Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR8H3 OR11L1 OR8U1 OR4Q2 OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	4.67e-17	431	73	20	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8H3 OR11L1 TAS2R13 OR8U1 OR4Q2 MLNR OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 GRM7 OR10Z1 OR8U9 OR2A2 OR1D2	3.79e-14	884	73	23	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR8H3 OR11L1 TAS2R13 OR8U1 OR4Q2 MLNR OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 KIR3DL1 GRM7 OR10Z1 OR8U9 OR2A2 OR1D2	3.38e-11	1353	73	24	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR8H3 OR11L1 OR8U1 OR5C1 OR5B21 OR8U3 OR10Z1 OR8U9	2.04e-08	127	73	8	GO:0005549
GeneOntologyMolecularFunction	6-phosphofructokinase activity	PFKL PFKM PFKP	4.69e-08	3	73	3	GO:0003872
GeneOntologyMolecularFunction	fructose-6-phosphate binding	PFKL PFKM PFKP	4.66e-07	5	73	3	GO:0070095
GeneOntologyMolecularFunction	phosphofructokinase activity	PFKL PFKM PFKP	1.62e-06	7	73	3	GO:0008443
GeneOntologyMolecularFunction	oxalate transmembrane transporter activity	SLC26A8 SLC26A5 SLC26A1	5.52e-06	10	73	3	GO:0019531
GeneOntologyMolecularFunction	secondary active sulfate transmembrane transporter activity	SLC26A8 SLC26A5 SLC26A1	7.57e-06	11	73	3	GO:0008271
GeneOntologyMolecularFunction	sulfate transmembrane transporter activity	SLC26A8 SLC26A5 SLC26A1	2.54e-05	16	73	3	GO:0015116
GeneOntologyMolecularFunction	AMP binding	PFKL PFKM PFKP	5.95e-05	21	73	3	GO:0016208
GeneOntologyMolecularFunction	carbohydrate kinase activity	PFKL PFKM PFKP	5.95e-05	21	73	3	GO:0019200
GeneOntologyMolecularFunction	dicarboxylic acid transmembrane transporter activity	SLC26A8 SLC26A5 SLC26A1	1.96e-04	31	73	3	GO:0005310
GeneOntologyMolecularFunction	fructose binding	PFKL PFKM	1.96e-04	6	73	2	GO:0070061
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC26A8 SLC26A5 SLC26A1	2.15e-04	32	73	3	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC26A8 SLC26A5 SLC26A1	2.15e-04	32	73	3	GO:0005452
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	SLC26A8 SLC26A5 SLC26A1	1.45e-03	61	73	3	GO:1901682
GeneOntologyMolecularFunction	antiporter activity	SLC26A8 SLC26A5 SLC41A1 SLC26A1	1.64e-03	138	73	4	GO:0015297
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR8H3 OR11L1 TAS2R13 OR8U1 OR4Q2 OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	1.96e-17	485	74	21	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR8H3 OR11L1 OR8U1 OR4Q2 OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	3.55e-17	432	74	20	GO:0050911
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR8H3 OR11L1 TAS2R13 OR8U1 OR4Q2 OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	9.31e-17	524	74	21	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of smell	OR8H3 OR11L1 OR8U1 OR4Q2 OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	1.47e-16	465	74	20	GO:0007608
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR8H3 OR11L1 TAS2R13 OR8U1 OR4Q2 OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	2.20e-16	547	74	21	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR8H3 OR11L1 TAS2R13 OR8U1 OR4Q2 OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	7.60e-16	582	74	21	GO:0050906
GeneOntologyBiologicalProcess	sensory perception	LRIG2 OR8H3 OR11L1 TAS2R13 OR8U1 OR4Q2 OTOGL OR6C76 OR52H1 SLC26A5 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 GRM7 OR10Z1 OR8U9 OR2A2 OR1D2	1.81e-14	1072	74	25	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus	OR8H3 OR11L1 TAS2R13 OR8U1 OR4Q2 OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	5.30e-14	722	74	21	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR8H3 OR11L1 TAS2R13 OR8U1 OR4Q2 MLNR OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 GRM7 OR10Z1 OR8U9 OR2A2 OR1D2	3.01e-10	1395	74	23	GO:0007186
GeneOntologyBiologicalProcess	fructose 1,6-bisphosphate metabolic process	PFKL PFKM PFKP	3.67e-06	9	74	3	GO:0030388
GeneOntologyBiologicalProcess	oxalate transport	SLC26A8 SLC26A5 SLC26A1	9.53e-06	12	74	3	GO:0019532
GeneOntologyBiologicalProcess	sulfate transmembrane transport	SLC26A8 SLC26A5 SLC26A1	2.40e-05	16	74	3	GO:1902358
GeneOntologyBiologicalProcess	fructose 6-phosphate metabolic process	PFKL PFKM PFKP	2.40e-05	16	74	3	GO:0006002
GeneOntologyBiologicalProcess	canonical glycolysis	PFKL PFKM PFKP	5.63e-05	21	74	3	GO:0061621
GeneOntologyBiologicalProcess	NADH regeneration	PFKL PFKM PFKP	5.63e-05	21	74	3	GO:0006735
GeneOntologyBiologicalProcess	glucose catabolic process to pyruvate	PFKL PFKM PFKP	5.63e-05	21	74	3	GO:0061718
GeneOntologyBiologicalProcess	organophosphate catabolic process	ENTPD5 PDXP PFKL PFKM PFKP PTEN NCF1B	6.67e-05	281	74	7	GO:0046434
GeneOntologyBiologicalProcess	pyridine-containing compound catabolic process	PDXP PFKL PFKM PFKP NCF1B	8.06e-05	123	74	5	GO:0072526
GeneOntologyBiologicalProcess	glycolytic process through glucose-6-phosphate	PFKL PFKM PFKP	9.63e-05	25	74	3	GO:0061620
GeneOntologyBiologicalProcess	NAD catabolic process	PFKL PFKM PFKP	9.63e-05	25	74	3	GO:0019677
GeneOntologyBiologicalProcess	glycolytic process through fructose-6-phosphate	PFKL PFKM PFKP	1.85e-04	31	74	3	GO:0061615
GeneOntologyBiologicalProcess	glucose catabolic process	PFKL PFKM PFKP	2.04e-04	32	74	3	GO:0006007
GeneOntologyBiologicalProcess	bicarbonate transport	SLC26A8 SLC26A5 SLC26A1	3.42e-04	38	74	3	GO:0015701
GeneOntologyBiologicalProcess	NADH metabolic process	PFKL PFKM PFKP	4.60e-04	42	74	3	GO:0006734
GeneOntologyBiologicalProcess	MDA-5 signaling pathway	DDX60 IRF3	6.84e-04	11	74	2	GO:0039530
GeneOntologyBiologicalProcess	pyridine nucleotide catabolic process	PFKL PFKM PFKP NCF1B	8.88e-04	119	74	4	GO:0019364
GeneOntologyBiologicalProcess	nucleotide catabolic process	ENTPD5 PFKL PFKM PFKP NCF1B	9.11e-04	208	74	5	GO:0009166
GeneOntologyBiologicalProcess	hexose catabolic process	PFKL PFKM PFKP	9.13e-04	53	74	3	GO:0019320
GeneOntologyBiologicalProcess	dicarboxylic acid transport	SLC26A8 SLC26A5 GRM7 SLC26A1	9.16e-04	120	74	4	GO:0006835
GeneOntologyBiologicalProcess	ribonucleoside diphosphate catabolic process	ENTPD5 PFKL PFKM PFKP	9.45e-04	121	74	4	GO:0009191
GeneOntologyBiologicalProcess	pyridine-containing compound metabolic process	PDXP PFKL PFKM PFKP NCF1B	9.50e-04	210	74	5	GO:0072524
GeneOntologyBiologicalProcess	nucleoside diphosphate catabolic process	ENTPD5 PFKL PFKM PFKP	1.03e-03	124	74	4	GO:0009134
GeneOntologyBiologicalProcess	nucleoside phosphate catabolic process	ENTPD5 PFKL PFKM PFKP NCF1B	1.08e-03	216	74	5	GO:1901292
GeneOntologyBiologicalProcess	monosaccharide catabolic process	PFKL PFKM PFKP	1.13e-03	57	74	3	GO:0046365
GeneOntologyCellularComponent	6-phosphofructokinase complex	PFKL PFKM PFKP	4.26e-08	3	74	3	GO:0005945
MousePheno	skeletal muscle degeneration	COQ8A CAPN3 PFKM KLHL31	2.42e-06	30	45	4	MP:0009415
MousePheno	muscle degeneration	COQ8A CAPN3 PFKM KLHL31	2.83e-05	55	45	4	MP:0000749
MousePheno	skeletal muscle fiber degeneration	COQ8A PFKM KLHL31	3.98e-05	21	45	3	MP:0009412
Domain	Olfact_rcpt	OR8H3 OR11L1 OR8U1 OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	3.79e-15	393	70	18	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR8H3 OR11L1 OR8U1 MLNR OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	3.09e-12	670	70	19	IPR017452
Domain	7tm_1	OR8H3 OR11L1 OR8U1 MLNR OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	3.70e-12	677	70	19	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR8H3 OR11L1 OR8U1 MLNR OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	4.54e-12	685	70	19	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8H3 OR11L1 OR8U1 MLNR OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	5.29e-12	691	70	19	PS50262
Domain	GPCR_Rhodpsn	OR8H3 OR11L1 OR8U1 MLNR OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	5.42e-12	692	70	19	IPR000276
Domain	PHOSPHOFRUCTOKINASE	PFKL PFKM PFKP	5.04e-08	3	70	3	PS00433
Domain	6-Pfructokinase_euk	PFKL PFKM PFKP	5.04e-08	3	70	3	IPR009161
Domain	Phosphofructokinase_CS	PFKL PFKM PFKP	5.04e-08	3	70	3	IPR015912
Domain	PFK	PFKL PFKM PFKP	5.04e-08	3	70	3	PF00365
Domain	ATP_PFK	PFKL PFKM PFKP	5.04e-08	3	70	3	IPR022953
Domain	Phosphofructokinase_dom	PFKL PFKM PFKP	5.04e-08	3	70	3	IPR000023
Domain	SLC26A	SLC26A8 SLC26A5 SLC26A1	5.94e-06	10	70	3	PS01130
Domain	STAS	SLC26A8 SLC26A5 SLC26A1	8.14e-06	11	70	3	PS50801
Domain	STAS_dom	SLC26A8 SLC26A5 SLC26A1	8.14e-06	11	70	3	IPR002645
Domain	SLC26A/SulP_dom	SLC26A8 SLC26A5 SLC26A1	8.14e-06	11	70	3	IPR011547
Domain	STAS	SLC26A8 SLC26A5 SLC26A1	8.14e-06	11	70	3	PF01740
Domain	SLC26A/SulP_fam	SLC26A8 SLC26A5 SLC26A1	8.14e-06	11	70	3	IPR001902
Domain	-	SLC26A8 SLC26A5 SLC26A1	8.14e-06	11	70	3	3.30.750.24
Domain	Sulfate_transp	SLC26A8 SLC26A5 SLC26A1	8.14e-06	11	70	3	PF00916
Domain	S04_transporter_CS	SLC26A5 SLC26A1	2.87e-04	7	70	2	IPR018045
Domain	BTB-kelch_protein	KLHL38 KLHL10 KLHL31	5.59e-04	43	70	3	IPR017096
Domain	Kelch	KLHL38 KLHL10 KLHL31	1.34e-03	58	70	3	SM00612
Domain	BACK	KLHL38 KLHL10 KLHL31	1.48e-03	60	70	3	SM00875
Domain	BTB	KLHL38 KLHL10 NACC1 KLHL31	1.48e-03	131	70	4	PF00651
Domain	BACK	KLHL38 KLHL10 KLHL31	1.55e-03	61	70	3	PF07707
Domain	BACK	KLHL38 KLHL10 KLHL31	1.55e-03	61	70	3	IPR011705
Domain	Kelch_1	KLHL38 KLHL10 KLHL31	2.31e-03	70	70	3	PF01344
Domain	Kelch_1	KLHL38 KLHL10 KLHL31	2.31e-03	70	70	3	IPR006652
Domain	BTB	KLHL38 KLHL10 NACC1 KLHL31	3.07e-03	160	70	4	PS50097
Domain	EF-hand_5	CAPN3 PLCD4	3.93e-03	25	70	2	PF13202
Domain	-	KLHL10 KLHL31	4.57e-03	27	70	2	2.130.10.80
Domain	BTB	KLHL38 KLHL10 NACC1 KLHL31	4.66e-03	180	70	4	SM00225
Domain	BTB/POZ_dom	KLHL38 KLHL10 NACC1 KLHL31	5.14e-03	185	70	4	IPR000210
Domain	SKP1/BTB/POZ	KLHL38 KLHL10 NACC1 KLHL31	5.54e-03	189	70	4	IPR011333
Domain	Gal_Oxidase_b-propeller	KLHL10 KLHL31	7.19e-03	34	70	2	IPR015916
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR8H3 OR11L1 OR8U1 OR4Q2 OR6C76 OR52H1 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	3.43e-16	417	61	20	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR8H3 OR11L1 TAS2R13 OR8U1 OR4Q2 OTOGL OR6C76 OR52H1 SLC26A5 OR52E1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR8U9 OR2A2 OR1D2	5.67e-16	636	61	23	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR8H3 OR11L1 OR8U1 OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR2A2 OR1D2	3.90e-13	389	61	17	M14091
Pathway	BIOCARTA_PTDINS_PATHWAY	PFKL PFKM PFKP	1.28e-04	23	61	3	M8809
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOLYSIS	PFKL PFKM PFKP	1.66e-04	25	61	3	M47623
Pathway	KEGG_GALACTOSE_METABOLISM	PFKL PFKM PFKP	1.87e-04	26	61	3	M4377
Pathway	KEGG_PENTOSE_PHOSPHATE_PATHWAY	PFKL PFKM PFKP	2.09e-04	27	61	3	M1386
Pathway	KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM	PFKL PFKM PFKP	4.19e-04	34	61	3	M15898
Pathway	REACTOME_GLUCOSE_METABOLISM	NUP210 PFKL PFKM PFKP	4.31e-04	82	61	4	MM15394
Pathway	REACTOME_GLUCOSE_METABOLISM	NUP210 PFKL PFKM PFKP	4.95e-04	85	61	4	M1870
Pathway	WP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS	PFKL PFKM PFKP PTEN	5.17e-04	86	61	4	M39375
Pathway	WP_GPCRS_OTHER	OR8U1 OR2W1 OR2AG2 OR1D2	7.83e-04	96	61	4	MM15939
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR8H3 OR11L1 OR8U1 OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR4D11 OR8U3 OR10Z1 OR2A2 OR1D2	1.97e-17	340	74	16	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR8H3 OR11L1 OR8U1 OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR4D11 OR8U3 OR10Z1 OR2A2 OR1D2	1.97e-17	340	74	16	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR8H3 OR11L1 OR8U1 OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR4D11 OR8U3 OR10Z1 OR2A2 OR1D2	2.26e-17	343	74	16	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR8H3 OR11L1 OR8U1 OR6C76 OR52H1 OR5C1 OR5B21 OR2W1 OR2AG2 OR2D2 OR4D6 OR4D11 OR8U3 OR10Z1 OR2A2 OR1D2	2.60e-17	346	74	16	14611657
Pubmed	The human olfactory receptor gene family.	OR8H3 OR11L1 OR4Q2 OR52H1 OR5C1 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR8U3 OR10Z1 OR2A2 OR1D2	4.90e-13	541	74	15	14983052
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR4Q2 OR2W1 OR2AG2 OR2D2 OR4D6 OR2B3 OR4D11 OR2A2 OR1D2	1.02e-09	219	74	9	12213199
Pubmed	Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.	PFKL PFKM PFKP	9.25e-09	3	74	3	33141153
Pubmed	Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues.	PFKL PFKM PFKP	9.25e-09	3	74	3	156693
Pubmed	Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.	PFKL PFKM PFKP	9.25e-09	3	74	3	7825568
Pubmed	Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system.	PFKL PFKM PFKP	9.25e-09	3	74	3	6451249
Pubmed	Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system.	PFKL PFKM PFKP	9.25e-09	3	74	3	6444721
Pubmed	Genomic organization, 5'flanking region and tissue-specific expression of mouse phosphofructokinase C gene.	PFKL PFKM PFKP	9.25e-09	3	74	3	11137296
Pubmed	Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII.	PFKL PFKM PFKP	9.25e-09	3	74	3	2960695
Pubmed	Phosphofructokinase isozyme expression during myoblast differentiation.	PFKL PFKM PFKP	9.25e-09	3	74	3	2521854
Pubmed	Physiological roles and regulation of mammalian sulfate transporters.	SLC26A8 SLC26A5 SLC26A1	7.70e-07	9	74	3	11581495
Pubmed	N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins.	SLC26A8 SLC26A5 SLC26A1	1.10e-06	10	74	3	24647542
Pubmed	Insulin specifically regulates expression of liver and muscle phosphofructokinase isoforms.	PFKL PFKM	4.47e-06	2	74	2	29655163
Pubmed	Cloning of human muscle phosphofructokinase cDNA.	PFKM PFKP	4.47e-06	2	74	2	2822475
Pubmed	Lack of PTEN in osteocytes increases circulating phosphate concentrations by decreasing intact fibroblast growth factor 23 levels.	FGF23 PTEN	4.47e-06	2	74	2	33299044
Pubmed	Isozyme analysis of human polymorphonuclear leukocyte phosphofructokinase from insulin resistant individuals.	PFKL PFKM	4.47e-06	2	74	2	8780720
Pubmed	The tumor suppressor PTEN has a critical role in antiviral innate immunity.	IRF3 PTEN	4.47e-06	2	74	2	26692175
Pubmed	The molecular mechanism of the inherited phosphofructokinase deficiency associated with hemolysis and myopathy.	PFKL PFKM	4.47e-06	2	74	2	6444532
Pubmed	The glycolytic enzyme phosphofructokinase-1 assembles into filaments.	PFKL PFKM	4.47e-06	2	74	2	28646105
Pubmed	Chimeric phosphofructokinases involving exchange of the N- and C-terminal halves of mammalian isozymes: implications for ligand binding sites.	PFKM PFKP	4.47e-06	2	74	2	17544406
Pubmed	Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.	PFKM PFKP	4.47e-06	2	74	2	25985179
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	LRIG2 POLR2B NUP210 FASTKD5 PFKL PFKM PFKP GCN1 ARAF	6.18e-06	613	74	9	22268729
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	PFKL PFKM PFKP ARAF	7.34e-06	58	74	4	31067491
Pubmed	Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching.	PFKL PFKM PFKP	7.37e-06	18	74	3	28049690
Pubmed	PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy.	PTEN GRM7	2.67e-05	4	74	2	25369768
Pubmed	PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons.	PTEN GRM7	2.67e-05	4	74	2	20525971
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	COQ8A MPDU1 NUP210 SEC22B PFKP GCN1	3.14e-05	282	74	6	35007762
Pubmed	Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis.	PFKM PFKP	6.66e-05	6	74	2	29038421
Pubmed	Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger.	SLC26A5 SLC26A1	6.66e-05	6	74	2	11087667
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL38 KLHL10 KLHL31	9.30e-05	41	74	3	23676014
Pubmed	The diploid genome sequence of an individual human.	OR8U1 OR8U9	1.24e-04	8	74	2	17803354
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	POLR2B NUP210 PFKL GCN1	1.29e-04	120	74	4	27320910
Pubmed	Genomic analysis of orthologous mouse and human olfactory receptor loci.	OR2AG2 OR2D2	1.59e-04	9	74	2	11416212
Pubmed	Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.	PFKL PFKM	1.59e-04	9	74	2	21074528
Pubmed	GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.	MBOAT1 PFKM	1.99e-04	10	74	2	25199915
Pubmed	Common variation contributes to the genetic architecture of social communication traits.	OR2W1 OR2B3	1.99e-04	10	74	2	24047820
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	LRIG2 NUP210 SEC22B PFKM PFKP PTEN WDR26 GCN1 ARAF	2.21e-04	974	74	9	28675297
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	COQ8A DDX60 POLR2B NUP210 FASTKD5 SEC22B PFKL PFKM PFKP WDR26 GCN1	2.25e-04	1440	74	11	30833792
Pubmed	MRE11 complex links RECQ5 helicase to sites of DNA damage.	POLR2B RECQL4	2.43e-04	11	74	2	19270065
Pubmed	Identification of ligands for olfactory receptors by functional expression of a receptor library.	OR8U1 OR2W1	2.91e-04	12	74	2	9875846
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	COQ8A POLR2B NUP210 FASTKD5 SEC22B PFKL PFKM PFKP WDR26 GCN1	3.23e-04	1257	74	10	37317656
Pubmed	Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.	IRF3 NCF1B	3.43e-04	13	74	2	18423196
Pubmed	Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.	PFKL PFKP GCN1	3.51e-04	64	74	3	22865885
Pubmed	An analysis of expression patterns of genes encoding proteins with catalytic activities.	PFKL PFKM PFKP	4.02e-04	67	74	3	17626619
Pubmed	The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.	ABHD17A POLR2B MKRN2	4.02e-04	67	74	3	22046132
Pubmed	Defining human ERAD networks through an integrative mapping strategy.	SEC22B PFKL PFKP GCN1	5.19e-04	173	74	4	22119785
Pubmed	Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.	ENTPD5 GSDMB	5.26e-04	16	74	2	20601676
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	PFKL PFKP WDR26 GCN1	6.40e-04	183	74	4	23956138
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	PFKM PFKP GCN1	6.51e-04	79	74	3	26446488
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	COQ8A SEC22B ARAF	1.44e-03	104	74	3	31240132
Pubmed	Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.	IRF3 PTEN	1.51e-03	27	74	2	32428860
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	POLR2B FASTKD5 PFKP GCN1	1.67e-03	237	74	4	29564676
Pubmed	Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.	POLR2B FASTKD5 GCN1	1.74e-03	111	74	3	32683582
Pubmed	Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.	TAS2R13 GRM7	1.87e-03	30	74	2	17273929
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	PFKL GCN1	1.87e-03	30	74	2	32867711
Pubmed	Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.	PFKM ARAF	1.87e-03	30	74	2	34017080
Pubmed	Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.	GSDMB WDR26	1.87e-03	30	74	2	11483580
Pubmed	Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.	PFKL PFKM PFKP	1.88e-03	114	74	3	28245920
Pubmed	Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.	CILP CAPN3	2.00e-03	31	74	2	16140986
Pubmed	Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress.	FGF23 NCF1B	2.00e-03	31	74	2	38395995
Pubmed	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.	POLR2B RECQL4	2.00e-03	31	74	2	32355176
Pubmed	A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.	ABHD17A NCF1B	2.00e-03	31	74	2	32245826
Pubmed	Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.	PFKL PFKM PFKP	2.02e-03	117	74	3	18996102
Interaction	BCL2L14 interactions	COQ8A POLR2B FASTKD5 PFKL PFKM PFKP GCN1	8.68e-08	127	59	7	int:BCL2L14
Interaction	FLT3 interactions	FBXL13 OR8U1 COQ8A NUP210 SEC22B PFKL PFKM GCN1	3.88e-06	318	59	8	int:FLT3
Interaction	FBXO6 interactions	LRIG2 POLR2B NUP210 ENTPD5 IRF3 FASTKD5 PFKL PFKM PFKP GCN1 ARAF	6.31e-06	717	59	11	int:FBXO6
Cytoband	11q12.1	OR8H3 OR8U1 OR5B21 OR4D6 OR4D11 OR8U3	2.58e-07	161	74	6	11q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	OR8H3 OR8U1 OR5B21 OR4D6 OR4D11 OR8U3 CYB561A3	1.49e-06	345	74	7	chr11q12
Cytoband	11p15.4	OR52H1 OR52E1 OR2AG2 OR2D2	3.17e-04	200	74	4	11p15.4
Cytoband	1q42.13	COQ8A WDR26	2.87e-03	49	74	2	1q42.13
GeneFamily	Olfactory receptors, family 2	OR2W1 OR2AG2 OR2D2 OR2B3 OR2A2	3.07e-05	113	58	5	149
GeneFamily	Kelch like\|BTB domain containing	KLHL38 KLHL10 KLHL31	3.29e-04	42	58	3	617
GeneFamily	Olfactory receptors, family 8	OR8H3 OR8U1 OR8U9	5.20e-04	49	58	3	155
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL38 KLHL10 NACC1 KLHL31	8.98e-04	134	58	4	861
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COQ8A CAPN3 PLCD4 PFKM KLHL31	9.92e-06	174	73	5	4a6e04b4f12b87c15fa1409989cbe32c43736369
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COQ8A CAPN3 PLCD4 PFKM KLHL31	1.23e-05	182	73	5	edfc598b7199ca1d8a399b264ab863c299b1eede
ToppCell	Frontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Ccnd1_(Mural.Rgs5Acta2.Ccnd1)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KLHL38 OTOGL CYB561A3 KLHL31	1.40e-05	89	73	4	42432936a6b4289cc4b42fcb576fb09073f2264b
ToppCell	Frontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Ccnd1_(Mural.Rgs5Acta2.Ccnd1)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KLHL38 OTOGL CYB561A3 KLHL31	1.40e-05	89	73	4	6c594e13f169970b337c2fc3ab969faf6db1a27a
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL38 COQ8A PLCD4 PFKM KLHL31	1.48e-05	189	73	5	d2b008f98739c6af7ee63b643011a240db20e4d8
Drug	Uridine diphosphate 2-deoxyglucose	PFKL PFKM PFKP	1.16e-07	4	71	3	CID000165519
Drug	AC1MIX9B	PFKL PFKM PFKP	5.77e-07	6	71	3	CID003081623
Drug	glipentide	PFKL PFKM PFKP	1.01e-06	7	71	3	CID000065779
Drug	dactylarin	PFKL PFKM PFKP	1.01e-06	7	71	3	CID000161389
Drug	AC1Q6RZ6	SLC22A16 PDXP PFKL PFKM GCN1	1.22e-06	60	71	5	CID000000609
Drug	fructose 2-phosphorothioate 6-phosphate	PFKL PFKM PFKP	4.71e-06	11	71	3	CID000195184
Drug	C14:1n-5	PFKL PFKM PFKP	4.71e-06	11	71	3	CID000068344
Drug	riboxin	ENTPD5 PFKL PFKM PFKP	4.74e-06	36	71	4	CID000006831
Drug	UDP - Na	NPC1L1 ENTPD5 PFKL PFKM PFKP ARID5A ARAF	8.66e-06	235	71	7	CID000001158
Drug	2,3,5-tri-O-benzyl-D-arabinofuranose	PFKL PFKM	9.59e-06	2	71	2	CID000255457
Drug	M 16209	PFKL PFKM PFKP	1.29e-05	15	71	3	CID000164260
Drug	dibenzyl succinate	PFKL PFKM PFKP	1.58e-05	16	71	3	CID000007653
Drug	AC1L494B	SLC22A16 PFKL PFKM PFKP	2.26e-05	53	71	4	CID000181487
Drug	AC1L1AO2	PFKL PFKM PFKP	2.29e-05	18	71	3	CID000001073
Drug	BRL 26830A	PFKL PFKM PFKP	2.72e-05	19	71	3	CID006438331
Drug	netropsin	POLR2B PFKL PFKM PFKP	2.82e-05	56	71	4	CID000004461
Drug	AC1L977H	PFKL PFKM	2.87e-05	3	71	2	CID000439366
Drug	AC1L7EWQ	MMD ARAF	2.87e-05	3	71	2	CID000359588
Drug	d-sedoheptulose 1,7-diphosphate	PFKL PFKM PFKP	4.29e-05	22	71	3	CID000001193
Drug	mitiglinide	CAPN3 PFKL PFKM	8.06e-05	27	71	3	CID000121891
Drug	emodin anthrone	CYB561A3 ARAF	9.53e-05	5	71	2	CID000122635
Drug	1-o-phosphonohex-2-ulose	PFKL PFKM PFKP	1.00e-04	29	71	3	CID000000481
Drug	2,5-anhydro-D-mannitol	PFKL PFKM PFKP	1.23e-04	31	71	3	CID000001494
Drug	Tenax	PFKL PFKM PFKP	1.48e-04	33	71	3	CID000122082
Drug	phosphonate analog	PFKL PFKM PFKP	1.48e-04	33	71	3	CID000475766
Drug	2-hexulofuranose	CAPN3 PFKL PFKM PFKP	1.66e-04	88	71	4	CID000000716
Disease	glycogen storage disease (implicated_via_orthology)	PFKL PFKM PFKP	4.67e-08	4	68	3	DOID:2747 (implicated_via_orthology)
Disease	disease of metabolism (implicated_via_orthology)	PFKL PFKM PFKP PTEN	1.50e-07	21	68	4	DOID:0014667 (implicated_via_orthology)
Disease	HbA1c measurement	SLC22A16 MPDU1 MKRN2 PFKL PFKM PFKP PTEN WDR26 OR10Z1	2.41e-05	675	68	9	EFO_0004541
Disease	hemoglobin A1 measurement	SLC22A16 PFKL PFKM PFKP PTEN WDR26	1.26e-03	520	68	6	EFO_0007629
Disease	Glycogen Storage Disease	PFKL PFKM	1.77e-03	27	68	2	C0017919
Disease	sensory perception of smell	OR8H3 OR4D6	2.04e-03	29	68	2	GO_0007608

Protein segments in the cluster

Peptide	Gene	Start	Entry
LFGHRCGMTTVLTLT	BARGIN	626	Q6ZT62
RLLSSFYCKGTHGIM	ARID5A	241	Q03989
MRGLVGCISHFTLST	EGFLAM	981	Q63HQ2
FFGCRHYTTGLTLMD	GSDMB	46	Q8TAX9
QMSSFYIGLGSRLHC	ABHD17A	126	Q96GS6
ITCRYFMHGVCREGS	MKRN2	6	Q9H000
TALGQYFCSITMHRL	NUP210	1636	Q8TEM1
TYGEHMGIARLSCAS	OR52E1	176	Q8NGJ3
HYVTIMSRGQCTALI	OR4D11	131	Q8NGI4
CSSHLIVVGMFYGAA	OR2AG2	241	A6NM03
CGSHMIVVSLFYGTA	OR2B3	241	O76000
RPLHYTTTMTAGVCA	OR5B21	126	A6NL26
HCAVTLSDRVYVMGG	KLHL31	506	Q9H511
IMFDAGSTGTRIHVY	ENTPD5	51	O75356
VFSHDAYMCTLISRG	MED12L	611	Q86YW9
TSCSLSLRMYHRFLG	DDX60	266	Q8IY21
MLALAGTYRCYGSVT	KIR3DL1	186	P43629
LSGVICGFMHVIATF	OR14L1P	151	Q8NHC6
CGSHLTVVSMFYGTI	OR2W1	241	Q9Y3N9
LHYTTVMSRGLCCVL	OR4Q2	131	P0C623
RTFVLEVMGRHCGYL	PFKL	201	P17858
RTFVLEVMGRHCGYL	PFKM	201	P08237
EVMGRHCGYLALVTS	PFKM	206	P08237
TFVLEVMGRHCGYLA	PFKP	211	Q01813
YAGMLGLLVQFCTSH	GCN1	196	Q92616
CGSHLAVVTLYYGTM	OR11L1	241	Q8NGX0
SYGFIAGAVIHMRSV	OR5C1	221	Q8NGR4
GSYTVILVMLRSHSG	OR4D6	216	Q8NGJ1
HVIVVSISYGSCIFM	OR6C76	241	A6NM76
CGSHMLAVTIFYGTL	OR8U9	241	P0C7N5
HQGTLTEYCGTLMSL	NCF1B	91	A6NI72
GMGLCALFIVSTVFH	MMD	66	Q15546
CVSHLLGVTIFYGTM	OR8H3	241	Q8N146
GLGMTLVIFHLSFCS	OR10Z1	156	Q8NGY1
SSHLCVVGLFFGIAM	OR2A2	241	Q6IF42
CGSHLMVVILFYGSA	OR2D2	241	Q9H210
LFGVSLYSMCHISVG	NPC1L1	856	Q9UHC9
ELMTGSLPYSHIGCR	ARAF	501	P10398
QGVMHLTLYCSALRF	FASTKD5	391	Q7L8L6
PMHSRRCYVSVTVLG	KLHL10	371	Q6JEL2
AAHCISSSGIYRVML	CELA2B	71	P08218
GFVVITGVMSRRYLC	FGF23	81	Q9GZV9
TYSLHRKMGGSFLIC	COQ8A	606	Q8NI60
MLTYCLFVHASSRGF	CATIP	81	Q7Z7H3
GFRYIANSCTGIMHL	FBXL13	341	Q8NEE6
FFVAMGYLTICHISR	MBOAT1	111	Q6ZNC8
SFRRVFLGLGMCISY	GRM7	656	Q14831
MTLTCHVEGGTRLAY	HEPACAM2	166	A8MVW5
MVSGRFYLSCLLLGS	CYB561A3	1	Q8NBI2
MACGLVRGHAYSVTG	CAPN3	326	P20807
RCTLEAGAMTFHYII	SEC22B	51	O75396
YVGEGCTYATLLHMT	MLNR	116	O43193
GRHYSFIGMCQYILV	OTOGL	496	Q3ZCN5
TGVMICAYLLHRGKF	PTEN	131	P60484
GVMSYVRHVLSCLGG	IRF3	256	Q14653
GLIHTLLMTRVTFCG	OR1D2	156	P34982
LGTCGSHVCVILMFY	OR52H1	246	Q8NGJ2
CGSHMLAVTIFYGTL	OR8U1	241	Q8NH10
HYLAIFVSGTGLRIM	TAS2R13	71	Q9NYV9
RHVLSMDGFLSYLCS	PLCD4	261	Q9BRC7
RMGVHCFLGLTATAT	RECQL4	631	O94761
NISCGIHYLASVFMG	SLC22A16	31	Q86VW1
IYVIFGSCHQMSIGS	SLC26A8	136	Q96RN1
IMYCFLGTSRHISIG	SLC26A5	121	P58743
LCGIMAIANTRTHTY	POLR2B	1121	P30876
LVFLYTISCMQGGHT	SLC41A1	421	Q8IVJ1
CGSHMVTVTIFYGTL	OR8U3	241	Q8NH85
LQTITICFLVMHYRG	MPDU1	111	O75352
FGHRCGMTTVLTLTG	PDXP	246	Q96GD0
RVSMTGYKGTFTLHV	CILP	516	O75339
MACYLVISSRHLSNG	ZNF804B	1	A4D1E1
IYFLMGTSRHVSVGI	SLC26A1	111	Q9H2B4
NTERIHVLSGYLMCS	WDR26	246	Q9H7D7
MGHSSLNCYIRVDTG	ZNF44	161	P15621
SAITLHRSIYVLGGM	KLHL38	326	Q2WGJ6
CIMSNTLGTERGHIY	LRIG2	766	O94898
ILSFCYTGRLSMNVG	NACC1	81	Q96RE7