Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cell-cell junction	CNKSR1 SPTBN2 LAMA3 MPDZ NPHP4 CCDC85A CASK MPP4 PRKCG PRKCH PLCG1 EPHA5 PDZD2 TJP3	1.92e-05	591	130	14	GO:0005911
HumanPheno	Aplasia/Hypoplasia of the bladder	LAMA3 GRIP1 FREM2 PLEC	1.26e-05	16	49	4	HP:0010476
Domain	-	CNKSR1 MAGIX APBA1 MPDZ APBA3 CASK GRIP1 MPP4 PDZRN3 AHNAK2 PDZD2 TJP3	4.93e-10	150	128	12	2.30.42.10
Domain	PDZ	CNKSR1 MAGIX APBA1 MPDZ APBA3 CASK GRIP1 MPP4 PDZRN3 AHNAK2 PDZD2 TJP3	5.32e-10	151	128	12	PS50106
Domain	PDZ	CNKSR1 MAGIX APBA1 MPDZ APBA3 CASK GRIP1 MPP4 PDZRN3 AHNAK2 PDZD2 TJP3	5.75e-10	152	128	12	IPR001478
Domain	PDZ	MAGIX APBA1 MPDZ APBA3 CASK GRIP1 MPP4 PDZRN3 AHNAK2 PDZD2 TJP3	3.51e-09	141	128	11	PF00595
Domain	PDZ	MAGIX APBA1 MPDZ APBA3 CASK GRIP1 MPP4 PDZRN3 AHNAK2 PDZD2 TJP3	5.86e-09	148	128	11	SM00228
Domain	-	LRFN1 LINGO3 FBXL5 LRRC47 LRFN2 PXDN AMIGO3 SLIT3 LGR6 RTN4RL2 PPP1R42 LRRC75A NLRP5	3.23e-07	321	128	13	3.80.10.10
Domain	Leu-rich_rpt	LRFN1 LINGO3 FBXL5 LRRC47 LRFN2 PXDN AMIGO3 SLIT3 LGR6 RTN4RL2 PPP1R42 NLRP5	3.64e-07	271	128	12	IPR001611
Domain	L_dom-like	LRFN1 LINGO3 FBXL5 LRRC47 LRFN2 PXDN AMIGO3 SLIT3 LGR6 RTN4RL2 PPP1R42 LRRC75A NLRP5	4.12e-07	328	128	13	IPR032675
Domain	LRR_1	LINGO3 FBXL5 LRRC47 LRFN2 PXDN AMIGO3 SLIT3 LGR6 RTN4RL2 PPP1R42	2.72e-06	219	128	10	PF00560
Domain	LRR_8	LRFN1 LINGO3 LRRC47 LRFN2 PXDN AMIGO3 SLIT3 LGR6 RTN4RL2	2.75e-06	171	128	9	PF13855
Domain	LRR_TYP	LRFN1 LINGO3 LRRC47 LRFN2 PXDN AMIGO3 SLIT3 LGR6 RTN4RL2	3.65e-06	177	128	9	SM00369
Domain	Leu-rich_rpt_typical-subtyp	LRFN1 LINGO3 LRRC47 LRFN2 PXDN AMIGO3 SLIT3 LGR6 RTN4RL2	3.65e-06	177	128	9	IPR003591
Domain	LRRNT	LINGO3 LRFN2 PXDN AMIGO3 SLIT3 LGR6 RTN4RL2	4.97e-06	98	128	7	IPR000372
Domain	LRRNT	LINGO3 LRFN2 PXDN AMIGO3 SLIT3 LGR6 RTN4RL2	4.97e-06	98	128	7	SM00013
Domain	LRR	LRFN1 LINGO3 LRRC47 LRFN2 PXDN AMIGO3 SLIT3 LGR6 PPP1R42	1.02e-05	201	128	9	PS51450
Domain	Cys-rich_flank_reg_C	LRFN1 LINGO3 LRFN2 PXDN SLIT3 RTN4RL2	3.58e-05	90	128	6	IPR000483
Domain	LRRCT	LRFN1 LINGO3 LRFN2 PXDN SLIT3 RTN4RL2	3.58e-05	90	128	6	SM00082
Domain	Med13_N	MED13L MED13	4.66e-05	2	128	2	PF11597
Domain	Mediator_Med13_N_met/fun	MED13L MED13	4.66e-05	2	128	2	IPR021643
Domain	Med13_C	MED13L MED13	4.66e-05	2	128	2	PF06333
Domain	Mediator_Med13	MED13L MED13	4.66e-05	2	128	2	IPR009401
Domain	L27	MPDZ CASK MPP4	8.55e-05	13	128	3	SM00569
Domain	L27	MPDZ CASK MPP4	8.55e-05	13	128	3	PS51022
Domain	L27_dom	MPDZ CASK MPP4	8.55e-05	13	128	3	IPR004172
Domain	SAM_1	CNKSR1 ANKS1B PPFIA3 EPHA10 EPHA5	1.03e-04	68	128	5	PF00536
Domain	-	LRFN1 HLA-DQB2 RBPJL HAPLN2 LINGO3 PKHD1L1 LRFN2 PXDN AMIGO3 PKHD1 ALPK2 EPHA10 LILRA4 EPHA5	1.83e-04	663	128	14	2.60.40.10
Domain	G8_domain	PKHD1L1 PKHD1	2.77e-04	4	128	2	IPR019316
Domain	G8	PKHD1L1 PKHD1	2.77e-04	4	128	2	PS51484
Domain	G8	PKHD1L1 PKHD1	2.77e-04	4	128	2	SM01225
Domain	G8	PKHD1L1 PKHD1	2.77e-04	4	128	2	PF10162
Domain	SAM	CNKSR1 ANKS1B PPFIA3 EPHA10 EPHA5	3.48e-04	88	128	5	SM00454
Domain	Ig-like_fold	LRFN1 HLA-DQB2 RBPJL HAPLN2 LINGO3 PKHD1L1 LRFN2 PXDN AMIGO3 PKHD1 ALPK2 EPHA10 LILRA4 EPHA5	3.48e-04	706	128	14	IPR013783
Domain	LRRNT	LINGO3 AMIGO3 SLIT3 LGR6	4.75e-04	53	128	4	PF01462
Domain	SAM_DOMAIN	CNKSR1 ANKS1B PPFIA3 EPHA10 EPHA5	4.95e-04	95	128	5	PS50105
Domain	ACTININ_2	SPTBN2 SPTBN5 PLEC	5.04e-04	23	128	3	PS00020
Domain	ACTININ_1	SPTBN2 SPTBN5 PLEC	5.04e-04	23	128	3	PS00019
Domain	Actinin_actin-bd_CS	SPTBN2 SPTBN5 PLEC	5.04e-04	23	128	3	IPR001589
Domain	GUANYLATE_KINASE_2	CASK MPP4 TJP3	5.04e-04	23	128	3	PS50052
Domain	GUANYLATE_KINASE_1	CASK MPP4 TJP3	5.04e-04	23	128	3	PS00856
Domain	SAM	CNKSR1 ANKS1B PPFIA3 EPHA10 EPHA5	5.44e-04	97	128	5	IPR001660
Domain	RIH_assoc-dom	RYR2 ITPR2	6.87e-04	6	128	2	IPR013662
Domain	PbH1	PKHD1L1 PKHD1	6.87e-04	6	128	2	SM00710
Domain	Ins145_P3_rec	RYR2 ITPR2	6.87e-04	6	128	2	PF08709
Domain	RIH_assoc	RYR2 ITPR2	6.87e-04	6	128	2	PF08454
Domain	RIH_dom	RYR2 ITPR2	6.87e-04	6	128	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 ITPR2	6.87e-04	6	128	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 ITPR2	6.87e-04	6	128	2	IPR015925
Domain	-	RYR2 ITPR2	6.87e-04	6	128	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 ITPR2	6.87e-04	6	128	2	PF01365
Domain	PbH1	PKHD1L1 PKHD1	6.87e-04	6	128	2	IPR006626
Domain	Guanylate_kin	CASK MPP4 TJP3	7.28e-04	26	128	3	PF00625
Domain	GK/Ca_channel_bsu	CASK MPP4 TJP3	7.28e-04	26	128	3	IPR008145
Domain	Guanylate_kin-like_dom	CASK MPP4 TJP3	7.28e-04	26	128	3	IPR008144
Domain	GuKc	CASK MPP4 TJP3	7.28e-04	26	128	3	SM00072
Domain	-	CNKSR1 ANKS1B PPFIA3 EPHA10 EPHA5	8.15e-04	106	128	5	1.10.150.50
Domain	PID	APBA1 ANKS1B APBA3	9.09e-04	28	128	3	PF00640
Domain	Spectrin_repeat	SPTBN2 SPTBN5 PLEC	1.01e-03	29	128	3	IPR002017
Domain	IGc2	LRFN1 LINGO3 LRFN2 PXDN AMIGO3 ALPK2 LILRA4	1.19e-03	235	128	7	SM00408
Domain	Ig_sub2	LRFN1 LINGO3 LRFN2 PXDN AMIGO3 ALPK2 LILRA4	1.19e-03	235	128	7	IPR003598
Domain	TIG	RBPJL PKHD1L1 PKHD1	1.23e-03	31	128	3	PF01833
Domain	SAM/pointed	CNKSR1 ANKS1B PPFIA3 EPHA10 EPHA5	1.27e-03	117	128	5	IPR013761
Domain	Pectin_lyase_fold/virulence	PKHD1L1 PKHD1	1.27e-03	8	128	2	IPR011050
Domain	IPT	RBPJL PKHD1L1 PKHD1	1.35e-03	32	128	3	IPR002909
Domain	PID	APBA1 ANKS1B APBA3	1.35e-03	32	128	3	PS01179
Domain	SPEC	SPTBN2 SPTBN5 PLEC	1.35e-03	32	128	3	SM00150
Domain	Spectrin/alpha-actinin	SPTBN2 SPTBN5 PLEC	1.35e-03	32	128	3	IPR018159
Domain	PH_dom-spectrin-type	SPTBN2 SPTBN5	1.63e-03	9	128	2	IPR001605
Domain	MIR	RYR2 ITPR2	2.02e-03	10	128	2	PF02815
Domain	L27_C	CASK MPP4	2.02e-03	10	128	2	IPR014775
Domain	MIR_motif	RYR2 ITPR2	2.02e-03	10	128	2	IPR016093
Domain	L27	CASK MPP4	2.02e-03	10	128	2	PF02828
Domain	MIR	RYR2 ITPR2	2.02e-03	10	128	2	PS50919
Domain	MIR	RYR2 ITPR2	2.02e-03	10	128	2	SM00472
Domain	C2	UNC13D PRKCG PRKCH PLCG1 SYT13	2.09e-03	131	128	5	PF00168
Domain	EGF-like_CS	LAMA3 SLIT3 TENM1 LRP2 FBN3 EPHA10 EPHA5	2.16e-03	261	128	7	IPR013032
Domain	EGF_2	LAMA3 SLIT3 TENM1 LRP2 FBN3 EPHA10 EPHA5	2.36e-03	265	128	7	PS01186
Domain	C2	UNC13D PRKCG PRKCH PLCG1 SYT13	2.54e-03	137	128	5	SM00239
Domain	PTB	APBA1 ANKS1B APBA3	2.58e-03	40	128	3	SM00462
Domain	PTB/PI_dom	APBA1 ANKS1B APBA3	2.77e-03	41	128	3	IPR006020
Domain	Mab-21	MAB21L4 MIEF2	2.94e-03	12	128	2	PF03281
Domain	Mab-21	MAB21L4 MIEF2	2.94e-03	12	128	2	SM01265
Domain	Mab-21_dom	MAB21L4 MIEF2	2.94e-03	12	128	2	IPR024810
Domain	C2	UNC13D PRKCG PRKCH PLCG1 SYT13	2.96e-03	142	128	5	PS50004
Domain	LamG	COL15A1 LAMA3 SLIT3	3.39e-03	44	128	3	SM00282
Domain	-	UNC13D PRKCG PRKCH PLCG1 SYT13	3.54e-03	148	128	5	2.60.40.150
Domain	RECEPTOR_TYR_KIN_V_2	EPHA10 EPHA5	4.02e-03	14	128	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHA10 EPHA5	4.02e-03	14	128	2	PS00790
Domain	Tyr_kinase_rcpt_V_CS	EPHA10 EPHA5	4.02e-03	14	128	2	IPR001426
Domain	EphA2_TM	EPHA10 EPHA5	4.02e-03	14	128	2	PF14575
Domain	Ephrin_rcpt_lig-bd_dom	EPHA10 EPHA5	4.02e-03	14	128	2	IPR001090
Domain	Eph_TM	EPHA10 EPHA5	4.02e-03	14	128	2	IPR027936
Domain	EPH_lbd	EPHA10 EPHA5	4.02e-03	14	128	2	SM00615
Domain	Ephrin_lbd	EPHA10 EPHA5	4.02e-03	14	128	2	PF01404
Domain	Tyr_kinase_ephrin_rcpt	EPHA10 EPHA5	4.02e-03	14	128	2	IPR016257
Domain	EPH_LBD	EPHA10 EPHA5	4.02e-03	14	128	2	PS51550
Domain	Growth_fac_rcpt_	LAMA3 SLIT3 LRP2 FBN3 EPHA5	4.43e-03	156	128	5	IPR009030
Domain	TPR_2	TTC28 KLC2 TMTC4	4.87e-03	50	128	3	PF07719
Domain	TPR_2	TTC28 KLC2 TMTC4	4.87e-03	50	128	3	IPR013105
Domain	Guanylate_kinase_CS	CASK MPP4	5.25e-03	16	128	2	IPR020590
Domain	C2_dom	UNC13D PRKCG PRKCH PLCG1 SYT13	5.46e-03	164	128	5	IPR000008
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	LRFN1 APBA1 APBA3 PPFIA3 CASK LRFN2	2.45e-05	87	94	6	M27617
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	MAP1B PNO1 MCM3 SSBP1 NSUN2 WDR26 CASK PNPT1 FASN UGDH PLCG1 PLEC RPL13A SNRPF ALPK2 KDM1A	7.30e-08	809	131	16	32129710
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LRFN1 LINGO3 LRFN2 PXDN AMIGO3	1.79e-07	34	131	5	18848646
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SPHK2 LRFN1 BTAF1 MED13L NPHP4 ITPR2 FASN TKFC KLHL21 KANK3 TMEM268 ZFYVE26 PLCG1 PLEC MED13 AHNAK2 AGTRAP TJP3	1.91e-07	1105	131	18	35748872
Pubmed	The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence.	PKHD1L1 PKHD1 LRP2	5.19e-07	5	131	3	20048263
Pubmed	Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting.	APBA1 APBA3 CASK	5.19e-07	5	131	3	9822620
Pubmed	Arf4 is required for Mammalian development but dispensable for ciliary assembly.	PKHD1L1 PKHD1 LRP2	1.81e-06	7	131	3	24586199
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	ITPR2 PRKCG PRKCH PLCG1	1.93e-06	24	131	4	10843712
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	GNL3L MAP1B BCKDK SPTBN2 MCM3 UFL1 BTAF1 SSBP1 GOSR2 NSUN2 WDR26 ITPR2 LRRC47 THEM6 FASN PXDN SNRPF SLC27A2 AHNAK2	2.02e-06	1440	131	19	30833792
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	HDAC4 KLC2 PNO1 MCM3 MED13L NSUN2 LRRC47 PNPT1 FASN UGDH RPL13A MGA GMPPA SNRPF MED13 KDM1A TJP3	4.78e-06	1247	131	17	27684187
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PRPSAP2 MAP1B BCKDK APBA1 ANKS1B KLC2 PLPPR3 PPFIA3 ECI1 WDR26 RYR2 TENM1 UBR3 PRKCG PLEC RPL13A	6.41e-06	1139	131	16	36417873
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PRPSAP2 KLC2 PNO1 MCM3 UNC13D NSUN2 WDR26 LRRC47 NEDD8 GTF2E2 FASN TKFC UGDH PLCG1 PLEC GMPPA SNRPF AHNAK2	9.29e-06	1455	131	18	22863883
Pubmed	Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.	MED13L MED13	1.41e-05	2	131	2	29325037
Pubmed	Molecular analysis of the X11-mLin-2/CASK complex in brain.	APBA1 CASK	1.41e-05	2	131	2	9952408
Pubmed	Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes.	RYR2 ITPR2	1.41e-05	2	131	2	28158491
Pubmed	Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides.	CYBB RYR2	1.41e-05	2	131	2	24104877
Pubmed	Novel autosomal recessive LAMA3 and PLEC variants underlie junctional epidermolysis bullosa generalized intermediate and epidermolysis bullosa simplex with muscular dystrophy in two consanguineous families.	LAMA3 PLEC	1.41e-05	2	131	2	29797489
Pubmed	Mitochondrial calcium overload is a key determinant in heart failure.	RYR2 ITPR2	1.41e-05	2	131	2	26217001
Pubmed	Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population.	ITPR2 PDZD2	1.41e-05	2	131	2	26918600
Pubmed	EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.	PRKCG PRKCH PLCG1	1.45e-05	13	131	3	12761849
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	COL15A1 HAPLN2 NEDD8 AEBP1 PRKCG PRKCH PLCG1	1.57e-05	210	131	7	16537572
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	UFL1 NSUN2 LRRC47 NEDD8 FASN TKFC MOGS UGDH PLEC RPL13A SNRPF SLC27A2	1.68e-05	711	131	12	33022573
Pubmed	FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.	MED13L NEDD8 MED13	2.30e-05	15	131	3	31285543
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	LAMA3 GRIP1 FREM2	2.82e-05	16	131	3	16880404
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SPNS1 TTC28 WDR26 NEDD8 FASN LRP2 PLEC MGA KDM1A	3.12e-05	418	131	9	34709266
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	PRPSAP2 MCM3 LRRC47 PNPT1 FASN PLCG1 KDM1A	3.40e-05	237	131	7	29564676
Pubmed	Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B.	PRKCG PLCG1	4.21e-05	3	131	2	19531484
Pubmed	NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers.	CYBB HDAC4	4.21e-05	3	131	2	22648949
Pubmed	Association of neuronal calcium channels with modular adaptor proteins.	APBA1 CASK	4.21e-05	3	131	2	10455105
Pubmed	MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils.	CYBB UNC13D	4.21e-05	3	131	2	23115246
Pubmed	The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers.	MUC16 FASN	4.21e-05	3	131	2	32698888
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	PRPSAP2 MAP1B SPTBN2 MCM3 NSUN2 WDR26 FASN PLEC RPL13A MGA	4.78e-05	551	131	10	34728620
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	MAP1B MCM3 WDR26 LRRC47 FASN RPL13A MGA	5.54e-05	256	131	7	32698014
Pubmed	SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.	MAP1B SSBP1 NSUN2 UGDH PLEC RPL13A MGA SNRPF	6.09e-05	353	131	8	27545878
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SPNS1 MAP1B BCKDK SPTBN2 MCM3 UFL1 SIM1 CCDC61 CASK THEM6 PNPT1 MOGS PLEC SNRPF	6.12e-05	1082	131	14	38697112
Pubmed	A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.	PRPSAP2 MAP1B PLEC	6.61e-05	21	131	3	24923560
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	BTAF1 MED13L WDR26 FASN PLEC MGA MED13	8.10e-05	272	131	7	31010829
Pubmed	A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function.	APBA1 APBA3	8.41e-05	4	131	2	30988517
Pubmed	Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.	APBA1 APBA3	8.41e-05	4	131	2	17167098
Pubmed	ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization.	ANKS1B CASK	8.41e-05	4	131	2	26085624
Pubmed	Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization.	PRKCG PLCG1	8.41e-05	4	131	2	15367584
Pubmed	Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure.	MPDZ MPP4	8.41e-05	4	131	2	15316081
Pubmed	The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules.	LRFN1 LRFN2	8.41e-05	4	131	2	21736948
Pubmed	Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.	APBA1 APBA3	8.41e-05	4	131	2	19118172
Pubmed	Novel mediators of amyloid precursor protein signaling.	APBA1 APBA3	8.41e-05	4	131	2	20016085
Pubmed	Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid β generation.	APBA1 APBA3	8.41e-05	4	131	2	24742670
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR2 ITPR2	8.41e-05	4	131	2	19120137
Pubmed	Influence of breastfeeding on blood-cell transcript-based biomarkers of health in children.	FASN SLC27A2	8.41e-05	4	131	2	24277691
Pubmed	Mints as adaptors. Direct binding to neurexins and recruitment of munc18.	APBA1 CASK	8.41e-05	4	131	2	11036064
Pubmed	FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.	MED13L MED13	8.41e-05	4	131	2	29809150
Pubmed	Signaling via amyloid precursor-like proteins APLP1 and APLP2.	APBA1 APBA3	8.41e-05	4	131	2	21178287
Pubmed	The molecular basis of the Caskin1 and Mint1 interaction with CASK.	APBA1 CASK	8.41e-05	4	131	2	21763699
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	HDAC4 KLC2 MCM3 SSBP1 FASN SLC27A2	8.72e-05	190	131	6	15161933
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	TTC28 BCKDK SPTBN2 KLC2 MCM3 SSBP1 CEP164 GRIP1 LRP2 PLEC MGA PDZRN3	9.68e-05	853	131	12	28718761
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	MCM3 UFL1 NSUN2 MOGS	1.03e-04	64	131	4	26511642
Pubmed	SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.	LRFN1 CASK LRFN2	1.13e-04	25	131	3	27480238
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	HDAC4 TTC28 SPTBN2 MED13 PDZD2	1.38e-04	130	131	5	12421765
Pubmed	Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein.	APBA1 APBA3	1.40e-04	5	131	2	12842896
Pubmed	Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains.	APBA1 CASK	1.40e-04	5	131	2	12093160
Pubmed	Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach.	APBA1 CASK	1.40e-04	5	131	2	12006486
Pubmed	Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.	FREM2 SLIT3	1.40e-04	5	131	2	23536828
Pubmed	The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing.	PPFIA3 GRIP1	1.40e-04	5	131	2	19013515
Pubmed	Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice.	APBA1 CASK	1.40e-04	5	131	2	11104771
Pubmed	Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins.	CYBB SPHK2	1.40e-04	5	131	2	23933064
Pubmed	Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.	PRKCG PRKCH PLCG1	1.43e-04	27	131	3	20336759
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	SSBP1 PKHD1 LRP2 RPL13A NLRP5 TDRD12	1.43e-04	208	131	6	33230847
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SPNS1 BCKDK SPTBN2 MPDZ UFL1 SSBP1 GOSR2 CCDC61 ITPR2 CASK LRRC47 THEM6 PNPT1 GTF2E2 MOGS RPL13A	1.55e-04	1487	131	16	33957083
Pubmed	Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model.	MUC16 SSBP1 FASN RPL13A SNRPF	1.65e-04	135	131	5	31405213
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	COL15A1 TTC28 BCKDK UFL1 SSBP1 GOSR2 ITPR2 CASK SPTBN5 THEM6 PNPT1 LRP2 PRKCH RPL13A MIEF2 AHNAK2	1.66e-04	1496	131	16	32877691
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	LAMA3 GRIP1 FREM2	1.78e-04	29	131	3	22613833
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TTC28 MUC16 MAGEC3 MCM3 PKHD1L1 RYR2 CASK GTF2E2 UGDH PRKCH MGA	1.81e-04	777	131	11	35844135
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GNL3L MAP1B PNO1 MCM3 SSBP1 NSUN2 LRRC47 FASN UGDH PLCG1 PLEC RPL13A MGA KDM1A AHNAK2	1.83e-04	1353	131	15	29467282
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	MAP1B SSBP1 NSUN2 FASN PLEC SNRPF AHNAK2	1.89e-04	312	131	7	37120454
Pubmed	Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.	APBA1 PPFIA3 CASK	1.97e-04	30	131	3	16186258
Pubmed	SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.	CYBB HLA-DQB2	2.09e-04	6	131	2	20818396
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR2 ITPR2	2.09e-04	6	131	2	23463619
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR2 PLCG1	2.09e-04	6	131	2	21762810
Pubmed	Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms.	APBA1 APBA3	2.09e-04	6	131	2	12196555
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR2 ITPR2	2.09e-04	6	131	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR2 ITPR2	2.09e-04	6	131	2	25966694
Pubmed	Junctional Epidermolysis Bullosa	LAMA3 PLEC	2.09e-04	6	131	2	20301304
Pubmed	FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response.	SSBP1 FBXL5	2.09e-04	6	131	2	25249620
Pubmed	Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.	GRIP1 FREM2	2.09e-04	6	131	2	24700879
Pubmed	Rab11-FIP2 suppressed tumor growth via regulation of PGK1 ubiquitination in non-small cell lung cancer.	MCM3 WDR26	2.09e-04	6	131	2	30471866
Pubmed	Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.	GRIP1 FREM2	2.09e-04	6	131	2	17462874
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR2 ITPR2	2.09e-04	6	131	2	16844763
Pubmed	Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages.	PRKCG PLCG1	2.09e-04	6	131	2	15006698
Pubmed	Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling.	UNC13D GZMM	2.09e-04	6	131	2	25526309
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TTC28 MAP1B SPTBN2 MPDZ MCM3 GTF2E2 FASN MGA KDM1A	2.45e-04	549	131	9	38280479
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	GNL3L SPTBN2 LAMA3 PNO1 MCM3 SSBP1 NSUN2 ITPR2 LRRC47 FASN MOGS PLEC RPL13A SNRPF	2.90e-04	1257	131	14	36526897
Pubmed	A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.	APBA1 CASK	2.92e-04	7	131	2	9753324
Pubmed	Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping.	MPDZ PDZD2	2.92e-04	7	131	2	17619104
Pubmed	Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins.	LRFN1 LRFN2	2.92e-04	7	131	2	16828986
Pubmed	The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.	MED13L MED13	2.92e-04	7	131	2	12093747
Pubmed	Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.	HLA-DQB2 PLCG1	2.92e-04	7	131	2	22561606
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR2 ITPR2	2.92e-04	7	131	2	11860456
Pubmed	A novel family of adhesion-like molecules that interacts with the NMDA receptor.	LRFN1 LRFN2	2.92e-04	7	131	2	16495444
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	LRFN1 HDAC4 SPTBN2 ANKS1B MPDZ MCM3 PPFIA3 WDR26 CASK PRKCG MGA KDM1A	2.95e-04	963	131	12	28671696
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	PRPSAP2 PNO1 MCM3 UFL1 SSBP1 NSUN2 LRRC47 PNPT1 GTF2E2 FASN MOGS PLEC RPL13A SNRPF AHNAK2	2.95e-04	1415	131	15	28515276
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	APBA1 PDZD2 TJP3	3.13e-04	35	131	3	33864728
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MAP1B SPTBN2 ANKS1B HAPLN2 KLC2 PPFIA3 ECI1 ITPR2 CASK LRRC47 GTF2E2 FASN PRKCG PLEC RPL13A	3.33e-04	1431	131	15	37142655
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	REX1BD MRI1 MUC16 APBA3 PLPPR3 LINGO3 KANK3 GZMM CREB3L3 FBN3 TJP3	2.08e-05	797	132	11	chr19p13
Cytoband	19p13.3	APBA3 PLPPR3 LINGO3 GZMM CREB3L3 TJP3	6.76e-05	237	132	6	19p13.3
Cytoband	20q12-q13.1	RBPJL PLCG1	3.64e-04	10	132	2	20q12-q13.1
GeneFamily	PDZ domain containing	CNKSR1 MAGIX APBA1 MPDZ APBA3 CASK GRIP1 MPP4 PDZRN3 AHNAK2 PDZD2 TJP3	4.66e-12	152	83	12	1220
GeneFamily	Sterile alpha motif domain containing	CNKSR1 ANKS1B PPFIA3 EPHA10 EPHA5	5.25e-05	88	83	5	760
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	CASK MPP4 TJP3	2.25e-04	26	83	3	904
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN2 SPTBN5	4.31e-04	7	83	2	1113
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRFN1 LINGO3 LRFN2 PXDN ALPK2	8.73e-04	161	83	5	593
GeneFamily	C2 domain containing protein kinases	PRKCG PRKCH	9.15e-04	10	83	2	835
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA10 EPHA5	1.83e-03	14	83	2	1095
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A PKHD1L1 RYR2 FREM2 PKHD1 TENM1 LRP2 HYDIN EPHA10 EPHA5	2.07e-10	184	132	10	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A PKHD1L1 RYR2 FREM2 PKHD1 TENM1 LRP2 HYDIN EPHA10 EPHA5	2.07e-10	184	132	10	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A PKHD1L1 RYR2 FREM2 PKHD1 TENM1 LRP2 HYDIN EPHA10 EPHA5	2.07e-10	184	132	10	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANKS1B SIM1 PKHD1L1 FREM2 PKHD1 TENM1 LGR6 HYDIN EPHA5	1.41e-09	162	132	9	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A PKHD1L1 RYR2 GRIP1 PKHD1 LRP2 HYDIN EPHA5	2.72e-08	160	132	8	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A PKHD1L1 RYR2 GRIP1 PKHD1 LRP2 HYDIN EPHA5	2.72e-08	160	132	8	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CNKSR1 MAB21L4 LAMA3 PKHD1 PRKCG FBN3 AHNAK2	3.47e-08	108	132	7	d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A PKHD1L1 RYR2 AEBP1 PKHD1 LRP2 RPL13A HYDIN	4.16e-08	169	132	8	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANKS1B MUC16 GRIP1 FREM2 AEBP1 SLC17A9 LRP2 AHNAK2	5.70e-08	176	132	8	8e7f38de8bf68077e2138f4d06c1f55b0fd096cc
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANKS1B MUC16 GRIP1 FREM2 AEBP1 SLC17A9 LRP2 AHNAK2	5.70e-08	176	132	8	ed575330a08a6748ea4b28433292c8cfd157d444
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	COL15A1 MAP1B MAGEC3 RYR2 AEBP1 SLIT3 LGR6 PDZRN3	6.78e-08	180	132	8	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAB21L4 LAMA3 UNC13D GRIP1 PKHD1 SLC39A5 TJP3	4.50e-07	157	132	7	9665a1375cfd8e9b8781c852686591226c0e0d9a
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CYBB LRFN1 MAGIX PPFIA3 SLIT3 SLC27A2 EPHA5	5.12e-07	160	132	7	bb1bb3673059768c0ea0160d29fff127f3a4ecb4
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYBB LRFN1 MAGIX PPFIA3 SLIT3 SLC27A2 EPHA5	5.12e-07	160	132	7	76f49b8b4450fa8acd36326bfa36a5d1f4bd95fb
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 FADS6 PKHD1L1 GRIP1 FREM2 AEBP1 AHNAK2	6.83e-07	167	132	7	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 FADS6 PKHD1L1 GRIP1 FREM2 AEBP1 AHNAK2	6.83e-07	167	132	7	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRIP1 LRFN2 SLIT3 PKHD1 LRP2 HYDIN ALPK2	7.11e-07	168	132	7	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	TTC28 APBA1 CCDC85A AEBP1 SLIT3 LRP2 ALPK2	8.33e-07	172	132	7	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL15A1 MAP1B ANKS1B MAGEC3 RYR2 LGR6 PDZRN3	8.66e-07	173	132	7	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1L1 RYR2 AEBP1 LRP2 RPL13A RTN4RL2 HYDIN	8.66e-07	173	132	7	66f37c1437705734b20601656fa4aa1d92ca30be
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1L1 RYR2 AEBP1 LRP2 RPL13A RTN4RL2 HYDIN	8.66e-07	173	132	7	649b08a409095592cccf31883be69c754411280d
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR2 PKHD1 LRP2 RPL13A HYDIN SYT13 EPHA5	9.35e-07	175	132	7	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAB21L4 LAMA3 UNC13D APOLD1 PKHD1 PRKCG	9.49e-07	110	132	6	c80d1c3df75648e2c8f6832279c2acca63d76681
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 FADS6 PKHD1L1 FREM2 AEBP1 LRP2 AHNAK2	1.05e-06	178	132	7	a107dd98a07086ed0429116095ecda60c9dbef1e
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	APBA1 LAMA3 CCDC85A PXDN AEBP1 SLIT3 ALPK2	1.09e-06	179	132	7	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CNKSR1 NPHP4 PKHD1L1 RYR2 SPTBN5 MOGS AMIGO3	1.13e-06	180	132	7	8e96f8646c002768b272359af485dc0ab57e0ccd
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRIP1 PKHD1 TENM1 LRP2 HYDIN ALPK2 SLC27A2	1.26e-06	183	132	7	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	ANKS1B GRIP1 PKHD1 LRP2 HYDIN ALPK2 SLC27A2	1.31e-06	184	132	7	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYBB LAMA3 MUC16 MED13L RYR2 PKHD1 PLEC	1.41e-06	186	132	7	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	AT1_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	MAB21L4 MROH2A LAMA3 UNC13D CCDC85A PXDN FBN3	1.46e-06	187	132	7	f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1B SPTBN2 PPFIA3 RYR2 PRKCG RTN4RL2 EPHA10	1.46e-06	187	132	7	e04a84989d624378141042768383b9c846901f2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1B SPTBN2 PPFIA3 RYR2 PRKCG RTN4RL2 EPHA10	1.46e-06	187	132	7	24cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1B SPTBN2 PPFIA3 RYR2 PRKCG RTN4RL2 EPHA10	1.46e-06	187	132	7	2f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CNKSR1 SPTBN2 MUC16 PTPN21 PXDN AHNAK2 TJP3	1.74e-06	192	132	7	8899d81306770adda893b5e146df1253971754c5
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CNKSR1 SPTBN2 MUC16 PTPN21 PXDN AHNAK2 TJP3	1.74e-06	192	132	7	5fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	MAP1B PXDN AEBP1 SCARA5 SLIT3 UGDH AHNAK2	2.13e-06	198	132	7	4f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL15A1 MAP1B RYR2 PXDN AEBP1 SLIT3 PDZRN3	2.20e-06	199	132	7	b1753474152b82a0b811b9878c890a359e14919a
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	CCDC85A RYR2 FASN TENM1 LGR6 PLEC SYT13	2.28e-06	200	132	7	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	MAP1B PLPPR3 GRIP1 TENM1 PDZRN3 SYT13 EPHA5	2.28e-06	200	132	7	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIM1 FREM2 PKHD1 TENM1 HYDIN EPHA5	4.74e-06	145	132	6	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	APBA1 CCDC85A LRFN2 AEBP1 SLIT3 ALPK2	7.21e-06	156	132	6	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	APBA1 CCDC85A LRFN2 AEBP1 SLIT3 ALPK2	7.21e-06	156	132	6	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	COVID-19-lung-Mesothelial\|lung / Disease (COVID-19 only), tissue and cell type	MAP1B ANKS1B MUC16 PKHD1L1 GRIP1 EPHA5	7.21e-06	156	132	6	e1f563869b3bf997eaa2e756e31b53db1a478903
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MAB21L4 CCDC61 CEP164 GZMM TENM1 ALPK2	8.33e-06	160	132	6	79e833c904c762434993b5ec9d5e3540e695fad3
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PKHD1L1 GRIP1 AEBP1 LRP2 AHNAK2	1.06e-05	167	132	6	c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PKHD1L1 GRIP1 AEBP1 LRP2 AHNAK2	1.06e-05	167	132	6	351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MROH2A ANKS1B TENM1 LRP2 SLC27A2 PDZD2	1.22e-05	171	132	6	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RYR2 FREM2 AEBP1 SLIT3 LGR6 PDZRN3	1.22e-05	171	132	6	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	MAP1B RYR2 PXDN SLIT3 LGR6 PDZRN3	1.26e-05	172	132	6	c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MUC16 FADS6 PKHD1L1 GRIP1 FREM2 AEBP1	1.26e-05	172	132	6	9a256db817c1af1802203cc88a55d608fb328c63
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PKHD1L1 GRIP1 FREM2 AEBP1 AHNAK2	1.30e-05	173	132	6	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PKHD1L1 GRIP1 FREM2 AEBP1 AHNAK2	1.34e-05	174	132	6	a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CNKSR1 MUC16 PKHD1L1 AMIGO3 SLC17A9 FBN3	1.39e-05	175	132	6	3b5346fba617292de71963b6175e85a4f182fe30
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CNKSR1 MUC16 PKHD1L1 AMIGO3 SLC17A9 FBN3	1.43e-05	176	132	6	dc4e939a07bad21ab36181f9588df3fa662f9a92
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B LRP2 SLC39A5 ALPK2 SLC27A2 PDZD2	1.43e-05	176	132	6	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	AT1_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	MAB21L4 LAMA3 PTPN21 CCDC85A PXDN AHNAK2	1.48e-05	177	132	6	3128b8d04687acee1ac4190b2569d6328b98eaf3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B PKHD1 LRP2 ALPK2 SLC27A2 PDZD2	1.48e-05	177	132	6	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MUC16 PKHD1L1 GRIP1 FREM2 AEBP1 LRP2	1.53e-05	178	132	6	1e05bc26591fea16e29bcfc5f538dda1dc427f05
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PKHD1L1 FREM2 AEBP1 LRP2 AHNAK2	1.53e-05	178	132	6	bcbdd45a2307f8aea14122fa0144b96b1f6eec48
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	APOLD1 GZMM TENM1 PLCG1 SYT13 SLC27A2	1.53e-05	178	132	6	f94e306b9550f3d1b5de0bb806790c17823d439e
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PKHD1L1 FREM2 AEBP1 LRP2 AHNAK2	1.53e-05	178	132	6	c413861148129be1ee94f2ceb5999840217eebe5
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRIP1 SLIT3 PKHD1 LRP2 HYDIN ALPK2	1.53e-05	178	132	6	544379f5a6145429762258d426b876bb36c112f5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B LRP2 SLC39A5 ALPK2 SLC27A2 PDZD2	1.58e-05	179	132	6	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	Control-Stromal-SMC\|Control / Disease state, Lineage and Cell class	COL15A1 MAP1B HAPLN2 AEBP1 SLIT3 PDZRN3	1.58e-05	179	132	6	1378051bc62009eec2dbecf3d5d89baedbeb84eb
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRIP1 PKHD1 TENM1 LRP2 ALPK2 SLC27A2	1.63e-05	180	132	6	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ANKS1B MUC16 PKHD1L1 GRIP1 FREM2 AEBP1	1.63e-05	180	132	6	2ccc77d769d3ffd77ab3af45e4f192785b6db79c
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PKHD1L1 GRIP1 AEBP1 LRP2 AHNAK2	1.68e-05	181	132	6	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAB21L4 LAMA3 UNC13D GRIP1 PKHD1 TJP3	1.68e-05	181	132	6	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PKHD1L1 GRIP1 AEBP1 LRP2 AHNAK2	1.68e-05	181	132	6	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FREM2 PKHD1 TENM1 LRP2 SLC39A5 SLC27A2	1.68e-05	181	132	6	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-7\|TCGA-Prostate / Sample_Type by Project: Shred V9	LRFN1 SPTBN2 KLC2 NSUN2 THEM6 EPHA10	1.73e-05	182	132	6	af16334fec2c757b03c84cf252d00e92fa81e4cd
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 PKHD1L1 FREM2 AEBP1 LRP2 AHNAK2	1.73e-05	182	132	6	9966f42c338cbd471efa8ffc765a6ce93693aa75
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B LRP2 SLC39A5 ALPK2 SLC27A2 PDZD2	1.79e-05	183	132	6	85446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell	COVID-19-kidney-PCT-S1/S2\|kidney / Disease (COVID-19 only), tissue and cell type	ANKS1B LRP2 PDZRN3 ALPK2 SLC27A2 PDZD2	1.84e-05	184	132	6	dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MUC16 FADS6 PKHD1L1 GRIP1 FREM2 AEBP1	1.84e-05	184	132	6	607b55022de21ddb6a2d75e085df76df7abf6624
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MROH2A LAMA3 FREM2 PKHD1 LRP2 SLC27A2	1.84e-05	184	132	6	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	APBA1 CCDC85A LRFN2 AEBP1 SLIT3 ALPK2	1.90e-05	185	132	6	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	APBA1 CCDC85A LRFN2 AEBP1 SLIT3 ALPK2	1.90e-05	185	132	6	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B LRP2 SLC39A5 ALPK2 SLC27A2 PDZD2	1.96e-05	186	132	6	8287146f0ba415ea04475588117d4668ae00f75c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B LRP2 SLC39A5 ALPK2 SLC27A2 PDZD2	1.96e-05	186	132	6	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LAMA3 GRIP1 FREM2 PKHD1 LRP2 SLC27A2	1.96e-05	186	132	6	bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TTC28 GRIP1 PKHD1 LRP2 HYDIN ALPK2	1.96e-05	186	132	6	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B LRP2 SLC39A5 ALPK2 SLC27A2 PDZD2	2.02e-05	187	132	6	1b82920588f9e26ef1db244d452736d75fcfd342
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B LRP2 SLC39A5 ALPK2 SLC27A2 PDZD2	2.02e-05	187	132	6	71eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PKHD1 TENM1 LRP2 ALPK2 SLC27A2 PDZD2	2.02e-05	187	132	6	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PKHD1L1 AEBP1 SCARA5 SLIT3 LRP2	2.02e-05	187	132	6	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PKHD1L1 AEBP1 SCARA5 SLIT3 LRP2	2.02e-05	187	132	6	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PKHD1L1 AEBP1 SCARA5 SLIT3 LRP2	2.02e-05	187	132	6	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PKHD1 TENM1 LRP2 ALPK2 SLC27A2 PDZD2	2.02e-05	187	132	6	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKS1B LRP2 SLC39A5 ALPK2 SLC27A2 PDZD2	2.02e-05	187	132	6	c1e4c0345f9bfa0538730bad5ff3fa5240168b25
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	UNC13D RYR2 GRIP1 PPP1R42 ALPK2 EPHA5	2.08e-05	188	132	6	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	APBA1 LAMA3 CCDC85A LRFN2 SLIT3 ALPK2	2.08e-05	188	132	6	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	APBA1 LAMA3 CCDC85A LRFN2 SLIT3 ALPK2	2.08e-05	188	132	6	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	MAP1B MUC16 PKHD1L1 AEBP1 SLIT3 UGDH	2.14e-05	189	132	6	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC4 SPTBN2 SIM1 GRIP1 PKHD1 TRPV5	2.14e-05	189	132	6	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D231\|Adult / Lineage, Cell type, age group and donor	ANKS1B LAMA3 UNC13D PTPN21 CCDC85A PDZD2	2.14e-05	189	132	6	5a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAP1B RYR2 AEBP1 SLIT3 LGR6 PDZRN3	2.14e-05	189	132	6	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	human_hepatoblastoma-Endothelial_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	MAP1B CCDC85A PXDN KANK3 PRKCH PDZD2	2.21e-05	190	132	6	8d6ef93d69e96cd6921816d152bea3b0710cf147
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	COL15A1 RYR2 AEBP1 SLIT3 TENM1 PPP1R42	2.27e-05	191	132	6	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TTC28 GRIP1 PKHD1 LRP2 HYDIN ALPK2	2.27e-05	191	132	6	1cb02007adb344f17ef73d58890f91298c7cf5a1
Disease	Intellectual Disability	CNKSR1 HDAC4 MAP1B BCKDK MED13L NSUN2 WDR26 PNPT1 FASN LRP2 PRKCG MED13	5.64e-07	447	127	12	C3714756
Disease	Spinocerebellar ataxia 14	SPTBN2 PRKCG	1.84e-05	2	127	2	C1854369
Disease	Developmental delay (disorder)	SPTBN2 PNPT1 TKFC KDM1A	1.94e-05	37	127	4	C0424605
Disease	Cryptophthalmos syndrome	GRIP1 FREM2	5.50e-05	3	127	2	C0265233
Disease	FRASER SYNDROME 1	GRIP1 FREM2	5.50e-05	3	127	2	C4551480
Disease	Fraser syndrome (implicated_via_orthology)	GRIP1 FREM2	1.10e-04	4	127	2	DOID:0090001 (implicated_via_orthology)
Disease	pappalysin‐1 measurement	PLPPR3 PXDN RTN4RL2	2.62e-04	29	127	3	EFO_0010618
Disease	Profound Mental Retardation	CNKSR1 HDAC4 MED13L FASN PRKCG	3.46e-04	139	127	5	C0020796
Disease	Mental Retardation, Psychosocial	CNKSR1 HDAC4 MED13L FASN PRKCG	3.46e-04	139	127	5	C0025363
Disease	Mental deficiency	CNKSR1 HDAC4 MED13L FASN PRKCG	3.46e-04	139	127	5	C0917816
Disease	obesity (implicated_via_orthology)	SPHK2 GNL3L SIM1 MED13L ITPR2 MED13	3.47e-04	215	127	6	DOID:9970 (implicated_via_orthology)
Disease	ascending aortic diameter	UNC13D MED13L CEP164 RYR2 HYDIN	3.58e-04	140	127	5	EFO_0021787
Disease	Inherited neuropathies	SPTBN2 PRKCG ZFYVE26	6.85e-04	40	127	3	C0598589
Disease	peptidoglycan recognition protein 1 measurement	HLA-DQB2 CCDC61	8.09e-04	10	127	2	EFO_0020624
Disease	autosomal dominant nonsyndromic deafness (is_implicated_in)	MAP1B EPHA10	9.86e-04	11	127	2	DOID:0050564 (is_implicated_in)
Disease	Renal dysplasia and retinal aplasia (disorder)	NPHP4 CEP164	1.18e-03	12	127	2	C0403553
Disease	pulmonary function measurement, FEV/FEC ratio	HDAC4 HLA-DQB2 SNRPF	1.56e-03	53	127	3	EFO_0003892, EFO_0004713
Disease	velopharyngeal dysfunction	TTC28 MPDZ ITPR2 LILRA4	1.94e-03	122	127	4	EFO_0009336
Disease	T-Cell Lymphoma	MGA KDM1A	2.12e-03	16	127	2	C0079772
Disease	Tinnitus	APBA1 PNPT1 SCARA5 PKHD1	2.45e-03	130	127	4	HP_0000360
Disease	Global developmental delay	SPTBN2 PNPT1 TKFC KDM1A	2.66e-03	133	127	4	C0557874
Disease	pulse pressure measurement	COL15A1 TTC28 MAP1B PNO1 UNC13D MED13L GOSR2 CEP164 PNPT1 FASN SLIT3 UBR3 HYDIN KDM1A	2.72e-03	1392	127	14	EFO_0005763
Disease	age at onset, smoking initiation	ITPR2 GRIP1	3.00e-03	19	127	2	EFO_0004847, EFO_0005670
Disease	amyotrophic lateral sclerosis	HLA-DQB2 LAMA3 ITPR2 PNPT1	3.62e-03	145	127	4	MONDO_0004976
Disease	Autoimmune Hepatitis	HLA-DQB2 LILRA4	3.66e-03	21	127	2	EFO_0005676
Disease	juvenile idiopathic arthritis	HLA-DQB2 NPHP4 FASN	4.04e-03	74	127	3	EFO_0002609

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHSVAGELRLGLDGT	SYT13	251	Q7L8C5
LELELRQERGLGHRV	CCDC61	226	Q9Y6R9
DRQDGILRHVELGEG	CREB3L3	31	Q68CJ9
GGRLRGQIATEELHF	ALPK2	1911	Q86TB3
TAGIHGNEVLGRELL	AEBP1	621	Q8IUX7
TLEDLRRLGVTLVGH	EPHA5	1001	P54756
GLTHQGGRLSRVLRE	GZMM	151	P51124
HLEKRRGEGLGVALV	APBA3	396	O96018
ERGGIRVGHRIIEIN	APBA3	516	O96018
LRALGRHDLDGLGAL	AMIGO3	121	Q86WK7
GLNLSHLGRAERILE	FBN3	2711	Q75N90
IRISDRGGGIAHKDL	BCKDK	311	O14874
EELGTHGEGALRVLL	C17orf113	531	A0A1B0GUU1
GLGSLDRLLLHGNRL	RTN4RL2	201	Q86UN3
LRLVLRGGRELGTFH	RBPJL	171	Q9UBG7
GGLQIHDRIIEVNGR	PDZRN3	296	Q9UPQ7
GIVAVILRIHSAGGR	OR6K2	221	Q8NGY2
DEGGRTFLRVLIHLI	ITPR2	1051	Q14571
HGLQLRIATRGAEQL	NSUN2	296	Q08J23
FQGLLLDRRGRLHGQ	APOLD1	51	Q96LR9
DLLEIGILNSGHRQR	ANKS1B	851	Q7Z6G8
RLLGELGSLQGHRLD	MAB21L4	256	Q08AI8
TLDQHLGIRSLGRTG	MUC16	1516	Q8WXI7
NGIERLRAGLGILHD	OSGEPL1	366	Q9H4B0
LRAGLGILHDIEGIR	OSGEPL1	371	Q9H4B0
TLVLLGAHGVGRRHI	CASK	741	O14936
RLGLGRFTLIEEGDH	LILRA4	146	P59901
GRIVLALEGGHDLTA	HDAC4	966	P56524
HLRRAIGNIELGIRS	MAP1B	51	P46821
VVIGRLGRLGHGELK	MED13L	1896	Q71F56
LGHLREVRLFLRGGT	MAGEC3	56	Q8TD91
GRLEVGDLVLHINGE	MAGIX	166	Q9H6Y5
LTTLRDGLHGIQRGD	LAMA3	2266	Q16787
VLHLVLALRGGGGLR	NEDD8	66	Q15843
GHRLDASLVIAGVRL	HAPLN2	106	Q9GZV7
ALDSVRERLHGGKGL	MGA	1436	Q8IWI9
VAIRTLGRLQELGFH	LGR6	251	Q9HBX8
RQGRREEAGTLLQHL	LRRC75A	66	Q8NAA5
VGDAGRLLLRVLHVS	LRRC47	301	Q8N1G4
DGLATAQLRLRELGH	PPFIA3	51	O75145
DQLRGLGNLRHLILG	LRFN1	131	Q9P244
RVHGQLRGLDTTDIG	KIAA1109	1826	Q2LD37
LEAVRLEVVAGLRHG	FREM2	476	Q5SZK8
DTGNLEGTVHRILLG	CARF	656	Q8N187
LIFLGLGLIIRHRGQ	HLA-DQB2	241	P05538
GRLSLGDELLVINGH	PDZD2	376	O15018
GLRPGQHLILRGIVD	CYB5RL	106	Q6IPT4
DILVARIIHGGLAER	MPP4	176	Q96JB8
GESLGHLRSLGALRL	LINGO3	191	P0C6S8
ILDGHNILDGLRTQR	GOSR2	141	O14653
GVDHTERRGRLQLEI	PRKCG	151	P05129
GISGEQRIHLLLERG	NLRP5	431	P59047
GRDLLIGDIHGRSFR	LRP2	401	P98164
LKGDHLSRAIGRIAG	PNO1	171	Q9NRX1
LDGFLRRHEGQLVAG	EPHA10	731	Q5JZY3
EILERRLRVGVHNGL	NPHP4	281	O75161
QGLETLRGEHRALLA	KLC2	26	Q9H0B6
LGARVLTRLAEHLGE	MOGS	606	Q13724
AGLSHGLEGLRLKER	PTPN21	641	Q16825
LGIISRQARLHLGEQ	SLC51A	236	Q86UW1
LLGGVERDLENGSHI	MCM3	321	P25205
GVRLRESIVLHGATL	GMPPA	316	Q96IJ6
TIGHRAAERALQLGL	ECI1	196	P42126
IARHLGIDISAEGRL	HYDIN	2016	Q4G0P3
VHGALLSGLREAGRI	KDM1A	811	O60341
ILRHVGELGAEQLER	KLHL21	161	Q9UJP4
VRHGAGTGLREILKA	BTAF1	301	O14981
IAERGGVRVGHRIIE	APBA1	776	Q02410
EVNRRLQLHLGEIRG	CCDC85A	76	Q96PX6
GRLRRITENGLEIEH	C3orf33	81	Q6P1S2
FIGLAIHGAERIVRG	CYBB	216	P04839
SLEHQRGVSELLRGR	KANK3	361	Q6NY19
ERLRLGIAVIHGEAQ	PRPSAP2	201	O60256
ITDHGLRVLTLGGGL	FBXL5	611	Q9UKA1
GLAERTGAIHIGDRI	GRIP1	706	Q9Y3R0
LREGGFLLLHTLLRG	FASN	1336	P49327
GLRLSGVEDGHQRII	COL15A1	121	P39059
RHAGLLDGLARRVGI	SCARA5	201	Q6ZMJ2
LGVLVRHRISLFGND	RYR2	3011	Q92736
GRLRVGALSQLRTEH	MENT	231	Q9BUN1
HRGGEALLRELEVLV	FADS6	26	Q8N9I5
VEGHRQRLAELVLRG	MROH2A	1341	A6NES4
GLSRKHIIEGLRGSL	KCNAB3	171	O43448
HIIEGLRGSLERLQL	KCNAB3	176	O43448
GQLGRGHLTQVVLRL	MIEF2	371	Q96C03
LLRLLDQHDQRGLGG	GTF2E2	151	P29084
EDSHRGAIGLRIALA	TMEM179B	91	Q7Z7N9
GHSLRVLLGDAQRRL	SPATA2L	391	Q8IUW3
GVLGALRELRAHTVL	THEM6	86	Q8WUY1
HKVRLALGNGLRGDV	SLC27A2	331	O14975
EGRTGLVTRDQLLHL	TDRD12	971	Q587J7
RRQLGTIGLTGIHLH	PKDREJ	1141	Q9NTG1
LGEVRTHIRVGVVGL	GNL3L	246	Q9NVN8
GLEGLGELRELHVEN	PPP1R42	111	Q7Z4L9
VGRELGSHLLQTLDG	SIM1	76	P81133
GHLGDRIGGEKVILL	SLC17A9	81	Q9BYT1
SRDGRLLQTLHLGTG	TENM1	1951	Q9UKZ4
RSIGDLGARHLLERV	MRI1	141	Q9BV20
GRHIRLAAEVGLLTR	PKHD1	2941	P08F94
VIGRLGRIGHGELKD	MED13	1861	Q9UHV7
EIGKVTGLNRRELGH	PNPT1	436	Q8TCS8
RLELLQGHLAIRGLQ	SPTBN5	1501	Q9NRC6
RLLEGLRGTALQLVH	PNMA6A	196	P0CW24
LLHSLGLGRVQGLRL	SLC39A5	61	Q6ZMH5
EGGLRAARLHGKTLE	AHNAK2	411	Q8IVF2
QRAELLGHLTGELER	CEP164	876	Q9UPV0
VRSLGHQELILGGVE	CNKSR1	51	Q969H4
RERGGELLVHTGFLG	AGTRAP	111	Q6RW13
GLRSLRVLTLHGNDI	SLIT3	821	O75094
NGALLRHRVLLGVTD	TMEM268	171	Q5VZI3
EDGHKRRILTLGLGF	TMTC4	376	Q5T4D3
GRRVLDGLHNELQTI	UGDH	441	O60701
IIHGGAISRDGRIAI	MPDZ	1036	O75970
GDGLLHEVLNGLLDR	SPHK2	246	Q9NRA0
ERIHGLLEAGRQLVS	SPTBN2	1226	O15020
VLVLDGRGHLLGRLA	RPL13A	6	P40429
LRRHAGGLGLAEREA	PLPPR3	686	Q6T4P5
GHVRSLQELEQTRLG	REX1BD	136	Q96EN9
GVGLGVEISRRLRHS	SPNS1	336	Q9H2V7
LERSLNRVHLLGRVG	SSBP1	26	Q04837
IRDLASHRGLLRQGI	PXDN	926	Q92626
GAGRDGRHIAERLLT	PLCG1	556	P19174
TRIKEGGLFRQHVLG	PKHD1L1	1016	Q86WI1
GGLFRQHVLGDLLRT	PKHD1L1	1021	Q86WI1
REHGIRLLEAQIATG	PLEC	2936	Q15149
GLVLRQHGIRLLEAQ	PLEC	3591	Q15149
IDGALSGHLGEVLIR	SNRPF	51	P62306
LGEREISDLLRGIHR	ZSWIM2	101	Q8NEG5
ARHRGLQEGDLILQI	TJP3	226	O95049
GRREDEAKIRHGLGL	TTC28	1111	Q96AY4
RTNLELELIHRGGNL	UBR3	1456	Q6ZT12
DVIRLIGQHLNGLGL	WDR26	126	Q9H7D7
LGLGIHGEAGVRRIK	TKFC	216	Q3LXA3
RGRRIDHVLLNADGI	ZFYVE26	1006	Q68DK2
GLGHEIRTGVRTLAE	UNC13D	751	Q70J99
ALTQRLGRIISGHID	UFL1	156	O94874
LGRIISGHIDLDNRG	UFL1	161	O94874
DVRQRGALGETALHI	TRPV5	71	Q9NQA5
RLGSLTQGGEHAILR	PRKCH	596	P24723
ELRLGGNFIIHISRQ	LRFN2	56	Q9ULH4