Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	HRC CACNA1B FLG HRNR FLG2	4.18e-04	749	18	5	GO:0005509
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1B CATSPER1	7.76e-04	46	18	2	GO:0005245
GeneOntologyMolecularFunction	Hsp70 protein binding	DNAJB12 DNAJB14	1.45e-03	63	18	2	GO:0030544
GeneOntologyBiologicalProcess	establishment of skin barrier	FLG HRNR FLG2	5.83e-06	41	18	3	GO:0061436
GeneOntologyBiologicalProcess	cellular response to misfolded protein	DNAJB12 DNAJB14	1.22e-04	19	18	2	GO:0071218
GeneOntologyBiologicalProcess	response to misfolded protein	DNAJB12 DNAJB14	1.50e-04	21	18	2	GO:0051788
GeneOntologyBiologicalProcess	skin epidermis development	FLG HRNR FLG2	3.82e-04	166	18	3	GO:0098773
GeneOntologyBiologicalProcess	chaperone cofactor-dependent protein refolding	DNAJB12 DNAJB14	4.21e-04	35	18	2	GO:0051085
GeneOntologyBiologicalProcess	'de novo' post-translational protein folding	DNAJB12 DNAJB14	5.78e-04	41	18	2	GO:0051084
GeneOntologyBiologicalProcess	'de novo' protein folding	DNAJB12 DNAJB14	7.28e-04	46	18	2	GO:0006458
GeneOntologyCellularComponent	keratohyalin granule	FLG HRNR FLG2	5.35e-09	5	18	3	GO:0036457
GeneOntologyCellularComponent	cornified envelope	FLG HRNR FLG2	2.71e-05	69	18	3	GO:0001533
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1B CATSPER1	7.09e-04	46	18	2	GO:0005891
GeneOntologyCellularComponent	calcium channel complex	CACNA1B CATSPER1	1.77e-03	73	18	2	GO:0034704
Domain	Filaggrin	FLG FLG2	8.77e-07	2	18	2	IPR003303
Domain	S100_CABP	FLG HRNR FLG2	2.17e-06	27	18	3	PS00303
Domain	S_100	FLG HRNR FLG2	2.17e-06	27	18	3	PF01023
Domain	S_100	FLG HRNR FLG2	2.43e-06	28	18	3	SM01394
Domain	S100_Ca-bd_sub	FLG HRNR FLG2	2.43e-06	28	18	3	IPR013787
Domain	S100/CaBP-9k_CS	FLG HRNR FLG2	2.43e-06	28	18	3	IPR001751
Domain	DUF1977	DNAJB12 DNAJB14	2.63e-06	3	18	2	PF09320
Domain	DUF1977_DnaJ-like	DNAJB12 DNAJB14	2.63e-06	3	18	2	IPR015399
Domain	EF_HAND_2	CACNA1B FLG HRNR FLG2	6.09e-05	231	18	4	PS50222
Domain	EF_hand_dom	CACNA1B FLG HRNR FLG2	6.19e-05	232	18	4	IPR002048
Domain	EF-hand-dom_pair	CACNA1B FLG HRNR FLG2	1.41e-04	287	18	4	IPR011992
Domain	DnaJ_domain_CS	DNAJB12 DNAJB14	3.04e-04	27	18	2	IPR018253
Domain	EF_Hand_1_Ca_BS	FLG HRNR FLG2	5.95e-04	175	18	3	IPR018247
Domain	EF_HAND_1	FLG HRNR FLG2	9.28e-04	204	18	3	PS00018
Domain	DnaJ	DNAJB12 DNAJB14	9.64e-04	48	18	2	PF00226
Domain	DnaJ	DNAJB12 DNAJB14	1.00e-03	49	18	2	SM00271
Domain	DNAJ_1	DNAJB12 DNAJB14	1.00e-03	49	18	2	PS00636
Domain	DNAJ_2	DNAJB12 DNAJB14	1.00e-03	49	18	2	PS50076
Domain	-	DNAJB12 DNAJB14	1.00e-03	49	18	2	1.10.287.110
Domain	DnaJ_domain	DNAJB12 DNAJB14	1.09e-03	51	18	2	IPR001623
Domain	Channel_four-helix_dom	CACNA1B CATSPER1	1.36e-03	57	18	2	IPR027359
Domain	-	CACNA1B CATSPER1	1.36e-03	57	18	2	1.20.120.350
Domain	-	FLG HRNR FLG2	1.88e-03	261	18	3	1.10.238.10
Domain	Ion_trans_dom	CACNA1B CATSPER1	5.30e-03	114	18	2	IPR005821
Domain	Ion_trans	CACNA1B CATSPER1	5.30e-03	114	18	2	PF00520
Domain	RRM_1	SPEN RBMXL3	1.68e-02	208	18	2	PF00076
Domain	RRM	SPEN RBMXL3	1.82e-02	217	18	2	SM00360
Domain	RRM_dom	SPEN RBMXL3	1.98e-02	227	18	2	IPR000504
Domain	RRM	SPEN RBMXL3	2.03e-02	230	18	2	PS50102
Domain	-	SPEN RBMXL3	2.27e-02	244	18	2	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	SPEN RBMXL3	2.51e-02	258	18	2	IPR012677
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG HRNR FLG2	1.16e-10	3	18	3	23403047
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG HRNR FLG2	1.54e-07	21	18	3	19601998
Pubmed	Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.	FLG HRNR	2.53e-07	2	18	2	27678121
Pubmed	Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure.	DNAJB12 DNAJB14	2.53e-07	2	18	2	24732912
Pubmed	DNAJB12 and DNJB14 are non-redundant Hsp40 redox chaperones involved in endoplasmic reticulum protein reflux.	DNAJB12 DNAJB14	2.53e-07	2	18	2	37925033
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	2.53e-07	2	18	2	24813994
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	7.59e-07	3	18	2	32437351
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	7.59e-07	3	18	2	28928464
Pubmed	Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins.	DNAJB12 DNAJB14	1.52e-06	4	18	2	27916661
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	FLG FLG2	3.79e-06	6	18	2	27304082
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	SPEN FLG HRNR DDX42 FLG2	1.11e-05	605	18	5	28977666
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SPEN FLG NAA40 HRNR DDX42 FLG2	1.20e-05	1082	18	6	38697112
Pubmed	TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.	FLG HRNR FLG2	1.37e-05	91	18	3	34445801
Pubmed	LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1.	FLG HRNR	1.66e-05	12	18	2	31406141
Pubmed	Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.	CACNA1B BSN	2.29e-05	14	18	2	21228161
Pubmed	PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.	FLG HRNR	2.29e-05	14	18	2	29178343
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	HRNR FLG2	3.02e-05	16	18	2	31823782
Pubmed	In Vitro Identification of Histatin 5 Salivary Complexes.	FLG HRNR	8.81e-05	27	18	2	26544073
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	SPEN TBX19 FLG ENAH HRNR	1.41e-04	1031	18	5	16710414
Pubmed	Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes.	FLG HRNR	1.58e-04	36	18	2	31669268
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	SPEN CACNA1B BSN	1.61e-04	208	18	3	33230847
Pubmed	A functional reference map of the RNF8 interactome in cancer.	FLG HRNR FLG2	1.85e-04	218	18	3	35831895
Pubmed	Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.	HRNR FLG2	2.36e-04	44	18	2	31273033
Pubmed	DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.	FLG HRNR FLG2	2.39e-04	238	18	3	35864588
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	FLG HRNR FLG2	2.61e-04	245	18	3	35652658
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	DNAJB12 DNAJB14 HRNR FLG2	2.95e-04	647	18	4	26618866
Pubmed	EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.	HRNR FLG2	3.56e-04	54	18	2	35474131
Pubmed	Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.	FLG HRNR	3.83e-04	56	18	2	37059927
Pubmed	KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.	FLG HRNR FLG2	3.89e-04	281	18	3	26725010
Pubmed	PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2.	ENAH HRNR FLG2	4.27e-04	290	18	3	32929329
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	HRNR FLG2	4.70e-04	62	18	2	26644517
Pubmed	Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.	FLG HRNR	4.70e-04	62	18	2	28344315
Pubmed	Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.	HRNR FLG2	5.00e-04	64	18	2	36636478
Pubmed	Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).	HRNR FLG2	5.16e-04	65	18	2	32120844
Interaction	DSG1 interactions	FLG NAA40 HRNR FLG2	1.86e-05	184	18	4	int:DSG1
Interaction	PRPF40A interactions	SPEN NAA40 CCNL1 ENAH DDX42	3.50e-05	446	18	5	int:PRPF40A
Interaction	SAMD12 interactions	FLG HRNR	5.84e-05	13	18	2	int:SAMD12
Interaction	DPRX interactions	HRNR FLG2	1.14e-04	18	18	2	int:DPRX
Interaction	CHD4 interactions	SPEN FLG NAA40 HRNR DDX42 FLG2	1.15e-04	938	18	6	int:CHD4
Interaction	FLG2 interactions	FLG HRNR FLG2	1.28e-04	112	18	3	int:FLG2
Interaction	FAM76A interactions	CCNL1 DDX42	1.57e-04	21	18	2	int:FAM76A
Cytoband	1q21.3	FLG HRNR FLG2	1.28e-05	117	18	3	1q21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	FLG HRNR FLG2	5.00e-04	404	18	3	chr1q21
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	NAA40 CATSPER1	1.34e-02	454	18	2	chr11q13
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG HRNR FLG2	1.99e-08	7	16	3	1350
GeneFamily	EF-hand domain containing	CACNA1B FLG HRNR FLG2	3.40e-05	219	16	4	863
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJB12 DNAJB14	8.43e-04	49	16	2	584
GeneFamily	RNA binding motif containing	SPEN RBMXL3	1.49e-02	213	16	2	725
Coexpression	GSE13484_UNSTIM_VS_3H_YF17D_VACCINE_STIM_PBMC_UP	SPEN DNAJB14 NAA40 DDX42	9.08e-06	199	18	4	M3257
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1B PKHD1L1 L3MBTL4	3.59e-05	162	18	3	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKHD1L1 L3MBTL4 BSN	5.00e-05	181	18	3	cc77ac0e223e012767222e45c5dcadc246d1aa7c
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKHD1L1 L3MBTL4 BSN	5.00e-05	181	18	3	b0fff0defba9aea6fba36e378b05a59986e2573a
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKHD1L1 L3MBTL4 BSN	5.00e-05	181	18	3	ecd52f33841f4e9d946a4edad0d58da9b0cc5ffa
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CACNA1B PKHD1L1 CATSPER1	5.33e-05	185	18	3	0ca99fcbd30c454bcdc2aa5265a0e4dba25666ea
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CACNA1B PKHD1L1 CATSPER1	5.33e-05	185	18	3	0f722ffcc3e78d5c6b1b79d31d00929801a993f1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Hematopoietic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CACNA1B PKHD1L1 CATSPER1	5.33e-05	185	18	3	c985a4b184d382a79aaff07f81c0efede2c2d493
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CACNA1B PKHD1L1 CATSPER1	5.33e-05	185	18	3	d0d0e000ebe1fc35a987930ceaf7e3369e0c694c
Disease	smoking cessation	DNAJB12 CCNL1 BSN	8.03e-04	325	17	3	EFO_0004319
Disease	epilepsy (implicated_via_orthology)	CACNA1B BSN	3.91e-03	163	17	2	DOID:1826 (implicated_via_orthology)
Disease	R-warfarin measurement	CACNA1B L3MBTL4	1.00e-02	265	17	2	EFO_0803324
Disease	childhood onset asthma	FLG HRNR	1.55e-02	334	17	2	MONDO_0005405
Disease	vitamin D measurement	FLG HRNR	1.57e-02	336	17	2	EFO_0004631

Protein segments in the cluster

Peptide	Gene	Start	Entry
RDGRRHHDGSQYGGF	CATSPER1	121	Q8NEC5
GSSRGGRQGYHHEHS	FLG	2791	P20930
GRQGYHHEHSVDSSG	FLG	2796	P20930
SSRGGRQGYHHEHSV	FLG	3116	P20930
SKHHGGSRSGHGRHR	CCNL1	511	Q9UK58
SSGGRARHSYHHPDQ	CACNA1B	2321	Q00975
GQRGDTTRHGHSGHG	FLG2	1316	Q5D862
HGHSGHGQSTQRGSR	FLG2	1401	Q5D862
SGGSHRPHSREHTYG	FLG2	1586	Q5D862
GYSGVSHTHSGHTHG	FLG2	1736	Q5D862
GHSGFSQRPHSRGHT	FLG2	1811	Q5D862
RHGHSGHGQSTQRGS	FLG2	2006	Q5D862
GVSHTHSGHTYGQAR	FLG2	2116	Q5D862
HSGHTYGQARSQHGE	FLG2	2121	Q5D862
RHGDHGRHSGRHTGE	BSN	3646	Q9UPA5
GHRHGENRHGGSAGR	DDX42	856	Q86XP3
HGSGSSHSSGYRKHG	HRNR	716	Q86YZ3
HGSASGHFSSQGRHG	HRNR	831	Q86YZ3
RHGAGSGQSLSHGRH	HRNR	2761	Q86YZ3
GIGHIRGPRYSGHHS	L3MBTL4	386	Q8NA19
RRTKFGDSHHSHAGG	NAA40	216	Q86UY6
GRAGYSQQHQHRHSG	DNAJB14	221	Q8TBM8
ARHGHGHGDFHRGFE	DNAJB12	181	Q9NXW2
AGGSTGFSRVHIYHH	ENAH	26	Q8N8S7
EHGGQARGHRGHGSE	HRC	126	P23327
STEYGHQAHRHRGHG	HRC	206	P23327
HSAYGHHERGTGGFD	SPEN	146	Q96T58
HHERGTGGFDRTRHY	SPEN	151	Q96T58
SHGRSHRYGGGGRYE	RBMXL3	936	Q8N7X1
EHGSSYIRGCAFHHG	PKHD1L1	3331	Q86WI1
HHGCEHYSGLRGHRQ	TBX19	276	O60806