Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 ATP6V0A4 SLC5A9 SLC5A3	3.81e-07	301	81	10	GO:0022853
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC6A9 SLC9A8 SLC9A1 SLC9A3 SLC8B1 SLC5A9 CACNA1G SLC5A3	4.64e-07	171	81	8	GO:0015081
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 ABCA4 SLC8B1 ATP6V0A4 SLC5A9 SLC15A5 SLC5A3	4.78e-07	477	81	12	GO:0022804
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 ABCA4 SLC8B1 SLC38A9 SLC2A7 ATP6V0A4 SLC5A9 SLC15A5 CACNA1G TMC4 UNC80 SLC2A5 SLC5A3	8.87e-07	1180	81	18	GO:0022857
GeneOntologyMolecularFunction	hexose transmembrane transporter activity	SLC2A7 SLC5A9 SLC2A5 SLC5A3	2.98e-06	25	81	4	GO:0015149
GeneOntologyMolecularFunction	D-glucose transmembrane transporter activity	SLC2A7 SLC5A9 SLC2A5 SLC5A3	2.98e-06	25	81	4	GO:0055056
GeneOntologyMolecularFunction	transporter activity	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 ABCA4 SLC8B1 SLC38A9 SLC2A7 ATP6V0A4 SLC5A9 SLC15A5 CACNA1G TMC4 UNC80 SLC2A5 SLC5A3	3.13e-06	1289	81	18	GO:0005215
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 SLC8B1 SLC5A9 SLC15A5 SLC5A3	3.14e-06	296	81	9	GO:0015291
GeneOntologyMolecularFunction	monosaccharide transmembrane transporter activity	SLC2A7 SLC5A9 SLC2A5 SLC5A3	4.11e-06	27	81	4	GO:0015145
GeneOntologyMolecularFunction	sugar transmembrane transporter activity	SLC2A7 SLC5A9 SLC2A5 SLC5A3	5.52e-06	29	81	4	GO:0051119
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 ATP6V0A4 SLC5A9 CACNA1G TMC4 UNC80 SLC5A3	1.71e-05	793	81	13	GO:0015075
GeneOntologyMolecularFunction	potassium:proton antiporter activity	SLC9A8 SLC9A1 SLC9A3	2.27e-05	14	81	3	GO:0015386
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	SLC2A7 SLC5A9 SLC2A5 SLC5A3	2.50e-05	42	81	4	GO:0015144
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC9A8 SLC9A1 SLC9A3 SLC8B1	2.75e-05	43	81	4	GO:0140828
GeneOntologyMolecularFunction	sodium:proton antiporter activity	SLC9A8 SLC9A1 SLC9A3	3.47e-05	16	81	3	GO:0015385
GeneOntologyMolecularFunction	solute:potassium antiporter activity	SLC9A8 SLC9A1 SLC9A3	5.95e-05	19	81	3	GO:0022821
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A9 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 ATP6V0A4 SLC5A9 CACNA1G UNC80 SLC5A3	7.40e-05	664	81	11	GO:0008324
GeneOntologyMolecularFunction	ferric-chelate reductase (NADPH) activity	STEAP3 STEAP2	1.61e-04	5	81	2	GO:0052851
GeneOntologyMolecularFunction	ferric-chelate reductase activity	STEAP3 STEAP2	1.61e-04	5	81	2	GO:0000293
GeneOntologyMolecularFunction	cupric reductase (NADH) activity	STEAP3 STEAP2	1.61e-04	5	81	2	GO:0008823
GeneOntologyMolecularFunction	metal cation:proton antiporter activity	SLC9A8 SLC9A1 SLC9A3	1.75e-04	27	81	3	GO:0051139
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A9 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 ATP6V0A4 SLC5A9 CACNA1G SLC5A3	2.19e-04	627	81	10	GO:0022890
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 ATP6V0A4 SLC5A9 CACNA1G SLC5A3	2.36e-04	758	81	11	GO:0015318
GeneOntologyMolecularFunction	antiporter activity	SLC26A8 SLC9A8 SLC9A1 SLC9A3 SLC8B1	2.46e-04	138	81	5	GO:0015297
GeneOntologyMolecularFunction	D-glucose:sodium symporter activity	SLC5A9 SLC5A3	3.37e-04	7	81	2	GO:0005412
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	STEAP3 STEAP2	3.37e-04	7	81	2	GO:0016723
GeneOntologyMolecularFunction	fructose transmembrane transporter activity	SLC2A7 SLC2A5	5.74e-04	9	81	2	GO:0005353
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A9 SLC9A8 SLC9A1 SLC9A3 SLC8B1 SLC5A9 CACNA1G SLC5A3	5.92e-04	465	81	8	GO:0046873
GeneOntologyMolecularFunction	proton transmembrane transporter activity	SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 ATP6V0A4	1.01e-03	188	81	5	GO:0015078
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DENND5B ARHGAP5 ARHGAP40 SLC38A9 EIF2B2 ARHGAP28 DEPDC5 DENND5A	1.04e-03	507	81	8	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DENND5B ARHGAP5 ARHGAP40 SLC38A9 EIF2B2 ARHGAP28 DEPDC5 DENND5A	1.04e-03	507	81	8	GO:0030695
GeneOntologyMolecularFunction	carbohydrate:monoatomic cation symporter activity	SLC5A9 SLC5A3	2.12e-03	17	81	2	GO:0005402
GeneOntologyMolecularFunction	plus-end-directed microtubule motor activity	KIF1A KIF1B	2.12e-03	17	81	2	GO:0008574
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions	STEAP3 STEAP2	2.38e-03	18	81	2	GO:0016722
GeneOntologyMolecularFunction	symporter activity	SLC6A9 SLC5A9 SLC15A5 SLC5A3	3.25e-03	150	81	4	GO:0015293
GeneOntologyMolecularFunction	ATPase-coupled ion transmembrane transporter activity	ATP6V0A1 ATP6V0A4	4.23e-03	24	81	2	GO:0042625
GeneOntologyMolecularFunction	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	ATP6V0A1 ATP6V0A4	4.23e-03	24	81	2	GO:0044769
GeneOntologyMolecularFunction	proton-transporting ATPase activity, rotational mechanism	ATP6V0A1 ATP6V0A4	4.23e-03	24	81	2	GO:0046961
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC6A9 SLC5A9 SLC5A3	4.37e-03	81	81	3	GO:0015370
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIK3C2A PI4KA	4.96e-03	26	81	2	GO:0052742
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC6A9 SLC9A8 SLC9A1 SLC9A3 SLC8B1 SLC5A9 CACNA1G SLC5A3	1.45e-06	208	80	8	GO:0035725
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 PIK3C2A ATP6V0A4 STEAP3 SLC5A9 CACNA1G TMC4 STEAP2 UNC80 SLC5A3	4.88e-06	1115	80	16	GO:0034220
GeneOntologyBiologicalProcess	sodium ion transport	SLC6A9 SLC9A8 SLC9A1 SLC9A3 SLC8B1 SLC5A9 CACNA1G SLC5A3	1.14e-05	275	80	8	GO:0006814
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC6A9 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 PIK3C2A ATP6V0A4 STEAP3 SLC5A9 CACNA1G STEAP2 UNC80 SLC5A3	1.41e-05	942	80	14	GO:0098655
GeneOntologyBiologicalProcess	import across plasma membrane	SLC6A9 SLC9A1 SLC9A3 CACNA1G STEAP2 SLC2A5 SLC5A3	3.11e-05	230	80	7	GO:0098739
GeneOntologyBiologicalProcess	regulation of intracellular pH	SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 ATP6V0A4	3.24e-05	94	80	5	GO:0051453
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 PIK3C2A ATP6V0A4 STEAP3 SLC5A9 CACNA1G STEAP2 SLC5A3	3.30e-05	1017	80	14	GO:0098660
GeneOntologyBiologicalProcess	regulation of cellular pH	SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 ATP6V0A4	4.58e-05	101	80	5	GO:0030641
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC6A9 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 PIK3C2A ATP6V0A4 STEAP3 SLC5A9 CACNA1G STEAP2 SLC5A3	5.12e-05	922	80	13	GO:0098662
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 PIK3C2A ATP6V0A4 STEAP3 SLC5A9 CACNA1G TMC4 STEAP2 UNC80 SLC5A3	6.39e-05	1374	80	16	GO:0006811
GeneOntologyBiologicalProcess	regulation of pH	SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 ATP6V0A4	1.04e-04	120	80	5	GO:0006885
GeneOntologyBiologicalProcess	monoatomic cation transport	SLC6A9 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 SLC8B1 PIK3C2A ATP6V0A4 STEAP3 SLC5A9 CACNA1G STEAP2 UNC80 SLC5A3	1.32e-04	1157	80	14	GO:0006812
GeneOntologyBiologicalProcess	iron ion import across cell outer membrane	STEAP3 STEAP2	1.47e-04	5	80	2	GO:0098706
GeneOntologyBiologicalProcess	retrograde neuronal dense core vesicle transport	KIF1A KIF1B	2.21e-04	6	80	2	GO:1990049
GeneOntologyBiologicalProcess	anterograde neuronal dense core vesicle transport	KIF1A KIF1B	4.10e-04	8	80	2	GO:1990048
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	ABHD17A SLC6A9 TMEM67 SLC9A8 SLC9A3 ATP6V0A1 ABCA4 KIF1A SLC38A9 PI4KA KIF1B ATP6V0A4 DLL3 STEAP3 ITGA2B PTCH1 STEAP2 SLC2A5	2.41e-06	1307	82	18	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	ABHD17A SLC6A9 TMEM67 SLC9A8 SLC9A3 ATP6V0A1 ABCA4 KIF1A SLC38A9 PI4KA KIF1B ATP6V0A4 DLL3 STEAP3 ITGA2B PTCH1 STEAP2 SLC2A5	2.92e-06	1325	82	18	GO:0012506
GeneOntologyCellularComponent	apical part of cell	SLC6A9 FAT1 SLC9A8 SLC9A1 SLC9A3 SLC2A7 ATP6V0A4 PTCH1 SLC2A5 SLC5A3	1.05e-04	592	82	10	GO:0045177
GeneOntologyCellularComponent	apical plasma membrane	SLC6A9 FAT1 SLC9A8 SLC9A1 SLC9A3 SLC2A7 ATP6V0A4 SLC2A5 SLC5A3	1.22e-04	487	82	9	GO:0016324
GeneOntologyCellularComponent	endosome membrane	ABHD17A SLC9A8 SLC9A3 ATP6V0A1 SLC38A9 ATP6V0A4 DLL3 STEAP3 STEAP2	5.80e-04	602	82	9	GO:0010008
GeneOntologyCellularComponent	vacuolar proton-transporting V-type ATPase, V0 domain	ATP6V0A1 ATP6V0A4	6.70e-04	10	82	2	GO:0000220
GeneOntologyCellularComponent	cation-transporting ATPase complex	SLC9A1 ATP6V0A1 ATP6V0A4	9.41e-04	49	82	3	GO:0090533
GeneOntologyCellularComponent	proton-transporting V-type ATPase, V0 domain	ATP6V0A1 ATP6V0A4	9.78e-04	12	82	2	GO:0033179
GeneOntologyCellularComponent	semaphorin receptor complex	SEMA4D PLXNA1	1.15e-03	13	82	2	GO:0002116
GeneOntologyCellularComponent	ATPase dependent transmembrane transport complex	SLC9A1 ATP6V0A1 ATP6V0A4	1.32e-03	55	82	3	GO:0098533
Domain	NaH_exchanger	SLC9A8 SLC9A1 SLC9A3	5.78e-06	9	78	3	IPR004709
Domain	Cation/H_exchanger_CPA1	SLC9A8 SLC9A1 SLC9A3	1.13e-05	11	78	3	IPR018422
Domain	Fru_transpt_5	SLC2A7 SLC2A5	1.72e-05	2	78	2	IPR002442
Domain	Na_H_Exchanger	SLC9A8 SLC9A1 SLC9A3	2.47e-05	14	78	3	PF00999
Domain	Cation/H_exchanger	SLC9A8 SLC9A1 SLC9A3	2.47e-05	14	78	3	IPR006153
Domain	Kinesin-like_KIF1-typ	KIF1A KIF1B	1.03e-04	4	78	2	IPR022140
Domain	KIF1B	KIF1A KIF1B	1.03e-04	4	78	2	PF12423
Domain	V-type_ATPase_116kDa_su_euka	ATP6V0A1 ATP6V0A4	1.03e-04	4	78	2	IPR026028
Domain	V_ATPase_I	ATP6V0A1 ATP6V0A4	1.03e-04	4	78	2	PF01496
Domain	V-ATPase_116kDa_su	ATP6V0A1 ATP6V0A4	1.03e-04	4	78	2	IPR002490
Domain	Kinesin_assoc	KIF1A KIF1B	2.55e-04	6	78	2	PF16183
Domain	Kinesin_assoc	KIF1A KIF1B	2.55e-04	6	78	2	IPR032405
Domain	DUF3694	KIF1A KIF1B	2.55e-04	6	78	2	PF12473
Domain	Kinesin-like	KIF1A KIF1B	2.55e-04	6	78	2	IPR022164
Domain	ProC_N	STEAP3 STEAP2	3.57e-04	7	78	2	IPR028939
Domain	F420_oxidored	STEAP3 STEAP2	3.57e-04	7	78	2	PF03807
Domain	6hp_glycosidase	PGGHG SPATA20	4.74e-04	8	78	2	IPR012341
Domain	Na/solute_symporter_CS	SLC5A9 SLC5A3	4.74e-04	8	78	2	IPR018212
Domain	-	PGGHG SPATA20	4.74e-04	8	78	2	1.50.10.10
Domain	PI3Ka	PIK3C2A PI4KA	6.08e-04	9	78	2	PF00613
Domain	-	PIK3C2A PI4KA	6.08e-04	9	78	2	1.25.40.70
Domain	PI3Ka	PIK3C2A PI4KA	6.08e-04	9	78	2	SM00145
Domain	PIK_HELICAL	PIK3C2A PI4KA	7.58e-04	10	78	2	PS51545
Domain	PI_Kinase	PIK3C2A PI4KA	7.58e-04	10	78	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2A PI4KA	7.58e-04	10	78	2	IPR001263
Domain	NA_SOLUT_SYMP_1	SLC5A9 SLC5A3	9.24e-04	11	78	2	PS00456
Domain	NA_SOLUT_SYMP_2	SLC5A9 SLC5A3	1.11e-03	12	78	2	PS00457
Domain	SSF	SLC5A9 SLC5A3	1.11e-03	12	78	2	PF00474
Domain	Na/solute_symporter	SLC5A9 SLC5A3	1.11e-03	12	78	2	IPR001734
Domain	Ferric_reduct	STEAP3 STEAP2	1.11e-03	12	78	2	PF01794
Domain	NA_SOLUT_SYMP_3	SLC5A9 SLC5A3	1.11e-03	12	78	2	PS50283
Domain	Fe3_Rdtase_TM_dom	STEAP3 STEAP2	1.11e-03	12	78	2	IPR013130
Domain	Cadherin_CS	FAT1 PCDHGB7 PCDHGB6 CDHR4	1.12e-03	109	78	4	IPR020894
Domain	CADHERIN_1	FAT1 PCDHGB7 PCDHGB6 CDHR4	1.28e-03	113	78	4	PS00232
Domain	Cadherin	FAT1 PCDHGB7 PCDHGB6 CDHR4	1.28e-03	113	78	4	PF00028
Domain	6-hairpin_glycosidase-like	PGGHG SPATA20	1.30e-03	13	78	2	IPR008928
Domain	CADHERIN_2	FAT1 PCDHGB7 PCDHGB6 CDHR4	1.33e-03	114	78	4	PS50268
Domain	-	FAT1 PCDHGB7 PCDHGB6 CDHR4	1.33e-03	114	78	4	2.60.40.60
Domain	SMAD_FHA_domain	IRF9 KIF1A KIF1B	1.34e-03	52	78	3	IPR008984
Domain	CA	FAT1 PCDHGB7 PCDHGB6 CDHR4	1.37e-03	115	78	4	SM00112
Domain	Cadherin-like	FAT1 PCDHGB7 PCDHGB6 CDHR4	1.41e-03	116	78	4	IPR015919
Domain	Cadherin	FAT1 PCDHGB7 PCDHGB6 CDHR4	1.51e-03	118	78	4	IPR002126
Domain	uDENN	DENND5B DENND5A	1.52e-03	14	78	2	SM00800
Domain	Sugar/inositol_transpt	SLC2A7 SLC2A5	1.52e-03	14	78	2	IPR003663
Domain	uDENN	DENND5B DENND5A	1.75e-03	15	78	2	PF03456
Domain	PI3/4_kinase_CS	PIK3C2A PI4KA	1.75e-03	15	78	2	IPR018936
Domain	UDENN	DENND5B DENND5A	1.99e-03	16	78	2	PS50946
Domain	DDENN	DENND5B DENND5A	1.99e-03	16	78	2	PS50947
Domain	DENN	DENND5B DENND5A	1.99e-03	16	78	2	SM00799
Domain	-	PIK3C2A PI4KA	1.99e-03	16	78	2	1.10.1070.11
Domain	dDENN	DENND5B DENND5A	1.99e-03	16	78	2	SM00801
Domain	DENN	DENND5B DENND5A	1.99e-03	16	78	2	PF02141
Domain	dDENN_dom	DENND5B DENND5A	1.99e-03	16	78	2	IPR005112
Domain	uDENN_dom	DENND5B DENND5A	1.99e-03	16	78	2	IPR005113
Domain	dDENN	DENND5B DENND5A	1.99e-03	16	78	2	PF03455
Domain	DENN	DENND5B DENND5A	1.99e-03	16	78	2	PS50211
Domain	DENN_dom	DENND5B DENND5A	1.99e-03	16	78	2	IPR001194
Domain	PI3Kc	PIK3C2A PI4KA	1.99e-03	16	78	2	SM00146
Domain	SUGAR_TRANSPORT_2	SLC2A7 SLC2A5	2.25e-03	17	78	2	PS00217
Domain	RUN	DENND5B DENND5A	2.52e-03	18	78	2	SM00593
Domain	PI3/4_kinase_cat_dom	PIK3C2A PI4KA	2.52e-03	18	78	2	IPR000403
Domain	PI3_PI4_kinase	PIK3C2A PI4KA	2.52e-03	18	78	2	PF00454
Domain	PI3_4_KINASE_3	PIK3C2A PI4KA	2.52e-03	18	78	2	PS50290
Domain	PI3_4_KINASE_1	PIK3C2A PI4KA	2.52e-03	18	78	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C2A PI4KA	2.52e-03	18	78	2	PS00916
Domain	RUN	DENND5B DENND5A	2.81e-03	19	78	2	PS50826
Domain	RUN	DENND5B DENND5A	2.81e-03	19	78	2	PF02759
Domain	Run_dom	DENND5B DENND5A	2.81e-03	19	78	2	IPR004012
Domain	PLAT	DENND5B DENND5A	3.43e-03	21	78	2	PS50095
Domain	-	DENND5B DENND5A	3.43e-03	21	78	2	2.60.60.20
Domain	PLAT	DENND5B DENND5A	3.43e-03	21	78	2	PF01477
Domain	PLAT/LH2_dom	DENND5B DENND5A	3.43e-03	21	78	2	IPR001024
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC6A9 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 ABCA4 SLC8B1 PSME4 SLC2A7 ATP6V0A4 STEAP3 SLC5A9 UNC80 SLC5A3	1.11e-06	681	62	14	MM14985
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC6A9 SLC9A8 SLC9A1 SLC9A3 ATP6V0A1 ABCA4 SLC8B1 PSME4 SLC2A7 ATP6V0A4 STEAP3 SLC5A9 UNC80 SLC5A3	2.77e-06	736	62	14	M27287
Pathway	REACTOME_SODIUM_PROTON_EXCHANGERS	SLC9A8 SLC9A1 SLC9A3	6.68e-06	9	62	3	M27337
Pathway	REACTOME_SODIUM_PROTON_EXCHANGERS	SLC9A8 SLC9A1 SLC9A3	6.68e-06	9	62	3	MM15079
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC6A9 SLC9A8 SLC9A1 SLC9A3 SLC8B1 SLC2A7 SLC5A9 SLC5A3	9.04e-06	238	62	8	MM15076
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC6A9 SLC9A8 SLC9A1 SLC9A3 SLC8B1 SLC2A7 SLC5A9 SLC5A3	1.26e-05	249	62	8	M5988
Pathway	REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING	ATP6V0A1 ATP6V0A4 STEAP3	3.34e-04	31	62	3	MM15639
Pathway	REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING	ATP6V0A1 ATP6V0A4 STEAP3	3.34e-04	31	62	3	M991
Pathway	WP_NRF2_PATHWAY	SLC6A9 SLC2A7 SLC5A9 SLC2A5 SLC5A3	3.82e-04	141	62	5	M39454
Pubmed	The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors.	KIF1A KIF1B	5.49e-06	2	82	2	7539720
Pubmed	Renal NHE expression and activity in neonatal NHE3- and NHE8-null mice.	SLC9A8 SLC9A3	5.49e-06	2	82	2	25377912
Pubmed	Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice.	SLC9A8 SLC9A3	5.49e-06	2	82	2	23054255
Pubmed	Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef.	SLC9A8 SLC9A1 SLC9A3	1.00e-05	18	82	3	24874739
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DIP2A MGAT4B FAT1 SLC8B1 PSME4 PI4KA STEAP3 SPATA20 DEPDC5 DENND5A PTCH1 PLXNA1	1.07e-05	1105	82	12	35748872
Pubmed	BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.	KIF1A KIF1B	1.64e-05	3	82	2	27851960
Pubmed	The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation.	SLC9A1 SLC9A3	1.64e-05	3	82	2	14962844
Pubmed	NHE2X3 DKO mice exhibit gender-specific NHE8 compensation.	SLC9A8 SLC9A3	1.64e-05	3	82	2	21252044
Pubmed	Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells.	SLC9A1 SLC9A3	1.64e-05	3	82	2	12842825
Pubmed	Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer.	STEAP3 STEAP2	1.64e-05	3	82	2	12095985
Pubmed	STAMPing at the crossroads of normal physiology and disease states.	STEAP3 STEAP2	1.64e-05	3	82	2	26911931
Pubmed	Differential patterns of inhibition of the sugar transporters GLUT2, GLUT5 and GLUT7 by flavonoids.	SLC2A7 SLC2A5	1.64e-05	3	82	2	29548810
Pubmed	In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.	KIF1A KIF1B	1.64e-05	3	82	2	23404705
Pubmed	Interferon-gamma suppresses Na+ -H+ exchanger in cultured human endolymphatic sac epithelial cells.	SLC9A1 SLC9A3	1.64e-05	3	82	2	19479940
Pubmed	The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.	ATP6V0A1 ATP6V0A4	1.64e-05	3	82	2	24072707
Pubmed	NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice.	SLC9A1 SLC9A3	1.64e-05	3	82	2	16690903
Pubmed	The a-subunit of the V-type H+-ATPase interacts with phosphofructokinase-1 in humans.	ATP6V0A1 ATP6V0A4	1.64e-05	3	82	2	12649290
Pubmed	Defective fluid secretion and NaCl absorption in the parotid glands of Na+/H+ exchanger-deficient mice.	SLC9A1 SLC9A3	1.64e-05	3	82	2	11358967
Pubmed	Targeted disruption of the Nhe1 gene prevents muscarinic agonist-induced up-regulation of Na(+)/H(+) exchange in mouse parotid acinar cells.	SLC9A1 SLC9A3	1.64e-05	3	82	2	10506152
Pubmed	The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function.	KIF1A KIF1B	3.28e-05	4	82	2	27263974
Pubmed	NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells.	SLC9A1 SLC9A3	3.28e-05	4	82	2	10666043
Pubmed	V1 and V0 domains of the human H+-ATPase are linked by an interaction between the G and a subunits.	ATP6V0A1 ATP6V0A4	3.28e-05	4	82	2	17360703
Pubmed	Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters.	SLC2A7 SLC2A5	3.28e-05	4	82	2	28083649
Pubmed	Na(+)-dependent transporters mediate HCO(3)(-) salvage across the luminal membrane of the main pancreatic duct.	SLC9A1 SLC9A3	3.28e-05	4	82	2	10841524
Pubmed	Contributions of Na+/H+ exchanger isoforms to preimplantation development of the mouse.	SLC9A1 SLC9A3	3.28e-05	4	82	2	9590530
Pubmed	Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.	STEAP3 STEAP2	3.28e-05	4	82	2	34649092
Pubmed	Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron.	ATP6V0A1 ATP6V0A4	3.28e-05	4	82	2	17595521
Pubmed	KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.	KIF1A KIF1B	5.47e-05	5	82	2	18849981
Pubmed	The Steap proteins are metalloreductases.	STEAP3 STEAP2	5.47e-05	5	82	2	16609065
Pubmed	The a subunit isoforms of vacuolar-type proton ATPase exhibit differential distribution in mouse perigastrulation embryos.	ATP6V0A1 ATP6V0A4	5.47e-05	5	82	2	35948619
Pubmed	A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.	SLC9A1 SLC9A3	5.47e-05	5	82	2	8901634
Pubmed	Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.	STEAP3 STEAP2	5.47e-05	5	82	2	12429817
Pubmed	Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.	ATP6V0A1 ATP6V0A4	8.19e-05	6	82	2	21307348
Pubmed	Lessons from genetically engineered animal models VIII. Absorption and secretion of ions in the gastrointestinal tract.	SLC9A1 SLC9A3	8.19e-05	6	82	2	10666041
Pubmed	Optic nerve compression and retinal degeneration in Tcirg1 mutant mice lacking the vacuolar-type H-ATPase a3 subunit.	ATP6V0A1 ATP6V0A4	1.14e-04	7	82	2	20711468
Pubmed	Genetic susceptibility to febrile seizures: case-control association studies.	SLC9A1 SLC9A3	1.14e-04	7	82	2	19854014
Pubmed	Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.	SLC9A1 SLC9A3	1.14e-04	7	82	2	12576672
Pubmed	Identification of novel cadherins expressed in human melanoma cells.	FAT1 PCDHGB7	1.14e-04	7	82	2	9182820
Pubmed	Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus.	SOX14 PTCH1	1.14e-04	7	82	2	14568100
Pubmed	NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos.	SLC9A1 SLC9A3	1.14e-04	7	82	2	23677982
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	PSME4 COG1 BAZ1A PI4KA ARHGAP28 VARS1	1.17e-04	322	82	6	26514267
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	KIF1A KIF1B	1.52e-04	8	82	2	25818806
Pubmed	Familial pure proximal renal tubular acidosis--a clinical and genetic study.	SLC9A8 SLC9A3	1.96e-04	9	82	2	17881426
Pubmed	Fibronectin stimulates migration through lipid raft dependent NHE-1 activation in mouse embryonic stem cells: involvement of RhoA, Ca(2+)/CaM, and ERK.	SLC9A1 SLC9A3	1.96e-04	9	82	2	22683701
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ARHGAP5 SEMA4D DIP2A ATP6V0A1 PIAS3 STAG1 KIF1A COG1 KIF1B PRPF8 VARS1	2.13e-04	1285	82	11	35914814
Pubmed	PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.	PIK3C2A PTCH1	2.98e-04	11	82	2	24697898
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	DIP2A SLC9A1 ATP6V0A1 BAZ1A SLC38A9 CHTF18 TRAPPC10 SPATA20 USP19	3.31e-04	925	82	9	28986522
Pubmed	The LMO2 oncogene regulates DNA replication in hematopoietic cells.	ZNF106 BAZ1A DENND5A	3.55e-04	58	82	3	26764384
Pubmed	The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5.	TMEM67 PTCH1	3.57e-04	12	82	2	30931988
Pubmed	Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.	KIF1A KIF1B	3.57e-04	12	82	2	16301330
Pubmed	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.	SEMA4D PLXNA1	4.21e-04	13	82	2	10520995
Pubmed	Structure and Roles of V-type ATPases.	ATP6V0A1 ATP6V0A4	4.21e-04	13	82	2	32001091
Pubmed	Mouse chromosomal location of four Na/H exchanger isoform genes.	SLC9A1 SLC9A3	4.91e-04	14	82	2	8824815
Pubmed	A gene expression map of human chromosome 21 orthologues in the mouse.	DIP2A N6AMT1 TRAPPC10 SLC5A3	5.44e-04	158	82	4	12466855
Pubmed	Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.	DLL3 PTCH1	5.65e-04	15	82	2	32561646
Pubmed	The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.	TMEM67 PTCH1	5.65e-04	15	82	2	26035863
Pubmed	Sequence identification of 2,375 human brain genes.	KIF1A CENPI	5.65e-04	15	82	2	1538749
Pubmed	Human chromosome 21 gene expression atlas in the mouse.	DIP2A N6AMT1 TRAPPC10 SLC5A3	6.12e-04	163	82	4	12466854
Pubmed	Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets.	ITGA2B PTCH1	6.45e-04	16	82	2	26457609
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	SEMA4D TBC1D31 TMC4 CCDC168	6.85e-04	168	82	4	30631154
Pubmed	Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.	ATP6V0A1 ATP6V0A4	7.30e-04	17	82	2	33065002
Pubmed	The Presynaptic v-ATPase Reversibly Disassembles and Thereby Modulates Exocytosis but Is Not Part of the Fusion Machinery.	ATP6V0A1 ATP6V0A4	7.30e-04	17	82	2	28793259
Pubmed	Introduction: V-ATPases 1992-1998.	ATP6V0A1 ATP6V0A4	8.20e-04	18	82	2	10340843
Pubmed	Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.	DENND5B DENND5A	8.20e-04	18	82	2	32496646
Pubmed	Animal plasma membrane energization by proton-motive V-ATPases.	ATP6V0A1 ATP6V0A4	8.20e-04	18	82	2	10440860
Pubmed	The vacuolar H+-ATPase: a universal proton pump of eukaryotes.	ATP6V0A1 ATP6V0A4	8.20e-04	18	82	2	9210392
Pubmed	Vacuolar and plasma membrane proton-adenosinetriphosphatases.	ATP6V0A1 ATP6V0A4	8.20e-04	18	82	2	10221984
Pubmed	Structure and properties of the vacuolar (H+)-ATPases.	ATP6V0A1 ATP6V0A4	8.20e-04	18	82	2	10224039
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	SLC6A9 SEMA4D SLC9A1 STEAP3 PLXNA1 SLC5A3	8.40e-04	467	82	6	30194290
Pubmed	Structure, function and regulation of the vacuolar (H+)-ATPase.	ATP6V0A1 ATP6V0A4	9.15e-04	19	82	2	9442887
Pubmed	Ciliary Hedgehog signaling regulates cell survival to build the facial midline.	TMEM67 PTCH1	9.15e-04	19	82	2	34672258
Pubmed	Unravelling the complex genetics of cleft lip in the mouse model.	ITGA2B PTCH1	9.15e-04	19	82	2	11353389
Pubmed	Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis.	ATP6V0A1 ATP6V0A4	9.15e-04	19	82	2	16177003
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	CRACD IRF9 STAG1 NELFCD BAZ1A PI4KA PRPF8 VARS1	9.41e-04	857	82	8	25609649
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	ABCA4 PRPF8 ADGRA3	9.44e-04	81	82	3	20301590
Pubmed	Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.	SEMA4D ABCA4	1.01e-03	20	82	2	22863734
Pubmed	The vacuolar (H+)-ATPases--nature's most versatile proton pumps.	ATP6V0A1 ATP6V0A4	1.23e-03	22	82	2	11836511
Pubmed	TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus.	CACNA1G SOX14	1.23e-03	22	82	2	32675279
Pubmed	Proton translocation driven by ATP hydrolysis in V-ATPases.	ATP6V0A1 ATP6V0A4	1.23e-03	22	82	2	12788495
Pubmed	Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes.	ATP6V0A1 ATP6V0A4	1.23e-03	22	82	2	14580332
Pubmed	Neurotransmitter release: the dark side of the vacuolar-H+ATPase.	ATP6V0A1 ATP6V0A4	1.23e-03	22	82	2	14597263
Pubmed	Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation.	ATP6V0A1 ATP6V0A4	1.23e-03	22	82	2	17662945
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	PI4KA DLL3 PLXNA1	1.28e-03	90	82	3	15033168
Pubmed	Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.	SEMA4D SLC9A3	1.35e-03	23	82	2	31748650
Pubmed	Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†.	SLC9A1 SLC9A3	1.47e-03	24	82	2	37471646
Pubmed	A semaphorin code defines subpopulations of spinal motor neurons during mouse development.	SEMA4D PLXNA1	1.47e-03	24	82	2	15869472
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF1A KIF1B	1.59e-03	25	82	2	9275178
Pubmed	Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor.	ATP6V0A1 ATP6V0A4	1.59e-03	25	82	2	2874839
Pubmed	Holoprosencephaly Overview	TRAPPC10 PTCH1	1.59e-03	25	82	2	20301702
Pubmed	Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice.	SOX14 PTCH1	1.59e-03	25	82	2	19357274
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	SLC9A8 SLC9A3 SLC5A9 SLC2A5	1.62e-03	212	82	4	19521566
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	CRACD ZNF106 CACNA1G TMC4 USP19	1.70e-03	363	82	5	14691545
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ATP6V0A1 FADS1 KIF1A COG1 PI4KA EIF2B2 VARS1 USP19	1.71e-03	942	82	8	31073040
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	TMEM67 PSME4 TRAPPC10	1.73e-03	100	82	3	25807483
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ATP6V0A1 KIF1A BAZ1A PI4KA COASY PRPF8 VARS1 PLXNA1 USP19 ADGRA3	1.90e-03	1425	82	10	30948266
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	SEMA4D PLXNA1	1.99e-03	28	82	2	18617019
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SLC9A8 TOGARAM1 CACNA1G UNC80	2.01e-03	225	82	4	12168954
Pubmed	Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains.	SOX14 PTCH1	2.14e-03	29	82	2	30177510
Pubmed	JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.	PSME4 BAZ1A	2.14e-03	29	82	2	27649575
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	SLC6A9 FAT1 SLC9A1 PI4KA STEAP3 PLXNA1	2.29e-03	569	82	6	30639242
Cytoband	1p36.2	SLC2A7 KIF1B SLC2A5	1.55e-06	13	82	3	1p36.2
GeneFamily	Solute carriers	SLC6A9 SLC26A8 SLC9A8 SLC9A1 SLC9A3 SLC8B1 SLC38A9 SLC2A7 SLC5A9 SLC15A5 SLC2A5 SLC5A3	1.88e-09	395	55	12	752
GeneFamily	Proteases, serine\|STEAP family	STEAP3 STEAP2	9.03e-05	5	55	2	1324
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP5 ARHGAP40 ARHGAP28	4.72e-04	50	55	3	721
GeneFamily	Cadherin related	FAT1 CDHR4	1.20e-03	17	55	2	24
GeneFamily	V-type ATPases	ATP6V0A1 ATP6V0A4	2.21e-03	23	55	2	415
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND5B DENND5A	2.61e-03	25	55	2	504
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF1A KIF1B	8.63e-03	46	55	2	622
CoexpressionAtlas	Mesoderm Day 5-reprogram_NA_vs_Mesoderm Day 5-reprogram_OSKM-Confounder_removed-fold2.0_adjp0.05	SLC6A9 LDLRAD2 CENPI SLC5A9	4.52e-05	53	79	4	PCBC_ratio_MESO-5_from-ESC_vs_MESO-5_from-OSKM_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_NA_vs_Mesoderm Day 5-method_retro-Confounder_removed-fold2.0_adjp0.05	SLC6A9 LDLRAD2 CENPI SLC5A9	4.52e-05	53	79	4	PCBC_ratio_MESO-5_from-ESC_vs_MESO-5_from-retro_cfr-2X-p05
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 ATP6V0A4 BRINP2 XRRA1 CACNA1G	1.80e-05	175	82	5	59249c9e83952d7277010e7be3c779e26399eb5d
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF1A CENPI DLL3 PLXNA1 UNC80	1.80e-05	175	82	5	8362a46f5804333baa84cd56d450bc147f372a7e
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF1A CENPI DLL3 PLXNA1 UNC80	1.80e-05	175	82	5	8b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 ATP6V0A4 BRINP2 XRRA1 CACNA1G	1.80e-05	175	82	5	b35cc1357495f2a03a6500f807c6e6f8c877734d
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_Erythro-Mega\|lymph-node_spleen / Manually curated celltypes from each tissue	SLC6A9 STEAP3 ITGA2B ADGRA3 SLC5A3	2.01e-05	179	82	5	957c08ad4b46eb4cc1717c45056fc3db50015fdc
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAT1 ARHGAP28 PTCH1 UNC80 ADGRA3	2.48e-05	187	82	5	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	FAT1 ARHGAP28 PTCH1 UNC80 ADGRA3	2.60e-05	189	82	5	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CHTF18 SLC5A9 DMRTA1 PTCH1 ADGRA3	2.81e-05	192	82	5	d6f656be2698bd215717d35f4e7ab727c08c61e0
ToppCell	facs-Brain_Non-Myeloid-Cortex\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4D DIP2A FADS1 KIF1A KIF1B	3.10e-05	196	82	5	256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PCDHGB7 KIF1A PCDHGB6 ATP6V0A4 UNC80	3.18e-05	197	82	5	ff4df77117165b6b25315e29b0722cc136eba607
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	TMEM67 DIP2A MGAT4B COG1 N6AMT1	3.33e-05	199	82	5	fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SLC9A8 SLC9A1 SLC8B1 PSME4 NELFCD	3.41e-05	200	82	5	0d76b006d8e8b32174e65e400acd0674354b962c
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SLC9A8 SLC9A1 SLC8B1 PSME4 NELFCD	3.41e-05	200	82	5	cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
Disease	spermatogenesis-associated protein 20 measurement	SPATA20 CACNA1G	7.26e-06	2	80	2	EFO_0802083
Disease	synucleinopathy (biomarker_via_orthology)	KIF1A KIF1B	4.34e-05	4	80	2	DOID:0050890 (biomarker_via_orthology)
Disease	autosomal recessive osteopetrosis 1 (implicated_via_orthology)	ATP6V0A1 ATP6V0A4	7.22e-05	5	80	2	DOID:0110942 (implicated_via_orthology)
Disease	nephrolithiasis (implicated_via_orthology)	SLC9A1 SLC9A3	7.22e-05	5	80	2	DOID:585 (implicated_via_orthology)
Disease	1-arachidonoyl-GPI (20:4) measurement	FADS1 TMC4	1.51e-04	7	80	2	EFO_0800256
Disease	1-linoleoyl-GPI (18:2) measurement	FADS1 TMC4	1.51e-04	7	80	2	EFO_0800266
Disease	1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) measurement	FADS1 TMC4	1.51e-04	7	80	2	EFO_0800609
Disease	level of Phosphatidylinositol (16:0_18:2) in blood serum	FADS1 TMC4	2.01e-04	8	80	2	OBA_2045153
Disease	renal tubular acidosis (implicated_via_orthology)	ATP6V0A1 ATP6V0A4	2.01e-04	8	80	2	DOID:14219 (implicated_via_orthology)
Disease	1-palmitoyl-2-oleoyl-GPI (16:0/18:1) measurement	FADS1 TMC4	2.58e-04	9	80	2	EFO_0800439
Disease	1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4) measurement	FADS1 TMC4	2.58e-04	9	80	2	EFO_0800412
Disease	1-stearoyl-2-oleoyl-GPI (18:0/18:1) measurement	FADS1 TMC4	3.22e-04	10	80	2	EFO_0800469
Disease	ocular hypertension, response to triamcinolone acetonide	LDLRAD2 DENND5A VARS1	3.23e-04	49	80	3	EFO_0006954, EFO_1001069
Disease	glycerophospholipid measurement	FADS1 SPATA20 TMC4	3.23e-04	49	80	3	EFO_0007630
Disease	level of Phosphatidylinositol (16:0_18:1) in blood serum	FADS1 TMC4	4.71e-04	12	80	2	OBA_2045152
Disease	nervous system disease (implicated_via_orthology)	KIF1A KIF1B	4.71e-04	12	80	2	DOID:863 (implicated_via_orthology)
Disease	1-stearoyl-2-linoleoyl-GPI (18:0/18:2) measurement	FADS1 TMC4	5.55e-04	13	80	2	EFO_0800413
Disease	diacylglycerol 38:4 measurement	FADS1 TMC4	6.47e-04	14	80	2	EFO_0020066
Disease	1-stearoyl-2-dihomo-linolenoyl-GPI (18:0/20:3n3 or 6) measurement	FADS1 TMC4	6.47e-04	14	80	2	EFO_0022085
Disease	phosphatidate measurement	FADS1 TMC4	7.45e-04	15	80	2	EFO_0020047
Disease	1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) measurement	FADS1 TMC4	8.50e-04	16	80	2	EFO_0800184
Disease	level of Phosphatidylinositol (18:0_18:1) in blood serum	FADS1 TMC4	1.08e-03	18	80	2	OBA_2045155
Disease	renovascular hypertension (biomarker_via_orthology)	SLC9A1 SLC9A3	1.20e-03	19	80	2	DOID:1591 (biomarker_via_orthology)
Disease	hydrocephalus (implicated_via_orthology)	TMEM67 E2F5	1.20e-03	19	80	2	DOID:10908 (implicated_via_orthology)
Disease	diacylglycerol 38:3 measurement	FADS1 TMC4	1.20e-03	19	80	2	EFO_0020065
Disease	skin aging measurement	SEMA4D FADS1 EIF2B2 PLXNA1	1.51e-03	181	80	4	EFO_0008006
Disease	Edema	SLC9A1 SLC9A3	2.26e-03	26	80	2	C0013604
Disease	Anasarca	SLC9A1 SLC9A3	2.26e-03	26	80	2	C0151603
Disease	oral squamous cell carcinoma (is_implicated_in)	FAT1 BRINP2	2.62e-03	28	80	2	DOID:0050866 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SFQLLRYPPFLPVAF	CHTF18	691	Q8WVB6
FPLLLLYPLTYLAPS	ADCK2	111	Q7Z695
LFSFPFLYHPLPLPS	nan	26	Q9N2J8
SIVIPPFGEYPALTL	ABCA4	1391	P78363
ELLTCDPPLELPSFY	ADGRA3	231	Q8IWK6
LAFLPPEATYSLVPE	ABHD17A	26	Q96GS6
FLPPLYSLVFVFGLL	CCR4	41	P51679
SIYAREVATPLFPPL	DLL3	581	Q9NYJ7
RYEILSPVPSPLFSI	CDHR4	266	A6H8M9
FPEPLIIPVLYLTSL	BAZ1A	81	Q9NRL2
VLFPLLLPLFYPTLS	PCDHGB6	16	Q9Y5F9
LLPLFYPTLSEPIRY	PCDHGB6	21	Q9Y5F9
VLFPLLLPLFYPTLC	PCDHGB7	16	Q9Y5F8
LVPVLEGPFALPSYL	DEPDC5	1416	O75140
YPPAILPLEIFITSS	FAT1	3541	Q14517
FRFFLVYSLTPAPPA	LDLRAD2	81	Q5SZI1
IAPPYTSDFVQLFLP	NELFCD	541	Q8IXH7
LLEVISPSPHFYPDF	MGAT4B	211	Q9UQ53
LQLLTLPFFPESPRY	SLC2A7	211	Q6PXP3
LPFFPESPRYSLIQK	SLC2A7	216	Q6PXP3
FVLLTDTLYSPLPPE	KIF1B	791	O60333
STSFLYYPDPVLEPL	PLXNA1	1141	Q9UIW2
PILSPSFSAQLYFRP	PIK3C2A	121	O00443
VLRSFPPDAILFYIP	PI4KA	1641	P42356
FYLTYPPLTIAEPLE	KIAA1549L	1031	Q6ZVL6
DVVLLGYPVPFSLSP	PGGHG	501	Q32M88
TFSEPLPFLYVLLPA	NPBWR2	36	P48146
VFPLLRLSPTPADDY	E2F5	311	Q15329
PTPLPFLGTILFYLR	CYP3A43	41	Q9HB55
ALFYTLPEGLLPDPA	COG1	271	Q8WTW3
LPYPALAPVVFFYLS	CACNA1G	51	O43497
LIFNSYMLPPLFLEP	MT-CO2	116	P00403
FAKDLPSFLVPSLPY	CRACD	791	Q6ZU35
VPTLPFRPALDYAFS	DMRTA1	461	Q5VZB9
FLSDQPEPYLPFLSR	DENND5B	546	Q6ZUT9
PEPYLPFLSRFIETQ	DENND5B	551	Q6ZUT9
LSDQPEPYLPFLSRF	DENND5A	561	Q6IQ26
FFLIGPPALLPLYFQ	FADS1	266	O60427
RSLEFLLPPEPDYSL	IRF9	206	Q00978
LLPPEPDYSLLLTFI	IRF9	211	Q00978
RTFLSIPSAPPLYLD	CCDC168	5551	Q8NDH2
FRPPSPDVLAYLDFS	DIP2A	1141	Q14689
PVFDYVPPELITLFI	EIF2B2	311	P49770
NLPLVVLFPPGIFYS	CENPI	576	Q92674
SLPLLILAPFLEYFS	SLC15A5	356	A6NIM6
YIGVLVFASFPSPPL	SLC38A9	406	Q8NBW4
FVLLTDTLYSPLPPD	KIF1A	751	Q12756
FYLLGIPSLPETFFL	OR2AT4	16	A6NND4
IPSLPETFFLPVFFI	OR2AT4	21	A6NND4
FPPSLLPLAVTLYVS	SLC8B1	91	Q6J4K2
PISKILIDFPTPIFY	TMEM67	381	Q5HYA8
TALLLPFRYVLDPPA	VARS1	166	P26640
FPLIAARPFTIPYLT	TAF8	211	Q7Z7C8
ARPFTIPYLTALLPS	TAF8	216	Q7Z7C8
FSDTPYLPLLAFPFV	TBC1D31	491	Q96DN5
YSFLLPVTPDFSLLP	SLC26A8	341	Q96RN1
QLLLLPFFPESPRYL	SLC2A5	206	P22732
TPTVFFFYLLPPIVL	SLC9A3	111	P48764
LPVLLSFFGPYPEVS	PTCH1	1171	Q13635
FFLLLLPPIIFESGY	SLC9A8	126	Q9Y2E8
DYLTPPVAALFLLAI	SLC5A3	446	P53794
YLAPPITALFLLAIF	SLC5A9	466	Q2M3M2
FYTPPNFVLALVLPS	STEAP2	426	Q8NFT2
AFFADLPDPLIPYSL	ARHGAP5	1336	Q13017
SPGLKVPVFYALFTP	SEMA4D	301	Q92854
FNVSSLPYAVPPLSL	ITGA2B	961	P08514
DFFSLPLPLAPEFIR	BRINP2	106	Q9C0B6
SLTFDVIPLLDPYGP	COASY	261	Q13057
DFLSSLPLHEYPPAF	PIAS3	506	Q9Y6X2
DLPAFYFDPLINPIS	PRPF8	346	Q6P2Q9
KVSITFDPFLYLPVP	USP19	661	O94966
YLSPPLPFSTAVVRL	UNC80	2666	Q8N2C7
LPTPLLTAEYLPAFA	ARHGAP40	356	Q5TG30
FYLPPTFTLTLLVPC	STEAP3	426	Q658P3
LPTSLFPVEYIPAFI	ARHGAP28	466	Q9P2N2
PKFPTPVILSFLFSY	SPATA20	266	Q8TB22
ISSVPLLYSIFLIPP	TMC4	601	Q7Z404
FVAYPEALTLLPISP	SLC6A9	441	P48067
FFLFLLPPIILDAGY	SLC9A1	161	P19634
YPPPNLAFLEVLSEF	STAG1	996	Q8WVM7
ITYFEIFLPTSLPPE	PSME4	211	Q14997
PAPYTIITFPFLFAV	ATP6V0A1	391	Q93050
INPAPYTIITFPFLF	ATP6V0A4	391	Q9HBG4
SALLLLPPFPVLSTY	TOGARAM1	6	Q9Y4F4
PLFAGYLPLPDVRLF	TRAPPC10	1151	P48553
FLPLSLSLFLPFFPS	TMEM78	71	Q5T7P6
IDAALLPTPFFPLFL	ZNF106	1146	Q9H2Y7
RAFLPPASAPYSLLD	SOX14	126	O95416
LAPPFPELRYLSLAY	XRRA1	366	Q6P2D8
FPLVPDLLSPRGLFY	N6AMT1	156	Q9Y5N5