Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	SLC16A9 SLC19A2 SLC7A9 SLC6A8 SLC22A16 SLC6A20	4.67e-08	33	123	6	GO:0072349
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC37A1 ANO10 SLC6A2 SLC6A8 CLCN3 CLCN4 CLCN5 SLC17A8 XPR1	1.14e-06	171	123	9	GO:0015103
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC37A1 SLC16A9 SLC7A9 SLC6A2 SLC6A8 CLCN3 CLCN4 CLCN5 SLC6A20 SLC17A8 XPR1	2.23e-06	296	123	11	GO:0015291
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC37A1 ATP6V1A SLC16A9 SLC7A9 SLC6A2 SLC6A8 ATP5MG CLCN3 CLCN4 CLCN5 SLC6A20 SLC17A8 XPR1	7.90e-06	477	123	13	GO:0022804
GeneOntologyMolecularFunction	transporter activity	SLC37A1 ATP6V1A SLC16A9 TRPC3 SLC19A2 ANO10 ASIC5 GRIN2D ATP9A SLC7A9 SLC6A2 SLC6A8 ATP5MG IGF1R CLCN3 CLCN4 PKD2L2 CLCN5 SLC22A16 SLC6A20 SLC17A8 XPR1	1.17e-05	1289	123	22	GO:0005215
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC16A9 SLC19A2 SLC6A2 SLC6A8 SLC22A16 SLC6A20	1.24e-05	83	123	6	GO:0015101
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	ANO10 SLC6A2 SLC6A8 CLCN3 CLCN4 CLCN5 SLC17A8	1.24e-05	125	123	7	GO:0015108
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC37A1 ATP6V1A TRPC3 ANO10 ASIC5 GRIN2D SLC6A2 SLC6A8 ATP5MG CLCN3 CLCN4 PKD2L2 CLCN5 SLC6A20 SLC17A8 XPR1	1.70e-05	758	123	16	GO:0015318
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC37A1 ATP6V1A SLC16A9 TRPC3 SLC19A2 ANO10 ASIC5 GRIN2D SLC7A9 SLC6A2 SLC6A8 ATP5MG CLCN3 CLCN4 PKD2L2 CLCN5 SLC22A16 SLC6A20 SLC17A8 XPR1	3.42e-05	1180	123	20	GO:0022857
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN3 CLCN4 CLCN5	3.63e-05	11	123	3	GO:0005247
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	ANO10 SLC6A2 SLC6A8 CLCN3 CLCN4 CLCN5 SLC17A8	4.20e-05	151	123	7	GO:0008509
GeneOntologyMolecularFunction	quaternary ammonium group transmembrane transporter activity	SLC16A9 SLC22A16 SLC6A20	9.83e-05	15	123	3	GO:0015651
GeneOntologyMolecularFunction	nucleoside triphosphate adenylate kinase activity	AK3 AK4	1.12e-04	3	123	2	GO:0046899
GeneOntologyMolecularFunction	monoatomic ion channel activity	ATP6V1A TRPC3 ANO10 ASIC5 GRIN2D ATP5MG CLCN3 CLCN4 PKD2L2 CLCN5 SLC17A8	1.28e-04	459	123	11	GO:0005216
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	CLCN3 CLCN4 CLCN5	1.46e-04	17	123	3	GO:0008308
GeneOntologyMolecularFunction	chloride channel activity	ANO10 CLCN3 CLCN4 CLCN5 SLC17A8	1.91e-04	86	123	5	GO:0005254
GeneOntologyMolecularFunction	creatine transmembrane transporter activity	SLC16A9 SLC6A8	2.24e-04	4	123	2	GO:0005308
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC16A9 SLC19A2 GRIN2D SLC7A9 SLC6A8 SLC6A20 SLC17A8	2.99e-04	207	123	7	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC16A9 SLC19A2 GRIN2D SLC7A9 SLC6A8 SLC6A20 SLC17A8	3.08e-04	208	123	7	GO:0005342
GeneOntologyMolecularFunction	alkylglycerophosphoethanolamine phosphodiesterase activity	GNA11 GNAQ	3.72e-04	5	123	2	GO:0047391
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ATP6V1A TRPC3 ANO10 ASIC5 GRIN2D SLC6A2 SLC6A8 ATP5MG CLCN3 CLCN4 PKD2L2 CLCN5 SLC6A20 SLC17A8	3.79e-04	793	123	14	GO:0015075
GeneOntologyMolecularFunction	channel activity	ATP6V1A TRPC3 ANO10 ASIC5 GRIN2D ATP5MG CLCN3 CLCN4 PKD2L2 CLCN5 SLC17A8	4.06e-04	525	123	11	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	ATP6V1A TRPC3 ANO10 ASIC5 GRIN2D ATP5MG CLCN3 CLCN4 PKD2L2 CLCN5 SLC17A8	4.13e-04	526	123	11	GO:0022803
GeneOntologyMolecularFunction	phosphate transmembrane transporter activity	SLC37A1 SLC17A8 XPR1	4.20e-04	24	123	3	GO:0005315
GeneOntologyMolecularFunction	monoatomic anion channel activity	ANO10 CLCN3 CLCN4 CLCN5 SLC17A8	4.42e-04	103	123	5	GO:0005253
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC37A1 SLC16A9 SLC19A2 GRIN2D SLC7A9 SLC6A8 SLC6A20 SLC17A8	4.68e-04	293	123	8	GO:0008514
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	GRIN2D SLC7A9 SLC6A8 SLC6A20 SLC17A8	4.83e-04	105	123	5	GO:0015171
GeneOntologyMolecularFunction	carnitine transmembrane transporter activity	SLC16A9 SLC22A16	5.55e-04	6	123	2	GO:0015226
GeneOntologyMolecularFunction	proton channel activity	ATP6V1A ASIC5 ATP5MG	5.99e-04	27	123	3	GO:0015252
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activity	CDK17 CDK13 CDK11B	8.20e-04	30	123	3	GO:0004693
GeneOntologyMolecularFunction	cyclin-dependent protein kinase activity	CDK17 CDK13 CDK11B	8.20e-04	30	123	3	GO:0097472
GeneOntologyMolecularFunction	sphingolipid binding	SELL CEL LAPTM4B	1.19e-03	34	123	3	GO:0046625
GeneOntologyMolecularFunction	receptor serine/threonine kinase binding	CAV1 NEO1 SMAD7	1.29e-03	35	123	3	GO:0033612
GeneOntologyMolecularFunction	adenylate kinase activity	AK3 AK4	1.32e-03	9	123	2	GO:0004017
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC6A2 SLC6A8 SLC6A20 SLC17A8	1.58e-03	81	123	4	GO:0015370
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	LPAR3 OR9G1 OR4K13 OR9G4 MFSD6 GPR87 GRIN2D OR9G9 IGF1R OR1I1 OR1Q1 NID1 RXFP4 P2RY14 ROS1 TAS2R41 GPR45 OR10A5	1.58e-03	1353	123	18	GO:0004888
GeneOntologyMolecularFunction	antiporter activity	SLC37A1 SLC7A9 CLCN3 CLCN4 CLCN5	1.65e-03	138	123	5	GO:0015297
GeneOntologyMolecularFunction	symporter activity	SLC16A9 SLC6A2 SLC6A8 SLC6A20 SLC17A8	2.38e-03	150	123	5	GO:0015293
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	ATP6V1A TRPC3 ANO10 ASIC5 GRIN2D SLC6A2 SLC6A8 ATP5MG PKD2L2 SLC6A20 SLC17A8	2.69e-03	664	123	11	GO:0008324
GeneOntologyMolecularFunction	glycosphingolipid binding	SELL CEL	2.81e-03	13	123	2	GO:0043208
GeneOntologyMolecularFunction	G protein-coupled purinergic nucleotide receptor activity	GPR87 P2RY14	2.81e-03	13	123	2	GO:0045028
GeneOntologyMolecularFunction	G protein-coupled receptor activity	LPAR3 OR9G1 OR4K13 OR9G4 GPR87 OR9G9 OR1I1 OR1Q1 RXFP4 P2RY14 TAS2R41 GPR45 OR10A5	3.16e-03	884	123	13	GO:0004930
GeneOntologyMolecularFunction	alcohol binding	TRPC3 CAV1 SCAP XPR1	3.66e-03	102	123	4	GO:0043178
GeneOntologyBiologicalProcess	modified amino acid transport	SLC16A9 SLC19A2 SLC7A9 SLC6A8 SLC22A16 SLC6A20	2.69e-07	44	126	6	GO:0072337
GeneOntologyBiologicalProcess	inorganic anion transport	SLC37A1 ANO10 CLCN3 CLCN4 CLCN5 SLC17A8 ROS1 XPR1	1.51e-05	180	126	8	GO:0015698
GeneOntologyBiologicalProcess	inorganic anion transmembrane transport	SLC37A1 ANO10 CLCN3 CLCN4 CLCN5 SLC17A8 XPR1	1.85e-05	134	126	7	GO:0098661
GeneOntologyBiologicalProcess	organic cation transport	SLC16A9 SLC19A2 SLC6A2 SLC35F3 SLC22A16 SLC6A20 SLC17A8	3.08e-05	145	126	7	GO:0015695
GeneOntologyBiologicalProcess	phosphate ion transport	SLC37A1 SLC17A8 ROS1 XPR1	3.68e-05	31	126	4	GO:0006817
GeneOntologyBiologicalProcess	amino-acid betaine transport	SLC16A9 SLC22A16 SLC6A20	7.71e-05	14	126	3	GO:0015838
GeneOntologyBiologicalProcess	detection of stimulus	OR9G1 OR4K13 OR9G4 TRPC3 GRIN2D OR9G9 PKD2L2 OR1I1 OR1Q1 PTPRQ GNA11 TAS2R41 GNAQ OR10A5	1.35e-04	722	126	14	GO:0051606
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC37A1 ATP6V1A TRPC3 ANO10 CAV1 ASIC5 GRIN2D SLC6A2 SLC6A8 ATP5MG CLCN3 CLCN4 PKD2L2 CLCN5 SLC6A20 SLC17A8 XPR1	1.53e-04	1017	126	17	GO:0098660
Domain	Cl-channel_core	CLCN3 CLCN4 CLCN5	2.22e-05	9	122	3	IPR014743
Domain	-	CLCN3 CLCN4 CLCN5	2.22e-05	9	122	3	1.10.3080.10
Domain	Voltage_CLC	CLCN3 CLCN4 CLCN5	2.22e-05	9	122	3	PF00654
Domain	Cl-channel_volt-gated	CLCN3 CLCN4 CLCN5	2.22e-05	9	122	3	IPR001807
Domain	AK3/Ak4_mitochondrial	AK3 AK4	4.23e-05	2	122	2	IPR028586
Domain	Adenyl_kin_sub	AK3 AK4	1.26e-04	3	122	2	IPR006259
Domain	ADK_lid	AK3 AK4	1.26e-04	3	122	2	PF05191
Domain	P2Y13_rcpt	GPR87 P2RY14	1.26e-04	3	122	2	IPR008109
Domain	CBS	CLCN3 CLCN4 CLCN5	1.43e-04	16	122	3	SM00116
Domain	NA_NEUROTRAN_SYMP_2	SLC6A2 SLC6A8 SLC6A20	2.07e-04	18	122	3	PS00754
Domain	SNF	SLC6A2 SLC6A8 SLC6A20	2.44e-04	19	122	3	PF00209
Domain	Na/ntran_symport	SLC6A2 SLC6A8 SLC6A20	2.44e-04	19	122	3	IPR000175
Domain	NA_NEUROTRAN_SYMP_1	SLC6A2 SLC6A8 SLC6A20	2.44e-04	19	122	3	PS00610
Domain	NA_NEUROTRAN_SYMP_3	SLC6A2 SLC6A8 SLC6A20	2.44e-04	19	122	3	PS50267
Domain	MFS_dom	SLC37A1 SLC16A9 MFSD6 SLC19A2 SLC22A16 SLC17A8	2.49e-04	134	122	6	IPR020846
Domain	Adenylate_kinase_lid-dom	AK3 AK4	2.52e-04	4	122	2	IPR007862
Domain	Gprotein_alpha_Q	GNA11 GNAQ	2.52e-04	4	122	2	IPR000654
Domain	CBS_dom	CLCN3 CLCN4 CLCN5	2.86e-04	20	122	3	IPR000644
Domain	CBS	CLCN3 CLCN4 CLCN5	2.86e-04	20	122	3	PF00571
Domain	CBS	CLCN3 CLCN4 CLCN5	2.86e-04	20	122	3	PS51371
Domain	Adenylat_kinase_CS	AK3 AK4	6.24e-04	6	122	2	IPR033690
Domain	MFS	SLC37A1 SLC16A9 MFSD6 SLC22A16 SLC17A8	7.14e-04	108	122	5	PS50850
Domain	ADENYLATE_KINASE	AK3 AK4	1.15e-03	8	122	2	PS00113
Domain	Tektin	TEKT3 TEKT5	1.15e-03	8	122	2	IPR000435
Domain	GPCR_Rhodpsn_7TM	LPAR3 OR9G1 OR4K13 OR9G4 GPR87 OR9G9 OR1I1 OR1Q1 RXFP4 P2RY14 GPR45 OR10A5	1.46e-03	670	122	12	IPR017452
Domain	7tm_1	LPAR3 OR9G1 OR4K13 OR9G4 GPR87 OR9G9 OR1I1 OR1Q1 RXFP4 P2RY14 GPR45 OR10A5	1.60e-03	677	122	12	PF00001
Domain	MFS_1	SLC37A1 SLC16A9 MFSD6 SLC17A8	1.62e-03	77	122	4	PF07690
Domain	MFS	SLC37A1 SLC16A9 MFSD6 SLC17A8	1.62e-03	77	122	4	IPR011701
Domain	G_PROTEIN_RECEP_F1_1	LPAR3 OR9G1 OR4K13 OR9G4 GPR87 OR9G9 OR1I1 OR1Q1 RXFP4 P2RY14 GPR45 OR10A5	1.76e-03	685	122	12	PS00237
Domain	Adenylat/UMP-CMP_kin	AK3 AK4	1.84e-03	10	122	2	IPR000850
Domain	G_PROTEIN_RECEP_F1_2	LPAR3 OR9G1 OR4K13 OR9G4 GPR87 OR9G9 OR1I1 OR1Q1 RXFP4 P2RY14 GPR45 OR10A5	1.89e-03	691	122	12	PS50262
Domain	GPCR_Rhodpsn	LPAR3 OR9G1 OR4K13 OR9G4 GPR87 OR9G9 OR1I1 OR1Q1 RXFP4 P2RY14 GPR45 OR10A5	1.92e-03	692	122	12	IPR000276
Domain	-	PON3 NID1 ROS1	2.09e-03	39	122	3	2.120.10.30
Domain	Tyr_kinase_rcpt_2_CS	IGF1R ROS1	2.24e-03	11	122	2	IPR002011
Domain	RECEPTOR_TYR_KIN_II	IGF1R ROS1	2.68e-03	12	122	2	PS00239
Domain	-	LSS C5	2.68e-03	12	122	2	1.50.10.20
Domain	Carboxylesterase_B_CS	CEL NLGN2	3.15e-03	13	122	2	IPR019819
Domain	6-blade_b-propeller_TolB-like	PON3 NID1 ROS1	3.36e-03	46	122	3	IPR011042
Domain	CARBOXYLESTERASE_B_2	CEL NLGN2	3.66e-03	14	122	2	PS00941
Domain	COesterase	CEL NLGN2	3.66e-03	14	122	2	PF00135
Domain	CarbesteraseB	CEL NLGN2	3.66e-03	14	122	2	IPR002018
Domain	LY	NID1 ROS1	4.20e-03	15	122	2	SM00135
Domain	LDLR_classB_rpt	NID1 ROS1	4.20e-03	15	122	2	IPR000033
Domain	GproteinA_insert	GNA11 GNAQ	4.78e-03	16	122	2	IPR011025
Domain	-	GNA11 GNAQ	4.78e-03	16	122	2	1.10.400.10
Domain	G-alpha	GNA11 GNAQ	4.78e-03	16	122	2	PF00503
Domain	G_alpha	GNA11 GNAQ	4.78e-03	16	122	2	SM00275
Domain	Gprotein_alpha_su	GNA11 GNAQ	5.40e-03	17	122	2	IPR001019
Domain	Terpenoid_cyclase/PrenylTrfase	LSS C5	6.05e-03	18	122	2	IPR008930
Domain	HATPase_c	MORC1 HSP90B1	6.05e-03	18	122	2	SM00387
Pathway	KEGG_MEDICUS_REFERENCE_LPA_GNAQ_11_RHOA_SIGNALING_PATHWAY	LPAR3 GNA11 GNAQ	2.27e-05	9	93	3	M47732
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ATP6V1A TRPC3 ANO10 ASIC5 ATP9A CLCN3 CLCN4 CLCN5	2.75e-05	183	93	8	M997
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	ACSL4 GNA11 GNAQ	4.41e-05	11	93	3	M27317
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	ACSL4 GNA11 GNAQ	4.41e-05	11	93	3	MM15035
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TRPC3 ANO10 ASIC5 CLCN3 CLCN4 CLCN5	7.03e-05	106	93	6	M27200
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ATP6V1A TRPC3 ANO10 ASIC5 ATP9A CLCN4 CLCN5	1.61e-04	176	93	7	MM15718
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	LPAR3 RGSL1 RGS11 RXFP4 P2RY14 GNA11 TAS2R41 C5 GNAQ	2.24e-04	314	93	9	M600
Pathway	WP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA	TRPC3 GNA11 GNAQ	3.91e-04	22	93	3	M39795
Pubmed	Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice.	AMELX CLCN4 CLCN5	1.94e-07	4	128	3	7670496
Pubmed	Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation.	CLCN3 CLCN4 CLCN5	1.94e-07	4	128	3	20351103
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TMEM248 SELENBP1 PIGS SLC19A2 CPD CAV1 CLDN1 ELOVL7 IARS2 NEO1 SCAP RNPEP DPY19L4 AK4 LSS C5 GNAQ	3.87e-07	1061	128	17	33845483
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	WWOX VPS13C PIGS CPD CAV1 ATP9A ACSL4 NBAS NEO1 SCAP TYW1B MIGA1	3.91e-07	504	128	12	34432599
Pubmed	An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.	CLCN3 CLCN4 CLCN5	4.84e-07	5	128	3	19339555
Pubmed	Expression of CLCN voltage-gated chloride channel genes in human blood vessels.	CLCN3 CLCN4 CLCN5	9.66e-07	6	128	3	10198195
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCN3 CLCN4 CLCN5	4.02e-06	9	128	3	23115349
Pubmed	Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling.	ATP6V1A CPD CAV1 LSS GNAQ	8.20e-06	74	128	5	17255364
Pubmed	Cyclin-dependent kinases: a family portrait.	CDK17 CDK13 CDK11B	1.05e-05	12	128	3	19884882
Pubmed	The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan.	GNA11 GNAQ	1.34e-05	2	128	2	28248732
Pubmed	Activation of Gq/11 in the mouse corpus luteum is required for parturition.	GNA11 GNAQ	1.34e-05	2	128	2	25495873
Pubmed	Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer.	MTHFR FTO	1.34e-05	2	128	2	24023349
Pubmed	Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix.	AK3 AK4	1.34e-05	2	128	2	11485571
Pubmed	Identification and functional characterization of a voltage-gated chloride channel and its novel splice variant in taste bud cells.	CLCN4 CLCN5	1.34e-05	2	128	2	16129671
Pubmed	Molecular genetic testing of uveal melanoma from routinely processed and stained cytology specimens.	GNA11 GNAQ	1.34e-05	2	128	2	21945171
Pubmed	Preferential association with ClC-3 permits sorting of ClC-4 into endosomal compartments.	CLCN3 CLCN4	1.34e-05	2	128	2	28972156
Pubmed	Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.	GNA11 GNAQ	1.34e-05	2	128	2	9175863
Pubmed	The ethnic profile of patients with birthmarks reveals interaction of germline and postzygotic genetics.	GNA11 GNAQ	1.34e-05	2	128	2	28083870
Pubmed	Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation.	GNA11 GNAQ	1.34e-05	2	128	2	26843449
Pubmed	Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.	GNA11 GNAQ	1.34e-05	2	128	2	30890659
Pubmed	Abrogated Caveolin-1 expression via histone modification enzyme Setdb2 regulates brain edema in a mouse model of influenza-associated encephalopathy.	CAV1 SETDB2	1.34e-05	2	128	2	30670717
Pubmed	Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqalpha and G11alpha knockout mice.	GNA11 GNAQ	1.34e-05	2	128	2	9607776
Pubmed	Reverse Phenotyping in Patients with Skin Capillary Malformations and Mosaic GNAQ or GNA11 Mutations Defines a Clinical Spectrum with Genotype-Phenotype Correlation.	GNA11 GNAQ	1.34e-05	2	128	2	31726051
Pubmed	G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region.	GNA11 GNAQ	1.34e-05	2	128	2	11438569
Pubmed	GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification.	GNA11 GNAQ	1.34e-05	2	128	2	37802294
Pubmed	Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.	GNA11 GNAQ	1.34e-05	2	128	2	26628681
Pubmed	The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresis.	GNA11 GNAQ	1.34e-05	2	128	2	17552882
Pubmed	Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations.	GNA11 GNAQ	1.34e-05	2	128	2	31173078
Pubmed	Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.	GNA11 GNAQ	1.34e-05	2	128	2	29209985
Pubmed	Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior.	GNA11 GNAQ	1.34e-05	2	128	2	15175381
Pubmed	Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.	CLCN4 CLCN5	1.34e-05	2	128	2	16034421
Pubmed	Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese.	GNA11 GNAQ	1.34e-05	2	128	2	25280020
Pubmed	GNAQ and GNA11 mutations occur in 9.5% of mucosal melanoma and are associated with poor prognosis.	GNA11 GNAQ	1.34e-05	2	128	2	27498141
Pubmed	Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.	CLCN3 CLCN4	1.34e-05	2	128	2	32118314
Pubmed	Uveal Melanoma: GNAQ and GNA11 Mutations in a Greek Population.	GNA11 GNAQ	1.34e-05	2	128	2	28982892
Pubmed	Mutations in GNA11 in uveal melanoma.	GNA11 GNAQ	1.34e-05	2	128	2	21083380
Pubmed	Effect of MTHFR (rs1801133) and FTO (rs9939609) genetic polymorphisms and obesity in T2DM: a study among Bengalee Hindu caste population of West Bengal, India.	MTHFR FTO	1.34e-05	2	128	2	33455465
Pubmed	GNAQ and GNA11 mutations in uveal melanoma.	GNA11 GNAQ	1.34e-05	2	128	2	25304237
Pubmed	Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.	GNA11 GNAQ	1.34e-05	2	128	2	28301547
Pubmed	Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation.	GNA11 GNAQ	1.34e-05	2	128	2	16847339
Pubmed	Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.	GNA11 GNAQ	1.34e-05	2	128	2	29570931
Pubmed	Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice.	GNA11 GNAQ	1.34e-05	2	128	2	10818132
Pubmed	Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.	GNA11 GNAQ	1.34e-05	2	128	2	26272756
Pubmed	NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathway.	GNA11 GNAQ	1.34e-05	2	128	2	31461351
Pubmed	Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma.	GNA11 GNAQ	1.34e-05	2	128	2	23634288
Pubmed	Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.	GNA11 GNAQ	1.34e-05	2	128	2	26368812
Pubmed	Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current.	GNA11 GNAQ	1.34e-05	2	128	2	17482476
Pubmed	Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.	GNA11 GNAQ	1.34e-05	2	128	2	24141786
Pubmed	Chloride/proton antiporters ClC3 and ClC5 support bone formation in mice.	CLCN3 CLCN5	1.34e-05	2	128	2	38666049
Pubmed	Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.	GNA11 GNAQ	1.34e-05	2	128	2	37102682
Pubmed	Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.	GNA11 GNAQ	1.34e-05	2	128	2	7492305
Pubmed	[Assessment of the sufficiency of Moscow population with folic acid, depending on the combined effect of polymorphism of MTHFR and FTO genes].	MTHFR FTO	1.34e-05	2	128	2	30592864
Pubmed	Reduced trabecular bone mass and strength in mice overexpressing Gα11 protein in cells of the osteoblast lineage.	GNA11 GNAQ	1.34e-05	2	128	2	24308950
Pubmed	Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes.	GNA11 GNAQ	1.34e-05	2	128	2	22562663
Pubmed	Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.	GNA11 GNAQ	1.34e-05	2	128	2	11826096
Pubmed	Blue nevi and variants: an update.	GNA11 GNAQ	1.34e-05	2	128	2	21366456
Pubmed	In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations.	GNA11 GNAQ	1.34e-05	2	128	2	35580369
Pubmed	Evidence for the assignment of the loci AK1, AK3 and ACONs to chromosome 9 in man.	AK3 AK4	1.34e-05	2	128	2	182062
Pubmed	Papillary Hemangioma Harbors Somatic GNA11 and GNAQ Mutations.	GNA11 GNAQ	1.34e-05	2	128	2	37750536
Pubmed	Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.	GNA11 GNAQ	1.34e-05	2	128	2	26778290
Pubmed	Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.	GNA11 GNAQ	1.34e-05	2	128	2	30936140
Pubmed	Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11.	GNA11 GNAQ	1.34e-05	2	128	2	23778528
Pubmed	High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.	GNA11 GNAQ	1.34e-05	2	128	2	22977135
Pubmed	An experimental strategy to probe Gq contribution to signal transduction in living cells.	GNA11 GNAQ	1.34e-05	2	128	2	33639168
Pubmed	Genetic implication of a novel thiamine transporter in human hypertension.	SLC19A2 SLC35F3	1.34e-05	2	128	2	24509276
Pubmed	GNAQ and GNA11 mutant nonuveal melanoma: a subtype distinct from both cutaneous and uveal melanoma.	GNA11 GNAQ	1.34e-05	2	128	2	32064597
Pubmed	The m6A eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation.	ACSL4 FTO	1.34e-05	2	128	2	39004378
Pubmed	Mutational analysis of GNAQ and GNA11 to aid therapy management of a choroidal melanoma metastatic to the contralateral orbit.	GNA11 GNAQ	1.34e-05	2	128	2	23572068
Pubmed	Low mutational burden of eight genes involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 pathways in female genital tract primary melanomas.	GNA11 GNAQ	1.34e-05	2	128	2	25695059
Pubmed	Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1.	GNA11 GNAQ	1.34e-05	2	128	2	12351712
Pubmed	Cardiac remodeling in Gαq and Gα11 knockout mice.	GNA11 GNAQ	1.34e-05	2	128	2	26476043
Pubmed	N6-methyladenosine demethylase FTO promotes growth and metastasis of gastric cancer via m6A modification of caveolin-1 and metabolic regulation of mitochondrial dynamics.	CAV1 FTO	1.34e-05	2	128	2	35064107
Pubmed	Early-onset hypertension associated with extensive cutaneous capillary malformations harboring postzygotic variants in GNAQ and GNA11.	GNA11 GNAQ	1.34e-05	2	128	2	36440997
Pubmed	Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice.	GNA11 GNAQ	1.34e-05	2	128	2	15713647
Pubmed	GNAQ and GNA11 mutations in melanocytomas of the central nervous system.	GNA11 GNAQ	1.34e-05	2	128	2	22307269
Pubmed	Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice.	CAV1 CLDN1 NID1	2.63e-05	16	128	3	11564885
Pubmed	Defining the membrane proteome of NK cells.	SLC37A1 HSP90B1 PIGS MFSD6 CPD ANO10 ACSL4 NBAS PARP4 EEF1G CLCN3 CLCN5 GSTK1 LSS DAAM1	2.72e-05	1168	128	15	19946888
Pubmed	Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1.	GNA11 GNAQ	4.02e-05	3	128	2	33003441
Pubmed	P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.	GNA11 GNAQ	4.02e-05	3	128	2	26168216
Pubmed	Evidence of evolutionary up-regulation of the single active X chromosome in mammals based on Clc4 expression levels in Mus spretus and Mus musculus.	CLCN4 CLCN5	4.02e-05	3	128	2	9256467
Pubmed	Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.	GNA11 GNAQ	4.02e-05	3	128	2	8836152
Pubmed	Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes.	GNA11 GNAQ	4.02e-05	3	128	2	20372981
Pubmed	The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects.	GNA11 GNAQ	4.02e-05	3	128	2	32576659
Pubmed	Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development.	GNA11 GNAQ	4.02e-05	3	128	2	17694176
Pubmed	Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.	GNA11 GNAQ	4.02e-05	3	128	2	21464134
Pubmed	G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.	GNA11 GNAQ	4.02e-05	3	128	2	2123549
Pubmed	CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.	GNA11 GNAQ	4.02e-05	3	128	2	30552676
Pubmed	IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells.	CAV1 IGF1R	4.02e-05	3	128	2	21152401
Pubmed	G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone.	GNA11 GNAQ	4.02e-05	3	128	2	21345793
Pubmed	Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice.	GNA11 GNAQ	4.02e-05	3	128	2	10629036
Pubmed	Caveolin-1 increases glycolysis in pancreatic cancer cells and triggers cachectic states.	CAV1 IGF1R	4.02e-05	3	128	2	34320244
Pubmed	Cloning and functional characterization of the promoter region of the gene encoding human adenylate kinase isozyme 3.	AK3 AK4	4.02e-05	3	128	2	10544043
Pubmed	High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms.	GNA11 GNAQ	4.02e-05	3	128	2	31189994
Pubmed	Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling.	GNA11 GNAQ	4.02e-05	3	128	2	12670961
Pubmed	IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis.	CAV1 IGF1R	4.02e-05	3	128	2	21611203
Pubmed	Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse.	GNA11 GNAQ	4.02e-05	3	128	2	31091422
Pubmed	G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins.	GNA11 GNAQ	4.02e-05	3	128	2	26595811
Pubmed	Support of bone mineral deposition by regulation of pH.	CLCN3 CLCN5	4.02e-05	3	128	2	30044661
Pubmed	Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.	GNA11 GNAQ	4.02e-05	3	128	2	28700778
Pubmed	The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.	GNA11 GNAQ	4.02e-05	3	128	2	10446129
Interaction	TTYH1 interactions	LPAR3 WWOX PCNX3 PIGS ANO10 ACSL4 SCAP FAR2 DPY19L4 PIGW XPR1	1.42e-06	300	117	11	int:TTYH1
Interaction	RAB7A interactions	ATP6V1A HSP90B1 WWOX VPS13C PIGS CPD CAV1 ATP9A AK3 ACSL4 ATP5MG NBAS NEO1 SCAP CLCN5 TYW1B MIGA1 XPR1	3.48e-06	886	117	18	int:RAB7A
Interaction	TSPAN15 interactions	PCNX3 PIGS SLC19A2 ATP9A SCAP FAR2 SLC22A16 DPY19L4 PIGW GNA11	4.85e-06	276	117	10	int:TSPAN15
Cytoband	8q22.1	LAPTM4B DPY19L4 NDUFAF6	1.94e-04	40	128	3	8q22.1
GeneFamily	Chloride voltage-gated channels	CLCN3 CLCN4 CLCN5	1.26e-05	10	87	3	302
GeneFamily	Solute carriers	SLC37A1 SLC16A9 SLC19A2 SLC7A9 SLC6A2 SLC6A8 SLC35F3 SLC22A16 SLC6A20 SLC17A8	1.98e-05	395	87	10	752
GeneFamily	Olfactory receptors, family 9	OR9G1 OR9G4 OR9G9	1.78e-04	23	87	3	156
GeneFamily	Tektins	TEKT3 TEKT5	2.27e-04	5	87	2	949
GeneFamily	Cyclin dependent kinases	CDK17 CDK13 CDK11B	2.58e-04	26	87	3	496
GeneFamily	Adenylate kinases	AK3 AK4	8.06e-04	9	87	2	356
Coexpression	FAN_EMBRYONIC_CTX_OLIG	UBR1 CDK17 MFSD6 KCTD8 CPD ANO10 ELOVL7 FRY NEO1 CLCN3 CLCN4 DNAH17 PCSK7 MIGA1 SMAD7	3.21e-06	754	125	15	M39037
Coexpression	RAF_UP.V1_DN	SELENBP1 RHOBTB3 SLC19A2 CAV1 IGF1R AK4 FTO SMAD7	4.21e-06	193	125	8	M2726
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	TMEM248 PCNX3 TOR2A PIGS LAPTM4B SLC19A2 CPD ANO10 NEO1 IGF1R TYW1B NID1 NLGN2	2.33e-05	681	125	13	M5314
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	TMEM248 PCNX3 TOR2A PIGS LAPTM4B SLC19A2 CPD ANO10 NEO1 IGF1R TYW1B NID1 NLGN2	3.24e-05	703	125	13	MM1055
ToppCell	Ionocyte-iono-2\|World / Class top	ATP6V1A CEL TEKT5 MBOAT2 ELOVL7 SLC6A2 P2RY14	6.67e-07	173	127	7	e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	ARHGAP42 KANSL1L SLC16A9 CDHR3 AGBL3 AGMO AK4	1.01e-06	184	127	7	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	ARHGAP42 LPAR3 SWAP70 TRPC3 FRMD1 NID1 P2RY14	1.76e-06	200	127	7	69edc375d85689300d1dbc1217fedc40063ecdcb
ToppCell	Ionocyte\|World / Class top	ATP6V1A CEL TEKT5 ELOVL7 SLC6A2 P2RY14	9.44e-06	170	127	6	d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCell	Severe-B_naive-11\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SELL VPS13C CLCN4 CDK13 P2RY14 CPLANE1	9.76e-06	171	127	6	7c2699f19ca38414447a286f7658f507882d57c2
ToppCell	ASK428-Immune-B_cell\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	SELL ATP9A CLCN3 CLCN5 GSTK1 P2RY14	1.08e-05	174	127	6	b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 FRMD1 SLC7A9 AGMO AK4	1.27e-05	179	127	6	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP42 TRPC3 RGS11 AGMO NID1 P2RY14	1.27e-05	179	127	6	dc6cd46fa652b296ddbc41855f6377946d0a4cdc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO SLC6A20 AK4	1.39e-05	182	127	6	e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO SLC6A20 AK4	1.39e-05	182	127	6	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO SLC6A20 AK4	1.39e-05	182	127	6	57bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO SLC6A20 AK4	1.57e-05	186	127	6	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PON3 MYO5C FRY PTPRQ ROS1 C5	1.77e-05	190	127	6	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SELENBP1 PON3 ACSL4 SLC6A20 LSS ROS1	2.05e-05	195	127	6	37aa6e4123d37de4de42ca68d3020f2a7686ce02
ToppCell	NS-moderate-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SELENBP1 SLC16A9 LAPTM4B MBOAT2 CLDN1 MYO5C	2.11e-05	196	127	6	47930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CEL RHOBTB3 AK3 ACSL4 SLC6A8 CLCN5	2.24e-05	198	127	6	688b0eb5534dde40b8630ab8a3252c816711e02e
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SELL SELENBP1 LAPTM4B FRY GSTK1 SLC35F3	2.24e-05	198	127	6	e2aa1a2e5b188997e09686608cf0df55e61bd8b6
ToppCell	Bronchial-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP42 OR4K13 TRPC3 RGS11 NID1 P2RY14	2.37e-05	200	127	6	12326cc6f0af24bacba9493dc79e7c7347db2f41
ToppCell	PND28-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFAP47 LPAR3 RGSL1 SELENBP1 SLC35F3	6.01e-05	145	127	5	9b69bfdbf91ef197b4c483617aa67498d9d2cd79
ToppCell	PND28-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFAP47 LPAR3 RGSL1 SELENBP1 SLC35F3	6.01e-05	145	127	5	31af9fce1dcd7e8ae1604476598e099232017ee9
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGSL1 ASIC5 SLC7A9 PTPRQ ROS1	6.01e-05	145	127	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	PND28-Epithelial-Epithelial_Airway-Neurosecretory\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFAP47 LPAR3 RGSL1 SELENBP1 SLC35F3	6.01e-05	145	127	5	76f0cde9acdc3ad5948c007dccf312665972c9e6
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC37A1 CFAP47 MYO5C ACSL4 C5	8.25e-05	155	127	5	be575a0096415705dba425002247289ff8f89474
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MORC1 KCTD19 CPD MBOAT2 NID1	8.25e-05	155	127	5	8fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3\|TCGA-Skin / Sample_Type by Project: Shred V9	ARHGAP42 LAPTM4B IL17D FAR2 CLCN5	9.30e-05	159	127	5	fb222c42f66901852b01cec073ec0732245ee973
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	SLC37A1 SLC7A9 FAR2 RNPEP RNFT2	9.58e-05	160	127	5	ac3f56f8ab8efd11c4b4868a828db05c23ac762f
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RGSL1 ASIC5 SLC7A9 PTPRQ ROS1	1.02e-04	162	127	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	CLDN1 SLC7A9 PKD2L2 RNFT2 NID1	1.11e-04	165	127	5	3d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR87 CAV1 CLDN1 PTPRQ XPR1	1.14e-04	166	127	5	1f39c7507ac6881aa1a30f8be22f98a1837d926b
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC37A1 TMEM248 NBAS PKD2L2 SLC35F3	1.14e-04	166	127	5	139bf49eb3624d9eec7e8a2cb33d69716d63a7c5
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-plasma_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC37A1 TMEM248 NBAS PKD2L2 SLC35F3	1.14e-04	166	127	5	85f59c3cc7db8863ec0044f1fcc14580834f830b
ToppCell	droplet-Thymus-nan-3m-Myeloid-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SWAP70 RGS11 CPD TASL NID1	1.14e-04	166	127	5	c0af93db981dfd448abc7efcd257f3e5ff066aae
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 TEKT3 CDHR3 FTO CPLANE1	1.24e-04	169	127	5	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	Ionocyte-iono-1\|World / Class top	ATP6V1A CEL TEKT5 ELOVL7 P2RY14	1.24e-04	169	127	5	4b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MORC1 SELL TASL SLC35F3 P2RY14	1.27e-04	170	127	5	92e765ae0d3adb38d3b22fddb873fd5ccad3fd44
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MORC1 SELL TASL SLC35F3 P2RY14	1.27e-04	170	127	5	9f8b215caa1afa3cd7104c06fca7cfd790640f66
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLC37A1 SLC7A9 PKD2L2 RNFT2 NID1	1.31e-04	171	127	5	e59afa0a773dca3b9c208d17510ea55703b42598
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENBP1 CEL SLC19A2 RGS11 MYO5C	1.46e-04	175	127	5	3f1b2e23fec953148fb0711e523c463adb07dca4
ToppCell	PBMC-Convalescent\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	EGLN2 RGSL1 AK3 ATP5MG EEF1G	1.46e-04	175	127	5	d3f897271b64872535213a3dc27b9330255ef9ee
ToppCell	ASK428-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	SELL PON3 ATP9A CLCN3 CLCN5	1.46e-04	175	127	5	e0979e5795a49b4e5c9b88e7fe6b7bda7a413a6c
ToppCell	COVID-19_Convalescent\|World / Disease group, lineage and cell class	EGLN2 RGSL1 AK3 ATP5MG EEF1G	1.46e-04	175	127	5	4d6343308ec5a644af1432ef0f63dcaf9f02e4bc
ToppCell	PBMC-Convalescent\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EGLN2 RGSL1 AK3 ATP5MG EEF1G	1.46e-04	175	127	5	4dc4d0d3bf887a52adbe9d81c8a03fc95bc7a4b0
ToppCell	B_cells-pDCs\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	KCTD19 CLCN5 SLC35F3 P2RY14 GNAQ	1.50e-04	176	127	5	ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	LPAR3 KCTD19 CLCN5 SLC35F3 GNAQ	1.50e-04	176	127	5	d6e660df92a3d7dd5732171ee623763faf108476
ToppCell	IIH-CD8-antiviral_CD4\|IIH / Condition, Cell_class and T cell subcluster	SLC37A1 KANSL1L CDK17 SCAP OR1I1	1.54e-04	177	127	5	fe73608c40701eca88b260aeb5c0640d7bee72ba
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 SLC16A9 SLC35F3 AGMO AK4	1.62e-04	179	127	5	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	facs-Pancreas-Exocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENBP1 CEL SLC19A2 RGS11 MYO5C	1.62e-04	179	127	5	bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCell	facs-GAT-Fat-3m-Epithelial-epithelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 CDHR3 TEKT5 SLC7A9 SLC35F3	1.70e-04	181	127	5	e97cbaafb93fdbee8e3cf4a06e6bcf121d941403
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO AK4	1.70e-04	181	127	5	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	wk_20-22-Hematologic-Myeloid-pDC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SELL KCTD19 CLCN5 SLC35F3 P2RY14	1.70e-04	181	127	5	60607c5ff6d5b1cb416adc034491dca31c41e988
ToppCell	facs-GAT-Fat-3m-Epithelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 CDHR3 TEKT5 SLC7A9 SLC35F3	1.70e-04	181	127	5	11cb84528f7ca084f0a92eda4f2e18e63a428fe9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO AK4	1.70e-04	181	127	5	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	facs-GAT-Fat-3m-Epithelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 CDHR3 TEKT5 SLC7A9 SLC35F3	1.70e-04	181	127	5	5ffeca29e4d31a20c110d27af128ed024a79ad56
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-Treg\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELL TRAV10 MFSD6 MYO5C CDK11B	1.70e-04	181	127	5	3754970d62eea1d2522b11d977eea4362f90d21e
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM248 PON3 ATP9A PKD2L2 SLC35F3	1.79e-04	183	127	5	0f6799e4f058bed546fe5759502430f4a19635da
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP42 LPAR3 TRPC3 NID1 P2RY14	1.79e-04	183	127	5	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAPTM4B KCTD8 CAV1 PTPRQ C5	1.79e-04	183	127	5	ec2af3402b51f11466d2a5783a6b33746b6a7fc9
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-plasma_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM248 PON3 ATP9A PKD2L2 SLC35F3	1.79e-04	183	127	5	8ef5223e46f1fd81a856261248cc77e7c7e72ef6
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP42 LPAR3 TRPC3 NID1 P2RY14	1.84e-04	184	127	5	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP42 LPAR3 TRPC3 NID1 P2RY14	1.84e-04	184	127	5	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP42 LPAR3 TRPC3 NID1 P2RY14	1.84e-04	184	127	5	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	Leuk-UTI-Other-RBC\|Leuk-UTI / Disease, Lineage and Cell Type	HSP90B1 SELENBP1 SLC35F3 P2RY14 DAAM1	1.89e-04	185	127	5	5b5dd856d6efc0539d92533cff134bbc3f98be45
ToppCell	Leuk-UTI-Other\|Leuk-UTI / Disease, Lineage and Cell Type	HSP90B1 SELENBP1 SLC35F3 P2RY14 DAAM1	1.89e-04	185	127	5	895e8087e97ac0eab3446385e6e0dd24bea7f42c
ToppCell	Mild-Lymphoid-pDC\|Mild / Condition, Lineage, Cell class and cell subclass	SELL KCTD19 CLCN5 SLC35F3 P2RY14	1.93e-04	186	127	5	7fa82972c726025d6402e5eb7bf0db3b699eba4c
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP42 TRPC3 RGS11 NID1 P2RY14	1.93e-04	186	127	5	888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO AK4	1.93e-04	186	127	5	8287146f0ba415ea04475588117d4668ae00f75c
ToppCell	3'_v3-bone_marrow-Hematopoietic_Erythro-Mega\|bone_marrow / Manually curated celltypes from each tissue	SELENBP1 SLC16A9 LAPTM4B MBOAT2 ELOVL7	1.93e-04	186	127	5	9ff3c30b1728707bb8f9422941333fe3b2c430f4
ToppCell	Mild-Lymphoid-pDC-\|Mild / Condition, Lineage, Cell class and cell subclass	SELL KCTD19 CLCN5 SLC35F3 P2RY14	1.93e-04	186	127	5	1d05e73ae2ec0cc27f79e4fa40d6b21790059f80
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARHGAP42 TRPC3 CAV1 NID1 P2RY14	1.98e-04	187	127	5	fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO AK4	1.98e-04	187	127	5	1b82920588f9e26ef1db244d452736d75fcfd342
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO AK4	1.98e-04	187	127	5	71eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 SLC16A9 CDHR3 AGMO AK4	1.98e-04	187	127	5	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 KANSL1L CDHR3 IGF1R AGMO	1.98e-04	187	127	5	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 SLC16A9 CDHR3 AGMO AK4	1.98e-04	187	127	5	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	Mild_COVID-19-Myeloid-pDC\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	SELL KCTD19 CLCN5 SLC35F3 P2RY14	1.98e-04	187	127	5	99c3c4a7b9179dce7982dc6516d561c952abc80e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO AK4	1.98e-04	187	127	5	c1e4c0345f9bfa0538730bad5ff3fa5240168b25
ToppCell	COVID-19-kidney-Stressed_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	ARHGAP42 SLC16A9 CDHR3 AGMO AK4	1.98e-04	187	127	5	acd305475f3609800af0d7bc68d83ef41228080b
ToppCell	Leuk-UTI-Myeloid-pDC\|Leuk-UTI / Disease, Lineage and Cell Type	HSP90B1 TASL SLC35F3 P2RY14 DAAM1	1.98e-04	187	127	5	e3035b1f65ab12b8f01799b8e5d6633b9b584a06
ToppCell	VE-CD8-proli_CD4\|VE / Condition, Cell_class and T cell subcluster	CEL PKD2L2 NDUFAF6 CPLANE1	2.00e-04	101	127	4	5293f15b5ed340e6d0282b56de13752eabeef8dd
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LPAR3 SELENBP1 KCTD8 GSTK1 SLC35F3	2.03e-04	188	127	5	176a207dde6dd122a11e6c67c6299bc5179ff049
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LPAR3 SELENBP1 KCTD8 GSTK1 SLC35F3	2.03e-04	188	127	5	a6cbe58c5029acefbfbb64c3bff570de4e5e2449
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO AK4	2.03e-04	188	127	5	f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LPAR3 SELENBP1 KCTD8 GSTK1 SLC35F3	2.03e-04	188	127	5	6fb37e3b139955e6ee6be26ab6cd3ce85d765ca6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO AK4	2.03e-04	188	127	5	0792432cd4c564dea1102241ea9884f7ced7658c
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	SELENBP1 KCTD8 CAV1 CLDN1 PTPRQ	2.08e-04	189	127	5	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO AK4	2.08e-04	189	127	5	204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCell	Int-URO-Myeloid-pDC\|Int-URO / Disease, Lineage and Cell Type	HSP90B1 TASL SLC35F3 P2RY14 DAAM1	2.08e-04	189	127	5	37aee7a0acd5fd5dd62f22608d72ff8afe210e5c
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MMP27 ANO10 MBOAT2 IGF1R FAR2	2.08e-04	189	127	5	3b35022c0619df6db234613aa53a076899ca9562
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MMP27 ANO10 MBOAT2 IGF1R FAR2	2.08e-04	189	127	5	358ff514f1c8aa46067208ddf1b68396d789c130
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CDHR3 SLC7A9 AGMO AK4	2.08e-04	189	127	5	13fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell	facs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOBTB3 IL17D NID1 AK4 DAAM1	2.14e-04	190	127	5	990ac07f4b0a22041daac7502f74fafd6d258cba
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|World / Lineage and Cell class	MORC1 SLC37A1 LAPTM4B ELOVL7 FAR2	2.14e-04	190	127	5	1d19b2bd55789bf13e1386332f46c605973d6f8e
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-intermediate_monocyte\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MMP27 ANO10 MBOAT2 FAR2 GNAQ	2.14e-04	190	127	5	896b5825edb30fe62cbbed6078570c1f8057a99e
ToppCell	facs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOBTB3 IL17D NID1 AK4 DAAM1	2.14e-04	190	127	5	fc9bbe5e6e0ec3cfa47bf479d8b09a0fc53169cc
ToppCell	facs-Thymus-Flowthrough-24m-Mesenchymal\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOBTB3 IL17D NID1 AK4 DAAM1	2.14e-04	190	127	5	39ecdf8815e235771132684dfc1aff1917e20965
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELENBP1 KCTD8 CAV1 CLDN1 PTPRQ	2.19e-04	191	127	5	5343a527de6b0f852f45020a91f5b4869e78f13a
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELENBP1 KCTD8 CAV1 CLDN1 PTPRQ	2.19e-04	191	127	5	a25a5f9a380031fdaf57677a079f97a90f0550c0
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP42 TRPC3 RGS11 NID1 P2RY14	2.19e-04	191	127	5	1626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP42 TRPC3 RGS11 NID1 P2RY14	2.19e-04	191	127	5	716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCell	COVID-19-Lymphoid-pDC\|COVID-19 / Condition, Lineage and Cell class	SELL KCTD19 TASL SLC35F3 P2RY14	2.19e-04	191	127	5	25343b11d42128ad16659e5519cd1673266cc505
Drug	N-palmitoyl-L-tyrosine	LPAR3 GPR87 GPR45	3.12e-06	6	124	3	CID000389046
Drug	Brain Pi(4,5)p2	LPAR3 GPR87 GPR45	5.43e-06	7	124	3	CID005497157
Drug	VPC12249	LPAR3 GPR87 GPR45	8.66e-06	8	124	3	CID005311306
Drug	N-palmitoyl-serine	LPAR3 GPR87 GPR45	8.66e-06	8	124	3	CID000085997
Drug	fluoromethylene	LPAR3 GPR87 GPR45	1.29e-05	9	124	3	CID000186213
Disease	Dent disease (implicated_via_orthology)	CLCN3 CLCN4 CLCN5	7.24e-08	3	124	3	DOID:0050699 (implicated_via_orthology)
Disease	osteopetrosis (implicated_via_orthology)	CLCN3 CLCN4 CLCN5	2.50e-06	7	124	3	DOID:13533 (implicated_via_orthology)
Disease	clear cell renal cell carcinoma (is_implicated_in)	IGF1R MTHFR FTO	3.99e-06	8	124	3	DOID:4467 (is_implicated_in)
Disease	Phakomatosis cesioflammea	GNA11 GNAQ	1.75e-05	2	124	2	C3838883
Disease	Congenital hemangioma	GNA11 GNAQ	1.75e-05	2	124	2	C0235753
Disease	Port-wine stain with oculocutaneous melanosis	GNA11 GNAQ	1.75e-05	2	124	2	C1274879
Disease	portal vein thrombosis (is_implicated_in)	IGF1R MTHFR	5.24e-05	3	124	2	DOID:11695 (is_implicated_in)
Disease	cardiovascular system disease (is_implicated_in)	UBR1 MTHFR FTO	9.12e-05	21	124	3	DOID:1287 (is_implicated_in)
Disease	N,N-dimethylalanine measurement	SLC16A9 SLC6A20	1.05e-04	4	124	2	EFO_0800098
Disease	Malignant melanoma of iris	GNA11 GNAQ	1.74e-04	5	124	2	C0346373
Disease	Malignant melanoma of choroid	GNA11 GNAQ	1.74e-04	5	124	2	C0346388
Disease	linoleoylcarnitine (C18:2) measurement	SLC16A9 SLC22A16	1.74e-04	5	124	2	EFO_0800338
Disease	pseudotumor cerebri	OR9G1 OR9G9 PARP4	1.75e-04	26	124	3	EFO_1001132
Disease	glucose measurement	OR9G1 VPS13C OR9G9 IGF1R ABITRAM AGMO NDUFAF6 FTO	2.11e-04	380	124	8	EFO_0004468
Disease	intellectual disability (is_implicated_in)	ACSL4 SLC6A8 CDK13	2.71e-04	30	124	3	DOID:1059 (is_implicated_in)
Disease	Spinocerebellar Ataxia Type 2	WWOX TRPC3 ANO10	3.94e-04	34	124	3	C0752121
Disease	Spinocerebellar Ataxia Type 1	WWOX TRPC3 ANO10	3.94e-04	34	124	3	C0752120
Disease	Spinocerebellar Ataxia Type 5	WWOX TRPC3 ANO10	3.94e-04	34	124	3	C0752123
Disease	Spinocerebellar Ataxia Type 7	WWOX TRPC3 ANO10	3.94e-04	34	124	3	C0752125
Disease	Spinocerebellar Ataxia Type 6 (disorder)	WWOX TRPC3 ANO10	3.94e-04	34	124	3	C0752124
Disease	Ataxia, Spinocerebellar	WWOX TRPC3 ANO10	3.94e-04	34	124	3	C0087012
Disease	Spinocerebellar Ataxia Type 4	WWOX TRPC3 ANO10	4.30e-04	35	124	3	C0752122
Disease	QT interval	TEKT3 LAPTM4B SLC19A2 CAV1 SCAP FAR2 CDK13 MIGA1 ROS1	4.39e-04	534	124	9	EFO_0004682
Disease	Uveal melanoma	GNA11 GNAQ	4.82e-04	8	124	2	C0220633
Disease	C-reactive protein measurement	OR9G1 WWOX CEL VPS13C CDHR3 KCTD8 ATP9A OR9G9 NEO1 DNAH17 SLC17A8 NID1 AK4 FTO	5.57e-04	1206	124	14	EFO_0004458
Disease	platelet glycoprotein ib alpha chain measurement	AK3 AK4	7.71e-04	10	124	2	EFO_0020645
Disease	PR segment	CAV1 IL17D	7.71e-04	10	124	2	EFO_0005095
Disease	retinal nerve fibre layer thickness measurement	NBAS SLC6A20 DAAM1	7.91e-04	43	124	3	EFO_0600004
Disease	liver cirrhosis (is_implicated_in)	IGF1R MTHFR C5	7.91e-04	43	124	3	DOID:5082 (is_implicated_in)
Disease	Congenital Heart Defects	MTHFR GNA11 GNAQ	8.46e-04	44	124	3	C0018798
Disease	arachidonoylcarnitine (C20:4) measurement	SLC16A9 SLC22A16	1.12e-03	12	124	2	EFO_0800544
Disease	ghrelin measurement	WWOX CLDN1 IGKV2D-26	1.16e-03	49	124	3	EFO_0600001
Disease	cleft lip	WWOX FRMD1 FRY SLC35F3 AGMO NID1	1.30e-03	284	124	6	EFO_0003959
Disease	dihomo-linolenoylcarnitine (C20:3n3 or 6) measurement	SLC16A9 SLC22A16	1.33e-03	13	124	2	EFO_0800547
Disease	Mental Retardation, X-Linked Nonsyndromic	ACSL4 CLCN4	1.33e-03	13	124	2	C3501611
Disease	glucose metabolism measurement, age-related hearing impairment	WWOX ATP9A DPY19L4	1.38e-03	52	124	3	EFO_0005782, EFO_0009367
Disease	Hereditary Diffuse Gastric Cancer	WWOX SELENBP1 CAV1 NBAS CLCN3 MTHFR	1.53e-03	293	124	6	C1708349
Disease	acute graft vs. host disease	LPAR3 WWOX PKD2L2	1.54e-03	54	124	3	EFO_0004599
Disease	nephroblastoma (is_implicated_in)	IGF1R MTHFR	1.54e-03	14	124	2	DOID:2154 (is_implicated_in)
Disease	obsolete_red blood cell distribution width	ARHGAP42 SELENBP1 CEL SWAP70 AK3 NEO1 IGF1R SLC22A16 MTHFR AK4 MIGA1 GNAQ FTO SMAD7	1.60e-03	1347	124	14	EFO_0005192
Disease	Stomach Neoplasms	WWOX SELENBP1 CAV1 NBAS CLCN3 MTHFR	1.64e-03	297	124	6	C0038356
Disease	Malignant neoplasm of stomach	WWOX SELENBP1 CAV1 NBAS CLCN3 MTHFR	1.72e-03	300	124	6	C0024623
Disease	pyroglutamine measurement	RHOBTB3 FAR2 SLC6A20	1.89e-03	58	124	3	EFO_0005408
Disease	atherosclerosis (is_implicated_in)	PON3 MTHFR	2.02e-03	16	124	2	DOID:1936 (is_implicated_in)
Disease	preeclampsia, hypertension, pregnancy-induced	MTHFR FTO	2.02e-03	16	124	2	EFO_0000668, MONDO_0024664
Disease	retinal layer thickness measurement	NBAS SLC6A20 DAAM1	2.08e-03	60	124	3	EFO_0600002
Disease	Calcium channel blocker use measurement	ARHGAP42 SWAP70 MTHFR DPY19L4 FTO	2.10e-03	213	124	5	EFO_0009930
Disease	squamous cell carcinoma (is_implicated_in)	WWOX MTHFR	2.56e-03	18	124	2	DOID:1749 (is_implicated_in)
Disease	left ventricular mass	IGF1R FTO	2.56e-03	18	124	2	EFO_0009289
Disease	Epstein-Barr virus infection	WWOX SLC6A2 SLC35F3	2.73e-03	66	124	3	EFO_0000769
Disease	Pseudopelade	CLDN1 MTHFR	2.86e-03	19	124	2	C0086873
Disease	Alopecia	MTHFR LSS	2.86e-03	19	124	2	C0002170
Disease	renal cell carcinoma (is_implicated_in)	EGLN2 MTHFR FTO	3.10e-03	69	124	3	DOID:4450 (is_implicated_in)
Disease	acetate measurement	AK3 AK4	3.17e-03	20	124	2	EFO_0010112
Disease	Malignant Glioma	CLCN3 CLCN5 ROS1	3.23e-03	70	124	3	C0555198
Disease	mixed gliomas	CLCN3 CLCN5 ROS1	3.23e-03	70	124	3	C0259783
Disease	HbA1c measurement, response to sulfonylurea	SLC16A9 GXYLT1	3.49e-03	21	124	2	EFO_0004541, EFO_0007922
Disease	Nephritis, Tubulointerstitial	SLC7A9 CLCN5	3.49e-03	21	124	2	C0041349
Disease	lymphocyte count, response to vaccine	TEKT3 NBAS	3.83e-03	22	124	2	EFO_0004587, EFO_0004645
Disease	Immunologic Deficiency Syndromes	NBAS C5	4.18e-03	23	124	2	C0021051

Protein segments in the cluster

Peptide	Gene	Start	Entry
FSYEVLTPLKWYQSI	AMELX	31	Q99217
IYSALIFIPWYFLTN	ACSL4	21	O60488
YTSLLKESFPSVWYT	AGBL3	426	Q8NEM8
AISPWKTYQLVYFLD	RNPEP	526	Q9H4A4
QIYTSWIFYSPLALF	AGMO	166	Q6ZNB7
SFRYPWARLYSTSQT	COQ3	76	Q9NZJ6
VVPSLVDRYFTRWYK	ABITRAM	11	Q9NX38
EVSYYFPLKTLWRSF	CLCN4	281	P51793
LKAYTPVVVTLWYRA	CDK11B	591	P21127
TWPRKLPVEQFYYLT	C7orf31	101	Q8N865
TNFLRYWTLTYLALP	CEL	536	P19835
RLATFWYYAKVELVP	ATP5MG	26	O75964
TFTVTKYWFYRLLSA	CAV1	91	Q03135
ESRPYTNKVITLWYR	CDK13	866	Q14004
SFLDLWYSSVYTPKI	OR9G1	66	Q8NH87
TPYRFQTPYFWTSTL	RGS11	101	O94810
SKALFRTIITYPWFQ	GNAQ	251	P50148
WYATTLQTLLKYPEL	KCTD19	406	Q17RG1
FPARWSFRAYTSVLY	MORC1	231	Q86VD1
WYTRFALKYQPIDSI	ANO10	186	Q9NW15
LIRDWPNIYTYTKAL	FAR2	196	Q96K12
FKWINTLYLYVATLI	SLC16A9	366	Q7RTY1
YTLPGWRKYNLTYRI	MMP27	101	Q9H306
WRKYNLTYRIINYTP	MMP27	106	Q9H306
FWASRPKSYIYRTQE	MTHFR	366	P42898
RKLYRLSPTFYWTPQ	KANSL1L	571	A0AUZ9
WSSYTEYIFFRPPQK	KCTD8	311	Q6ZWB6
ATASWPTKIIYLYIS	MBOAT2	266	Q6ZWT7
YKYLNTRLFTVPWPV	FTO	106	Q9C0B1
KIWPYVYTLFSNKIT	AK4	201	P27144
TNKIWPYVYAFLQTK	AK3	201	Q9UIJ7
PNLTVIRGWKLFYNY	IGF1R	101	P08069
SIIYYVSRSPKLEVW	PCNX3	1491	Q9H6A9
AKIWTSVPYLASYVS	PCSK7	476	Q16549
TYLYWFLQKARPVST	IGKV2D-26	56	A0A0A0MRZ7
WYQQKLGSSPRLFLY	IGLV11-55	56	A0A075B6I3
FIYVWPFSRYSVDKI	OR4K13	256	Q8NH42
KNTLLPLYLYIQSWR	NDUFAF6	316	Q330K2
PSRIYTYQWRQTITF	NID1	601	P14543
SSYLDFTNPKVREWY	GANC	476	Q8TET4
WSFLQTFNYTLYPIT	GXYLT1	166	Q4G148
AISYTSYRNIFPIWA	LSS	701	P48449
LPYWLYLTAETLKNR	NPIPB8	246	E9PQR5
TYGAYKQRAAWIIPF	LAPTM4B	181	Q86VI4
PIYSRSYLVFWTVSN	LPAR3	181	Q9UBY5
LEKTLPFSRSYYWIG	SELL	76	P14151
TNLRSVSPWAYRISY	IL17D	86	Q8TAD2
PTKTYSNEVVTLWYR	CDK17	341	Q00537
YKTFLIWVLISIYQG	ATP9A	921	O75110
LSYIRIFWTVFKIPS	OR1I1	216	O60431
TDFWKTLRYLSLLYP	PARP4	951	Q9UKK3
SFLDLWYSSVYTPKI	OR9G9	66	P0C7N8
SSSPWVTFVYALYQI	MFSD6	691	Q6ZSS7
LSAWRVLSGSPYYKQ	NBAS	271	A2RRP1
WLSYLKSVFNPIVYC	GPR45	311	Q9Y5Y3
PWYFKFILCRYTSVL	GPR87	106	Q9BY21
IIDKLTIFSYYTFWL	PTPRQ	1056	Q9UMZ3
FWYTSVYTPKILASC	OR9G4	86	Q8NGQ1
YSQFINFPIYVWSSK	HSP90B1	271	P14625
PYKRSGNTVQYWLLL	DAAM1	391	Q9Y4D1
LVSYTFLFWLPLYIT	SLC37A1	341	P57057
SYFPQWIITKRGIDY	FRMD1	211	Q8N878
AIVSTALPQWRIYSY	CLDN1	21	O95832
TSLWLLEQPYFATYK	CPLANE1	1786	Q9H799
IWATSEYYNTPARII	DNAH17	321	Q9UFH2
VYKTRIRGPTYVWTF	DNAH17	4426	Q9UFH2
FWYRAYTKGQRLPKT	ELOVL7	256	A1L3X0
TYQVLRKNVYSPSAW	CDHR3	696	Q6ZTQ4
RKNVYSPSAWYVPFV	CDHR3	701	Q6ZTQ4
SKPTWEYLYCVLFIL	SLC7A9	431	P82251
FSFRYIYPLDSLTWI	C5	1631	P01031
SKALFRTIITYPWFQ	GNA11	251	P29992
RTVELFYDVLSPYSW	GSTK1	6	Q9Y2Q3
LEEVSYYFPLKTLWR	CLCN5	336	P51795
YWRLLVPGTYKITAS	CPD	831	O75976
WNRSYFVYKINTVIS	DPY19L4	706	Q7Z388
YIRLLNYFTWPTTTS	ASIC5	81	Q9NY37
LYTYPENWRAFKALI	EEF1G	6	P26641
KPAYATRYAITVWYF	EGLN2	361	Q96KS0
TALSYAWPYAFTRLQ	FRY	871	Q5TBA9
VWTYSYLVLLFPVFL	SLC19A2	76	O60779
RHWPTLFSYYNITLA	SCAP	631	Q12770
IILSPLQCTKYIVWY	CFAP47	2596	Q6ZTR5
SSWSVNYQPLKYTRL	NLGN2	296	Q8NFZ4
TLRQWIYYFPKVVKT	NXPE1	356	Q8N323
LFYISSSLTYFWPKS	OR10A5	251	Q9H207
TYQARKPLWFYNTSL	RHOBTB3	396	O94955
SWVYFRPLSSYSVTK	OR1Q1	256	Q15612
WKTTETYRASLPYSQ	PIGS	36	Q96S52
RVFDLPLTWYYSLSQ	MIGA1	51	Q8NAN2
DFLPWKSLTSIIEYY	MTA3	296	Q9BTC8
QLFRSLVPIQLWYKY	RNFT2	306	Q96EX2
LVPWNSTFYTIQTYV	RXFP4	276	Q8TDU9
KWNTRIETYYFPSLK	TAS2R41	171	P59536
IETYYFPSLKLVIWS	TAS2R41	176	P59536
IYVIYKFLSTQGSLW	SLC6A2	571	P23975
VALFKLQSYWLPNFY	RGSL1	181	A5PLK6
PDTYSNATLWYKIFT	TMEM248	206	Q9NWD8
SWVVYGTNYRKAIFI	TOR2A	181	Q8N2E6
YLYVQEKRPLGFTWI	ARHGAP42	271	A6NI28
LSYLFYNWSITKRTL	SLC22A16	346	Q86VW1
TDSRYYTVRWKTNIP	NEO1	886	Q92859
YTVRWKTNIPANTKY	NEO1	891	Q92859
LSLPWRPSTYYKVAS	TEKT3	46	Q9BXF9
YLNSWRPSLFYKIAN	TEKT5	46	Q96M29
ITTSLYSAWDKQFYP	SELENBP1	401	Q13228
VYRSYKPVFWSPSSR	IARS2	236	Q9NSE4
FYYLVKSFTTTLPWA	SLC6A8	156	P48029
SFDRYYKIVKPLWTS	P2RY14	116	Q15391
QYFWYRKTLNISPSL	SLC6A20	146	Q9NP91
CIPIILYFTKVEYWS	SLC35F3	281	Q8IY50
LHYFTNSLYSVWPLV	PIGW	196	Q7Z7B1
SLEEVSYYFPLKTLW	CLCN3	336	P51790
NPTKTFYYKSRFWLL	XPR1	361	Q9UBH6
SWVVYGTNYRKAIFI	TOR2A	181	Q5JU69
YRKTVWPRAYNLTNF	SETDB2	271	Q96T68
WVYNRSSYPIFIKSA	SMAD7	331	O15105
YTVSPFSNLRWYKQD	TRAV10	46	A0A0B4J240
FPQKPIQRYSSYWRI	TASL	176	Q9HAI6
YLWVSLKNGITPYLR	UBR1	1496	Q8IWV7
WVYTLLFTLARPFTK	WWOX	336	Q9NZC7
PSVNWLISYSKYMRA	ATP6V1A	446	P38606
PYWLINKTTRVLQYR	VPS13C	2771	Q709C8
WTYVLFYSPREVKVV	PON3	201	Q15166
ISFSVYPLLSRLYWT	ROS1	1276	P08922
YPLLSRLYWTEVSNF	ROS1	1281	P08922
LTSWQFYSVKLLRYV	PKD2L2	261	Q9NZM6
WFVLKPNIISYYVSE	SWAP70	231	Q9UH65
ALFPLTARSTYYMWK	VRTN	676	Q9H8Y1
PTYRNSITVPYKVWA	PURA	251	Q00577
SSPLISLWINRFYIY	TYW1B	11	Q6NUM6
RAATFTYSPLLYWIN	TEX38	56	Q6PEX7
EIQYFTYARDKWLPS	TRPC3	506	Q13507
RSWTFYLLLISQPAY	SLC17A8	326	Q8NDX2
ISAQSYPSRWTYIEF	MYO5C	681	Q9NQX4
QQTLRLKYPLWSRYG	GRIN2D	406	O15399