Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	methionine adenosyltransferase activity	MAT1A MAT2A	1.04e-05	2	65	2	GO:0004478
GeneOntologyMolecularFunction	spectrin binding	ANK2 CAMSAP3 CAMSAP1	1.83e-04	34	65	3	GO:0030507
GeneOntologyBiologicalProcess	intracellular transport	NOLC1 RGPD2 SH3TC2 TBC1D10B NEUROD1 RAB4B GNPTAB SYNE2 CAMSAP3 RGPD1 NUP133 DENND1C SEC31A HEATR5B SEC31B GFAP	1.17e-05	1496	65	16	GO:0046907
GeneOntologyBiologicalProcess	S-adenosylmethionine biosynthetic process	MAT1A MAT2A	5.84e-05	4	65	2	GO:0006556
GeneOntologyBiologicalProcess	modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	SYNE2 SRGAP2	9.72e-05	5	65	2	GO:0021815
GeneOntologyBiologicalProcess	negative regulation of protein localization to microtubule	ABHD17B ABHD17C	9.72e-05	5	65	2	GO:1902817
GeneOntologyBiologicalProcess	regulation of protein localization to microtubule	ABHD17B ABHD17C	9.72e-05	5	65	2	GO:1902816
GeneOntologyCellularComponent	methionine adenosyltransferase complex	MAT1A MAT2A	2.94e-05	3	66	2	GO:0048269
GeneOntologyCellularComponent	microtubule minus-end	CAMSAP3 CAMSAP1	2.04e-04	7	66	2	GO:0036449
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD2 RGPD1	2.72e-04	8	66	2	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD2 RGPD1	4.35e-04	10	66	2	GO:0044614
GeneOntologyCellularComponent	microbody lumen	ACOT2 HAO1 ACOX3	7.01e-04	55	66	3	GO:0031907
GeneOntologyCellularComponent	peroxisomal matrix	ACOT2 HAO1 ACOX3	7.01e-04	55	66	3	GO:0005782
GeneOntologyCellularComponent	annulate lamellae	RGPD2 RGPD1	8.72e-04	14	66	2	GO:0005642
GeneOntologyCellularComponent	COPII vesicle coat	SEC31A SEC31B	1.14e-03	16	66	2	GO:0030127
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD2 RGPD1	1.45e-03	18	66	2	GO:0044615
Domain	S-AdoMet_synt_M	MAT1A MAT2A	1.23e-05	2	66	2	PF02772
Domain	S-AdoMet_synt_C	MAT1A MAT2A	1.23e-05	2	66	2	PF02773
Domain	ADOMET_SYNTHASE_CS	MAT1A MAT2A	1.23e-05	2	66	2	IPR022631
Domain	S-AdoMet_synt_C	MAT1A MAT2A	1.23e-05	2	66	2	IPR022630
Domain	S-AdoMet_synthetase_sfam	MAT1A MAT2A	1.23e-05	2	66	2	IPR022636
Domain	S-AdoMet_synt_N	MAT1A MAT2A	1.23e-05	2	66	2	PF00438
Domain	S-AdoMet_synt_central	MAT1A MAT2A	1.23e-05	2	66	2	IPR022629
Domain	S-AdoMet_synt_N	MAT1A MAT2A	1.23e-05	2	66	2	IPR022628
Domain	S-AdoMet_synthetase	MAT1A MAT2A	1.23e-05	2	66	2	IPR002133
Domain	ADOMET_SYNTHASE_1	MAT1A MAT2A	1.23e-05	2	66	2	PS00376
Domain	ADOMET_SYNTHASE_2	MAT1A MAT2A	1.23e-05	2	66	2	PS00377
Domain	CAMSAP_CKK	CAMSAP3 CAMSAP1	3.68e-05	3	66	2	PF08683
Domain	CAMSAP_CC1	CAMSAP3 CAMSAP1	3.68e-05	3	66	2	IPR031372
Domain	CAMSAP_CC1	CAMSAP3 CAMSAP1	3.68e-05	3	66	2	PF17095
Domain	CAMSAP	CAMSAP3 CAMSAP1	3.68e-05	3	66	2	IPR032940
Domain	CAMSAP_CKK	CAMSAP3 CAMSAP1	3.68e-05	3	66	2	SM01051
Domain	CKK	CAMSAP3 CAMSAP1	3.68e-05	3	66	2	PS51508
Domain	PRC_barrel-like	CAMSAP3 CAMSAP1	3.68e-05	3	66	2	IPR011033
Domain	CKK_domain	CAMSAP3 CAMSAP1	3.68e-05	3	66	2	IPR014797
Domain	Neurogenic_DUF	NEUROD1 NEUROD2	7.35e-05	4	66	2	IPR022575
Domain	Neuro_bHLH	NEUROD1 NEUROD2	7.35e-05	4	66	2	PF12533
Domain	TF_bHLH_NeuroD	NEUROD1 NEUROD2	7.35e-05	4	66	2	IPR016637
Domain	GCC2_Rab_bind	RGPD2 RGPD1	2.55e-04	7	66	2	IPR032023
Domain	CAMSAP_CH	CAMSAP3 CAMSAP1	2.55e-04	7	66	2	PF11971
Domain	CAMSAP_CH	CAMSAP3 CAMSAP1	2.55e-04	7	66	2	IPR022613
Domain	Rab_bind	RGPD2 RGPD1	2.55e-04	7	66	2	PF16704
Domain	Cadherin_tail	PCDHGA10 PCDHGA5 PCDHGA2	3.01e-04	37	66	3	PF15974
Domain	Cadherin_CBD	PCDHGA10 PCDHGA5 PCDHGA2	3.01e-04	37	66	3	IPR031904
Domain	Hydrolase_4	ABHD17B ABHD17C	4.36e-04	9	66	2	IPR022742
Domain	Hydrolase_4	ABHD17B ABHD17C	4.36e-04	9	66	2	PF12146
Domain	Cadherin_C	PCDHGA10 PCDHGA5 PCDHGA2	4.38e-04	42	66	3	IPR032455
Domain	Cadherin_C_2	PCDHGA10 PCDHGA5 PCDHGA2	4.38e-04	42	66	3	PF16492
Domain	-	RGPD2 RGPD1	5.43e-04	10	66	2	1.10.220.60
Domain	Grip	RGPD2 RGPD1	6.63e-04	11	66	2	SM00755
Domain	Peptidase_S9	ABHD17B ABHD17C	6.63e-04	11	66	2	PF00326
Domain	GRIP	RGPD2 RGPD1	6.63e-04	11	66	2	PF01465
Domain	Peptidase_S9	ABHD17B ABHD17C	6.63e-04	11	66	2	IPR001375
Domain	Ran_BP1	RGPD2 RGPD1	7.93e-04	12	66	2	PF00638
Domain	GRIP_dom	RGPD2 RGPD1	7.93e-04	12	66	2	IPR000237
Domain	GRIP	RGPD2 RGPD1	7.93e-04	12	66	2	PS50913
Domain	RANBD1	RGPD2 RGPD1	7.93e-04	12	66	2	PS50196
Domain	-	RGPD2 SH3TC2 RGPD1 DELE1 TEX11	8.23e-04	207	66	5	1.25.40.10
Domain	RanBD	RGPD2 RGPD1	9.36e-04	13	66	2	SM00160
Domain	Ran_bind_dom	RGPD2 RGPD1	9.36e-04	13	66	2	IPR000156
Domain	TPR	RGPD2 SH3TC2 RGPD1 TEX11	1.12e-03	129	66	4	SM00028
Domain	TPR_repeat	RGPD2 SH3TC2 RGPD1 TEX11	1.26e-03	133	66	4	IPR019734
Domain	TPR-like_helical_dom	RGPD2 SH3TC2 RGPD1 DELE1 TEX11	1.39e-03	233	66	5	IPR011990
Domain	Cadherin_2	PCDHGA10 PCDHGA5 PCDHGA2	1.57e-03	65	66	3	PF08266
Domain	Cadherin_N	PCDHGA10 PCDHGA5 PCDHGA2	1.57e-03	65	66	3	IPR013164
Domain	CH	SYNE2 CAMSAP3 CAMSAP1	2.20e-03	73	66	3	PS50021
Domain	CH-domain	SYNE2 CAMSAP3 CAMSAP1	2.37e-03	75	66	3	IPR001715
Domain	TPR_REGION	RGPD2 SH3TC2 RGPD1 DELE1	2.77e-03	165	66	4	PS50293
Domain	TPR	RGPD2 SH3TC2 RGPD1 DELE1	2.77e-03	165	66	4	PS50005
Domain	Cys-rich_flank_reg_C	TLR10 PXDN CHAD	3.98e-03	90	66	3	IPR000483
Domain	LRRCT	TLR10 PXDN CHAD	3.98e-03	90	66	3	SM00082
Domain	Spectrin_repeat	SYNE2 EVPL	4.70e-03	29	66	2	IPR002017
Domain	SNF2_N	CHD6 INO80	5.70e-03	32	66	2	IPR000330
Domain	Spectrin/alpha-actinin	SYNE2 EVPL	5.70e-03	32	66	2	IPR018159
Pubmed	bHLH gene expression in the Emx2-deficient dentate gyrus reveals defective granule cells and absence of migrating precursors.	NEUROD1 NEUROD2 GFAP	2.45e-06	14	67	3	15084498
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NOLC1 RGPD2 PXDN ANK2 SND1 PCDHGA10 PCDHGA5 PCDHGA2 SYNE2 CAMSAP3 RGPD1 CHD6 NEB	3.19e-06	1442	67	13	35575683
Pubmed	The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion.	NEUROD1 NEUROD2	3.66e-06	2	67	2	11900979
Pubmed	Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.	MAT1A MAT2A	3.66e-06	2	67	2	22318685
Pubmed	S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.	MAT1A MAT2A	3.66e-06	2	67	2	27076759
Pubmed	A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.	MAT1A MAT2A	3.66e-06	2	67	2	29749642
Pubmed	NeuroD2 controls inhibitory circuit formation in the molecular layer of the cerebellum.	NEUROD1 NEUROD2	3.66e-06	2	67	2	30723302
Pubmed	Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.	MAT1A MAT2A	3.66e-06	2	67	2	31234428
Pubmed	Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.	MAT1A MAT2A	3.66e-06	2	67	2	29448301
Pubmed	Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.	MAT1A MAT2A	1.10e-05	3	67	2	23425511
Pubmed	Multiple species of mammalian S-adenosylmethionine synthetase. Partial purification and characterization.	MAT1A MAT2A	1.10e-05	3	67	2	7213623
Pubmed	Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport.	SEC31A SEC31B	1.10e-05	3	67	2	10788476
Pubmed	Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin.	CAMSAP3 CAMSAP1	1.10e-05	3	67	2	24706919
Pubmed	Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade.	NEUROD1 NEUROD2	1.10e-05	3	67	2	17924961
Pubmed	Structure and function study of the complex that synthesizes S-adenosylmethionine.	MAT1A MAT2A	1.10e-05	3	67	2	25075345
Pubmed	Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†.	MAT1A MAT2A	1.10e-05	3	67	2	30265288
Pubmed	NeuroD1 is an upstream regulator of NSCL1.	NEUROD1 NEUROD2	1.10e-05	3	67	2	22310718
Pubmed	The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins.	CAMSAP3 CAMSAP1	1.10e-05	3	67	2	19508979
Pubmed	NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.	NEUROD1 NEUROD2	1.10e-05	3	67	2	8816493
Pubmed	NeuroD factors regulate cell fate and neurite stratification in the developing retina.	NEUROD1 NEUROD2	2.19e-05	4	67	2	21593321
Pubmed	ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization.	ABHD17B ABHD17C	2.19e-05	4	67	2	26701913
Pubmed	The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis.	NEUROD1 SRGAP2	2.19e-05	4	67	2	19737524
Pubmed	The Growth arrest specific 1 (Gas1) gene is transcriptionally regulated by NeuroD1 via two distal E-boxes.	NEUROD1 NEUROD2	2.19e-05	4	67	2	29395133
Pubmed	Regulation of neuroD2 expression in mouse brain.	NEUROD1 NEUROD2	2.19e-05	4	67	2	14697366
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	KDM5B NEUROD2 ANK2 USP11 MAT2A GNPTAB CHD6 SRGAP2 SEC31A SEC31B GFAP	3.23e-05	1285	67	11	35914814
Pubmed	Expression pattern of mUBPy in the brain and sensory organs of mouse during embryonic development.	NEUROD1 GFAP	3.64e-05	5	67	2	20633544
Pubmed	Wdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules.	CAMSAP3 CAMSAP1	3.64e-05	5	67	2	34608154
Pubmed	Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.	CAMSAP3 CAMSAP1	3.64e-05	5	67	2	24486153
Pubmed	Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization.	ABHD17B ABHD17C	3.64e-05	5	67	2	28521134
Pubmed	Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system.	NEUROD1 GFAP	3.64e-05	5	67	2	20667107
Pubmed	BETA2/NeuroD1 null mice: a new model for transcription factor-dependent photoreceptor degeneration.	NEUROD1 GFAP	5.46e-05	6	67	2	12533605
Pubmed	The mouse chondroadherin gene: characterization and chromosomal localization.	NEUROD2 CHAD	5.46e-05	6	67	2	9465299
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RGPD2 RGPD1 NUP133	5.49e-05	38	67	3	12791264
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD2 RGPD1	7.63e-05	7	67	2	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD2 RGPD1	7.63e-05	7	67	2	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD2 RGPD1	7.63e-05	7	67	2	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD2 RGPD1	7.63e-05	7	67	2	9037092
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD2 RGPD1	7.63e-05	7	67	2	8603673
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD2 RGPD1	7.63e-05	7	67	2	15710750
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD2 RGPD1	7.63e-05	7	67	2	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD2 RGPD1	7.63e-05	7	67	2	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD2 RGPD1	7.63e-05	7	67	2	23818861
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD2 RGPD1	7.63e-05	7	67	2	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD2 RGPD1	7.63e-05	7	67	2	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD2 RGPD1	7.63e-05	7	67	2	38838144
Pubmed	Wdr47 Controls Neuronal Polarization through the Camsap Family Microtubule Minus-End-Binding Proteins.	CAMSAP3 CAMSAP1	7.63e-05	7	67	2	32320668
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD2 RGPD1	7.63e-05	7	67	2	23536549
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD2 RGPD1	7.63e-05	7	67	2	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD2 RGPD1	7.63e-05	7	67	2	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD2 RGPD1	7.63e-05	7	67	2	38657106
Pubmed	Temporal and spatial regulation of alpha6 integrin expression during the development of the cochlear-vestibular ganglion.	NEUROD1 GFAP	7.63e-05	7	67	2	17436285
Pubmed	Identification of PSD-95 Depalmitoylating Enzymes.	ABHD17B ABHD17C	7.63e-05	7	67	2	27307232
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD2 RGPD1	7.63e-05	7	67	2	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD2 RGPD1	7.63e-05	7	67	2	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD2 RGPD1	7.63e-05	7	67	2	20682751
Pubmed	A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities.	ACOT2 HAO1 ACOX3	8.55e-05	44	67	3	20178365
Pubmed	The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development.	NEUROD1 NEUROD2	1.02e-04	8	67	2	24084125
Pubmed	Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells.	NEUROD1 GFAP	1.02e-04	8	67	2	18848628
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD2 RGPD1	1.02e-04	8	67	2	22262462
Pubmed	Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.	MAT1A MAT2A	1.02e-04	8	67	2	19158324
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD2 RGPD1	1.02e-04	8	67	2	21670213
Pubmed	Development of the adult neurogenic niche in the hippocampus of mice.	NEUROD1 GFAP	1.02e-04	8	67	2	25999820
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD2 RGPD1	1.02e-04	8	67	2	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD2 RGPD1	1.02e-04	8	67	2	27412403
Pubmed	Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss.	NEUROD1 GFAP	1.02e-04	8	67	2	28837861
Pubmed	E protein dosage influences brain development more than family member identity.	NEUROD2 GFAP	1.02e-04	8	67	2	18214987
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD2 RGPD1	1.02e-04	8	67	2	21310149
Pubmed	RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription.	NOLC1 PXDN SND1	1.26e-04	50	67	3	30413534
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD2 RGPD1	1.30e-04	9	67	2	18394993
Pubmed	The neuronal basic helix-loop-helix transcription factor NSCL-1 is dispensable for normal neuronal development.	NEUROD1 GFAP	1.30e-04	9	67	2	11784856
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD2 RGPD1	1.30e-04	9	67	2	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD2 RGPD1	1.30e-04	9	67	2	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD2 RGPD1	1.30e-04	9	67	2	9733766
Pubmed	Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors.	NEUROD1 GFAP	1.30e-04	9	67	2	11239431
Pubmed	Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins.	NEUROD1 NEUROD2	1.30e-04	9	67	2	28130357
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD2 RGPD1	1.30e-04	9	67	2	28100513
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD2 RGPD1	1.30e-04	9	67	2	28877029
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD2 RGPD1	1.30e-04	9	67	2	17887960
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RGPD2 KDM5B CAMSAP3 RGPD1 CHD6 CAMSAP1	1.56e-04	418	67	6	34709266
Pubmed	An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity.	NEUROD1 GFAP	1.63e-04	10	67	2	32994168
Pubmed	The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.	NUP133 SEC31A	1.63e-04	10	67	2	15146057
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD2 RGPD1	1.63e-04	10	67	2	8857542
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD2 RGPD1	1.63e-04	10	67	2	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD2 RGPD1	1.63e-04	10	67	2	16332688
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD2 RGPD1	1.63e-04	10	67	2	21859863
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	BLM RGPD2 ANK2 MTERF1 RGPD1	1.80e-04	271	67	5	32433965
Pubmed	Noggin and chordin have distinct activities in promoting lineage commitment of mouse embryonic stem (ES) cells.	NEUROD1 NEUROD2	1.99e-04	11	67	2	11969257
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD2 RGPD1	1.99e-04	11	67	2	35771867
Pubmed	Peroxidasin is essential for eye development in the mouse.	PXDN GFAP	1.99e-04	11	67	2	24895407
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD2 RGPD1	1.99e-04	11	67	2	17069463
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD2 RGPD1	1.99e-04	11	67	2	34110283
Pubmed	Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system.	NEUROD1 GFAP	1.99e-04	11	67	2	11032813
Pubmed	CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity.	CAMSAP3 CAMSAP1	2.38e-04	12	67	2	32839317
Pubmed	Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning.	LAMC3 WNT4	2.38e-04	12	67	2	26794322
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NOLC1 KDM5B TBC1D10B CARMIL2 SYNE2 CAMSAP3 SRGAP2 CAMSAP1	2.45e-04	861	67	8	36931259
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KDM5B WDR5 CHD6 INO80	2.46e-04	157	67	4	30186101
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KDM5B WDR5	2.81e-04	13	67	2	21502505
Pubmed	A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis.	NEUROD1 GFAP	2.81e-04	13	67	2	22588081
Pubmed	The γ3 chain of laminin is widely but differentially expressed in murine basement membranes: expression and functional studies.	LAMC3 GFAP	2.81e-04	13	67	2	22222602
Pubmed	Lifelong persistence of nuclear RNAs in the mouse brain.	NEUROD1 GFAP	2.81e-04	13	67	2	38574132
Cytoband	2p11.2	RGPD2 MAT2A RGPD1	1.16e-04	64	67	3	2p11.2
Cytoband	5q31	PCDHGA10 PCDHGA5 PCDHGA2	6.53e-04	115	67	3	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHGA10 PCDHGA5 PCDHGA2 DELE1	9.67e-04	298	67	4	chr5q31
GeneFamily	Clustered protocadherins	PCDHGA10 PCDHGA5 PCDHGA2	6.53e-04	64	48	3	20
GeneFamily	Abhydrolase domain containing	ABHD17B ABHD17C	1.54e-03	22	48	2	4
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD2 SH3TC2 RGPD1	3.52e-03	115	48	3	769
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cbln4_Fezf2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TYRO3 NEUROD1 NEUROD2 TMEM121B WNT4	4.32e-06	160	67	5	d8241404d775f9a709abdf17988f36293fcf4c58
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TYRO3 NEUROD1 NEUROD2 TMEM121B WNT4	5.32e-06	167	67	5	f1ce6e64ebede1f3ef36fe982f46919fd1f814dd
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TYRO3 NEUROD1 NEUROD2 TMEM121B WNT4	7.87e-06	181	67	5	58f76bb9ea1518c2b629a0256a3f6595a9278152
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEUROD1 ANK2 SEC31A WNT4 NEB	1.07e-05	193	67	5	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEUROD1 ANK2 SEC31A WNT4 NEB	1.07e-05	193	67	5	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEUROD1 ANK2 SEC31A WNT4 NEB	1.10e-05	194	67	5	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TLR10 TBXAS1 FGD2 TMEM132E DENND1C	1.16e-05	196	67	5	b71d711be5609115b00a57700885aca608920896
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	BLM ANK2 ATP6V0A4 NEB XKR4	1.19e-05	197	67	5	ff4df77117165b6b25315e29b0722cc136eba607
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tfh\|GI_small-bowel / Manually curated celltypes from each tissue	TLR10 PCDHGA10 RGPD1 WNT4	4.99e-05	134	67	4	bf94ce5edde8912a27010e229c313d8102d6de62
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-T-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TLR10 TBXAS1 CARMIL2 FGD2	5.28e-05	136	67	4	186be8e1595608004b8216892cb9c7a7f31fbb4d
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tnc\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEUROD1 WNT4 GCNT2 NEB	8.56e-05	154	67	4	0066b2b8cfc74603e97f271ef5efc7ec512110dc
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEUROD1 NEUROD2 TMEM121B WNT4	9.22e-05	157	67	4	5aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCell	356C-Fibroblasts-Fibroblast-D-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SH3TC2 FGD2 DENND1C GCNT2	9.68e-05	159	67	4	299e2162a82e31196d7f3a110c2db622349edfff
ToppCell	356C-Fibroblasts-Fibroblast-D\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SH3TC2 FGD2 DENND1C GCNT2	9.68e-05	159	67	4	0a3a363b30a8c741e1a3e2525725108d03c21776
ToppCell	10x5'-bone_marrow-Lymphocytic_B-ABC_aged-B_memory\|bone_marrow / Manually curated celltypes from each tissue	TLR10 ANK2 FGD2 CHAD	1.09e-04	164	67	4	746833f74095c0f25ce76baf1069f1848c231933
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MTERF1 MAT1A CHAD EVPL	1.17e-04	167	67	4	a90f905ef38437752e2b0b71bd0322a184de1861
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEUROD2 PXDN ACOT2 WNT4	1.20e-04	168	67	4	3fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCell	Int-URO-Lymphocyte-B-B_intermediate\|Int-URO / Disease, Lineage and Cell Type	TLR10 ANK2 WNT4 NEB	1.20e-04	168	67	4	5b3fb1fc8fea810c6d4e6feb42c24fb57e8066de
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TYRO3 NEUROD1 RGPD1 EVPL	1.28e-04	171	67	4	dd37e1693a5cfc42e40992d504f92048a8038b52
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLM LAMC3 SRGAP2 ABHD17C	1.37e-04	174	67	4	72df66319f6efbd88ecf439013d97409fbf3cb52
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLM LAMC3 SRGAP2 ABHD17C	1.37e-04	174	67	4	c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TYRO3 CARMIL2 PKP3 NEB	1.40e-04	175	67	4	3bdccb4037053795d62ab5b6fcc09cdd406f9b50
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-regulatory_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TYRO3 CARMIL2 PKP3 NEB	1.40e-04	175	67	4	770546ddaa49ee482c4c7577ab76efbc6c304a29
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-regulatory_T_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RGPD2 CCM2 GK SYNE2	1.43e-04	176	67	4	856a8c4211ea33d926b18d8959a03909562aa563
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TYRO3 SRGAP2 SERINC5 XKR4	1.46e-04	177	67	4	4d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLM TBXAS1 GK EVPL	1.46e-04	177	67	4	1d5a071157c755f3a27a5c3143015da04ee0b0dc
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-8\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TLR10 ABHD17B FGD2 NEB	1.46e-04	177	67	4	066e7500e7bdde88a7914f50a4661d8adf6db925
ToppCell	3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NEUROD1 CARMIL2 ANK2 CHAD	1.53e-04	179	67	4	878b15ea62e3405682a538f79f58d74b9cd3f398
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CHAD TEX11 GFAP	1.54e-04	69	67	3	2fd6df70cdc7477e4a3ebdf4537279a727ab1214
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CHAD TEX11 GFAP	1.54e-04	69	67	3	8e14f411cbaea9cb9bcb9351b2421e71d5828ccc
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CHAD TEX11 GFAP	1.54e-04	69	67	3	bc3170409d107c39534581d2f0b8d75f93519113
ToppCell	COVID-19-kidney-Podocyte\|kidney / Disease (COVID-19 only), tissue and cell type	TYRO3 SRGAP2 SERINC5 XKR4	1.66e-04	183	67	4	fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TYRO3 SRGAP2 SERINC5 XKR4	1.66e-04	183	67	4	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TYRO3 SRGAP2 SERINC5 XKR4	1.66e-04	183	67	4	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TYRO3 SRGAP2 SERINC5 XKR4	1.66e-04	183	67	4	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK2 SYNE2 ATP6V0A4 XKR4	1.70e-04	184	67	4	a60802e11dcc5f932811260b08a95a32f60f6b19
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK2 SYNE2 ATP6V0A4 XKR4	1.70e-04	184	67	4	39c230d32e4259bc784e0edfd9e2884c96898564
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK2 SYNE2 ATP6V0A4 XKR4	1.70e-04	184	67	4	2a2fb691cc9414ef5b06c26239d2da03d6d7e5c2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TYRO3 SRGAP2 SERINC5 XKR4	1.70e-04	184	67	4	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TYRO3 SRGAP2 SERINC5 XKR4	1.73e-04	185	67	4	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TYRO3 SRGAP2 SERINC5 XKR4	1.73e-04	185	67	4	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NEUROD1 NEUROD2 PCDHGA10 ACOT2	1.73e-04	185	67	4	0382bfbc96c23403b18fe439d8070ea9a7d29fd2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TYRO3 SRGAP2 SERINC5 XKR4	1.73e-04	185	67	4	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TYRO3 NEUROD2 TMEM121B WNT4	1.77e-04	186	67	4	56c139e679d640ea901ead657a8e8887e0fca098
ToppCell	droplet-Tongue-nan-24m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKP3 SYNE2 ATP6V0A4 EVPL	1.77e-04	186	67	4	2913b5fd0617d024d600ba7015ec7b1961dade83
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TLR10 TBXAS1 FGD2 SRGAP2	1.81e-04	187	67	4	17a37fc3a1d62fef3137e5ff26a84c0b8c80e124
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TLR10 TBXAS1 FGD2 SRGAP2	1.81e-04	187	67	4	1b0eb29394040555516677b9de75c15e769c4c53
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TLR10 TBXAS1 FGD2 SRGAP2	1.81e-04	187	67	4	11c773cf3dc1e725b7e4d8edd676c8a94a231d2a
ToppCell	normal-na-Lymphocytic_B-B_atypical-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	TLR10 ANK2 FGD2 NEB	1.84e-04	188	67	4	e5ab89030783461e9367ab87c353fb5c31911020
ToppCell	normal-na-Lymphocytic_B-B_atypical\|normal / PBMC cell types (v2) per disease, treatment status, and sex	TLR10 ANK2 FGD2 NEB	1.84e-04	188	67	4	13653481d64c7a1ad833d738a3ee0bb9def7cec7
ToppCell	21-Trachea-Epithelial-Neuroendocrine\|Trachea / Age, Tissue, Lineage and Cell class	NEUROD1 ANK2 TMEM121B NEB	1.84e-04	188	67	4	e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pro_B_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PXDN ABHD17B GNPTAB SERINC5	1.96e-04	191	67	4	40813c397f533c2f4a6359a77757f736b6d9e07d
ToppCell	facs-Skin\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKP3 SYNE2 CAMSAP3 WNT4	1.96e-04	191	67	4	ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PXDN LAMC3 WNT4 GCNT2	1.96e-04	191	67	4	06760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-D\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RGPD2 FGD2 MAT2A RGPD1	2.00e-04	192	67	4	181d22fbb98a619a7f302c0f6623cee94c49a253
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NEUROD1 NEUROD2 PCDHGA10 SYNE2	2.00e-04	192	67	4	3b0a52e4e77ae4539a034dcb419773b8e2aa5d51
ToppCell	21-Trachea-Epithelial-Epithelial\|Trachea / Age, Tissue, Lineage and Cell class	ANK2 GAL3ST3 XKR4 GFAP	2.04e-04	193	67	4	9a8bb44a37f3202e3123a6680bd5545dc91a6d40
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE2 SERINC5 TEX11 SEC31B	2.04e-04	193	67	4	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYRO3 PKP3 SYNE2 EVPL	2.08e-04	194	67	4	a3adcdc8b87332e8beb9bcd70cf36424af10633d
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TBXAS1 FGD2 TMEM121B SRGAP2	2.08e-04	194	67	4	abce1e824ce2512741c313a5ec336d12f580b093
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NEUROD1 ANK2 WNT4 XKR4	2.08e-04	194	67	4	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TBXAS1 FGD2 TMEM121B SRGAP2	2.08e-04	194	67	4	6810586080cc893e3270b9c8bee2d95ed78e2893
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TBXAS1 GK FGD2 SRGAP2	2.12e-04	195	67	4	62dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCell	facs-Brain_Non-Myeloid-Cortex\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYRO3 ANK2 ABHD17B GABBR1	2.16e-04	196	67	4	256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCell	(5)_Fibroblast-J_(Lipofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	TYRO3 ANK2 WNT4 TEX11	2.16e-04	196	67	4	afa29399decd17fda7d63add5039ff778627ccc2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TBXAS1 GK FGD2 SRGAP2	2.20e-04	197	67	4	8af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE2 SERINC5 TEX11 SEC31B	2.20e-04	197	67	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Dendritic_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TLR10 TBXAS1 FGD2 SRGAP2	2.20e-04	197	67	4	e0fc098bfb5a8b7824ae339f3adda30f78360d0b
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Dendritic_cell\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TLR10 TBXAS1 FGD2 TMEM132E	2.20e-04	197	67	4	7e15ed71881105dee5c7ffc052063ecc8ac0b36e
ToppCell	proximal-Epithelial-Neuroendocrine\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GLYATL3 NEUROD1 TMEM121B NEB	2.25e-04	198	67	4	5dea6078488d584513c0bdbf5bba54877310b54a
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	KDM5B NEUROD1 NEUROD2 SYNE2	2.25e-04	198	67	4	6d12ecaa9532c134d9c4562534dcb59a6420b4d3
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	KDM5B NEUROD1 NEUROD2 SYNE2	2.25e-04	198	67	4	7943e4f67c3d6efb5c8b00aa0ff3cfe7be10c48d
ToppCell	proximal-Epithelial-Neuroendocrine-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GLYATL3 NEUROD1 TMEM121B NEB	2.25e-04	198	67	4	00ccf3020667cf2130bc354b441b65c0b1b0e862
ToppCell	proximal-3-Epithelial-Neuroendocrine\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GLYATL3 NEUROD1 TMEM121B NEB	2.25e-04	198	67	4	a6bc043faf68468d46bac441cf7447c236c7bae4
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TLR10 TBXAS1 FGD2 TMEM132E	2.25e-04	198	67	4	fa5c15a656d4132950092919600e270f1fd79abf
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_2\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TBXAS1 GK FGD2 TMEM132E	2.25e-04	198	67	4	115f564af8d7b89ac0331d3831faaef694043fd4
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-PNs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	KDM5B NEUROD1 SND1 SEC31A	2.25e-04	198	67	4	6408653e956fedb284fa5e69ba8f4d620731f556
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TLR10 TBXAS1 FGD2 SRGAP2	2.29e-04	199	67	4	744b63fba33b176ab7dde11646ccb313665505f7
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TBXAS1 GK FGD2 TMEM132E	2.29e-04	199	67	4	d330e28075096a09da3c27db8b52e364967c1e34
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Transitional_AT2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	PXDN ANK2 ATP6V0A4 XKR4	2.29e-04	199	67	4	cd581d7330b471431ef427f8a4f5be553f70e068
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYRO3 ANK2 ABHD17B SERINC5	2.33e-04	200	67	4	0e85c90719d9ec51a566e230c9dd2909d8df1f52
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TMEM132E GNPTAB SYNE2 DENND1C	2.33e-04	200	67	4	eda7a1d822e8663510662bc0ca34eaccc88d71ca
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TLR10 TBXAS1 GK FGD2	2.33e-04	200	67	4	27f498bcd706d0751091662996795b5270e46f14
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CHAD TEX11 GFAP	2.48e-04	81	67	3	2c58dbad21e0fbe46b005bcaf45139d098a2057a
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CHAD TEX11 GFAP	2.48e-04	81	67	3	a0b45dc22077805eba94689568b874415f515d61
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CHAD TEX11 GFAP	2.48e-04	81	67	3	571884bcf4282053c6170609ae0c794a6df05cd9
ToppCell	Frontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Myoc)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHAD TEX11 GFAP	2.86e-04	85	67	3	786258a945fd9c67d473fc66d4b6c147cb9dfd86
ToppCell	Frontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Myoc)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHAD TEX11 GFAP	2.86e-04	85	67	3	7bb9cd33f2131ac0d3aa6b13b0ffa2ee8cbff8c6
ToppCell	Frontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Myoc)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHAD TEX11 GFAP	2.86e-04	85	67	3	d004ba0fbef8b4d07b5b26e6b935c793d52431e0
Drug	TCNQ	TYRO3 MAT1A HAO1	5.02e-06	12	66	3	CID000073697
Drug	2-amino-4-methylthio-3-butenoic acid	MAT1A MAT2A	8.28e-06	2	66	2	ctd:C083253
Drug	rotenone; Down 200; 1uM; PC3; HT_HG-U133A	TBXAS1 ABHD17B PCDHGA10 PKP3 NEB CAMSAP1	2.29e-05	197	66	6	5948_DN
Drug	L-2-amino-4-methylthio-cis-but-3-enoic acid	MAT1A MAT2A	2.48e-05	3	66	2	CID006439623
Drug	benzylphosphate	MAT1A MAT2A	2.48e-05	3	66	2	CID000074359
Disease	lipid metabolism disorder (implicated_via_orthology)	MAT1A MAT2A FADS2B	4.77e-06	15	66	3	DOID:3146 (implicated_via_orthology)
Disease	mental development measurement	PCDHGA10 PCDHGA5 PCDHGA2	2.37e-05	25	66	3	EFO_0008230
Disease	endometriosis	LAMC3 WNT4 TEX11 XKR4 ABHD17C	2.55e-04	252	66	5	EFO_0001065
Disease	memory performance	GLT8D1 PXDN MTERF1 SYNE2 WDR5 NEB	3.08e-04	409	66	6	EFO_0004874
Disease	alcohol and nicotine codependence	RGPD2 RGPD1	3.78e-04	13	66	2	EFO_0004776
Disease	eosinophil count	TBXAS1 SH3TC2 CCM2 RAB4B CARMIL2 PXDN MTERF1 TMEM121B NUP133 SEC31A GABBR1	4.30e-04	1488	66	11	EFO_0004842
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGA10 PCDHGA5 PCDHGA2	5.48e-04	71	66	3	EFO_0007878, EFO_0007979
Disease	central nervous system disease (implicated_via_orthology)	SEC31A SEC31B	5.79e-04	16	66	2	DOID:331 (implicated_via_orthology)
Disease	Sarcosine measurement	PCDHGA5 PCDHGA2	1.21e-03	23	66	2	EFO_0021668
Disease	Brain Diseases	MAT1A LAMC3	1.43e-03	25	66	2	C0006111
Disease	Encephalopathies	MAT1A LAMC3	1.67e-03	27	66	2	C0085584

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDAYRARASFSWKEL	ACOX3	21	O15254
LALSVAALSYNLWFR	CARMIL2	206	Q6F5E8
SRLYQWSLKSSAQFL	ACOT2	31	P49753
AVLSLSAYNVKLAWR	CCM2	111	Q9BSQ5
KDLRWLYLSENALSS	CHAD	171	O15335
SGALRSYQLWADNLK	DENND1C	416	Q8IV53
RYDAARAKIAANLQW	CAMSAP1	31	Q5T5Y3
QYDFSRAKAAASLAW	CAMSAP3	26	Q9P1Y5
NASSLLDIYSFWLKS	NOLC1	46	Q14978
RDSGQNAWLSYHLLK	PCDHGA2	596	Q9Y5H1
YNSLAAWLTDARTLA	RAB4B	96	P61018
KDSGQNAWLSYRLLK	PCDHGA5	596	Q9Y5G8
ARWLALFLSLKASYR	INO80	911	Q9ULG1
LAKEAERNSYRLSWG	ANK2	936	Q01484
LSLGQYLWAASLAEK	NUP133	851	Q8WUM0
RSTTWKLNNLLLNDY	nan	246	O00370
STYFSAVKLRWLLDN	GK3P	146	Q14409
YLLWDLSAISQSKQD	GNPTAB	301	Q3T906
YDAIWALALALNKTS	GABBR1	471	Q9UBS5
QLALDLLSWSKDTYS	GCNT2	281	Q8N0V5
DRSAAYAARWVAKSL	MAT2A	291	P31153
DSGQNAWLSYRLLKA	PCDHGA10	601	Q9Y5H3
YRDLLKAASWRGQSL	EVPL	211	Q92817
TLADNIAAFSRWKLY	HAO1	36	Q9UJM8
DRSAAYAARWVAKSL	MAT1A	291	Q00266
SWLNSDSLKSIRYKI	GLT8D1	111	Q68CQ7
NALKLRAESYNEWAL	KDM5B	746	Q9UGL1
WYRSKFADLTDAAAR	GFAP	256	P14136
VRALKKSAALWADAY	FADS2B	466	A8MWK0
YLSVANADLLNRTWS	GLYATL3	156	Q5SZD4
AWDLDDVLYAKLNAR	GAL3ST3	256	Q96A11
ARLSSDWAHLYLQRK	ADAM30	286	Q9UKF2
SRLWLAALKDYALLT	HEATR5B	1481	Q9P2D3
FNKSDASLLGSLWRY	BLM	416	P54132
KSLLDWLRQQADYSL	CHD6	2356	Q8TD26
STYFSAVKLRWLLDN	GK	146	P32189
KNLYADIDAAWQALR	ABHD17C	181	Q6PCB6
RYLNSLKNKLSSEAW	FGD2	71	Q7Z6J4
RAVKYLWLAANNGDS	DELE1	371	Q14154
KSDWRATNTDLLLAY	RGPD1	216	P0DJD0
LDLSNNRLKSVTWYL	TLR10	101	Q9BXR5
LWLYELNAAAAAAAS	TMEM121B	441	Q9BXQ6
LLSYNRDSDQLTKWL	SYNE2	4946	Q8WXH0
LKQEALLSLWLSYSD	TMEM132E	721	Q6IEE7
DWRATNTDLLLAYAN	RGPD2	226	P0DJD1
AQESAKSARLNLWRY	SND1	881	Q7KZF4
CLAWAYLLASQAKKA	SH3TC2	801	Q8TF17
KNWREALALLLTYSG	SEC31B	641	Q9NQW1
NLYADIEAAWLALRT	ABHD17B	141	Q5VST6
AASSLLANLWQYNKL	PKP3	766	Q9Y446
SVALLALLKWYSTSA	TBXAS1	21	P24557
ALLKWYSTSAFSRLE	TBXAS1	26	P24557
DDKVYILLWLLNSDS	UBE3D	276	Q7Z6J8
AGTASNKLWYASLAL	SERINC5	186	Q86VE9
KGASLLLYQRASDDW	SRGAP2	751	O75044
LWLADLLKTYAESGN	PXDN	201	Q92626
ASLVSLAWALASYQK	XKR4	341	Q5GH76
LAWALASYQKALRDS	XKR4	346	Q5GH76
LNITLLSWSKKRYEA	MTERF1	376	Q99551
KVLRLLATNYLDWDD	TEX11	266	Q8IYF3
RAKAWQYLSNSKELL	TBC1D10B	366	Q4KMP7
SNTASYLRLWALSLA	ATP6V0A4	736	Q9HBG4
AVFSAAASNWLYLAK	WNT4	16	P56705
LKNWREALAAVLTYA	SEC31A	646	O94979
RLWAKNSEGSLDRLY	USP11	241	P51784
AATLDNTLKLWDYSK	WDR5	231	P61964
VKWLALESLADNLYT	TYRO3	696	Q06418
TAWRALLASNTSYAL	LAMC3	1176	Q9Y6N6
LQSDAIYKSDLEWLR	NEB	3621	P20929
ETLRLAKNYIWALSE	NEUROD1	141	Q13562
ETLRLAKNYIWALSE	NEUROD2	161	Q15784