Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

ARHGEF40 RAPGEF6 ARHGEF28 DOCK6 TAGAP

1.57e-05231285GO:0005085
GeneOntologyMolecularFunctionGTP-dependent protein binding

UNC13B RAPGEF6

5.13e-0424282GO:0030742
GeneOntologyMolecularFunctionenzyme regulator activity

DGKQ ARHGEF40 RAPGEF6 ARHGEF28 DOCK6 TAGAP NOS2 SOCS7

5.45e-041418288GO:0030234
GeneOntologyMolecularFunctionmonooxygenase activity

FMO5 NOS2 TPH1

5.49e-04115283GO:0004497
GeneOntologyMolecularFunctionGTPase regulator activity

ARHGEF40 RAPGEF6 ARHGEF28 DOCK6 TAGAP

6.27e-04507285GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

ARHGEF40 RAPGEF6 ARHGEF28 DOCK6 TAGAP

6.27e-04507285GO:0060589
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

FMO5 NOS2

1.43e-0340282GO:0016709
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

FMO5 NOS2 TPH1

2.47e-03194283GO:0016705
GeneOntologyMolecularFunctionNADP binding

FMO5 NOS2

3.40e-0362282GO:0050661
DomainC1_1

UNC13B DGKQ ARHGEF28

8.36e-0557283PF00130
DomainZF_DAG_PE_1

UNC13B DGKQ ARHGEF28

1.18e-0464283PS00479
DomainZF_DAG_PE_2

UNC13B DGKQ ARHGEF28

1.18e-0464283PS50081
DomainC1

UNC13B DGKQ ARHGEF28

1.24e-0465283SM00109
DomainPE/DAG-bd

UNC13B DGKQ ARHGEF28

1.30e-0466283IPR002219
DomainRA

DGKQ RAPGEF6

9.81e-0431282SM00314
DomainRA

DGKQ RAPGEF6

1.32e-0336282PF00788
DomainRA

DGKQ RAPGEF6

1.40e-0337282PS50200
DomainRA_dom

DGKQ RAPGEF6

1.63e-0340282IPR000159
DomainDH_1

ARHGEF40 ARHGEF28

4.00e-0363282PS00741
DomainDH_2

ARHGEF40 ARHGEF28

4.91e-0370282PS50010
DomainRhoGEF

ARHGEF40 ARHGEF28

4.91e-0370282PF00621
DomainDH-domain

ARHGEF40 ARHGEF28

5.05e-0371282IPR000219
Domain-

ARHGEF40 ARHGEF28

5.05e-03712821.20.900.10
DomainSH2

SOCS7 PTK6

9.99e-03101282PF00017
DomainSH2

SOCS7 PTK6

1.18e-02110282SM00252
DomainSH2

SOCS7 PTK6

1.20e-02111282PS50001
DomainSH2

SOCS7 PTK6

1.22e-02112282IPR000980
Domain-

SOCS7 PTK6

1.22e-021122823.30.505.10
Pubmed

Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes.

ADAMTS4 NOS2

3.75e-06428218050214
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

UNC13B DGKQ DDX56 ARHGEF40 RAPGEF6 MED13L DOCK6

2.11e-05110528735748872
Pubmed

Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.

DNHD1 ARHGEF40

8.44e-051728212693554
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

UNC13B RAPGEF6

2.86e-043128225838543
Pubmed

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

GPR179 SOCS7

3.05e-043228223535730
CytobandEnsembl 112 genes in cytogenetic band chr17q12

GPR179 SOCS7

3.74e-03149282chr17q12
GeneFamilySH2 domain containing

SOCS7 PTK6

4.46e-03101182741
CoexpressionFOSTER_TOLERANT_MACROPHAGE_DN

TOR1AIP2 MED13L ADAMTS4 TAGAP NOS2 SOCS7

4.44e-06418286M12676
CoexpressionFOSTER_TOLERANT_MACROPHAGE_DN

TOR1AIP2 MED13L ADAMTS4 TAGAP NOS2 SOCS7

5.58e-06435286MM1221
CoexpressionGSE32986_CURDLAN_HIGHDOSE_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_DN

TRIM69 MED13L TAGAP EHD1

5.83e-05200284M8631
CoexpressionGSE25890_CTRL_VS_IL33_IL7_TREATED_NUOCYTES_UP

UNC13B CADM3 FRMD4B GPR179

5.83e-05200284M7358
ToppCelldroplet-Lung-nan-21m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF28 ITPRID1 TPH1 ZNF575

5.13e-061842847cc3b9bba1f600b40b02fe2456b5d007dbf9fa37
ToppCelldroplet-Lung-nan-21m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF28 ITPRID1 TPH1 ZNF575

5.13e-0618428453b71c4ac86dc5e42763b8f64fbc917177531017
ToppCell10x5'v1-week_12-13-Endothelial-stroma-tip_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ARHGEF28 ADAMTS4 DOCK6 NOS2

5.95e-06191284cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCelldroplet-Lung-nan-3m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM3 SLC41A2 TMEM131L

1.16e-0415228377b319f594d5e4df29034bbf69c7490076f89dd3
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO5 GPR179 ZNF575

1.41e-04162283de0fde4310a56dc96bfc134c44d104993526d9bc
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CADM3 SLC41A2 TMEM131L

1.48e-04165283c39f0479955c4e23921f7a450d3bc251a002200f
ToppCelldroplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B NOS2 SOCS7

1.54e-04167283bad33497ceeab968a7eb8a48b921c6f936390743
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM131L DGKQ TAGAP

1.56e-04168283182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|Myeloid_cells / Location, Cell class and cell subclass

UNC13B DNHD1 ZNF575

1.59e-04169283dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCellPND10-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC41A2 KCNK6 PTK6

1.59e-04169283a83e4078db91ecedee637b28b12ec38640fe45f9
ToppCellPND10-Immune-Immune_Myeloid-DC-maDC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC41A2 KCNK6 PTK6

1.59e-04169283f914aa8899fa170a09da31e5fad86de897ea789b
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

UNC13B DNHD1 ZNF575

1.68e-04172283f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCellB_cells-pDCs|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SLC41A2 ADAMTS4 FRMD4B

1.79e-04176283ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

ITPRID1 DOCK6 NOS2

1.95e-04181283c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ARHGEF28 DOCK6 NOS2

1.98e-04182283997d37ca2af661c92a56add888762724dfccc890
ToppCelldroplet-Lung-21m-Epithelial-airway_epithelial-club_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITPRID1 TPH1 ZNF575

2.04e-041842839365cdc52a2419e3f27e1c1c9310fa707d1e506b
ToppCelldroplet-Lung-21m-Epithelial-airway_epithelial-club_cell-club_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITPRID1 TPH1 ZNF575

2.04e-04184283204d16c48f822c98dc4118ac97a4f99f7e1163c8
ToppCell3'_v3-blood-Myeloid_Dendritic-DC1|blood / Manually curated celltypes from each tissue

CADM3 SLC41A2 KCNK6

2.18e-04188283411d4dd5c9dee7ebd8db352640cf009e7b033ba9
ToppCell10x3'2.3-week_14-16-Myeloid_DC-DC-DC2|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SLC41A2 KCNK6 ARHGEF40

2.18e-0418828315d8dc514d5da46f6af284e7c1c92c606712dae6
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

UNC13B MED13L ITPRID1

2.18e-041882831aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCell5'-Adult-LymphNode-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM131L TRIM69 EDEM2

2.28e-04191283e5c41c3054ead03597c136eaccaf9822e6bb9d1a
ToppCell5'-Adult-LymphNode-Epithelial-goblet|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM131L TRIM69 EDEM2

2.28e-041912837e24175c7fabe5ea0b22b73173da4c3a666e5eb8
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

UNC13B FMO5 FRMD4B

2.35e-04193283738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UNC13B FMO5 FRMD4B

2.35e-04193283fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UNC13B FMO5 FRMD4B

2.35e-04193283f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellCV-Healthy-6|CV / Virus stimulation, Condition and Cluster

TRIM69 TAGAP EHD1

2.35e-041932831e285c31823d3e1a18d8c01748cc3604f400c954
ToppCellIPF-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

UNC13B ITPRID1 NOS2

2.39e-04194283777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCellCD8+_Memory_T_cell-CV-6|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

TRIM69 TAGAP EHD1

2.39e-0419428335a347c3824757b9de8b7f49db46e73e7fb63a4f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B FMO5 FRMD4B

2.39e-0419428397534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

UNC13B SLC41A2 ARHGEF28

2.50e-041972831a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

UNC13B SLC41A2 ARHGEF28

2.50e-041972831485933986921ff45669d9b7501c8d17050b3e97
ToppCellASK440-Epithelial-Type_2|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

UNC13B FMO5 FRMD4B

2.50e-0419728308d5bbeb77a4152af1c783bc958afcae24667767
ToppCellLPS_only-Epithelial_alveolar-AT_2|LPS_only / Treatment groups by lineage, cell group, cell type

UNC13B SLC41A2 ARHGEF28

2.54e-04198283d087e738d69ca9853553fde46d4e7a8906439d32
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B FMO5 FRMD4B

2.54e-041982832e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellmoderate-Myeloid-Neutrophil|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ARHGEF40 TAGAP EHD1

2.54e-04198283a6306dac34af5783f3a734ef1eaa7a0c03267b4f
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

UNC13B SLC41A2 ARHGEF28

2.54e-04198283aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

UNC13B SLC41A2 ARHGEF28

2.54e-04198283285f729140b1df029c24f6ca1d2438470ac51794
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B FMO5 FRMD4B

2.54e-04198283f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellFetal_29-31_weeks-Epithelial-club_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B SLC41A2 SOCS7

2.54e-041982835fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ARHGEF28 ADAMTS4 DOCK6

2.57e-041992831c69395c9305b6ecb0a826d46c8e8ec95795ad6d
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TMEM131L EHD1 ZNF575

2.57e-0419928326bb93347e6722abd174dfa62cab692ce2b7eb23
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

DNHD1 DDX56 RAPGEF6

2.57e-04199283fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

UNC13B SLC41A2 ARHGEF28

2.61e-04200283e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell10x5'v1-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ARHGEF28 ADAMTS4 DOCK6

2.61e-0420028377ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ARHGEF28 ADAMTS4 DOCK6

2.61e-04200283aafe594c88710f8c53d59667cdac5035e08f5511
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ARHGEF28 ADAMTS4 DOCK6

2.61e-04200283a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC41A2 ARHGEF28 ITPRID1

2.61e-042002830eb9ad8c0373bcc62029ec21c590ed03aaacd039
Drug7,8-Dihydro-L-Biopterin

NOS2 TPH1

1.46e-062282DB03271
Drugspinosin

NOS2 TPH1

8.74e-064282CID000155692
Drugswertisin

NOS2 TPH1

1.46e-055282CID000124034
DiseasePsoriasis

TAGAP NOS2

1.34e-0357282C0033860
DiseasePustulosis of Palms and Soles

TAGAP NOS2

1.34e-0357282C0030246
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

DGKQ DDX56 DOCK6

2.59e-03291283EFO_0008317, EFO_0020946
Diseaseceliac disease

TAGAP FRMD4B

6.36e-03126282EFO_0001060

Protein segments in the cluster

PeptideGeneStartEntry
NLPSPSEHKLPECHL

ARHGEF40

416

Q8TER5
DLLHAKLPPDSCPLL

DGKQ

576

P52824
PHLLHCPLLAPQLLD

DNHD1

896

Q96M86
PPHPREGQKLLLHCE

CADM3

241

Q8N126
DLHGLTELILLPPPC

KCNK6

261

Q9Y257
DVHLEPHLLIKPDPG

ARHGEF28

1251

Q8N1W1
GFHLPEDPSHPCILI

NOS2

966

P35228
LPSHCLLPLKIPDAC

MED13L

956

Q71F56
EKLIPHLHKLPGDPA

ITPRID1

661

Q6ZRS4
PEKPLCLLVHGPLDH

GPR179

2271

Q6PRD1
HDLPLHPAVVKPHLG

DDX56

476

Q9NY93
LLCALLPQHHGAPGP

EDEM2

11

Q9BV94
LAAPCRKHEPEPLPH

PTK6

166

Q13882
LDHDLPKKPGPTILH

FRMD4B

121

Q9Y2L6
GHCLLDKPEAPLHLP

ADAMTS4

421

O75173
NPHFCLSPELLHIKP

DOCK6

506

Q96HP0
DPKLALHLLLGPCTP

FMO5

456

P49326
KLEGHELPADLPPHL

EHD1

511

Q9H4M9
HHLPSENLGKEPLDP

TOR1AIP2

101

Q8NFQ8
LADLKEGPHTHLKPP

RAPGEF6

1516

Q8TEU7
HCLLPPLPPAHHVED

TAGAP

631

Q8N103
HHLLPLCADVVPGPS

TMEM131L

851

A2VDJ0
LHLHSIPGELPDEPK

SLC41A2

436

Q96JW4
LPLLKGHPQCPEHGE

TRIM69

106

Q86WT6
PEPDTCHELLGHVPL

TPH1

266

P17752
KLAAHRLCHDPPTAP

ZNF575

191

Q86XF7
HPPPDLVLQKDHFLG

UNC13B

341

O14795
HRCALDPKALPPGLA

SOCS7

31

O14512