc306cee7f63
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Cabp7_(Retrosplenial_areas,_subiculum,_presubiculum,_Cabp7+)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CD163L1 DGKK TAS1R2

6.59e-05576136bf3886d5ebe6bf65a503648ac455415cbb4fc6c
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC32A1 GALNT14 GAD1 THSD7A

7.03e-051616143b5d7a3dab479c6959a428f3954dedd989900276
ToppCellEndothelial-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

GALNT14 THSD7A CLEC4G CLDN5

8.10e-051676146a03d16165e0b003092c39972928981abd4a75aa
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MCHR1 FAR2 RHBDL1 HERC5

8.10e-05167614b742558ca92985db0a67c88f530bc375f3d3bb98
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC32A1 GALNT14 GAD1 CP

8.88e-051716145efd15300f865ebf651e0888265cbd717bc3b9d3
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_THEMIS_PLA2G7|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CD163L1 DGKK CLEC4G B3GALT5

9.08e-051726141d086e00cd549459d70e1d3b468d5ab6379f3bee
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC32A1 GALNT14 GAD1 CP

9.08e-051726147e1a7700a4c2b1d100da1d6e475e73498ebb605a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC14A1 PLEKHM2 CP CLDN5

9.92e-051766141df7b6ce2519ad99bacbbaf1a8d5929e11513faa
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GAD1 THSD7A CD163L1

1.01e-0417761484116796ca4c7007508c0f1a68a1135c7b922278
ToppCellNS-critical-d_0-4-Myeloid-Mast_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

THSD7A WDR7 SIAH1 PARP15

1.06e-041796146153e7a0eeae83e7d88f1a20093bf2113e8d66b1
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GALNT14 GAD1 THSD7A

1.11e-0418161435bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A PTPRQ CLDN5 SSTR3

1.13e-04182614cde8fa4f42d25545abaa9ee885b4b1e24a5a8e08
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175|Adult / Lineage, Cell type, age group and donor

GALNT14 NRK TUSC3 CLDN5

1.13e-041826148b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRK DGKK PTPRQ ADAMTS20

1.18e-04184614ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRK DGKK PTPRQ ADAMTS20

1.18e-041846142cbed6462fea2622871bb7e49b0df3d984239281
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GAD1 THSD7A CD163L1

1.18e-0418461432473dbdb2de66391157c5814ef34e790806e4f2
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRK DGKK PTPRQ ADAMTS20

1.18e-041846142b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GALNT14 GAD1 ADAMTS20

1.18e-0418461423515c28e1f42aab29cef9e5b4a7f45bda7f5520
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GALNT14 GAD1 ADAMTS20

1.18e-041846147f6c8912677764d438ab0555faca344d74c2f483
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A PTPRQ CLDN5 SSTR3

1.23e-041866141094c7140131454b2583200e1c01e81ccab3db23
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GALNT14 GAD1 ADAMTS20

1.25e-0418761485f1678338a47d91e296f0620d4887f057eb7e70
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GAD1 THSD7A CD163L1

1.28e-041886146ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCellCOVID-19-kidney-DCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

GALNT14 GAD1 THSD7A NRK

1.28e-041886141d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCell15-Distal-RBC|Distal / Age, Tissue, Lineage and Cell class

SLC14A1 CP HNF4A SOAT2

1.28e-04188614c68ccb1c5c21d13ddac09b16e7d466f0530bbda5
ToppCell15-Distal-RBC-RBC|Distal / Age, Tissue, Lineage and Cell class

SLC14A1 CP HNF4A SOAT2

1.28e-041886142534684e4932c1255c24a26ca2277ac7af0a118b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GAD1 THSD7A CD163L1

1.39e-041926146a252e298f8a454623fa9c1c893a7a45a886d694
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

THSD7A MCHR1 CP ANKRD50

1.39e-04192614c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GAD1 THSD7A CD163L1

1.39e-04192614025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALNT14 FAM151A SIAH2 SSTR3

1.41e-04193614fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GALNT14 GAD1 ADAMTS20

1.41e-04193614010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 GALNT14 GAD1 ADAMTS20

1.44e-04194614e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCell(5)_Epithelial_cells-(5)_Epi_basal|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

THSD7A CP B3GALT5 CLDN5

1.44e-04194614b887b2ff19b76bd93c67f9a24762efae816efd45
ToppCellfacs-Pancreas-Endocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALNT14 FAM151A CLEC4G SSTR3

1.47e-04195614bc8a39fdf70faa187ba40c46fb9674a604795c9e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A SLC14A1 CP CLDN5

1.47e-04195614d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALNT14 GAD1 FAM151A SSTR3

1.47e-0419561458b769da05a8f6b05aeb08d4f8b112941087ad00
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A SLC14A1 CP CLDN5

1.50e-04196614a20a56d8997d6db2a10046c8801c619a379de83c
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

THSD7A TUSC3 CP CLDN5

1.53e-04197614ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THSD7A TUSC3 CLDN5 APOBEC3B

1.56e-04198614002424b24dacac553e02d0f764a6e8a1e567b9df
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Artery-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

THSD7A SLC14A1 TUSC3 CLDN5

1.62e-04200614622206c33640cb2694fe158e8dc55515bb7bd4f5
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Artery|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

THSD7A SLC14A1 TUSC3 CLDN5

1.62e-04200614590d1c0f86f136c7e76ea107fbb8ac5ff1164386
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Artery|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

THSD7A SLC14A1 TUSC3 CLDN5

1.62e-042006145b4a54cd81bc4d9f5e92798362239e1aa1b70bee
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Neuron|10w / Sample Type, Dataset, Time_group, and Cell type.

THSD7A MCHR1 CLEC4G SOAT2

1.62e-04200614332905a686356cd1e024d40679be98e9d8b1b5e8
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLC32A1 GAD1 THSD7A CD163L1

1.62e-042006147e51715525fdb001b7042b2bfcb9de81ecb5e4ee
DrugEdotreotide

MCHR1 LSS SSTR3

4.64e-0613593CID000158782
Diseasealcohol use disorder (implicated_via_orthology)

SLC32A1 GAD1 RHBDL1 HNF4A

5.56e-04195574DOID:1574 (implicated_via_orthology)
DiseaseRetinal Degeneration

CP RPE65

7.52e-0421572C0035304
DiseaseAbnormality of refraction

GALNT14 THSD7A FAR2 UBE2I ADAMTS20 NPLOC4

1.86e-03673576HP_0000539

Protein segments in the cluster

PeptideGeneStartEntry
MVWQHCDCMGVNSDV

ASH1L

2606

Q9NR48
WIKPGDHVMMEVSCQ

PRMT9

446

Q6P2P2
GTWVLMDQHMGFLCN

APOBEC3B

226

Q9UH17
HNMCAWMIDSFGNEE

ACAD8

126

Q9UKU7
MMGIEWVHRFCPQAA

B3GALT5

136

Q9Y2C3
GNIMAWFHDMNPQSI

ANKIB1

971

Q9P2G1
TALHVSCWQGHMEMV

ANKRD50

981

Q9ULJ7
SCWQGHMEMVQVLIA

ANKRD50

986

Q9ULJ7
MMLPQNSWHIDFGRC

CD163L1

1

Q9NR16
GSQMCPHINICMHLW

ADAMTS20

496

P59510
MVAQNPGEWMLSCQN

CP

326

P00450
TSGNMNPCNWHKMGV

FAR2

306

Q96K12
NMPHQWVEGNMPVSS

DGKK

396

Q5KSL6
SMTTCNLPEHWTDMN

PARP15

476

Q460N3
TCMETMWEIPAIGHF

KIAA2026

296

Q5HYC2
WNPHKMMGVLLQCSA

GAD1

401

Q99259
NTMPTHLSNGQMCEW

HNF4A

406

P41235
AAMWACQHCTFMNQP

NPLOC4

581

Q8TAT6
NTCWAMMGLMAVRHP

LSS

651

P48449
VCLQNCHLAVSWMPM

DNAH12

2551

Q6ZR08
MFNEHGMETALACWE

PI4KA

1221

P42356
MVWSEAMAHGCFLNA

PRAMEF15

116

P0DUQ1
CNWMMFVRPAQNHLE

PRDM10

281

Q9NQV6
NTAHGNMACVVWEPM

EIPR1

131

Q53HC9
WTTVCAMPVAMEFHN

KBTBD8

421

Q8NFY9
VPDVVQNMQCMATSW

PTPRQ

1381

Q9UMZ3
NPCESSLMSQHWDMV

GALNT14

536

Q96FL9
CPMMHISNNWESLVV

HERC5

496

Q9UII4
MNWDTLGHQCFISMS

WDPCP

511

O95876
GSNSFMHSMVPQLEW

DNM1P34

16

Q6PK57
CQGLWQPVSFQMQAM

FAM151A

501

Q8WW52
PWVQIFENKGAMMGC

GALT

166

P07902
IICGQVNHAWMLMTQ

FBXL13

176

Q8NEE6
QLMGNGVWHFGETMC

MCHR1

171

Q99705
MAEWMQHLCQAVSKG

PLEKHM2

861

Q8IWE5
QRHQLWMVMELCAAG

NRK

121

Q7Z2Y5
MDCFESNETMGVWLH

RPE65

276

Q16518
RGMSTCHMQWPEPAA

SSTR3

186

P32745
KNWQMNTSCMVECPV

THSD7A

1271

Q9UPZ6
AELWAPNMCHLQLME

TEDDM1

146

Q5T9Z0
AMQGWRVSMEDAHNC

PPM1G

31

O15355
NLPGAVDWVMMQSCF

SIAH1

171

Q8IUQ4
NLPGAVDWVMMQSCF

SIAH2

211

O43255
MMNGSKIHFVPGWDC

IARS2

141

Q9NSE4
AHLANVVMNWAGMRC

RHBDL1

321

O75783
NFMMHDQRTGPAWNV

SOAT2

461

O75908
WMSCVVQSTGHMQCK

CLDN5

51

O00501
NDAWGRENCVMMLHT

CLEC4G

256

Q6UXB4
TQGMDIQWMHVPGHS

RNASEH1

251

O60930
MVWSEAMAHGCFLNA

PRAMEF4

116

O60810
LCIVFAMTSGQMWNH

TUSC3

236

Q13454
NPDGTMNLMNWECAI

UBE2I

31

P63279
MVWSEAMAHGCFLNA

PRAMEF9

116

P0DUQ2
HNPCGTSWIEMVGEM

TECPR1

321

Q7Z6L1
MVWSEAMAHGCFLNA

PRAMEF11

116

O60813
LMHMPAEQAFWCLVQ

TBC1D10B

456

Q4KMP7
MANFMAEVGLPACTW

SLC14A1

326

Q13336
ISWHTINNTIPMSMC

TAS1R2

481

Q8TE23
WVGMCNDSREHMIPE

ZC3H12B

776

Q5HYM0
CWGMNVAAHLVIIMD

SNRNP200

1651

O75643
QQPSEFHCMMNWTHI

SLC32A1

331

Q9H598
NEGWSQLAAMHCVML

WDR7

981

Q9Y4E6
GAWRVSTMNHPQMQA

TNRC6A

481

Q8NDV7