Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF12 ZNF594 ZNF605 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 SRY NR5A1 ZNF658B ZNF471 RFXAP ZNF251 TBX5	9.60e-08	1412	54	17	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF12 ZNF594 ZNF605 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 SRY NR5A1 ZNF658B ZNF471 ZNF251 TBX5	1.04e-07	1244	54	16	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF12 ZNF594 ZNF605 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 SRY NR5A1 ZNF658B ZNF471 ZNF251 TBX5	1.39e-07	1271	54	16	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF12 ZNF594 ZNF605 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 SRY NR5A1 ZNF658B ZNF471 RFXAP ZNF251 TBX5	1.54e-07	1459	54	17	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF594 ZNF605 ZNF473 ZNF658 ZNF778 SRY ZNF658B RFXAP TBX5	1.74e-05	560	54	9	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF594 ZNF605 ZNF473 ZNF658 ZNF778 SRY ZNF658B RFXAP TBX5	1.89e-05	566	54	9	GO:0001216
GeneOntologyMolecularFunction	histone H3K36 trimethyltransferase activity	SETD2 ASH1L	7.14e-05	5	54	2	GO:0140955
GeneOntologyMolecularFunction	histone H3K36 methyltransferase activity	SETD2 ASH1L	5.49e-04	13	54	2	GO:0046975
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1C CACNA1E	6.40e-04	14	54	2	GO:0008331
Domain	KRAB	ZNF12 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZNF471 ZNF251	2.64e-09	358	51	11	PS50805
Domain	KRAB	ZNF12 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZNF471 ZNF251	2.64e-09	358	51	11	PF01352
Domain	KRAB	ZNF12 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZNF471 ZNF251	3.62e-09	369	51	11	SM00349
Domain	KRAB	ZNF12 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZNF471 ZNF251	3.73e-09	370	51	11	IPR001909
Domain	-	ZNF12 ZNF594 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 ZNF471 ZNF251	2.30e-08	679	51	13	3.30.160.60
Domain	zf-C2H2	ZNF12 ZNF594 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 ZNF471 ZNF251	2.93e-08	693	51	13	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF12 ZNF594 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 ZNF471 ZNF251	2.98e-08	694	51	13	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF12 ZNF594 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 ZNF471 ZNF251	1.08e-07	775	51	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF12 ZNF594 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 ZNF471 ZNF251	1.11e-07	777	51	13	PS00028
Domain	Znf_C2H2-like	ZNF12 ZNF594 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 ZNF471 ZNF251	1.47e-07	796	51	13	IPR015880
Domain	zf-C2H2_6	ZNF12 ZNF605 ZNF155 ZNF157 ZNF473 ZNF658 ZNF92 ZNF778 ZNF251	1.57e-07	314	51	9	PF13912
Domain	Znf_C2H2	ZNF12 ZNF594 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 ZNF471 ZNF251	1.68e-07	805	51	13	IPR007087
Domain	ZnF_C2H2	ZNF12 ZNF594 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 ZNF471 ZNF251	1.75e-07	808	51	13	SM00355
Domain	AWS	SETD2 ASH1L	7.27e-05	5	51	2	SM00570
Domain	AWS	SETD2 ASH1L	7.27e-05	5	51	2	PS51215
Domain	AWS_dom	SETD2 ASH1L	7.27e-05	5	51	2	IPR006560
Domain	VDCC_a1su_IQ	CACNA1C CACNA1E	1.52e-04	7	51	2	IPR014873
Domain	GPHH	CACNA1C CACNA1E	1.52e-04	7	51	2	PF16905
Domain	GPHH_dom	CACNA1C CACNA1E	1.52e-04	7	51	2	IPR031649
Domain	Ca_chan_IQ	CACNA1C CACNA1E	1.52e-04	7	51	2	SM01062
Domain	Ca_chan_IQ	CACNA1C CACNA1E	1.52e-04	7	51	2	PF08763
Domain	VDCCAlpha1	CACNA1C CACNA1E	3.24e-04	10	51	2	IPR002077
Domain	TIL	MUC19 MUC5B	4.74e-04	12	51	2	PF01826
Domain	C8	MUC19 MUC5B	4.74e-04	12	51	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC19 MUC5B	5.59e-04	13	51	2	IPR014853
Domain	C8	MUC19 MUC5B	5.59e-04	13	51	2	SM00832
Domain	TIL_dom	MUC19 MUC5B	6.51e-04	14	51	2	IPR002919
Domain	Post-SET_dom	SETD2 ASH1L	8.56e-04	16	51	2	IPR003616
Domain	VWD	MUC19 MUC5B	8.56e-04	16	51	2	SM00216
Domain	PostSET	SETD2 ASH1L	8.56e-04	16	51	2	SM00508
Domain	VWF_type-D	MUC19 MUC5B	8.56e-04	16	51	2	IPR001846
Domain	VWFD	MUC19 MUC5B	8.56e-04	16	51	2	PS51233
Domain	POST_SET	SETD2 ASH1L	8.56e-04	16	51	2	PS50868
Domain	VWD	MUC19 MUC5B	8.56e-04	16	51	2	PF00094
Domain	CTCK_1	MUC19 MUC5B	1.09e-03	18	51	2	PS01185
Domain	VWC_out	MUC19 MUC5B	1.21e-03	19	51	2	SM00215
Domain	CT	MUC19 MUC5B	1.63e-03	22	51	2	SM00041
Domain	Cys_knot_C	MUC19 MUC5B	2.11e-03	25	51	2	IPR006207
Domain	CTCK_2	MUC19 MUC5B	2.11e-03	25	51	2	PS01225
Domain	Laminin_EGF	LAMA2 MEGF11	4.11e-03	35	51	2	PF00053
Domain	EGF_Lam	LAMA2 MEGF11	4.11e-03	35	51	2	SM00180
Domain	VWC	MUC19 MUC5B	4.83e-03	38	51	2	SM00214
Domain	VWFC_2	MUC19 MUC5B	4.83e-03	38	51	2	PS50184
Domain	Laminin_EGF	LAMA2 MEGF11	4.83e-03	38	51	2	IPR002049
Domain	SET	SETD2 ASH1L	5.60e-03	41	51	2	PF00856
Domain	Disintegrin_dom	DUSP10 ADAM28	5.60e-03	41	51	2	IPR001762
Domain	VWF_dom	MUC19 MUC5B	5.87e-03	42	51	2	IPR001007
Domain	SET	SETD2 ASH1L	7.01e-03	46	51	2	SM00317
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF12 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 CGA ZNF778 ZFHX3 NR5A1 ZNF471 TBX5	2.79e-05	1387	42	14	M734
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1C CACNA1E	4.69e-04	11	42	2	M47958
Pathway	WP_HOMOLOGOUS_RECOMBINATION	BRCA2 RAD54B	5.61e-04	12	42	2	MM15951
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_TESTIS_DIFFERENTIATION	SRY NR5A1	6.62e-04	13	42	2	M41725
Pathway	WP_HOMOLOGOUS_RECOMBINATION	BRCA2 RAD54B	6.62e-04	13	42	2	M39712
Pathway	WP_SOMATIC_SEX_DETERMINATION	SRY NR5A1	7.71e-04	14	42	2	M39887
Pubmed	ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.	ZNRF3 SRY NR5A1	1.59e-06	15	54	3	29735715
Pubmed	Identification of novel SRY mutations and SF1 (NR5A1) changes in patients with pure gonadal dysgenesis and 46,XY karyotype.	SRY NR5A1	2.37e-06	2	54	2	21242195
Pubmed	Localization of the calcium channel subunits Cav1.2 (alpha1C) and Cav2.3 (alpha1E) in the mouse organ of Corti.	CACNA1C CACNA1E	2.37e-06	2	54	2	12973680
Pubmed	Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2.	SETD2 ASH1L	2.37e-06	2	54	2	26002201
Pubmed	SRY and NR5A1 gene mutation in Algerian children and adolescents with DSD and testicular dysgenesis.	SRY NR5A1	2.37e-06	2	54	2	35222615
Pubmed	A conserved NR5A1-responsive enhancer regulates SRY in testis-determination.	SRY NR5A1	2.37e-06	2	54	2	38555298
Pubmed	Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes.	CGA NR5A1	2.37e-06	2	54	2	12920232
Pubmed	The sequence of the human genome.	ZNF594 ZNF605 ZNRF3 ZNF658 RAD54B ZNF778 ZFHX3 CCDC168	4.02e-06	603	54	8	11181995
Pubmed	Role of Ahch in gonadal development and gametogenesis.	SRY NR5A1	7.09e-06	3	54	2	9843206
Pubmed	Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer.	SRY NR5A1	7.09e-06	3	54	2	18454134
Pubmed	Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations.	SRY NR5A1	7.09e-06	3	54	2	21412441
Pubmed	Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XY(POS) mice.	SRY NR5A1	1.42e-05	4	54	2	26194606
Pubmed	Molecular study and genotype-phenotype in Chinese female patients with 46, XY disorders of sex development.	SRY NR5A1	1.42e-05	4	54	2	34338568
Pubmed	Sex reversal caused by Mus musculus domesticus Y chromosomes linked to variant expression of the testis-determining gene Sry.	SRY NR5A1	1.42e-05	4	54	2	10588871
Pubmed	Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles.	LAMA2 MYBPC3	2.36e-05	5	54	2	10024132
Pubmed	The mouse Sry locus harbors a cryptic exon that is essential for male sex determination.	SRY NR5A1	2.36e-05	5	54	2	33004521
Pubmed	Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.	SETD2 ASH1L	2.36e-05	5	54	2	39390582
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1C CACNA1E	2.36e-05	5	54	2	15451373
Pubmed	Nonsyndromic 46,XX Testicular Disorders/Differences of Sex Development	SRY NR5A1	2.36e-05	5	54	2	20301589
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1C CACNA1E	2.36e-05	5	54	2	11296258
Pubmed	Functional analysis of Sox8 and Sox9 during sex determination in the mouse.	SRY NR5A1	2.36e-05	5	54	2	15056615
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC19 MUC5B	3.54e-05	6	54	2	19110483
Pubmed	Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases.	SETD2 ASH1L	3.54e-05	6	54	2	24019522
Pubmed	Wilms' tumor suppressor gene (WT1) as a target gene of SRY function in a mouse ES cell line transfected with SRY.	SRY NR5A1	3.54e-05	6	54	2	9879712
Pubmed	Sex reversal following deletion of a single distal enhancer of Sox9.	SRY NR5A1	3.54e-05	6	54	2	29903884
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1E	4.94e-05	7	54	2	12900400
Pubmed	Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice.	SRY NR5A1	4.94e-05	7	54	2	19269320
Pubmed	Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a.	SRY NR5A1	4.94e-05	7	54	2	24009392
Pubmed	Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9).	SRY NR5A1	6.59e-05	8	54	2	22294746
Pubmed	A subtractive gene expression screen suggests a role for vanin-1 in testis development in mice.	SRY NR5A1	6.59e-05	8	54	2	10951505
Pubmed	A cell-autonomous role for WT1 in regulating Sry in vivo.	SRY NR5A1	6.59e-05	8	54	2	19549635
Pubmed	Homozygous inactivation of Sox9 causes complete XY sex reversal in mice.	SRY NR5A1	6.59e-05	8	54	2	16207837
Pubmed	A census of human transcription factors: function, expression and evolution.	ZNF12 ZNF157 ZNF37A ASH1L ZFHX3 SRY NR5A1 TBX5	7.52e-05	908	54	8	19274049
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1C CACNA1E	8.46e-05	9	54	2	16382099
Pubmed	The transcription co-factor CITED2 functions during sex determination and early gonad development.	SRY NR5A1	8.46e-05	9	54	2	19457926
Pubmed	Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.	CACNA1C ZFHX3	8.46e-05	9	54	2	21042317
Pubmed	CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice.	SRY NR5A1	8.46e-05	9	54	2	37155872
Pubmed	Cbx2, a polycomb group gene, is required for Sry gene expression in mice.	SRY NR5A1	1.06e-04	10	54	2	22186409
Pubmed	Wnt4 is required for proper male as well as female sexual development.	SRY NR5A1	1.06e-04	10	54	2	15581876
Pubmed	Nonsyndromic Disorders of Testicular Development Overview	SRY NR5A1	1.06e-04	10	54	2	20301714
Pubmed	Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells.	CGA NR5A1	1.06e-04	10	54	2	35957608
Pubmed	Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse.	SRY NR5A1	1.29e-04	11	54	2	36912416
Pubmed	The DNA sequence and analysis of human chromosome 13.	BRCA2 MYCBP2 CCDC168 BORA	1.44e-04	170	54	4	15057823
Pubmed	Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.	SRY NR5A1	1.55e-04	12	54	2	28949961
Pubmed	Fetal testis dysgenesis and compromised Leydig cell function in Tgfbr3 (beta glycan) knockout mice.	SRY NR5A1	2.13e-04	14	54	2	19696014
Pubmed	Tpit-independent function of NeuroD1(BETA2) in pituitary corticotroph differentiation.	CGA NR5A1	2.13e-04	14	54	2	14726486
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1C CACNA1E	2.45e-04	15	54	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1C CACNA1E	2.45e-04	15	54	2	24453333
Pubmed	Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.	SRY NR5A1	2.45e-04	15	54	2	12223418
Pubmed	Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch.	ZFHX3 MEGF11	2.45e-04	15	54	2	31812516
Pubmed	TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.	SRY NR5A1	2.45e-04	15	54	2	31530896
Pubmed	Embryonic gonadotropin-releasing hormone signaling is necessary for maturation of the male reproductive axis.	CGA NR5A1	2.80e-04	16	54	2	20805495
Pubmed	A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.	TBX5 MYBPC3	3.17e-04	17	54	2	11572777
Pubmed	Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.	SRY NR5A1	3.17e-04	17	54	2	19753101
Pubmed	ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism.	CGA NR5A1	3.17e-04	17	54	2	26296153
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC19 MUC5B	3.56e-04	18	54	2	18834073
Pubmed	Loss of NEDD4 causes complete XY gonadal sex reversal in mice.	SRY NR5A1	3.56e-04	18	54	2	35075134
Pubmed	Foxh1 is essential for development of the anterior heart field.	TBX5 MYBPC3	3.56e-04	18	54	2	15363409
Pubmed	Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression.	SRY NR5A1	3.56e-04	18	54	2	23102580
Pubmed	Mouse Gonad Development in the Absence of the Pro-Ovary Factor WNT4 and the Pro-Testis Factor SOX9.	SRY NR5A1	3.98e-04	19	54	2	32365547
Pubmed	Tpit determines alternate fates during pituitary cell differentiation.	CGA NR5A1	3.98e-04	19	54	2	12651892
Pubmed	Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads.	SRY NR5A1	3.98e-04	19	54	2	30212841
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZNF12 ZNF473 BRCA2 ZNF92 ASH1L NR5A1 RFXAP	4.00e-04	877	54	7	20211142
Pubmed	Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia.	CGA NR5A1	4.42e-04	20	54	2	12183375
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SFMBT1 FAM193A BRCA2 MYCBP2 ZFHX3	4.77e-04	418	54	5	34709266
Pubmed	NRG1 signalling regulates the establishment of Sertoli cell stock in the mouse testis.	SRY NR5A1	4.88e-04	21	54	2	30040984
Pubmed	ETAA1 acts at stalled replication forks to maintain genome integrity.	BRCA2 ETAA1	4.88e-04	21	54	2	27723720
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF12 ZNF594	4.88e-04	21	54	2	7865130
Pubmed	Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types.	CGA NR5A1	4.88e-04	21	54	2	10367888
Pubmed	Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.	SRY NR5A1	4.88e-04	21	54	2	23300469
Pubmed	WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.	SRY NR5A1	5.36e-04	22	54	2	23095882
Pubmed	Gene-environment interaction impacts on heart development and embryo survival.	CACNA1C TBX5	5.36e-04	22	54	2	30787001
Pubmed	Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.	SRY NR5A1	5.36e-04	22	54	2	23987514
Pubmed	Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development.	CGA NR5A1	5.86e-04	23	54	2	10588713
Pubmed	Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells.	CGA NR5A1	6.39e-04	24	54	2	19139274
Pubmed	Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation.	TBX5 MYBPC3	6.39e-04	24	54	2	34062094
Pubmed	GADD45G functions in male sex determination by promoting p38 signaling and Sry expression.	SRY NR5A1	6.39e-04	24	54	2	23102581
Pubmed	The transcription factor GATA4 is required for follicular development and normal ovarian function.	CGA NR5A1	7.51e-04	26	54	2	23769843
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ACTR8 ZNF605 ZNF473 MYCBP2 ZNF92 IFT81 ASH1L ZNF251	7.80e-04	1285	54	8	35914814
Pubmed	Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.	BRCA2 RAD54B	8.10e-04	27	54	2	20610542
Pubmed	Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice.	SRY NR5A1	8.10e-04	27	54	2	35704566
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	ASH1L MUC19 CCDC168	9.39e-04	123	54	3	26912792
Pubmed	Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors.	CGA NR5A1	1.00e-03	30	54	2	32453714
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF12 ZNF37A	1.07e-03	31	54	2	2288909
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	BRCA2 RAD54B	1.07e-03	31	54	2	19690177
Pubmed	Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.	CACNA1E MYCBP2	1.07e-03	31	54	2	27321927
Pubmed	Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.	TBX5 MYBPC3	1.07e-03	31	54	2	17473172
Pubmed	Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.	CGA NR5A1	1.07e-03	31	54	2	18775421
Pubmed	Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans.	CGA NR5A1	1.14e-03	32	54	2	33795686
Pubmed	PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression.	CGA NR5A1	1.14e-03	32	54	2	31913463
Pubmed	Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development.	CGA TBX5	1.21e-03	33	54	2	10049363
Pubmed	Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice.	SRY NR5A1	1.29e-03	34	54	2	23300479
Pubmed	SOX2 regulates the hypothalamic-pituitary axis at multiple levels.	CGA NR5A1	1.36e-03	35	54	2	22945632
Pubmed	Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells.	SRY NR5A1	1.44e-03	36	54	2	15944188
Pubmed	MicroRNA-7a2 is Required for the Development of Pituitary Stem Cells.	CGA NR5A1	1.52e-03	37	54	2	35652338
Interaction	LTBP2 interactions	ZNF12 ZNF594 ZNF92 ZNF778 ZNF251	3.19e-06	85	54	5	int:LTBP2
Interaction	RAD51 interactions	SETD2 MMS22L ACTR8 BRCA2 MYCBP2 RAD54B TRIM36	3.52e-06	241	54	7	int:RAD51
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF12 ZNF594 ZNF605 ZNF155 ZNF157 ZNF473 ZNF37A ZNF658 ZNF92 ZNF778 ZFHX3 ZNF471 ZNF251	5.45e-10	718	36	13	28
GeneFamily	CD molecules\|Mucins	MUC19 MUC5B	7.90e-04	21	36	2	648
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1E	1.22e-03	26	36	2	253
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD2 ASH1L	2.08e-03	34	36	2	487
Drug	Androsterone [53-41-8]; Down 200; 13.8uM; PC3; HT_HG-U133A	SPAM1 BRCA2 CGA ASH1L ZFHX3 PRR14L	7.53e-06	199	54	6	4635_DN
Drug	Spiramycin [8025-81-8]; Up 200; 4.8uM; HL60; HT_HG-U133A	SETD2 SPAM1 ZNF155 PKP4 RAD54B LAMA2	7.75e-06	200	54	6	2558_UP
Disease	Ovotesticular Disorders of Sex Development	SRY NR5A1	8.78e-06	3	51	2	C2748895
Disease	True Hermaphroditism (disorder)	SRY NR5A1	8.78e-06	3	51	2	C0266361
Disease	Pure gonadal dysgenesis 46,XY	SRY NR5A1	4.37e-05	6	51	2	cv:C2936694
Disease	Swyer Syndrome	SRY NR5A1	6.12e-05	7	51	2	C2936694
Disease	Gonadal Dysgenesis, 46,XY	SRY NR5A1	8.15e-05	8	51	2	C0018054
Disease	Sudden Cardiac Death	CACNA1C MYBPC3	8.15e-05	8	51	2	C0085298
Disease	lung adenocarcinoma (is_implicated_in)	SETD2 ZFHX3 ADAM28	8.47e-05	49	51	3	DOID:3910 (is_implicated_in)
Disease	idiopathic pulmonary fibrosis (is_implicated_in)	SETD2 MUC5B	1.05e-04	9	51	2	DOID:0050156 (is_implicated_in)
Disease	Malignant tumor of prostate	BRCA2 ZFHX3	1.05e-04	9	51	2	cv:C0376358
Disease	liver cancer (is_marker_for)	SETD2 ADAM28	1.05e-04	9	51	2	DOID:3571 (is_marker_for)
Disease	colorectal cancer (is_marker_for)	SETD2 BRCA2 ZFHX3 ADAM28	1.59e-04	157	51	4	DOID:9256 (is_marker_for)
Disease	46,XY partial gonadal dysgenesis	SRY NR5A1	1.59e-04	11	51	2	C4510744
Disease	mean arterial pressure	MMS22L ZNRF3 IFT81 PKP4 ZFHX3 TRIM36	2.15e-04	499	51	6	EFO_0006340
Disease	cognitive function measurement, self reported educational attainment	SFMBT1 CACNA1E MMS22L FAM193A MYCBP2	3.66e-04	355	51	5	EFO_0004784, EFO_0008354
Disease	sphingomyelin 14:0 measurement	WDR89 ZFHX3	3.92e-04	17	51	2	EFO_0010390
Disease	Pancreatic Neoplasm	BRCA2 ZNRF3 ETAA1	6.99e-04	100	51	3	C0030297
Disease	Malignant neoplasm of pancreas	BRCA2 ZNRF3 ETAA1	7.40e-04	102	51	3	C0346647
Disease	Neoplasm of the genitourinary tract	BRCA2 ZFHX3	7.89e-04	24	51	2	cv:C0042065
Disease	intelligence, self reported educational attainment	MMS22L FAM193A TRIM36	1.10e-03	117	51	3	EFO_0004337, EFO_0004784
Disease	Antihypertensive use measurement	CACNA1C ZNRF3 PKP4 TRIM36	1.14e-03	265	51	4	EFO_0009927
Disease	cytokine measurement	CACNA1E MMS22L MYCBP2 LAMA2 TBX5	1.18e-03	461	51	5	EFO_0004873
Disease	cardiac arrhythmia	ZFHX3 TBX5	1.24e-03	30	51	2	EFO_0004269
Disease	Abnormality of radial ray	BRCA2 TBX5	1.49e-03	33	51	2	C4228778

Protein segments in the cluster

Peptide	Gene	Start	Entry
TSDYDSKTVENCVCT	PKP4	731	Q99569
YEATTCNCKKPDDDT	ASH1L	2091	Q9NR48
FYCTDSSKDTEKECI	CACNA1E	1316	Q15878
ECVDIEKAYKSTNCS	ADAM28	616	Q9UKQ2
CCSSDDTKKKMYSSI	ACTR8	521	Q9H981
STSTSTNQKEGKYCD	FAM193A	776	P78312
DCSYVLSKKCADSSF	MUC5B	446	Q9HC84
ECSSTCDKNEEKSLY	RAD54B	606	Q9Y620
FKDYMKESVCSSSTC	MEGF11	921	A6BM72
CCDKQDQELYKSSSS	MMS22L	466	Q6ZRQ5
FVSYDSSVTCDKTCK	SMPDL3A	411	Q92484
SSASCCTVATYDKDN	DUSP10	76	Q9Y6W6
EECKKYTCTCENSQD	MUC19	1031	Q7Z5P9
YDTTTDNKCSIKTAV	EVPL	1831	Q92817
TTCDSETKKCSCSDQ	LAMA2	1116	P24043
CVTSCTKEPETSNKY	ETAA1	356	Q9NY74
SGTCECFQKTYTSTK	PLIN1	31	O60240
NVTSESTCCVAKSYN	CGA	76	P01215
LTQECDEKKSQYDSC	IFT81	521	Q8WYA0
YTCSDSSKQTEAECK	CACNA1C	1076	Q13936
EDTTVKKSTNCAYDR	DNASE1L3	221	Q13609
KTNIEVCSTYSKDSE	BRCA2	2206	P51587
SYCKESDAQTCEVES	BORA	516	Q6PGQ7
KSVVSNSCKEMSCYS	FMO1	56	Q01740
SCYSTLSCKEKADVK	SPAM1	436	P38567
TQKTQTDCKCTADSE	CCDC168	1266	Q8NDH2
SVEKSSCKVSYTSQE	PRR14L	841	Q5THK1
HYTCTESQSCKIDKT	NR5A1	46	Q13285
ESTKSCMDCSASYCN	TRIM36	166	Q9NQ86
YHCTKRKEEECSTTD	TBX5	321	Q99593
YKTCTSKTEVTNSDE	SHOC1	531	Q5VXU9
DADCQEYAKIACSKT	MYCBP2	4376	O75592
CTYEGCSETTSQVAK	RFXAP	141	O00287
YECNECGKSFSEKST	ZNF37A	411	P17032
CLTTTDSKIFQCDKY	ZNF92	136	Q03936
YECTECGKTFSEKAT	ZNF157	246	P51786
YECKDCGKTFTVSSS	ZNF778	561	Q96MU6
SSYSKSDRDCKTETS	SETD2	486	Q9BYW2
CKTKDSDIYCTLNDS	SETD2	786	Q9BYW2
ECSECGKTFSEKSYV	ZNF658	911	Q5TYW1
YKCTECGKAFSDSSS	ZNF471	571	Q9BX82
CDICSKTFKYNSDLS	ZNF251	211	Q9BRH9
SSSSTSDCAICLEKY	ZNRF3	286	Q9ULT6
SEEKSYTCDECGKSI	ZNF155	171	Q12901
TYECKECEKTFNRSS	ZNF594	126	Q96JF6
DKCSENCSVLTKTKY	SFMBT1	621	Q9UHJ3
SSSFLCTESCNSKYQ	SRY	31	Q05066
DSCEKCLTSVSEYIS	ZNF12	141	P17014
SCDSVYSACTDGTVK	WDR89	81	Q96FK6
KYCDCSTCRKSSNEE	ZNF605	141	Q86T29
QKTHTDSKSYNCNEC	ZNF473	311	Q8WTR7
SKEVTCNECSASFAS	ZFHX3	76	Q15911
ECSECGKTFSEKSYV	ZNF658B	671	Q4V348
YEQCSKSTSEISKDC	WNK3	106	Q9BYP7
SYRCEVSTKDKFDCS	MYBPC3	236	Q14896