Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessotic vesicle development

STOX1 SIX1 PROX1

1.32e-0517573GO:0071599
GeneOntologyBiologicalProcessregulation of brown fat cell differentiation

MTOR TRPV4 SIX1

6.95e-0529573GO:0090335
GeneOntologyBiologicalProcessolfactory placode morphogenesis

SIX1 PROX1

7.46e-055572GO:0071699
GeneOntologyBiologicalProcessolfactory placode development

SIX1 PROX1

7.46e-055572GO:0071698
GeneOntologyBiologicalProcessolfactory placode formation

SIX1 PROX1

7.46e-055572GO:0030910
GeneOntologyBiologicalProcessembryonic morphogenesis

HOXA3 CACNA1C NCOA3 COL5A2 PRICKLE1 STOX1 SIX1 PROX1 FOXC2

1.36e-04713579GO:0048598
GeneOntologyBiologicalProcessembryonic organ development

HOXA3 NCOA3 PRICKLE1 POLE STOX1 SIX1 PROX1 FOXC2

1.46e-04561578GO:0048568
GeneOntologyCellularComponentTORC2 complex

MTOR SESN3

2.60e-049572GO:0031932
GeneOntologyCellularComponentTOR complex

MTOR SESN3

4.74e-0412572GO:0038201
Domain-

NLN THOP1

2.64e-0535621.20.1050.40
DomainPept_M3A_M3B

NLN THOP1

2.64e-053562IPR001567
DomainPeptidase_M3

NLN THOP1

2.64e-053562PF01432
Domain-

NLN THOP1

2.64e-0535621.10.1370.10
DomainNeurolysin/TOP_N

NLN THOP1

2.64e-053562IPR024080
DomainNeurolysin/TOP_dom2

NLN THOP1

2.64e-053562IPR024077
DomainCadherin_tail

PCDHGA6 PCDHGA1

5.50e-0337562PF15974
DomainCadherin_CBD

PCDHGA6 PCDHGA1

5.50e-0337562IPR031904
DomainCadherin_C

PCDHGA6 PCDHGA1

7.04e-0342562IPR032455
DomainCadherin_C_2

PCDHGA6 PCDHGA1

7.04e-0342562PF16492
Pubmed

Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth.

NLN THOP1

2.64e-06257217620116
Pubmed

Prox1 and FOXC2 act as regulators of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma.

PROX1 FOXC2

2.64e-06257224647631
Pubmed

Defects in vein valve PROX1/FOXC2 antithrombotic pathway in endothelial cells drive the hypercoagulable state induced by trauma and critical illness.

PROX1 FOXC2

2.64e-06257237072887
Pubmed

Prox-1 and FOXC2 gene expression in adipose tissue: A potential contributory role of the lymphatic system to familial combined hyperlipidaemia.

PROX1 FOXC2

2.64e-06257219339011
Pubmed

ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.

ESRRG KCNN1

2.64e-06257238912580
Pubmed

Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase.

NLN THOP1

2.64e-06257217251185
Pubmed

PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway.

MTOR PROX1

7.91e-06357237224811
Pubmed

Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.

MTOR SESN3

7.91e-06357237918578
Pubmed

Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis.

PROX1 FOXC2

7.91e-06357231710307
Pubmed

Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation.

PROX1 FOXC2

7.91e-06357232510325
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

HOXA3 CSDE1 NCOA3 ANKEF1 SS18L1 ESRRG MLLT10 SIX1 PROX1

1.20e-0587757920211142
Pubmed

Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.

PROX1 FOXC2

1.58e-05457219825936
Pubmed

Foxo1 deletion promotes the growth of new lymphatic valves.

PROX1 FOXC2

1.58e-05457234263740
Pubmed

Dynamic coupling between TRPV4 and Ca2+-activated SK1/3 and IK1 K+ channels plays a critical role in regulating the K+-secretory BK channel in kidney collecting duct cells.

KCNN1 TRPV4

2.63e-05557228274924
Pubmed

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.

MTOR SESN3

2.63e-05557220412774
Pubmed

eNOS Regulates Lymphatic Valve Specification by Controlling β-Catenin Signaling During Embryogenesis in Mice.

PROX1 FOXC2

2.63e-05557237767708
Pubmed

Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase.

NLN NNT

2.63e-05557216497723
Pubmed

Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling.

PROX1 FOXC2

3.94e-05657226079578
Pubmed

Integrative transcriptomic profiling of ncRNAs and mRNAs in developing mouse lens.

PROX1 FOXC2

3.94e-05657238933921
Pubmed

A lymphatic defect causes ocular hypertension and glaucoma in mice.

PROX1 FOXC2

3.94e-05657225202984
Pubmed

Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning.

MLLT10 SIX1

5.51e-05757228280206
Pubmed

Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation.

PROX1 FOXC2

5.51e-05757227214551
Pubmed

Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation.

PROX1 FOXC2

5.51e-05757223741013
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

HOXA3 NCOA3 ESRRG SIX1 PROX1

7.23e-0526357520932939
Pubmed

Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation.

PROX1 FOXC2

7.34e-05857230482854
Pubmed

Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow.

PROX1 FOXC2

7.34e-05857232182215
Pubmed

Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome.

PROX1 FOXC2

7.34e-05857215465483
Pubmed

Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.

PROX1 FOXC2

9.43e-05957228705793
Pubmed

Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling.

MTOR PROX1

9.43e-05957228974734
Pubmed

A census of human transcription factors: function, expression and evolution.

HOXA3 NCOA3 NKX2-4 ESRRG AKNA SIX1 PROX1 FOXC2

1.12e-0490857819274049
Pubmed

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1.

PROX1 FOXC2

1.18e-041057219398761
Pubmed

Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves.

PROX1 FOXC2

1.18e-041057222012621
Pubmed

GATA2 is required for lymphatic vessel valve development and maintenance.

PROX1 FOXC2

1.44e-041157226214525
Pubmed

Mutations in EPHB4 cause human venous valve aplasia.

PROX1 FOXC2

1.44e-041157234403370
Pubmed

Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo.

PROX1 FOXC2

1.44e-041157224361262
Pubmed

Differential gene expression in the developing mouse ureter.

COL5A2 FOXC2

1.72e-041257216459152
Pubmed

Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.

PROX1 FOXC2

1.72e-041257215322537
Pubmed

Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels.

PROX1 FOXC2

1.72e-041257233934370
Pubmed

Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid.

HOXA3 SIX1

2.03e-041357212070080
Pubmed

VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance.

PROX1 FOXC2

2.03e-041357231461654
Pubmed

YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling.

PROX1 FOXC2

2.03e-041357233060128
Pubmed

Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves.

PROX1 FOXC2

2.03e-041357227313318
Pubmed

Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling.

PROX1 FOXC2

2.03e-041357230332639
Pubmed

The transcription factor Foxf1 binds to serum response factor and myocardin to regulate gene transcription in visceral smooth muscle cells.

CACNA1C CNN1

2.03e-041357223946491
Pubmed

Tie1 is required for lymphatic valve and collecting vessel development.

PROX1 FOXC2

2.37e-041457225576926
Pubmed

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1.

HOXA3 SIX1

2.73e-041557216530750
Pubmed

DNA cloning using in vitro site-specific recombination.

CSDE1 ZNF280D ABLIM3 NNT MTMR10 PRLR FOXC2

3.09e-0479457711076863
Pubmed

Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.

MTOR PROX1

3.12e-041657236440598
Pubmed

Hdac3 regulates lymphovenous and lymphatic valve formation.

PROX1 FOXC2

3.12e-041657229035278
Pubmed

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.

PROX1 FOXC2

3.12e-041657226027726
Pubmed

Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice.

PROX1 FOXC2

3.12e-041657226953188
Pubmed

Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PROX1 FOXC2

3.12e-041657228179430
Pubmed

Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.

PROX1 FOXC2

3.12e-041657226542011
Pubmed

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis.

SIX1 CNN1

3.12e-041657221364285
Pubmed

Genome-scale RNAi screen for host factors required for HIV replication.

POLE EIF4A2 NPAP1 CR2 CLDN6

3.15e-0436157518976975
Pubmed

Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax.

PROX1 FOXC2

3.53e-041757221515254
Pubmed

Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.

PROX1 FOXC2

3.53e-041757222306086
Pubmed

The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.

PROX1 FOXC2

3.97e-041857216678147
Pubmed

GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126.

PROX1 FOXC2

3.97e-041857231582413
Pubmed

A systematic study of nuclear interactome of C-terminal domain small phosphatase-like 2 using inducible expression system and shotgun proteomics.

NCOA3 ILF3

3.97e-041857226674342
Pubmed

Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.

PROX1 FOXC2

3.97e-041857219686679
Pubmed

Lymph sacs are not required for the initiation of lymph node formation.

CR2 PROX1

4.43e-041957219060331
Pubmed

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.

MTOR PROX1

4.43e-041957227246713
Pubmed

Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.

ESRRG SIX1

4.43e-041957220395239
Pubmed

Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.

CR2 CNN1

4.92e-042057230988302
Pubmed

CHD7 regulates cardiovascular development through ATP-dependent and -independent activities.

CNN1 FOXC2

4.92e-042057233127760
Pubmed

Multiple roles of lymphatic vessels in peripheral lymph node development.

PROX1 FOXC2

4.92e-042057230355615
Pubmed

SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis.

ABLIM3 FOXC2

5.43e-042157230021842
Pubmed

Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity.

ESRRG PROX1

5.97e-042257238160393
Pubmed

Gene-environment interaction impacts on heart development and embryo survival.

CACNA1C PROX1

5.97e-042257230787001
Pubmed

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

CSDE1 ESRRG ABLIM3

6.03e-0410057310048485
Pubmed

Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels.

CNN1 PROX1

6.53e-042357229237738
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

ILF3 HNRNPLL CNN1 PPM1B

7.08e-0424557435652658
Pubmed

Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.

MTOR PROX1

7.12e-042457232043969
Pubmed

Overlapping functions of SIX homeoproteins during embryonic myogenesis.

SIX1 CNN1

7.12e-042457237267426
Pubmed

Regulation of planar cell polarity by Smurf ubiquitin ligases.

PRICKLE1 PPM1B

7.73e-042557219379695
Pubmed

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.

ILF3 MTOR

7.73e-042557230340022
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

CSDE1 ILF3 HNRNPLL PPM1B

8.58e-0425857437794589
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

PRR12 ILF3 POLE SS18L1 CDK19

8.80e-0445357529656893
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

CSDE1 DNAJB12 ILF3 EIF4A2 HNRNPLL

9.60e-0446257531138677
Pubmed

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.

TRPV4 CNN1

1.04e-032957225535917
Pubmed

Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.

NLN PRLR

1.11e-033057238310234
Pubmed

The LIFEdb database in 2006.

CSDE1 ZNF280D ABLIM3 NNT MTMR10 PRLR

1.14e-0372057616381901
Pubmed

From ORFeome to biology: a functional genomics pipeline.

CSDE1 ZNF280D ABLIM3 NNT MTMR10 PRLR

1.16e-0372257615489336
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

CSDE1 PGGHG MTOR ANKEF1 ESRRG ACBD5 ABLIM3 PRLR

1.17e-03129357815342556
Pubmed

Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.

MTOR SIX1

1.27e-033257234193412
Pubmed

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.

PROX1 FOXC2

1.35e-033357218424556
Pubmed

The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.

NCOA3 ILF3

1.35e-033357232140074
Pubmed

Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.

NCOA3 ESRRG PROX1

1.38e-0313357315604093
Cytoband10q22.1

DNAJB12 STOX1

1.51e-034657210q22.1
ToppCellAdult-Mesenchymal-chondrocyte-D122|Adult / Lineage, Cell type, age group and donor

CACNA1C COL5A2 A2ML1 RHBDD3 ABLIM3

1.31e-0614857581a1e6fdd942a612bf523c59b8b4974f6ca1fdce
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 ATP13A5 SIX1 CNN1

2.45e-06168575b220e732eb7b204fc263a9f2e8ddae6bf9fa98f4
ToppCellSubstantia_nigra-Endothelial-MURAL|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 ATP13A5 SIX1 CNN1

2.45e-06168575271a81c59a9a75bac6107c68fead03e7f35bc192
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HOXA3 CACNA1C COL5A2 ABLIM3 ADAMTSL2

5.73e-06200575e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Fos_(Mural.Rgs5Acta2.Fos)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

XIRP1 SIX1 CNN1 FOXC2

1.01e-0510557473639bfa677c7bb9e5166aa09eabaf1b05bb89a0
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Fos_(Mural.Rgs5Acta2.Fos)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

XIRP1 SIX1 CNN1 FOXC2

1.01e-0510557484b639eb44f71d1e12bb7850b9063d80e73cb741
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)|Thalamus / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 ATP13A5 SIX1

2.06e-05126574333f83f9ba64d46f22fee328d0a691fd5818bdac
ToppCellThalamus-Endothelial-MURAL|Thalamus / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 ATP13A5 SIX1

2.06e-05126574cf571f36761da3540fb445de89d555cbce8a47ab
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

XIRP1 SIX1 CNN1 FOXC2

2.13e-051275748c972ea21797ee46d6c67e91cfd2e2e2ce016248
ToppCellStriatum-Neuronal-Inhibitory|Striatum / BrainAtlas - Mouse McCarroll V32

CR2 ABLIM3 C1orf94 PRLR

4.88e-05157574c41ff3fe9de7187575114febfe9bd8733366fb8a
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

HOXA3 CACNA1C CNN1 FOXC2

5.00e-051585748d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCellAdult-Mesenchymal-myofibroblast_cell-D122|Adult / Lineage, Cell type, age group and donor

CACNA1C COL5A2 ADAMTSL2 FOXC2

5.00e-05158574410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A2 ESRRG ATP13A5 C1orf94

5.25e-05160574c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A2 ESRRG ATP13A5 C1orf94

5.25e-0516057425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

POLE TRPV4 SIX1 FOXC2

5.38e-051615749703b7e67d9fadb6129cad166bd01be915042e44
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1C POLE ATP13A5 PRLR

5.51e-05162574bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C PCDHGA1 CNN1 FOXC2

5.92e-051655748a82e20c9b1156bb4bbc16f7785abb04458d671b
ToppCellAdult-Mesenchymal-myofibroblast_cell|Adult / Lineage, Cell type, age group and donor

CACNA1C COL5A2 ADAMTSL2 FOXC2

6.20e-05167574d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCellBronchial_Brush-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

C1orf94 PRLR ADAMTSL2 PROX1

7.11e-05173574e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCellBronchial_Brush-Epithelial-Ionocytes|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

C1orf94 PRLR ADAMTSL2 PROX1

7.11e-05173574f2a8f4918c1fb68d98bc3f33cd624de0f0f11e06
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THOP1 MTOR AKNA TRIM36

7.44e-05175574bb058e714d21a0ec8532eaf3c7dd2faf78016bc0
ToppCellEntopeduncular-Endothelial-MURAL|Entopeduncular / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 ATP13A5 CNN1

7.60e-05176574b8e52bec78876562a25f0b0de502aa9372b28bd2
ToppCellwk_08-11-Mesenchymal-Chondrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

PRICKLE1 PCDHGA1 SIX1 FOXC2

7.60e-051765741af28b701c4598ce761f85adbd5d79e4918d265a
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 ATP13A5 CNN1

7.60e-0517657410c1f31c27e54b70f58f0b0086ac74dee2ce4197
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

XIRP1 SIX1 CR2 CNN1

7.77e-051775744553ee8cd9c24db6511b09fe49ed11a89e7cde9e
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A2 PCDHGA6 CNN1 ADAMTSL2

7.94e-0517857409475e522dc1b8cf9ff1c25de5d1e3082b162948
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A2 PCDHGA6 CNN1 ADAMTSL2

7.94e-0517857435de8f791b0e78a6caf52ff095f05e204a59e828
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A2 PCDHGA6 CNN1 ADAMTSL2

7.94e-05178574000d25f3f13cc76cf39c46c312c6fafc2ea4f368
ToppCellCOVID-19-kidney-Bcells|kidney / Disease (COVID-19 only), tissue and cell type

NCOA3 AKNA SESN3 CR2

8.29e-051805745650fc7ebcdf5e0be9a217a58d36a8386d59fd1b
ToppCellCOVID-19-Heart-CM_3|Heart / Disease (COVID-19 only), tissue and cell type

CACNA1C XIRP1 ESRRG CNN1

8.66e-05182574287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

CACNA1C XIRP1 ESRRG CNN1

9.03e-05184574ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2-VSMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNA1C NKX2-4 CNN1 FOXC2

9.41e-05186574c7885fd6dc7dc8fffc96f0112c51a365cf8a8f80
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D175|Adult / Lineage, Cell type, age group and donor

CACNA1C COL5A2 PRICKLE1 ADAMTSL2

9.61e-05187574e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRICKLE1 ABLIM3 PROX1 FOXC2

9.81e-05188574524a12f433c7b6f33fad36c0716afa06cd3235e9
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRICKLE1 ABLIM3 PROX1 FOXC2

9.81e-05188574d2610b81b3c7f22977b5e2137b1f61410fc4ef16
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CACNA1C PRICKLE1 CNN1 ADAMTSL2

1.00e-04189574da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

CACNA1C XIRP1 ESRRG CNN1

1.00e-041895740a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

CACNA1C XIRP1 ESRRG CNN1

1.02e-0419057493c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C XIRP1 SS18L1 CNN1

1.04e-041915748e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 PRICKLE1 CNN1 ADAMTSL2

1.04e-04191574107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C XIRP1 CNN1 FOXC2

1.04e-041915748597a8af294f24496c317d995f07eb5dcc25c13c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 PRICKLE1 CNN1 ADAMTSL2

1.04e-04191574bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C COL5A2 ABLIM3 ADAMTSL2

1.09e-0419357499525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

CACNA1C PRICKLE1 ESRRG CNN1

1.11e-0419457489812fb164065041357bb37a3c2d87028ec3de4e
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C COL5A2 ABLIM3 ADAMTSL2

1.11e-04194574e93de9428c986b8943fc169258847c650cfab0e5
ToppCell21-Trachea-Mesenchymal|Trachea / Age, Tissue, Lineage and Cell class

HOXA3 COL5A2 ABLIM3 CNN1

1.11e-04194574749dd8113ef260e00facac09de9861d61725124a
ToppCellLAM-LAM|LAM / Condition, Lineage and Cell class

CACNA1C ASB10 CNN1 PRLR

1.11e-041945744c6561a64711c72c4ef4a3e67c41d2e8d31fba57
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C XIRP1 SS18L1 CNN1

1.11e-04194574b8a130ffae68ffe550bf335460a1ec1035cf8d8d
ToppCellLAM-LAM-LAM+|LAM / Condition, Lineage and Cell class

CACNA1C ASB10 CNN1 PRLR

1.11e-041945744ba73a9145ed44896e359f6df9c1f32bbe24a189
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 SS18L1 CNN1 FOXC2

1.13e-041955740bdf845939bc4b8cc94f2808aea60f818425b076
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Cd9_(Mural.Rgs5Acta2.Cd9)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

XIRP1 KRT82 CNN1

1.17e-04745737c7e45cf219b0be5cf0d0e5ea5daeb32284c8ccd
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Cd9_(Mural.Rgs5Acta2.Cd9)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

XIRP1 KRT82 CNN1

1.17e-04745736183baf43010268f54a6db9332296338f4f74009
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C COL5A2 CNN1 FOXC2

1.17e-04197574bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCellBronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C XIRP1 CNN1 FOXC2

1.20e-04198574705118a5db366b43ffd3389c60e4cb392ad3f2e6
ToppCellbackground-Hepatic_Stellate_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

CACNA1C COL5A2 ESRRG ADAMTSL2

1.20e-04198574bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCellParenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C COL5A2 CNN1 FOXC2

1.22e-041995747c272a1aa7f3e931ad5d20809719d85b3bce4cb0
ToppCellTracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C XIRP1 CNN1 FOXC2

1.22e-04199574056a28c36cd58dc695a5ae6f29b62135d6aad819
ToppCellParenchymal-10x5prime-Stromal-Myofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C COL5A2 CNN1 FOXC2

1.22e-0419957420f760d92c351a1dac4cc0a424c443ea03a179fe
ToppCellBronchial-10x5prime-Stromal-Myofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C XIRP1 CNN1 FOXC2

1.22e-04199574ad75e5e26c37a97331164d7f77235ebd9a933a44
ToppCellParenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C COL5A2 CNN1 FOXC2

1.24e-0420057438190e4b32f7469df1da7d130bca6d7b12a3dd06
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_3|Control_saline / Treatment groups by lineage, cell group, cell type

COL5A2 ASB10 CNN1 FOXC2

1.24e-04200574b0866b497aa71d06cef25f9a335fa584e95fa7e0
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C COL5A2 PRICKLE1 ADAMTSL2

1.24e-04200574fb53be20392a8309a7393774c774a1b1aec6e676
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Mesoderm|1m / Sample Type, Dataset, Time_group, and Cell type.

HOXA3 LCA5L ABLIM3 CNN1

1.24e-04200574c0ad32e9dd7f481c2665587fd8bd9fffc2e725f9
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C COL5A2 PRICKLE1 ADAMTSL2

1.24e-0420057458b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)-|Thalamus / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 CNN1

2.03e-0489573442931182f7eb87f16c19774607eb14b44cd7ec7
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1|Thalamus / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 CNN1

2.03e-048957305ba2c31bb4bd8c7ad4bcbbefe818c08136101b2
ToppCellThalamus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)|Thalamus / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 CNN1

2.03e-04895732c19e2dc979d0f86539a044ae49f126caff50fbb
ToppCellPosterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Acta2Rgs5.Acta2_(Mural.Acta2Rgs5.Acta2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 CNN1

2.09e-0490573d809ebc50917aaf13e693b21c8faa399103e7abe
ToppCellPosterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Acta2Rgs5.Acta2_(Mural.Acta2Rgs5.Acta2)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 CNN1

2.09e-04905736b94b1b05d45ecdc2ac9d5445d244dac96d60c22
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 CNN1

2.53e-0496573cd0b9812727cad937cf840360a87a2382e570d39
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)|Hippocampus / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 CNN1

2.53e-0496573f31bed26ed9bcaf82d443de304372991136b11e7
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

XIRP1 ASB10 CNN1

2.53e-049657331ed9e073e30d740b46c8b3f01ba0de94a701995
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cbr2_(Mural.Rgs5Acta2.Cbr2)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

XIRP1 SIX1 CNN1

2.77e-04995730e2f6ba2261cc289f8f4aec5aac3051f6321e041
ToppCellSubstantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cbr2_(Mural.Rgs5Acta2.Cbr2)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

XIRP1 SIX1 CNN1

2.77e-0499573ce9d6d9b82bdc1ebb58b0b6e04abfb022dd1de88
Diseasetemporal lobe epilepsy (implicated_via_orthology)

PRICKLE1 MTOR

1.26e-049562DOID:3328 (implicated_via_orthology)
Diseasechildhood trauma measurement, alcohol consumption measurement

DNAJB12 PCDHGA6 PCDHGA1

3.38e-0471563EFO_0007878, EFO_0007979
DiseaseSchwartz-Jampel Syndrome, Type 1

TRPV4 ADAMTSL2

4.17e-0416562C4551479
DiseaseSpondyloepiphyseal Dysplasia

TRPV4 ADAMTSL2

4.17e-0416562C0038015
DiseaseAbnormal behavior

PRR12 TRPV4

4.17e-0416562C0233514
DiseaseSchwartz-Jampel Syndrome

TRPV4 ADAMTSL2

4.17e-0416562C0036391
DiseaseMelnick-Needles Syndrome

TRPV4 ADAMTSL2

4.17e-0416562C0025237
DiseaseSpondyloepiphyseal Dysplasia Tarda, X-Linked

TRPV4 ADAMTSL2

4.17e-0416562C3541456
DiseaseVan Buchem disease

TRPV4 ADAMTSL2

4.72e-0417562C0432272
DiseaseDyschondroplasias

TRPV4 ADAMTSL2

5.93e-0419562C0013366
DiseaseOsteochondrodysplasias

TRPV4 ADAMTSL2

5.93e-0419562C0029422
DiseaseMultiple Epiphyseal Dysplasia

TRPV4 ADAMTSL2

6.58e-0420562C0026760
Diseasemyeloperoxidase (MPO)-DNA complex measurement

CDK19 ATP13A5

7.98e-0422562EFO_0011039
DiseaseSarcosine measurement

PCDHGA6 PCDHGA1

8.72e-0423562EFO_0021668
Diseasemental development measurement

PCDHGA6 PCDHGA1

1.03e-0325562EFO_0008230
Diseasecancer (implicated_via_orthology)

MTOR POLE ESRRG PROX1

1.69e-03268564DOID:162 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
DTGLSHYQGGPTLSM

ZNF280D

151

Q6N043
HTAGYEMSLNGSPRS

ABLIM3

556

O94929
YMHTGNSSTPRGEGG

ATP13A5

776

Q4VNC0
GANSGGPVMPSDYQH

CDK19

446

Q9BWU1
PSQGGSSLGMAQRHN

CSRNP2

86

Q9H175
YLGGHSSQPMENSGF

ACBD5

336

Q5T8D3
CGVSANTMDYGGHTP

ASB10

316

Q8WXI3
HRSPEYSTAMGAGGG

A2ML1

696

A8K2U0
GNTPLHYAAMGGFAD

ANKEF1

251

Q9NU02
NGHNGYPNGTSAALR

CSDE1

11

O75534
GPLMHSPYFSSSGNG

C1orf94

581

Q6P1W5
QASSSYMHGGNPSGS

HNRNPLL

321

Q8WVV9
QASGGGLASMPGSHF

PCDHGA6

726

Q9Y5G7
QFPHGAMGSYCNGGL

NKX2-4

101

Q9H2Z4
PGAGGYLNSMHSLVN

HOXA3

271

O43365
THLPHAASGAMDYGG

HOXA3

386

O43365
LGQSRMYFNASGPHH

MTMR10

711

Q9NXD2
MNSHSYNGSVGRPLG

KCNN1

1

Q92952
MGFVPHNGSLYGQAS

ADAMTSL2

361

Q86TH1
GGPANAGNMRYSHST

LCA5L

541

O95447
YSGHPEQYSAGMGRS

FOXC2

41

Q99958
MSYHSFQPGSRCGSQ

KRT82

1

Q9NSB4
NQMPSLGALYSAEHG

POLE

1521

Q07864
YNGAGGDTHRAMLPS

PGGHG

46

Q32M88
HATSDYGLQNPGMNR

PRICKLE1

736

Q96MT3
QGSNYGSPRPAHANM

CACNA1C

16

Q13936
NHTGGNIARFSPGMS

CR2

861

P20023
GSYSSTMNGHQNGLD

ESRRG

66

P62508
GFPSSNVHVYSNGRM

DNAJB12

211

Q9NXW2
SSQGGYGRNADHSMN

ILF3

876

Q12906
GNTSPMALGHGQARG

AKNA

156

Q7Z591
MNRGSQFAYGDHQSP

COL5A2

1366

P05997
MSGGSADYNREHGGP

EIF4A2

1

Q14240
QASGGGLASMPGSHF

PCDHGA1

726

Q9Y5H4
YSSHQGLMGFGTSPS

MTOR

336

P42345
MGGHLYPSTTSQGLA

NNT

546

Q13423
SHTLYPAFALMGSGG

TRIM36

696

Q9NQ86
YSGSAMQEGLSPNHL

PROX1

571

Q92786
NNNYGLNMSSPPHGS

NCOA3

456

Q9Y6Q9
GNMGHARSSNYSLPG

SIX1

236

Q15475
HGAGNGLRYGLSSMQ

PPM1B

16

O75688
SMYHRQGGVPGTFAN

RNF220

71

Q5VTB9
CGGSYPSMGHRANLA

PRR12

316

Q9ULL5
YMGLPGSGNTLHSDS

NPAP1

851

Q9NZP6
SGSSLSQAPSHMYGN

MLLT10

631

P55197
PSGGSQGPSHYMARY

CLDN6

186

P56747
MSSAHFNRGPAYGLS

CNN1

1

P51911
GYSHAGPASQGVPMQ

SS18L1

151

O75177
TNMPATFGHLAGGYD

NLN

616

Q9BYT8
GLSSAAGSCGYMPVH

RHBDD3

111

Q9Y3P4
MNRGGGSPSAAANYL

SESN3

1

P58005
MLPGHSQYSFTGGSQ

STOX1

751

Q6ZVD7
GGPNSCHFGKQYTSM

PRLR

81

P16471
GHTPYSSMLNQGLGV

SLC30A6

416

Q6NXT4
MHPTRYILAGGNSSG

WDR76

601

Q9H967
GTNMPATFGHLAGGY

THOP1

591

P52888
ELQTGPGSSQHYGAM

XIRP1

1751

Q702N8
DSMGNPRCDGHQQGY

TRPV4

846

Q9HBA0