Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainPH

PLEKHM2 OSBPL3 OBSCN PLD2 ARAP2

1.29e-03229665PF00169
DomainPH

PLEKHM2 OSBPL3 OBSCN PLD2 ARAP2

3.00e-03278665SM00233
DomainPH_DOMAIN

PLEKHM2 OSBPL3 OBSCN PLD2 ARAP2

3.05e-03279665PS50003
DomainPH_domain

PLEKHM2 OSBPL3 OBSCN PLD2 ARAP2

3.10e-03280665IPR001849
Domainzf-C2H2_6

ZNF506 ZNF808 ZNF208 ZNF682 ZNF574

5.03e-03314665PF13912
DomainZINC_FINGER_C2H2_2

ZNF506 ZNF808 ZNF208 ZC3H7B ZNF682 ZXDB ZNF222 ZNF574

5.81e-03775668PS50157
DomainZINC_FINGER_C2H2_1

ZNF506 ZNF808 ZNF208 ZC3H7B ZNF682 ZXDB ZNF222 ZNF574

5.90e-03777668PS00028
Domain-

TRANK1 ZC3H7B TRRAP EDRF1

6.18e-032076641.25.40.10
DomainZnf_C2H2-like

ZNF506 ZNF808 ZNF208 ZC3H7B ZNF682 ZXDB ZNF222 ZNF574

6.79e-03796668IPR015880
DomainZnf_C2H2

ZNF506 ZNF808 ZNF208 ZC3H7B ZNF682 ZXDB ZNF222 ZNF574

7.25e-03805668IPR007087
DomainZnF_C2H2

ZNF506 ZNF808 ZNF208 ZC3H7B ZNF682 ZXDB ZNF222 ZNF574

7.41e-03808668SM00355
DomainKRAB

ZNF506 ZNF808 ZNF208 ZNF682 ZNF222

8.65e-03358665PS50805
DomainKRAB

ZNF506 ZNF808 ZNF208 ZNF682 ZNF222

8.65e-03358665PF01352
Domain-

RNF113B ZC3H7B

8.80e-03406624.10.1000.10
DomainTPR-like_helical_dom

TRANK1 ZC3H7B TRRAP EDRF1

9.30e-03233664IPR011990
DomainKRAB

ZNF506 ZNF808 ZNF208 ZNF682 ZNF222

9.78e-03369665SM00349
DomainKRAB

ZNF506 ZNF808 ZNF208 ZNF682 ZNF222

9.89e-03370665IPR001909
Domain-

ZNF506 ZNF808 ZNF208 ZNF682 ZXDB ZNF222 ZNF574

9.89e-036796673.30.160.60
Pubmed

Unique charge-dependent constraint on collagen recognition by integrin α10β1.

COL2A1 ITGA10

3.88e-06269227569273
Pubmed

Leucine-rich repeats and immunoglobulin-like domains protein 1 and fascin actin-bundling protein 1 expression in nonsmall cell lung cancer.

LRIG1 FSCN1

3.88e-06269228230028
Pubmed

Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.

COL2A1 ITGA10 ABCC9

1.29e-052369325190801
Pubmed

BMP-2 and TGF-beta1 differentially control expression of type II procollagen and alpha 10 and alpha 11 integrins in mouse chondrocytes.

COL2A1 ITGA10

2.32e-05469220129696
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF506 ZNF208 ZNF682

2.63e-052969314563677
Pubmed

Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer.

SBNO1 TRRAP

3.86e-05569217308053
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

DNAJC13 OSBPL3 GEMIN8 TECR NAT10 WDR5 CPT1A TRRAP ZMYM4

4.43e-0584769935850772
Pubmed

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.

LRIG1 TM9SF4 PEX3

1.37e-045069324721909
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

THADA DNAJC13 EOGT TECPR2 TM9SF4 NAT10 OBSCN CPT1A TRRAP ZMYM4 RIC1

1.59e-041489691128611215
Pubmed

Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion.

WDR5 TRRAP

1.73e-041069220937768
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

SATB1 SBNO1 TECR NAT10 WDR5 TRRAP ZMYM4

2.04e-0460869736089195
Pubmed

Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes.

COL2A1 ITGA10

2.11e-041169215713743
Pubmed

Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2.

COL2A1 DMRTA2

2.11e-041169233707608
Pubmed

BMPR-II is dispensable for formation of the limb skeleton.

COL2A1 ACVR2A

2.53e-041269221538804
Pubmed

The DNA sequence and biology of human chromosome 19.

BSPH1 ZNF208 ZNF682 RYR1 ZNF222

2.57e-0428469515057824
Pubmed

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

TRRAP RPH3A

3.48e-041469228263302
Pubmed

Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.

WDR5 TRRAP

5.18e-041769221653943
Pubmed

New gene functions in megakaryopoiesis and platelet formation.

THADA SATB1 RPH3A

5.71e-048169322139419
Pubmed

USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.

WDR5 TRRAP

5.81e-041869217846119
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

LRIG1 PLEKHM2 OSBPL3 TM9SF4 PEX3 NAT10 TRRAP ARAP2 CYB561

7.58e-04124269930973865
Pubmed

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.

CYP7A1 CPT1A

8.73e-042269227146480
Pubmed

Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea.

COL2A1 ABCC9

9.55e-042369237873566
Pubmed

Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.

CYP7A1 CPT1A

9.55e-042369226508642
Pubmed

P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.

NAT10 TRRAP

1.13e-032569236708875
Pubmed

Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.

WDR5 TRRAP

1.32e-032769218838386
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

THADA PLEKHM2 OBSCN ZC3H7B TRRAP RIC1 RYR1 MVB12B

1.52e-03110569835748872
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

OSBPL3 PEX3 ZC3H7B RIC1 ZXDB ZNF574

1.84e-0365069638777146
Pubmed

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

WDR5 TRRAP ZMYM4

1.95e-0312469320850016
Cytoband19p12

CRLF1 ZNF208 ZNF682

3.48e-049069319p12
DrugBufexamac [2438-72-4]; Down 200; 18uM; HL60; HT_HG-U133A

DNAJC13 OSBPL3 TM9SF4 ACVR2A ZNF222 ARAP2 CYB561

2.16e-061966972382_DN
Diseasearterial stiffness measurement

SUSD5 ACVR2A RIC1

4.04e-0464663EFO_0004517
Diseaseuric acid measurement

DNAJC13 LRIG1 HBP1 TOP6BL ACVR2A AKR1B1 RPH3A

4.23e-04610667EFO_0004761
Diseasealcoholic hepatitis (biomarker_via_orthology)

CYP7A1 CPT1A

7.37e-0418662DOID:12351 (biomarker_via_orthology)
DiseasePseudoaphakia

COL2A1 AKR1B1

1.32e-0324662C0524524
DiseaseLens Opacities

COL2A1 AKR1B1

1.32e-0324662C1510497

Protein segments in the cluster

PeptideGeneStartEntry
KHLEKLKYCWGYEKS

EOGT

71

Q5NDL2
KVEGCYAKARLWFHS

CD53

166

P19397
YKHFVPWCKKSDVIS

COQ10B

101

Q9H8M1
YGDKDKRRHCFATWK

ACVR2A

51

P27037
KKKYVKGDVSLCRWH

FBXO34

636

Q9NWN3
IYLSGLHSWKKKFIR

CPT1A

31

P50416
KSLLHGRCYDRWFDK

CPT1A

441

P50416
GIKLLKLYAWEHIFC

ABCC9

501

O60706
LFYKDCHALDQWRKG

ARAP2

1021

Q8WZ64
KKGYADLYSLHSWCG

CYB561

111

P49447
LKSCSGHSYIRKNWL

CC2D2B

986

Q6DHV5
ALKGHKRYCRWKDCL

DMRTA2

81

Q96SC8
VSKLWCTYHEKGLVK

AKR1B1

76

P15121
WFADKFSFHLKGRKL

CLYBL

146

Q8N0X4
YTALKDGCTKHTGKW

COL2A1

1431

P02458
FAHYSLLTKKWKLFG

RIC1

516

Q4ADV7
TLHRLKFLGLSKKYW

GDAP1L1

276

Q96MZ0
KIWKDSKEYGHTFRS

PTCD3

511

Q96EY7
ACSYKGKKDNEWRLS

MB21D2

276

Q8IYB1
KLCAGSAYHKEPWKA

LRIG1

896

Q96JA1
LSFDKHCDRKQPKYW

GEMIN8

221

Q9NWZ8
KSNCTKEGHTYWLFK

EDRF1

411

Q3B7T1
WNFLKRHKKKCIFLG

PEX3

6

P56589
KKDAGRHRWGQFYKS

LHX4

216

Q969G2
LWCYKKELGFSSHRK

NAT10

56

Q9H0A0
WKDGLFKSKVTRYLC

MVB12B

81

Q9H7P6
EKKKLGTYTWIRCHE

OBSCN

551

Q5VST9
WATRAYSSHEDKKKC

PAPPA2

1191

Q9BXP8
DTKKCAFRTHTGKYW

FSCN1

301

Q16658
YYDCIKSKARHKWCS

BSPH1

56

Q075Z2
ACFYTTKHSWRGKYK

DNAJC13

11

O75165
TKHSWRGKYKRVFSV

DNAJC13

16

O75165
VFCLWKLGFFAHKKI

ITGA10

1141

O75578
CKLDHPFYVKNKGWS

HBP1

296

O60381
HKVLCHGKYFDWKKF

CYP7A1

86

P22680
YHKLALHWKLTKRKC

CHIC1

186

Q5VXU3
ELKQFLGWLKKHAYC

CRLF1

366

O75462
LGWLKKHAYCSNLSF

CRLF1

371

O75462
GGKYKTRLKQLLHWC

SBNO1

411

A3KN83
RKLFWGIFDSLAHKK

RYR1

2676

P21817
YLILWCFHLEAEKKG

CDC37L1

196

Q7L3B6
LKGWHKRFFYLDKGI

OSBPL3

66

Q9H4L5
KRHSWFKASGTIKKF

PARP6

156

Q2NL67
KAGTSYLGKEHWKTC

PLEKHM2

781

Q8IWE5
WGYRKCQHKSSVYKL

SUSD5

596

O60279
GFWTLRLCKKKGYVA

TRIM38

381

O00635
YLCKHLFCLLSKSGW

THADA

1846

Q6YHU6
KGERLKHWYECLKNK

RPH3A

661

Q9Y2J0
KDTSSLVDWKKYHLC

TOP6BL

271

Q8N6T0
CKFLHDRSDYKLGWE

RNF113B

211

Q8IZP6
CKEYKKGDKLLRHWA

RNF217

396

Q8TC41
AKCQEFGRWYKHFKK

SATB1

231

Q01826
CGWTFTTSYKLKRHL

ZXDB

311

P98169
YRTLKGHRWKKGAFC

TM9SF4

401

Q92544
DCGKSYRSFSNLWKH

ZNF574

826

Q6ZN55
CGKTFKWFSYLTKHK

ZNF682

206

O95780
CGKTFSYKSSLVWHR

ZNF808

656

Q8N4W9
WAKGKHRSYLKEFRD

TECR

281

Q9NZ01
CGKVTIKGKRHWYEA

TECPR2

876

O15040
CGKAYKWPSTLSYHK

ZNF208

866

O43345
CGKAYKWSSTLSYHK

ZNF208

1146

O43345
TGKTTCCLYRLWKKF

TRANK1

1036

O15050
AYGRCWHVLKKVKLG

VASH1

246

Q7L8A9
RHKSWGIDCLFEKLY

TPMT

226

P51580
LTHGDFSWTTKKKYR

PLD2

91

O14939
KVTHCCKSLWLKYSF

PXT1

21

Q8NFP0
CVLKYLGKTHNLWFR

TRRAP

2691

Q9Y4A5
WDYSKGKCLKTYTGH

WDR5

241

P61964
CGKTFTWYSSLSKHK

ZNF506

346

Q5JVG8
CKLLYKHDLAKRWGN

ZMYM4

756

Q5VZL5
KECGKSFKWSSYLLV

ZNF222

316

Q9UK12
KDLKYCSAKARHCWT

ZC3H7B

711

Q9UGR2
HGKCRKSFYWKAHLI

ZNF658B

146

Q4V348