Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serotonin-gated monoatomic cation channel activity	HTR3D HTR3E	4.30e-05	5	42	2	GO:0022850
GeneOntologyMolecularFunction	serotonin receptor activity	HTR3D HTR3E	6.44e-05	6	42	2	GO:0099589
GeneOntologyMolecularFunction	transcription corepressor binding	NEK6 MTF2 USP11	2.59e-04	59	42	3	GO:0001222
GeneOntologyCellularComponent	mRNA cleavage and polyadenylation specificity factor complex	PIP5K1A CSNK1A1L CSNK1A1	1.76e-05	26	41	3	GO:0005847
GeneOntologyCellularComponent	mRNA cleavage factor complex	PIP5K1A CSNK1A1L CSNK1A1	3.03e-05	31	41	3	GO:0005849
GeneOntologyCellularComponent	serotonin-activated cation-selective channel complex	HTR3D HTR3E	3.74e-05	5	41	2	GO:1904602
GeneOntologyCellularComponent	serotonin receptor complex	HTR3D HTR3E	3.74e-05	5	41	2	GO:0098665
GeneOntologyCellularComponent	perisynaptic extracellular matrix	TNC PTPRZ1	2.04e-04	11	41	2	GO:0098966
GeneOntologyCellularComponent	beta-catenin destruction complex	CSNK1A1L CSNK1A1	2.89e-04	13	41	2	GO:0030877
GeneOntologyCellularComponent	synapse-associated extracellular matrix	TNC PTPRZ1	2.89e-04	13	41	2	GO:0099535
GeneOntologyCellularComponent	nuclear speck	PIP5K1A CSNK1A1L NEK6 CWC22 CSNK1A1	1.48e-03	431	41	5	GO:0016607
Domain	-	HTR3D HTR3E	1.10e-03	23	40	2	1.20.120.370
Domain	Acetylcholine_rcpt_TM	HTR3D HTR3E	1.10e-03	23	40	2	IPR027361
Domain	-	OBSCN CD1B IL1R1 TNC PTPRZ1 PLXNA1	2.68e-03	663	40	6	2.60.40.10
Domain	Ig-like_fold	OBSCN CD1B IL1R1 TNC PTPRZ1 PLXNA1	3.66e-03	706	40	6	IPR013783
Domain	Neur_chan_memb	HTR3D HTR3E	4.36e-03	46	40	2	PF02932
Domain	Neur_chan_LBD	HTR3D HTR3E	4.55e-03	47	40	2	PF02931
Domain	NEUROTR_ION_CHANNEL	HTR3D HTR3E	4.55e-03	47	40	2	PS00236
Domain	Neurotrans-gated_channel_TM	HTR3D HTR3E	4.55e-03	47	40	2	IPR006029
Domain	-	HTR3D HTR3E	4.55e-03	47	40	2	2.70.170.10
Domain	Neur_channel	HTR3D HTR3E	4.55e-03	47	40	2	IPR006201
Domain	Neur_chan_lig-bd	HTR3D HTR3E	4.55e-03	47	40	2	IPR006202
Domain	WW	SETD2 WWP2	4.55e-03	47	40	2	PF00397
Domain	WW	SETD2 WWP2	4.74e-03	48	40	2	SM00456
Domain	fn3	OBSCN TNC PTPRZ1	5.00e-03	162	40	3	PF00041
Domain	WW_DOMAIN_2	SETD2 WWP2	5.34e-03	51	40	2	PS50020
Domain	WW_DOMAIN_1	SETD2 WWP2	5.34e-03	51	40	2	PS01159
Domain	WW_dom	SETD2 WWP2	5.54e-03	52	40	2	IPR001202
Domain	ARM-type_fold	INTS4 TTI1 CWC22 UBR4	5.82e-03	339	40	4	IPR016024
Domain	VWA	VWA3A CACHD1	6.40e-03	56	40	2	PF00092
Domain	Ser/Thr_kinase_AS	OBSCN CSNK1A1L NEK6 CSNK1A1	6.97e-03	357	40	4	IPR008271
Domain	S_TKc	OBSCN CSNK1A1L NEK6 CSNK1A1	7.11e-03	359	40	4	SM00220
Domain	FN3	OBSCN TNC PTPRZ1	7.22e-03	185	40	3	SM00060
Domain	PROTEIN_KINASE_ST	OBSCN CSNK1A1L NEK6 CSNK1A1	7.32e-03	362	40	4	PS00108
Domain	Protein_kinase_ATP_BS	OBSCN CSNK1A1L NEK6 CSNK1A1	8.57e-03	379	40	4	IPR017441
Domain	Pkinase	OBSCN CSNK1A1L NEK6 CSNK1A1	8.73e-03	381	40	4	PF00069
Domain	FN3	OBSCN TNC PTPRZ1	8.81e-03	199	40	3	PS50853
Domain	FN3_dom	OBSCN TNC PTPRZ1	1.01e-02	209	40	3	IPR003961
Domain	-	VWA3A CACHD1	1.10e-02	74	40	2	3.40.50.410
Pubmed	Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.	CASP3 CSNK1A1L CSNK1A1	5.91e-07	14	42	3	39183304
Pubmed	Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	23354688
Pubmed	Tissue-specific distribution of mouse casein kinase I alpha mRNA.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	9522121
Pubmed	Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	25994086
Pubmed	CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	37723657
Pubmed	Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	36929849
Pubmed	Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	35695793
Pubmed	Exploring the role of casein kinase 1α splice variants across cancer cell lines.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	38852281
Pubmed	Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	23690993
Pubmed	Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	34216174
Pubmed	Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	37108197
Pubmed	Regulation of apoptosis by phosphatidylinositol 4,5-bisphosphate inhibition of caspases, and caspase inactivation of phosphatidylinositol phosphate 5-kinases.	CASP3 PIP5K1A	1.42e-06	2	42	2	11042212
Pubmed	Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.	CSNK1A1L CSNK1A1	1.42e-06	2	42	2	36542875
Pubmed	Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation.	CASP3 SFTPB TNC	2.48e-06	22	42	3	21513708
Pubmed	Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.	CASP3 TNC PTPRZ1	3.70e-06	25	42	3	19373938
Pubmed	Differential expression of micro-heterogeneous LewisX-type glycans in the stem cell compartment of the developing mouse spinal cord.	TNC PTPRZ1	4.27e-06	3	42	2	23624942
Pubmed	CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.	CSNK1A1L CSNK1A1	4.27e-06	3	42	2	28878021
Pubmed	Type I Interferons Control Proliferation and Function of the Intestinal Epithelium.	CSNK1A1L CSNK1A1	4.27e-06	3	42	2	26811327
Pubmed	Glypican-1, phosphacan/receptor protein-tyrosine phosphatase-ζ/β and its ligand, tenascin-C, are expressed by neural stem cells and neural cells derived from embryonic stem cells.	TNC PTPRZ1	4.27e-06	3	42	2	20689858
Pubmed	Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.	CSNK1A1L CSNK1A1	4.27e-06	3	42	2	19805514
Pubmed	Long noncoding RNA lnc-DILC stabilizes PTEN and suppresses clear cell renal cell carcinoma progression.	USP11 WWP2	4.27e-06	3	42	2	31592114
Pubmed	Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis.	CASP3 ADGRL1	4.27e-06	3	42	2	28018171
Pubmed	Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.	CSNK1A1L CSNK1A1	4.27e-06	3	42	2	24616378
Pubmed	Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.	CSNK1A1L CSNK1A1	4.27e-06	3	42	2	25242043
Pubmed	Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.	CSNK1A1L CSNK1A1	4.27e-06	3	42	2	28655862
Pubmed	Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.	HTR3D HTR3E	4.27e-06	3	42	2	21192076
Pubmed	Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E.	HTR3D HTR3E	4.27e-06	3	42	2	12801637
Pubmed	Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression.	CASP3 CSNK1A1L CSNK1A1	7.19e-06	31	42	3	37168577
Pubmed	Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.	CSNK1A1L CSNK1A1	8.53e-06	4	42	2	38147624
Pubmed	The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.	CSNK1A1L CSNK1A1	8.53e-06	4	42	2	32728212
Pubmed	A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain.	TNC PTPRZ1	8.53e-06	4	42	2	9753681
Pubmed	Tenascin-C is an inhibitory boundary molecule in the developing olfactory bulb.	TNC PTPRZ1	8.53e-06	4	42	2	19641104
Pubmed	A cluster of novel serotonin receptor 3-like genes on human chromosome 3.	HTR3D HTR3E	8.53e-06	4	42	2	14597179
Pubmed	FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning.	CSNK1A1L CSNK1A1	8.53e-06	4	42	2	31338967
Pubmed	Cx43 phosphorylation sites regulate pancreatic cancer metastasis.	CSNK1A1L CSNK1A1	8.53e-06	4	42	2	33603164
Pubmed	Regulation of p53-MDMX interaction by casein kinase 1 alpha.	CSNK1A1L CSNK1A1	8.53e-06	4	42	2	16024788
Pubmed	A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.	CSNK1A1L CSNK1A1	8.53e-06	4	42	2	30487124
Pubmed	Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.	HTR3D HTR3E	8.53e-06	4	42	2	20602613
Pubmed	Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development.	CASP3 SETD2	1.42e-05	5	42	2	32169821
Pubmed	Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice.	CSNK1A1L CSNK1A1	1.42e-05	5	42	2	30064974
Pubmed	Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E.	HTR3D HTR3E	1.42e-05	5	42	2	17392525
Pubmed	A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.	CSNK1A1L CSNK1A1	1.42e-05	5	42	2	23890787
Pubmed	Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia.	HTR3D HTR3E	1.42e-05	5	42	2	19794330
Pubmed	CK1α deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3β pathway and inhibiting Foxa2 expression through p53 pathway†.	CSNK1A1L CSNK1A1	1.42e-05	5	42	2	37944068
Pubmed	Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1α S-glutathionylation during posterior capsular opacification.	CSNK1A1L CSNK1A1	1.42e-05	5	42	2	36989576
Pubmed	Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth.	TNC PTPRZ1	1.42e-05	5	42	2	12700241
Pubmed	CKIα ablation highlights a critical role for p53 in invasiveness control.	CSNK1A1L CSNK1A1	1.42e-05	5	42	2	21331045
Pubmed	Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome.	CSNK1A1L CSNK1A1	1.42e-05	5	42	2	30651631
Pubmed	A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.	HTR3D HTR3E	1.42e-05	5	42	2	20356718
Pubmed	Differential expression of phosphacan/RPTPbeta isoforms in the developing mouse visual system.	TNC PTPRZ1	1.42e-05	5	42	2	17722031
Pubmed	Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.	CSNK1A1L CSNK1A1	1.42e-05	5	42	2	25628462
Pubmed	Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome.	CASP3 SFTPB	2.13e-05	6	42	2	33219378
Pubmed	CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs.	PIP5K1A CSNK1A1	2.13e-05	6	42	2	18305108
Pubmed	Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways.	CSNK1A1L CSNK1A1	2.13e-05	6	42	2	11884395
Pubmed	Physiological role for casein kinase 1 in glutamatergic synaptic transmission.	CSNK1A1L CSNK1A1	2.13e-05	6	42	2	16014721
Pubmed	p600 Plays Essential Roles in Fetal Development.	CASP3 UBR4	2.13e-05	6	42	2	23824717
Pubmed	MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.	CSNK1A1L CSNK1A1	2.13e-05	6	42	2	33667384
Pubmed	Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.	CSNK1A1L CSNK1A1	2.13e-05	6	42	2	15687492
Pubmed	Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.	CSNK1A1L CSNK1A1	2.13e-05	6	42	2	19118383
Pubmed	Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy.	HTR3D HTR3E	2.13e-05	6	42	2	20021265
Pubmed	MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling.	CSNK1A1L CSNK1A1	2.13e-05	6	42	2	32511789
Pubmed	Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.	CSNK1A1L CSNK1A1	2.98e-05	7	42	2	25644602
Pubmed	Gene expression changes during the development of acute lung injury: role of transforming growth factor beta.	SFTPB TNC	2.98e-05	7	42	2	16100012
Pubmed	Interleukin-1β enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes.	CASP3 IL1R1	2.98e-05	7	42	2	25551609
Pubmed	The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway.	CSNK1A1L CSNK1A1	2.98e-05	7	42	2	17686994
Pubmed	p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex.	CASP3 UBR4	2.98e-05	7	42	2	24812355
Pubmed	NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly.	CSNK1A1L CSNK1A1	2.98e-05	7	42	2	34615873
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	TTI1 CWC22 CSNK1A1 USP11 UBR4	3.03e-05	300	42	5	28561026
Pubmed	Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin.	CSNK1A1L CSNK1A1	3.97e-05	8	42	2	17101137
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	CSNK1A1L CSNK1A1	3.97e-05	8	42	2	21930935
Pubmed	Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.	CSNK1A1L CSNK1A1	3.97e-05	8	42	2	17244647
Pubmed	Semaphorin-Mediated Corticospinal Axon Elimination Depends on the Activity-Induced Bax/Bak-Caspase Pathway.	CASP3 PLXNA1	3.97e-05	8	42	2	32471877
Pubmed	NKCC1-Deficiency Results in Abnormal Proliferation of Neural Progenitor Cells of the Lateral Ganglionic Eminence.	CASP3 SLC12A2	3.97e-05	8	42	2	27582690
Pubmed	ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.	CASP3 UGT8 TNC	5.08e-05	59	42	3	31924792
Pubmed	Effects of Fam83h truncation mutation on enamel developmental defects in male C57/BL6J mice.	CSNK1A1L CSNK1A1	5.10e-05	9	42	2	36272714
Pubmed	Tenascin C regulates proliferation and differentiation processes during embryonic retinogenesis and modulates the de-differentiation capacity of Müller glia by influencing growth factor responsiveness and the extracellular matrix compartment.	TNC PTPRZ1	5.10e-05	9	42	2	22691363
Pubmed	Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum.	CASP3 TNC	5.10e-05	9	42	2	35557949
Pubmed	A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.	CASP3 IL1R1	5.10e-05	9	42	2	32561755
Pubmed	Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.	CSNK1A1L CSNK1A1	5.10e-05	9	42	2	9601641
Pubmed	Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.	CSNK1A1L CSNK1A1	6.37e-05	10	42	2	25500533
Pubmed	Widespread neuronal ectopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice.	TNC PTPRZ1	6.37e-05	10	42	2	9184108
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	CSNK1A1L NEK6 CSNK1A1 POLG	6.38e-05	178	42	4	27637333
Pubmed	β-Catenin in stromal progenitors controls medullary stromal development.	CASP3 TNC	7.78e-05	11	42	2	29357412
Pubmed	Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex.	CSNK1A1L CSNK1A1	7.78e-05	11	42	2	21709260
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	USP11 WWP2	7.78e-05	11	42	2	22773947
Pubmed	Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice.	CASP3 SFTPB	9.32e-05	12	42	2	23980576
Pubmed	Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation.	SLC12A2 IL1R1	9.32e-05	12	42	2	25959047
Pubmed	Peli1 Modulates the Subcellular Localization and Activity of Mdmx.	CSNK1A1L CSNK1A1	9.32e-05	12	42	2	29523541
Pubmed	Functional assembly of accessory optic system circuitry critical for compensatory eye movements.	CASP3 PLXNA1	1.10e-04	13	42	2	25959730
Pubmed	Endothelial marker-expressing stromal cells are critical for kidney formation.	CASP3 TNC	1.10e-04	13	42	2	28539333
Pubmed	Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.	CASP3 TNC	1.28e-04	14	42	2	31475747
Pubmed	β3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium.	CASP3 PLXNA1	1.28e-04	14	42	2	21525298
Pubmed	Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice.	CASP3 PLXNA1	1.28e-04	14	42	2	25975775
Pubmed	Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring.	CASP3 TNC	1.28e-04	14	42	2	29593327
Pubmed	Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment.	CASP3 SFTPB	1.48e-04	15	42	2	23405202
Pubmed	Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice.	CASP3 TNC	1.48e-04	15	42	2	19961580
Pubmed	Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.	CSNK1A1L CSNK1A1	1.48e-04	15	42	2	18827223
Pubmed	Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.	CASP3 SLC12A2	1.48e-04	15	42	2	35379995
Pubmed	The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.	CSNK1A1L CSNK1A1	1.69e-04	16	42	2	19576224
Pubmed	Specific glial populations regulate hippocampal morphogenesis.	CASP3 TNC	1.69e-04	16	42	2	19020026
Cytoband	3q27.1	HTR3D HTR3E	2.83e-04	27	42	2	3q27.1
GeneFamily	5-hydroxytryptamine receptors, ionotropic	HTR3D HTR3E	2.48e-05	5	29	2	172
GeneFamily	Fibronectin type III domain containing	OBSCN TNC PTPRZ1	2.10e-03	160	29	3	555
Coexpression	SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP	CASP3 PIP5K1A SETD2 TNC CSNK1A1	6.52e-06	169	41	5	M40877
Coexpression	RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN	MED14 CASP3 CD1B IL1R1 PLXNA1	4.29e-05	250	41	5	M13333
Coexpression	SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX2_UP	CSNK1A1L CSNK1A1	4.99e-05	7	41	2	MM567
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1A1L CSNK1A1	4.13e-05	7	42	2	DOID:0060807 (implicated_via_orthology)
Disease	amyotrophic lateral sclerosis (biomarker_via_orthology)	CASP3 PTPRZ1	1.53e-04	13	42	2	DOID:332 (biomarker_via_orthology)
Disease	status epilepticus (biomarker_via_orthology)	CASP3 PTPRZ1 POLG	3.94e-04	100	42	3	DOID:1824 (biomarker_via_orthology)
Disease	mean platelet volume	INTS4 QRFPR HTR3D SETD2 ACTL6B NT5DC4 CWC22	5.41e-04	1020	42	7	EFO_0004584
Disease	pulmonary tuberculosis	PIP5K1A CWC22	7.84e-04	29	42	2	EFO_1000049
Disease	visual epilepsy (implicated_via_orthology)	NCF2 SLC12A2	1.08e-03	34	42	2	DOID:11832 (implicated_via_orthology)
Disease	lung cancer (is_marker_for)	SFTPB TNC	1.42e-03	39	42	2	DOID:1324 (is_marker_for)
Disease	Endometrioma	MED14 IL1R1 TNC	1.57e-03	161	42	3	C0269102
Disease	Endometriosis	MED14 IL1R1 TNC	1.57e-03	161	42	3	C0014175
Disease	middle cerebral artery infarction (implicated_via_orthology)	CASP3 SLC12A2	1.88e-03	45	42	2	DOID:3525 (implicated_via_orthology)
Disease	severe acute respiratory syndrome (is_marker_for)	CASP3 IL1R1	2.05e-03	47	42	2	DOID:2945 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MKVDSICNLDIFYFP	HTR3E	156	A5X5Y0
LMFEQYNIPAFFLCK	ACTL6B	136	O94805
FQMENVQCYLPDAFK	ADGRL1	76	O94910
YFYKVLMDLLPVCNQ	CACHD1	816	Q5VU97
FQMKYPFEIQGIAGC	CD1B	106	P29016
YPEMGLCIIINNKNF	CASP3	41	P42574
VQCLQKPMLFGDRFY	MTF2	231	Q9Y483
MNPGYDCLFKLLLIG	RAB1C	1	Q92928
ICNPIVYAFMNENFK	QRFPR	326	Q96P65
PLFGMCEKFLQEVDF	INTS4	746	Q96HW7
MFNGQKGLVPCNYLE	NCF2	281	P19878
CLNPMLYVFVGQDFR	FPR2	296	P25090
FFQELCEYMGLPKLN	CWC22	586	Q9HCG8
KFLKECAGEPLFMLY	PLXNA1	1451	Q9UIW2
RCMFAYKLGLNDLPQ	POLG	1161	P54098
PFYGDKMNLFSLCQK	NEK6	246	Q9HC98
EVLCKGFPAEFAMYL	CSNK1A1L	246	Q8N752
CYLPNLKVMLGNFKS	PRSS37	56	A4D1T9
GQKFPLEMQIYCFDA	PTPRZ1	146	P23471
PDGLFLDADMYNALC	PIP5K1A	291	Q99755
RLFADEKPLQDMYNC	MED14	281	O60244
LQLFPCAKYQMVQDG	OBSCN	4016	Q5VST9
DLQCFYILNMLFNLP	NT5DC4	116	Q86YG4
KFDLLLVDPNDMCGF	UGT8	131	Q16880
VCPYMEFFKNENNEL	IL1R1	141	P14778
VYEKPEDPLNFMLCQ	TEX55	521	Q96M34
KLLMPQCNQVLDDYF	SFTPB	106	P07988
PLYQFMSCKEFDDLF	TADA2B	261	Q86TJ2
EFLGQYTLPLLCMNK	PLCZ1	566	Q86YW0
EVLCKGFPAEFAMYL	CSNK1A1	246	P48729
FYLPLESGNCAPFKM	HTR3D	251	Q70Z44
VLNPMYCLFEYAGKN	WWP2	571	O00308
FLKPEDENYQMCEGI	VPS13A	2036	Q96RL7
MAKVLLDNYCFPENL	RBP3	31	P10745
LDNYCFPENLLGMQE	RBP3	36	P10745
FNMLEELYLQPDQKF	RLF	426	Q13129
FQALCKDNIYPAFQM	SLC12A2	626	P55011
LLYPFPKDCSQAMLN	TNC	1976	P24821
QGKMPCYFDLIEENV	SETD2	1466	Q9BYW2
MQILVERFKPYCNFD	UBR4	4631	Q5T4S7
CYLEELNFRNPLGMK	USP11	341	P51784
QLNVCLFYVGEPKMD	VWA3A	641	A6NCI4
QFAYALGKDFCLLLM	TTI1	636	O43156