Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionserine-type endopeptidase activity

RHBDF2 MMP14 C1R ADAM17 MMP10

1.71e-06190225GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

RHBDF2 MMP14 C1R ADAM17 MMP10

2.60e-06207225GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

RHBDF2 MMP14 C1R ADAM17 MMP10

2.93e-06212225GO:0017171
GeneOntologyMolecularFunctionendopeptidase activity

RHBDF2 MMP14 C1R ADAM17 MMP10

8.80e-05430225GO:0004175
GeneOntologyMolecularFunctionmetalloendopeptidase activity

MMP14 ADAM17 MMP10

3.00e-04120223GO:0004222
GeneOntologyMolecularFunctioncell adhesion molecule binding

MMP14 PTPRM DNAJB1 ACTN4 ADAM17

4.12e-04599225GO:0050839
GeneOntologyMolecularFunctionpeptidase activity

RHBDF2 MMP14 C1R ADAM17 MMP10

6.15e-04654225GO:0008233
GeneOntologyMolecularFunctionintegrin binding

MMP14 ACTN4 ADAM17

9.01e-04175223GO:0005178
GeneOntologyMolecularFunctionmetallopeptidase activity

MMP14 ADAM17 MMP10

1.32e-03200223GO:0008237
GeneOntologyMolecularFunctionmetalloexopeptidase activity

MMP14 ADAM17

2.67e-0370222GO:0008235
DomainCYSTEINE_SWITCH

MMP14 ADAM17 MMP10

1.27e-0541213PS00546
DomainPept_M10_metallopeptidase

MMP14 ADAM17 MMP10

1.47e-0543213IPR001818
DomainMetalloPept_cat_dom

MMP14 ADAM17 MMP10

9.88e-0581213IPR024079
Domain-

MMP14 ADAM17 MMP10

9.88e-05812133.40.390.10
DomainPept_M10A_Zn_BS

MMP14 MMP10

1.25e-0415212IPR021158
DomainHemopexin_CS

MMP14 MMP10

1.62e-0417212IPR018486
DomainZINC_PROTEASE

MMP14 ADAM17 MMP10

1.74e-0498213PS00142
DomainPept_M10A_stromelysin-type

MMP14 MMP10

1.82e-0418212IPR016293
DomainPG_binding_1

MMP14 MMP10

2.26e-0420212PF01471
DomainPeptidoglycan-bd-like

MMP14 MMP10

2.26e-0420212IPR002477
DomainHemopexin-like_dom

MMP14 MMP10

3.00e-0423212IPR000585
DomainHemopexin

MMP14 MMP10

3.00e-0423212PF00045
DomainHEMOPEXIN

MMP14 MMP10

3.00e-0423212PS00024
Domain-

MMP14 MMP10

3.00e-04232122.110.10.10
DomainHEMOPEXIN_2

MMP14 MMP10

3.00e-0423212PS51642
DomainHemopexin-like_repeat

MMP14 MMP10

3.00e-0423212IPR018487
DomainHX

MMP14 MMP10

3.00e-0423212SM00120
DomainPept_M10A

MMP14 MMP10

3.00e-0423212IPR021190
DomainM10A_MMP

MMP14 MMP10

3.00e-0423212IPR033739
DomainPeptidase_M10

MMP14 MMP10

3.27e-0424212PF00413
DomainZnMc

MMP14 MMP10

4.80e-0429212SM00235
DomainPeptidase_Metallo

MMP14 MMP10

4.80e-0429212IPR006026
DomainSushi

C1R SRPX

1.54e-0352212PF00084
DomainCCP

C1R SRPX

1.66e-0354212SM00032
DomainSUSHI

C1R SRPX

1.79e-0356212PS50923
DomainSushi_SCR_CCP_dom

C1R SRPX

1.85e-0357212IPR000436
PathwayREACTOME_CD163_MEDIATING_AN_ANTI_INFLAMMATORY_RESPONSE

RHBDF2 ADAM17

5.51e-059182M29839
PathwayREACTOME_COLLAGEN_DEGRADATION

MMP14 ADAM17 MMP10

6.94e-0564183M26953
PathwayWP_MATRIX_METALLOPROTEINASES

MMP14 MMP10

6.13e-0429182MM15981
PathwayWP_MATRIX_METALLOPROTEINASES

MMP14 MMP10

6.56e-0430182M39652
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

MMP14 ADAM17 MMP10

7.01e-04140183M587
PathwayREACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES

MMP14 MMP10

7.94e-0433182M26976
PathwayREACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES

MMP14 MMP10

1.05e-0338182MM14611
PathwayWP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION

MMP14 MMP10

1.54e-0346182M46450
Pubmed

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.

RHBDF2 ADAM17

3.82e-07222229045841
Pubmed

Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains.

RHBDF2 ADAM17

3.82e-07222232103528
Pubmed

Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses.

RHBDF2 ADAM17

3.82e-07222228815577
Pubmed

Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals.

RHBDF2 ADAM17

3.82e-07222238781971
Pubmed

The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner.

RHBDF2 ADAM17

3.82e-07222232825187
Pubmed

Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype.

RHBDF2 ADAM17

3.82e-07222233957124
Pubmed

Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease.

RHBDF2 ADAM17

3.82e-07222234937930
Pubmed

iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function.

RHBDF2 ADAM17

3.82e-07222224643277
Pubmed

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.

RHBDF2 ADAM17

1.15e-06322228432785
Pubmed

EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells.

RHBDF2 ADAM17

1.15e-06322237271223
Pubmed

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.

RHBDF2 ADAM17

1.15e-06322228104813
Pubmed

Placental growth factor regulates cardiac inflammation through the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-α-converting enzyme axis: crucial role for adaptive cardiac remodeling during cardiac pressure overload.

PGF ADAM17

1.15e-06322221900081
Pubmed

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.

RHBDF2 ADAM17

1.15e-06322223801765
Pubmed

iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice.

RHBDF2 ADAM17

1.15e-06322227601030
Pubmed

VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis.

MMP14 MMP10

1.15e-06322218617643
Pubmed

MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties.

MMP14 ADAM17

1.15e-06322235944080
Pubmed

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.

RHBDF2 ADAM17

1.15e-06322222246778
Pubmed

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.

RHBDF2 ADAM17

1.15e-06322222246777
Pubmed

ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).

RHBDF2 ADAM17

1.15e-06322232060096
Pubmed

Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice.

RHBDF2 ADAM17

1.15e-06322237282854
Pubmed

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.

RHBDF2 ADAM17

1.15e-06322226535007
Pubmed

Role of iRhoms 1 and 2 in Endochondral Ossification.

RHBDF2 ADAM17

1.15e-06322233227998
Pubmed

RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?

RHBDF2 ADAM17

2.29e-06422230022999
Pubmed

Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis.

MMP14 MMP10

2.29e-06422221925226
Pubmed

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.

RHBDF2 ADAM17

2.29e-06422223348744
Pubmed

TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.

MMP14 ADAM17

2.29e-06422218762577
Pubmed

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.

RHBDF2 ADAM17

2.29e-06422225918388
Pubmed

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.

RHBDF2 ADAM17

3.82e-06522229897336
Pubmed

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

RHBDF2 ADAM17

3.82e-06522229897333
Pubmed

Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation.

RHBDF2 ADAM17

3.82e-06522229069608
Pubmed

Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.

RHBDF2 ADAM17

5.72e-06622229776906
Pubmed

The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.

RHBDF2 ADAM17

1.07e-05822234613632
Pubmed

Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.

MMP14 MMP10

1.07e-05822211865039
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

MMP14 PTPRM DNAJB1 DDX27 NCAPD3 ACTN4

2.41e-0597422628675297
Pubmed

Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation.

MMP14 MMP10

3.46e-051422225636537
Pubmed

uPARAP expression during murine lung development.

MMP14 MMP10

3.99e-051522218639653
Pubmed

Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.

MMP14 MMP10

4.56e-051622220484597
Pubmed

Matrix metalloproteinases in tumor invasion.

MMP14 MMP10

4.56e-051622210949577
Pubmed

Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.

MMP14 MMP10

4.56e-051622237701782
Pubmed

Matrix metalloproteinases.

MMP14 MMP10

8.76e-052222210419448
Pubmed

Functional interactions between matrix metalloproteinases and glycosaminoglycans.

MMP14 MMP10

8.76e-052222223421805
Pubmed

Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.

MMP14 MMP10

1.05e-042422215734845
Pubmed

iRhom2 mutation leads to aberrant hair follicle differentiation in mice.

RHBDF2 ADAM17

1.64e-043022225546423
Pubmed

Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.

MMP14 PGF MMP10

2.15e-0418622320452482
Pubmed

A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).

MMP14 PGF MMP10

2.15e-0418622320673868
Pubmed

Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.

MMP14 MMP10

2.38e-043622220587546
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

NCAPD3 MLH3 MCM9

3.61e-0422222337071664
Pubmed

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.

ADAM17 TTLL3

4.41e-044922224652767
Pubmed

Substrate-trapping techniques in the identification of cellular PTP targets.

PTPRM ACTN4

4.41e-044922215588985
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

RHBDF2 PTPRM DNAJB1 NCAPD3 ADAM17

4.47e-04106122533845483
Cytoband14q24.3

PGF MLH3

9.13e-049322214q24.3
CytobandEnsembl 112 genes in cytogenetic band chr14q24

PGF MLH3

4.12e-03200222chr14q24
CytobandEnsembl 112 genes in cytogenetic band chr18p11

PTPRM DLGAP1

4.53e-03210222chr18p11
CytobandEnsembl 112 genes in cytogenetic band chrXp11

PPP1R3F SRPX

1.39e-02377222chrXp11
GeneFamilyEndogenous ligands|Matrix metallopeptidases

MMP14 MMP10

2.00e-0424162891
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

C1R SRPX

1.14e-03571621179
CoexpressionGSE20366_EX_VIVO_VS_DEC205_CONVERSION_DN

DDX27 ADAM17 TTLL3 MMP10

2.16e-05200224M4318
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MMP14 C1R CCDC106 SRPX

1.21e-06165224cca3ba9d7d30404e3e683b8cfd500c348a4974b9
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 DNAJB1 C1R SRPX

2.50e-06198224ebceb11f50b8a6ebb7629fdbd3d31fb131ace6fd
ToppCell3'-GW_trimst-2|3' / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 DNAJB1 C1R SRPX

2.50e-06198224cf9861bc14737f2dc72e50222159e0180a6d3e5c
ToppCelltumor_Lung-Fibroblasts-COL14A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

MMP14 DNAJB1 ADAM17 SRPX

2.55e-061992240d1f2b0d10c1f8ee10c448659b2a22ea0a6a6f0d
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pmch_(Lateral_hypothalamus_(LH))|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PPP1R3F DOK2 TTLL3

2.00e-05108223ba83418023d9d296b0edd4c4e1832a33bc9b3b69
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pmch_(Lateral_hypothalamus_(LH))--|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PPP1R3F DOK2 TTLL3

2.00e-05108223a93a427ab16628c86db3bb17bfecf801f56ce270
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pmch_(Lateral_hypothalamus_(LH))-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PPP1R3F DOK2 TTLL3

2.00e-05108223673da75b24218557d01ee461a13c426040da74b9
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-Treg|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNAJB1 DLGAP1 DOK2

6.11e-051572232c767c526abcc8adea6ec4eb2cc333060bb213b5
ToppCellCOVID-19_Moderate-Treg|COVID-19_Moderate / disease group, cell group and cell class

PPP1R3F DNAJB1 DLGAP1

7.34e-051672234ddb21421cbe72c06b61dd3a5eb1337e59de42e5
ToppCellCOVID-19_Moderate-Treg|World / disease group, cell group and cell class

PPP1R3F DNAJB1 DLGAP1

7.61e-0516922327ad11239559b025bef582f89b2a83501d9d3993
ToppCellInt-URO-Lymphocyte-T_NK-dnT|Int-URO / Disease, Lineage and Cell Type

PPP1R3F DNAJB1 MLH3

8.01e-05172223e70299573da1679d6d286c3a43699cbff76e207d
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM PGF DLGAP1

8.58e-0517622388ca2f83d8301633232735f39b0683efe49d0b86
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM PGF DLGAP1

8.58e-051762237292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP14 CCDC106 DOK2

8.72e-0517722343883b65b1e03043a24fc40c84c50bac81960c12
ToppCelldroplet-Lung-LUNG-30m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP14 CCDC106 DOK2

8.72e-051772239de6a82b7fb72d20361947f7ac95bb1fa73fc2ff
ToppCelldroplet-Lung-30m-Hematologic-myeloid-interstitial_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MMP14 CCDC106 DOK2

8.87e-05178223c85de851b39cb8ef7ea1866ab64c6a387788273a
ToppCelldroplet-Lung-30m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_33|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MMP14 CCDC106 DOK2

9.02e-0517922313d80ae2e43a5daad0aeb5f47338efca2c58800a
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAJB1 PGF BNIP5

9.17e-051802238bf6e8b6b45ce42f8c5f23e7cd1752ec8b3fa2d2
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGF BNIP5 CCDC106

9.17e-051802230677bf4a5177d9cbc6716195bd966eeae8de2f31
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

PTPRM PGF SRPX

1.01e-041862232e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

PTPRM PGF SRPX

1.01e-04186223c3449e54454009973818fc1101933c6f0168258c
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.01e-041862237582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCell3'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1R PGF SRPX

1.03e-04187223f0c4d93f75615e570e4465fd622e3124189618a1
ToppCell3'-Adult-LargeIntestine-Mesenchymal-stromal_related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1R PGF SRPX

1.03e-041872233ff57da09ed8394913fb683669d7bff84a936623
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPP1R3F C1R SRPX

1.06e-04189223f7d57723b8fb0f1e1485f51e3eff93ec0f39761e
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MMP14 C1R DLGAP1

1.06e-04189223e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCellmoderate-Lymphoid-NK|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MMP14 C1R SRPX

1.06e-0418922322a19365782003c18ec8dddcdbfdaa82c4e330f6
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MMP14 C1R PGF

1.06e-04189223d531399749409d614adca13d181830c6e3287508
ToppCellCOVID-19-lung-Artery_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PTPRM DNAJB1 SRPX

1.08e-0419022307b675befcd1d0a9c90cb17b5d22323468325d51
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP14 PGF SRPX

1.09e-041912231efb47743b6834b64cb0f61721ddbe875b1a66ca
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.09e-041912234e4488380379ed29d7898bae4e24221e7c67eb9d
ToppCellLPS_only-Stromal_mesenchymal|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MMP14 C1R DLGAP1

1.11e-04192223162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C1R PGF DDX27

1.11e-041922230b954a4e5857dac45d97c491af9b27cb2d1bd339
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP14 PGF SRPX

1.11e-041922235e6f8206ee0b10cdba79a7c4a05452cb025a5512
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MMP14 C1R DLGAP1

1.11e-04192223ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1R PGF SRPX

1.11e-0419222311867f30f0b420c18cb0b34d3990237aa737a0e8
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_proliferating_myeloid_(8)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RHBDF2 BNIP5 DOK2

1.11e-04192223b204ef6e05170855259b902829a1700094eb9159
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP14 PGF SRPX

1.11e-04192223136af0186c70c14c5f2b33ed7a148156de5b478c
ToppCellfacs-Heart-RV-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP14 PGF SRPX

1.13e-0419322376f0f8569255d6cdf1e3b8e954cae72e71f87157
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

C1R PGF SRPX

1.13e-04193223261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.

DNAJB1 PGF DOK2

1.13e-041932236e9912f5444c591e698b9a7ffa3e9fc3d8ee57b0
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1R PGF SRPX

1.13e-04193223c5bd0ed6f57459e54d2463318e8d9b1879718e63
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MMP14 PGF SRPX

1.14e-041942235594f7437448cb4b37d2d100f44d30c4a367df26
ToppCellCTRL-Myeloid-Alveolar_Macrophage|CTRL / Disease state, Lineage and Cell class

PTPRM ADAM17 DOK2

1.14e-04194223be69b20afa915978c4cf2feb0bb21ab7c1f301a5
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.16e-04195223fc43cd295f2cc3f6e9442232e028944f011c82cc
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RHBDF2 DNAJB1 ADAM17

1.16e-04195223fa8ac154e5aebc26463ff84f0ad1038095770bc6
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MMP14 C1R SRPX

1.18e-04196223525d6c8a277364e624e7cc586275f8a891436b57
ToppCell368C|World / Donor, Lineage, Cell class and subclass (all cells)

DNAJB1 C1R SRPX

1.20e-04197223f41211923938e5d7bfe6bf24f604ab386f17ef10
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

C1R PGF SRPX

1.20e-0419722363b63c6b2f842adb87bc83222ff86796bd9b58f6
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1R PGF SRPX

1.20e-041972235fbbc570a4e77c703f569a4f85ce2d8af67d6297
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.20e-04197223ab5d3ebc73bd7cfc64381d14b92878b370205186
ToppCell5'-Adult-Appendix-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.20e-04197223b11a5d909942a4299cbc0b27332b1a3f66f3bccd
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

C1R PGF SRPX

1.20e-04197223fb50903b87498b400c8e16e6a561b6d9458e5d97
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C1R PGF SRPX

1.22e-04198223c66097ae9ba0b50561083c423565665958ef0bb8
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 DNAJB1 SRPX

1.22e-04198223bba40ece261741fa8c0e28de768af001d28f04f8
ToppCelltumor_Lung-Fibroblasts-COL14A1+_matrix_FBs|tumor_Lung / Location, Cell class and cell subclass

MMP14 C1R SRPX

1.22e-0419822374f2c7ef702b25a5b99e56121229e678ed992524
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRM PGF ACTN4

1.22e-0419822372e8b9cccb7b0a2ea9d415218fff4fa2f09728f4
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteoblast_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MMP14 PGF SRPX

1.22e-04198223bc9c9f2c87282b5ef8514773e065d2a6b5dde338
ToppCellsevere-Treg|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PPP1R3F DNAJB1 DOK2

1.22e-04198223377980b9f7d02818e1d145e6884604f8bfacc4f2
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRM PGF ACTN4

1.22e-04198223e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R PGF

1.22e-04198223229588189825b1080181db9515185677b742c668
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteoblast_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

C1R PGF SRPX

1.22e-041982239d61483b0decac2fe90045b3474843360b2c49b3
ToppCellstromal_cell|World / Lineage and Cell class

C1R PGF SRPX

1.23e-04199223507a82d0529b5b1fa5aebcfe43db53f0b6e3f8f0
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.23e-0419922308bdcabc3fce787578a8eb66fc8412b0974fa6cc
ToppCellstromal_cell-stromal_cell|World / Lineage and Cell class

C1R PGF SRPX

1.23e-0419922374262363a34da3a1eb55ab375fd61ddd7bb39b23
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.23e-0419922301ab0363558f215f9979e20fd5170d8fee149cea
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRM PGF ACTN4

1.23e-041992239c40b3ee39860e9d8edafd007daec11abdd95435
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MMP14 C1R SRPX

1.23e-0419922395d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

C1R PGF SRPX

1.23e-041992230cdbedf09ec72734b86ddab3fec562e066afed92
ToppCellILEUM-inflamed-(8)_Fibroblast|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MMP14 C1R SRPX

1.23e-04199223cb3c04b91c8e8080137823b11c76ca0a2adda52d
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 DNAJB1 SRPX

1.23e-041992231f5ad0f1971156b28a8d46a380bda906b5fdbedc
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRM PGF ACTN4

1.23e-0419922372b34bce8157abe389e95cd3ed8ba578dce0cbf6
ToppCellILEUM-inflamed-(8)_Activated_fibroblasts|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MMP14 C1R SRPX

1.23e-04199223317f412996d463ddf2e6a52ff41d5d676c77f43f
ToppCell3'-Adult-LargeIntestine-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.25e-0420022387177c973e722ac7d9ee503b9cfacd84fc67865d
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MMP14 C1R SRPX

1.25e-04200223747c61d4e0b746278ae1f45ca4cd556c6961c76a
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.25e-04200223933b5b400e48a511ba0a056be1d33d3610b5f10d
ToppCell390C-Fibroblasts-Fibroblast-H-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MMP14 C1R SRPX

1.25e-04200223b6f21f5cc137eddf6ba90e81cae791b57d88d9d7
ToppCell390C-Fibroblasts-Fibroblast-H-|390C / Donor, Lineage, Cell class and subclass (all cells)

MMP14 C1R SRPX

1.25e-04200223ec7d6a08e34bcad5b3bbff56ebef96ae17e4cefd
ToppCell5'-Adult-Distal_Rectal-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.25e-04200223db6281b5d4032116310db379d9175d790994c99c
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.25e-04200223cbf6a6c3db88bac37bd084a3a914b12b3af524eb
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.25e-04200223cfea2f9d85646c9b722150551ff2e8fc4f6cc98a
ToppCellCOVID-19|World / group, cell type (main and fine annotations)

MMP14 DNAJB1 C1R

1.25e-04200223ac38a468559c33ee00152735ce6e408f3f48df84
ToppCell390C-Fibroblasts-Fibroblast-H|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MMP14 C1R SRPX

1.25e-04200223019340e8b4b4944a49e14fdec7ce2954cbb8ba2e
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MMP14 C1R SRPX

1.25e-042002230e1f9e1622e5a0fd814a1e100f79cbca2e0dbfbb
ToppCell15-Airway|15 / Age, Tissue, Lineage and Cell class

MMP14 C1R SRPX

1.25e-04200223ba4b8d5becf81351901c2ecac74ffa28e29586f3
ToppCellnormal_Lung-Fibroblasts-COL14A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

DNAJB1 C1R SRPX

1.25e-042002236d8f6a6b3f61c529fbed1376659641030abf4f2c
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MMP14 C1R PGF

1.25e-04200223ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCellwk_20-22-Mesenchymal-Fibroblast-intermediate_fibro|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MMP14 C1R SRPX

1.25e-04200223d769723f8fcb37d9b86589e0c41c1d7f16393cfe
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.25e-04200223a2bb67a06757f19be3f56f8cb5bb7e2affa5f4ed
ToppCellFibroblast|World / shred by cell class for parenchyma

MMP14 C1R SRPX

1.25e-04200223dec9ce1bc2571197003596f32e5f742ede72aa79
ToppCell(5)_Fibroblast-H|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

MMP14 C1R SRPX

1.25e-0420022394e77a1082ade6fad93a37168e037af8aefe7ff4
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.25e-04200223f6cf98aad53aa8b3fa02cf874d6f7cd75530a213
ToppCell15-Airway-Mesenchymal|Airway / Age, Tissue, Lineage and Cell class

MMP14 C1R SRPX

1.25e-0420022313c4835b98e1bb91c2d04e08cdeaed8eba30b1d9
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuroepithelial-Proteoglycan-expressing_cell|3m / Sample Type, Dataset, Time_group, and Cell type.

MMP14 C1R SRPX

1.25e-0420022394ef227b2162ba77af33b8cc8aaa4a7e3bdf79a7
ToppCell390C-Fibroblasts-Fibroblast-H|390C / Donor, Lineage, Cell class and subclass (all cells)

MMP14 C1R SRPX

1.25e-04200223671e731977c58a0c44c36b56422085d93d999aad
ToppCellILEUM-inflamed-(8)_Fibroblast-(8)_Activated_fibroblasts|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MMP14 DNAJB1 SRPX

1.25e-042002232518d1758e2730b028270e76b949cebbeb7fb5ce
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuroepithelial|3m / Sample Type, Dataset, Time_group, and Cell type.

MMP14 C1R SRPX

1.25e-04200223429028c3112d279b26abf3296e01b1884b4b7fcb
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-dn_T|Int-URO / Disease, condition lineage and cell class

PPP1R3F DNAJB1 MLH3

1.25e-04200223020439d9e70fff7246650ab0e9105236688c3ec3
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMP14 C1R SRPX

1.25e-0420022310f0c20ba7c71d9e2e177597f85b41cb40f0d878
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MMP14 C1R SRPX

1.25e-04200223de1d193f773f4e2927baa6fc38d29754b015c6e6
ComputationalGenes in the cancer module 107.

MMP14 C1R MMP10

1.31e-0479143MODULE_107
ComputationalMMPs.

MMP14 MMP10

3.26e-0421142MODULE_562
ComputationalGenes in the cancer module 371.

MMP14 MMP10

5.03e-0426142MODULE_371
ComputationalGenes in the cancer module 210.

MMP14 MMP10

5.84e-0428142MODULE_210
ComputationalMetal / Ca ion binding.

MMP14 C1R MMP10

6.10e-04133143MODULE_324
ComputationalMetal ion (zinc) binding.

MMP14 MMP10

1.51e-0345142MODULE_280
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

C1R MMP10

1.86e-0350142GAVISH_3CA_METAPROGRAM_EPITHELIAL_EMT_LIKE_1
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

DNAJB1 DOK2

1.86e-0350142GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_STRESS_HSP
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

DNAJB1 DOK2

1.86e-0350142GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_HEAT_SHOCK
DrugMG-262; Up 200; 0.1uM; PC3; HT_HG-U133A

MMP14 DNAJB1 PGF MMP10

1.31e-051612147068_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

RHBDF2 CCDC106 MLH3 MCM9

2.73e-051942142523_DN
DrugCefamandole sodium salt [30034-03-8]; Down 200; 8.2uM; PC3; HT_HG-U133A

MMP14 ADAM17 MLH3 MCM9

2.79e-051952147394_DN
Drugradicicol; Up 200; 0.1uM; SKMEL5; HG-U133A

MMP14 DNAJB1 PGF ADAM17

2.84e-05196214493_UP
Drugmarimastat

MMP14 ADAM17 MMP10

3.26e-0568213CID000119031
DrugOrganoselenium Compounds

DNAJB1 PGF MMP10

3.71e-0571213ctd:D016566
DrugAC1L1GXT

MMP14 PGF MMP10

4.20e-0574213CID000003890
DiseaseEsophageal Neoplasms

MMP14 MLH3

1.54e-0378222C0014859
DiseaseMalignant neoplasm of esophagus

MMP14 MLH3

1.54e-0378222C0546837
Diseasemyocardial infarction (is_implicated_in)

MMP14 PGF

2.46e-0399222DOID:5844 (is_implicated_in)
Diseasecongestive heart failure (biomarker_via_orthology)

MMP14 ADAM17

2.87e-03107222DOID:6000 (biomarker_via_orthology)
Diseasepancreatic carcinoma

NCAPD3 DOK2

7.39e-03174222EFO_0002618

Protein segments in the cluster

PeptideGeneStartEntry
ISGERLPKPERGKMR

ACTN4

91

O43707
RGKDDEIPCRRMRSG

DLGAP1

331

O14490
RAMPRCKIKDCGQPR

C1R

366

P00736
KDVIRPGMRRKVPGE

DNAJB1

286

P25685
AKRARAMPEEEPVRG

DDX27

721

Q96GQ7
KAMRRPRCGVPDKFG

MMP14

86

P50281
DTLEVMRKPRCGVPD

MMP10

81

P09238
GPEKPRRCEAARKVI

DOK2

46

O60496
PVRRKCMDPRLEFEK

MLH3

156

Q9UHC1
TPERPAKKIREEEMC

POM121B

31

A6NF01
MENPRCPRRPLAEKK

BNIP5

1

P0C671
RMEAEDHCRMKPGPR

CCDC106

101

Q9BWC9
DHCRMKPGPRRMEGD

CCDC106

106

Q9BWC9
KRRPEEEMALGICAK

FRMPD2

556

Q68DX3
RTRTKCADPMRGPRK

PTPRM

371

P28827
CADPMRGPRKLEVVE

PTPRM

376

P28827
HGPREKVMCAPEKRI

MCM9

1001

Q9NXL9
DMEPPRIKCPSVKER

SRPX

176

P78539
RVKRRADPDPMKNTC

ADAM17

211

P78536
HRKRGKPPRREDIEM

NCAPD3

176

P42695
REKMKPERCGDAVPR

PGF

206

P49763
KSCMKPVRRRPAEEE

PPP1R3F

326

Q6ZSY5
RPDCDKPRAEACPMK

TTLL3

681

Q9Y4R7
CKMPKIVDPLARGRA

RHBDF2

181

Q6PJF5