Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	DOCK5 PCDHA10 CACNA1H SOX8 MMP19 MTHFD1 ADAM15 EPHA2 LPA PHACTR4 MEOX1	3.81e-05	1483	37	11	GO:0048646
Domain	Ion_trans_dom	TRPM6 CACNA1H SCN4A	1.48e-03	114	37	3	IPR005821
Domain	Ion_trans	TRPM6 CACNA1H SCN4A	1.48e-03	114	37	3	PF00520
Domain	Cadherin_tail	PCDHA10 PCDHA6	2.43e-03	37	37	2	PF15974
Domain	Cadherin_CBD	PCDHA10 PCDHA6	2.43e-03	37	37	2	IPR031904
Domain	CYSTEINE_SWITCH	MMP19 ADAM15	2.98e-03	41	37	2	PS00546
Domain	Pept_M10_metallopeptidase	MMP19 ADAM15	3.28e-03	43	37	2	IPR001818
Domain	Channel_four-helix_dom	CACNA1H SCN4A	5.69e-03	57	37	2	IPR027359
Domain	-	CACNA1H SCN4A	5.69e-03	57	37	2	1.20.120.350
Domain	Cadherin_2	PCDHA10 PCDHA6	7.34e-03	65	37	2	PF08266
Domain	Cadherin_N	PCDHA10 PCDHA6	7.34e-03	65	37	2	IPR013164
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	GEMIN4 ATP11C MCM7 HERC2 WDR6 EPHA2	1.10e-06	313	38	6	38270169
Pubmed	Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).	USP10 WDR6 VPS4A	5.30e-06	31	38	3	26678539
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	GEMIN4 MCM7 SOX8 WDR6 PHF12 BCORL1	5.80e-06	418	38	6	34709266
Pubmed	Prognostic significance of folate metabolism polymorphisms for lung cancer.	MTHFD1 TRDMT1	1.16e-05	5	38	2	17533396
Pubmed	A phenotype-based screen for embryonic lethal mutations in the mouse.	PHACTR4 MEOX1	3.24e-05	8	38	2	9636176
Pubmed	Two quantitative trait loci affecting progressive hearing loss in 101/H mice.	CACNA1H SOX8	3.24e-05	8	38	2	16897347
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	GEMIN4 MCM7 HERC2 MTHFD1 WDR6	5.87e-05	383	38	5	29331416
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA10 PCDHA6	6.35e-05	11	38	2	9655502
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GEMIN4 MCM7 HERC2 MTHFD1 ANLN WDR6 VPS4A WDR70	8.86e-05	1353	38	8	29467282
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA10 PCDHA6	1.21e-04	15	38	2	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA10 PCDHA6	1.56e-04	17	38	2	29911975
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	USP10 HERC2 WDR6 LPA WDR70	1.61e-04	475	38	5	31040226
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA10 PCDHA6	1.76e-04	18	38	2	10662547
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA10 PCDHA6	1.76e-04	18	38	2	15570159
Pubmed	Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.	MMP19 ADAM15	1.96e-04	19	38	2	15063736
Pubmed	Detection of genes regulated by Lmx1b during limb dorsalization.	GDF5 RFX4	2.90e-04	23	38	2	22417325
Pubmed	SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.	MCM7 MTHFD1 WDR6	3.09e-04	120	38	3	37929963
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	USP10 MCM7 ANLN WDR6 PHACTR4	3.14e-04	549	38	5	38280479
Pubmed	The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.	SOX8 MEOX1	3.16e-04	24	38	2	16582099
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA10 PCDHA6	3.16e-04	24	38	2	24698270
Pubmed	Integral and associated lysosomal membrane proteins.	ATP11C ZFYVE26 SLC2A8	3.57e-04	126	38	3	17897319
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	GEMIN4 USP10 MCM7 MTHFD1 WDR6 VPS4A TOM1	3.74e-04	1257	38	7	37317656
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA10 PCDHA6	4.32e-04	28	38	2	15347688
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	USP10 VPS4A BANP WDR70	4.35e-04	326	38	4	17015433
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	GDF5 MEOX1	4.63e-04	29	38	2	22972626
Pubmed	TopBP1 controls BLM protein level to maintain genome stability.	GEMIN4 MCM7	4.63e-04	29	38	2	24239288
Pubmed	Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.	MCM7 MTHFD1	4.96e-04	30	38	2	34017080
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	HERC2 ANLN PHF12 BCORL1 WDR70	5.00e-04	608	38	5	36089195
Pubmed	Functional analysis of secreted and transmembrane proteins critical to mouse development.	EPHA2 MEOX1	5.30e-04	31	38	2	11431694
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	ATP11C MCM7 MTHFD1 WDR6 EPHA2 PHACTR4	5.41e-04	952	38	6	38569033
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	ATP11C MCM7 HERC2 VPS4A BANP	5.71e-04	626	38	5	33644029
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TRPM6 GEMIN4 USP10 MCM7 MTHFD1 WDR6 VPS4A	7.90e-04	1425	38	7	30948266
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK5 USP10 CACNA1H PNPLA7 BANP TOM1 WDR70	1.02e-03	1489	38	7	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	GEMIN4 USP10 HERC2 MTHFD1 ANLN PHF12 TOM1	1.05e-03	1497	38	7	31527615
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	MTHFD1 WDR6	1.07e-03	44	38	2	26471122
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	ZFYVE26 HERC2	1.07e-03	44	38	2	27534441
Interaction	PHF21A interactions	GEMIN4 MCM7 SOX8 WDR6 PHF12 BANP BCORL1	2.12e-06	343	36	7	int:PHF21A
Disease	MAJOR AFFECTIVE DISORDER 2	DDC TOM1	2.06e-04	17	37	2	C1839839
Disease	1,5 anhydroglucitol measurement	PCDHA10 PCDHA6	6.08e-04	29	37	2	EFO_0008009
Disease	Parkinson's disease (biomarker_via_orthology)	GDF5 DDC	6.51e-04	30	37	2	DOID:14330 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RTPNSSSYCPSEPMM	BANP	336	Q8N9N5
MGSCLFERLPSLPPM	ADAM15	406	Q13444
MASPPECSEMPLDLS	BCORL1	611	Q5H9F3
PTASSYPAMLADMLC	DDC	81	P20711
PTSRMEPCLMSSTPR	RFX4	651	Q33E94
MDPAASSCMRSLQPP	MEOX1	1	P50221
KMDLMAFSPSLSPCP	PCDHA6	766	Q9UN73
AFSPSLSPCPIMMGK	PCDHA6	771	Q9UN73
MDPLMALSCAPAPIT	OR11H4	191	Q8NGC9
TLMNSMDPESTPPTC	GDF5	451	P43026
ALMPAAMIAPVECPS	HERC2	3416	O95714
MTDDIPESSLFSPMP	ANLN	161	Q9NQW6
PDPCSSELDAMMLGP	MMP19	286	Q99542
STCSMGSELLPMISP	PHACTR4	326	Q8IZ21
MSLSGYMPPLCDPKD	PNPLA7	1061	Q6ZV29
QSPTFMPLIMCPSQE	MCM7	196	P33993
DLMAFSPSLPPCPMV	PCDHA10	766	Q9Y5I2
MQCFTVKPVMSLPPS	DOCK5	1426	Q9H7D0
LPTPMDCPSAIYQLM	EPHA2	836	P29317
MPACLPSPDYMVTAR	LPA	1921	P08519
PMLTASPRMLLPSSS	NOS1AP	261	O75052
SLSPPLIMCTAATPM	CACNA1H	1071	O95180
LIMCTAATPMPTPKS	CACNA1H	1076	O95180
TMSTMPGLPTRPCFY	MTHFD1	906	P11586
DMILMSPPCQPFTRI	TRDMT1	71	O14717
ILTNCVFMTMSDPPP	SCN4A	141	P35499
PPSLMLLLMCFMPET	SLC2A8	191	Q9NY64
FHMDCLEPPLTAMPL	PHF12	296	Q96QT6
MLDMSEARSQPPCSP	SOX8	1	P57073
MQMVPSLPPASECAG	ATP11C	1	Q8NB49
TLSCTPEPMTMSSPL	TRPM6	1426	Q9BX84
FPMTDLDMLSPIHTP	TOM1	151	O60784
PTMFPMTDCCFSPDD	WDR70	421	Q9NW82
MHCFSIMVTPDPSTP	WDR6	811	Q9NNW5
FMGDMPPSVTPRTCN	USP10	196	Q14694
MSMAACPEAPEPSFL	SMIM45	1	A0A590UK83
IPMMFSPPESLLASC	ZFYVE26	826	Q68DK2
ASITPMTPMTPISEC	TBPL2	181	Q6SJ96
PSMMIDDLLTPCSPG	VPS4A	366	Q9UN37
DPDACPTMPLLAMLL	GEMIN4	206	P57678