Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	POTEE POTEF POTEI	6.11e-06	11	68	3	GO:0098973
GeneOntologyMolecularFunction	peroxidase activity	GSTK1 LPO GSTA1 GSTA2	7.12e-05	65	68	4	GO:0004601
GeneOntologyMolecularFunction	oxidoreductase activity, acting on peroxide as acceptor	GSTK1 LPO GSTA1 GSTA2	8.02e-05	67	68	4	GO:0016684
GeneOntologyMolecularFunction	dinitrosyl-iron complex binding	GSTA1 GSTA2	1.14e-04	5	68	2	GO:0035731
GeneOntologyMolecularFunction	glutathione peroxidase activity	GSTK1 GSTA1 GSTA2	1.16e-04	28	68	3	GO:0004602
GeneOntologyMolecularFunction	glutathione transferase activity	GSTK1 GSTA1 GSTA2	1.30e-04	29	68	3	GO:0004364
GeneOntologyMolecularFunction	structural constituent of postsynapse	POTEE POTEF POTEI	1.75e-04	32	68	3	GO:0099186
GeneOntologyMolecularFunction	helicase activity	DDX46 SETX CHD3 CHD4 DICER1	2.03e-04	158	68	5	GO:0004386
GeneOntologyMolecularFunction	steroid delta-isomerase activity	GSTA1 GSTA2	2.37e-04	7	68	2	GO:0004769
GeneOntologyMolecularFunction	antioxidant activity	GSTK1 LPO GSTA1 GSTA2	3.36e-04	97	68	4	GO:0016209
GeneOntologyMolecularFunction	structural constituent of synapse	POTEE POTEF POTEI	3.94e-04	42	68	3	GO:0098918
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2D SMYD2	5.05e-04	10	68	2	GO:0140999
GeneOntologyMolecularFunction	transferase activity, transferring alkyl or aryl (other than methyl) groups	GSTK1 GSTA1 GSTA2	1.36e-03	64	68	3	GO:0016765
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	DDX46 SETX RNASEL CHD3 CHD4 NIPBL DICER1 NARS2	1.52e-03	645	68	8	GO:0140640
GeneOntologyMolecularFunction	glutathione binding	GSTA1 GSTA2	1.69e-03	18	68	2	GO:0043295
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity, transposing C=C bonds	GSTA1 GSTA2	1.88e-03	19	68	2	GO:0016863
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	SETX CHD3 CHD4 NIPBL DICER1	1.99e-03	262	68	5	GO:0140097
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2D SMYD2	2.09e-03	20	68	2	GO:0042800
GeneOntologyMolecularFunction	oligopeptide binding	GSTA1 GSTA2	2.09e-03	20	68	2	GO:1900750
GeneOntologyCellularComponent	NuA4 histone acetyltransferase complex	POTEE POTEF POTEI	1.53e-04	32	68	3	GO:0035267
GeneOntologyCellularComponent	H4/H2A histone acetyltransferase complex	POTEE POTEF POTEI	1.53e-04	32	68	3	GO:0043189
GeneOntologyCellularComponent	H4 histone acetyltransferase complex	POTEE POTEF POTEI	4.24e-04	45	68	3	GO:1902562
GeneOntologyCellularComponent	SCAR complex	CYFIP2 NCKAP1L	6.74e-04	12	68	2	GO:0031209
Domain	Actin_CS	POTEE POTEF POTEI	2.39e-05	16	67	3	IPR004001
Domain	ACTINS_2	POTEE POTEF POTEI	2.89e-05	17	67	3	PS00432
Domain	Actin/actin-like_CS	POTEE POTEF POTEI	3.46e-05	18	67	3	IPR020902
Domain	Qua1	KHDRBS3 KHDRBS1	3.79e-05	3	67	2	PF16274
Domain	CHDCT2	CHD3 CHD4	3.79e-05	3	67	2	PF08074
Domain	CHDNT	CHD3 CHD4	3.79e-05	3	67	2	PF08073
Domain	DUF1086	CHD3 CHD4	3.79e-05	3	67	2	IPR009462
Domain	DUF1087	CHD3 CHD4	3.79e-05	3	67	2	IPR009463
Domain	Qua1_dom	KHDRBS3 KHDRBS1	3.79e-05	3	67	2	IPR032571
Domain	Sam68-YY	KHDRBS3 KHDRBS1	3.79e-05	3	67	2	IPR032335
Domain	CHD_N	CHD3 CHD4	3.79e-05	3	67	2	IPR012958
Domain	CHD_C2	CHD3 CHD4	3.79e-05	3	67	2	IPR012957
Domain	DUF1087	CHD3 CHD4	3.79e-05	3	67	2	PF06465
Domain	DUF1086	CHD3 CHD4	3.79e-05	3	67	2	PF06461
Domain	DUF1087	CHD3 CHD4	3.79e-05	3	67	2	SM01147
Domain	DUF1086	CHD3 CHD4	3.79e-05	3	67	2	SM01146
Domain	Sam68-YY	KHDRBS3 KHDRBS1	3.79e-05	3	67	2	PF16568
Domain	ACTINS_ACT_LIKE	POTEE POTEF POTEI	4.10e-05	19	67	3	PS01132
Domain	Ank_2	POTEE RNASEL POTEF CASKIN1 TRPC3 POTEI	1.21e-04	215	67	6	PF12796
Domain	GST_alpha	GSTA1 GSTA2	1.26e-04	5	67	2	IPR003080
Domain	Ank	POTEE RNASEL POTEF CASKIN1 TRPC3 POTEI	1.66e-04	228	67	6	PF00023
Domain	Actin	POTEE POTEF POTEI	1.85e-04	31	67	3	IPR004000
Domain	Actin	POTEE POTEF POTEI	1.85e-04	31	67	3	PF00022
Domain	ACTIN	POTEE POTEF POTEI	1.85e-04	31	67	3	SM00268
Domain	-	POTEE RNASEL POTEF CASKIN1 TRPC3 POTEI	2.62e-04	248	67	6	1.25.40.20
Domain	ANK	POTEE RNASEL POTEF CASKIN1 TRPC3 POTEI	2.79e-04	251	67	6	SM00248
Domain	ANK_REPEAT	POTEE RNASEL POTEF CASKIN1 TRPC3 POTEI	2.91e-04	253	67	6	PS50088
Domain	Ankyrin_rpt-contain_dom	POTEE RNASEL POTEF CASKIN1 TRPC3 POTEI	2.97e-04	254	67	6	IPR020683
Domain	ANK_REP_REGION	POTEE RNASEL POTEF CASKIN1 TRPC3 POTEI	2.97e-04	254	67	6	PS50297
Domain	Ankyrin_rpt	POTEE RNASEL POTEF CASKIN1 TRPC3 POTEI	3.51e-04	262	67	6	IPR002110
Domain	Helicase_C	DDX46 CHD3 CHD4 DICER1	5.91e-04	107	67	4	PF00271
Domain	HELICc	DDX46 CHD3 CHD4 DICER1	5.91e-04	107	67	4	SM00490
Domain	Helicase_C	DDX46 CHD3 CHD4 DICER1	6.12e-04	108	67	4	IPR001650
Domain	HELICASE_CTER	DDX46 CHD3 CHD4 DICER1	6.34e-04	109	67	4	PS51194
Domain	HELICASE_ATP_BIND_1	DDX46 CHD3 CHD4 DICER1	6.34e-04	109	67	4	PS51192
Domain	DEXDc	DDX46 CHD3 CHD4 DICER1	6.34e-04	109	67	4	SM00487
Domain	Helicase_ATP-bd	DDX46 CHD3 CHD4 DICER1	6.56e-04	110	67	4	IPR014001
Domain	P-loop_NTPase	DNHD1 NUGGC SULT1B1 DDX46 SETX CHD3 CHD4 UST DICER1 ARL5A	8.36e-04	848	67	10	IPR027417
Domain	Pept_C14_p20	CFLAR MALT1	1.12e-03	14	67	2	IPR001309
Domain	Caspase-like_dom	CFLAR MALT1	1.12e-03	14	67	2	IPR029030
Domain	CASPASE_P20	CFLAR MALT1	1.12e-03	14	67	2	PS50208
Domain	-	CFLAR MALT1	1.12e-03	14	67	2	3.40.50.1460
Domain	-	DNHD1 NUGGC SULT1B1 DDX46 SETX CHD3 CHD4 DICER1 ARL5A	1.32e-03	746	67	9	3.40.50.300
Domain	ARM-type_fold	TRPC4AP DOCK11 IFT172 TNPO2 APOB NIPBL	1.35e-03	339	67	6	IPR016024
Domain	HMG_box_dom	KMT2D CHD3 CHD4	1.64e-03	65	67	3	IPR009071
Domain	Znf_FYVE_PHD	KMT2D FGD1 CHD3 CHD4	1.92e-03	147	67	4	IPR011011
Domain	DSRM	STAU2 DICER1	2.08e-03	19	67	2	SM00358
Domain	dsrm	STAU2 DICER1	2.31e-03	20	67	2	PF00035
Domain	PHD	KMT2D CHD3 CHD4	2.48e-03	75	67	3	PF00628
Domain	DS_RBD	STAU2 DICER1	2.55e-03	21	67	2	PS50137
Domain	GST_N	GSTA1 GSTA2	2.80e-03	22	67	2	PF02798
Domain	GST_NTER	GSTA1 GSTA2	2.80e-03	22	67	2	PS50404
Domain	Znf_PHD-finger	KMT2D CHD3 CHD4	2.87e-03	79	67	3	IPR019787
Domain	Chromo_domain	CHD3 CHD4	3.33e-03	24	67	2	IPR023780
Pathway	WP_FOXA2_PATHWAY	APOB GSTA1 GSTA2	5.34e-05	21	50	3	M42579
Pathway	REACTOME_PTK6_REGULATES_PROTEINS_INVOLVED_IN_RNA_PROCESSING	KHDRBS3 KHDRBS1	1.22e-04	5	50	2	M27731
Pathway	REACTOME_PTK6_REGULATES_PROTEINS_INVOLVED_IN_RNA_PROCESSING	KHDRBS3 KHDRBS1	1.22e-04	5	50	2	MM15481
Pathway	REACTOME_RHO_GTPASE_CYCLE	POTEE NET1 DOCK11 FAM169A FGD1 TMEM87A CYFIP2 NCKAP1L	1.67e-04	450	50	8	M27078
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES	NCKIPSD CYFIP2 NCKAP1L	2.33e-04	34	50	3	MM15265
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES	NCKIPSD CYFIP2 NCKAP1L	2.76e-04	36	50	3	M27549
Pathway	REACTOME_GLUTATHIONE_CONJUGATION	GSTK1 GSTA1 GSTA2	2.76e-04	36	50	3	M1443
Pathway	REACTOME_GLUTATHIONE_CONJUGATION	GSTK1 GSTA1 GSTA2	3.25e-04	38	50	3	MM14600
Pathway	REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS	SULT1B1 GSTK1 GSTA1 GSTA2	5.52e-04	107	50	4	MM14595
Pathway	REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS	SULT1B1 GSTK1 GSTA1 GSTA2	5.92e-04	109	50	4	M18788
Pathway	KEGG_GLUTATHIONE_METABOLISM	GSTK1 GSTA1 GSTA2	7.32e-04	50	50	3	M1840
Pathway	REACTOME_RHO_GTPASE_CYCLE	NET1 DOCK11 FAM169A FGD1 TMEM87A CYFIP2 NCKAP1L	8.50e-04	439	50	7	MM15595
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	POTEE NET1 DOCK11 NCKIPSD FAM169A FGD1 TMEM87A CYFIP2 NCKAP1L	8.55e-04	720	50	9	M41838
Pubmed	Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.	SULT1B1 GSTK1 GSTA1 GSTA2	5.93e-07	34	68	4	21492153
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	POTEE KHDRBS3 KHDRBS1 GSTK1 POTEF FAM169A APOB CHD3 CHD4 POTEI NIPBL NARS2 CYFIP2 NUP205	6.29e-07	1442	68	14	35575683
Pubmed	Tissue-specific expression and subcellular distribution of murine glutathione S-transferase class kappa.	GSTK1 GSTA1 GSTA2	1.17e-06	11	68	3	15100242
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEE POTEF POTEI	3.20e-06	15	68	3	16824795
Pubmed	Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.	CHD3 CHD4	3.77e-06	2	68	2	7560064
Pubmed	Isolation of a cDNA clone and localization of human glutathione S-transferase 2 genes to chromosome band 6p12.	GSTA1 GSTA2	3.77e-06	2	68	2	3031680
Pubmed	Polymorphism of human Alpha class glutathione transferases.	GSTA1 GSTA2	3.77e-06	2	68	2	11668220
Pubmed	Human liver glutathione S-transferases: complete primary sequence of an Ha subunit cDNA.	GSTA1 GSTA2	3.77e-06	2	68	2	3800996
Pubmed	Nucleotide sequence of the human liver glutathione S-transferase subunit 1 cDNA.	GSTA1 GSTA2	3.77e-06	2	68	2	3678589
Pubmed	The basic glutathione S-transferases from human livers are products of separate genes.	GSTA1 GSTA2	3.77e-06	2	68	2	3036131
Pubmed	A primate-specific POTE-actin fusion protein plays a role in apoptosis.	POTEE POTEF	3.77e-06	2	68	2	19669888
Pubmed	The extended catalysis of glutathione transferase.	GSTA1 GSTA2	3.77e-06	2	68	2	21163259
Pubmed	Human glutathione S-transferase A2 polymorphisms: variant expression, distribution in prostate cancer cases/controls and a novel form.	GSTA1 GSTA2	3.77e-06	2	68	2	15128049
Pubmed	Genetic variation and haplotype structures of the glutathione S-transferase genes GSTA1 and GSTA2 in Japanese colorectal cancer patients.	GSTA1 GSTA2	3.77e-06	2	68	2	21844655
Pubmed	The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.	CHD3 CHD4	3.77e-06	2	68	2	7575689
Pubmed	Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression.	GSTA1 GSTA2	3.77e-06	2	68	2	11692074
Pubmed	Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.	KHDRBS3 KHDRBS1	3.77e-06	2	68	2	26758068
Pubmed	Human glutathione S-transferases. The Ha multigene family encodes products of different but overlapping substrate specificities.	GSTA1 GSTA2	3.77e-06	2	68	2	3138230
Pubmed	Heterologous expression of recombinant human glutathione transferase A1-1 from a hepatoma cell line.	GSTA1 GSTA2	3.77e-06	2	68	2	1330133
Pubmed	The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: a case-control study in the Portuguese population.	GSTA1 GSTA2	3.77e-06	2	68	2	19639209
Pubmed	Binding site density enables paralog-specific activity of SLM2 and Sam68 proteins in Neurexin2 AS4 splicing control.	KHDRBS3 KHDRBS1	3.77e-06	2	68	2	27994030
Pubmed	Characterization of two novel subunits of the alpha-class glutathione S-transferases of human liver.	GSTA1 GSTA2	3.77e-06	2	68	2	8431482
Pubmed	Salpalpha and Salpbeta, growth-arresting homologs of Sam68.	KHDRBS3 KHDRBS1	3.77e-06	2	68	2	10564820
Pubmed	Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Molecular relationships between the B1 and B2 subunits and other Alpha class glutathione S-transferases.	GSTA1 GSTA2	3.77e-06	2	68	2	2604726
Pubmed	Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development.	CHD3 CHD4	3.77e-06	2	68	2	35568926
Pubmed	Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen.	CHD3 CHD4	3.77e-06	2	68	2	8843877
Pubmed	Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.	KMT2D DICER1	3.77e-06	2	68	2	26841698
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	KMT2D SETX RNASEL FAM120A AKAP8 EBF3 CHD4 SMYD2 CYFIP2 NUP205	6.26e-06	857	68	10	25609649
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	DDX46 FAM120A AKAP8 KHDRBS1 POTEF RO60	8.53e-06	244	68	6	29884807
Pubmed	The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.	KHDRBS3 KHDRBS1	1.13e-05	3	68	2	16474851
Pubmed	Comparative expression of two alpha class glutathione S-transferases in human adult and prenatal liver tissues.	GSTA1 GSTA2	1.13e-05	3	68	2	12093480
Pubmed	Evolution and expression of chimeric POTE-actin genes in the human genome.	POTEE POTEF	1.13e-05	3	68	2	17101985
Pubmed	The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development.	CHD3 CHD4	1.13e-05	3	68	2	32658897
Pubmed	SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3' UTR Isoforms in the Nervous System.	KHDRBS3 KHDRBS1	1.13e-05	3	68	2	31805436
Pubmed	The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.	KMT2D CHD3	1.13e-05	3	68	2	26551667
Pubmed	Inhibition of HIV-1 gene expression by Sam68 Delta C: multiple targets but a common mechanism?	KHDRBS3 KHDRBS1	1.13e-05	3	68	2	19254361
Pubmed	Mapping of determinants involved in the stimulation of HIV-1 expression by Sam68.	KHDRBS3 KHDRBS1	1.13e-05	3	68	2	19091369
Pubmed	Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism.	SERPINE1 APOB	1.13e-05	3	68	2	21546607
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DDX46 SETX FAM120A AKAP8 KHDRBS3 STAU2 SERPINE1 APOB CHD3 CHD4 DICER1 NUP205	1.27e-05	1371	68	12	36244648
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	POTEE DDX46 POTEF CHD3 CHD4 POTEI	1.55e-05	271	68	6	32433965
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DDX46 SETX AKAP8 KHDRBS1 CHD3 CHD4 VPS51 NIPBL	1.79e-05	582	68	8	20467437
Pubmed	STAR, a gene family involved in signal transduction and activation of RNA.	KHDRBS3 KHDRBS1	2.25e-05	4	68	2	9433137
Pubmed	Characterization of the CHD family of proteins.	CHD3 CHD4	2.25e-05	4	68	2	9326634
Pubmed	In situ hybridization of a rat cDNA probe for glutathione S-transferase gene Ya subunit (GST Ya) to rat chromosome 8.	GSTA1 GSTA2	2.25e-05	4	68	2	1526290
Pubmed	Essential roles of ERKs and p38K in up-regulation of GST A1 expression by Maotai content in human hepatoma cell line Hep3B.	GSTA1 GSTA2	2.25e-05	4	68	2	16786188
Pubmed	Immunohistochemical localization of glutathione S-transferases in human lung.	GSTA1 GSTA2	2.25e-05	4	68	2	8242618
Pubmed	Glutathione S-transferase Ya subunit is coded by a multigene family located on a single mouse chromosome.	GSTA1 GSTA2	2.25e-05	4	68	2	6330685
Pubmed	Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes.	GSTA1 GSTA2	2.25e-05	4	68	2	8307579
Pubmed	Fibroblast growth factor-2 is required for vasa vasorum plexus stability in hypercholesterolemic mice.	SERPINE1 APOB	2.25e-05	4	68	2	22982464
Pubmed	The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.	KHDRBS3 KHDRBS1	2.25e-05	4	68	2	15471878
Pubmed	Exceptional activity of murine glutathione transferase A1-1 against (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced DNA damage in stably transfected cells.	GSTA1 GSTA2	2.25e-05	4	68	2	12557262
Pubmed	Complementary DNA cloning, messenger RNA expression, and induction of alpha-class glutathione S-transferases in mouse tissues.	GSTA1 GSTA2	2.25e-05	4	68	2	1728405
Pubmed	Glutathione S-transferase A1 (GSTA1) release, an early indicator of acute hepatic injury in mice.	GSTA1 GSTA2	2.25e-05	4	68	2	24964013
Pubmed	Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver.	GSTA1 GSTA2	2.25e-05	4	68	2	2049074
Pubmed	Glutathione S-transferase A1 - a sensitive marker of alcoholic injury on primary hepatocytes.	GSTA1 GSTA2	2.25e-05	4	68	2	27198676
Pubmed	Methyl methacrylate activates the Gsta1 promoter.	GSTA1 GSTA2	2.25e-05	4	68	2	19029078
Pubmed	SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.	KHDRBS3 KHDRBS1	2.25e-05	4	68	2	22196734
Pubmed	Mouse glutathione S-transferase Ya subunit: gene structure and sequence.	GSTA1 GSTA2	2.25e-05	4	68	2	3652905
Pubmed	NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.	CHD3 CHD4	2.25e-05	4	68	2	16574654
Pubmed	Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu, and pi expression in gastrointestinal tract mucosa of normal individuals.	GSTA1 GSTA2	2.25e-05	4	68	2	12139976
Pubmed	Cloning, expression, and biochemical characterization of a functionally novel alpha class glutathione S-transferase with exceptional activity in the glutathione conjugation of (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene.	GSTA1 GSTA2	2.25e-05	4	68	2	9606968
Pubmed	5'-flanking sequence of mouse glutathione S-transferase Ya gene.	GSTA1 GSTA2	2.25e-05	4	68	2	2893339
Pubmed	Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress.	GSTA1 GSTA2	3.75e-05	5	68	2	12020353
Pubmed	Protein depletion and refeeding change the proportion of mouse liver glutathione S-transferase subunits.	GSTA1 GSTA2	3.75e-05	5	68	2	9268051
Pubmed	Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole.	GSTA1 GSTA2	3.75e-05	5	68	2	3417659
Pubmed	Expression pattern of GSTP1 and GSTA1 in the pathogenesis of asthma.	GSTA1 GSTA2	3.75e-05	5	68	2	23647087
Pubmed	Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.	KHDRBS3 KHDRBS1	3.75e-05	5	68	2	10077576
Pubmed	Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis.	GSTA1 GSTA2	3.75e-05	5	68	2	23650189
Pubmed	Hybridization of alpha class subunits generating a functional glutathione transferase A1-4 heterodimer.	GSTA1 GSTA2	3.75e-05	5	68	2	11851347
Pubmed	Transcriptional regulation of the NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and copper.	GSTA1 GSTA2	3.75e-05	5	68	2	16243960
Pubmed	Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.	POTEE POTEF CFAP58 POTEI	3.88e-05	96	68	4	23580065
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	DDX46 FAM120A DOCK11 IFT172 CASKIN1 STAU2 PIP5K1C	4.01e-05	475	68	7	31040226
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DDX46 SETX AKAP8 KHDRBS3 KHDRBS1 EBF3 STAU2 CHD4 NIPBL NUP205	4.61e-05	1082	68	10	38697112
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	KHDRBS1 POTEF CHD3 CHD4 NUP205	4.87e-05	202	68	5	24639526
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	KMT2D SETX FAM120A KHDRBS1 EBF3 TNPO2 RPUSD2 CHD3 CHD4 NIPBL	5.42e-05	1103	68	10	34189442
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	KMT2D DDX46 KHDRBS1 CHD3 NUP205 DERA	5.58e-05	341	68	6	32971831
Pubmed	Dynamic expression of the RNA-binding protein Sam68 during mouse pre-implantation development.	KHDRBS3 KHDRBS1	5.62e-05	6	68	2	18321792
Pubmed	Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia.	SERPINE1 APOB	5.62e-05	6	68	2	16776623
Pubmed	Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.	CHD3 CHD4	5.62e-05	6	68	2	17626165
Pubmed	Zonal expression and activity of glutathione S-transferase enzymes in the mouse olfactory mucosa.	GSTA1 GSTA2	5.62e-05	6	68	2	14672804
Pubmed	Purification and characterization of eight glutathione S-transferase isoenzymes of hamster. Comparison of subunit composition of enzymes from liver, kidney, testis, pancreas and trachea.	GSTA1 GSTA2	5.62e-05	6	68	2	1530570
Pubmed	Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.	KHDRBS3 KHDRBS1	5.62e-05	6	68	2	12529443
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	ADNP2 CHD3 CHD4	5.74e-05	38	68	3	33283408
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	FAM120A AKAP8 KHDRBS1 CHD4 NUP205	6.55e-05	215	68	5	30462309
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	DDX46 KHDRBS1 CHD4 DICER1 NUP205	7.30e-05	220	68	5	34091597
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	POTEE DDX46 FAM120A POTEF STAU2 RO60 CHD3 CHD4 POTEI PIP5K1C	7.83e-05	1153	68	10	29845934
Pubmed	The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6.	GSTA1 GSTA2	7.86e-05	7	68	2	1427837
Pubmed	The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.	KHDRBS3 KHDRBS1	7.86e-05	7	68	2	11118435
Pubmed	Genetic mapping and systematic screening of mouse endogenously imprinted loci detected with restriction landmark genome scanning method (RLGS).	GSTA1 GSTA2	7.86e-05	7	68	2	7894162
Pubmed	Developmental changes in the cellular distribution of glutathione and glutathione S-transferases in the murine nervous system.	GSTA1 GSTA2	7.86e-05	7	68	2	8584275
Pubmed	Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.	KMT2D AKAP8	7.86e-05	7	68	2	23995757
Pubmed	CYP A-204C polymorphism is associated with subclinical atherosclerosis in postmenopausal women.	SERPINE1 APOB	7.86e-05	7	68	2	18665040
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	POTEE FAM120A KHDRBS1 STAU2 THAP12 DICER1	7.99e-05	364	68	6	24778252
Pubmed	A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum.	KHDRBS3 KHDRBS1 THAP12	8.94e-05	44	68	3	32492419
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DNHD1 FAM120A KHDRBS1 PNPLA8 APOB RO60 CHD4 NIPBL DICER1 CYFIP2 NUP205	9.41e-05	1425	68	11	30948266
Pubmed	The frequency of early, spontaneous miscarriage associated with the leu33pro polymorphism of Glycoprotein IIIa: a pilot study.	SERPINE1 APOB	1.05e-04	8	68	2	21039385
Pubmed	The use of restriction landmark genomic scanning to scan the mouse genome for endogenous loci with imprinted patterns of methylation.	GSTA1 GSTA2	1.05e-04	8	68	2	7774561
Pubmed	Mammalian chromodomain proteins: their role in genome organisation and expression.	CHD3 CHD4	1.05e-04	8	68	2	10655032
Pubmed	Methylenetetrahydrofolate reductase C677T polymorphism is associated with central adiposity and increased androgenicity in healthy postmenopausal women.	SERPINE1 APOB	1.05e-04	8	68	2	18728123
Pubmed	Effects of exposure in utero to bisphenol a on the expression of aryl hydrocarbon receptor, related factors, and xenobiotic metabolizing enzymes in murine embryos.	GSTA1 GSTA2	1.05e-04	8	68	2	16284450
Interaction	GAS7 interactions	KHDRBS1 NCKIPSD CYFIP2 NCKAP1L	8.02e-06	38	68	4	int:GAS7
Cytoband	2q21.1	POTEE POTEF POTEI	9.05e-05	58	68	3	2q21.1
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEE POTEF POTEI	4.62e-06	13	47	3	685
GeneFamily	Signal transduction and activation of RNA metabolism family	KHDRBS3 KHDRBS1	1.98e-05	3	47	2	1275
GeneFamily	Glutathione S-transferases	GSTK1 GSTA1 GSTA2	3.64e-05	25	47	3	567
GeneFamily	Ankyrin repeat domain containing	POTEE RNASEL POTEF CASKIN1 POTEI	4.00e-04	242	47	5	403
GeneFamily	PHD finger proteins\|NuRD complex	CHD3 CHD4	4.29e-04	12	47	2	1305
GeneFamily	PHD finger proteins	KMT2D CHD3 CHD4	1.65e-03	90	47	3	88
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2D SMYD2	3.52e-03	34	47	2	487
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Hpcal4_(Substantia_Innominata_(SI))--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	APOB TEX11 GSTA1 GSTA2	5.30e-07	43	67	4	05de4f11e7315dce19efed14605d7e1704d61b3a
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Hpcal4_(Substantia_Innominata_(SI))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	APOB TEX11 GSTA1 GSTA2	5.30e-07	43	67	4	ba1a8fd3119a26b65722898276045bf5ecf59768
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Hpcal4_(Substantia_Innominata_(SI))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	APOB TEX11 GSTA1 GSTA2	5.30e-07	43	67	4	f1e6e1c386851e773f8aa44f112ebf7fdb887df1
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	DDX46 SETX FAM120A KHDRBS1 NIPBL	1.24e-05	199	67	5	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	BAL-Severe-cDC_10\|Severe / Compartment, Disease Groups and Clusters	CFLAR MALT1 ANO9 NET1 CHD3	1.24e-05	199	67	5	54bdadd04abaf8caa948b0177c037bc089ca07e6
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	DDX46 SETX FAM120A KHDRBS1 NIPBL	1.24e-05	199	67	5	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Unfolded_protein_responsible_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	ANO9 SULT1B1 APOB GSTA1 GSTA2	1.27e-05	200	67	5	12078bc25be67180c0f4b37fef921cdcd1003576
Drug	HOCl	GSTK1 LPO APOB NARS2 GSTA1 GSTA2	1.14e-05	169	68	6	CID000024341
Drug	C14791	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID011954044
Drug	C14793	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID011954046
Drug	C14803	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID011954054
Drug	C14805	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID011954056
Drug	C14804	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID011954055
Drug	C14806	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID011954057
Drug	C14848	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID011954067
Drug	C14856	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID011954069
Drug	C14855	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID011954068
Drug	S-(2,2-dichloro-1-hydroxy)ethylglutathione	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID011954070
Drug	AC1L4MYY	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID000188517
Drug	Clch2cosg	GSTK1 GSTA1 GSTA2	2.01e-05	18	68	3	CID000163913
Drug	S-hexylglutathione	GSTK1 LPO GSTA1 GSTA2	2.21e-05	55	68	4	CID000005140
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; PC3; HT_HG-U133A	CFLAR KHDRBS1 FAM169A CHD4 IFIT2 DICER1	2.36e-05	192	68	6	4274_DN
Drug	radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT_HG-U133A	CFLAR TRPC3 SERPINE1 FGD1 CHGB TEX11	2.43e-05	193	68	6	6938_UP
Drug	Harmol hydrochloride monohydrate [40580-83-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A	MALT1 FAM169A RO60 UST NIPBL DICER1	2.50e-05	194	68	6	2900_DN
Drug	2-(S-glutathionyl) acetyl glutathione	GSTK1 GSTA1 GSTA2	2.80e-05	20	68	3	CID011954072
Drug	C14865	GSTK1 GSTA1 GSTA2	2.80e-05	20	68	3	CID011954073
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; HL60; HT_HG-U133A	CFLAR SETX RPUSD2 NIPBL DICER1 NCKAP1L	2.80e-05	198	68	6	2362_DN
Drug	cafestol	CFLAR GSTA1 GSTA2	3.26e-05	21	68	3	ctd:C053400
Drug	S-(formylmethyl)glutathione	GSTK1 GSTA1 GSTA2	4.93e-05	24	68	3	CID011954074
Drug	p-nitrobenzyl chloride	LPO GSTA1 GSTA2	4.93e-05	24	68	3	CID000007482
Drug	5-S-glutathionyl-alpha-methyldopa	GSTA1 GSTA2	5.25e-05	4	68	2	ctd:C086396
Drug	5-S-glutathionyldopamine	GSTA1 GSTA2	5.25e-05	4	68	2	ctd:C086394
Drug	AC1Q608X	GSTK1 GSTA1 GSTA2	7.91e-05	28	68	3	CID000128466
Drug	AC1L33DC	GSTK1 GSTA1 GSTA2	7.91e-05	28	68	3	CID000133757
Drug	7-chloro-DL-tryptophan	AKAP8 KHDRBS3 KHDRBS1 TNPO2	7.94e-05	76	68	4	CID000643956
Drug	Gonadotropins	GSTA1 GSTA2	8.74e-05	5	68	2	ctd:D006062
Drug	prostaglandin A2	GSTA1 GSTA2	8.74e-05	5	68	2	ctd:C100008
Drug	2-BHA	GSTK1 GSTA1 GSTA2	8.81e-05	29	68	3	CID000006932
Drug	o-dinitrobenzene	GSTK1 GSTA1 GSTA2	1.08e-04	31	68	3	CID000010707
Drug	Dcvg	GSTK1 GSTA1 GSTA2	1.08e-04	31	68	3	CID006437359
Drug	2-allylphenol	GSTA1 GSTA2	1.31e-04	6	68	2	ctd:C099328
Drug	isomethyleugenol	GSTA1 GSTA2	1.31e-04	6	68	2	ctd:C031050
Drug	quercetin 3-arabinopyranoside	GSTA1 GSTA2	1.31e-04	6	68	2	ctd:C428865
Drug	1,2-dichloro-4-nitrobenzene	GSTA1 GSTA2	1.31e-04	6	68	2	ctd:C028328
Drug	m-toluidine	GSTK1 GSTA1 GSTA2	1.43e-04	34	68	3	CID000007934
Drug	Lyndiol	GSTK1 GSTA1 GSTA2	1.43e-04	34	68	3	CID000082149
Drug	9,12,15-octadecatrienoic acid	AMPD1 SERPINE1 PNPLA8 APOB VPS51	1.44e-04	167	68	5	CID000000860
Drug	dimethoxystrychnine	GSTK1 GSTA1 GSTA2	1.56e-04	35	68	3	CID000009649
Drug	Dixan	GSTK1 GSTA1 GSTA2	1.56e-04	35	68	3	CID000010404
Drug	Glutathione	GSTK1 GSTA1 GSTA2	1.70e-04	36	68	3	DB00143
Drug	palmidrol	APOB GSTA1	1.83e-04	7	68	2	ctd:C005958
Drug	6,7-dimethylpterin	AMPD1 RPUSD2	1.83e-04	7	68	2	CID005355290
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	CFLAR TNPO2 FAM169A IFIT2 DICER1	2.04e-04	180	68	5	5981_DN
Disease	familial combined hyperlipidemia (is_marker_for)	SERPINE1 APOB	7.35e-05	6	66	2	DOID:13809 (is_marker_for)
Disease	lymphoma (is_implicated_in)	MALT1 CHD4	7.35e-05	6	66	2	DOID:0060058 (is_implicated_in)
Disease	1,3,7-trimethylurate measurement	GSTA1 GSTA2	5.08e-04	15	66	2	EFO_0021172
Disease	amenorrhea, response to antineoplastic agent	APOB DERA	5.08e-04	15	66	2	EFO_0010269, GO_0097327
Disease	Behcet Syndrome	SERPINE1 APOB	1.32e-03	24	66	2	C0004943
Disease	coronary artery disease (is_implicated_in)	AMPD1 SERPINE1 APOB	1.48e-03	100	66	3	DOID:3393 (is_implicated_in)
Disease	malaria	KLHL3 NUGGC STAU2	1.57e-03	102	66	3	EFO_0001068
Disease	Sezary Syndrome	KMT2D CHD3	1.67e-03	27	66	2	C0036920

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLKRLRINMEAKHPF	C21orf62	121	Q9NYP8
LYKMLAHEDLRKAGL	ARL5A	106	Q9Y689
HIVKMLEKYLKGEDP	AKAP8	531	O43823
HYKDMIIPKLVDDLG	ACOT6	266	Q3I5F7
LKELFAKLKMHPYDL	AMPD1	341	P23109
KLHLILKAPGMDDAA	DNHD1	3301	Q96M86
LMKDGVFEARFPLHK	ANO9	141	A1A5B4
PDAHEGRLSYMRSKK	DICER1	1336	Q9UPY3
KRPLLDLHIELNGYM	CFLAR	436	O15519
NRHLGKKKLPMDYSN	ADNP2	791	Q6IQ32
MAEKPKLHYFNARGR	GSTA1	1	P08263
HAAELRDFKNKMLPL	OLFML3	51	Q9NRN5
HLMLLIGELYKKNPF	NUP205	441	Q92621
EDLKLARKAYHDPML	NET1	191	Q7Z628
KRGILTLKYPMEHGI	POTEF	761	A5A3E0
DIKDNKGMRPLHYAA	CASKIN1	76	Q8WXD9
DRKHFLYGDPRKVMT	MAGEB18	231	Q96M61
LLIGNMNYREHPKLK	MALT1	346	Q9UDY8
VGYMKHLDRDPEKLT	NLRP11	526	P59045
KLYMELKHVLARQPG	CFAP58	756	Q5T655
AALLPSLKAEYKMGR	KIAA1109	2991	Q2LD37
MAEKPKLHYSNIRGR	GSTA2	1	P09210
FRDYLPILLGDHMQK	LPO	426	P22079
KQYLDFKLLMEHLDP	NIPBL	2616	Q6KC79
LGQMVLEYDHPLKKL	NCKAP1L	176	P55160
LRVAEHRHKKGLMYP	FAM120A	556	Q9NZB2
MKRLEAKYAPLHLVP	CYFIP2	1071	Q96F07
KLYDDMIRLVGKHHP	IFT172	1011	Q9UG01
LDIQMKLPGKFRRAH	THAP12	546	O43422
KRGILTLKYPMEHGI	POTEE	761	Q6S8J3
DASPGDKRLAAYLML	APOB	551	P04114
PGELIKYLKCLHAME	DOCK11	846	Q5JSL3
GPHMLRRLKADVFKN	CHD3	961	Q12873
RKGLYMANDLKLLRH	GSTK1	61	Q9Y2Q3
RKKYRGKDFGLHMLE	FAM169A	186	Q9Y6X4
MYGKRKLLELIGHAV	IFIT2	306	P09913
ELRKGGDPKYAHLNM	KHDRBS1	211	Q07666
YARMGHALEEIKKFL	KHDRBS3	141	O75525
KDFLIEAMKYHLLPL	KLHL3	266	Q9UH77
HADGLLKDLMRASYP	DDX46	631	Q7L014
KRAADLVEALYGMPH	EBF3	381	Q9H4W6
GPHMLRRLKADVFKN	CHD4	951	Q14839
KYPIREDLLKALNMH	DERA	76	Q9Y315
YMKLLLPDDEKFHGG	INPP5F	606	Q9Y2H2
KRNYPSLELDKMAHG	CHGB	386	P05060
DKGMAPALRHLYKEL	SERPINE1	91	P05121
HMPLDECEELYRKLG	PNPLA8	496	Q9NP80
PQDLVMFLHALRYKG	RPUSD2	511	Q8IZ73
MDKLHLPEYLRERKA	NUGGC	356	Q68CJ6
LLQRMEHSKKYPGFL	TRPC4AP	711	Q8TEL6
KYHRELKKRQPLMGD	LRTM2	341	Q8N967
FIAPGQKDRLEHMLK	NARS2	301	Q96I59
MHKEAEFLQKLLPGY	PIP5K1C	191	O60331
ERMHKLLKVYELLGG	FGD1	566	P98174
ALKDLHRIYRPMIGK	RNASEL	346	Q05823
LEKGKLILLPSHMYD	SETX	216	Q7Z333
KRGILTLKYPMEHGI	POTEI	761	P0CG38
GVHPAIALREYRKKM	RO60	476	P10155
DILRKDLKLVHGYPM	SULT1B1	6	O43704
HIADLSPGDKLRMEY	NCKIPSD	646	Q9NZQ3
LSIYKDPEHRKLGNM	UST	306	Q9Y2C2
APERRRKAHGMLKLY	VPS51	26	Q9UID3
YKLLNERGPAHSKMF	STAU2	26	Q9NUL3
SPKDDLRDMFYKILH	TNPO2	851	O14787
HGKVEMLLYAVPLLK	ZNF840P	6	A6NDX5
AMEKPAHYPLIALKA	TEX11	781	Q8IYF3
LKLGRLYMGLEHKAA	SMYD2	386	Q9NRG4
LYMGLEHKAAGEKAL	SMYD2	391	Q9NRG4
FMHRLPLLGEKQEAK	TMEM87A	141	Q8NBN3
MLLMKGARIERPHDY	TRPC3	166	Q13507
KEADMLRLFPEYLKG	KMT2D	5276	O14686