Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine N-sulfotransferase activity	NDST2 NDST4 NDST3	4.71e-07	4	99	3	GO:0015016
GeneOntologyMolecularFunction	N-acetylglucosamine deacetylase activity	NDST2 NDST4 NDST3	4.71e-07	4	99	3	GO:0050119
GeneOntologyMolecularFunction	heparan sulfate sulfotransferase activity	NDST2 NDST4 NDST3	5.15e-05	15	99	3	GO:0034483
GeneOntologyMolecularFunction	heparan sulfate N-deacetylase activity	NDST2 NDST3	7.28e-05	3	99	2	GO:0102140
GeneOntologyMolecularFunction	ubiquitin-like protein-specific endopeptidase activity	SENP6 SENP7	2.41e-04	5	99	2	GO:0070137
GeneOntologyMolecularFunction	SUMO-specific endopeptidase activity	SENP6 SENP7	2.41e-04	5	99	2	GO:0070139
GeneOntologyMolecularFunction	cargo receptor activity	TMED7 ITGAM TMED3 LRP1	8.46e-04	85	99	4	GO:0038024
GeneOntologyMolecularFunction	deacetylase activity	NDST2 NDST4 NDST3	1.02e-03	40	99	3	GO:0019213
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	NDST2 NDST4 NDST3	5.55e-06	8	97	3	GO:0015014
GeneOntologyBiologicalProcess	heparin biosynthetic process	NDST2 NDST4 NDST3	1.62e-05	11	97	3	GO:0030210
GeneOntologyBiologicalProcess	heparin metabolic process	NDST2 NDST4 NDST3	6.54e-05	17	97	3	GO:0030202
Domain	Heparan_SO4_deacetylase	NDST2 NDST4 NDST3	5.93e-07	4	100	3	IPR021930
Domain	HSNSD	NDST2 NDST4 NDST3	5.93e-07	4	100	3	PF12062
Domain	DUF1220	NBPF1 NBPF9 NBPF14	2.38e-05	11	100	3	PF06758
Domain	NBPF_dom	NBPF1 NBPF9 NBPF14	2.38e-05	11	100	3	IPR010630
Domain	NBPF	NBPF1 NBPF9 NBPF14	2.38e-05	11	100	3	PS51316
Domain	TMED7	TMED7 TMED3	8.48e-05	3	100	2	IPR015718
Domain	Peptidase_C48_C	SENP6 SENP7	5.86e-04	7	100	2	IPR003653
Domain	Peptidase_C48	SENP6 SENP7	5.86e-04	7	100	2	PF02902
Domain	GAF	PDE6C PDE6B	5.86e-04	7	100	2	PF01590
Domain	ULP_PROTEASE	SENP6 SENP7	5.86e-04	7	100	2	PS50600
Domain	GAF	PDE6C PDE6B	7.78e-04	8	100	2	IPR003018
Domain	GAF	PDE6C PDE6B	7.78e-04	8	100	2	SM00065
Domain	Sulfotransfer_1	NDST2 NDST4 NDST3	9.35e-04	36	100	3	PF00685
Domain	Sulfotransferase_dom	NDST2 NDST4 NDST3	9.35e-04	36	100	3	IPR000863
Domain	-	PDE6C PDE6B	9.97e-04	9	100	2	3.30.450.40
Domain	GAF_dom-like	PDE6C PDE6B	9.97e-04	9	100	2	IPR029016
Domain	DUF1220	NBPF1 NBPF9	9.97e-04	9	100	2	SM01148
Pathway	KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS	NDST2 NDST4 NDST3	2.22e-05	11	74	3	M47921
Pubmed	Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.	NDST2 NDST4 NDST3	1.01e-07	4	103	3	22049073
Pubmed	Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.	NDST2 NDST4 NDST3	1.01e-07	4	103	3	12070138
Pubmed	Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.	NDST2 NDST4 NDST3	2.51e-07	5	103	3	11087757
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF20 NBPF1 NBPF9 NBPF14	4.18e-07	21	103	4	16079250
Pubmed	FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.	NDST2 NDST4 NDST3	1.40e-06	8	103	3	24067353
Pubmed	A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.	MYO7A CDH23 PGAP1	2.98e-06	10	103	3	17329413
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF1 NBPF9 NBPF14	2.98e-06	10	103	3	22973535
Pubmed	Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.	NDST2 NDST4 NDST3	4.09e-06	11	103	3	15944372
Pubmed	Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.	NDST2 NDST4 NDST3	5.44e-06	12	103	3	12460940
Pubmed	Mutation analysis of the MYO7A and CDH23 genes in Japanese patients with Usher syndrome type 1.	MYO7A CDH23	8.69e-06	2	103	2	20844544
Pubmed	Cluster III of low-density lipoprotein receptor-related protein 1 binds activated blood coagulation factor VIII.	F8 LRP1	8.69e-06	2	103	2	25486042
Pubmed	Cone Phosphodiesterase-6γ' Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits.	PDE6C PDE6B	8.69e-06	2	103	2	30038560
Pubmed	Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.	PDE6C PDE6B	8.69e-06	2	103	2	26085644
Pubmed	Genetic heterogeneity and consanguinity lead to a "double hit": homozygous mutations of MYO7A and PDE6B in a patient with retinitis pigmentosa.	PDE6B MYO7A	8.69e-06	2	103	2	23882135
Pubmed	Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes.	NDST2 NDST3	8.69e-06	2	103	2	12417402
Pubmed	Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.	F8 LRP1	8.69e-06	2	103	2	27794518
Pubmed	Unr defines a novel class of nucleoplasmic reticulum involved in mRNA translation.	CSDE1 NR1H2	8.69e-06	2	103	2	28386023
Pubmed	A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels.	F8 LRP1	8.69e-06	2	103	2	28431990
Pubmed	Proteolytic cleavage of factor VIII heavy chain is required to expose the binding-site for low-density lipoprotein receptor-related protein within the A2 domain.	F8 LRP1	8.69e-06	2	103	2	16839343
Pubmed	Calcium dynamics change in degenerating cone photoreceptors.	PDE6C PDE6B	8.69e-06	2	103	2	27402880
Pubmed	Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.	F8 LRP1	8.69e-06	2	103	2	25903134
Pubmed	Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation.	MYO7A CDH23	8.69e-06	2	103	2	14648237
Pubmed	[Usher type I syndrome in children: genotype/phenotype correlation and cochlear implant benefits].	MYO7A CDH23	8.69e-06	2	103	2	18323324
Pubmed	Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration.	MYO7A CDH23	8.69e-06	2	103	2	14609561
Pubmed	NTM and NR3C2 polymorphisms influencing intelligence: family-based association studies.	NTM NR3C2	8.69e-06	2	103	2	21036197
Pubmed	Systematic spatiotemporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration.	PDE6C PDE6B	8.69e-06	2	103	2	31710697
Pubmed	Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice.	MYO7A CDH23	8.69e-06	2	103	2	12121736
Pubmed	Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7.	SENP6 SENP7	8.69e-06	2	103	2	18799455
Pubmed	Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation.	F8 LRP1	8.69e-06	2	103	2	18166789
Pubmed	The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.	NACC1 TFDP3 MTA3 SMC3	1.63e-05	51	103	4	22770845
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SH3TC2 DYNC2H1 PLEKHA6 FARP2 RAB3GAP1 SSH1 SBF2 MACF1 MAST3	1.66e-05	493	103	9	15368895
Pubmed	Neuronal Localization of SENP Proteins with Super Resolution Microscopy.	SENP6 SENP7	2.60e-05	3	103	2	33113832
Pubmed	The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared within coagulation factor VIII.	F8 LRP1	2.60e-05	3	103	2	18277139
Pubmed	Genetic analysis through OtoSeq of Pakistani families segregating prelingual hearing loss.	MYO7A CDH23	2.60e-05	3	103	2	23770805
Pubmed	Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice.	MYO7A CDH23	2.60e-05	3	103	2	17050716
Pubmed	Survey of the frequency of USH1 gene mutations in a cohort of Usher patients shows the importance of cadherin 23 and protocadherin 15 genes and establishes a detection rate of above 90%.	MYO7A CDH23	2.60e-05	3	103	2	16679490
Pubmed	Regulation of FcgammaR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup.	INPP5D ITGAM	2.60e-05	3	103	2	17682126
Pubmed	Macrophage LRP1 contributes to the clearance of von Willebrand factor.	F8 LRP1	2.60e-05	3	103	2	22234691
Pubmed	Differential distribution of harmonin isoforms and their possible role in Usher-1 protein complexes in mammalian photoreceptor cells.	MYO7A CDH23	2.60e-05	3	103	2	14578428
Pubmed	Contribution of low density lipoprotein receptor-related protein genotypes to coagulation factor VIII levels in thrombotic women.	F8 LRP1	2.60e-05	3	103	2	16956829
Pubmed	Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids.	MYO7A CDH23	2.60e-05	3	103	2	20639393
Pubmed	A high-resolution genetic map around waltzer on mouse chromosome 10 and identification of a new allele of waltzer.	CDH23 ROS1	2.60e-05	3	103	2	9021139
Pubmed	Molecular basis for the interaction of low density lipoprotein receptor-related protein 1 (LRP1) with integrin alphaMbeta2: identification of binding sites within alphaMbeta2 for LRP1.	ITGAM LRP1	2.60e-05	3	103	2	21676865
Pubmed	Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.	NDST2 NDST3	2.60e-05	3	103	2	9915799
Pubmed	C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosa.	PDE6B ITGAM	2.60e-05	3	103	2	31209071
Pubmed	Low density lipoprotein receptor-related protein and factor IXa share structural requirements for binding to the A3 domain of coagulation factor VIII.	F8 LRP1	2.60e-05	3	103	2	12522143
Pubmed	The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse.	MYO7A CDH23	2.60e-05	3	103	2	13336002
Pubmed	Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.	NDST2 NDST4 NDST3	2.77e-05	20	103	3	17107998
Pubmed	NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.	NDST2 NDST4 NDST3	3.73e-05	22	103	3	19299468
Pubmed	Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells.	MYO7A CDH23	5.19e-05	4	103	2	16481439
Pubmed	Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20.	INPP5D IRAK4	5.19e-05	4	103	2	21934070
Pubmed	Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice.	PDE6C PDE6B	5.19e-05	4	103	2	31825309
Pubmed	The SUMO protease SENP6 is essential for inner kinetochore assembly.	CENPI SENP6	5.19e-05	4	103	2	20212317
Pubmed	Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.	PDE6C PDE6B	5.19e-05	4	103	2	23033484
Pubmed	Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses.	TMC2 CDH23	5.19e-05	4	103	2	34734805
Pubmed	Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation.	NDST2 NDST3	5.19e-05	4	103	2	29688404
Pubmed	Rod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunit.	PDE6C PDE6B	5.19e-05	4	103	2	21799013
Pubmed	Factor XIII activity mediates red blood cell retention in venous thrombi.	ITGAM F8	5.19e-05	4	103	2	24983320
Pubmed	Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides.	ITGAM LRP1	5.19e-05	4	103	2	20199584
Pubmed	Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses.	NDST2 NDST3	5.19e-05	4	103	2	16056228
Pubmed	Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.	RRM2B TXN	5.19e-05	4	103	2	11517226
Pubmed	NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.	NACC1 MTA3 SMC3	7.01e-05	27	103	3	23395962
Pubmed	The DDX6-4E-T interaction mediates translational repression and P-body assembly.	CSDE1 NR1H2	8.64e-05	5	103	2	27342281
Pubmed	Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin.	MYO7A CDH23	8.64e-05	5	103	2	12588794
Pubmed	Interactions in the network of Usher syndrome type 1 proteins.	MYO7A CDH23	8.64e-05	5	103	2	15590703
Pubmed	Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.	MYO7A CDH23	8.64e-05	5	103	2	20332152
Pubmed	Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population.	MYO7A CDH23	8.64e-05	5	103	2	15660226
Pubmed	Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells.	MYO7A CDH23	8.64e-05	5	103	2	16219682
Pubmed	Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes.	MYO7A CDH23	8.64e-05	5	103	2	22381527
Pubmed	Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7.	SENP6 SENP7	8.64e-05	5	103	2	21878624
Pubmed	Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle.	MYO7A CDH23	8.64e-05	5	103	2	12485990
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	F8 LRP1	8.64e-05	5	103	2	18685438
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	USP34 TMED7 COPS2 INF2 KCNJ3 ARHGEF1 PGAP1 SBF2 VPS35L IRAK4 MACF1 XPOT	8.93e-05	1084	103	12	11544199
Pubmed	Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration.	ITGAM LRP1	1.29e-04	6	103	2	16601674
Pubmed	Impact of the Usher syndrome on olfaction.	MYO7A CDH23	1.29e-04	6	103	2	26620972
Pubmed	Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway.	TMED7 TMED3	1.29e-04	6	103	2	12237308
Pubmed	Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit.	PDE6C PDE6B	1.29e-04	6	103	2	19798052
Pubmed	DEL-1 promotes macrophage efferocytosis and clearance of inflammation.	ITGAM NR1H2	1.29e-04	6	103	2	30455459
Pubmed	A mouse model for studying cone photoreceptor pathologies.	PDE6C PDE6B	1.29e-04	6	103	2	25034607
Pubmed	An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.	ITGAM LRP1	1.29e-04	6	103	2	24509082
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	ADGRG5 TMC2 CDH23 LINGO2 TMED3 NDST3 EYS NTM PGAP1 GBGT1 BAIAP2L2	1.65e-04	985	103	11	12975309
Pubmed	TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.	RPGRIP1L MKS1	1.81e-04	7	103	2	26595381
Pubmed	Altered heparan sulfate structure in mice with deleted NDST3 gene function.	NDST2 NDST3	1.81e-04	7	103	2	18385133
Pubmed	Inflammatory macrophages exploit unconventional pro-phagocytic integrins for phagocytosis and anti-tumor immunity.	ITGAM LRP1	1.81e-04	7	103	2	34910922
Pubmed	Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.	MYO7A CDH23	1.81e-04	7	103	2	15572405
Pubmed	Usher Syndrome Type I	MYO7A CDH23	1.81e-04	7	103	2	20301442
Pubmed	Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.	PDE6C PDE6B	1.81e-04	7	103	2	25392995
Pubmed	Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.	MYO7A CDH23	1.81e-04	7	103	2	21436032
Pubmed	[Studies on the genetics and pathology of the development of 8 labyrinth mutants (deaf-waltzer-shaker mutants) in the mouse (Mus musculus)].	MYO7A CDH23	1.81e-04	7	103	2	13853422
Pubmed	Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.	TMC2 MYO7A	1.81e-04	7	103	2	30108230
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	USP34 FARP2 SENP6 MACF1	2.38e-04	101	103	4	9872452
Pubmed	Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.	TMC2 BAIAP2L2	2.40e-04	8	103	2	35044843
Pubmed	Detection and identification of transcription factors as interaction partners of alien in vivo.	COPS2 MED23	2.40e-04	8	103	2	17438371
Pubmed	Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.	MYO7A CDH23	2.40e-04	8	103	2	19683999
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	MYO7A CDH23	2.40e-04	8	103	2	21165971
Pubmed	UMD-USHbases: a comprehensive set of databases to record and analyse pathogenic mutations and unclassified variants in seven Usher syndrome causing genes.	MYO7A CDH23	2.40e-04	8	103	2	18484607
Pubmed	Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.	MYO7A CDH23	2.40e-04	8	103	2	16545802
Pubmed	LMO7 deficiency reveals the significance of the cuticular plate for hearing function.	TMC2 MYO7A	2.40e-04	8	103	2	30850599
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MTA3 ZBTB21 MACF1 MED23	2.56e-04	103	103	4	10574462
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	MSH3 COPS2 RAB3GAP1 CYFIP1 MTA3 SMC3 MED23 XPOT	2.68e-04	560	103	8	35241646
Interaction	NDST3 interactions	NDST2 NDST4 NDST3	1.00e-05	9	101	3	int:NDST3
GeneFamily	Neuroblastoma breakpoint family	NBPF26 NBPF20 NBPF1 NBPF9 NBPF14	2.77e-08	23	72	5	662
GeneFamily	SUMO specific peptidases	SENP6 SENP7	3.24e-04	7	72	2	984
GeneFamily	Sulfotransferases, membrane bound	NDST2 NDST4 NDST3	4.27e-04	37	72	3	763
GeneFamily	Transmembrane p24 trafficking proteins	TMED7 TMED3	6.89e-04	10	72	2	1064
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ3 KCNJ13	1.81e-03	16	72	2	276
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY10 TMC2 MYT1 NDST4 FREM2 CNTNAP5 ABCA5 ROS1	4.22e-09	162	103	8	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY10 TMC2 MYT1 NDST4 FREM2 CNTNAP5 ROS1	4.78e-08	145	103	7	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-5\|TCGA-Skin / Sample_Type by Project: Shred V9	MYT1 PCNX2 NDST3 FREM2 MRC2 NTM	3.67e-06	178	103	6	ad5cd505ca1cef8ac29b2af7e2c3e01ebc140c14
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DYNC2H1 PLEKHA6 MRC2 NTM LRP1 MACF1	6.56e-06	197	103	6	fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	MYO7A PLEKHA6 MRC2 NTM LRP1 MACF1	7.15e-06	200	103	6	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	MYO7A PLEKHA6 MRC2 NTM LRP1 MACF1	7.15e-06	200	103	6	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
Computational	Neighborhood of RAB10	NACC1 TMED7 YTHDF1 HSD17B12 MACF1 MED23 XPOT	5.20e-05	176	60	7	GCM_RAB10
Drug	Leflunomide [75706-12-6]; Down 200; 14.8uM; PC3; HT_HG-U133A	USP34 MSH3 F8 MKS1 PCNX2 RAB3GAP1 INF2 IRAK4 MAST3	2.59e-07	197	102	9	5884_DN
Drug	ferrous ammonium sulfate	ACO1 RRM2B FARP2 NTM	7.16e-06	28	102	4	CID000024863
Disease	Disorder of eye	PDE6C RPGRIP1L PDE6B MYO7A CDH23 MKS1 FREM2 EYS KCNJ13	3.25e-08	212	96	9	C0015397
Disease	Ciliopathies	RPGRIP1L MYO7A DYNC2H1 CDH23 MKS1 KCNJ13	1.65e-06	110	96	6	C4277690
Disease	autism spectrum disorder (implicated_via_orthology)	NDST2 NDST4 NDST3 CSDE1 CNTNAP5 NR3C2	1.07e-05	152	96	6	DOID:0060041 (implicated_via_orthology)
Disease	pulse pressure measurement, migraine with aura	STXBP2 LRP1	6.26e-05	4	96	2	EFO_0005763, MONDO_0005475
Disease	migraine disorder, pulse pressure measurement	DYNC2H1 STXBP2 LRP1	8.22e-05	26	96	3	EFO_0005763, MONDO_0005277
Disease	azoospermia (implicated_via_orthology)	NDST2 NDST4 NDST3	9.22e-05	27	96	3	DOID:14227 (implicated_via_orthology)
Disease	Usher syndrome, type 1A	MYO7A CDH23	1.04e-04	5	96	2	C2931205
Disease	YKL40 measurement, cerebrospinal fluid biomarker measurement	EYS CNTNAP5	1.04e-04	5	96	2	EFO_0004869, EFO_0006794
Disease	USHER SYNDROME, TYPE IB (disorder)	MYO7A CDH23	1.04e-04	5	96	2	C1848638
Disease	USHER SYNDROME, TYPE IA, FORMERLY	MYO7A CDH23	1.04e-04	5	96	2	C1848639
Disease	USHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY	MYO7A CDH23	1.04e-04	5	96	2	C1848640
Disease	migraine without aura	STXBP2 LRP1	1.04e-04	5	96	2	MONDO_0100431
Disease	Usher syndrome type 1	MYO7A CDH23	1.04e-04	5	96	2	cv:C1568247
Disease	Usher Syndrome, Type I	MYO7A CDH23	1.56e-04	6	96	2	C1568247
Disease	retinal degeneration (implicated_via_orthology)	PDE6C PDE6B EYS	1.70e-04	33	96	3	DOID:8466 (implicated_via_orthology)
Disease	Hereditary retinal dystrophy	MYO7A CDH23	2.18e-04	7	96	2	C0154860
Disease	Usher syndrome	MYO7A CDH23	2.18e-04	7	96	2	cv:C0271097
Disease	Meckel syndrome (implicated_via_orthology)	RPGRIP1L MKS1	2.90e-04	8	96	2	DOID:0050778 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease	SH3TC2 INF2 SBF2	3.49e-04	42	96	3	cv:C0007959
Disease	pulse pressure measurement, migraine without aura, susceptibility to, 4	STXBP2 LRP1	3.72e-04	9	96	2	EFO_0005763, MONDO_0011847
Disease	Meckel-Gruber syndrome	RPGRIP1L MKS1	4.63e-04	10	96	2	cv:C0265215
Disease	Polydactyly	RPGRIP1L DYNC2H1 MKS1 FREM2	5.89e-04	117	96	4	C0152427
Disease	cardiac troponin T measurement	INPP5D CDH23 LINGO2 MRC2 NTM	7.60e-04	219	96	5	EFO_0005043
Disease	Charcot-Marie-Tooth disease type 4	SH3TC2 SBF2	7.98e-04	13	96	2	cv:C4082197
Disease	intermediate coronary syndrome (is_marker_for)	ITGAM TXN	7.98e-04	13	96	2	DOID:8805 (is_marker_for)
Disease	response to antipsychotic drug	DYNC2H1 EYS CNTNAP5	9.98e-04	60	96	3	GO_0097332
Disease	Meckel-Gruber syndrome	RPGRIP1L MKS1	1.07e-03	15	96	2	C0265215
Disease	migraine disorder	LINGO2 STXBP2 DCLRE1C MRC2 LRP1 MACF1	1.12e-03	357	96	6	MONDO_0005277
Disease	Headache	STXBP2 LRP1 MACF1	1.20e-03	64	96	3	HP_0002315
Disease	Rolandic epilepsy	PTCHD3 NR3C2	1.22e-03	16	96	2	Orphanet_1945
Disease	migraine without aura, susceptibility to, 4	STXBP2 LRP1	1.22e-03	16	96	2	MONDO_0011847
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	LINGO2 NTM LRP1 HSD17B12 MACF1 SENP7	1.23e-03	364	96	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	hearing loss	CDH23 ITGAM BAIAP2L2	1.37e-03	67	96	3	EFO_0004238
Disease	Muscle hypotonia	RRM2B MSL3	1.38e-03	17	96	2	C0026827
Disease	cervical artery dissection	STXBP2 LRP1	1.38e-03	17	96	2	EFO_1000059
Disease	Myeloid Leukemia	ATG2B SMC3	1.55e-03	18	96	2	C0023470
Disease	Leukemia, Monocytic, Chronic	ATG2B SMC3	1.55e-03	18	96	2	C0023466
Disease	Meckel syndrome type 1	RPGRIP1L MKS1	1.55e-03	18	96	2	C3714506
Disease	bipolar disorder, body mass index	RPGRIP1L CDH23 LINGO2	1.69e-03	72	96	3	EFO_0004340, MONDO_0004985
Disease	migraine disorder, endometriosis	EYS STXBP2 SBF2	1.76e-03	73	96	3	EFO_0001065, MONDO_0005277
Disease	intellectual disability (implicated_via_orthology)	NDST2 NDST4 NDST3	1.90e-03	75	96	3	DOID:1059 (implicated_via_orthology)
Disease	Retinal Degeneration	RPGRIP1L PDE6B	2.11e-03	21	96	2	C0035304
Disease	platelet reactivity measurement, response to clopidogrel	LINGO2 NR3C2	2.53e-03	23	96	2	EFO_0004985, GO_1903493

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSEKDYVFAAVFNST	ABCA5	961	Q8WWZ7
HAFAIEEYSFSQATL	ABCA5	1591	Q8WWZ7
DHKTFIYDNTEFTLA	ACO1	411	P21399
VFHAKAVEVYSSAFQ	CIBAR2	191	Q6ZTR7
FLDFYHSFLEKTAVL	ARHGEF1	96	Q92888
FEKAHTDFFEAFKNY	COPS2	251	P61201
SQLIFKEDFLHDSYF	ALPK2	1896	Q86TB3
ANHDKEIFFHYSEFS	CSDE1	536	O75534
SVTQEHIFSKAFFYF	ADCY10	1366	Q96PN6
YVATTFKYVFDFHAE	ACSS2	336	Q9NR19
FTNHFFDTYLLISED	CDH23	31	Q9H251
DSFSAFKSAVHYDEE	ATG2B	1001	Q96BY7
TDFLFEKSANYFHSE	NDST3	661	O95803
FESFIIEIFYFHKSI	RAD51AP2	506	Q09MP3
SFADFKFSVTHHYLV	RAB3GAP1	66	Q15042
VFFDTFFNIEKYLDH	PPP2R3B	466	Q9Y5P8
SERDAIYKEFSFHNF	PCBD2	56	Q9H0N5
ESYVKHFAISAAFSA	MSL3P1	136	P0C860
DIEKFHRESFFYTHL	CYFIP1	591	Q7L576
SHAFQAVTEFYAKDT	MSH3	466	P20585
YTVVTEFFLTAFTEH	OR9Q2	6	Q8NGE9
SDYFRALFKSHTQES	KLHL34	51	Q8N239
FDISAYFSSAADFIH	DUSP13	101	Q6B8I1
FLTHFDTIFEVFYNS	LINS1	216	Q8NG48
FCFYTFRESHALKVE	NR3C2	941	P08235
SDISFHYEFHLKFQL	EYS	2436	Q5T1H1
VYKFFDFADHDTAII	RPGRIP1L	816	Q68CZ1
FLSKLIFFNVSEHDY	NTM	276	Q9P121
AFHYVSNRFKTFLLD	SBF2	1501	Q86WG5
FHAETGFIYFADTTS	LRP1	566	Q07954
STFTSKFGHVFYFVQ	ARRDC5	121	A6NEK1
ATYHFIFAQKNFFTD	KIAA1109	486	Q2LD37
FSFTVTDGTHTDFYV	FREM2	1616	Q5SZK8
FHALSEAAEVYFSAI	BAIAP2L2	41	Q6UXY1
TVIFFHFDYKDISES	PCNX2	1251	A6NKB5
HFDYKDISESFLLDF	PCNX2	1256	A6NKB5
DFVCTFVYKEFSRFH	PDE6B	776	P35913
DFVCTFVYKEFSRFH	PDE6C	781	P51160
AHVRTFADFLVYEFS	MED23	821	Q9ULK4
ESYVKHFAINAAFSA	MSL3	211	Q8N5Y2
KYITSFTAAFSFSLE	KCNJ13	101	O60928
RFQEAEYKFFEHHST	MRC2	831	Q9UBG0
RSFKDFHSTALSFYF	LINGO2	391	Q7L985
DFLSVFFSGYTFKHK	F8	666	P00451
DFLFEKSANYFHSEE	NDST4	661	Q9H3R1
FATDIFSAYDVLFHQ	MROH1	216	Q8NDA8
FYSFEEQHISFALDV	NBPF1	1176	Q3BBV0
FTEERAKLASADHFY	INF2	691	Q27J81
HVKENTAYFQFFSDA	MACF1	781	Q9UPN3
LAKFSFYFHEALSRQ	KICS2	266	Q96MD2
RAKFTVDDYSHYFFT	DYNC2H1	2481	Q8NCM8
GIAEYFFKSASFAHF	BPIFC	281	Q8NFQ6
FFYEFSDSSLSKLVA	BNIP5	566	P0C671
FSFHSSYSEIKDFLS	DCLRE1C	316	Q96SD1
YTHFIQSFLESAEEF	GBGT1	121	Q8N5D6
KTFVDFFSQCLHEEY	HSD17B12	206	Q53GQ0
SHRFSKVYSSSEFLA	MAST3	701	O60307
SDTRFHSFSFYELKN	IRAK4	161	Q9NWZ3
AAFSASKAYLDHFSR	HSDL1	216	Q3SXM5
DHLAQLFFTSTIYFK	CENPI	476	Q92674
SHVYFFRAESKYTFE	FARP2	1001	O94887
VFKASVDIAFLYVFH	GJB5	136	O95377
TFHAEFSADISFFFK	CNTNAP5	806	Q8WYK1
FDFSVHISYAFVSSS	PTCHD3	866	Q3KNS1
QAFFLHTTYFTKFAR	MTA3	466	Q9BTC8
LLSVTSYSSFAFHKF	HHLA1	101	C9JL84
VSYISKEHFGTFFEC	UTP20	281	O75691
ELVERSHIFSSFFYK	SENP7	796	Q9BQF6
FFYAIQFVLSDEFSH	SMC3	41	Q9UQE7
SKEHYHFYEISSFSE	PLCD4	511	Q9BRC7
SVFYSFEEQHISFAL	NBPF9	1071	P0DPF3
SVFYSFEEEHISFAL	NBPF14	881	Q5TI25
RSVFYSFEEQHISFA	NBPF20	5166	P0DPF2
RSVFYSFEEEHISFA	NBPF26	861	B4DH59
AVYEAKLFHTNFYDT	SERPINA4	161	P29622
ITFLKDFTYSKDDFH	NR1H2	326	P55055
TKFYLEFHSSCLESF	INPP5D	746	Q92835
DHFKSLYDFSFSFLT	SH3TC2	481	Q8TF17
KAEDIDFKYHFDFFS	PGAP1	111	Q75T13
QYSEEFRIHFTFKEF	ITGAM	191	P11215
YTSFHFASLEDVQAK	SERPINB3	216	P29508
FFYRLDHTSSFSKDF	SSH1	901	Q8WYL5
LICIYFSNTHFFKDE	ADGRG5	131	Q8IZF4
SSALYEEAFTVFHKF	CLTCL1	1061	P53675
FTSVYFGHDSELFKA	NLRP9	666	Q7RTR0
FFHSLSEKYSNVIFL	TXN	41	P10599
KYFISHILAFFAASD	RRM2B	86	Q7LG56
FKAEHAGVRTYFFSA	PLEKHA6	126	Q9Y2H5
FRAHKNVLAASSEYF	ZBTB21	41	Q9ULJ3
HFHDFSVLFSVEKFL	VPS35L	556	Q7Z3J2
DKVAHFSYPFTFEAF	MKS1	366	Q9NXB0
TFTYKAAHIFFTDTC	STXBP2	96	Q15833
FSTFSHKTVYFDFQV	TMED3	106	Q9Y3Q3
SNEFSTFTHKTVYFD	TMED7	111	Q9Y3B3
TFTHKTVYFDFQVGE	TMED7	116	Q9Y3B3
FLFEKSATYFDSEVV	NDST2	671	P52849
FFAHNEYLVSEIFKA	RHAG	151	Q02094
KEDADRIHIFSSFFY	SENP6	701	Q9GZR1
FYSVEFSAHSKFLAS	ROS1	981	P08922
VSFFDAESGSHVYTF	RFPL3	256	O75679
SEYLFKFNSSFEIHD	TFDP3	276	Q5H9I0
ALAQRTYSDDHVKFF	XPOT	41	O43592
TYSDDHVKFFCFQVL	XPOT	46	O43592
SKHLTEYFAFLYEFA	USP34	2436	Q70CQ2
IESHFGSSVASYFIF	TMC2	241	Q8TDI7
YKHTTSIFDDFAHYE	YTHDF1	526	Q9BYJ9
GFFKVDYSQFHATFE	KCNJ3	336	P48549
FKAHRAVLAASSSYF	NACC1	41	Q96RE7
FAKFAATYFQGTTTH	MYO7A	1001	Q13402
ELEKFSKVTFDYASF	MYT1	576	Q01538