Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN5 ANO6 CLCN4	2.19e-07	11	23	3	GO:0005247
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	CLCN5 ANO6 CLCN4	8.98e-07	17	23	3	GO:0008308
GeneOntologyMolecularFunction	monoatomic ion channel activity	CLCN5 TRPM3 ANO6 TRPA1 SCN9A CLCN4	1.03e-05	459	23	6	GO:0005216
GeneOntologyMolecularFunction	channel activity	CLCN5 TRPM3 ANO6 TRPA1 SCN9A CLCN4	2.21e-05	525	23	6	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CLCN5 TRPM3 ANO6 TRPA1 SCN9A CLCN4	2.24e-05	526	23	6	GO:0022803
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	RDH16 HSD17B6	3.54e-05	8	23	2	GO:0047023
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	RDH16 HSD17B6	4.55e-05	9	23	2	GO:0047044
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CLCN5 ANO6 TRPA1 CLCN4	5.16e-05	182	23	4	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CLCN5 ANO6 TRPA1 CLCN4	5.39e-05	184	23	4	GO:0022832
GeneOntologyMolecularFunction	chloride channel activity	CLCN5 ANO6 CLCN4	1.28e-04	86	23	3	GO:0005254
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CLCN5 TRPM3 ANO6 TRPA1 SCN9A CLCN4	1.70e-04	758	23	6	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CLCN5 TRPM3 ANO6 TRPA1 SCN9A CLCN4	2.18e-04	793	23	6	GO:0015075
GeneOntologyMolecularFunction	monoatomic anion channel activity	CLCN5 ANO6 CLCN4	2.19e-04	103	23	3	GO:0005253
GeneOntologyMolecularFunction	transmembrane transporter activity	CLCN5 SLC44A4 TRPM3 ANO6 TRPA1 SCN9A CLCN4	2.62e-04	1180	23	7	GO:0022857
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	RDH16 HSD17B6	3.45e-04	24	23	2	GO:0004745
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	CLCN5 ANO6 CLCN4	3.87e-04	125	23	3	GO:0015108
GeneOntologyMolecularFunction	alcohol dehydrogenase (NAD+) activity	RDH16 HSD17B6	4.06e-04	26	23	2	GO:0004022
GeneOntologyMolecularFunction	transporter activity	CLCN5 SLC44A4 TRPM3 ANO6 TRPA1 SCN9A CLCN4	4.50e-04	1289	23	7	GO:0005215
GeneOntologyMolecularFunction	antiporter activity	CLCN5 SLC44A4 CLCN4	5.17e-04	138	23	3	GO:0015297
GeneOntologyMolecularFunction	gated channel activity	CLCN5 ANO6 TRPA1 CLCN4	5.29e-04	334	23	4	GO:0022836
GeneOntologyMolecularFunction	alcohol dehydrogenase [NAD(P)+] activity	RDH16 HSD17B6	5.41e-04	30	23	2	GO:0018455
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPM3 ANO6 TRPA1 SCN9A	5.85e-04	343	23	4	GO:0005261
GeneOntologyMolecularFunction	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	RDH16 HSD17B6	6.56e-04	33	23	2	GO:0033764
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	CLCN5 ANO6 CLCN4	6.72e-04	151	23	3	GO:0008509
GeneOntologyMolecularFunction	steroid dehydrogenase activity	RDH16 HSD17B6	9.16e-04	39	23	2	GO:0016229
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	CLCN5 ANO6 CLCN4	9.63e-04	171	23	3	GO:0015103
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	CLCN5 SLC44A4 CLCN4	4.58e-03	296	23	3	GO:0015291
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	TRPM3 ANO6 TRPA1 SCN9A	6.48e-03	664	23	4	GO:0008324
GeneOntologyMolecularFunction	electron transfer activity	RDH16 HSD17B6	8.89e-03	124	23	2	GO:0009055
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	RDH16 HSD17B6	9.30e-03	127	23	2	GO:0016616
GeneOntologyMolecularFunction	calcium channel activity	TRPM3 TRPA1	9.59e-03	129	23	2	GO:0005262
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH-OH group of donors	RDH16 HSD17B6	1.09e-02	138	23	2	GO:0016614
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	ANO6 TRPA1	1.12e-02	140	23	2	GO:0099094
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPM3 TRPA1	1.30e-02	151	23	2	GO:0015085
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPM3 TRPA1 SCN9A	1.57e-02	465	23	3	GO:0046873
GeneOntologyMolecularFunction	active transmembrane transporter activity	CLCN5 SLC44A4 CLCN4	1.68e-02	477	23	3	GO:0022804
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ANO6 TRPA1	2.06e-02	193	23	2	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	ANO6 TRPA1	2.14e-02	197	23	2	GO:0022834
GeneOntologyBiologicalProcess	monoatomic anion transport	CLCN5 ANO6 TRPA1 CLCN4	4.65e-05	183	23	4	GO:0006820
GeneOntologyBiologicalProcess	negative regulation of action potential	CNR1 SCN9A	5.32e-05	10	23	2	GO:0045759
GeneOntologyBiologicalProcess	regulation of action potential	CNR1 TRPA1 SCN9A	9.76e-05	81	23	3	GO:0098900
GeneOntologyBiologicalProcess	lipid biosynthetic process	RDH16 SLC44A4 HSD17B6 PGAP1 CERS3 MOGAT1	2.09e-04	813	23	6	GO:0008610
GeneOntologyBiologicalProcess	chloride transmembrane transport	CLCN5 ANO6 CLCN4	2.55e-04	112	23	3	GO:1902476
GeneOntologyCellularComponent	endoplasmic reticulum membrane	RDH16 XK ERMP1 PGAP1 CERS3 SPPL2A HAS2 MOGAT1 CLCN4	4.77e-06	1293	23	9	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	RDH16 XK ERMP1 PGAP1 CERS3 SPPL2A HAS2 MOGAT1 CLCN4	4.96e-06	1299	23	9	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	RDH16 XK ERMP1 PGAP1 CERS3 SPPL2A HAS2 MOGAT1 CLCN4	5.90e-06	1327	23	9	GO:0042175
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	CLCN5 ANO6 NBEAL2 HSD17B6 SPPL2A CLCN4	2.37e-03	1307	23	6	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	CLCN5 ANO6 NBEAL2 HSD17B6 SPPL2A CLCN4	2.54e-03	1325	23	6	GO:0012506
GeneOntologyCellularComponent	tertiary granule membrane	ANO6 NBEAL2	2.90e-03	73	23	2	GO:0070821
MousePheno	increased chemical nociceptive threshold	TRPM3 CNR1 TRPA1 SCN9A	1.01e-07	30	21	4	MP:0008531
MousePheno	abnormal chemical nociception	TRPM3 CNR1 TRPA1 SCN9A	4.91e-07	44	21	4	MP:0002735
MousePheno	increased thermal nociceptive threshold	TRPM3 CNR1 TRPA1 SCN9A	1.82e-05	108	21	4	MP:0001973
MousePheno	abnormal thermosensation	TRPM3 TRPA1	7.69e-05	9	21	2	MP:0003663
MousePheno	abnormal thermal nociception	TRPM3 CNR1 TRPA1 SCN9A	1.03e-04	168	21	4	MP:0002733
MousePheno	hypoalgesia	TRPM3 CNR1 TRPA1 SCN9A	1.08e-04	170	21	4	MP:0003043
MousePheno	shortened PQ interval	ANO6 ERMP1	1.93e-04	14	21	2	MP:0011954
MousePheno	abnormal taste sensitivity	CNR1 TRPA1	3.62e-04	19	21	2	MP:0001986
Domain	-	CLCN5 CLCN4	5.19e-05	9	23	2	1.10.3080.10
Domain	Cl-channel_core	CLCN5 CLCN4	5.19e-05	9	23	2	IPR014743
Domain	Voltage_CLC	CLCN5 CLCN4	5.19e-05	9	23	2	PF00654
Domain	Cl-channel_volt-gated	CLCN5 CLCN4	5.19e-05	9	23	2	IPR001807
Domain	CBS	CLCN5 CLCN4	1.72e-04	16	23	2	SM00116
Domain	CBS_dom	CLCN5 CLCN4	2.72e-04	20	23	2	IPR000644
Domain	CBS	CLCN5 CLCN4	2.72e-04	20	23	2	PF00571
Domain	CBS	CLCN5 CLCN4	2.72e-04	20	23	2	PS51371
Domain	Ion_trans_dom	TRPM3 TRPA1 SCN9A	3.59e-04	114	23	3	IPR005821
Domain	Ion_trans	TRPM3 TRPA1 SCN9A	3.59e-04	114	23	3	PF00520
Domain	Sc_DH/Rdtase_CS	RDH16 HSD17B6	8.42e-04	35	23	2	IPR020904
Domain	ADH_SHORT	RDH16 HSD17B6	1.92e-03	53	23	2	PS00061
Domain	adh_short	RDH16 HSD17B6	2.07e-03	55	23	2	PF00106
Domain	SDR_fam	RDH16 HSD17B6	2.15e-03	56	23	2	IPR002347
Domain	-	RDH16 HSD17B6	1.82e-02	169	23	2	3.40.50.720
Domain	NAD(P)-bd_dom	RDH16 HSD17B6	1.90e-02	173	23	2	IPR016040
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	CLCN5 TRPM3 ANO6 TRPA1 CLCN4	1.66e-07	99	19	5	MM14910
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	CLCN5 TRPM3 ANO6 TRPA1 CLCN4	2.34e-07	106	19	5	M27200
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	CLCN5 TRPM3 ANO6 TRPA1 CLCN4	2.89e-06	176	19	5	MM15718
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	CLCN5 TRPM3 ANO6 TRPA1 CLCN4	3.50e-06	183	19	5	M997
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	CLCN5 SLC44A4 TRPM3 ANO6 TRPA1 CLCN4	1.96e-04	681	19	6	MM14985
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	CLCN5 SLC44A4 TRPM3 ANO6 TRPA1 CLCN4	3.00e-04	736	19	6	M27287
Pathway	REACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION	RDH16 HSD17B6	3.22e-04	20	19	2	MM14888
Pathway	REACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION	RDH16 HSD17B6	4.28e-04	23	19	2	M27174
Pathway	REACTOME_TRP_CHANNELS	TRPM3 TRPA1	6.37e-04	28	19	2	M27241
Pathway	REACTOME_TRP_CHANNELS	TRPM3 TRPA1	6.37e-04	28	19	2	MM14943
Pathway	WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION	TRPA1 SCN9A	1.72e-03	46	19	2	M46450
Pubmed	Identification and functional characterization of a voltage-gated chloride channel and its novel splice variant in taste bud cells.	CLCN5 CLCN4	4.18e-07	2	23	2	16129671
Pubmed	Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.	CLCN5 CLCN4	4.18e-07	2	23	2	16034421
Pubmed	TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release.	CNR1 TRPA1	1.25e-06	3	23	2	21868092
Pubmed	Evidence of evolutionary up-regulation of the single active X chromosome in mammals based on Clc4 expression levels in Mus spretus and Mus musculus.	CLCN5 CLCN4	1.25e-06	3	23	2	9256467
Pubmed	The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes.	TRPA1 SCN9A	1.25e-06	3	23	2	31285762
Pubmed	TRPM3 is a nociceptor channel involved in the detection of noxious heat.	TRPM3 TRPA1	1.25e-06	3	23	2	21555074
Pubmed	A TRP channel trio mediates acute noxious heat sensing.	TRPM3 TRPA1	1.25e-06	3	23	2	29539642
Pubmed	Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.	TRPM3 TRPA1	1.25e-06	3	23	2	25733887
Pubmed	A contravention of Ohno's law in mice.	CLCN5 CLCN4	2.51e-06	4	23	2	7670497
Pubmed	Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice.	CLCN5 CLCN4	2.51e-06	4	23	2	7670496
Pubmed	Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation.	CLCN5 CLCN4	2.51e-06	4	23	2	20351103
Pubmed	Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease.	CLCN5 CLCN4	2.51e-06	4	23	2	19546591
Pubmed	An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.	CLCN5 CLCN4	4.18e-06	5	23	2	19339555
Pubmed	The Sensory Coding of Warm Perception.	TRPM3 TRPA1	4.18e-06	5	23	2	32208171
Pubmed	Expression of CLCN voltage-gated chloride channel genes in human blood vessels.	CLCN5 CLCN4	6.26e-06	6	23	2	10198195
Pubmed	High-resolution comparative mapping of the proximal region of the mouse X chromosome.	CLCN5 XK	8.77e-06	7	23	2	8530041
Pubmed	Significant determinants of mouse pain behaviour.	TRPA1 SCN9A	1.17e-05	8	23	2	25101983
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCN5 CLCN4	1.50e-05	9	23	2	23115349
Pubmed	The IgLON family of cell adhesion molecules expressed in developing neural circuits ensure the proper functioning of the sensory system in mice.	TRPM3 TRPA1	2.29e-05	11	23	2	39349721
Pubmed	Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain.	TRPM3 HAS2	2.75e-05	12	23	2	23342162
Pubmed	Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.	TRPA1 SCN9A	3.25e-05	13	23	2	35904071
Pubmed	Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.	TRPM3 TRPA1	6.36e-05	18	23	2	31911949
Pubmed	Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.	TRPM3 TRPA1	7.89e-05	20	23	2	33789102
Pubmed	ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.	TRPA1 SCN9A	8.72e-05	21	23	2	25369838
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CLCN5 SCN9A CLCN4	1.04e-04	139	23	3	16985003
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPM3 TRPA1	1.14e-04	24	23	2	33884443
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPM3 TRPA1	1.24e-04	25	23	2	16382100
Pubmed	An introduction to TRP channels.	TRPM3 TRPA1	1.45e-04	27	23	2	16460286
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPM3 TRPA1	2.18e-04	33	23	2	19834762
Pubmed	A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation.	CLCN5 XK	2.32e-04	34	23	2	10857745
Pubmed	Ion channel expression in the developing enteric nervous system.	CLCN5 CLCN4	2.75e-04	37	23	2	25798587
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPM3 TRPA1	3.89e-04	44	23	2	19322198
Cytoband	12q13.3	RDH16 NEMP1	3.02e-04	51	23	2	12q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	RDH16 NEMP1 HSD17B6	1.20e-03	423	23	3	chr12q13
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	TMEM249 HAS2	1.36e-02	355	23	2	chr8q24
GeneFamily	Chloride voltage-gated channels	CLCN5 CLCN4	3.73e-05	10	17	2	302
GeneFamily	Transient receptor potential cation channels	TRPM3 TRPA1	3.10e-04	28	17	2	249
GeneFamily	Short chain dehydrogenase/reductase superfamily	RDH16 HSD17B6	2.28e-03	76	17	2	743
Drug	menthol	TRPM3 CNR1 HAS2 TRPA1	1.67e-06	87	23	4	CID000001254
Drug	Heparin Heptasaccharide	CLCN5 MAS1 CLCN4	1.01e-05	42	23	3	CID005289052
Drug	4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile	RDH16 HSD17B6 MOGAT1	2.28e-05	55	23	3	ctd:C575631
Disease	Dent disease (implicated_via_orthology)	CLCN5 CLCN4	1.74e-06	3	23	2	DOID:0050699 (implicated_via_orthology)
Disease	osteopetrosis (implicated_via_orthology)	CLCN5 CLCN4	1.22e-05	7	23	2	DOID:13533 (implicated_via_orthology)
Disease	migraine disorder, Headache	RDH16 NEMP1 HSD17B6	4.06e-05	86	23	3	HP_0002315, MONDO_0005277
Disease	diabetic neuropathy (implicated_via_orthology)	CNR1 TRPA1	5.26e-05	14	23	2	DOID:9743 (implicated_via_orthology)
Disease	Etat Marbre	XK CNR1	1.46e-04	23	23	2	C0266487
Disease	Movement Disorders	XK CNR1	2.33e-04	29	23	2	C0026650
Disease	Pain, Migratory	CNR1 TRPA1	6.68e-04	49	23	2	C0751407
Disease	Suffering, Physical	CNR1 TRPA1	6.68e-04	49	23	2	C0751408
Disease	Radiating pain	CNR1 TRPA1	6.68e-04	49	23	2	C0234254
Disease	Pain, Burning	CNR1 TRPA1	6.68e-04	49	23	2	C0234230
Disease	Ache	CNR1 TRPA1	6.68e-04	49	23	2	C0234238
Disease	Pain, Crushing	CNR1 TRPA1	6.68e-04	49	23	2	C0458259
Disease	Pain, Splitting	CNR1 TRPA1	6.68e-04	49	23	2	C0458257
Disease	Pain	CNR1 TRPA1	6.68e-04	49	23	2	C0030193
Disease	age at menarche	TRPM3 NEMP1 ERMP1 HSD17B6	1.06e-03	594	23	4	EFO_0004703
Disease	perceived unattractiveness to mosquitos measurement	RDH16 SLC44A4	1.44e-03	72	23	2	EFO_0008380

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASAYILNYLMYILWA	CLCN4	146	P51793
LGMFIPYLYALYLIW	ERMP1	586	Q7Z2K6
PYLYALYLIWAVFEM	ERMP1	591	Q7Z2K6
GIYFAWLGYYTQMLL	ANO6	296	Q4KMQ2
NYLFLYIPYLMWLYF	MOGAT1	46	Q96PD6
AMPMRLLYLLYYEYW	MAS1	241	P04201
YWQYLLSYVLTVGFM	NEMP1	246	O14524
LQVLHLYWGYYILKM	CERS3	311	Q8IU89
LYWGYYILKMLNRCI	CERS3	316	Q8IU89
MWLYLAAFVGLYYLL	HSD17B6	1	O14756
YIVNYFMYVLWALLF	CLCN5	206	P51795
TLLYACYWVMLLTLY	HAS2	516	Q92819
LLLFIVYAYMYILWK	CNR1	286	P21554
YYWLPIMTSILGAYV	SLC44A4	636	Q53GD3
MWLYLAVFVGLYYLL	RDH16	1	O75452
MAASERLYELWLLYY	NBEAL2	1	Q6ZNJ1
IFILEMLLKWIAYGY	SCN9A	1236	Q15858
MPSLIYWLKNLRYYF	PGAP1	831	Q75T13
AIAVYFYWMNFLLYL	TRPA1	836	O75762
VKFWFYTLAYIGYLM	TRPM3	896	Q9HCF6
LLYFFYKWLVYVMIA	SPPL2A	236	Q8TCT8
AVNWLGYAYLYIRML	SNRNP200	916	O75643
YYMWKRALYDGLTLV	VRTN	686	Q9H8Y1
LLLLWYLFKTDIYMY	XK	331	P51811
YYLDTLWKGMLLFII	TMEM249	56	Q2WGJ8