Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesscell cycle process

FOXJ2 PTPRC IK ALMS1 CDC25A KLHL18 BAG6 CDK10 WAC

4.06e-051441269GO:0022402
MousePhenoabnormal bone marrow cell morphology/development

EPS8L2 PTPRC IL1R1 CNN2 TLE4 WAC SOS1

5.08e-05706217MP:0002398
MousePhenoincreased apoptosis

PTPRC ALMS1 CDC25A BAG6 TLE4 SYNE2 SOS1 MPI

6.19e-051008218MP:0006042
MousePhenoincreased cell death

PTPRC ALMS1 CDC25A BAG6 TLE4 SYNE2 SOS1 MPI

6.69e-051019218MP:0012556
DomainWW

SMURF2 WAC

1.94e-0347262PF00397
DomainWW

SMURF2 WAC

2.02e-0348262SM00456
DomainWW_DOMAIN_2

SMURF2 WAC

2.28e-0351262PS50020
DomainWW_DOMAIN_1

SMURF2 WAC

2.28e-0351262PS01159
DomainWW_dom

SMURF2 WAC

2.37e-0352262IPR001202
DomainCH

CNN2 SYNE2

3.67e-0365262SM00033
DomainCH

CNN2 SYNE2

4.25e-0370262PF00307
Domain-

CNN2 SYNE2

4.37e-03712621.10.418.10
DomainCH

CNN2 SYNE2

4.61e-0373262PS50021
DomainCH-domain

CNN2 SYNE2

4.86e-0375262IPR001715
Pubmed

Cutting Edge: IL-1R1 Mediates Host Resistance to Mycobacterium tuberculosis by Trans-Protection of Infected Cells.

PTPRC IL1R1

5.80e-07227230068597
Pubmed

Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.

PTPRC SMURF2

1.74e-06327222552287
Pubmed

CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production.

PTPRC SOS1

1.74e-06327215661907
Pubmed

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells.

PTPRC SOS1

5.80e-0652728632004
Pubmed

The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.

EPS8L2 SOS1

1.62e-05827214565974
Pubmed

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.

PTPRC IL1R1

2.08e-05927232561755
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

RERE PTPRC KANSL1 BAG6 TLE4 SOS1

2.37e-0577427615302935
Pubmed

IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms.

PTPRC IL1R1

3.81e-051227226011644
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

RERE IK TLE4 WAC

5.26e-0526827433640491
Pubmed

Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.

PTPRC IL1R1

6.92e-05162728875997
Pubmed

Functional proteomics mapping of a human signaling pathway.

PIAS4 PTPRC KANSL1 BAG6 SMURF2

8.25e-0559127515231748
Pubmed

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1.

TLE4 SYNE2

8.81e-051827233361760
Pubmed

Interaction network of human early embryonic transcription factors.

PIAS4 RERE ALMS1 TLE4

1.49e-0435127438297188
Pubmed

The protein interaction landscape of the human CMGC kinase group.

ALMS1 BAG6 GLCCI1 CDK10 TLE4

1.76e-0469527523602568
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

KANSL1 WAC SOS1

2.17e-0415127317043677
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

PIAS4 CDC25A KLHL18 SMURF2 CDK10

2.21e-0473027534857952
Pubmed

The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.

EPS8L2 SYNE2

2.49e-043027230480076
Pubmed

Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.

FOXJ2 BAG6

2.84e-043227227739607
Pubmed

Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.

PTPRC CDC25A

5.14e-044327230733279
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

RERE KANSL1

5.14e-044327233472061
Pubmed

Analyses of shared genetic factors between asthma and obesity in children.

IL1R1 TLE4

6.14e-044727220816195
Pubmed

Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.

CDC25A SOS1

6.67e-044927223397142
Pubmed

LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation.

EPS8L2 PTPRC

6.95e-045027231323030
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

FOXJ2 RERE KANSL1 SOS1

7.39e-0453627415840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

FOXJ2 RERE KANSL1 SOS1

7.49e-0453827410512203
InteractionTTC14 interactions

AMPD3 IK CDK10

5.41e-0628253int:TTC14
CytobandEnsembl 112 genes in cytogenetic band chr11p15

AMPD3 EPS8L2 OLFML1

4.33e-03564273chr11p15
CoexpressionGSE20715_0H_VS_48H_OZONE_LUNG_UP

EPS8L2 PTPRC IK GLCCI1 CNN2

1.73e-06200275M4368
CoexpressionGSE32533_WT_VS_MIR17_KO_ACT_CD4_TCELL_DN

KANSL1 BAG6 SMURF2 WAC

4.74e-05197274M8464
CoexpressionGSE3982_BASOPHIL_VS_TH1_UP

MGAM RERE PTPRC IK

4.93e-05199274M5564
CoexpressionGSE31082_DN_VS_CD4_SP_THYMOCYTE_DN

FOXJ2 RERE PTPRC KLHL18

5.03e-05200274M5059
CoexpressionGSE5503_PLN_DC_VS_SPLEEN_DC_ACTIVATED_ALLOGENIC_TCELL_DN

PTPRC SMURF2 TLE4 WAC

5.03e-05200274M297
CoexpressionGSE36888_STAT5_AB_KNOCKIN_VS_WT_TCELL_IL2_TREATED_6H_DN

ALMS1 SMURF2 GLCCI1 TLE4

5.03e-05200274M8745
CoexpressionGSE17721_CPG_VS_GARDIQUIMOD_8H_BMDC_DN

FOXJ2 AMPD3 KANSL1 SYNE2

5.03e-05200274M3893
CoexpressionVERHAAK_GLIOBLASTOMA_MESENCHYMAL

AMPD3 PTPRC IL1R1 CNN2

6.78e-05216274M2122
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

PTPRC KANSL1 IK SMURF2 GLCCI1 CNN2 WAC SOS1

9.06e-051492278M40023
CoexpressionRODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN

RERE KANSL1 ALMS1 GLCCI1 CDK10 SYNE2

1.42e-04807276M16651
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-mature_NK_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MGAM PTPRC SYNE2 SOS1

3.46e-0617327436a471576a9d2325066bb14c2f2cd89c67b92915
ToppCellCF|World / Disease state, Lineage and Cell class

MGAM AMPD3 IL1R1 SYNE2

4.71e-06187274eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

PTPRC KANSL1 KLHL18 SYNE2

4.81e-06188274ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellCOVID-19-kidney-Myeloid|COVID-19 / Disease (COVID-19 only), tissue and cell type

MGAM AMPD3 PTPRC IL1R1

5.22e-061922740b9d22a222f1201e375f8e55cace9ef939febae4
ToppCellCOVID-19-Lymphoid-Tregs|COVID-19 / Condition, Lineage and Cell class

PTPRC IL1R1 GLCCI1 SYNE2

5.55e-06195274284cfff4d59ecc1430997b118de17fee167dcbb1
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

RERE KANSL1 GLCCI1 SOS1

5.67e-06196274ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MGAM PTPRC CNN2 SYNE2

6.02e-061992745919933c4b842b98fc98685dc8c72c8dd32c6ea3
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MGAM PTPRC CNN2 SYNE2

6.02e-06199274caf2e050b21e7a16ce4e51b3f135debd06810231
ToppCellNS-moderate-d_16-33-Epithelial-unknown_epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EPS8L2 RERE TLE4

7.66e-0513727303e124901a0e85b59b6882bbafab568b50907e8b
ToppCellmoderate-Epithelial-unknown_epithelial|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

EPS8L2 RERE TLE4

7.82e-05138273afefa8233c67aa744e939156bc538449bf6bd05b
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

PTPRC KANSL1 SYNE2

1.13e-041562731545169694f686d28648a68b552c2ae606599d66
ToppCellCV-Mild-4|CV / Virus stimulation, Condition and Cluster

EPS8L2 CNN2 MPI

1.21e-04160273be89efeeecb0de96ce136a7a62738f15dc0badb2
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CATSPERB PTPRC SYNE2

1.26e-0416227319395bdb282b4a2d88cd33191af12c24a88c3d16
ToppCellnormal-na-Lymphocytic_T-T4_reg-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

PTPRC CDC25A SYNE2

1.28e-0416327343887e7687fc6367efac0c1f56a9534b06f47b7f
ToppCellControl-T_cells-Tregs|Control / group, cell type (main and fine annotations)

PTPRC GLCCI1 SYNE2

1.43e-04169273e1e0983f31ec81b3fad5f9c6140d17f03f81a5dc
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

EPS8L2 GLCCI1 SYNE2

1.45e-04170273a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRC CNN2 SYNE2

1.48e-04171273e1fe07652c10c37191d1471ddaea500f74269e0c
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

PTPRC KANSL1 SYNE2

1.48e-041712732e9a20f8980b78325c52065a9c14ab3656267c05
ToppCelldroplet-Liver-nan-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXJ2 AMPD3 TTLL13

1.50e-04172273f814b6134ad608015765399d54cc1e5e1873ed34
ToppCellCTRL-Myeloid-Neutrophil|CTRL / Disease state, Lineage and Cell class

MGAM PTPRC SYNE2

1.50e-04172273ef3a6fe3b7300959f9f71130200c7fb8741c42b0
ToppCellCOVID-19_Severe-CD4+_CTL|COVID-19_Severe / disease group, cell group and cell class

CATSPERB PTPRC SYNE2

1.63e-0417727334e9455790bae905dd91923792f4109d18b7686e
ToppCellControl-Lymphocyte-T_NK-CD4_CTL|Control / Disease, Lineage and Cell Type

PTPRC GLCCI1 SYNE2

1.66e-0417827332fbb7a8d7daa7cb37f42923514acbb9090e6811
ToppCellControl-Lymphoid-T_Regulatory|World / Disease state, Lineage and Cell class

IL1R1 GLCCI1 SYNE2

1.72e-0418027347036eee4c128fbb443d1fc767b4de5cced93f0e
ToppCellCOVID-19-T_cells-Tregs|COVID-19 / group, cell type (main and fine annotations)

PTPRC GLCCI1 SYNE2

1.74e-04181273534659cf754326c6a73c0daa30e9d610612a0292
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

PTPRC KANSL1 SYNE2

1.74e-04181273f2315414e714ac86211546a935660c4be6e85f1b
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MGAM PTPRC CNN2

1.77e-04182273dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PTPRC IK SYNE2

1.86e-04185273115a74d0b9be580005d45d22d6e228801b2705e2
ToppCellCOPD-Lymphoid-T_Regulatory|COPD / Disease state, Lineage and Cell class

IL1R1 GLCCI1 SYNE2

1.86e-04185273846403edd4c8f646201d519055198fc38b7ffff9
ToppCellT_cells-GZMK+_CD8+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

PTPRC CNN2 SYNE2

1.98e-04189273e2ca075aedf7c370ab4ede6272254ffd06cbcdec
ToppCellIPF-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

PTPRC TLE4 WAC

1.98e-041892735c22d2d935f7bb270260b8bc6be67b565ec401bf
ToppCellCOPD-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

PTPRC TLE4 WAC

2.01e-04190273aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCellCOPD-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

PTPRC TLE4 WAC

2.01e-04190273ed978cd5d9da87b49878a330e362762c487f849f
ToppCell10x5'-blood-Lymphocytic_T_CD8-Trm/em_CD8|blood / Manually curated celltypes from each tissue

PTPRC CNN2 SYNE2

2.01e-04190273e1f474dc36bf9eaf457b14a8761d287904754cdc
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_em-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PTPRC IK SYNE2

2.01e-04190273f6616b3fe7f4962249503c96c06926240066d861
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-regulatory_T_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PTPRC GLCCI1 SYNE2

2.01e-04190273b69709323a9f1b368b5a4f87295b9f7fd9c9be8e
ToppCellCOPD-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

IL1R1 GLCCI1 SYNE2

2.04e-041912733ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCellILEUM-non-inflamed-(1)_Tregs|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PTPRC IL1R1 GLCCI1

2.04e-04191273e065d16a1f88c91dec576d248a318534ceab1cb2
ToppCellCOPD-Lymphoid|COPD / Disease state, Lineage and Cell class

PTPRC GLCCI1 SYNE2

2.08e-04192273064fefb8212fadab0ff441f4bf643559b7fdb25d
ToppCellCOPD-Lymphoid-T_Cytotoxic|World / Disease state, Lineage and Cell class

PTPRC GLCCI1 SYNE2

2.08e-041922735bfd9f5d47511441eb2d3cc3c4d7ed330ffd0bd1
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

RERE KANSL1 SOS1

2.08e-04192273916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellCOPD-Lymphoid-T|World / Disease state, Lineage and Cell class

PTPRC GLCCI1 SYNE2

2.08e-04192273eb4909574fb5fc91399463523e2737095773200a
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-Treg-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PTPRC GLCCI1 SYNE2

2.08e-04192273d85a785a12076e34c404171363a647f318926b18
ToppCellnormal_Lymph_Node-T/NK_cells-Treg|normal_Lymph_Node / Location, Cell class and cell subclass

PTPRC GLCCI1 SYNE2

2.08e-04192273d2c2a98d331522a3ab7973bfaf4396ef4d684888
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-Tregs|lymph-node_spleen / Manually curated celltypes from each tissue

IL1R1 GLCCI1 SYNE2

2.08e-0419227391a4d06e8d1d1fe2ce5f72668108513bd2a72c4d
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-Treg|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PTPRC GLCCI1 SYNE2

2.08e-04192273230f3090607a62bb6d1e1f4b0341ee96d93f1c00
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PTPRC CNN2 SYNE2

2.08e-04192273ed1fb700d3e8f00495727d61e164fc0b70274fd0
ToppCellILEUM-inflamed-(1)_Tregs|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PTPRC IL1R1 SYNE2

2.08e-041922731fe3417dfd1cf1758fd82c9ac13dbd88bdf0b548
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PTPRC CNN2 SYNE2

2.08e-041922736779b0294bb058e748e22b795b6a381c4add37e9
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

PTPRC KANSL1 SYNE2

2.08e-0419227347646d7e4990be85072987f92bf18d52f8da752e
ToppCellILEUM-non-inflamed-(1)_CD8_Trm|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PTPRC TLE4 SYNE2

2.08e-04192273a9f89043c97cd2b0ba165e69ee5681094410af37
ToppCellCD8+_Memory_T_cell-CV-0|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

PTPRC GLCCI1 SYNE2

2.11e-04193273995781d87a919c0380750878bafe584342bb83ad
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

RERE KANSL1 SOS1

2.11e-04193273e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellCOVID-CD8-CD8_1|COVID / Condition, Cell_class and T cell subcluster

PTPRC CNN2 SYNE2

2.11e-04193273221690901cb214c8ee186ff527c80dcc52d1fb1c
ToppCellfacs-Thymus-nan-3m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRC GLCCI1 WAC

2.14e-04194273f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCellfacs-Thymus-nan-3m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRC GLCCI1 WAC

2.14e-0419427366c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCellfacs-Thymus-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRC GLCCI1 WAC

2.14e-04194273cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCellCOVID_vent-Myeloid-Monocytic-Developing_Neutrophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

MGAM AMPD3 IL1R1

2.17e-04195273de23409b1b4146b8ae286850b829ec8dceed0117
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-LZ_GC_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPRC CNN2 SYNE2

2.17e-04195273cccc9c70bb8f6df8c6ab94534c17475af1d3e224
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

EPS8L2 GLCCI1 SYNE2

2.17e-04195273dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CATSPERB EPS8L2 GLCCI1

2.17e-04195273d673f8844896d5c7b76a7bc7f6b88a039f1bc263
ToppCellCOVID-19-Lymphoid-Tregs|Lymphoid / Condition, Lineage and Cell class

IL1R1 GLCCI1 SYNE2

2.17e-041952739ad844d9d5aac39d133ae8ab9c4839300f08064c
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRC CNN2 SYNE2

2.20e-0419627326f626e4df364e458431a5eccae076d1bed94ed4
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRC KANSL1 CNN2

2.20e-0419627337065ac2c89a8b5ed52af9f796e0c97909ee51a4
ToppCell10x5'-Lung-Lymphocytic_T_CD8-Trm/em_CD8|Lung / Manually curated celltypes from each tissue

PTPRC CNN2 SYNE2

2.20e-04196273cbb63b9ea85b2060e90dd551aa4e697b3f1494fc
ToppCellmoderate-Lymphoid-Treg|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PTPRC IL1R1 TLE4

2.20e-041962739152f4a8a27ff4ee28f231c5ad00eb2edd9ea6da
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRC CNN2 SYNE2

2.20e-04196273578afe58962a24874b99b0407a647b12e972344b
ToppCell10x5'-Liver-Lymphocytic_T_CD8-Trm/em_CD8|Liver / Manually curated celltypes from each tissue

PTPRC GLCCI1 CNN2

2.20e-0419627391c85ea202508185142ef67af6d27d0932567ca0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRC CNN2 SYNE2

2.20e-041962738b63b29eb305fe05c967e47468318c60e9461a2d
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PTPRC CNN2 SYNE2

2.24e-04197273adc7bf2120fad4aea58123d882a8cf18ed4174d0
ToppCellT_cells-Treg_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

PTPRC GLCCI1 SYNE2

2.24e-04197273de5448fcdf4e433fc167496413abe5d0c8a5c6d8
ToppCellCOVID-CD8|COVID / Condition, Cell_class and T cell subcluster

PTPRC CNN2 SYNE2

2.24e-041972734c61ea7eba706bdc7345745941ae8b9f6a21e844
ToppCellCOVID-CD4-exh_CD4|COVID / Condition, Cell_class and T cell subcluster

PTPRC CNN2 SYNE2

2.24e-0419727339ee4b93625c994813044d8dd8854fba2bd99940
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PTPRC CNN2 SYNE2

2.24e-04197273e133bd09efc6d7f539fc1a1ac7a945f07103d6e6
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRC CNN2 SYNE2

2.27e-04198273e63bbf0ec2a2ffe49e038a692033df71f5c8da14
ToppCellsystemic_lupus_erythematosus-treated|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PTPRC TLE4 SYNE2

2.27e-041982738165ff735095c52994fb5057d89be93cc378b7da
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

AMPD3 CNN2 SYNE2

2.27e-041982733bc05b8d97a7219af40db7a11aa271f02e74fca5
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PTPRC TLE4 SYNE2

2.27e-041982734c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

RERE KANSL1 GLCCI1

2.27e-041982731996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-neutrophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MGAM PTPRC SYNE2

2.27e-04198273e76061e66f6d60f5735962aa7777dda8958caed9
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRC CNN2 SYNE2

2.31e-041992730a5b842c79ec56ffd6a961f41a956b4a974d5e03
ToppCellCaecum-(1)_T_cell-(15)_Treg|Caecum / shred on region, Cell_type, and subtype

PTPRC IL1R1 SYNE2

2.31e-0419927312c22b07a231c9dc548e9dc37e0a60296a4a6273
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRC CNN2 SYNE2

2.31e-0419927333b69b7b1542cc826380cb4f2629c422b7f85c9a
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL1R1 OLFML1 CNN2

2.31e-04199273dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-neutrophil-neutrophil|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MGAM PTPRC SYNE2

2.31e-0419927386f2857ce60fbe59375411373ff49c684fd66ad0
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

RERE KANSL1 SOS1

2.31e-0419927394b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PTPRC CNN2 SYNE2

2.31e-04199273b270d8274249103d3a1b4a4f8601c92fde007ed7
ToppCellBAL-Severe-Lymphocyte-T/NK|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PTPRC CNN2 SYNE2

2.31e-0419927328cec7122b143373f1c7c94acf35bf8f896e0d57
ToppCellCaecum-T_cell-Treg|Caecum / Region, Cell class and subclass

PTPRC IL1R1 SYNE2

2.31e-04199273ab0b32c077ac26d32a293dcf686af6984980793f
ToppCellSevere_COVID-19-T/NK|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

PTPRC CNN2 SYNE2

2.31e-04199273ace179b860513179e9275ed40ae1985a98385026
ToppCellCOVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil|COVID-19_Mild / Disease, condition lineage and cell class

MGAM AMPD3 CDC25A

2.31e-04199273e222b90caf45904d8f763574e7b6aac13333df92
ToppCellBAL-Severe-Lymphocyte-T/NK|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PTPRC CNN2 SYNE2

2.31e-04199273c8a2c94809b2134b51bb9868b63cb280b490f3fe
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

AMPD3 CNN2 SYNE2

2.31e-04199273a1635a52318be0423f8e4fc03d971c28cd22b57e
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

KANSL1 GLCCI1 WAC

2.31e-04199273358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL1R1 OLFML1 CNN2

2.31e-04199273c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRC CNN2 SYNE2

2.34e-04200273e642b3e25b2884b2bc6114683fa7ac39d6559bf8
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRC CNN2 SYNE2

2.34e-04200273bb05d2d10c924202f78fa1bd271f60cbbf224108
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PTPRC KANSL1 SYNE2

2.34e-0420027312f1685ce8f218433068e090c9d839cd5a1910bf
ToppCelllung-Type_I_Pneumocytes|lung / shred on tissue and cell subclass

PIAS4 KANSL1

1.12e-03822726023212a51f8b3e05e6c3dcf4e8fbf53ba696fb2
ToppCell(09)_Ionocytes-(3)_72hpi|(09)_Ionocytes / shred by cell type and Timepoint

CDC25A TLE4

2.00e-03110272fce7d5a0617fc664b657f5bb9abb290e7cc234cb
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-5|TCGA-Colorectal / Sample_Type by Project: Shred V9

FOXJ2 CATSPERB

2.26e-0311727284be9d9715de5db57460e592bf3a749742ee848f
Drugpicoprazole

MGAM IK

7.51e-064262CID000071223
DrugNF506

PTPRC CDC25A

1.25e-055262CID000477728
Drugfructose-1,6-diphosphate sodium salt

MGAM AMPD3 BAG6 MPI

2.48e-05151264CID000000718
DrugN-dodecylimidazole

MGAM MPI

2.62e-057262CID000078002
Drugguaijaverin

MGAM IK

2.62e-057262CID005317847
Drugfluorophenylalanine

RERE MPI

3.50e-058262CID000009465
Drugisobutanol

IK SOS1 MPI

4.78e-0562263CID000006560
Drug1,6-di-o-phosphonohexopyranose

MGAM BAG6 MPI

5.26e-0564263CID000000737
DrugMS-275; Down 200; 10uM; PC3; HT_HG-U133A

CDC25A SYNE2 WAC SOS1

5.96e-051892647074_DN
Drug17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A

FOXJ2 ALMS1 CDC25A MPI

6.34e-051922641638_DN
DrugOrlistat; Up 200; 10uM; PC3; HT_HG-U133A

PIAS4 AMPD3 RERE CDK10

6.34e-051922646388_UP
Drugmonensin; Down 200; 10.9uM; MCF7; HT_HG-U133A_EA

ALMS1 CDC25A CDK10 SOS1

6.73e-051952641105_DN
DrugMethoxy-6-harmalan [3589-73-9]; Down 200; 18.6uM; HL60; HG-U133A

MGAM AMPD3 RERE SOS1

6.73e-051952641743_DN
DrugColistin sulfate [1264-72-8]; Up 200; 3uM; PC3; HT_HG-U133A

PIAS4 IL1R1 CDK10 TLE4

6.86e-051962644212_UP
DrugDosulepin hydrochloride [897-15-4]; Up 200; 12uM; HL60; HG-U133A

CDC25A KLHL18 CDK10 MPI

6.86e-051962641713_UP
DrugTetramisole hydrochloride [16595-80-5]; Down 200; 16.6uM; MCF7; HT_HG-U133A

AMPD3 ALMS1 CDK10 TLE4

7.00e-051972642849_DN
DrugPHA-00846566E [724718-26-7]; Up 200; 10uM; PC3; HT_HG-U133A

RERE IL1R1 KLHL18 CDK10

7.00e-051972647046_UP
DrugNaftopidil dihydrochloride [57149-08-3]; Up 200; 8.6uM; MCF7; HT_HG-U133A

AMPD3 RERE CDC25A CDK10

7.14e-051982647331_UP
Drugphosphotyrosine (pY

RERE PTPRC SMURF2 SOS1

7.86e-05203264CID000030819
DrugNSC299933

MGAM AMPD3

9.71e-0513262CID000431902
DrugAC1L19WB

IK MPI

1.13e-0414262CID000000731
Drug7-aminocephalosporanic acid

AMPD3 SYNE2

1.13e-0414262ctd:C030735
Drugammonium heptamolybdate

PTPRC CDC25A

1.30e-0415262CID000025488
DrugMaleic Anhydrides

AMPD3 SYNE2

1.69e-0417262ctd:D008299
Drug2cgx

PTPRC BAG6

1.90e-0418262CID001548380
DrugCymarigenen

MGAM IK

2.35e-0420262CID000005303
DrugEpichlorohydrin

AMPD3 SYNE2

2.60e-0421262ctd:D004811
Drugd-sedoheptulose 1,7-diphosphate

MGAM BAG6

2.86e-0422262CID000001193
Drugdiphenylacetylene

AMPD3 MPI

2.86e-0422262CID000010390
Drugdolichols

MGAM IK MPI

3.57e-04122263CID000439223
Drugv 283 m

MGAM IK MPI

4.59e-04133263CID006449406
Drugarsenate

MGAM CDC25A MPI

4.80e-04135263CID000000233
Drugnitrate

MGAM RERE BAG6 WAC

5.09e-04331264CID000000943
Drugglyceraldehyde

AMPD3 BAG6 MPI

5.33e-04140263CID000000751
Drugiodomelatonin

RERE IK

5.35e-0430262CID000115348
DrugWaI

WAC MPI

6.09e-0432262CID000656967
Drugdihydroxyacetone phosphate

AMPD3 BAG6 MPI

6.91e-04153263CID000000668
Drugphosphoarginine

MGAM RERE

7.29e-0435262CID000092150
Drugcellobiitol

MGAM SOS1

8.15e-0437262CID000003871
Drugacrylyl-coenzyme A

MGAM BAG6

8.15e-0437262CID000439340
DrugAC1Q6S7E

BAG6 MPI

8.15e-0437262CID000000697
Drugallulose 6-phosphate

MGAM BAG6 MPI

8.15e-04162263CID000000603
Drugammonium hexachloroplatinate

AMPD3 SYNE2

9.05e-0439262ctd:C018453
Drugglycine

RERE IK BAG6

9.21e-04169263CID000000750
DrugAC1L1CRO

MGAM SYNE2

9.52e-0440262CID000002029
Drugp-fluorophenylalanine

SYNE2 MPI

9.52e-0440262CID000004654
Drugpsychotrine

IK BAG6

9.52e-0440262CID005462438
DrugNiclosamide [50-65-7]; Up 200; 12.2uM; HL60; HG-U133A

MGAM RERE IL1R1

9.69e-041722631998_UP
DrugAC1NDP1R

MGAM MPI

1.05e-0342262CID004629338
DrugG11459

RERE MPI

1.10e-0343262CID000472328
DrugChrysin [480-40-0]; Down 200; 15.8uM; HL60; HT_HG-U133A

AMPD3 ALMS1 CDK10

1.12e-031812633106_DN
Drug0179445-0000 [211246-22-9]; Down 200; 10uM; MCF7; HT_HG-U133A

ALMS1 CDC25A SOS1

1.14e-031822633630_DN
Diseaseneutrophil percentage of leukocytes

FOXJ2 AMPD3 RERE KANSL1 GLCCI1 CNN2 TLE4

9.67e-07610277EFO_0007990
Diseasewhite matter microstructure measurement

CATSPERB AMPD3 KANSL1 CDK10 SOS1

2.50e-05390275EFO_0005674
Diseaseeosinophil percentage of granulocytes

RERE PTPRC KANSL1 CNN2

5.86e-05234274EFO_0007996
Diseasebasophil count, eosinophil count

RERE PTPRC KANSL1 GLCCI1

6.57e-05241274EFO_0004842, EFO_0005090
Diseaseattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia

RERE IL1R1 CDK10

1.07e-04101273EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Diseasehousehold income

KANSL1 CDC25A GLCCI1 TLE4

1.61e-04304274EFO_0009695
Diseasewhite matter integrity

AMPD3 KANSL1 BAG6

2.26e-04130273EFO_0004641
Diseaseeosinophil count

RERE PTPRC KANSL1 IL1R1 GLCCI1 CNN2 WAC

2.98e-041488277EFO_0004842
Diseaselymphocyte percentage of leukocytes

RERE PTPRC KANSL1 GLCCI1 TLE4

3.06e-04665275EFO_0007993
Diseasebrain connectivity measurement

PIAS4 RERE KANSL1 SOS1

4.56e-04400274EFO_0005210
Diseasemean reticulocyte volume

FOXJ2 PTPRC KANSL1 BAG6 WAC

7.07e-04799275EFO_0010701
Diseaseschizophrenia, anorexia nervosa

RERE ALMS1

8.86e-0448272MONDO_0005090, MONDO_0005351
Diseaseneutrophil percentage of granulocytes

RERE PTPRC KANSL1

1.16e-03228273EFO_0007994
Diseasemyeloid white cell count

AMPD3 RERE PTPRC GLCCI1 CNN2

1.44e-03937275EFO_0007988
Diseasecutaneous melanoma, hair color

AMPD3 SYNE2

1.47e-0362272EFO_0000389, EFO_0003924
Diseaseplatelet crit

RERE PTPRC KANSL1 CNN2 TLE4

1.55e-03952275EFO_0007985
Diseasegranulocyte count

RERE GLCCI1 CNN2

1.58e-03254273EFO_0007987
Diseaseage-related macular degeneration, COVID-19

BAG6 CNN2

1.82e-0369272EFO_0001365, MONDO_0100096

Protein segments in the cluster

PeptideGeneStartEntry
YHADPSKPIPRNMFH

CATSPERB

886

Q9H7T0
PPRHLHVVRPMSHYT

BAG6

351

P46379
PYVDHQMRENHSPLP

ALMS1

2936

Q8TCU4
PRDPHVHYPSCMKDK

GLCCI1

186

Q86VQ1
KMLEHQEPHSLPYPD

AMPD3

236

Q01432
LNHPPYMPHLESRDR

MGAM

1441

O43451
PPVHDPNHSKMRLRD

KANSL1

776

Q7Z3B3
GYNRPAHHMVPRPSV

FOXJ2

541

Q9P0K8
PQHYPDANHKPEMAI

MPI

126

P34949
PHTHRGYQPTPAMAK

EPS8L2

481

Q9H6S3
FPKRPRSHSMIHYNP

OLFML1

361

Q6UWY5
LFPTMPRHNYHKVAP

FADS2B

426

A8MWK0
KDYHLMPERRPHLPA

KLHL18

261

O94889
EPELMPTFPHHRNKR

CDK10

331

Q15131
YHMPVQRRSPSSKHQ

IL1R1

536

P14778
CEPPSYRPMHHEDFK

CDC25A

481

P30304
VPDSPSCPEHHYKQM

SYNE2

6456

Q8WXH0
HRHEKMRDAGDPSPP

WAC

41

Q9BTA9
RPHVMSPTNRNHPFY

RERE

1261

Q9P2R6
PPKTYKREHTHPSMH

SOS1

1306

Q07889
YDPKNHILPPMDHST

CNN2

191

Q99439
YMSRTHLHTPPDLPE

SMURF2

241

Q9HAU4
SKMYPQTRHPAPHQP

TLE4

6

Q04727
PPSKSRHHEMPREYN

IK

51

Q13123
QPHRPLDPLTMHSTY

PIAS4

76

Q8N2W9
HPYLHNMKKRDPPSE

PTPRC

926

P08575
PSMNAAIPHVPRYHL

TTLL13

681

A6NNM8