Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	PDE1C PDE1B	3.63e-05	3	70	2	GO:0048101
GeneOntologyMolecularFunction	calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	PDE1C PDE1B	3.63e-05	3	70	2	GO:0004117
GeneOntologyMolecularFunction	cytoskeletal protein binding	SPTBN5 STX1A AP1G1 MYO6 CLU SYNM SYNE1 ROCK1 MYH15 PLEC SKA3 CROCC KIF7	1.00e-04	1099	70	13	GO:0008092
GeneOntologyMolecularFunction	ATP-dependent activity	UBA7 MYO6 CLU DHX40 RNF213 MYH15 CHD4 KIF7 RAD50	2.83e-04	614	70	9	GO:0140657
GeneOntologyBiologicalProcess	regulation of organelle organization	RABEP2 SPTBN5 CLU ERC1 SYNE1 CDK11A ROCK1 CGNL1 ARHGAP35 SKA3 CROCC TRIM27 CIT AXIN2 RAD50 RAB11FIP3	4.48e-06	1342	67	16	GO:0033043
GeneOntologyBiologicalProcess	regulation of cellular component biogenesis	RABEP2 SPTBN5 STX1A LDB1 CLU SYNE1 IQSEC2 LRP4 ROCK1 CHD4 CGNL1 ARHGAP35 CROCC RAB11FIP3	2.29e-05	1189	67	14	GO:0044087
GeneOntologyBiologicalProcess	myelin maintenance	SH3TC2 CLU PLEC	2.58e-05	18	67	3	GO:0043217
GeneOntologyBiologicalProcess	regulation of cilium assembly	RABEP2 SYNE1 ARHGAP35 CROCC RAB11FIP3	2.67e-05	108	67	5	GO:1902017
GeneOntologyBiologicalProcess	Wnt signaling pathway	LDB1 LEO1 UBR5 CALCOCO1 LRP4 RNF213 AMER3 AMOTL2 AXIN2	4.22e-05	516	67	9	GO:0016055
GeneOntologyBiologicalProcess	vesicle-mediated transport in synapse	STX1A SNPH AP1G1 MYO6 ERC1 SYNE1 ROCK1	8.09e-05	321	67	7	GO:0099003
GeneOntologyBiologicalProcess	negative regulation of interleukin-2 production	HAVCR2 TRIM27 NR1H4	1.38e-04	31	67	3	GO:0032703
GeneOntologyCellularComponent	actin cytoskeleton	DOCK5 SPTBN5 STX1A MYO6 LAD1 ANKRD62 MYH15 CGNL1 ARHGAP35 CROCC CIT	3.14e-06	576	70	11	GO:0015629
GeneOntologyCellularComponent	microtubule organizing center	RABEP2 LEO1 ERC1 ANKRD62 ROCK1 CEP131 CHD4 ARHGAP35 SKA3 CROCC AXIN2 KIF7 RAB11FIP3	9.75e-06	919	70	13	GO:0005815
GeneOntologyCellularComponent	centrosome	RABEP2 LEO1 ERC1 ANKRD62 CEP131 CHD4 SKA3 CROCC AXIN2 RAB11FIP3	2.33e-04	770	70	10	GO:0005813
GeneOntologyCellularComponent	cell cortex region	SPTBN5 ERC1 IQSEC2	4.61e-04	45	70	3	GO:0099738
GeneOntologyCellularComponent	ciliary basal body	RABEP2 ERC1 CEP131 ARHGAP35 KIF7	4.97e-04	195	70	5	GO:0036064
Domain	PDEase_N	PDE1C PDE1B	4.14e-05	3	70	2	IPR013706
Domain	PDEase_I_N	PDE1C PDE1B	4.14e-05	3	70	2	PF08499
Domain	Actinin_actin-bd_CS	SPTBN5 SYNE1 PLEC	8.46e-05	23	70	3	IPR001589
Domain	ACTININ_2	SPTBN5 SYNE1 PLEC	8.46e-05	23	70	3	PS00020
Domain	ACTININ_1	SPTBN5 SYNE1 PLEC	8.46e-05	23	70	3	PS00019
Domain	Spectrin_repeat	SPTBN5 SYNE1 PLEC	1.72e-04	29	70	3	IPR002017
Domain	RBD-FIP	ERC1 RAB11FIP3	2.06e-04	6	70	2	PF09457
Domain	Rab-bd_FIP-RBD	ERC1 RAB11FIP3	2.06e-04	6	70	2	IPR019018
Domain	FIP_RBD	ERC1 RAB11FIP3	2.06e-04	6	70	2	PS51511
Domain	Spectrin/alpha-actinin	SPTBN5 SYNE1 PLEC	2.31e-04	32	70	3	IPR018159
Domain	SPEC	SPTBN5 SYNE1 PLEC	2.31e-04	32	70	3	SM00150
Domain	IQ	MYO6 IQSEC2 MYH15 CEP131	4.11e-04	93	70	4	PS50096
Domain	CH	SPTBN5 SYNE1 PLEC	1.86e-03	65	70	3	SM00033
Domain	Myosin_tail_1	MYH15 CGNL1	2.04e-03	18	70	2	PF01576
Domain	Myosin_tail	MYH15 CGNL1	2.04e-03	18	70	2	IPR002928
Domain	PDEase	PDE1C PDE1B	2.27e-03	19	70	2	IPR023088
Domain	CH	SPTBN5 SYNE1 PLEC	2.31e-03	70	70	3	PF00307
Domain	IQ	MYO6 IQSEC2 CEP131	2.40e-03	71	70	3	PF00612
Domain	-	SPTBN5 SYNE1 PLEC	2.40e-03	71	70	3	1.10.418.10
Domain	CH	SPTBN5 SYNE1 PLEC	2.60e-03	73	70	3	PS50021
Domain	PDEase_I	PDE1C PDE1B	2.78e-03	21	70	2	PF00233
Domain	PDEASE_I	PDE1C PDE1B	2.78e-03	21	70	2	PS00126
Domain	PDEase_CS	PDE1C PDE1B	2.78e-03	21	70	2	IPR023174
Domain	CH-domain	SPTBN5 SYNE1 PLEC	2.81e-03	75	70	3	IPR001715
Domain	-	PDE1C PDE1B	3.05e-03	22	70	2	1.10.1300.10
Domain	Spectrin	SPTBN5 SYNE1	3.33e-03	23	70	2	PF00435
Domain	PDEase_catalytic_dom	PDE1C PDE1B	3.33e-03	23	70	2	IPR002073
Domain	-	SPTBN5 IQSEC2 APBB2 ROCK1 AGAP11 CIT	3.44e-03	391	70	6	2.30.29.30
Domain	HDc	PDE1C PDE1B	3.62e-03	24	70	2	SM00471
Domain	HD/PDEase_dom	PDE1C PDE1B	3.62e-03	24	70	2	IPR003607
Domain	PH	SPTBN5 IQSEC2 ROCK1 AGAP11 CIT	3.88e-03	278	70	5	SM00233
Domain	PH_DOMAIN	SPTBN5 IQSEC2 ROCK1 AGAP11 CIT	3.94e-03	279	70	5	PS50003
Domain	PH_domain	SPTBN5 IQSEC2 ROCK1 AGAP11 CIT	4.00e-03	280	70	5	IPR001849
Domain	P-loop_NTPase	MYO6 DHX40 RNF213 MYH15 CHD4 ARHGAP35 CARD14 KIF7 RAD50	4.27e-03	848	70	9	IPR027417
Domain	IQ_motif_EF-hand-BS	MYO6 IQSEC2 CEP131	4.69e-03	90	70	3	IPR000048
Domain	PH_dom-like	SPTBN5 IQSEC2 APBB2 ROCK1 AGAP11 CIT	5.21e-03	426	70	6	IPR011993
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RABEP2 TXLNA LDB1 PDE1B UBR5 CLU ERC1 SYNE1 IQSEC2 CALCOCO1 ROCK1 CEP131 CHD4 CIT KIF7 RAD50	6.46e-11	963	70	16	28671696
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	STX1A UBA7 LDB1 LEO1 MYO6 CLU SYNM ERC1 SYNE1 IQSEC2 NEMF APBB2 LRP4 CHD4 PLEC AMOTL2 CIT	4.96e-10	1285	70	17	35914814
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PDE1C SNPH AP1G1 MYO6 CLU ERC1 SYNE1 IQSEC2 CALCOCO1 SCAPER KNDC1 CGNL1 PLEC ARHGAP35 CROCC KRT79 CIT	2.52e-09	1431	70	17	37142655
Pubmed	SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling.	RABEP2 ERC1 CEP131	3.12e-08	4	70	3	27224062
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	DOCK5 UBR5 MYO6 SYNM ANGEL1 APBB2 RNF213 CEP131 CHD4 CGNL1 SLC39A10 ANKRD50	4.62e-08	777	70	12	35844135
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	NOL4 UBR5 ERC1 CEP131 CHD4 PLEC SKA3 PALB2 RAD50	1.63e-07	418	70	9	34709266
Pubmed	Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.	ERC1 PLEC AMOTL2	2.72e-07	7	70	3	23525008
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	LEO1 UBR5 ERC1 DHX40 CDK11A UNK ROCK1 CEP131 CGNL1 RAD50	2.82e-07	588	70	10	38580884
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	NOL4 UBR5 CLU ERC1 ANGEL1 SPTLC1 SCAPER LRP4 RNF213 CHD4 TRIM27 KIF7 RAD50	3.11e-07	1116	70	13	31753913
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	TXLNA ERC1 DHX40 CDK11A ROCK1 CEP131 SKA3 PALB2 KIF7 RAD50	6.55e-07	645	70	10	25281560
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	TXLNA LEO1 SLC4A1AP MYO6 ERC1 SCAPER ROCK1 CHD4 PLEC CIT RAD50	9.80e-07	847	70	11	35235311
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SYNE1 KNDC1 UNK CGNL1 ARHGAP35	2.04e-06	102	70	5	11214970
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	SPTBN5 SYNE1 APBB2 RNF213 PLEC CROCC	2.20e-06	187	70	6	26460568
Pubmed	Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly.	STX1A SNPH	3.99e-06	2	70	2	10707983
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	CLU SYNE1 ANGEL1 APBB2 TRIM27	4.55e-06	120	70	5	31413325
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DOCK5 TXLNA LEO1 AP1G1 CLU DHX40 NEMF ANGEL1 ANKRD50	6.20e-06	650	70	9	38777146
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SH3TC2 MYO6 SYNM SCAPER ANKRD62 RNF213 CGNL1 ARHGAP35	6.73e-06	493	70	8	15368895
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	TXLNA SLC4A1AP UBR5 MYO6 CLU SYNM SYNE1 SPTLC1 CEP131 SLC39A10 TRIM27 SUCO KIF7	7.39e-06	1487	70	13	33957083
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DHX40 SYNE1 CGNL1 PLEC TRIM27 RAD50	7.96e-06	234	70	6	36243803
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	RABEP2 DOCK5 TXLNA LEO1 ERC1 IQSEC2 CDK11A POLL CEP131 PLEC KIF7 RAD50	1.19e-05	1321	70	12	27173435
Pubmed	Tau regulates the microtubule-dependent migration of glioblastoma cells via the Rho-ROCK signaling pathway.	ROCK1 ARHGAP35	1.20e-05	3	70	2	30659115
Pubmed	Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase.	PDE1C PDE1B	1.20e-05	3	70	2	9003415
Pubmed	Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.	PDE1C PDE1B	1.20e-05	3	70	2	18335582
Pubmed	Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.	PDE1C PDE1B	1.20e-05	3	70	2	7568196
Pubmed	Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.	PDE1C PDE1B	1.20e-05	3	70	2	17726023
Pubmed	A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase.	PDE1C PDE1B	1.20e-05	3	70	2	1326532
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	TXLNA LEO1 CLU SCAPER CDK11A MYH15 CHD4 PLEC AXIN2 RAD50	1.37e-05	910	70	10	36736316
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	AP1G1 UBR5 MYO6 CLU RNF213 RAD50	1.51e-05	262	70	6	36880596
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	STX1A MYO6 NUDT1 ERC1 IQSEC2 CDK11A CEP131 CHD4 AMOTL2 SUCO	1.58e-05	925	70	10	28986522
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	DOCK5 AP1G1 UBR5 ERC1 SYNE1 SPTLC1 CHD4 TRIM27 RAD50	2.02e-05	754	70	9	35906200
Pubmed	Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.	ERC1 TRIM27 CIT KIF7	2.02e-05	79	70	4	29121065
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	TXLNA LEO1 AP1G1 SLC4A1AP UBR5 ERC1 NEMF CHD4 PLEC ARHGAP35 KRT79 RAD50	2.35e-05	1415	70	12	28515276
Pubmed	Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells.	TXLNA STX1A	2.39e-05	4	70	2	12558796
Pubmed	Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signalling.	AMER3 AXIN2	2.39e-05	4	70	2	24251807
Pubmed	Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.	CHD4 TRIM27	2.39e-05	4	70	2	14530259
Pubmed	Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets.	SYNE1 CROCC	2.39e-05	4	70	2	28625779
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	LEO1 SLC4A1AP CDK11A UNK CHD4 PLEC ARHGAP35 PALB2 RAD50	2.47e-05	774	70	9	15302935
Pubmed	Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.	TXLNA UBR5 CHD4 RAD50	2.95e-05	87	70	4	24169447
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	UBR5 ERC1 UNK CEP131 AMOTL2 TRIM27 KIF7	3.25e-05	446	70	7	24255178
Pubmed	Identification and characterization of taxilin isoforms.	TXLNA STX1A	3.98e-05	5	70	2	15184072
Pubmed	Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons.	STX1A SNPH	3.98e-05	5	70	2	15459722
Pubmed	Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.	CHD4 TRIM27	3.98e-05	5	70	2	16186106
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	AP1G1 SLC4A1AP DHX40 CEP131 ARHGAP35 ANKRD50 RAD50	4.65e-05	472	70	7	38943005
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	TXLNA UBR5 ERC1 DHX40 UNK CGNL1 PLEC KIF7 RAD50	5.25e-05	853	70	9	28718761
Pubmed	NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription.	MYO6 CALCOCO1	5.96e-05	6	70	2	29187741
Pubmed	Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior.	ROCK1 ARHGAP35	5.96e-05	6	70	2	17928439
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE1 PLEC	5.96e-05	6	70	2	18827015
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	UBR5 ERC1 UNK CEP131 ARHGAP35	6.58e-05	209	70	5	36779422
Pubmed	ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.	SYNE1 ANKRD62 PLEC KRT79	8.21e-05	113	70	4	34474245
Pubmed	Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals.	PALB2 RAD50	8.33e-05	7	70	2	21356067
Pubmed	MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.	ROCK1 CIT	8.33e-05	7	70	2	29162624
Pubmed	Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18.	SYNM KRT79	8.33e-05	7	70	2	11683385
Pubmed	Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators.	CLU AMOTL2 AXIN2	8.47e-05	42	70	3	23863479
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	RABEP2 SYNM ERC1 LAD1 MMRN2 PLEC	8.86e-05	360	70	6	33111431
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	UBR5 SYNE1 MICB ANGEL1 SPTLC1 LRP4 ROCK1 TRIM27	9.80e-05	719	70	8	35337019
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	STX1A LEO1 CLU ARHGAP35 CIT	1.05e-04	231	70	5	16452087
Pubmed	ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.	CHD4 TRIM27	1.11e-04	8	70	2	32533114
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	UBR5 MYO6 ERC1 UNK CEP131 SLC39A10 CIT RAD50	1.36e-04	754	70	8	33060197
Pubmed	RhoE binds to ROCK I and inhibits downstream signaling.	ROCK1 CIT	1.42e-04	9	70	2	12773565
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	UBR5 MYO6 SPTLC1 CEP131 CHD4 RAD50	1.55e-04	399	70	6	37536630
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	UBR5 CLU SYNE1 IQSEC2 CIT	1.55e-04	251	70	5	27507650
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SNPH UBR5 ERC1 SYNE1 SLC39A10 CROCC	1.73e-04	407	70	6	12693553
Pubmed	Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.	CROCC RAB11FIP3	1.78e-04	10	70	2	12800201
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	TXLNA MYO6 SYNM ERC1 LAD1 PLEC TRIM27 KRT79 CIT RAD50	2.03e-04	1257	70	10	36526897
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	AP1G1 NEMF CDK11A RNF213 CHD4 PLEC RAD50	2.08e-04	601	70	7	33658012
Pubmed	Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.	LRP4 AXIN2	2.17e-04	11	70	2	20454682
Pubmed	MRE11 complex links RECQ5 helicase to sites of DNA damage.	UBR5 RAD50	2.17e-04	11	70	2	19270065
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	LDB1 PDE1B ERC1 PLEC	2.26e-04	147	70	4	16959763
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	UBR5 CHD4 KIF7 RAD50	2.26e-04	147	70	4	29576527
Pubmed	Global phosphoproteome of HT-29 human colon adenocarcinoma cells.	UBR5 LAD1 PLEC	2.34e-04	59	70	3	16083285
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RABEP2 LEO1 SLC4A1AP ERC1 RNF213 ROCK1 CEP131 SLC39A10 KIF7	2.49e-04	1049	70	9	27880917
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	STX1A PDE1B AP1G1 MYO6 ERC1 ROCK1 CARD14	2.53e-04	621	70	7	22794259
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	ERC1 SYNE1 CGNL1 PLEC	2.57e-04	152	70	4	34299191
Pubmed	FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development.	AP1G1 SPTLC1	2.60e-04	12	70	2	29142217
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	UBR5 SYNE1 IQSEC2 AGAP11 CIT	2.62e-04	281	70	5	28706196
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	LAD1 AMER3 PLEC TRIM27 RAD50	2.75e-04	284	70	5	29459677
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	TXLNA ERC1 SPTLC1 CEP131 KIF7	2.79e-04	285	70	5	32838362
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	CEP131 CHD4 PALB2 RAD50	2.91e-04	157	70	4	30686591
Pubmed	Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.	LDB1 AXIN2	3.07e-04	13	70	2	22819339
Pubmed	Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction.	LRP4 AXIN2	3.07e-04	13	70	2	30206360
Pubmed	Genome-wide association study of panic disorder in the Japanese population.	CLU CALCOCO1	3.07e-04	13	70	2	19165232
Pubmed	Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.	PDE1C PDE1B	3.07e-04	13	70	2	8557689
Pubmed	FAM188B enhances cell survival via interaction with USP7.	UBR5 KIF7 RAD50	3.12e-04	65	70	3	29795372
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	UBA7 LDB1 UBR5 CDK11A CHD4 TRIM27 KIF7 RAD50	3.23e-04	857	70	8	25609649
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	LEO1 SLC4A1AP CDK11A CHD4	3.35e-04	163	70	4	22113938
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	TXLNA LEO1 AP1G1 CLU SYNM NEMF ROCK1	3.43e-04	653	70	7	33742100
Pubmed	Lrp4 modulates extracellular integration of cell signaling pathways in development.	LRP4 AXIN2	3.58e-04	14	70	2	19116665
Pubmed	GATA-1 forms distinct activating and repressive complexes in erythroid cells.	LDB1 CHD4	3.58e-04	14	70	2	15920471
Pubmed	An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape.	LDB1 POLL	3.58e-04	14	70	2	23453598
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	TXLNA CEP131 PLEC KRT79 KIF7	3.64e-04	302	70	5	30561431
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	SLC4A1AP UBR5 NEMF CARD14	3.67e-04	167	70	4	25659891
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	AP1G1 KNDC1 RNF213 ROCK1 CHD4	3.76e-04	304	70	5	32235678
Pubmed	Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms.	LRP4 AXIN2	4.12e-04	15	70	2	30235284
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	STX1A CLU ERC1 IQSEC2 KNDC1 CEP131 PLEC ARHGAP35 CIT	4.55e-04	1139	70	9	36417873
Pubmed	Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4.	RNF213 AXIN2	4.71e-04	16	70	2	29859889
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	TXLNA SLC4A1AP IQSEC2 SCAPER ROCK1 CEP131 ARHGAP35	4.73e-04	689	70	7	36543142
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	UBR5 RNF213 PLEC	4.94e-04	76	70	3	27542412
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	STX1A LDB1 AP1G1 SPTLC1 SCAPER CEP131 AMOTL2 TRIM27	5.23e-04	922	70	8	27609421
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	LEO1 SLC4A1AP MYO6 DHX40 CHD4 ARHGAP35	5.49e-04	506	70	6	30890647
Pubmed	Human transcription factor protein interaction networks.	NOL4 LDB1 MYO6 DHX40 CDK11A UNK CEP131 CIT KIF7 RAD50	5.59e-04	1429	70	10	35140242
Interaction	KRT19 interactions	SYNM ERC1 CALCOCO1 POLL CEP131 CHD4 PLEC AMOTL2 KRT79 KIF7	3.49e-08	282	68	10	int:KRT19
Interaction	NDC80 interactions	TXLNA ERC1 CALCOCO1 ROCK1 CEP131 SKA3 AMOTL2 KIF7 RAD50	1.01e-06	312	68	9	int:NDC80
Interaction	KDM1A interactions	NOL4 LEO1 SLC4A1AP UBR5 CLU ERC1 UNK CEP131 CHD4 PLEC SKA3 CIT PALB2 RAD50	2.48e-06	941	68	14	int:KDM1A
Interaction	KRT16 interactions	TXLNA CALCOCO1 POLL CHD4 PLEC KRT79 KIF7	4.49e-06	197	68	7	int:KRT16
Interaction	KCTD13 interactions	PDE1C SNPH AP1G1 MYO6 CLU ERC1 SYNE1 IQSEC2 CALCOCO1 SCAPER KNDC1 CGNL1 PLEC ARHGAP35 CROCC CIT	1.19e-05	1394	68	16	int:KCTD13
Interaction	DISC1 interactions	UBR5 CLU SYNM SYNE1 ANGEL1 LRP4 TRIM27 CIT KIF7	1.34e-05	429	68	9	int:DISC1
Interaction	DYRK1A interactions	TXLNA STX1A LEO1 CLU NUDT1 ERC1 KNDC1 LRP4 CEP131 CIT	1.53e-05	552	68	10	int:DYRK1A
Interaction	NOL4L interactions	NOL4 CHD4 SKA3	1.99e-05	16	68	3	int:NOL4L
Interaction	DDX41 interactions	UBR5 DHX40 CDK11A CHD4 ANKRD50 CIT	2.05e-05	166	68	6	int:DDX41
Interaction	BICD1 interactions	UBR5 ERC1 UNK CGNL1 CIT KIF7 RAD50	2.12e-05	250	68	7	int:BICD1
Interaction	DSCAM interactions	LDB1 CLU SYNE1 PLEC AMOTL2 CIT	2.42e-05	171	68	6	int:DSCAM
Interaction	NIN interactions	TXLNA ERC1 DHX40 CEP131 CGNL1 SKA3 CIT KIF7	2.73e-05	359	68	8	int:NIN
Interaction	CDK11A interactions	LEO1 DHX40 CDK11A CHD4 CIT RAD50	3.23e-05	180	68	6	int:CDK11A
Interaction	CEP135 interactions	TXLNA SYNM ERC1 CEP131 CGNL1 TRIM27 KIF7	3.63e-05	272	68	7	int:CEP135
Interaction	PIBF1 interactions	TXLNA CEP131 AMOTL2 TRIM27 CIT KIF7	5.82e-05	200	68	6	int:PIBF1
Interaction	FAM184A interactions	CEP131 AMOTL2 TRIM27 KIF7	1.03e-04	72	68	4	int:FAM184A
Interaction	ZNF460 interactions	NOL4 IQSEC2 CDK11A CHD4 KIF7	1.03e-04	138	68	5	int:ZNF460
Interaction	RBM25 interactions	LEO1 UBR5 CDK11A CHD4 SKA3 ANKRD50 CIT	1.07e-04	323	68	7	int:RBM25
Interaction	NOLC1 interactions	RABEP2 UBR5 CDK11A RNF213 CHD4 SKA3 CIT	1.11e-04	325	68	7	int:NOLC1
Interaction	SYNE3 interactions	SYNM ERC1 UNK CEP131 CGNL1 PLEC PALB2 KIF7	1.21e-04	444	68	8	int:SYNE3
Interaction	MED4 interactions	TXLNA UBR5 ERC1 DHX40 CDK11A CEP131 SKA3 KIF7	1.33e-04	450	68	8	int:MED4
Interaction	LMNB2 interactions	LEO1 DHX40 AMOTL2 TRIM27 CIT PALB2	1.38e-04	234	68	6	int:LMNB2
Interaction	PHF21A interactions	NOL4 UBR5 ERC1 CEP131 PLEC SKA3 RAD50	1.55e-04	343	68	7	int:PHF21A
Interaction	CCDC62 interactions	PLEC CIT	1.67e-04	6	68	2	int:CCDC62
Interaction	LRRCC1 interactions	CEP131 SKA3 KIF7	1.70e-04	32	68	3	int:LRRCC1
Interaction	TOP1MT interactions	LEO1 CHD4 CIT	1.86e-04	33	68	3	int:TOP1MT
Interaction	SASS6 interactions	RABEP2 ERC1 CEP131 CGNL1 KIF7	2.00e-04	159	68	5	int:SASS6
Interaction	ZNF74 interactions	LRP4 TRIM27 KIF7	2.04e-04	34	68	3	int:ZNF74
Interaction	GAN interactions	SPTBN5 SYNE1 APBB2 RNF213 PLEC CROCC	2.11e-04	253	68	6	int:GAN
Interaction	KRT222 interactions	TXLNA PLEC CROCC	2.23e-04	35	68	3	int:KRT222
Interaction	RNF40 interactions	STX1A LEO1 ROCK1 AMOTL2 CIT RAD50	2.49e-04	261	68	6	int:RNF40
Interaction	RCOR1 interactions	NOL4 UBR5 ERC1 CEP131 CHD4 PLEC PALB2 RAD50	2.51e-04	494	68	8	int:RCOR1
Interaction	GARRE1 interactions	CLU SYNM UNK TRIM27 KIF7	2.52e-04	167	68	5	int:GARRE1
Interaction	BRIP1 interactions	DOCK5 NOL4 PALB2 RAD50	2.65e-04	92	68	4	int:BRIP1
Interaction	NHLRC2 interactions	TXLNA AP1G1 MYO6 ERC1 CEP131 ARHGAP35 KRT79	2.67e-04	375	68	7	int:NHLRC2
Interaction	FBF1 interactions	SPTBN5 TXLNA ERC1 CEP131 TRIM27	2.81e-04	171	68	5	int:FBF1
Interaction	KRT38 interactions	TXLNA ERC1 AMOTL2 KRT79 KIF7	2.88e-04	172	68	5	int:KRT38
Interaction	TNIK interactions	CLU SYNE1 IQSEC2 CALCOCO1 ANKRD50 CIT KIF7	2.94e-04	381	68	7	int:TNIK
Interaction	HDAC1 interactions	RABEP2 UBR5 ERC1 CEP131 CHD4 PLEC SKA3 CROCC TRIM27 CIT PALB2 RAD50	3.00e-04	1108	68	12	int:HDAC1
Interaction	ZNF621 interactions	LRP4 TRIM27	3.10e-04	8	68	2	int:ZNF621
Interaction	TXLNB interactions	TXLNA STX1A CALCOCO1 AXIN2	3.24e-04	97	68	4	int:TXLNB
Interaction	CEP63 interactions	TXLNA SYNE1 CEP131 SKA3 KIF7	3.47e-04	179	68	5	int:CEP63
Interaction	CPNE5 interactions	RABEP2 CHD4 CIT	3.84e-04	42	68	3	int:CPNE5
Interaction	RNF38 interactions	LDB1 UBR5 MYO6 PLEC	3.93e-04	102	68	4	int:RNF38
Interaction	SNRNP27 interactions	TXLNA UBR5 CHD4 ANKRD50 CIT	3.93e-04	184	68	5	int:SNRNP27
Interaction	LUC7L3 interactions	UBR5 UNK CHD4 SKA3 CIT	4.03e-04	185	68	5	int:LUC7L3
Cytoband	10q23.2	MMRN2 AGAP11	3.07e-04	17	70	2	10q23.2
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	UNK RNF213 CEP131 CARD14	1.27e-03	307	70	4	chr17q25
ToppCell	E18.5-samps-Mesenchymal-Pericyte-pericyte_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	IQSEC2 ANGEL1 SPTLC1 ARHGAP35 CROCC	4.04e-06	151	70	5	8ba15ab24fe2e71df0a2a7511ca451ad2376bd91
ToppCell	facs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLU MMRN2 CGNL1 AMOTL2 CIT	7.63e-06	172	70	5	f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCell	facs-Heart-LV-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLU MMRN2 CGNL1 AMOTL2 CIT	7.63e-06	172	70	5	6ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HAVCR2 CGNL1 SLC22A7 NR1H4 RAB11FIP3	1.27e-05	191	70	5	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HAVCR2 CGNL1 SLC22A7 NR1H4 RAB11FIP3	1.27e-05	191	70	5	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	MYO6 NEMF SCAPER ANKRD62 RAD50	1.47e-05	197	70	5	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
Drug	SR-95639A [115767-94-7]; Down 200; 10uM; PC3; HT_HG-U133A	SH3TC2 PDE1C LDB1 IQSEC2 APBB2 MYH15 POLL RAD50	1.57e-07	199	69	8	6632_DN
Drug	Ritodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; MCF7; HT_HG-U133A	RABEP2 UBA7 IQSEC2 SCAPER CROCC SLC22A7 CARD14	2.39e-06	199	69	7	2635_UP
Drug	ICI182,780; Down 200; 1uM; PC3; HT_HG-U133A	PDE1C LDB1 SLC35C2 SPTLC1 SCAPER PLEC ARHGAP35	2.47e-06	200	69	7	5931_DN
Drug	OPC 3911	PDE1C PDE1B CIT	7.45e-06	13	69	3	CID000131164
Drug	sildenafil	PDE1C PDE1B ROCK1 CIT CARD14	1.09e-05	96	69	5	CID000005212
Drug	Ritodrine hydrochloride [23239-51-2]; Down 200; 12.4uM; PC3; HT_HG-U133A	PDE1C IQSEC2 SCAPER APBB2 ARHGAP35 RAD50	2.88e-05	196	69	6	4619_DN
Drug	CI-930	PDE1C PDE1B CIT	2.93e-05	20	69	3	CID003021728
Drug	6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; PC3; HT_HG-U133A	DOCK5 IQSEC2 SCAPER MMRN2 CROCC RAB11FIP3	2.96e-05	197	69	6	4477_DN
Drug	Brompheniramine maleate [980-71-2]; Up 200; 9.2uM; PC3; HT_HG-U133A	LDB1 LAD1 SCAPER APBB2 ROCK1 NR1H4	3.05e-05	198	69	6	4013_UP
Drug	Proglumide [6620-60-6]; Up 200; 12uM; HL60; HT_HG-U133A	RABEP2 DOCK5 MYO6 IQSEC2 APBB2 ARHGAP35	3.14e-05	199	69	6	2363_UP
Drug	Arcaine sulfate [14923-17-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	STX1A CLU IQSEC2 SCAPER CROCC RAB11FIP3	3.14e-05	199	69	6	3349_DN
Drug	Bupropion hydrochloride [31677-93-7]; Up 200; 14.4uM; MCF7; HT_HG-U133A	SPTBN5 LDB1 IQSEC2 MMRN2 POLL SLC22A7	3.14e-05	199	69	6	6256_UP
Drug	benzyladenine	SYNM SPTLC1 CIT AXIN2	8.85e-05	77	69	4	CID000062389
Drug	N-methyl-N'-nitroguanidine	SYNM POLL	9.00e-05	5	69	2	CID000020237
Drug	3 alpha,6 alpha-dihydroxy-5 beta-cholanoic acid	SYNE1 PLEC NR1H4	9.20e-05	29	69	3	CID000006747
Drug	milrinone	PDE1C PDE1B SYNE1 CIT CARD14	9.29e-05	150	69	5	CID000004197
Drug	methyl iodide	UBA7 SYNE1 PLEC	1.24e-04	32	69	3	CID000006328
Drug	AC1L9XAW	SYNE1 ROCK1 POLL	1.36e-04	33	69	3	CID000477669
Drug	Rhodium	UBA7 SNPH SYNE1	1.49e-04	34	69	3	CID000023948
Drug	KHL-8430	PDE1C PDE1B	1.88e-04	7	69	2	CID000195711
Drug	5 beta-cholane	POLL NR1H4	1.88e-04	7	69	2	CID006857459
Drug	gallium-aluminum-arsenide	SYNM PLEC	2.50e-04	8	69	2	CID000089859
Drug	propranolol glycol	CLU SLC22A7	2.50e-04	8	69	2	CID000037369
Drug	ochratoxin B	CALCOCO1 CIT	2.50e-04	8	69	2	CID000020966
Drug	acronycine	UBA7 SYNE1	2.50e-04	8	69	2	CID000345512
Drug	Colchicine [64-86-8]; Up 200; 10uM; PC3; HT_HG-U133A	RABEP2 NOL4 PDE1C ARHGAP35 SLC22A7	2.87e-04	191	69	5	4614_UP
Drug	Metergoline [17692-51-2]; Up 200; 10uM; MCF7; HT_HG-U133A	STX1A CLU CALCOCO1 SCAPER PLEC	2.87e-04	191	69	5	5344_UP
Drug	Propofol [2078-54-8]; Down 200; 22.4uM; MCF7; HT_HG-U133A	RABEP2 SCAPER APBB2 ARHGAP35 RAB11FIP3	2.87e-04	191	69	5	3386_DN
Drug	Ald1.1-H_000455; Up 200; 10uM; MCF7; HT_HG-U133A	RABEP2 CALCOCO1 APBB2 MMRN2 CROCC	2.87e-04	191	69	5	7542_UP
Drug	5707885; Down 200; 50uM; PC3; HT_HG-U133A	SH3TC2 PDE1C LDB1 APBB2 CHD4	2.94e-04	192	69	5	6438_DN
Drug	2-propylpentanoic acid; Up 200; 1000uM; PC3; HT_HG-U133A	SCAPER APBB2 ARHGAP35 RAD50 RAB11FIP3	2.94e-04	192	69	5	1209_UP
Drug	Tiaprofenic acid [33005-95-7]; Up 200; 15.4uM; MCF7; HT_HG-U133A	DOCK5 IQSEC2 ARHGAP35 RAD50 RAB11FIP3	3.01e-04	193	69	5	2852_UP
Drug	STOCK1N-28457; Down 200; 20uM; MCF7; HT_HG-U133A	DOCK5 SPTLC1 MMRN2 PLEC ARHGAP35	3.01e-04	193	69	5	6869_DN
Drug	Amrinone [60719-84-8]; Down 200; 21.4uM; PC3; HT_HG-U133A	LDB1 SYNE1 SCAPER MYH15 POLL	3.01e-04	193	69	5	4488_DN
Drug	Diflorasone Diacetate [33564-31-7]; Down 200; 8uM; HL60; HT_HG-U133A	DOCK5 STX1A ANGEL1 SCAPER POLL	3.01e-04	193	69	5	2142_DN
Drug	Streptozotocin [18883-66-4]; Up 200; 15uM; PC3; HT_HG-U133A	RABEP2 STX1A IQSEC2 SCAPER APBB2	3.08e-04	194	69	5	5836_UP
Drug	Capsaicin [404-86-4]; Down 200; 13uM; PC3; HT_HG-U133A	RABEP2 SLC35C2 SPTLC1 PLEC ARHGAP35	3.08e-04	194	69	5	4612_DN
Drug	Stachydrine hydrochloride; Down 200; 22.2uM; MCF7; HT_HG-U133A	STX1A LAD1 APBB2 ARHGAP35 CROCC	3.08e-04	194	69	5	2743_DN
Drug	Acyclovir [59277-89-3]; Down 200; 17.8uM; MCF7; HT_HG-U133A	RABEP2 SYNE1 SCAPER PLEC ARHGAP35	3.08e-04	194	69	5	5278_DN
Drug	Trioxsalen [3902-71-4]; Down 200; 17.6uM; PC3; HT_HG-U133A	LDB1 SCAPER APBB2 ARHGAP35 RAD50	3.16e-04	195	69	5	5736_DN
Drug	Felodipine [72509-76-3]; Down 200; 10.4uM; MCF7; HT_HG-U133A	LDB1 LAD1 CALCOCO1 PLEC ARHGAP35	3.16e-04	195	69	5	3295_DN
Drug	Econazole nitrate [24169-02-6]; Up 200; 9uM; HL60; HT_HG-U133A	RABEP2 IQSEC2 POLL ARHGAP35 SLC22A7	3.16e-04	195	69	5	2396_UP
Drug	Flupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; MCF7; HT_HG-U133A	LDB1 SYNM CHD4 PLEC CIT	3.16e-04	195	69	5	5307_DN
Drug	Aconitine [302-27-2]; Down 200; 6.2uM; MCF7; HT_HG-U133A	STX1A LDB1 APBB2 PLEC ARHGAP35	3.16e-04	195	69	5	2776_DN
Drug	Dihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; MCF7; HT_HG-U133A	RABEP2 IQSEC2 SCAPER APBB2 PLEC	3.16e-04	195	69	5	2895_UP
Drug	Tamoxifen citrate [54965-24-1]; Down 200; 7uM; PC3; HT_HG-U133A	PDE1C SLC4A1AP CLU LAD1 CEP131	3.16e-04	195	69	5	2050_DN
Drug	Cloxacillin sodium salt [642-78-4]; Up 200; 8.8uM; PC3; HT_HG-U133A	SNPH CLU ERC1 SYNE1 APBB2	3.16e-04	195	69	5	2126_UP
Drug	IS-Gal	POLL CIT	3.21e-04	9	69	2	CID000133806
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	RABEP2 CLU SYNE1 ARHGAP35 CROCC	3.23e-04	196	69	5	5279_DN
Drug	3-nitropropionic acid; Down 200; 10uM; MCF7; HT_HG-U133A	RABEP2 SPTBN5 SYNE1 APBB2 CARD14	3.23e-04	196	69	5	6367_DN
Drug	Hydroflumethiazide [135-09-1]; Up 200; 12uM; MCF7; HT_HG-U133A	DOCK5 CLU IQSEC2 SPTLC1 APBB2	3.23e-04	196	69	5	1687_UP
Drug	Betonicine [515-25-3]; Down 200; 25.2uM; HL60; HT_HG-U133A	LDB1 SYNM SYNE1 POLL ARHGAP35	3.23e-04	196	69	5	2207_DN
Drug	Carbimazole [22232-54-8]; Down 200; 21.4uM; HL60; HT_HG-U133A	DOCK5 SYNE1 MYH15 POLL CEP131	3.23e-04	196	69	5	2437_DN
Drug	6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; HL60; HT_HG-U133A	MYO6 SYNM IQSEC2 LAD1 NR1H4	3.23e-04	196	69	5	2511_UP
Drug	Solasodine [126-17-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	DOCK5 STX1A SCAPER APBB2 POLL	3.23e-04	196	69	5	3830_DN
Drug	Ampyrone [83-07-8]; Down 200; 19.6uM; MCF7; HT_HG-U133A	RABEP2 STX1A CALCOCO1 ARHGAP35 SLC22A7	3.23e-04	196	69	5	2249_DN
Drug	Tropine [120-29-6]; Down 200; 28.4uM; HL60; HT_HG-U133A	STX1A SYNM APBB2 ARHGAP35 RAD50	3.23e-04	196	69	5	6147_DN
Drug	Bromocryptine mesylate [22260-51-1]; Down 200; 5.4uM; PC3; HT_HG-U133A	DOCK5 STX1A POLL PLEC RAB11FIP3	3.31e-04	197	69	5	4604_DN
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A	LDB1 APBB2 POLL RAD50 RAB11FIP3	3.31e-04	197	69	5	6241_UP
Drug	Folinic acid calcium salt [6035-45-6]; Up 200; 7.8uM; MCF7; HT_HG-U133A	MYO6 APBB2 POLL PLEC ARHGAP35	3.31e-04	197	69	5	3442_UP
Drug	Salbutamol [18559-94-9]; Down 200; 16.8uM; MCF7; HT_HG-U133A	LDB1 ANGEL1 SCAPER APBB2 POLL	3.31e-04	197	69	5	2306_DN
Drug	Homatropine hydrobromide (R,S) [51-56-9]; Down 200; 11.2uM; PC3; HT_HG-U133A	CALCOCO1 ANGEL1 CHD4 ARHGAP35 RAB11FIP3	3.31e-04	197	69	5	1806_DN
Drug	Apomorphine hydrochloride hemihydrate [41372-20-7]; Up 200; 6.4uM; PC3; HT_HG-U133A	SPTBN5 SCAPER LRP4 ARHGAP35 SLC22A7	3.31e-04	197	69	5	6683_UP
Drug	Furaltadone hydrochloride [3759-92-0]; Down 200; 11uM; HL60; HT_HG-U133A	STX1A SCAPER APBB2 MYH15 PLEC	3.31e-04	197	69	5	2554_DN
Drug	THIP Hydrochloride; Down 200; 22.6uM; HL60; HT_HG-U133A	APBB2 MYH15 POLL ARHGAP35 RAB11FIP3	3.31e-04	197	69	5	3132_DN
Drug	Lysergol [602-85-7]; Down 200; 15.8uM; PC3; HT_HG-U133A	SH3TC2 LDB1 SLC4A1AP CALCOCO1 POLL	3.31e-04	197	69	5	6621_DN
Drug	Rolipram [61413-54-5]; Up 200; 14.6uM; MCF7; HT_HG-U133A	SPTBN5 SCAPER APBB2 LRP4 NR1H4	3.31e-04	197	69	5	6449_UP
Drug	Tiletamine hydrochloride; Up 200; 15.4uM; PC3; HT_HG-U133A	LDB1 SYNE1 SCAPER ARHGAP35 NR1H4	3.31e-04	197	69	5	7311_UP
Drug	Diprophylline [479-18-5]; Down 200; 15.8uM; MCF7; HT_HG-U133A	STX1A CLU SCAPER POLL ARHGAP35	3.31e-04	197	69	5	5482_DN
Drug	Colistin sulfate [1264-72-8]; Down 200; 3uM; MCF7; HT_HG-U133A	IQSEC2 SCAPER APBB2 PLEC ARHGAP35	3.31e-04	197	69	5	4796_DN
Drug	Carbetapentane citrate [23142-01-0]; Up 200; 7.6uM; MCF7; HT_HG-U133A	RABEP2 UBA7 SYNE1 CROCC CARD14	3.38e-04	198	69	5	2623_UP
Drug	retinoic acid; Down 200; 1uM; PC3; HT_HG-U133A	CLU APBB2 MMRN2 MYH15 POLL	3.38e-04	198	69	5	4435_DN
Drug	Loxapine succinate [27833-64-3]; Up 200; 9uM; MCF7; HT_HG-U133A	DOCK5 STX1A LRP4 POLL CROCC	3.38e-04	198	69	5	1516_UP
Drug	Thiocolchicoside [602-41-5]; Up 200; 7uM; PC3; HT_HG-U133A	APBB2 LRP4 ARHGAP35 NR1H4 RAB11FIP3	3.38e-04	198	69	5	5095_UP
Drug	Guanabenz acetate [23256-50-0]; Up 200; 13.8uM; MCF7; HT_HG-U133A	DOCK5 STX1A UBA7 ERC1 CROCC	3.38e-04	198	69	5	1544_UP
Drug	Molindone hydrochloride [15622-65-8]; Up 200; 12.8uM; HL60; HT_HG-U133A	PDE1B IQSEC2 APBB2 PLEC ARHGAP35	3.38e-04	198	69	5	2917_UP
Drug	Lisuride (S)(-) [18016-80-3]; Up 200; 11.8uM; PC3; HG-U133A	LDB1 CLU NUDT1 ANGEL1 RAD50	3.38e-04	198	69	5	1962_UP
Drug	Pirlindole mesylate [60762-57-4]; Down 200; 12.4uM; MCF7; HT_HG-U133A	DOCK5 ERC1 SCAPER POLL CEP131	3.46e-04	199	69	5	5497_DN
Drug	Moroxidine hydrochloride [3160-91-6]; Up 200; 19.2uM; MCF7; HT_HG-U133A	DOCK5 STX1A ERC1 APBB2 POLL	3.46e-04	199	69	5	1527_UP
Drug	Tetrandrine [518-34-3]; Down 200; 6.4uM; PC3; HT_HG-U133A	SH3TC2 PDE1C MYO6 CLU CEP131	3.46e-04	199	69	5	5821_DN
Drug	Reserpine [50-55-5]; Down 200; 6.6uM; MCF7; HT_HG-U133A	RABEP2 TXLNA LDB1 CLU APBB2	3.46e-04	199	69	5	3341_DN
Drug	Aceclofenac [89796-99-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A	RABEP2 PDE1C SCAPER MMRN2 RAD50	3.46e-04	199	69	5	7029_UP
Drug	beta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; MCF7; HT_HG-U133A	STX1A LDB1 SYNE1 POLL RAB11FIP3	3.46e-04	199	69	5	2819_DN
Drug	Dinoprost trometamol [38362-01-5]; Down 200; 8.4uM; PC3; HT_HG-U133A	SH3TC2 CALCOCO1 SLC35C2 SCAPER CEP131	3.46e-04	199	69	5	6308_DN
Drug	Alprenolol hydrochloride [13707-88-5]; Up 200; 14uM; PC3; HT_HG-U133A	RABEP2 MYO6 APBB2 MMRN2 RAB11FIP3	3.46e-04	199	69	5	7141_UP
Drug	Carbetapentane citrate [23142-01-0]; Down 200; 7.6uM; PC3; HT_HG-U133A	LDB1 ERC1 POLL ARHGAP35 RAD50	3.46e-04	199	69	5	4649_DN
Drug	2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A	IQSEC2 APBB2 POLL AMOTL2 CROCC	3.46e-04	199	69	5	5219_UP
Drug	Clebopride maleate [84370-95-6]; Down 200; 8.2uM; PC3; HT_HG-U133A	SYNE1 CALCOCO1 SLC35C2 ARHGAP35 RAB11FIP3	3.46e-04	199	69	5	6311_DN
Drug	Myosmine [532-12-7]; Up 200; 27.4uM; HL60; HT_HG-U133A	STX1A LDB1 SYNE1 APBB2 RAB11FIP3	3.46e-04	199	69	5	2199_UP
Drug	Dihydrostreptomycin sulfate [5490-27-7]; Down 200; 2.8uM; MCF7; HT_HG-U133A	RABEP2 STX1A IQSEC2 CROCC CARD14	3.46e-04	199	69	5	2237_DN
Drug	Gallamine triethiodide [65-29-2]; Up 200; 4.4uM; PC3; HT_HG-U133A	SPTBN5 IQSEC2 APBB2 LRP4 CARD14	3.54e-04	200	69	5	5735_UP
Drug	2-propylpentanoic acid; Down 200; 1000uM; HL60; HG-U133A	RABEP2 DOCK5 ANGEL1 SLC35C2 CARD14	3.54e-04	200	69	5	409_DN
Disease	substance abuse, antisocial behaviour measurement	SCAPER CGNL1	1.70e-04	9	65	2	EFO_0007052, MONDO_0002491
Disease	lung adenocarcinoma (is_implicated_in)	UBR5 CHD4 AXIN2	1.75e-04	49	65	3	DOID:3910 (is_implicated_in)
Disease	Bardet-Biedl syndrome (implicated_via_orthology)	SCAPER CEP131	2.59e-04	11	65	2	DOID:1935 (implicated_via_orthology)
Disease	unipolar depression, bipolar disorder	NOL4 SYNE1 MMRN2 MYH15	3.96e-04	156	65	4	EFO_0003761, MONDO_0004985
Disease	Hereditary Breast and Ovarian Cancer Syndrome	PALB2 RAD50	4.27e-04	14	65	2	C0677776
Disease	Benign neoplasm of stomach	UBR5 AXIN2	6.36e-04	17	65	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	UBR5 AXIN2	6.36e-04	17	65	2	C0496905
Disease	Carcinoma in situ of stomach	UBR5 AXIN2	6.36e-04	17	65	2	C0154060
Disease	Stomach Carcinoma	UBR5 AXIN2	9.77e-04	21	65	2	C0699791
Disease	Myasthenic Syndromes, Congenital	LRP4 PLEC	1.28e-03	24	65	2	C0751882
Disease	colon adenocarcinoma (is_implicated_in)	UBR5 CHD4	1.50e-03	26	65	2	DOID:234 (is_implicated_in)
Disease	white matter microstructure measurement	DOCK5 SCAPER UNK PLEC TRIM27	1.70e-03	390	65	5	EFO_0005674
Disease	Breast Cancer, Familial	PALB2 RAD50	2.00e-03	30	65	2	C0346153
Disease	Drug habituation	PDE1C MYO6 SYNE1	2.11e-03	115	65	3	C0013170
Disease	Substance-Related Disorders	PDE1C MYO6 SYNE1	2.11e-03	115	65	3	C0236969
Disease	Drug abuse	PDE1C MYO6 SYNE1	2.11e-03	115	65	3	C0013146
Disease	Drug Use Disorders	PDE1C MYO6 SYNE1	2.11e-03	115	65	3	C0013222
Disease	Drug Dependence	PDE1C MYO6 SYNE1	2.11e-03	115	65	3	C1510472
Disease	Substance Dependence	PDE1C MYO6 SYNE1	2.11e-03	115	65	3	C0038580
Disease	Substance Use Disorders	PDE1C MYO6 SYNE1	2.11e-03	115	65	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	PDE1C MYO6 SYNE1	2.11e-03	115	65	3	C0029231
Disease	Prescription Drug Abuse	PDE1C MYO6 SYNE1	2.11e-03	115	65	3	C4316881
Disease	Substance abuse problem	PDE1C MYO6 SYNE1	2.17e-03	116	65	3	C0740858

Protein segments in the cluster

Peptide	Gene	Start	Entry
DRDQSRLDTAGLAEL	AMER3	336	Q8N944
RDNERLQRELESSAE	AMOTL2	326	Q9Y2J4
EDGARRELQEESGLT	NUDT1	46	P36639
ERDADRSLTILDEQL	AGAP11	16	Q8TF27
ADLETSARELEQNRG	APBB2	166	Q92870
SSERRINLEDEAQSL	ANKRD62	881	A6NC57
DEEREGSELTLNSRE	AXIN2	401	Q9Y2T1
ALEREDSIRTLLDNG	ANKRD50	521	Q9ULJ7
RELEKLQNREDSSEG	CIT	671	O14578
RLLDSLRQEGFLTDD	POLL	446	Q9UGP5
LEEARRREDNLNDSS	ERC1	811	Q8IUD2
QLEGSSDRILELDQE	RAD50	466	Q92878
LESVSRERDELQEGL	RABEP2	306	Q9H5N1
TRLQQLDEENSELRS	RAB11FIP3	546	O75154
DQTVNEDSEGRDLRQ	NR1H4	231	Q96RI1
RLLRILGRNDDDSSE	AP1G1	251	O43747
EERPQLSDDERQQLS	LEO1	191	Q8WVC0
LSSLARQRTLEDEEE	LAD1	11	O00515
GDEDERLITRLENTQ	LDB1	351	Q86U70
QEDITLQSGRDELNE	NEMF	726	O60524
EETQVSLDERRQLDG	MMRN2	516	Q9H8L6
LDQLTQENRDLREES	IQSEC2	51	Q5JU85
SERGRLDSELRNVQD	KRT79	211	Q5XKE5
RQILDTEDELQELRS	PDE1B	76	Q01064
RRLLDTEDELSDIQS	PDE1C	81	Q14123
TASRDIQLREDERGN	KIF7	161	Q2M1P5
TEDLTENGQDLRRTL	MICB	86	Q29980
TLDGRNENLQESEIL	PALB2	361	Q86YC2
ERSGELEQQRLRDTE	CROCC	196	Q5TZA2
LETEDGEGLQQTLRD	CROCC	441	Q5TZA2
LSDSESERRALEEQL	CROCC	556	Q5TZA2
ILEQSLDEARGSRQE	CARD14	286	Q9BXL6
EDLSLREENSENRIS	DOCK5	1716	Q9H7D0
STLQQRLEESEGELR	CGNL1	666	Q0VF96
ELEEERNNSDLLSER	CGNL1	1076	Q0VF96
RDLLSDLQDISDSER	CDK11A	261	Q9UQ88
DILSLRDRGLSEQEA	KNDC1	41	Q76NI1
RLLDRNQDETEDTEL	CHD4	1256	Q14839
EEGERSRDLQEERLS	DHX40	16	Q8IX18
NTTLGEERQSRGELE	SLC22A7	91	Q9Y694
RENTSIQGRELSDEE	SCAPER	821	Q9BY12
RLNETELTDLEGQQE	SLC39A10	576	Q9ULF5
EITEERDILSRQQGD	CALCOCO1	211	Q9P1Z2
REEQRQRSGEGTLLD	CEP131	301	Q9UPN4
ELLQDIGDTLSRAER	TRIM27	246	P14373
SELDGDIQEALRTRQ	SYNE1	4971	Q8NF91
AEEARSLRQQLDELS	SYNM	61	O15061
AERRNSLLQSELEDL	MYH15	1686	Q9Y2K3
ELEDLRSLQEQTERG	MYH15	1696	Q9Y2K3
NELRDSRLANDLRDS	HAVCR2	181	Q8TDQ0
DEELQDTIRSRLDNI	SH3TC2	1246	Q8TF17
TQDRLQDRDTEIDDL	SNPH	96	O15079
LDNDLSREQLTEGEE	ARHGAP35	896	Q9NRY4
NESVDRGAEDLSLNR	NOL4	366	O94818
LQLEESTGSREQDVR	SPTLC1	396	O15269
QELAATRDRELEGTL	SPTBN5	1716	Q9NRC6
SRQLSDLRAAENLDE	ANGEL1	111	Q9UNK9
EATESRLRGLDQQLD	CNGA4	491	Q8IV77
GDRIDSLLENDRQQT	CLU	156	P10909
ETARLQRALDGEESD	SKA3	21	Q8IX90
DDSRLLLDEITRAQD	RNF213	2716	Q63HN8
QDLERSRAEASQELL	UBA7	81	P41226
EQEEGLNRSSADLRI	STX1A	101	Q16623
LLLRSSQREEGDNEE	SLC35C2	341	Q9NQQ7
LELELGRIRSNAEDT	PLEC	2081	Q15149
LSGELENTNIEREAE	SUCO	681	Q9UBS9
ELDEEGNQRRNLEST	ROCK1	466	Q13464
ARLRDSGLSQEEEED	ZRSR2P1	41	Q15695
ELARLRQELDEANST	UNK	646	Q9C0B0
RTRELLELGIDNEDS	UBR5	1976	O95071
GALRDVSEELSRQLE	TXLNA	66	P40222
ADRLTGLDRETLQEN	LRP4	971	O75096
DEAQADLALRRSLDS	MYO6	1026	Q9UM54
LNDAERELSEISERL	SLC4A1AP	506	Q9BWU0